dementia

Summary

Summary: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.

Top Publications

  1. pmc A commentary on studies presenting projections of the future prevalence of dementia
    Sam Norton
    Institute of Public Health, University of Cambridge, Cambridge, UK
    BMC Public Health 13:1. 2013
  2. pmc Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
    Han Xiang Deng
    Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 477:211-5. 2011
  3. ncbi The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening
    Eneida Mioshi
    MRC Cognition and Brain Sciences Unit, University of Cambridge, Department of Clinical Neurosciences, Addenbrooke s Hospital, UK
    Int J Geriatr Psychiatry 21:1078-85. 2006
  4. pmc Monetary costs of dementia in the United States
    Michael D Hurd
    RAND, Santa Monica, CA 90401, USA
    N Engl J Med 368:1326-34. 2013
  5. ncbi Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Manuela Neumann
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 314:130-3. 2006
  6. ncbi Risk of dementia in diabetes mellitus: a systematic review
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Netherlands
    Lancet Neurol 5:64-74. 2006
  7. pmc A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II
    Fiona E Matthews
    MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge University, Cambridge, UK
    Lancet 382:1405-12. 2013
  8. pmc Amyloid deposition is associated with impaired default network function in older persons without dementia
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 63:178-88. 2009
  9. pmc Glucose levels and risk of dementia
    Paul K Crane
    Department of Medicine, University of Washington, Seattle, WA, USA
    N Engl J Med 369:540-8. 2013
  10. doi The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years
    Mariese A Hely
    Department of Neurology, Westmead Hospital, Westmead, New South Wales, Australia
    Mov Disord 23:837-44. 2008

Detail Information

Publications325 found, 100 shown here

  1. pmc A commentary on studies presenting projections of the future prevalence of dementia
    Sam Norton
    Institute of Public Health, University of Cambridge, Cambridge, UK
    BMC Public Health 13:1. 2013
    Population ageing over the first half of this century is likely to lead to dramatic increases in the prevalence of dementia. This will affect all regions of the world, but particularly developing regions...
  2. pmc Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
    Han Xiang Deng
    Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 477:211-5. 2011
    ..b>Dementia, usually of the frontotemporal lobar type, may occur in some ALS cases...
  3. ncbi The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening
    Eneida Mioshi
    MRC Cognition and Brain Sciences Unit, University of Cambridge, Department of Clinical Neurosciences, Addenbrooke s Hospital, UK
    Int J Geriatr Psychiatry 21:1078-85. 2006
    ..There is a clear need for brief, but sensitive and specific, cognitive screening instruments as evidenced by the popularity of the Addenbrooke's Cognitive Examination (ACE)...
  4. pmc Monetary costs of dementia in the United States
    Michael D Hurd
    RAND, Santa Monica, CA 90401, USA
    N Engl J Med 368:1326-34. 2013
    b>Dementia affects a large and growing number of older adults in the United States. The monetary costs attributable to dementia are likely to be similarly large and to continue to increase.
  5. ncbi Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Manuela Neumann
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 314:130-3. 2006
    ..TDP-43 represents the common pathologic substrate linking these neurodegenerative disorders...
  6. ncbi Risk of dementia in diabetes mellitus: a systematic review
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Netherlands
    Lancet Neurol 5:64-74. 2006
    The relation between diabetes and major types of dementia is controversial. This systematic review examines the incidence of dementia in people with diabetes mellitus...
  7. pmc A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II
    Fiona E Matthews
    MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge University, Cambridge, UK
    Lancet 382:1405-12. 2013
    The prevalence of dementia is of interest worldwide. Contemporary estimates are needed to plan for future care provision, but much evidence is decades old...
  8. pmc Amyloid deposition is associated with impaired default network function in older persons without dementia
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 63:178-88. 2009
    ....
  9. pmc Glucose levels and risk of dementia
    Paul K Crane
    Department of Medicine, University of Washington, Seattle, WA, USA
    N Engl J Med 369:540-8. 2013
    Diabetes is a risk factor for dementia. It is unknown whether higher glucose levels increase the risk of dementia in people without diabetes.
  10. doi The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years
    Mariese A Hely
    Department of Neurology, Westmead Hospital, Westmead, New South Wales, Australia
    Mov Disord 23:837-44. 2008
    ..b>Dementia is present in 83% of 20-year survivors...
  11. pmc Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study
    Rachel A Whitmer
    Division of Research, Kaiser Permanente, Oakland, CA 94612, USA
    BMJ 330:1360. 2005
    To evaluate any association between obesity in middle age, measured by body mass index and skinfold thickness, and risk of dementia later in life.
  12. ncbi Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
    Alfredo Ramirez
    Institute of Human Genetics, University of Cologne, 50931 Cologne, Germany
    Nat Genet 38:1184-91. 2006
    ..gene, ATP13A2, underlying an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia (PARK9, Kufor-Rakeb syndrome)...
  13. pmc Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and qualitative analyses
    Xiangfei Meng
    Department of Psychiatry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    PLoS ONE 7:e38268. 2012
    ..explains why individuals with higher IQ, education, or occupational attainment have lower risks of developing dementia, Alzheimer's disease (AD) or vascular dementia (VaD)...
  14. pmc A network diffusion model of disease progression in dementia
    Ashish Raj
    Department of Radiology, Weill Medical College of Cornell University, 515 E 71 Street, Suite S123, New York, NY 10044, USA
    Neuron 73:1204-15. 2012
    Patterns of dementia are known to fall into dissociated but dispersed brain networks, suggesting that the disease is transmitted along neuronal pathways rather than by proximity...
  15. pmc Vitamin D, cognition, and dementia: a systematic review and meta-analysis
    Cynthia Balion
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    Neurology 79:1397-405. 2012
    To examine the association between cognitive function and dementia with vitamin D concentration in adults.
  16. ncbi Mixed brain pathologies account for most dementia cases in community-dwelling older persons
    Julie A Schneider
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Center, 600 S Paulina Street, Suite 1022F, Chicago, IL 60612, USA
    Neurology 69:2197-204. 2007
    ..To examine the spectrum of neuropathology in persons from the Rush Memory and Aging Project, a longitudinal community-based clinical-pathologic cohort study...
  17. doi Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies
    K J Anstey
    Ageing Research Unit, Centre for Mental Health Research Medical School, Australian National University, Canberra, ACT, Australia
    Obes Rev 12:e426-37. 2011
    The relationship between body mass index (BMI) (in midlife and late-life) and dementia was investigated in meta-analyses of 16 articles reporting on 15 prospective studies. Follow-ups ranged from 3.2 to 36.0 years...
  18. doi Nitric oxide signaling in brain function, dysfunction, and dementia
    Joern R Steinert
    Neurotoxicity at the Synaptic Interface, MRC Toxicology Unit, University of Leicester, Leicester, UK
    Neuroscientist 16:435-52. 2010
    ..Abnormal NO signaling could therefore contribute to a variety of neurodegenerative pathologies such as stroke/excitotoxicity, Alzheimer's disease, multiple sclerosis, and Parkinson's disease...
