post traumatic stress disorders

Summary

Summary: A class of traumatic stress disorders with symptoms that last more than one month. There are various forms of post-traumatic stress disorder, depending on the time of onset and the duration of these stress symptoms. In the acute form, the duration of the symptoms is between 1 to 3 months. In the chronic form, symptoms last more than 3 months. With delayed onset, symptoms develop more than 6 months after the traumatic event.

Top Publications

  1. ncbi Enhanced perceptual priming for neutral stimuli occurring in a traumatic context: two experimental investigations
    T Michael
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK
    Behav Res Ther 45:341-58. 2007
  2. ncbi Physical and mental health of Afghan, Iranian and Somali asylum seekers and refugees living in the Netherlands
    Annette A M Gerritsen
    Dept of Medical Psychology, VU University Medical Centre, Van der Boechorststraat 7, Room D433, 1081 BT, Amsterdam, The Netherlands
    Soc Psychiatry Psychiatr Epidemiol 41:18-26. 2006
  3. ncbi Mental health problems, use of mental health services, and attrition from military service after returning from deployment to Iraq or Afghanistan
    Charles W Hoge
    Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Washington, DC, USA
    JAMA 295:1023-32. 2006
  4. ncbi Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study
    Laura D Kubzansky
    Harvard School of Public Health, Veterans Affairs Normative Aging Study, Veterans Affairs Boston Health Care System, Boston University School of Medicine, 677 Huntington Avenue, Boston, MA 02115, USA
    Arch Gen Psychiatry 64:109-16. 2007
  5. ncbi School-based mental health intervention for children affected by political violence in Indonesia: a cluster randomized trial
    Wietse A Tol
    HealthNet TPO, Department of Public Health and Research, Tolstraat 127, 1074 VJ, Amsterdam, The Netherlands
    JAMA 300:655-62. 2008
  6. ncbi A cognitive model of posttraumatic stress disorder
    A Ehlers
    Department of Psychiatry, University of Oxford, Warneford Hospital, UK
    Behav Res Ther 38:319-45. 2000
  7. ncbi Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults
    C R Brewin
    Subdepartment of Clinical Health Psychology, University College London, England
    J Consult Clin Psychol 68:748-66. 2000
  8. ncbi Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis
    Emily J Ozer
    Department of Psychiatry, University of California, San Francisco 94143 0984, USA
    Psychol Bull 129:52-73. 2003
  9. ncbi Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma
    N Breslau
    Department of Psychiatry, Henry Ford Health System, Detroit, Mich 48202 3450, USA
    Arch Gen Psychiatry 55:626-32. 1998
  10. ncbi Combat duty in Iraq and Afghanistan, mental health problems, and barriers to care
    Charles W Hoge
    Department of Psychiatry and Behavioral Sciences, Walter Reed Army Institute of Research, U S Army Medical Research and Materiel Command, Silver Spring, MD 20910, USA
    N Engl J Med 351:13-22. 2004

Research Grants

Detail Information

Publications374 found, 100 shown here

  1. ncbi Enhanced perceptual priming for neutral stimuli occurring in a traumatic context: two experimental investigations
    T Michael
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK
    Behav Res Ther 45:341-58. 2007
    ..The results support the role of perceptual priming in intrusions after traumatic events...
  2. ncbi Physical and mental health of Afghan, Iranian and Somali asylum seekers and refugees living in the Netherlands
    Annette A M Gerritsen
    Dept of Medical Psychology, VU University Medical Centre, Van der Boechorststraat 7, Room D433, 1081 BT, Amsterdam, The Netherlands
    Soc Psychiatry Psychiatr Epidemiol 41:18-26. 2006
    ..Although asylum seekers have been coming to the Netherlands since the 1980s, very few epidemiological studies have focused on this group of inhabitants or on the refugees who have resettled in this country...
  3. ncbi Mental health problems, use of mental health services, and attrition from military service after returning from deployment to Iraq or Afghanistan
    Charles W Hoge
    Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Washington, DC, USA
    JAMA 295:1023-32. 2006
    ..To date, no systematic analysis of this program has been conducted, and studies have not assessed the impact of these deployments on mental health care utilization after deployment...
  4. ncbi Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study
    Laura D Kubzansky
    Harvard School of Public Health, Veterans Affairs Normative Aging Study, Veterans Affairs Boston Health Care System, Boston University School of Medicine, 677 Huntington Avenue, Boston, MA 02115, USA
    Arch Gen Psychiatry 64:109-16. 2007
    ..To our knowledge, no prospective studies to date have evaluated whether PTSD is associated with increased risk of CHD...
