anorexia nervosa

Summary

Summary: An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)

Top Publications

  1. ncbi Neuropsychological investigation of decision-making in anorexia nervosa
    Paolo Cavedini
    Department of Neuropsychiatric Sciences, San Raffaele Scientific Institute, Vita Salute San Raffaele University, 20, via Stamira D Ancona, 20127 Milan, Italy
    Psychiatry Res 127:259-66. 2004
  2. pmc The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication
    James I Hudson
    Department of Psychiatry, Harvard Medical School and Biological Psychiatry Laboratory, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 61:348-58. 2007
  3. ncbi The socio-emotional processing stream in Anorexia Nervosa
    A Oldershaw
    King s College London, Institute of Psychiatry, Division of Psychological Medicine and Psychiatry, Section of Eating Disorders P059, De Crespigny Park, London SE5 8AF, UK
    Neurosci Biobehav Rev 35:970-88. 2011
  4. ncbi Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlation with body mass index
    Andreas Stengel
    Charité Center for Internal Medicine and Dermatology, Division of General Internal and Psychosomatic Medicine, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Peptides 39:125-30. 2013
  5. ncbi Mortality rates in patients with anorexia nervosa and other eating disorders. A meta-analysis of 36 studies
    Jon Arcelus
    Loughborough University Centre for Research into Eating Disorders, Loughborough University England
    Arch Gen Psychiatry 68:724-31. 2011
  6. ncbi Eating disorders
    Janet Treasure
    Section of Eating Disorders, Institute of Psychiatry, King s College London, London, UK
    Lancet 375:583-93. 2010
  7. ncbi New insights into symptoms and neurocircuit function of anorexia nervosa
    Walter H Kaye
    Eating Disorder Treatment and Research Program, Department of Psychiatry, University of California, San Diego, La Jolla Village Professional Center, 8950 Villa La Jolla Drive, Suite C 207, La Jolla, California 92037, USA
    Nat Rev Neurosci 10:573-84. 2009
  8. ncbi Review of the prevalence and incidence of eating disorders
    Hans Wijbrand Hoek
    Parnassia Psychiatric Institute, The Hague, The Netherlands
    Int J Eat Disord 34:383-96. 2003
  9. ncbi Disruption of visuospatial and somatosensory functional connectivity in anorexia nervosa
    Angela Favaro
    Psychiatric Clinic, Department of Neurosciences, University of Padova, Padova, Italy
    Biol Psychiatry 72:864-70. 2012
  10. ncbi Hunger and satiety in anorexia nervosa: fMRI during cognitive processing of food pictures
    Stephanie Santel
    Department of Child and Adolescent Psychiatry, University Magdeburg, Germany
    Brain Res 1114:138-48. 2006

Detail Information

Publications353 found, 100 shown here

  1. ncbi Neuropsychological investigation of decision-making in anorexia nervosa
    Paolo Cavedini
    Department of Neuropsychiatric Sciences, San Raffaele Scientific Institute, Vita Salute San Raffaele University, 20, via Stamira D Ancona, 20127 Milan, Italy
    Psychiatry Res 127:259-66. 2004
    b>Anorexia nervosa (AN) could be considered a form of obsessive-compulsive disorder in which an impairment of the cognitive domain related to decision-making was found...
  2. pmc The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication
    James I Hudson
    Department of Psychiatry, Harvard Medical School and Biological Psychiatry Laboratory, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 61:348-58. 2007
    ..Little population-based data exist on the prevalence or correlates of eating disorders...
  3. ncbi The socio-emotional processing stream in Anorexia Nervosa
    A Oldershaw
    King s College London, Institute of Psychiatry, Division of Psychological Medicine and Psychiatry, Section of Eating Disorders P059, De Crespigny Park, London SE5 8AF, UK
    Neurosci Biobehav Rev 35:970-88. 2011
    The significance of socio-emotional factors in development and maintenance of Anorexia Nervosa (AN) has been noted, but the literature is poorly integrated without clear models guiding research or treatment...
  4. ncbi Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlation with body mass index
    Andreas Stengel
    Charité Center for Internal Medicine and Dermatology, Division of General Internal and Psychosomatic Medicine, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Peptides 39:125-30. 2013
    ..However, the regulation of irisin under conditions of severely altered body weight such as anorexia nervosa and obesity remains to be investigated...
  5. ncbi Mortality rates in patients with anorexia nervosa and other eating disorders. A meta-analysis of 36 studies
    Jon Arcelus
    Loughborough University Centre for Research into Eating Disorders, Loughborough University England
    Arch Gen Psychiatry 68:724-31. 2011
    ..Morbidity and mortality rates in patients with eating disorders are thought to be high, but exact rates remain to be clarified...
  6. ncbi Eating disorders
    Janet Treasure
    Section of Eating Disorders, Institute of Psychiatry, King s College London, London, UK
    Lancet 375:583-93. 2010
    ..The diagnostic criteria are in the process of review, and the probable four new categories are: anorexia nervosa, bulimia nervosa, binge eating disorder, and eating disorder not otherwise specified...
  7. ncbi New insights into symptoms and neurocircuit function of anorexia nervosa
    Walter H Kaye
    Eating Disorder Treatment and Research Program, Department of Psychiatry, University of California, San Diego, La Jolla Village Professional Center, 8950 Villa La Jolla Drive, Suite C 207, La Jolla, California 92037, USA
    Nat Rev Neurosci 10:573-84. 2009
    Individuals with anorexia nervosa have a relentless preoccupation with dieting and weight loss that results in severe emaciation and sometimes death...
  8. ncbi Review of the prevalence and incidence of eating disorders
    Hans Wijbrand Hoek
    Parnassia Psychiatric Institute, The Hague, The Netherlands
    Int J Eat Disord 34:383-96. 2003
    ..To review the literature on the incidence and prevalence of eating disorders...
  9. ncbi Disruption of visuospatial and somatosensory functional connectivity in anorexia nervosa
    Angela Favaro
    Psychiatric Clinic, Department of Neurosciences, University of Padova, Padova, Italy
    Biol Psychiatry 72:864-70. 2012
    Although body image disturbance is considered one of the core characteristics of anorexia nervosa (AN), the exact nature of this complex feature is poorly understood...
  10. ncbi Hunger and satiety in anorexia nervosa: fMRI during cognitive processing of food pictures
    Stephanie Santel
    Department of Child and Adolescent Psychiatry, University Magdeburg, Germany
    Brain Res 1114:138-48. 2006
    Neuroimaging studies of visually presented food stimuli in patients with anorexia nervosa have demonstrated decreased activations in inferior parietal and visual occipital areas, and increased frontal activations relative to healthy ..
  11. ncbi Risk of major adverse perinatal outcomes in women with eating disorders
    Nadia Micali
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, Box 085, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 190:255-9. 2007
    ..Low birth weight, prematurity and higher miscarriage rates have previously been reported in women with eating disorders...
  12. ncbi Reduced perception of bodily signals in anorexia nervosa
    Olga Pollatos
    Department of Psychology, Ludwig Maximilians University of Munich, Germany
    Eat Behav 9:381-8. 2008
    ..The objective of the study was to elucidate this potential relationship and to clarify whether general interoceptive sensitivity is reduced in anorexia nervosa.
  13. ncbi Neuroimaging in eating disorders and obesity: implications for research
    Frederique van den Eynde
    Institute of Psychiatry, Section of Eating Disorders PO59, De Crespigny Park, SE5 8AF, London, UK
    Child Adolesc Psychiatr Clin N Am 18:95-115. 2009
    ..These imaging techniques allow researchers to study not only the configuration of brain structures but also aspects of normal and anomalous human behavior more accurately...