  19. ncbi Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
    Miia Kivipelto
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Arch Neurol 62:1556-60. 2005
    Vascular risk factors play a role in the development of dementia, including Alzheimer disease (AD). However, little is known about the effect of body mass index and clustering of vascular risk factors on the development of dementia.
  20. ncbi BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer
    Luis Sanchez-Pulido
    Protein Design Group, Centro Nacional de Biotecnologia CNB CSIC, Cantoblanco E 28049, Madrid, Spain
    Trends Biochem Sci 27:329-32. 2002
    ..These include BRI(2), which is related to familial British and Danish dementia (FBD and FDD); Chondromodulin-I (ChM-I), related to chondrosarcoma; CA11, related to stomach cancer; and ..
  21. ncbi Mild cognitive impairment
    Serge Gauthier
    McGill Center for Studies in Aging, Douglas Hospital, Montreal, Quebec, Canada
    Lancet 367:1262-70. 2006
    ..mild cognitive impairment seem to remain stable or return to normal over time, but more than half progress to dementia within 5 years...
  22. ncbi Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study
    Constantine G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    JAMA 288:1475-83. 2002
    Mild cognitive impairment (MCI) may be a precursor to dementia, at least in some cases. Dementia and MCI are associated with neuropsychiatric symptoms in clinical samples...
  23. doi Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis
    Joost Witlox
    Department of Geriatric Medicine, Medical Center Alkmaar, Alkmaar, The Netherlands
    JAMA 304:443-51. 2010
    ..Delirium is a common and serious complication in elderly patients. Evidence suggests that delirium is associated with long-term poor outcome but delirium often occurs in individuals with more severe underlying disease...
  24. ncbi Clinical diagnostic criteria for dementia associated with Parkinson's disease
    Murat Emre
    Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Mov Disord 22:1689-707; quiz 1837. 2007
    b>Dementia has been increasingly more recognized to be a common feature in patients with Parkinson's disease (PD), especially in old age...
  25. ncbi Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls
    Emma J Burton
    The Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle, UK
    Brain 127:791-800. 2004
    ..impairment and neuropsychiatric symptoms are frequent in Parkinson's disease, with a 70% cumulative incidence of dementia. The aim of this cross-sectional study was to establish the pattern of cerebral atrophy on MRI in Parkinson's ..
  26. ncbi Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies
    Kaarin J Anstey
    Centre for Mental Health Research, School of Psychology, The Australian National University, Canberra, Australia
    Am J Epidemiol 166:367-78. 2007
    The authors assessed the association of smoking with dementia and cognitive decline in a meta-analysis of 19 prospective studies with at least 12 months of follow-up...
  27. ncbi The prevalence of frontotemporal dementia
    E Ratnavalli
    Department of Neurology, Addenbrooke s Hospital, University of Cambridge, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Neurology 58:1615-21. 2002
    To estimate the prevalence of frontotemporal dementia (FTD) and other degenerative early-onset dementias in a geographically defined population.
  28. ncbi Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
    N Engl J Med 346:476-83. 2002
    In cross-sectional studies, elevated plasma homocysteine levels have been associated with poor cognition and dementia. Studies of newly diagnosed dementia are required in order to establish whether the elevated homocysteine levels precede ..
  29. pmc Pathways linking late-life depression to persistent cognitive impairment and dementia
    Meryl A Butters
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Dialogues Clin Neurosci 10:345-57. 2008
    ..depression, cognitive impairment, cerebrovascular disease, and poor cognitive outcomes, including progressive dementia, especially Alzheimer's disease...
  30. doi Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease
    Adam S Fleisher
    Banner Alzheimer s Institute, 901 E Willetta St, Phoenix, AZ 85006, USA
    Arch Neurol 68:1404-11. 2011
    ....
  31. ncbi An active and socially integrated lifestyle in late life might protect against dementia
    Laura Fratiglioni
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Neurotec Department, Karolinska Institute and Stockholm Gerontology Research Center, Stockholm, Sweden
    Lancet Neurol 3:343-53. 2004
    The recent availability of longitudinal data on the possible association of different lifestyles with dementia and Alzheimer's disease (AD) allow some preliminary conclusions on this topic...
  32. pmc Automatic classification of MR scans in Alzheimer's disease
    Stefan Kloppel
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Brain 131:681-9. 2008
    ..Secondly, they perform well in the differential diagnosis of two different forms of dementia. Thirdly, the method is robust and can be generalized across different centres...
  33. doi Can cognitive exercise prevent the onset of dementia? Systematic review of randomized clinical trials with longitudinal follow-up
    Michael Valenzuela
    School of Psychiatry, University of New South Wales and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia
    Am J Geriatr Psychiatry 17:179-87. 2009
    Epidemiological and preclinical studies suggest that mental activity levels may alter dementia risk...
  34. ncbi Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease
    G M McKhann
    Department of Neurology, Zanvyl Krieger Mind Brain Institute, Johns Hopkins University School of Medicine, 338 Krieger Hall, 3400 N Charles St, Baltimore, MD 21218 2685, USA
    Arch Neurol 58:1803-9. 2001
    An international group of clinical and basic scientists participated in the Frontotemporal Dementia and Pick's Disease Criteria Conference at the National Institutes of Health in Bethesda, Md, on July 7, 2000, to reassess clinical and ..
  35. ncbi Influence of social network on occurrence of dementia: a community-based longitudinal study
    L Fratiglioni
    Stockholm Gerontology Research Centre, and Division of Geriatric Medicine, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Lancet 355:1315-9. 2000
    Few data are available on the effect of social ties on dementia development. This study explored whether single social network components and different degrees of the social connections affect dementia incidence.
  36. doi Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis
    Sarah T Pendlebury
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Lancet Neurol 8:1006-18. 2009
    Reliable data on the prevalence and predictors of post-stroke dementia are needed to inform patients and carers, plan services and clinical trials, ascertain the overall burden of stroke, and understand its causes...
  37. pmc Classification of primary progressive aphasia and its variants
    M L Gorno-Tempini
    Memory and Aging Center, Department of Neurology, UCSF, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143 1207, USA
    Neurology 76:1006-14. 2011
    ..Future collaborations will collect prospective data to identify relationships between each of these syndromes and specific biomarkers for a more detailed understanding of clinicopathologic correlations...
  38. ncbi Family caregiving of persons with dementia: prevalence, health effects, and support strategies
    Richard Schulz
    University Center for Social and Urban Research, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Am J Geriatr Psychiatry 12:240-9. 2004
    The authors summarize the dementia caregiving literature and provide recommendations regarding practice guidelines for health professionals working with caregivers...
  39. pmc Stages of use: consideration, initiation, utilization, and outcomes of an internet-mediated intervention
    Teresa M L Chiu
    Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hung Hom, PR China
    BMC Med Inform Decis Mak 10:73. 2010
    ..Utilization and Venkatesh's Unified Theory of Acceptance and Use of Technology, to explore the factors associated with uptake and use of an internet-mediated intervention for caregivers taking care of a family member with dementia.
  40. ncbi The age-dependent relation of blood pressure to cognitive function and dementia
    Chengxuan Qiu
    Aging Research Centre, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institute and Stockholm Gerontology Research Centre, Stockholm, Sweden
    Lancet Neurol 4:487-99. 2005
    The relation of blood pressure with cognitive function and dementia has, in recent years, received much attention from epidemiological research...