  5. ncbi School-based mental health intervention for children affected by political violence in Indonesia: a cluster randomized trial
    Wietse A Tol
    HealthNet TPO, Department of Public Health and Research, Tolstraat 127, 1074 VJ, Amsterdam, The Netherlands
    JAMA 300:655-62. 2008
    ..Childhood mental health problems are difficult to address in situations of ongoing poverty and political instability...
  6. ncbi A cognitive model of posttraumatic stress disorder
    A Ehlers
    Department of Psychiatry, University of Oxford, Warneford Hospital, UK
    Behav Res Ther 38:319-45. 2000
    ..Recent studies have provided preliminary support for several aspects of the model...
  7. ncbi Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults
    C R Brewin
    Subdepartment of Clinical Health Psychology, University College London, England
    J Consult Clin Psychol 68:748-66. 2000
    ....
  8. ncbi Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis
    Emily J Ozer
    Department of Psychiatry, University of California, San Francisco 94143 0984, USA
    Psychol Bull 129:52-73. 2003
    ..17) and peritraumatic dissociation the largest (weighted r = .35). The results suggest that peritraumatic psychological processes, not prior characteristics, are the strongest predictors of PTSD...
  9. ncbi Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma
    N Breslau
    Department of Psychiatry, Henry Ford Health System, Detroit, Mich 48202 3450, USA
    Arch Gen Psychiatry 55:626-32. 1998
    ..The study estimates the relative importance of specific types of traumas experienced in the community in terms of their prevalence and risk of leading to posttraumatic stress disorder (PTSD)...
  10. ncbi Combat duty in Iraq and Afghanistan, mental health problems, and barriers to care
    Charles W Hoge
    Department of Psychiatry and Behavioral Sciences, Walter Reed Army Institute of Research, U S Army Medical Research and Materiel Command, Silver Spring, MD 20910, USA
    N Engl J Med 351:13-22. 2004
    ....
  11. ncbi The construction of autobiographical memories in the self-memory system
    M A Conway
    Department of Experimental Psychology, University of Bristol, England
    Psychol Rev 107:261-88. 2000
    ..It is shown how this model can be used to draw together a wide range of diverse data from cognitive, social, developmental, personality, clinical, and neuropsychological autobiographical memory research...
  12. ncbi Longitudinal assessment of mental health problems among active and reserve component soldiers returning from the Iraq war
    Charles S Milliken
    Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, US Army Medical Research and Materiel Command, Silver Spring, Maryland 20910, USA
    JAMA 298:2141-8. 2007
    ..A previous article focusing only on the initial screening is likely to have underestimated the mental health burden...
  13. ncbi Sex differences in trauma and posttraumatic stress disorder: a quantitative review of 25 years of research
    David F Tolin
    Anxiety Disorders Center, The Institute of Living, Hartford, CT 06106, USA
    Psychol Bull 132:959-92. 2006
    ..Thus, sex differences in risk of exposure to particular types of PTE can only partially account for the differential PTSD risk in male and female participants...
  14. ncbi A dual representation theory of posttraumatic stress disorder
    C R Brewin
    Department of Psychology, University of London, Egham, Surrey, England
    Psychol Rev 103:670-86. 1996
    ....
  15. ncbi Intrusive re-experiencing in post-traumatic stress disorder: phenomenology, theory, and therapy
    Anke Ehlers
    Department of Psychology, Institute of Psychiatry, London, UK
    Memory 12:403-15. 2004
    ..into the worst moments of the trauma memory, and to train patients to discriminate between the stimuli that were present during the trauma ("then") and the innocuous triggers of re-experiencing symptoms ("now")...
  16. ncbi If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans
    Gregory E Miller
    Department of Psychology, University of British Columbia UBC, Vancouver, BC, Canada
    Psychol Bull 133:25-45. 2007
    ..Finally, HPA activity is shaped by a person's response to the situation; it increases with subjective distress but is lower in persons with posttraumatic stress disorder...
  17. ncbi Posttraumatic stress disorder: the burden to the individual and to society
    R C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Mass 02115, USA
    J Clin Psychiatry 61:4-12; discussion 13-4. 2000
    ..Little is known about the total population prevalence and societal costs of posttraumatic stress disorder (PTSD); this report reviews relevant literature on these topics...
  18. ncbi Pilot study of secondary prevention of posttraumatic stress disorder with propranolol
    Roger K Pitman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 51:189-92. 2002
    ..This pilot study addressed this hypothesis...
  19. ncbi Development and preliminary validation of a brief broad-spectrum measure of trauma exposure: the Traumatic Life Events Questionnaire
    E S Kubany
    National Center for PTSD, Pacific Island Division, Department of Veterans Affairs, Honolulu, Hawai i 96813, USA
    Psychol Assess 12:210-24. 2000
    ..In a study comparing questionnaire and structured-interview inquiries of trauma history, the 2 formats yielded similar rates of disclosure. Preliminary data on positive predictive power are also presented...