  14. ncbi Emotional theory of mind and emotional awareness in recovered anorexia nervosa patients
    Anna Oldershaw
    King s College London, Institute of Psychiatry, Division of Psychological Medicine and Psychiatry, Section of Eating Disorders, London, SE5 8AF, UK
    Psychosom Med 72:73-9. 2010
    ..theory of mind (eToM) are limited to the ill state or if this condition is a stable deficit that persists with recovery in adults with anorexia nervosa (AN). This is in keeping with observations of similarities between the disorders.
  15. ncbi Medial prefrontal cortex activity associated with symptom provocation in eating disorders
    Rudolf Uher
    Institute of Psychiatry PO59, Eating Disorders Unit, King s College London, De Crespigny Park, London SE5 8AF, UK
    Am J Psychiatry 161:1238-46. 2004
    ..The authors sought to identify neural correlates of eating disorders in order to contribute to the debate on the genesis and classification of eating disorders and provide endophenotypes for genetic research...
  16. ncbi Anorexia nervosa: valued and visible. A cognitive-interpersonal maintenance model and its implications for research and practice
    Ulrike Schmidt
    Section of Eating Disorders, Institute of Psychiatry, De Crespigny Park, PO Box 59, London SE5 8AF, UK
    Br J Clin Psychol 45:343-66. 2006
    b>Anorexia nervosa (AN) is highly valued by people with the disorder. It is also a highly visible disorder, evoking intense emotional responses from others, particularly those closest to the person...
  17. ncbi Anticipation of body-scaled action is modified in anorexia nervosa
    Dewi Guardia
    Laboratoire de Neurosciences Fonctionnelles et Pathologies CNRS FRE 3291, Lille, France
    Neuropsychologia 48:3961-6. 2010
    Patients with anorexia nervosa frequently believe they are larger than they really are...
  18. pmc Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study
    Samantha J Brooks
    Section of Eating Disorders, Institute of Psychiatry, King s College London, London, SE5 8AF UK
    BMC Psychiatry 11:179. 2011
    Previous Magnetic Resonance Imaging (MRI) studies of people with anorexia nervosa (AN) have shown differences in brain structure...
  19. ncbi Structural magnetic resonance imaging in eating disorders: a systematic review of voxel-based morphometry studies
    Frederique van den Eynde
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, Section of Eating Disorders, London, UK
    Eur Eat Disord Rev 20:94-105. 2012
    ..Nevertheless, these preliminary data suggest that, compared with healthy controls, people with anorexia nervosa have decreased grey matter in a range of brain regions and that those with bulimia nervosa have increased ..
  20. ncbi Treatment of anorexia nervosa: insights and obstacles
    Angela S Guarda
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Physiol Behav 94:113-20. 2008
    b>Anorexia nervosa is a behavioral disorder characterized by ego-syntonic self-starvation, denial of illness and ambivalence towards treatment. Treatment refusal and drop-out rates are high and relapse is common...
  21. ncbi Reluctance to recover in anorexia nervosa
    Ragnfrid H S Nordbø
    Norwegian Institute of Public Health, Division of Mental Health, Oslo, Norway
    Eur Eat Disord Rev 20:60-7. 2012
    Reluctance to recover may explain poor treatment outcome and high dropout and relapse rates in the treatment of anorexia nervosa (AN). This study systematically explored what AN patients describe as interfering with their wish to recover.
  22. pmc Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E1898-908. 2012
    Animal data suggest that oxytocin is a satiety hormone. We have demonstrated that anorexia nervosa (anorexia), a disorder characterized by food restriction, low weight, and hypoleptinemia, is associated with decreased nocturnal oxytocin ..
  23. ncbi Motivational change in an inpatient anorexia nervosa population and implications for treatment
    Tracey D Wade
    School of Psychology, Flinders University, Adelaide, SA, Australia
    Aust N Z J Psychiatry 43:235-43. 2009
    The relationship between motivation and recovery in anorexia nervosa has received increased attention in the research literature although few controlled investigations of increasing motivation in this population exist...
  24. ncbi Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia
    J Hebebrand
    Department of Child and Adolescent Psychiatry, Philipps University Marburg, Hans Sachs Strasse 6, 35033 Marburg, Germany
    Physiol Behav 79:25-37. 2003
    Patients with anorexia nervosa (AN) often show normal to elevated physical activity levels despite severe weight loss and emaciation...
  25. ncbi Comorbidity of anxiety disorders with anorexia and bulimia nervosa
    Walter H Kaye
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara St, Suite 600, Iroquois Bldg, Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:2215-21. 2004
    A large and well-characterized sample of individuals with anorexia nervosa and bulimia nervosa from the Price Foundation collaborative genetics study was used to determine the frequency of anxiety disorders and to understand how anxiety ..
  26. ncbi A systematic review and meta-analysis of set-shifting ability in eating disorders
    Marion E Roberts
    Division of Psychological Medicine, Eating Disorders Research Unit, Department of Academic Psychiatry, King s College, Guy s Hospital, London, UK
    Psychol Med 37:1075-84. 2007
    ..PsycINFO, Medline, and Web of Science databases were searched to December 2005. Hand searching of eating-disorder journals and relevant reference sections was also undertaken...
  27. ncbi The outcome of anorexia nervosa in the 20th century
    Hans Christoph Steinhausen
    Department of Child and Adolescent Psychiatry, University of Zurich, Postfach, Switzerland
    Am J Psychiatry 159:1284-93. 2002
    The present review addresses the outcome of anorexia nervosa and whether it changed over the second half of the 20th century.
  28. ncbi Eating disorders
    Christopher G Fairburn
    Oxford University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Lancet 361:407-16. 2003
    ..They are much less frequent in men. Eating disorders are divided into three diagnostic categories: anorexia nervosa, bulimia nervosa, and the atypical eating disorders...
  29. ncbi The Anorexia Nervosa Stages of Change Questionnaire (ANSOCQ): information regarding its psychometric properties
    Elizabeth Rieger
    Department of Psychology, University of Sydney, NSW 2006, Australia
    Int J Eat Disord 32:24-38. 2002
    The Anorexia Nervosa Stages of Change Questionnaire (ANSOCQ) was developed to assess patients' readiness to recover from anorexia nervosa. In this article we present additional findings supporting the psychometric properties of the ANSOCQ.
  30. ncbi Evoked facial emotional expression and emotional experience in people with anorexia nervosa
    Helen Davies
    Section of Eating Disorders, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, United Kingdom
    Int J Eat Disord 44:531-9. 2011
    To use an experimental paradigm to assess facial expression, subjective experience of emotion and the relationship between them in people with anorexia nervosa (AN).
  31. ncbi Twelve-year course and outcome predictors of anorexia nervosa
    Manfred M Fichter
    Department of Psychiatry, University of Munich, Munich, Germany
    Int J Eat Disord 39:87-100. 2006
    The current study presents the long-term course of anorexia nervosa (AN) over 12 years in a large sample of 103 patients diagnosed according to criteria in the 4th ed. of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).
  32. ncbi Brains of anorexia nervosa patients process self-images differently from non-self-images: an fMRI study
    Perminder Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Neuropsychologia 46:2161-8. 2008
    The central disturbance in anorexia nervosa (AN) is a distorted body image. This perceptual error does not extend to judging others' body shapes...
  33. ncbi Cognitive flexibility in anorexia nervosa and bulimia nervosa
    Kate Tchanturia
    Division of Psychological Medicine, Eating Disorders Research Unit, Institute of Psychiatry, King s College, De Crespigny Park, London, UK
    J Int Neuropsychol Soc 10:513-20. 2004
    The aim of this study was to determine if there are differences in cognitive flexibility in anorexia nervosa and bulimia nervosa...