  41. ncbi The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study
    Francoise Forette
    Department of Geriatrics, Hopital Broca, CHU Cochin, University of Paris V, 54 56 Rue Pascal, 75013 Paris, France
    Arch Intern Med 162:2046-52. 2002
    ..After the double-blind, placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial ended in February 1997, randomized patients were offered active study medication for a further period of observation...
  42. ncbi Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline
    G Waldemar
    Memory Disorders Research Group, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Denmark
    Eur J Neurol 14:e1-26. 2007
    The aim of this international guideline on dementia was to present a peer-reviewed evidence-based statement for the guidance of practice for clinical neurologists, geriatricians, psychiatrists, and other specialist physicians responsible ..
  43. ncbi A systematic review of prevalence studies of dementia in Parkinson's disease
    Dag Aarsland
    Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway
    Mov Disord 20:1255-63. 2005
    Substantial variation in the prevalence of dementia in Parkinson's disease (PDD) has been reported...
  44. pmc Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women
    Gregory J Tranah
    California Pacific Medical Center Research Institute, San Francisco, CA 94107 1728, USA
    Ann Neurol 70:722-32. 2011
    Previous cross-sectional studies have observed alterations in activity rhythms in dementia patients but the direction of causation is unclear...
  45. doi The global prevalence of dementia: a systematic review and metaanalysis
    Martin Prince
    Institute of Psychiatry, King s College London, London, UK
    Alzheimers Dement 9:63-75.e2. 2013
    The evidence base on the prevalence of dementia is expanding rapidly, particularly in countries with low and middle incomes...
  46. doi Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial
    Sube Banerjee
    Institute of Psychiatry, Health Services and Population Research Department, King s College London, London, UK
    Lancet 378:403-11. 2011
    Depression is common in dementia but the evidence base for appropriate drug treatment is sparse and equivocal...
  47. ncbi Brain reserve and dementia: a systematic review
    Michael J Valenzuela
    The Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
    Psychol Med 36:441-54. 2006
    ..So far there have been several epidemiological reports but no systematic review to put conflicting results into context. Our aim was to quantitatively review evidence for the effect of brain reserve on incident dementia.
  48. doi Validity, reliability, and feasibility of a quality of life questionnaire for people with dementia
    M Dichter
    Deutsches Zentrum für Neurodegenerative Erkrankungen, Stockumer Str 12, 58453 Witten, Germany
    Z Gerontol Geriatr 44:405-10. 2011
    ..applicability of the German version of the QUALIDEM, which is used to measure the quality of life of people with dementia in nursing homes...
  49. doi Trends in antipsychotic use in dementia 1999-2007
    Helen C Kales
    Veterans Affairs Health Services Researchand Development Center for Clinical Management Research, Serious Mental Illness Treatment, Resource, and Evaluation Center, Ann Arbor, Michigan, USA
    Arch Gen Psychiatry 68:190-7. 2011
    Use of atypical antipsychotics for neuropsychiatric symptoms of dementia increased markedly in the 1990s...
  50. doi Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort
    N S M Schoonenboom
    Departments of Neurology, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands
    Neurology 78:47-54. 2012
    To determine how amyloid β 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) levels in CSF behave in a large cohort of patients with different types of dementia.
  51. ncbi Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia
    Chie Yasutake
    Department of Neuropsychiatry, Osaka Medical College, Daigakumachi 2 7, Takatsuki, Osaka, Japan
    Eur Arch Psychiatry Clin Neurosci 256:402-6. 2006
    ..However, little is known about in vivo BDNF in dementia patients. Moreover, the immunological function of neurotrophins such as BDNF has received great interest...
  52. pmc Neuropathologic substrates of Parkinson disease dementia
    David J Irwin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Morris K Udall Parkinson s Disease Center of Excellence, Institute on Aging, Philadelphia, PA, USA
    Ann Neurol 72:587-98. 2012
    A study was undertaken to examine the neuropathological substrates of cognitive dysfunction and dementia in Parkinson disease (PD).
  53. ncbi Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders
    Sara Hall
    Department of Clinical Sciences, Lund University
    Arch Neurol 69:1445-52. 2012
    To assess the ability of 5 cerebrospinal fluid(CSF) biomarkers to differentiate between common dementia and parkinsonian disorders.
  54. pmc Benzodiazepine use and risk of dementia: prospective population based study
    Sophie Billioti de Gage
    Université Bordeaux Segalen, F 33000 Bordeaux, France
    BMJ 345:e6231. 2012
    To evaluate the association between use of benzodiazepines and incident dementia.
  55. pmc Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?
    Yaroslau Compta
    Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 134:1493-505. 2011
    The relative importance of Lewy- and Alzheimer-type pathologies to dementia in Parkinson's disease remains unclear...
  56. ncbi A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia
    M Morita
    Day Neuromuscular Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Neurology 66:839-44. 2006
    To perform genetic linkage analysis in a family affected with ALS and frontotemporal dementia (FTD).
  57. pmc Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:20822-7. 2010
    ..to the prevailing "amyloid cascade hypothesis," genetic dementias such as Alzheimer's disease and familial Danish dementia (FDD) are caused by amyloid deposits that trigger tauopathy, neurodegeneration, and behavioral/cognitive ..
  58. ncbi Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications
    Carol Gregory
    Fulbourn Hospital, Cambridge, UK
    Brain 125:752-64. 2002
    ..We tested the hypothesis that the changes in personality and behaviour seen in frontal variant frontotemporal dementia (fvFTD) may reflect impairment in this cognitive domain...
  59. pmc Promising strategies for the prevention of dementia
    Laura E Middleton
    Department of Psychiatry, School of Medicine, University of California, San Francisco, San Francisco, CA 94121, USA
    Arch Neurol 66:1210-5. 2009
    The incidence and prevalence of dementia are expected to increase several-fold in the coming decades...
  60. pmc Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory
    Willem de Haan
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    BMC Neurosci 10:101. 2009
    ..All results were normalized for network size and compared with random control networks...
  61. ncbi Screening for dementia in primary care: a summary of the evidence for the U.S. Preventive Services Task Force
    Malaz Boustani
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Ann Intern Med 138:927-37. 2003
    b>Dementia is a large and growing problem but is often not diagnosed in its earlier stages. Screening and earlier treatment could reduce the burden of suffering of this syndrome.
  62. pmc PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
    Arch Neurol 66:352-61. 2009
    ....
  63. doi The worldwide societal costs of dementia: Estimates for 2009
    Anders Wimo
    KI Alzheimer s Disease Research Center, Department of Neurobiology, Karolinska Institutet, Stockholm, Sweden
    Alzheimers Dement 6:98-103. 2010
    The purpose of this study was to update the previous estimate of the worldwide cost of dementia in 2005 to 2009.
  64. pmc Prevalence of dementia in the United States: the aging, demographics, and memory study
    B L Plassman
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27701, USA
    Neuroepidemiology 29:125-32. 2007
    ..To estimate the prevalence of Alzheimer's disease (AD) and other dementias in the USA using a nationally representative sample...