  20. pmc Psychological trauma and evidence for enhanced vulnerability for posttraumatic stress disorder through previous trauma among West Nile refugees
    Frank Neuner
    Department of Psychology, University of Konstanz and Center for Psychiatry Reichenau, D 78457 Konstanz, Germany
    BMC Psychiatry 4:34. 2004
    ..High exposure to traumatic experiences has been particularly prominent in the Ugandan and Sudanese of the West Nile Region, representing an indication of the psychological strain posed by years of armed conflict...
  21. ncbi Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation
    R A Lanius
    Department of Psychiatry, University of Western Ontario, London, Canada
    Am J Psychiatry 158:1920-2. 2001
    ..The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD...
  22. ncbi 60,000 disaster victims speak: Part I. An empirical review of the empirical literature, 1981-2001
    Fran H Norris
    Georgia State University, Atlanta, GA, USA
    Psychiatry 65:207-39. 2002
    ..Among youth, family factors were primary. Implications of the research for clinical practice and community intervention are discussed in a companion article (Norris, Friedman, and Watson, this volume)...
  23. ncbi Longitudinal study of earthquake-related PTSD in a randomly selected community sample in north China
    X Wang
    Institute of Mental Health, Beijing Medical University, China
    Am J Psychiatry 157:1260-6. 2000
    ..The effects of diagnostic criteria on the frequency of detected PTSD were also examined...
  24. ncbi Hippocampal function in posttraumatic stress disorder
    Lisa M Shin
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    Hippocampus 14:292-300. 2004
    ....
  25. ncbi An fMRI study of anterior cingulate function in posttraumatic stress disorder
    L M Shin
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Biol Psychiatry 50:932-42. 2001
    ..We speculate that diminished recruitment of this region in PTSD may, in part, mediate symptoms such as distress and arousal upon exposure to reminders of trauma...
  26. ncbi Psychological treatments for chronic post-traumatic stress disorder. Systematic review and meta-analysis
    Jonathan I Bisson
    Department of Psychological Medicine, Cardiff University, and University Hospital of Wales, UK
    Br J Psychiatry 190:97-104. 2007
    ..The relative efficacy of different psychological treatments for chronic post-traumatic stress disorder (PTSD) is unclear...
  27. ncbi A multidimensional meta-analysis of psychotherapy for PTSD
    Rebekah Bradley
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Am J Psychiatry 162:214-27. 2005
    ..The authors present a multidimensional meta-analysis of studies published between 1980 and 2003 on psychotherapy for PTSD...
  28. ncbi Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD
    Lisa M Shin
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Arch Gen Psychiatry 61:168-76. 2004
    ..However, the functional relationship between these brain regions in PTSD has not been directly examined...
  29. ncbi Clinician-administered PTSD scale: a review of the first ten years of research
    F W Weathers
    Department of Psychology, 226 Thach Hall, Auburn University, Auburn, AL 36849 5214, USA
    Depress Anxiety 13:132-56. 2001
    ..Finally, we address several concerns about the CAPS and offer recommendations for optimizing the CAPS for various clinical research applications...
  30. ncbi Interapy: a controlled randomized trial of the standardized treatment of posttraumatic stress through the internet
    Alfred Lange
    Department of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands
    J Consult Clin Psychol 71:901-9. 2003
    ..The effect sizes were large. On most subscales, more than 50% of the treated participants showed reliable change and clinically significant improvement, with the highest percentages being found for depression and avoidance...
  31. ncbi Sensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in ARDS patients after intensive care treatment
    C Stoll
    Dept of Anaesthesiology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Intensive Care Med 25:697-704. 1999
    ..In order to simplify the rapid and early detection of PTSD in such patients, we modified an existing questionnaire for diagnosis of PTSD and validated the instrument in a cohort of ARDS patients after long-term ICU therapy...
  32. ncbi Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies
    Joseph A Boscarino
    Division of Health and Science Policy, Room 552, The New York Academy of Medicine, 1216 Fifth Avenue, New York, NY 10029 5293, USA
    Ann N Y Acad Sci 1032:141-53. 2004
    ..The latter clinical evidence confirms the presence of biological markers consistent with a broad range of inflammatory disorders, including both cardiovascular and autoimmune diseases...
  33. ncbi Hypocortisolism and increased glucocorticoid sensitivity of pro-Inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder
    Nicolas Rohleder
    Department of Psychology, Institute of Experimental Psychology II, University of Dusseldorf, Dusseldorf, Germany
    Biol Psychiatry 55:745-51. 2004
    ..Alterations include various responses to HPA axis stimulation, different basal hormone levels, and changes in glucocorticoid receptor (GR) numbers on lymphocytes. The functional significance of these latter changes remains elusive...