  34. pmc Diagnostic crossover in anorexia nervosa and bulimia nervosa: implications for DSM-V
    Kamryn T Eddy
    Department of Psychiatry, Massachusetts General Hospital, 2 Longfellow Place, Suite 200, Boston, MA 02214, USA
    Am J Psychiatry 165:245-50. 2008
    ..Yet high rates of diagnostic "crossover" among the anorexia nervosa subtypes and bulimia nervosa may reflect problems with the validity of the current diagnostic schema, thereby ..
  35. pmc Neural basis of impaired cognitive flexibility in patients with anorexia nervosa
    Yasuhiro Sato
    Department of Psychosomatic Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan
    PLoS ONE 8:e61108. 2013
    Impaired cognitive flexibility in anorexia nervosa (AN) causes clinical problems and makes the disease hard to treat, but its neural basis has yet to be fully elucidated...
  36. ncbi Predictors of treatment acceptance and completion in anorexia nervosa: implications for future study designs
    Katherine A Halmi
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    Arch Gen Psychiatry 62:776-81. 2005
    There have been very few randomized controlled treatment studies of anorexia nervosa.
  37. ncbi [Prevalence of symptoms of anorexia nervosa and dissatisfaction with body image among female adolescents in Florianópolis, Santa Catarina State, Brazil]
    Emilaura Alves
    Programa de Pós Graduaçço em Nutriçço, Universidade Federal de Santa Catarina, Florianopolis, Brasil
    Cad Saude Publica 24:503-12. 2008
    The objective of this study was to identify the prevalence of symptoms of anorexia nervosa (EAT+) and dissatisfaction with body image among female adolescents in Florianópolis, Santa Catarina State, Brazil...
  38. ncbi A neural signature of anorexia nervosa in the ventral striatal reward system
    Anne Katharina Fladung
    University of Ulm, Department of Psychiatry, Leimgrubenweg 12 14, 89075 Ulm, Germany
    Am J Psychiatry 167:206-12. 2010
    ..and diet suggest a pivotal role for the mesolimbic reward system in the maintenance of core symptoms in anorexia nervosa, which is corroborated by initial empirical evidence in human studies...
  39. ncbi The role of the right parietal lobe in anorexia nervosa
    D Nico
    Dipartimento di Psicologia, Universita La Sapienza, Rome, Italy
    Psychol Med 40:1531-9. 2010
    Patients with anorexia nervosa (AN) overestimate their size despite being severely underweight. Whether this misperception echoes an underlying emotional disturbance or also reflects a genuine body-representation deficit is debatable...
  40. ncbi The effect of therapeutically induced weight gain on plasma leptin levels in patients with anorexia nervosa
    K Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, Aachen University, Neuenhofer Weg 21, D 52074, Aachen, Germany
    J Psychiatr Res 37:165-9. 2003
    ..it was shown that hyperleptinemia ensues from the therapeutically induced weight gain in patients with anorexia nervosa (AN). However, not all studies have been able to confirm this finding...
  41. ncbi Altered social hedonic processing in eating disorders
    Kate Tchanturia
    Section of Eating Disorders, King s College London, Institute of Psychiatry, Psychological Medicine, London, United Kingdom
    Int J Eat Disord 45:962-9. 2012
    ..Social anhedonia relates to a reduced feeling of pleasure from social stimulation. Researching the exact nature of problems in interpersonal relationships is an important topic for clinicians and researchers in the field...
  42. ncbi A prospective study of predictors of relapse in anorexia nervosa: implications for relapse prevention
    Jacqueline C Carter
    Eating Disorders Program, Toronto General Hospital, University Health Network, 200 Elizabeth Street, 8 Eaton North, Toronto, Ontario, Canada M5G 2C4
    Psychiatry Res 200:518-23. 2012
    b>Anorexia nervosa (AN) is a serious psychiatric disorder with a high rate of relapse. The goal of this study was to identify predictors of relapse in adult AN using a prospective, longitudinal design...
  43. pmc Cognitive flexibility in verbal and nonverbal domains and decision making in anorexia nervosa patients: a pilot study
    Giovanni Abbate-Daga
    Eating Disorders Center, Department of Neuroscience, University of Turin, Italy
    BMC Psychiatry 11:162. 2011
    This paper aimed to investigate cognitive rigidity and decision making impairments in patients diagnosed with Anorexia Nervosa Restrictive type (AN-R), assessing also verbal components.
  44. ncbi Neuropsychological weaknesses in anorexia nervosa: set-shifting, central coherence, and decision making in currently ill and recovered women
    Unna N Danner
    Altrecht Eating Disorders Rintveld, Altrecht Mental Health Institute, The Netherlands
    Int J Eat Disord 45:685-94. 2012
    ..of this study is to examine set-shifting, central coherence, and decision making in women currently ill with anorexia nervosa (AN), women recovered from AN, and healthy control women...
  45. ncbi Impulsivity in women with eating disorders: problem of response inhibition, planning, or attention?
    Lindsay Rosval
    Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada
    Int J Eat Disord 39:590-3. 2006
    ..However, studies have not exhaustively explored the association between EDs and various component dimensions of the impulsivity construct...
  46. ncbi Specialist supportive clinical management for anorexia nervosa
    Virginia V W McIntosh
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Int J Eat Disord 39:625-32. 2006
    This article presents the rationale for, and description of, a nonspecialized therapy for anorexia nervosa, called specialist supportive clinical management (SSCM).
  47. pmc Animal models of eating disorders
    S F Kim
    Center for Neurobiology and Behavior, Department of Psychiatry and Pharmacology, The Perelman School of Medicine University of Pennsylvania, 125 S 31st St, TRL Rm 2207, Philadelphia, PA 19104, USA
    Neuroscience 211:2-12. 2012
    ..However, our understanding of eating disorders, such as anorexia nervosa, bulimia nervosa, and binge eating, is still poor...
  48. pmc Altered insula activation during pain anticipation in individuals recovered from anorexia nervosa: evidence of interoceptive dysregulation
    Irina A Strigo
    Department of Psychiatry, University of California San Diego, 3350 La Jolla Village Dr, Building 13, MC 9151 B, La Jolla, CA 92161, USA
    Int J Eat Disord 46:23-33. 2013
    Recent evidence raises the possibility that symptoms of anorexia nervosa (AN) could be related to impaired interoception...
  49. pmc Nothing tastes as good as skinny feels: the neurobiology of anorexia nervosa
    Walter H Kaye
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Trends Neurosci 36:110-20. 2013
    Individuals with anorexia nervosa (AN) engage in relentless restrictive eating and often become severely emaciated. Because there are no proven treatments, AN has high rates of relapse, chronicity, and death...
  50. ncbi Out-patient psychological therapies for adults with anorexia nervosa: randomised controlled trial
    Ulrike Schmidt
    Section of Eating Disorders, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Br J Psychiatry 201:392-9. 2012
    Very limited evidence is available on how to treat adults with anorexia nervosa and treatment outcomes are poor. Novel treatment approaches are urgently needed.
  51. ncbi Perinatal outcomes and gestational weight gain in women with eating disorders: a population-based cohort study
    N Micali
    Behavioural and Brain Sciences Unit, UCL Institute of Child Health, London, UK
    BJOG 119:1493-502. 2012
    To investigate adverse perinatal outcomes and gestational weight gain trajectories in women with lifetime (current/past) eating disorders (ED: anorexia nervosa [AN] and bulimia nervosa [BN]).
  52. ncbi Is anorexia nervosa a version of autism spectrum disorders?
    Anna Oldershaw
    Section of Eating Disorders, Division of Psychological Medicine and Psychiatry, King s College London, UK
    Eur Eat Disord Rev 19:462-74. 2011
    Similarities have been noted between cognitive profiles of anorexia nervosa (AN) and autism spectrum disorders (ASD). However, there are no direct comparison studies...