  65. ncbi Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17
    M Hutton
    Mayo Clinic Jacksonville, Florida 32224, USA
    Nature 393:702-5. 1998
    Thirteen families have been described with an autosomal dominantly inherited dementia named frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), historically termed Pick's disease...
  66. ncbi Delirium in older persons
    Sharon K Inouye
    Department of Medicine, Harvard Medical School, Boston, USA
    N Engl J Med 354:1157-65. 2006
  67. doi Animal models of Alzheimer's disease and frontotemporal dementia
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    Nat Rev Neurosci 9:532-44. 2008
    Insoluble protein aggregates have been linked to Alzheimer's disease (AD) and frontotemporal dementia (FTD)...
  68. ncbi Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia
    Giuseppina Sessa
    Department of Neuroscience, DIBIT, Vita Salute San Raffaele University and San Raffaele Institute, Via Olgettina 58, 20132 Milan, Italy
    Eur J Neurosci 20:2617-28. 2004
    ..spectrum of pathological lesions in the cortex, thalamus and basal ganglia with clinical symptoms of progressive dementia (polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy)...
  69. ncbi Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study
    Laura Jean Podewils
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Epidemiol 161:639-51. 2005
    Physical activity may help preserve cognitive function and decrease dementia risk, but epidemiologic findings are inconsistent...
  70. pmc Vascular risk factors and dementia: how to move forward?
    Anand Viswanathan
    Department of Neurology and Clinical Trials Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neurology 72:368-74. 2009
    ..Vascular dementia had been traditionally considered secondary to stroke and vascular disease...
  71. ncbi The AD8: a brief informant interview to detect dementia
    J E Galvin
    Department of Neurology, Alzheimer Disease Research Center, Washington University, St Louis, MO 63108, USA
    Neurology 65:559-64. 2005
    Brief measures that accurately discriminate normal cognitive aging from very mild dementia are lacking. Cognitive tests often are insensitive to very mild dementia. Informant-based measures may be more sensitive in detecting early dementia...
  72. ncbi The role of tau (MAPT) in frontotemporal dementia and related tauopathies
    R Rademakers
    Department of Molecular Genetics, Neurogenetics Group, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
    Hum Mutat 24:277-95. 2004
    ..In patients diagnosed with frontotemporal dementia and parkinsonism linked to chromosome 17, mutations in the gene encoding tau (MAPT) have been identified that ..
  73. pmc Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL FL 32224, USA
    Hum Mol Genet 17:3631-42. 2008
    ..mutations in progranulin (GRN) cause ubiquitin- and TAR DNA-binding protein 43 (TDP-43)-positive frontotemporal dementia (FTLD-U), a progressive neurodegenerative disease affecting approximately 10% of early-onset dementia patients...
  74. ncbi Nonpharmacological cognitive interventions in aging and dementia
    Amarilis Acevedo
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, and Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida 33140, USA
    J Geriatr Psychiatry Neurol 20:239-49. 2007
    ..It is concluded that cognitive interventions in the elderly show considerable promise and deserve further study...
  75. doi Cognitive function, dementia and type 2 diabetes mellitus in the elderly
    Mark W J Strachan
    Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Nat Rev Endocrinol 7:108-14. 2011
    ..Cognitive impairment and dementia could come into this category. Type 2 diabetes mellitus is associated with a 1.5-2...
  76. pmc alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
    M G Spillantini
    Medical Research Council Centre for Brain Repair and Department of Neurology, University of Cambridge, Robinson Way, Cambridge CB2 2PY, United Kingdom
    Proc Natl Acad Sci U S A 95:6469-73. 1998
    Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition...
  77. pmc Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 86:876-84. 2011
    ..strongly suggests that exercise, specifically aerobic exercise, may attenuate cognitive impairment and reduce dementia risk...
  78. doi Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
    Peng Lei
    Mental Health Research Institute, The University of Melbourne, Victoria, Australia
    Nat Med 18:291-5. 2012
    ..These data suggest that the loss of soluble tau could contribute to toxic neuronal iron accumulation in Alzheimer's disease, Parkinson's disease and tauopathies, and that it can be rescued pharmacologically...
  79. ncbi Midlife cardiovascular risk factors and risk of dementia in late life
    R A Whitmer
    Kaiser Permanente Division of Research, 2000 Broadway, Oakland, CA 94612, USA
    Neurology 64:277-81. 2005
    To evaluate if midlife cardiovascular risk factors are associated with risk of late-life dementia in a large, diverse cohort.
  80. pmc Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study
    Daniel H J Davis
    Department of Public Health and Primary Care, University of Cambridge, UK
    Brain 135:2809-16. 2012
    Recent studies suggest that delirium is associated with risk of dementia and also acceleration of decline in existing dementia. However, previous studies may have been confounded by incomplete ascertainment of cognitive status at baseline...
  81. ncbi DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia
    E Kalbe
    Max Planck Institute for Neurological Research, Cologne, Germany
    Int J Geriatr Psychiatry 19:136-43. 2004
    To design a new, highly sensitive psychometric screening to identify patients with mild cognitive impairment (MCI) and patients with dementia in the early stages of the disease.
  82. doi Dementia in the acute hospital: prospective cohort study of prevalence and mortality
    Elizabeth L Sampson
    Marie Curie Palliative Care Research Unit, Department of Mental Health Sciences, University College Medical School, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK
    Br J Psychiatry 195:61-6. 2009
    Increasing numbers of people will die with dementia, many in the acute hospital. It is often not perceived to be a life-limiting illness.
  83. doi Central obesity and increased risk of dementia more than three decades later
    R A Whitmer
    Kaiser Permanente Division of Research, 2000 Broadway, Oakland, CA 94612, USA
    Neurology 71:1057-64. 2008
    ..No studies have evaluated whether the same pattern exists with dementia. The objective was to evaluate the association between midlife central obesity and risk of dementia three decades ..
  84. doi The granulin gene family: from cancer to dementia
    Andrew Bateman
    Endocrine Research Laboratory, McGill University Health Centre, Royal Victoria Hospital, Montreal, Canada
    Bioessays 31:1245-54. 2009
    ..mutation in GRN, the gene for PGRN, leads to neuronal atrophy in the frontal and temporal lobes, resulting in the disease frontotemporal lobar dementia. In this review we will discuss current knowledge of the multifaceted biology of PGRN.
  85. pmc Vascular basis for brain degeneration: faltering controls and risk factors for dementia
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Nutr Rev 68:S74-87. 2010
    ..to indicate vascular risk factors are also linked to neurodegenerative processes preceding cognitive decline and dementia. The strongest risk factor for brain degeneration, whether it results from vascular or neurodegenerative ..
  86. ncbi Defining mild cognitive impairment in Parkinson's disease
    John N Caviness
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA
    Mov Disord 22:1272-7. 2007
    ..or greater deficit upon neuropsychological testing consistently across at least one cognitive domain without dementia, and PD dementia (PD-D) using DSM-IV criteria...
  87. doi Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden
    Chengxuan Qiu
    Aging Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet Stockholm University, Stockholm, Sweden
    Neurology 80:1888-94. 2013
    To explore whether prevalence, survival, and incidence of dementia have changed from 1987-1994 to 2001-2008 in Stockholm, Sweden.