  34. ncbi Inducing and modulating intrusive emotional memories: a review of the trauma film paradigm
    Emily A Holmes
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Acta Psychol (Amst) 127:553-66. 2008
    ..It is hoped that further use of this paradigm may lead to prophylactic training for at risk groups and an improved understanding of intrusions across psychopathologies...
  35. ncbi Post-traumatic stress disorder
    Rachel Yehuda
    Division of Traumatic Stress Studies and Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs Medical Center, New York 10468, USA
    N Engl J Med 346:108-14. 2002
  36. ncbi Dissociation and post-traumatic stress disorder: two prospective studies of road traffic accident survivors
    James Murray
    Department of Psychology, University of Surrey, Guildford, UK
    Br J Psychiatry 180:363-8. 2002
    ..Dissociative symptoms during trauma predict post-traumatic stress disorder (PTSD), but they are often transient. It is controversial whether they predict chronic PTSD over and above what can be predicted from other post-trauma symptoms...
  37. ncbi MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Clinical Neuroscience Research Unit, Emory University School of Medicine, 1256 Briarcliff Road, Atlanta, GA 30306, USA
    Am J Psychiatry 160:924-32. 2003
    ..The purpose of this study was to measure both hippocampal structure and function in women with and without early childhood sexual abuse and the diagnosis of posttraumatic stress disorder (PTSD)...
  38. ncbi A randomized controlled trial of cognitive therapy, a self-help booklet, and repeated assessments as early interventions for posttraumatic stress disorder
    Anke Ehlers
    Department of Psychology, Institute of Psychiatry, London, UK
    Arch Gen Psychiatry 60:1024-32. 2003
    ..Similarly, there is a lack of clarity about the best way of identifying people who are unlikely to recover from early posttraumatic symptoms without intervention...
  39. ncbi Construct validation of the Dutch version of the impact of event scale
    Eleonore van der Ploeg
    Department of Clinical Psychology, Utrecht University, Utrecht, Netherlands
    Psychol Assess 16:16-26. 2004
    ..The construct validity was assessed by using confirmatory factor analyses. Outcomes revealed a robust structure over the various samples, generally supporting the composition of the original IES...
  40. pmc Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma
    Mark W Gilbertson
    Research Service, Veterans Administration Medical Center, 718 Smyth Road, Manchester, New Hampshire 03104, USA
    Nat Neurosci 5:1242-7. 2002
    ..Furthermore, severe PTSD twin pairs-both the trauma-exposed and unexposed members-had significantly smaller hippocampi than non-PTSD pairs...
  41. ncbi Trauma exposure and post-traumatic stress disorder in the general population
    O Frans
    Department of Psychology, Uppsala University, Uppsala, Sweden
    Acta Psychiatr Scand 111:291-9. 2005
    ..To examine the lifetime prevalence of trauma experiences and post-traumatic stress disorder (PTSD)...
  42. pmc Genetics of post-traumatic stress disorder: informing clinical conceptualizations and promoting future research
    Nicole R Nugent
    Brown Medical School and Bradley Hasbro Children s Research Center, USA
    Am J Med Genet C Semin Med Genet 148:127-32. 2008
    ..Finally, we summarize findings from molecular genetic studies, which have the potential to inform our understanding of underlying biological mechanisms for the development of PTSD...
  43. ncbi Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and future
    Scott L Rauch
    Psychiatric Neuroscience Division, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Biol Psychiatry 60:376-82. 2006
    ..The recent development of such imaging probes now sets the stage for directly testing hypotheses regarding the neural substrates of fear conditioning and extinction abnormalities in PTSD...
  44. ncbi Posttraumatic stress disorder: a state-of-the-science review
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322 4990, USA
    J Psychiatr Res 40:1-21. 2006
    ....
  45. ncbi Health-related quality of life and post-traumatic stress disorder in patients after cardiac surgery and intensive care treatment
    C Stoll
    Departments of Anaesthesiology, Cardiac Surgery, and Psychiatry, Ludwig Maximilians University, Munich, Germany
    J Thorac Cardiovasc Surg 120:505-12. 2000
    ....
  46. ncbi Genetics of posttraumatic stress disorder: Review and recommendations for future studies
    Karestan C Koenen
    Department of Society, Human Development, and Health and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Trauma Stress 20:737-50. 2007
    ..Recommendations for future studies are presented with emphasis on study design and assessment issues particular to the field of trauma and PTSD. Clinical implications of PTSD genetic studies are discussed...