  53. ncbi The effectiveness of enhanced cognitive behavioural therapy for eating disorders: an open trial
    Susan M Byrne
    University of Western Australia School of Psychology, 35 Stirling Highway Crawley, 6009 Perth, Western Australia, Australia
    Behav Res Ther 49:219-26. 2011
    ..Overall, the findings indicated that CBT-E results in significant improvements, in both eating and more general psychopathology, in patients with all eating disorders attending an outpatient clinic...
  54. ncbi Attention, executive functions, and mentalizing in anorexia nervosa eighteen years after onset of eating disorder
    I Carina Gillberg
    Institute of Neuroscience and Physiology, Child and Adolescent Psychiatry, University of Gothenburg, Gothenburg, Sweden
    J Clin Exp Neuropsychol 32:358-65. 2010
    Prospective study of attention, executive functions, and mentalizing abilities in a representative sample of teenage-onset anorexia nervosa (AN).
  55. ncbi Neural correlates of body dissatisfaction in anorexia nervosa
    Hans Christoph Friederich
    Eating Disorders Unit, Institute of Psychiatry, King s College London, DeCrespigny Park, SE5 8AF London, UK
    Neuropsychologia 48:2878-85. 2010
    Body dissatisfaction is an important precipitating and maintenance factor in anorexia nervosa (AN) and behavioral studies suggest that a cognitive-affective component and a perceptual component (perceptual disturbance of one's own body) ..
  56. pmc A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa
    K Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Mol Psychiatry 16:949-59. 2011
    b>Anorexia nervosa (AN) is a mental illness with high mortality that most commonly afflicts adolescent female individuals. Clinical symptoms include chronic food refusal, weight loss and body image distortions...
  57. ncbi Neuronal activity changes and body image distortion in anorexia nervosa
    Angela Wagner
    Department of Child and Adolescent Psychiatry and Psychotherapy, Mannheim, Germany
    Neuroreport 14:2193-7. 2003
    Body image distortion is a major and often persistent symptom in anorexia nervosa. During a functional imaging investigation we confronted female anorectic patients and healthy controls with their own digitally distorted body images using ..
  58. ncbi Anorexia nervosa and autism spectrum disorders: guided investigation of social cognitive endophenotypes
    Nancy L Zucker
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychol Bull 133:976-1006. 2007
    Death by suicide occurs in a disproportionate percentage of individuals with anorexia nervosa (AN), with a standardized mortality ratio indicating a 57-fold greater risk of death from suicide relative to an age-matched cohort...
  59. ncbi Incidence, prevalence and mortality of anorexia nervosa and other eating disorders
    Hans Wijbrand Hoek
    Parnassia Psychiatric Institute, The Hague, The Netherlands
    Curr Opin Psychiatry 19:389-94. 2006
    ..The purpose of this review is to evaluate the recent literature on the incidence and prevalence of and mortality associated with eating disorders...
  60. pmc Neural correlates of viewing photographs of one's own body and another woman's body in anorexia and bulimia nervosa: an fMRI study
    Silja Vocks
    Department of Clinical Psychology and Psychotherapy, Ruhr University Bochum, Germany
    J Psychiatry Neurosci 35:163-76. 2010
    In spite of many similarities in the psychopathology of anorexia nervosa (AN) and bulimia nervosa (BN), the 2 groups seem to differ in terms of body image disturbances...
  61. ncbi Neural correlates of impaired cognitive-behavioral flexibility in anorexia nervosa
    Arne Zastrow
    Centre for Psychosocial Medicine, University Hospital Heidelberg, Department of Psychosomatic and General Internal Medicine, Thibautstr 2, 69115 Heidelberg, Germany
    Am J Psychiatry 166:608-16. 2009
    Impaired cognitive-behavioral flexibility is regarded as a trait marker in anorexia nervosa patients. The authors sought to investigate the neural correlates of this deficit in executive functioning in anorexia nervosa.
  62. ncbi Elevated peptide YY levels in adolescent girls with anorexia nervosa
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:1027-33. 2006
    ..b>Anorexia nervosa (AN) is associated with a deliberate reduction in food intake and low bone density, but endocrine modulators ..
  63. pmc Differential neural responses to food images in women with bulimia versus anorexia nervosa
    Samantha J Brooks
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e22259. 2011
    ..However, despite clinical differences in their responses to food, differential neural activation to thinking about eating food, between women with anorexia nervosa (AN) and bulimia nervosa (BN) is not known.
  64. ncbi A cross-sectional and follow-up voxel-based morphometric MRI study in adolescent anorexia nervosa
    Josefina Castro-Fornieles
    Department of Child and Adolescent Psychiatry and Psychology, Institute Clinic of Neurosciences, Hospital Clinic, University of Barcelona, Centro de Investigación Biomédica en Red de Salud Mental CIBER sam, Barcelona, Spain
    J Psychiatr Res 43:331-40. 2009
    The objective was to examine whether cerebral volumes are reduced, and in what regions, in adolescents with anorexia nervosa and to study changes after nutritional recovery...
  65. pmc Young women with cold-activated brown adipose tissue have higher bone mineral density and lower Pref-1 than women without brown adipose tissue: a study in women with anorexia nervosa, women recovered from anorexia nervosa, and normal-weight women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Yawkey 6E, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E584-90. 2012
    b>Anorexia nervosa (AN) is associated with depletion of body fat, loss of bone mineral density (BMD), and impaired thermogenesis. Brown adipose tissue (BAT) is lower in obese individuals and decreases during aging...
  66. ncbi Development of emotion acceptance behavior therapy for anorexia nervosa: a case series
    Jennifer E Wildes
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Int J Eat Disord 44:421-7. 2011
    ..describes the development of a novel psychotherapeutic intervention for older adolescents and adults with anorexia nervosa (AN)...
  67. ncbi The development of the P-CAN, a measure to operationalize the pros and cons of anorexia nervosa
    Lucy Serpell
    Department of Mental Health, St Georges Hospital Medical School, London, UK
    Int J Eat Disord 36:416-33. 2004
    Research has suggested that a fundamental aspect of anorexia nervosa (AN) is its egosyntonic nature, the fact that it is often valued by individuals with the disorder...
  68. ncbi Changes in regional fat redistribution and the effects of estrogen during spontaneous weight gain in women with anorexia nervosa
    S Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 73:865-9. 2001
    b>Anorexia nervosa is a disease of severe acquired undernutrition with a high and increasing prevalence among young women in the United States.
  69. ncbi Severe anorexia nervosa: outcomes from a medical stabilization unit
    Jennifer L Gaudiani
    University of Colorado Denver, Denver, Colorado, USA
    Int J Eat Disord 45:85-92. 2012
    We report data from the medical stabilization and refeeding of patients with severe anorexia nervosa admitted over a 15-month period.
  70. ncbi Functional and effective connectivity of anterior insula in anorexia nervosa and bulimia nervosa
    Kyung Ran Kim
    Department of Psychiatry, Yonsei University College of Medicine, South Korea
    Neurosci Lett 521:152-7. 2012
    ..However, it is still poorly understood how the anterior insula is involved in anorexia nervosa (AN) and bulimia nervosa (BN), which are characterized by opposite motivational responses to food...
  71. ncbi Dropout from inpatient treatment for anorexia nervosa: critical review of the literature
    Jenny Wallier
    Department of Psychiatry, Institut Mutualiste Montsouris, Paris, France
    Int J Eat Disord 42:636-47. 2009
    High dropout rates from inpatient treatment for Anorexia Nervosa (AN) pose a serious obstacle to successful treatment...
  72. ncbi Adolescent-onset anorexia nervosa: 18-year outcome
    Elisabet Wentz
    Institute of Neuroscience and Physiology, Child and Adolescent Psychiatry, Goteborg University, Otterhällegatan 12 B, SE 411 18 Göteborg, Sweden
    Br J Psychiatry 194:168-74. 2009
    The long-term outcome of anorexia nervosa is insufficiently researched.