  88. doi Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990-2010: a systematic review and analysis
    Kit Yee Chan
    Nossal Institute for Global Health, University of Melbourne, Australia
    Lancet 381:2016-23. 2013
    ..We assessed the epidemiology of Alzheimer's disease and other forms of dementia in China between 1990, and 2010, to improve estimates of the burden of disease, analyse time trends, and inform ..
  89. doi Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease
    Annapaola Prestia
    LENITEM Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
    Neurology 80:1048-56. 2013
    ..The aim of this study is to provide clinical evidence of the model in patients with mild cognitive impairment (MCI)...
  90. doi Hypoglycaemic episodes and risk of dementia in diabetes mellitus: 7-year follow-up study
    C H Lin
    Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
    J Intern Med 273:102-10. 2013
    We investigated the risk of dementia in patients with type 2 diabetes with or without prior hypoglycaemic episodes.
  91. doi The association between physical activity and dementia in an elderly population: the Rotterdam Study
    Renée F A G de Bruijn
    Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 28:277-83. 2013
    Several studies have associated physical activity with the risk of dementia, but mostly did so during short follow-up. It remains unclear whether physical activity also affects dementia during longer follow-up...
  92. doi Cognitive disorders and dementia in CKD: the neglected kidney-brain axis
    Jean Marc Bugnicourt
    Service de Neurologie, CHU Amiens, Place Victor Pauchet F 80054, Amiens Cedex 1, France
    J Am Soc Nephrol 24:353-63. 2013
    ..data suggest that individuals at all stages of CKD have a higher risk of developing cognitive disorders and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic ..
  93. doi Pain treatment in elderly persons with and without dementia: a population-based study of institutionalized and home-dwelling elderly
    Ylva Haasum
    Aging Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet and Stockholm University, Stockholm, Sweden
    Drugs Aging 28:283-93. 2011
    Several previous studies have reported an undertreatment of pain in elderly persons with dementia. It has also been suggested that persons with dementia may be at risk for inappropriate treatment of pain with psychotropics.
  94. ncbi Living with early-stage dementia: a review of qualitative studies
    Els Steeman
    Center for Health Services and Nursing Research, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    J Adv Nurs 54:722-38. 2006
    This paper presents a literature review whose aim was to provide better understanding of living with early-stage dementia.
  95. doi Apart from nihilism and stigma: what influences general practitioners' accuracy in identifying incident dementia?
    Michael Pentzek
    Department of General Practice, University Medical Center Düsseldorf, Dusseldorf, Germany
    Am J Geriatr Psychiatry 17:965-75. 2009
    To assess the accuracy of the General Practitioner's (GP) judgment in the recognition of incident dementia cases and to explore factors associated with recognition.
  96. ncbi Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3
    Caroline Vance
    Department of Neurology, King s College London School of Medicine, London, UK
    Brain 129:868-76. 2006
    Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are both relentlessly progressive and ultimately fatal neurological disorders. ALS is familial in approximately 10% of cases and FTD in approximately 30%...
  97. doi Glucose tolerance status and risk of dementia in the community: the Hisayama study
    T Ohara
    Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Neurology 77:1126-34. 2011
    We investigated the association between glucose tolerance status defined by a 75-g oral glucose tolerance test (OGTT) and the development of dementia.
  98. pmc APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
    EMBO J 30:2501-9. 2011
    An autosomal dominant mutation in the BRI2/ITM2B gene causes familial Danish dementia (FDD)...
  99. doi Costs of care for dementia patients in community setting: an analysis for mild and moderate disease stage
    Larissa Schwarzkopf
    Helmholtz Zentrum München Institute of Health Economics and Health Care Management, Neuherberg, Germany
    Value Health 14:827-35. 2011
    Rising life expectancy is associated with higher prevalence rates of dementia disorders. When disease progresses the patients' call on formal health care services and on social support grows which imposes increasing costs of care...
  100. pmc β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
    EMBO Mol Med 4:171-9. 2012
    A mutation in the BRI2/ITM2b gene causes loss of BRI2 protein leading to familial Danish dementia (FDD)...
  101. pmc Depression and risk of developing dementia
    Amy L Byers
    Department of Psychiatry, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, 4150 Clement Street 116H, San Francisco, CA 94121, USA
    Nat Rev Neurol 7:323-31. 2011
    Depression is highly common throughout the life course and dementia is common in late life...

Research Grants87

  1. Survival and Comorbidities after Dementia
    Annette Fitzpatrick; Fiscal Year: 2003
    DESCRIPTION (provided by applicant) Estimation of survival following the onset of dementia is an extremely important public health issue as America ages. A recent study reported median survival after dementia to be 3...
  2. Validation of Measures of Restless Legs Syndrome for Elders with Memory Disorders
    Kathy Richards; Fiscal Year: 2009
    ..a valid objective method to diagnose a prevalent sleep disorder, restless legs syndrome (RLS), in elders with dementia. RLS is characterized by uncomfortable leg sensations that disturb sleep and are associated with significantly ..
  3. DELIRIUM IN PERSONS WITH DEMENTIA
    Donna Fick; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): By 2050, 14 million older persons in the United States are expected to have dementia. It is well known that persons with dementia are at increased risk of developing delirium or acute confusional ..
  4. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  5. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..typical and atypical antipsychotic drugs are widely used to treat the psychosis and agitation associated with dementia. The elderly population of veterans (which is dramatically increasing) is highly vulnerable to the untoward ..
  6. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
    ..In spite of this side-effect, the first reports form this trial suggested some success in slowing the rate of dementia progression in patients generating antibodies against brain A(...
  7. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dementia and other milder forms of cognitive diseases of the CNS affect HIV-1 infected patients...
  8. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..Alzheimer's is the most common form of dementia afflicting more than 5 million Americans...
  9. Drug Interactions at the Human Blood-Brain Barrier
    Jashvant D Unadkat; Fiscal Year: 2010
    ..on multitude of communities including people with Alzheimer's disease, brain tumors, HIV-associated dementia and the entire CNS drug development process in the pharmaceutical industry...
  10. Regulation of Astrocyte TIMP-1 in HIV-Associated Dementia
    JEREL ADAM FIELDS; Fiscal Year: 2011
    ..tissue inhibitors of metalloproteases (TIMP) expression during Human Immunodeficiency Virus (HIV)-associated dementia (HAD). HIV-associated neurocognitive disorders are a group of disorders of which HAD is the most severe...
  11. Role of TPH2 and 5HT Neuronal Loss in Non-motor Symptoms of Parkinson's
    Donald M Kuhn; Fiscal Year: 2012
    ..of PD patients suffer from co-morbid neuropsychiatric conditions like depression, sleep disorders, anxiety and dementia. Many of these conditions have been linked to dysfunctional 5HT neurochemistry...
  12. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infection with Human Immunodeficiency virus (HIV)-1 can induce dementia for which currently no treatment is available...
  13. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..castration', deficits that are reversible with simultaneous administration of E2, 4) the increased risk of dementia in premenopausal women who have had a bilateral oophorectomy, 5) the increased prevalence of cognitive disease in ..