  47. pmc Post-conflict mental health needs: a cross-sectional survey of trauma, depression and associated factors in Juba, Southern Sudan
    Bayard Roberts
    Conflict and Health Programme, Health Policy Unit, Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
    BMC Psychiatry 9:7. 2009
    ....
  48. ncbi Psychometric properties of the Impact of Event Scale - Revised
    Mark Creamer
    Australian Centre for Posttraumatic Mental Health, Heidelberg, Victoria, Australia
    Behav Res Ther 41:1489-96. 2003
    ..The correlation between the IES-R and the PTSD Checklist was high (0.84) and a cutoff of 1.5 (equivalent to a total score of 33) was found to provide the best diagnostic accuracy...
  49. ncbi Daily stressors, war experiences, and mental health in Afghanistan
    Kenneth E Miller
    Boston Center for Refugee Health and Human Rights at Boston University, Boston, MA 02118, USA
    Transcult Psychiatry 45:611-38. 2008
    ..The study's implications for research and intervention in conflict and post-conflict settings are considered...
  50. pmc PTSD onset and course following the World Trade Center disaster: findings and implications for future research
    Joseph A Boscarino
    Center for Health Research, Geisinger Clinic, Danville, PA, 17822 4400, USA
    Soc Psychiatry Psychiatr Epidemiol 44:887-98. 2009
    ..We sought to identify common risk factors associated with posttraumatic stress disorder (PTSD) onset and course, including delayed, persistent, and remitted PTSD following a major traumatic exposure...
  51. ncbi Full and partial PTSD among earthquake survivors in rural Taiwan
    Te Jen Lai
    Institute of Medicine, Chung Shan Medical University and Department of Psychiatry, Chung Shan Medical Hospital, Taichung, Taiwan
    J Psychiatr Res 38:313-22. 2004
    ..In conclusion, PTSD and PTSS are commonly observed following earthquake exposure and are associated with similarly high levels of psychosocial impairment...
  52. ncbi Post-traumatic stress disorder: findings from the Australian National Survey of Mental Health and Well-being
    M Creamer
    National Centre for PTSD, Mental Health Research Institute, University of Melbourne, Vic, Australia
    Psychol Med 31:1237-47. 2001
    ..Future research is needed to investigate rates among other populations outside the North American continent...
  53. ncbi A comparison of narrative exposure therapy, supportive counseling, and psychoeducation for treating posttraumatic stress disorder in an african refugee settlement
    Frank Neuner
    Department of Clinical Psychology, University of Konstanz, Konstanz, Germany
    J Consult Clin Psychol 72:579-87. 2004
    ..These results indicate that NET is a promising approach for the treatment of PTSD for refugees living in unsafe conditions...
  54. ncbi Incidence and prediction of posttraumatic stress disorder symptoms in severely injured accident victims
    U Schnyder
    Psychiatric Department, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
    Am J Psychiatry 158:594-9. 2001
    ..This study was designed to assess the incidence of posttraumatic stress disorder (PTSD) in severely injured accident victims and to predict the presence of PTSD symptoms at a 12-month follow-up...
  55. ncbi Initial urinary epinephrine and cortisol levels predict acute PTSD symptoms in child trauma victims
    Douglas L Delahanty
    Department of Psychology, Kent State University, 118 Kent Hall, Kent, OH 44242, USA
    Psychoneuroendocrinology 30:121-8. 2005
    ..The present study extended these findings by examining whether urinary hormone levels collected soon after a trauma were related to subsequent acute PTSD symptoms in child trauma victims...
  56. ncbi Potential role of the anterior cingulate cortex in PTSD: review and hypothesis
    M B Hamner
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, USA
    Depress Anxiety 9:1-14. 1999
    ..If confirmed in future research, cingulate dysfunction would have important theoretical and treatment implications...
  57. ncbi Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse
    C Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Psychiatry 158:575-81. 2001
    ..On subsequent stress exposure, women with a history of childhood abuse may hypersecrete CRF, resulting in down-regulation of adenohypophyseal CRF receptors and symptoms of depression and anxiety...
  58. ncbi A correlational test of the relationship between posttraumatic growth, religion, and cognitive processing
    L G Calhoun
    Department of Psychology, UNC Charlotte 28223, USA
    J Trauma Stress 13:521-7. 2000
    ..Present findings offer some confirmation of theoretical predictions, and also offer clear direction for further research on the relationships of religion, rumination, and posttraumatic growth...
  59. ncbi Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors
    R H Segman
    Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
    Mol Psychiatry 10:500-13, 425. 2005
    ..Replications in larger samples, as well as studies focusing on specific markers within the signatures discovered, are warranted to confirm and extend the diagnostic utility and pathogenetic implications of our results...