  73. ncbi Body size perception in anorexia nervosa: a signal detection approach
    M A Smeets
    Department of Psychonomics, Utrecht University, The Netherlands
    J Psychosom Res 46:465-77. 1999
    This study investigated whether individuals with anorexia nervosa (AN) visualize themselves as fatter than they are because they perceive themselves as fatter...
  74. ncbi Marked increases in bone mineral density and biochemical markers of bone turnover in patients with anorexia nervosa gaining weight
    Ombretta Viapiana
    Department of Rheumathology, University of Verona, Valeggio Hospital, 37067 Valeggio S Mincio, Verona, Italy
    Bone 40:1073-7. 2007
    b>Anorexia nervosa (AN) is a life-threatening eating disorder characterized by an inability to maintain a normal body weight and amenorrhoea, often associated with osteoporosis and increased risk of fragility fractures...
  75. ncbi Increased brain histamine H1 receptor binding in patients with anorexia nervosa
    Masahiko Yoshizawa
    Department of Psychosomatic Medicine, Tohoku University School of Medicine, Japan
    Biol Psychiatry 65:329-35. 2009
    ..We hypothesized that women have higher density of histamine H1 receptor (H1R) in the limbic system than men and that the density of central H1R is increased in patients with anorexia nervosa (AN).
  76. ncbi A systematic review of impulsivity in eating disorders
    Samantha E Waxman
    Department of Psychology, Queen s University, Kingston, Canada
    Eur Eat Disord Rev 17:408-25. 2009
    ..The current findings have important clinical implications for our understanding and treatment of both impulsivity and eating disorders...
  77. ncbi Female adolescents with anorexia nervosa and their parents: a case-control study of exercise attitudes and behaviours
    Caroline Davis
    Department of Kinesiology and Health Sciences, York University, Toronto, ON, Canada
    Psychol Med 35:377-86. 2005
    Few studies of physical activity in patients with anorexia nervosa (AN) have included a suitable control group. Nor has such research considered the influence of parents' activity on that of their children...
  78. ncbi Medical complications in adolescents with anorexia nervosa: a review of the literature
    Debra K Katzman
    Division of Adolescent Medicine, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    Int J Eat Disord 37:S52-9; discussion S87-9. 2005
    ..the evidence-based medical complications and treatments that are both common and unique to adolescents with anorexia nervosa (AN)...
  79. ncbi Cognitive function and brain structure in females with a history of adolescent-onset anorexia nervosa
    Harold T Chui
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Pediatrics 122:e426-37. 2008
    Abnormalities in cognitive function and brain structure have been reported in acutely ill adolescents with anorexia nervosa, but whether these abnormalities persist or are reversible in the context of weight restoration remains unclear...
  80. ncbi Altered insula response to taste stimuli in individuals recovered from restricting-type anorexia nervosa
    Angela Wagner
    Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 33:513-23. 2008
    b>Anorexia nervosa (AN) is an illness characterized by aversion to ingestion of normally palatable foods...
  81. ncbi Aspects of social cognition in anorexia nervosa: affective and cognitive theory of mind
    Tamara Anne Russell
    Section of Neuroscience and Emotion, King s College London, Institute of Psychiatry, London, UK
    Psychiatry Res 168:181-5. 2009
    Although social functioning is clearly impaired in anorexia nervosa (AN), there has been limited empirical assessment of this domain in this illness...
  82. ncbi Attentional biases and frontal functioning in anorexia nervosa
    Secondo Fassino
    Department of Neurosciences, Psychiatry Section, Service for Eating Disorders, Turin University, Turin, Italy
    Int J Eat Disord 31:274-83. 2002
    ..such as abstraction, use of strategy, and response flexibility (focused attention) seen in patients with anorexia nervosa. The aim was to highlight any correlation between neuropsychological functioning and the degree of pathology ..
  83. ncbi Spatial orientation constancy is impaired in anorexia nervosa
    Dewi Guardia
    UDSL, EA4559, F 59000 Lille, France
    Psychiatry Res 195:56-9. 2012
    In anorexia nervosa (AN), body distortions have been associated with parietal cortex (PC) dysfunction. The PC is also the anatomical substrate of a supramodal reference framework involved in spatial orientation constancy...
  84. ncbi Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 289:E347-56. 2005
    ..Secretory dynamics of ghrelin have not been characterized in adolescents with anorexia nervosa (AN)...
  85. ncbi Childhood obsessive-compulsive personality traits in adult women with eating disorders: defining a broader eating disorder phenotype
    Marija Brecelj Anderluh
    Institute of Psychiatry, King College London, De Crespigny Park
    Am J Psychiatry 160:242-7. 2003
    ..The authors retrospectively examined a spectrum of childhood traits that reflect obsessive-compulsive personality in adult women with eating disorders and assessed the predictive value of the traits for the development of eating disorders...
  86. ncbi Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa
    Malgorzata Janas-Kozik
    Department and Clinic of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, ul Ziolowa 45 47, 40 635 Katowice, Poland
    Regul Pept 140:43-6. 2007
    ..aim of the study is to analyze the total ghrelin plasma level in patients suffering from restrictive type of anorexia nervosa (AN-R)...
  87. ncbi Visual body perception in anorexia nervosa
    Cosimo Urgesi
    Department of Human Sciences, University of Udine, Udine, Italy
    Int J Eat Disord 45:501-11. 2012
    Disturbance of body perception is a central aspect of anorexia nervosa (AN) and several neuroimaging studies have documented structural and functional alterations of occipito-temporal cortices involved in visual body processing...
  88. ncbi L-tri-iodothyronine is a major determinant of resting energy expenditure in underweight patients with anorexia nervosa and during weight gain
    Simone Onur
    Institut fur Humanernahrung und Lebensmittelkunde, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    Eur J Endocrinol 152:179-84. 2005
    We aimed to define the effect of L-3,5,3'-tri-iodothyronine (T(3)) on metabolic adaptation in underweight patients with anorexia nervosa (AN) as well as during weight gain.
  89. ncbi Incomplete restoration of the secretion of ghrelin and PYY compared to insulin after food ingestion following weight gain in anorexia nervosa
    Toshihiro Nakahara
    Department of Behavioral Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, 8 35 1, Sakuragaoka, Kagoshima City 890 8520, Japan
    J Psychiatr Res 41:814-20. 2007
    ..We investigated pre- and postprandial responses of ghrelin and PYY in anorexia nervosa (AN) and the influence of weight gain.
  90. ncbi Body image distortion reveals amygdala activation in patients with anorexia nervosa -- a functional magnetic resonance imaging study
    Gert Seeger
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, P O Box 12 21 20, 68072 Mannheim, Germany
    Neurosci Lett 326:25-8. 2002
    In anorexia nervosa patients, body image distortion is a core and often persistent symptom, which continues to pose a risk for relapse even after weight recovery...
  91. ncbi Do adolescent anorexia nervosa patients have deficits in emotional functioning?
    M J S Zonnevijlle-Bender
    Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, The Netherlands
    Eur Child Adolesc Psychiatry 11:38-42. 2002
    ..It was concluded that adolescent eating disorder patients, just like adult eating disorder patients, are characterised by alexithymia and show specific deficits in emotional functioning. The implications of these findings are discussed...
  92. ncbi Altered reward processing in women recovered from anorexia nervosa
    Angela Wagner
    University of Pittsburgh, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:1842-9. 2007
    Individuals with anorexia nervosa are known to be ascetic and able to sustain self-denial of food as well as most comforts and pleasures in life...