  14. Development and Validation of an Instrument to Assess Cognitive Function Regulati
    Xi Chen; Fiscal Year: 2013
    ..which is essential to achieving his long- term goal -- development of a new evidence-based dental care model for dementia patients...
  15. Study of zidovudine addition in HIV-associated neurocognitive disorders
    Albert Anderson; Fiscal Year: 2013
    ..antiretrovirals in penetrating the CNS, and is historically the best studied antiretrovirl for HIV-associated dementia. The investigator's primary hypothesis is that the addition of zidovudine in antiretroviral-na[unreadable]ve ..
  16. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2012
    ..is primarily responsible for the characteristic parkinsonian movement disorder, non-motor disabilities including dementia, depression, gastrointestinal dysfunction, and autonomic instability arise from neurodegeneration elsewhere in ..
  17. Optimizing Chronic Disease Prevention and Management in Advanced Dementia
    Jennifer Tjia; Fiscal Year: 2010
    ..In this application, "Optimizing Chronic Disease Prevention and Management in Advanced Dementia", we propose to study the effectiveness of medication prophylaxis for chronic illness in the medically complex ..
  18. CHEMOSENSORY PERCEPTION AND PSYCHOPHYSICS IN THE AGED
    CLAIRE L MURPHY; Fiscal Year: 2013
    ..mortality, epidemic increase in middle-aged obesity with associated risk for cardiovascular disease, diabetes, dementia and "metabolic syndrome" is creating an enormous public health burden with grave implications for the next ..
  19. Muscle stem cell therapy in a mouse model of premature aging
    Johnny Huard; Fiscal Year: 2010
    ..an increased risk of numerous debilitating diseases and organ system failures including cardiovascular disease, dementia, bone fractures, sarcopenia, and cancer...
  20. Geriatric Conditions and Disablement in the Older Adult Population
    Christine T Cigolle; Fiscal Year: 2013
    ..The research will examine five geriatric conditions: dementia, falls, urinary incontinence, poor nutrition, and multisensory impairment...
  21. Glial-neuronal interactions underlying the molecular feedback between HIV viral p
    Sulie L Chang; Fiscal Year: 2013
    ..diseases and behavioral disorders, such as HIV-1 induced neurodegeneration (HAND) and HIV-1 induced dementia (HAD)...
  22. White matter changes in HIV models
    Pamela E Knapp; Fiscal Year: 2011
    ..syndrome, caused by human immunodeficiency virus-1 (HIV-1) infection, is the most common cause of dementia in non-aged individuals in the US...
  23. DYNAMICS OF THE NEURONAL CYTOSKELETON IN AGING BRAIN
    Ralph A Nixon; Fiscal Year: 2013
    ..In several major neurodegenerative diseases, including a form of fronto-temporal dementia, abnormal accumulations of NF are a neuropathologic hallmark believed to contribute to neuronal dysfunction...
  24. OLFACTORY RECEPTOR COPY NUMBER ASSOCIATION WITH AGE AT ONSET OF ALZHEIMER DISEASE
    Kinga Szigeti; Fiscal Year: 2013
    ..disorder affecting approximately four million individuals in the US and is the most common cause of dementia in North America and Europe. Genetic factors play an important role in the pathogenesis of AD...
  25. THE ROLE OF A-BETA SPECIES IN VASCULAR SMOOTH MUSCLE CELL AND CEREBRAL ARTERIOLE
    Gregory J Zipfel; Fiscal Year: 2013
    ..Alzheimer's Disease (AD) is the leading cause of dementia;yet no therapy exists to slow or stop its progression...
  26. Cerebral Malaria: Mechanisms of disease and neurological salvage
    Mahalia S Desruisseaux; Fiscal Year: 2013
    ..Dysregulation of tau protein which is important in the dementia of Alzheimer's disease and abnormalities in the regulation of Akt- one of the signaling pathways that is ..
  27. Endothelial-reactive antibodies: a diagnostic test for Susac's syndrome
    WILLIAM JAMES WALDMAN; Fiscal Year: 2011
    ..visual defects, hearing loss, and a variety of brain dysfunctions (headaches, memory loss, personality changes, dementia). In the absence of a diagnostic test the disease is often misdiagnosed...
  28. Regulation of HIV-1 by Rad51 in CNS cells
    Kamel Khalili; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: AIDS dementia complex, minor motor cognitive disorders and peripheral neuropathies remain significant in HIV-1 associated ..
  29. ALS therapies and genomics for mutant TDP-43 and TLS/FUS
    Don W Cleveland; Fiscal Year: 2010
    ..vast majority of ALS sporadic patients and in several other neurodegenerative diseases including Frontal Temporal Dementia (FTD), errors in TDP-43 may be central to understanding disease mechanism not just in ALS by also other ..
  30. Epigenetic mechanisms of TDP43-mediated neurodegeneration
    Amit Berson; Fiscal Year: 2013
    ..We began our analysis with an established model of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS)...
  31. Core Center for BioBehavioral Sciences of Communication Disorders
    Mabel L Rice; Fiscal Year: 2013
    ..in elder adults, clinical trials of intervention to chang the communication style of care-givers of patients with dementia, infant visual neuroperceptual development as a predictor of later cognitive and language development, clinical ..
  32. International Conf on Alzheimer Disease and Related Disorders in the Middle East
    Changiz Geula; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Alzheimer's disease is a major health problem and the leading cause of dementia in the Americas and Europe. There has been little work done on dementia in the Middle East...
  33. Mutational Cloning in Familial Dementia and Alzheimers Disease
    Wendy H Raskind; Fiscal Year: 2010
    ..goal of this proposal is to identify novel genes that are responsible for mendelian, highly penetrant familial dementia (FD) of either Alzheimer's disease (AD) or frontotemporal dementia (FTD) subtype...
  34. MOLECULAR MIMICRY IN IMMUNE MEDIATED NEUROLOGIC DISEASE
    Michael Levin; Fiscal Year: 2013
    ..been recently implicated in the pathogenesis of neurodegenerative disease like amyotropic lateral sclerosis and dementia. However, there are little data on the role that RBPs play in neurodegeneration in immune-mediated diseases like ..
  35. Extracellular Matrix Remodeling During Aging
    JANE M SOTTILE; Fiscal Year: 2010
    ..Aging is also associated with a number of diseases including arthritis, dementia, heart failure, hypertension, and atherosclerosis...
  36. HIV/NeuroAIDS Patient Derived Induced Pluripotent Stem (iPS) Cells
    Rodney J Nash; Fiscal Year: 2012
    ..The medical conditions include sensory neuropathy, myelopathy, HIV dementia, and cognitive/motor disorder abnormalities...
  37. Mechanisms Underlying Social Cooperative Behavior
    LUKE JOSEPH CHANG; Fiscal Year: 2010
    ..of neuropsychiatric disorders including psychopathy, depression, traumatic brain injury, and fronto-temporal dementia. My long-term goal is to pursue an academic career as a clinical neuroscientist, in which I will use neuroimaging ..
  38. VITAMIN D DEFICIENCY, INSULIN RESISTANCE AND CARDIOVASCULAR DISEASE
    Carlos Bernal-Mizrachi; Fiscal Year: 2013
    ..the new vitamin D analogs on common complications affecting diabetic patients, such as cerebrovascular disease, dementia, diabetic nephropathy, and retinopathy...