  60. ncbi Trauma and hallucinatory experience in psychosis
    Amy Hardy
    Institute of Psychiatry, Kings College London, London, United Kingdom
    J Nerv Ment Dis 193:501-7. 2005
    ..The traumas most likely to be associated with hallucinations were sexual abuse and bullying...
  61. ncbi Alterations in cerebral perfusion in posttraumatic stress disorder patients without re-exposure to accident-related stimuli
    Yong An Chung
    Department of Radiology, The Catholic University of Korea, Seoul, South Korea
    Clin Neurophysiol 117:637-42. 2006
    ..Functional neuroimaging studies have shown abnormalities of limbic regions in patients with posttraumatic stress disorder (PTSD) during symptom provocation and cognitive activation...
  62. ncbi CSF norepinephrine concentrations in posttraumatic stress disorder
    T D Geracioti
    Mental Health Service, Veterans Affairs Medical Center, 3200 Vine St, Cincinnati, OH 45220, USA
    Am J Psychiatry 158:1227-30. 2001
    ..The goal of this study was to determine serial CSF norepinephrine levels in patients with PTSD...
  63. pmc Brief report: Utility of a short screening scale for DSM-IV PTSD in primary care
    Rachel Kimerling
    VA Palo Alto Health Care System, Palo Alto, CA 94025, USA
    J Gen Intern Med 21:65-7. 2006
    ..To evaluate Breslau's 7-item screen for posttraumatic stress disorder (PTSD) for use in primary care...
  64. ncbi A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear
    Anja Siegmund
    Max Planck Institut fur Psychiatrie, AG Neuronale Plastizität, Kraepelinstr 2, D 80804 Munich, Germany
    J Psychiatr Res 41:848-60. 2007
    ....
  65. ncbi Epidemiology of trauma and posttraumatic stress disorder in Mexico
    Fran H Norris
    Department of Psychiatry, Dartmouth Medical School, Dartmouth College, White River Junction, VT, USA
    J Abnorm Psychol 112:646-56. 2003
    ..Of lifetime cases, 62% became chronic; only 42% received medical or professional care. The research demonstrates the importance of expanding the epidemiologic research base on trauma to include developing countries around the world...
  66. ncbi Structural and functional brain changes in posttraumatic stress disorder
    David J Nutt
    Psychopharmacology Unit, University of Bristol, Bristol, United Kingdom
    J Clin Psychiatry 65:11-7. 2004
    ..The findings of structural and functional neuroimaging studies of PTSD are reviewed as they relate to our current understanding of the pathophysiology of this disorder...
  67. ncbi Alcohol abuse in individuals exposed to trauma: a critical review
    S H Stewart
    Department of Psychology, Dalhousie University, Halifax Nova, Scotia, Canada
    Psychol Bull 120:83-112. 1996
    ..Finally, the author outlines novel methods for testing theoretical hypotheses and makes suggestions for methodological improvements in future research...
  68. ncbi Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study
    Murray B Stein
    Anxiety and Traumatic Stress Disorders Program, Department of Psychiatry 0985, University of California San Diego, La Jolla, CA 92093 0985, USA
    Am J Psychiatry 159:1675-81. 2002
    ..In this study the authors examined the heritability of trauma exposure and PTSD symptoms in male and female twin pairs of nonveteran volunteers...
  69. ncbi Early post-transplant medical compliance and mental health predict physical morbidity and mortality one to three years after heart transplantation
    M A Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine and Medical Center, Pennsylvania 15213, USA
    J Heart Lung Transplant 18:549-62. 1999
    ..We prospectively examined whether a full range of compliance behaviors and psychiatric outcomes during the first year post-transplant predicted subsequent mortality and physical morbidity through 3 years post-transplant...
  70. ncbi Reliability of reports of violent victimization and posttraumatic stress disorder among men and women with serious mental illness
    L A Goodman
    Counseling Psychology Program, School of Education, Boston College, MA 02467, USA
    J Trauma Stress 12:587-99. 1999
    ..The study also demonstrates the importance of using a variety of statistical methods to assess the reliability of self-reports of trauma history...
  71. ncbi Longitudinal course of posttraumatic stress disorder and posttraumatic stress disorder symptoms in a community sample of adolescents and young adults
    Axel Perkonigg
    Clinical Psychology and Epidemiology Department, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Am J Psychiatry 162:1320-7. 2005
    ..The authors examined determinants of remission and chronicity of PTSD and associations with other disorders in a prospective community sample...
  72. ncbi Short screening scale for DSM-IV posttraumatic stress disorder
    N Breslau
    Department of Psychiatry, Henry Ford Health System, Detroit, MI, USA
    Am J Psychiatry 156:908-11. 1999
    ..The authors' goal was to construct a short screening scale for DSM-IV posttraumatic stress disorder (PTSD)...