  93. pmc Dysregulation of brain reward systems in eating disorders: neurochemical information from animal models of binge eating, bulimia nervosa, and anorexia nervosa
    Nicole M Avena
    University of Florida, College of Medicine, Department of Psychiatry, Gainesville, FL 32608, USA
    Neuropharmacology 63:87-96. 2012
    ..of reward-related brain dysfunctions obtained through animal models of binge eating, bulimia nervosa, or anorexia nervosa. The findings suggest that alterations in dopamine (DA), acetylcholine (ACh) and opioid systems in reward-..
  94. ncbi Towards a neurocircuitry in anorexia nervosa: evidence from functional neuroimaging studies
    Kris van Kuyck
    Laboratory for Experimental Functional Neurosurgery, Department of Neurosciences, K U Leuven Provisorium I, Minderbroedersstraat 17, 3000 Leuven, Belgium
    J Psychiatr Res 43:1133-45. 2009
    ..SPECT), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) studies in anorexia nervosa (AN), a difficult-to-treat eating disorder with the highest mortality rate among psychiatric disorders...
  95. ncbi Effect of nutritional rehabilitation on circulating ghrelin and growth hormone levels in patients with anorexia nervosa
    Muneki Tanaka
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, Sakuragaoka 8 35 1, Kagoshima City 890 8520, Japan
    Regul Pept 122:163-8. 2004
    Circulating ghrelin and growth hormone (GH) are up-regulated in anorexia nervosa (AN) as a consequence of prolonged starvation...
  96. ncbi Neural processing of negative word stimuli concerning body image in patients with eating disorders: an fMRI study
    Yoshie Miyake
    Hiroshima University Health Service Center, Hiroshima, Japan
    Neuroimage 50:1333-9. 2010
    ..measured using functional magnetic resonance imaging in 36 patients with EDs (12 with the restricting type anorexia nervosa; AN-R, 12 with the binging-purging type anorexia nervosa; AN-BP, and 12 with bulimia nervosa; BN) and 12 ..
  97. ncbi Physical activity and exercise dependence during inpatient treatment of longstanding eating disorders: an exploratory study of excessive and non-excessive exercisers
    Solfrid Bratland-Sanda
    Research Institute, Modum Bad Psychiatric Center, Vikersund, Norway
    Int J Eat Disord 43:266-73. 2010
    ....
  98. ncbi Modulation of adiponectin and leptin during refeeding of female anorexia nervosa patients
    Dalit Modan-Moses
    Pediatric Endocrinology Unit, Division of Pediatrics, Chaim Sheba Medical Center, Tel Hashomer, 52621 Israel
    J Clin Endocrinol Metab 92:1843-7. 2007
    Several studies assessed adiponectin levels in anorexia nervosa (AN) patients, however, data regarding the dynamics of changes in adiponectin levels during refeeding of these patients is limited and contradicting.
  99. ncbi Physical activity and body composition in outpatients recovering from anorexia nervosa and healthy controls
    Tanja Hechler
    Department of Psychological Medicine, University of Sydney, Australia
    Adapt Phys Activ Q 25:159-73. 2008
    ..physical activity and body composition, and seasonal variation in physical activity in outpatients with anorexia nervosa (AN) and healthy controls...
  100. ncbi Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa
    Jean L Chan
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Stoneman 816, Boston, MA 02215, USA
    Lancet 366:74-85. 2005
    ..Disease states such as exercise-induced hypothalamic amenorrhoea and anorexia nervosa are also associated with low concentrations of leptin and a similar spectrum of neuroendocrine abnormalities...
  101. ncbi Set shifting in anorexia nervosa: an examination before and after weight gain, in full recovery and relationship to childhood and adult OCPD traits
    K Tchanturia
    Eating Disorders Research Unit, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    J Psychiatr Res 38:545-52. 2004
    Deficits in set shifting tasks are present in anorexia nervosa (AN), but it is not known whether these deficits are traits independent of current disease or nutritional status or merely a temporary consequence of starvation or ..

Research Grants72

  1. Symptoms, Serotonin and Amino Acids in Anorexia Nervosa
    David Jimerson; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Project Summary: Anorexia nervosa (AN) is a serious psychiatric disorder resulting in psychosocial distress for patients and their families, potentially severe medical consequences, and ..
  2. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Adolescent girls with anorexia nervosa (AN) exhibit hormonal abnormalities that predispose to alterations in bone turnover, accrual, and modeling that can ultimately lead to irreversible skeletal ..
  3. Monoamine Contributions to Neurocircuitry in Eating Disorders
    Walter H Kaye; Fiscal Year: 2013
    ..of serotonin (5-HT) and dopamine (DA) activity may contribute to extremes of appetitive behaviors in anorexia nervosa (AN) and bulimia nervosa (BN), through effects on inhibitory and reward neural pathways...
  4. Appetite-regulating Hormones and Neurocircuitry in Anorexia Nervosa
    ELIZABETH AUSTEN LAWSON; Fiscal Year: 2013
    ..approach to understanding endocrine factors and neurocircuitry underlying appetite and eating behavior in anorexia nervosa (AN)...
  5. CONTROL OF GONADOTROPIN SECRETION DURING LACTATION
    Kevin L Grove; Fiscal Year: 2013
    ..provided by applicant): It is firmly established that states of energy deficiency, such as fasting, anorexia nervosa, cachexia, bulimia, lactation and exercise-induced amenorrhea, as well as states of energy overabundance, ..
  6. Role of Neuropeptide Y in Obesity-Receptor Specific Analogs
    Ambikaipakan Balasubramaniam; Fiscal Year: 2013
    ..Patients with anorexia nervosa and bulimia had abnormal levels of NPY in the cerebrospinal fluid, which returned to normal on treatment...
  7. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    ..treatment in a large number of clinical situations, including cancer chemotherapy, diabetic gastroparesis, anorexia nervosa, ischemic gastropathy, chronic intestinal obstruction, abdominal malignancy, and functional dyspepsia...
  8. Anorexia Nervosa: Regional Brain Abnormalites and Relationship to Outcome
    LAURIE MAY MCCORMICK; Fiscal Year: 2013
    ..McCormick will obtain expertise in the neuroimaging and neuropsychological assessment of patients with anorexia nervosa (AN) and how these measures relate to illness course and treatment response...
  9. Endogenous G-Protein Coupled Receptor Antagonists
    Carrie Haskell-Luevano; Fiscal Year: 2012
    ..An AGRP polymorphism has been identified in humans diagnosed with anorexia nervosa, linking AGRP with a human physiological disease state...
  10. Brain Reward Circuits and Computational Modeling in Adolescent Anorexia Nervosa
    GUIDO KW FRANK; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anorexia nervosa (AN) is the third most common chronic illness among adolescents, and its mortality rate is 12 times higher than the death rate associated with all causes of death for females 15-24 ..
  11. Empirical eating disorder classification and validation using prospective studies
    Nadia Micali; Fiscal Year: 2013
    ..1-1% have anorexia nervosa and 1-3% have bulimia nervosa...
  12. Estradiol, MCH and Food Intake
    Jessica C Santollo; Fiscal Year: 2010
    ..including humans, has emerged as a putative, biological risk factor for eating disorders in general, and anorexia nervosa in particular...
  13. Gustatory Control of Sodium Appetite
    Ralph Norgren; Fiscal Year: 2012
    ..is key in developing rationale therapies for a broad spectrum of maladies such as drug addiction, obesity, anorexia nervosa, and depression...
  14. Biomarkers of Interoceptive Awareness in Adolescent Anorexia Nervosa
    NANCY L contact ZUCKER; Fiscal Year: 2010
    ..b>Anorexia nervosa (AN) is a terrifying and perplexing disorder...
  15. Interactions of dynorphin, NKB, and kisspeptin in control of GnRH secretion
    Michael N Lehman; Fiscal Year: 2013
    ..pathologies, including amenorrhea, polycystic ovarian syndrome (PCOS), and infertility associated with anorexia nervosa. Despite the long-standing recognition of the importance and functions of the GnRH neuroendocrine system, a ..