  39. Longitudinal Study of Lipids and APOE in the Development of AD and AD Pathology
    Michelle M Mielke; Fiscal Year: 2013
    ..follow-up, and their interaction with ApoE to predict: 1) decline in tests of memory;2) incident MCI, all-cause dementia, and AD;3) change in serial MRI measures of brain atrophy and white matter lesion burden over 10 years;and 4) ..
  40. Kynurenic Acid Synthesis in Mouse Brain
    Jianyong Li; Fiscal Year: 2010
    ..provided by applicant): It is currently estimated that in 2050, the cost of treating the aging population for dementia caused by various neurodegenerative diseases will consume the entire gross national product of the industrialized ..
  41. Novel CNS Target for Sleep-Wake and Psychiatric Disorders
    SCOTT MCNEAR THACHER; Fiscal Year: 2010
    ..sleep disorders (CRSDs) such as delayed sleep phase disorder (DSPD), jet lag, shift work sleep disorder, and dementia, where disruption of sleep-wake patterns is of major economic and clinical significance...
  42. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
    ..may be applied to various neurological disease with diminished CBF including Alzheimer's and vascular type dementia, vascular diseases such as vasospasm, amyloidosis, atherosclerosis, venous hypertension, and CSF hydrodynamic ..
  43. Reducing Care-Resistant Behaviors During Oral Hygiene in Persons with Dementia
    Rita A Jablonski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nursing home (NH) residents with dementia are often dependent on others for mouth care, yet will react with care-resistant behavior (CRB) when receiving assistance...
  44. Functional Assessment of the Locus for Atrial Fibrillation on Chromosome 4q25
    PATRICK THOMAS ELLINOR; Fiscal Year: 2010
    ..most common arrhythmia affecting over 2 million Americans, and is associated with an increased risk of stroke, dementia, heart failure and death...
  45. Glucocerebrosidase mutations in a mouse synucleinopathy model
    Robert L Nussbaum; Fiscal Year: 2011
    ..neurons causes the characteristic parkinsonian movement disorder while non-motor disabilities including dementia, depression, gastrointestinal dysfunction, and autonomic instability arise from neurodegeneration in other parts ..
  46. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2012
    ..In addition to the characteristic dementia seen in AD, many patients exhibit a range of non-cognitive symptoms that include depression, aggression, ..
  47. Analysis and Therapy of Age-Dependent Proteostasis Failure in Neurodegeneration
    ROBERT JOSEPH SHMOOKLER REIS; Fiscal Year: 2013
    ..by the regions affected, but it is becoming increasingly evident that the basic processes underlying Alzheimer dementia are remarkably similar to those leading to Parkinson's and Huntington's diseases, and Amyotrophic ..
  48. Small Molecule Probes for TAR DNA Binding Protein 43_TDP-43
    Allen B Reitz; Fiscal Year: 2012
    ..Amyotrophic lateral sclerosis (ALS, also motor neuron or Lou Gehrig's disease) and frontotemporal lobar dementia (FTLD) are debilitating neurodegenerative disorders that are now linked to TAR DNA-binding protein-43 (TDP-43)...
  49. Protective Effects of Cannabinoids in HIV Neuropathogenesis
    ROBERT BRYAN ROCK; Fiscal Year: 2012
    ..Project Narrative Despite the therapeutic impact of anti-retroviral therapy (ART), HIV-1-associated dementia (HAD) remains a serious threat to AIDS patients, and there currently remains no specific therapy for the ..
  50. Clinical and Molecular Biology of Acute and Chronic Traumatic Encephalopathies
    JAMES WAVELL AIKEN; Fiscal Year: 2011
    ..overlap between CTE and major neurodegenerative diseases, such as Alzheimer's disease (AD), frontotemporal dementia, and amyotrophic lateral sclerosis...
  51. Environmental Determinants of Cognitive Aging in the WHI Memory Study
    Jiu Chiuan Chen; Fiscal Year: 2013
    ..to better understand the environmental influence on brain aging and subsequent risk of cognitive impairment and dementia. Specifically, we will investigate later-life exposure to ambient air pollutants as novel environmental ..
  52. Neuron-Targeted Caveolin-1 as a Therapy for Age-Related Neurodegeneration
    Brian P Head; Fiscal Year: 2013
    ..Age alone increases the risk of stroke and the prevalence of AD and other forms of dementia. Learning, memory and the development of neurons are dependent upon synapses...
  53. Outcomes and Predictors in Mild Cognitive Impairment
    Mary Ganguli; Fiscal Year: 2012
    ..Broadly, the Research Plan aims to refine the current MCIcriteria based on predictive validity for dementia, using data from a new, ongoing, representative cohort study that was begun during the current K24 award period...
  54. Anti-Aging Mitochondrial Protein Therapy for Alzheimer?s Disease and Sarcopenia
    JAMES PEPPER BENNETT; Fiscal Year: 2010
    ..of motor and cognitive function in aging finds an extreme manifestation in the form of sarcopenia and senile dementia, most commonly of the Alzheimer's type. Both are associated with mitochondrial dysfunction...
  55. Predicting Cognitive Decline in Adults with Down Syndrome
    Ira T Lott; Fiscal Year: 2013
    ..decline in adults with Down syndrome and to ultimately provide a platform for early intervention to prevent the dementia associated with Alzheimer disease...
  56. The Impact of Oxidative Stress on HIV-induced Lung Disease
    Jesse Roman; Fiscal Year: 2013
    ..the expression and signaling of nAChRs expressed in brain, and this mechanism has been implicated in HIV-related dementia. We hypothesize that patients with HIV infection have oxidation of the Eh Cys/CySS which, together with gp120, ..
  57. Manganese Enhanced Multi-MRI for Murine HIV-1 Associated Neurocognitive Disorders
    Yutong Liu; Fiscal Year: 2013
    ..These range from mild motor/cognitive deficits to overt dementia (HIV-1 associated dementia, HAD)...
  58. Fine-Tuning the Notch Signaling Pathway via O-Glucosylation
    Hamed Jafar-Nejad; Fiscal Year: 2013
    ..Also, aberrant Notch signaling is involved in a variety of human diseases including cerebrovascular dementia, cancer and developmental disorders affecting liver, heart, skeleton, eye, and kidney...
  59. Chronic imaging of cellular dynamics after cortical microhemorrhage
    Chris B Schaffer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Brain microhemorrhages have been linked to cognitive decline and increased dementia risk, but the mechanisms by which small bleeds affect the function of neural cells remains unclear, in part due to a ..
  60. Preclinical Development of a Novel and Effective Treatment for Cough
    Blake M Paterson; Fiscal Year: 2011
    ..cough gating mechanisms have led to the observation that memantine (MMT), a registered drug for the treatment of dementia, is a profound antitussive in animal models...
  61. Human Stem Cell Model of Niemann Pick Type C
    Lawrence S Goldstein; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Niemann Pick Type C (NPC1) is a rare but lethal pediatric dementia caused by a mutation in NPC1, a housekeeping protein residing in the late endosomal compartment with a putative role in cholesterol ..