  73. ncbi Functional neuroimaging in post-traumatic stress disorder
    J Douglas Bremner
    Emory University, Atlanta, GA 30306, USA
    Expert Rev Neurother 7:393-405. 2007
    ..Future studies are required to assess the relationship between recovery from traumatic stress and changes in brain function...
  74. ncbi Toward an animal model of posttraumatic stress disorder
    Anja Siegmund
    Max Planck Institute of Psychiatry, Neuronal Plasticity Group, Kraepelinstr 2, D 80804 Munich, Germany
    Ann N Y Acad Sci 1071:324-34. 2006
    ....
  75. ncbi A systematic and conceptual review of posttraumatic stress in childhood cancer survivors and their parents
    Matt Bruce
    Subdepartment of Clinical Health Psychology, University College London, Gower Street, London, WC1E 6BT, UK
    Clin Psychol Rev 26:233-56. 2006
    ..Finally, a number of pertinent research areas are elucidated which are argued to warrant further investigation...
  76. ncbi Brief screening instrument for post-traumatic stress disorder
    Chris R Brewin
    Subdepartment of Clinical Health Psychology, University College London, UK
    Br J Psychiatry 181:158-62. 2002
    ..Brief screening instruments appear to be a viable way of detecting post-traumatic stress disorder (PTSD) but none has yet been adequately validated...
  77. ncbi Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model
    K Kohda
    Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neuroscience 148:22-33. 2007
    ..The preventive effects of a GR antagonist suggested that GR activation might play a critical role in producing the altered behavior and neuronal function of SPS rats...
  78. pmc Enhanced cortisol suppression following dexamethasone administration in domestic violence survivors
    Michael G Griffin
    University of Missouri St Louis, Center for Trauma Recovery, St Louis, MO 63121, USA
    Am J Psychiatry 162:1192-9. 2005
    ..The authors compared responses of female domestic violence survivors and a matched group of nontraumatized participants to a low-dose (0.5 mg) dexamethasone suppression test (DST)...
  79. pmc Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
    Psychol Med 35:791-806. 2005
    ..No studies have examined neural correlates of fear conditioning and extinction in patients with post-traumatic stress disorder (PTSD)...
  80. ncbi Memory for trauma-related information in Holocaust survivors with PTSD
    Julia A Golier
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychiatry Res 121:133-43. 2003
    ..This trauma-related facilitation of explicit memory, together with generally poorer explicit memory, may help to explain the bi-directional nature of the memory impairments in PTSD...
  81. ncbi Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis
    Marie Louise Meewisse
    Center for Psychological Trauma, Academic Medical Center de Meren, Department of Psychiatry, University of Amsterdam, Meibergdreef 5, Amsterdam, The Netherlands
    Br J Psychiatry 191:387-92. 2007
    ..Post-traumatic stress disorder (PTSD) has inconsistently been associated with lower levels of cortisol...
  82. ncbi Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder
    V G Carrion
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5719, USA
    Biol Psychiatry 50:943-51. 2001
    ..The implications of the findings and their consistency with previous research are discussed...
  83. ncbi Association of posttraumatic stress disorder with somatic symptoms, health care visits, and absenteeism among Iraq war veterans
    Charles W Hoge
    Department of Psychiatry and Behavioral Sciences, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    Am J Psychiatry 164:150-3. 2007
    ..The current Iraq war has posed a considerable PTSD risk, but the association with physical health has not been well studied...
  84. ncbi Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study
    Michael D De Bellis
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 52:1066-78. 2002
    ..Previous anatomical magnetic resonance imaging (MRI) brain studies have not controlled for socioeconomic status...
  85. ncbi Posttraumatic growth following breast cancer: a controlled comparison study
    M J Cordova
    Department of Psychology, University of Kentucky, USA
    Health Psychol 20:176-85. 2001
    ..Research that has focused solely on detection of distress and its correlates may paint an incomplete and potentially misleading picture of adjustment to cancer...
  86. ncbi Mental health symptoms following war and repression in eastern Afghanistan
    Willem F Scholte
    Academic Medical Center, Department of Psychiatry, University of Amsterdam, Amsterdam, The Netherlands
    JAMA 292:585-93. 2004
    ..Its Eastern province of Nangarhar is part of the region that originated the Taliban movement. This may have had a distinct impact on the living circumstances and mental health condition of the province's population...
  87. ncbi The functional neuroanatomy of PTSD: a critical review
    Israel Liberzon
    Department of Psychiatry, University of Michigan, MCHC, F6135, Ann Arbor, MI 48109, USA
    Prog Brain Res 167:151-69. 2008
    ..It is proposed that the mPFC plays a role in the "contextualization" of stimuli, and dysregulation of contextualization processes might play a key role in the generation of PTSD symptoms...