  16. Common and Distinct Phenotypes of Body Dysmorphic Disorder and Anorexia Nervosa
    Jamie Feusner; Fiscal Year: 2013
    ..study is to characterize shared and unique brain circuits associated with Body Dysmorphic Disorder (BDD) and Anorexia Nervosa (AN) using a set of functional neuroimaging experiments...
  17. Kappa Opioid Receptor Imaging in Anorexia
    Alexander Neumeister; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anorexia nervosa (AN) is a serious mental illness that is characterized by two primary features: (a) intense disgust associated with eating leading to difficulty maintaining healthy weight, (b) ..
  18. Chemical Profiles of Brain Synapses at Ages Vulnerable to Activity-Based Anorexia
    Nicole C Barbarich-Marsteller; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Anorexia nervosa (AN) is a psychiatric illness with no accepted pharmacological treatment [1] and with one of the highest mortality rates among the mental illnesses (10-20%) [2-4]...
  19. CNS Pathways Regulating Ghrelin Effects on Body Weight
    Joel K Elmquist; Fiscal Year: 2012
    ..It is hoped that these studies will result in new targeted therapies to treat mood obesity, diabetes and eating disorders such as anorexia nervosa and bulimia nervosa.
  20. Epigenetic Mechanisms in the Perpetuation of Anorexia Nervosa-like Behavior
    Kellie L K Tamashiro; Fiscal Year: 2013
    DESCRIPTION (provided by applicant: Anorexia nervosa (AN) is a severe eating disorder with a very high relapse rate and mortality...
  21. Neural Dysfunction of Interoception in Adolescents Diagnosed with Anorexia Nervos
    AMANDA B GRETHE; Fiscal Year: 2010
    Individuals with anorexia nervosa (AN) have aberrant feeding behavior, disturbances of emotionality and impulse control, and have high rates of relapse after weight restoration1, 2. There is no proven treatment that reverses symptoms...
  22. Mechanism of HPA Axis Activation: Role of Nicotinic Acid Receptor in the Brain
    Jang H Youn; Fiscal Year: 2012
    ..that would substantially stimulate NA-R in various metabolic states, including starvation, diabetes, and anorexia nervosa. Interestingly, all of these metabolic states are characterized by activated HPA axis, but the underlying ..
  23. Modeling anorexia nervosa with human pluripotent stem cells
    Alysson R Muotri; Fiscal Year: 2013
    ..The overarching goal of this project is to identify the defining characteristics of disease neurons in Anorexia Nervosa (AN), in the course of addressing the interplay between risk conferring genetic variations, excess of ..
  24. Developmental Psychopathology of Restrictive and Binge Eating in Childhood
    STEPHANIE CHRISTINE ZERWAS; Fiscal Year: 2013
    ..Third, I will examine the impact of the addition of an anorexia nervosa polygenic risk index to inform trajectory and pathway models of children's restrictive eating in the ..
  25. Feeding Styles and Responsiveness in Mothers with Eating Disorders
    ELIZABETH RUTH HOFFMAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Eating disorders such as anorexia nervosa and bulimia nervosa represent a significant public health problem for young women in particular, affecting an estimated 2...
  26. The Role of PTH in the Low Bone Mass of Anorexia Nervosa
    POUNEH KHADEJEH FAZELI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) affects 0.5-1% of college-aged women in the US and is characterized by extreme, self- induced starvation...
  27. Evaluating the effect of brief interventions on effort to restrict dietary intake
    ANN FRANCES HAYNOS; Fiscal Year: 2013
    ..DR predicts development of both overweight and eating disorders. At its extreme, DR can develop into anorexia nervosa (AN), a serious and chronic disorder associated with considerable morbidity and lifetime mortality up to 20%...
  28. Using Technology to Improve Eating Disorders Treatment
    DENISE ELLA WILFLEY; Fiscal Year: 2013
    ..least 650 students from these campuses who screen positive for a DSM-5 clinical or subclinical ED (excluding anorexia nervosa, which warrants more intensive medical monitoring)...
  29. Engaging Latino Families in Eating Disorders Treatment
    Mae Lynn Reyes-Rodríguez; Fiscal Year: 2013
    ..from the National Institute of Mental Health to adapt a novel couple- based intervention for adults with anorexia nervosa for Latinos [UCAN: Uniting Couples (in the treatment of) Anorexia Nervosa]...
  30. Effects of Anorexia Nervosa on Peak Bone Mass
    Anne Klibanski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anorexia nervosa (AN) is an increasingly common disorder in adolescent girls, with a prevalence of 0.2 to 1.0% in Western societies...
  31. Neurobiology of Anorexia and Bulimia Nervosa
    Walter H Kaye; Fiscal Year: 2013
    ABSTRACT Individuals with anorexia nervosa (AN) and bulimia nervosa (BN) have aberrant feeding behavior, and disturbances of emotionality and impulse control...
  32. Family Therapy in the Treatment of Adolescent Anorexia Nervosa
    WILLIAM STEWART AGRAS; Fiscal Year: 2010
    ..provided by applicant): The long-term objective of this proposal is to enhance the treatment and outcome of anorexia nervosa (AN) and to develop a network of research and training centers to support innovative research in AN...
  33. Family Therapy in the Treatment of Adolescent Anorexia Nervosa
    D Blake Woodside; Fiscal Year: 2010
    ..provided by applicant): The long-term objective of this proposal is to enhance the treatment and outcome of anorexia nervosa (AN) and to develop a network of research and training centers to support innovative research in AN...
  34. Family Therapy in the Treatment of Adolescent Anorexia Nervosa
    DENISE ELLA WILFLEY; Fiscal Year: 2010
    ..provided by applicant): The long-term objective of this proposal is to enhance the treatment and outcome of anorexia nervosa (AN) and to develop a network of research and training centers to support innovative research in AN...
  35. Family Therapy in the Treatment of Adolescent Anorexia Nervosa
    Harry A Brandt; Fiscal Year: 2010
    ..provided by applicant): The long-term objective of this proposal is to enhance the treatment and outcome of anorexia nervosa (AN) and to develop a network of research and training centers to support innovative research in AN...
  36. NEURAL MECHANISMS OF ANOREXIA
    Alan G Watts; Fiscal Year: 2012
    ..PROJECT NARRATIVE Eating disorders, and anorexia nervosa in particular, are significant clinical problems that have poor outcomes; indeed, anorexia nervosa is one of ..
  37. Mood and Anxiety Subtypes in Anorexia Nervosa: Relevance to Treatment
    Jennifer E Wildes; Fiscal Year: 2012
    ..in patterns of co-morbid mood and anxiety psychopathology is related to treatment response in patients with anorexia nervosa (AN)...
  38. Biomechanical Stimulation &Skeletal Health in Adolescents with Anorexia Nervosa
    Amy D DiVasta; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anorexia nervosa is a chronic illness resulting in significant morbidity and mortality, including the compromised accrual of bone mass during adolescence...
  39. Long-term impact of higher vs. lower calorie refeeding in anorexia nervosa
    Andrea Garber; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary/Abstract Patients with Anorexia Nervosa (AN) can become medically unstable due to malnutrition and require hospitalization for re-feeding, or nutritional repletion...
  40. Clinical Research in Eating Disorders and Obesity
    DENISE ELLA WILFLEY; Fiscal Year: 2013
    ..Selected ongoing and pending awards include studies designed to test early interventions for adolescents with anorexia nervosa, an enhanced prevention approach for women at very high risk for developing eating disorders, and methods for ..
  41. Hormonal Factors in the Treatment of Anorexia Nervosa
    Anne Klibanski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anorexia nervosa is a disease characterized by severe loss of weight with increased morbidity...