  62. Small Animal Model of HIV Neuropathogenesis in the HAART Era
    Pietro P Sanna; Fiscal Year: 2012
    ..While the incidence of severe HIV-associated dementia (HAD) has decreased since the introduction of HAART, the prevalence of milder and chronic forms of HIV central ..
  63. Measuring Altered Social Behavior in Neurodegenerative Disease
    Katherine P Rankin; Fiscal Year: 2013
    ..with a cohort of 325 patients (50 Probable Alzheimer's, 50 Possible Alzheimer's, 50 frontotemporal dementia, 50 cerebrovascular disease, 25 semantic dementia, 25 progressive nonfluent aphasia, 25 dementia with Lewy-bodies,..
  64. Dissecting the Role of HIV-1 Tat &Chemokine Axis in Subtype-Specificity of HAD
    Vinayaka R Prasad; Fiscal Year: 2012
    HIV-associated dementia (HAD) affects a significant number of HIV-infected individuals. A lower incidence/occurrence of HAD has been reported in populations with subtype C HIV-1 infections...
  65. Pioglitazone & Exercise Effects on Older Aldults with MCI and Metabolic Syndrome
    Robert S Schwartz; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Alzheimer's Disease (AD), and other forms of dementia, are devastating disorders with impressive untoward effects on patients, caregivers, our healthcare system and society as a whole...
  66. Cellular and molecular mechanisms of gp120 neurotoxicity
    Italo Mocchetti; Fiscal Year: 2012
    ..by applicant): Axonal injury is seen in subjects with Human Immunodeficiency Virus type 1 (HIV) associated dementia (HAD)...
  67. Fifth International Conference on Alzheimer's Disease in the ME
    Changiz Geula; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Alzheimer's disease is a major health problem and the leading cause of dementia in the Americas and Europe. There has been little work done on dementia in the Middle East...
  68. Glucocerebrosidase mutations in a mouse synucleinopathy model
    Robert L Nussbaum; Fiscal Year: 2010
    ..neurons causes the characteristic parkinsonian movement disorder while non-motor disabilities including dementia, depression, gastrointestinal dysfunction, and autonomic instability arise from neurodegeneration in other parts ..
  69. MENTAL ILLNESS IN THE ELDERLY--DIAGNOSTIC TESTING
    Andrew Leuchter; Fiscal Year: 1999
    ..In addition, we propose new initiatives to identify physiologic indicators of prognosis in dementia and depression, and to develop physiologic predictors of antidepressant treatment response...
  70. A Measurement-to-Management Tool to Improve Dementia Care
    TONY XUYEN MA; Fiscal Year: 2010
    ..is to develop a useful, practical, valid, and reliable tool to improve the quality of life (QOL) of people in dementia care settings...
  71. Comparative Effectiveness of Dementia Care Strategies in Underserved Communities
    BARBARA G contact VICKREY; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): While dementia carries profound implications for human suffering and economic burdens among more than 5 million people in the US and their caregivers, these implications are magnified in low-income ..
  72. Dementia and Disability in Thai Elderly
    Jeffrey Cummings; Fiscal Year: 2005
    DESCRIPTION (provided by applicant) Dementia is becoming increasingly common in underdeveloped societies...
  73. DETECTION OF EARLY DEMENTIA IN ADULTS WITH DOWN SYNDROME
    KAREN BRUGGE; Fiscal Year: 1999
    ..adults may be due to the lack of established sensitive neuropsychological measures in detecting early stages of dementia in DS...
  74. Cognitive Decline and Dementia: Life Experiences and the Brain Histone Epigenome
    David A Bennett; Fiscal Year: 2010
    ..the role of the brain histone epigenome in modulating the effect of life experiences on cognitive decline and dementia. In prior work, we found that while cognitive decline in old age often results from one or more of three common ..
  75. EPIDEMIOLOGY OF DEMENTIA IN OLDER JAPANESE AMERICANS
    Eric Larson; Fiscal Year: 2000
    Existing studies suggest that, while the overall prevalence rates of dementia in Japan and the U.S. are similar, the relative prevalence of Alzheimer's disease (AD) to vascular dementia (VaD) is much greater in the U.S...
  76. Antipsychotics and Mortality in Older Patients
    HELEN KALES; Fiscal Year: 2009
    ..indicate that atypical antipsychotic medications are associated with increased mortality among patients with dementia. Moreover, our group has recently demonstrated that both atypical and conventional antipsychotic medications are ..
  77. Chinese Dementia Care Research Center
    Sue Levkoff; Fiscal Year: 2009
    ..85% prevalence of Alzheimer's disease among individuals aged 65 and over, and a 1.1% prevalence of Vascular Dementia;thus, China is not a low risk nation for dementia...
  78. 18F-AV-133, A Novel Radiopharmaceutical for Differential Diagnosis of Dementia
    Franz Hefti; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Dementia, with its most prevalent subforms Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and vascular dementia, is a very substantial medical and societal problem...
  79. WEB-BASED DEMENTIA CARE TRAINING FOR PROFESSIONALS
    PENELOPE LANTZ; Fiscal Year: 2007
    ..this project is to develop, evaluate, and disseminate Web-based, low-literacy, low-cost, accredited training on dementia care to supervised nursing personnel...
  80. Life Is A Stage: Dementia Care and the Dramatic Arts
    John Zeisel; Fiscal Year: 2010
    ..exists for development of works of drama that can be performed in facilities providing care for persons with dementia, and which can involve such residents interactively...
  81. Anxiety Among Older Adults with Dementia in ALFs
    Marianne Smith; Fiscal Year: 2006
    The purpose of this study is to characterize anxiety symptoms among older adults with dementia who are living in assisted living facilities (ALFs)...
  82. Effects of Ethnicity/Race on Family Caregiving to Those*
    JORDAN KOSBERG; Fiscal Year: 2003
    ..The aim of our 2-year pilot research project is to increase knowledge on the experiences of family caregivers of dementia patients who live in rural communities...
  83. EPIDEMIOLOGY OF DEMENTIA IN AGED NURSING HOME ADMISSIONS
    Jay Magaziner; Fiscal Year: 2005
    DESCRIPTION: The long-term care of older persons with dementia is a major concern of providers and policymakers...
  84. 3-D Organotypic Model of HIV-infectable Tissue for AIDS-associated dementia
    CHERYL NICKERSON; Fiscal Year: 2009
    HIV-1 encephalitis (HIVE), is the common pathological correlate of HIV-associated dementia (HAD)...
  85. Effectiveness of Feeding Tubes Among Person with Advanced Cognitive Impairment
    Joan M Teno; Fiscal Year: 2010
    ..Advanced dementia is a common life-defining illness with a disease trajectory of eating problems, weight loss, and recurrent ..
  86. Amyloid Imaging, VMCI, and Analysis for ADNI
    Michael W Weiner; Fiscal Year: 2010
    ..determine the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the early (pre-dementia) stages of Alzheimer's disease (AD)...
  87. Feeding in Elderly Late-Stage Dementia: The FIELD Trial
    Elaine J Amella; Fiscal Year: 2010
    Feeding among persons with late-stage dementia is controversial as this vulnerable group lacks the cognitive capacity to state their preference...