  42. Effect of Killing or Removing GABA from NPY/AgRP Neurons
    Richard D Palmiter; Fiscal Year: 2013
    ..This research is relevant to a better understanding normal and addictive feeding behavior, neuronal plasticity, and diseases such as anorexia nervosa.
  43. Family Based Treatment for Young Adults with Anorexia Nervosa
    Eunice Yu Chen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) is a serious psychiatric illness with the highest mortality rate of any other psychiatric disorder. There is no established efficacious treatment for adult AN...
  44. Olanzapine Versus Placebo in Outpatients with Anorexia Nervosa
    Evelyn Attia; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) is a major mental illness associated with substantial morbidity and mortality...
  45. NEURAL BASIS OF TASTE ELICITED INGESTION AND REJECTION
    JOSEPH TRAVERS; Fiscal Year: 2009
    ..Diseases such as obesity, hypertension, anorexia nervosa and dysphagia all involve ingestive dysfunction...
  46. Phenomenology of Obsessive Compulsive Personality Disorder
    Anthony Pinto; Fiscal Year: 2012
    ..Project 3 will test whether a novel intervention, cognitive remediation therapy, with demonstrated success in anorexia nervosa and OCD, leads to improvement in OCPD severity, as well as executive and psychosocial functioning...
  47. Enhancing Treatment for Adult Anorexia Nervosa with a Couple-Based Approach
    Cynthia M Bulik; Fiscal Year: 2013
    ..by applicant): No single, conventional treatment has been shown to significantly benefit adults with anorexia nervosa (AN), which ranks among the leading causes of disability and premature death in young women...
  48. Distinct &Common Neural Correlates of Fear Disorders, OCD, &Eating Disorders
    Helen Blair Simpson; Fiscal Year: 2013
    ..across three psychiatric disorders: social anxiety disorder (SAD), obsessive-compulsive disorder (OCD), and anorexia nervosa (AN)...
  49. Interdisciplinary Study of Marrow Adiposity, Mineral Metabolism &Energy Balance
    CLIFFORD JAMES ROSEN; Fiscal Year: 2013
    ..Most importantly, in a translational model of chronic calorie restriction, anorexia nervosa (AN), we showed that MAT was markedly increased compared to young age-matched controls and was inversely ..
  50. IGF-1 and Bone Loss in Women with Anorexia Nervosa
    Anne Klibanski; Fiscal Year: 2010
    Project Summary Severe osteopenia is a prevalent complication of anorexia nervosa (AN), affecting over half of all women with this disease. Loss of bone mass occurs frequently and is often permanent...
  51. Feasibility of Combining Family and Cognitive Therapy to Prevent Chronic Anorexia
    James D Lock; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) usually begins during adolescence and is a serious psychiatric disorder associated with high morbidity, mortality, and economic cost...
  52. Physical Activity in Anorexia Nervosa
    B Timothy Walsh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) is a serious psychiatric illness for which prognostic factors remain unclear, no effective pharmacotherapy is established, and rates of relapse are high...
  53. Translational Research on Eating Disorders: Reward Systems
    B Timothy Walsh; Fiscal Year: 2012
    The eating disorders Anorexia Nervosa and Bulimia Nervosa are serious psychiatric illnesses that affect a significant number of women and that are associated with substantial morbidity and mortality...
  54. Multimodal Neuroimaging of Adolescents and Young Adults with Anorexia Nervosa
    Allan L Reiss; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) is a life-threatening psychiatric disorder characterized by severe weight loss, distorted thinking about weight and appearance, and minimization of health and emotional problems...
  55. Defining Remission and Recovery in Eating Disorders
    Anna M Bardone-Cone; Fiscal Year: 2013
    ..individuals compare with controls, remitted individuals, and individuals with an eating disorder diagnosis (anorexia nervosa or bulimia nervosa) on personality (e.g...
  56. 2/2-Adaptive Family Treatment for Adolescent Anorexia Nervosa
    James D Lock; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) is a serious disorder associated with significant psychiatric and medical morbidity and mortality and high treatment costs due to the use of intensive treatment...
  57. 1/2-Adaptive Family Treatment for Adolescent Anorexia
    Daniel le Grange; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) is a serious disorder associated with significant psychiatric and medical morbidity and mortality and high treatment costs due to the use of intensive treatment...
  58. Family Therapy for Adolescent Bulimia Nervosa
    Daniel le Grange; Fiscal Year: 2005
    ..study derives from the candidate's participation in the conduct of treatment studies for adolescents with anorexia nervosa at the Maudsley Hospital in London...
  59. iEAT: Information Technology to Enhance Anorexia Treatment
    Cynthia M Bulik; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Relapse and readmission rates after hospital-based treatment of anorexia nervosa (AN) are unacceptably high, placing a major financial, psychological, and social burden on patients and family members...
  60. Brain Reward-Pathway Function and Neurocomputational Modeling in Anorexia Nervosa
    GUIDO KW FRANK; Fiscal Year: 2012
    ..magnetic resonance brain imaging (fMRI) research in Eating Disorders, specifically Restricting Type Anorexia Nervosa (RAN), 2...
  61. Mentoring and Research in Adolescent Eating Disorders
    James D Lock; Fiscal Year: 2013
    ..test novel treatments for child and adolescent eating disorders, including enhancing a research network for anorexia nervosa research and dissemination;2) To promote translational research in the neurosciences in patient oriented ..
  62. NEUROENDOCRINE CONTROL OF ANTERIOR PITUITARY HORMONES
    RHONDA KINEMAN; Fiscal Year: 2006
    ..GH production which contribute to the pathophysiology of clinically relevant disorders such as malnutrition, anorexia nervosa, obesity and diabetes...
  63. SUBCORTICAL MODULATION OF THE DORSAL VAGAL COMPLEX
    Xueguo Zhang; Fiscal Year: 2002
    DESCRIPTION (applicant's abstract): Disorders of appetite and feeding (including anorexia nervosa and bulimia nervosa) can have a profound impact on the quality of life and may even contribute to or cause death...
  64. Web-Based Training in Eating Disorder Prevention for Dental Professionals
    Herbert Severson; Fiscal Year: 2007
    ..b>Anorexia nervosa, bulimia nervosa, and partial syndrome eating disorders are among the most prevalent mental health issues ..
  65. LONGITUDINAL STUDY OF ANOREXIA AND BULIMIA NERVOSA
    David Herzog; Fiscal Year: 1999
    b>Anorexia nervosa (AN) and bulimia nervosa (BN) are prevalent disorders in adolescent and young adult women and are associated with high rates of morbidity and mortality...
  66. LONGITUDINAL STUDY OF BONE DENSITY IN ANOREXIA NERVOSA
    MICHAEL PERTSCHUK; Fiscal Year: 1993
    We previously identified decreased bone density as a complication of anorexia nervosa. There are serious implications to this finding...
  67. UCAN: Uniting Couples (in the treatment of) Anorexia Nervosa
    Cynthia Bulik; Fiscal Year: 2009
    ..by applicant): This R01 is submitted in response to RFA-MH-07-090 Innovative Trials for the Treatment of Anorexia Nervosa in Late Adolescence and Adulthood...
  68. COGNITIVE RESPONSES TO MEALS IN EATING DISORDERS
    Katherine Halmi; Fiscal Year: 1991
    ..Disturbed eating behavior in the disorders of anorexia nervosa and bulimia nervosa continues long after the patients have returned to a normal weight and have ceased ..
  69. ANOREXIA NERVOSA: PREVALENCE, DETERMINANTS, TREATMENT
    PAUL GARFINKEL; Fiscal Year: 1980
    A major problem in identifying cases of anorexia nervosa in the non-clinical population has been the lack of a well-validated, reliable instrument to measure the symptoms of the disorder...