  88. ncbi Posttraumatic stress reactions among children following the Athens earthquake of September 1999
    G Kolaitis
    Department of Child Psychiatry, Athens University Medical School, Aghia Sophia Children s Hospital, Thivon and Levadias Str 115, 27 Athens, Greece
    Eur Child Adolesc Psychiatry 12:273-80. 2003
    ....
  89. ncbi Unwanted memories of assault: what intrusion characteristics are associated with PTSD?
    T Michael
    Department of Psychology PO77, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Behav Res Ther 43:613-28. 2005
    ..The results have implications for the early identification of trauma survivors at risk of chronic PTSD...
  90. ncbi Psychological sequelae of the September 11 terrorist attacks in New York City
    Sandro Galea
    Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York, NY 10029 5283, USA
    N Engl J Med 346:982-7. 2002
    ..We assessed the prevalence and correlates of acute post-traumatic stress disorder (PTSD) and depression among residents of Manhattan five to eight weeks after the attacks...
  91. ncbi Response variation following trauma: a translational neuroscience approach to understanding PTSD
    Rachel Yehuda
    Division of Traumatic Stress Studies, Mount Sinai School of Medicine, James J Peters Veteran Affairs, New York, NY 10468, USA
    Neuron 56:19-32. 2007
    ..We emphasize how knowledge about individual differences related to genetic and epigenetic factors in behavioral and brain responses to stress offers the hope of a deeper understanding of PTSD...
  92. pmc Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD
    O Bonne
    Department of Psychiatry, Hadassah University Hospital, P.O. Box 12000, Jerusalem 91120, Israel
    Am J Psychiatry 158:1248-51. 2001
    ..CONCLUSIONS: Smaller hippocampal volume is not a necessary risk factor for developing PTSD and does not occur within 6 months of expressing the disorder. This brain abnormality might occur in individuals with chronic or complicated PTSD...
  93. ncbi Prevalence of psychiatric disorder following the 1988 Yun Nan (China) earthquake--the first 5-month period
    Hua Cao
    Department of Psychiatry, Flinders University of South Australia
    Soc Psychiatry Psychiatr Epidemiol 38:204-12. 2003
    ..The study of culturally distinct groups provides evidence as to the robustness of psychopathology emerging in the context of traumatic exposures...
  94. pmc Exposure to hurricane-related stressors and mental illness after Hurricane Katrina
    Sandro Galea
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA
    Arch Gen Psychiatry 64:1427-34. 2007
    ..Uncertainty exists about the prevalence, severity, and correlates of mental disorders among people exposed to Hurricane Katrina...
  95. pmc The Veterans Health Administration and military sexual trauma
    Rachel Kimerling
    Veterans Administration Health Care System, Palo Alto, Calif, USA
    Am J Public Health 97:2160-6. 2007
    ..We examined the utility of the Veterans Health Administration (VHA) universal screening program for military sexual violence...
  96. ncbi Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
    Lisa M Shin
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    Ann N Y Acad Sci 1071:67-79. 2006
    ..Lastly, the reviewed research suggests diminished volumes, neuronal integrity, and functional integrity of the hippocampus in PTSD. Remaining research questions and related future directions are presented...
  97. ncbi Longitudinal study of psychiatric symptoms, disability, mortality, and emigration among Bosnian refugees
    R F Mollica
    Harvard Program in Refugee Trauma, 8 Story St, Third Floor, Cambridge, MA 02138, USA
    JAMA 286:546-54. 2001
    ..Evidence is emerging that psychiatric disorders are common in populations affected by mass violence. Previously, we found associations among depression, posttraumatic stress disorder (PTSD), and disability in a Bosnian refugee cohort...
  98. ncbi Recall of emotional states in posttraumatic stress disorder: an fMRI investigation
    Ruth A Lanius
    Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
    Biol Psychiatry 53:204-10. 2003
    ....
  99. ncbi Mental health of Cambodian refugees 2 decades after resettlement in the United States
    Grant N Marshall
    RAND, Santa Monica, Calif 90407, USA
    JAMA 294:571-9. 2005
    ..Little is known about the long-term mental health of trauma-exposed refugees years after permanent resettlement in host countries...
  100. ncbi Gray matter density reduction in the insula in fire survivors with posttraumatic stress disorder: a voxel-based morphometric study
    Shulin Chen
    139 Mid Renmin Road Mental Health Institute of The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P R China
    Psychiatry Res 146:65-72. 2006
    ..It was concluded that there are structural abnormalities of the hippocampus, the ACC and the insular cortex in patients with PTSD due to fire...
  101. ncbi Narrative exposure therapy for political imprisonment-related chronic posttraumatic stress disorder and depression
    Dana Bichescu
    Department of Psychology, University of Konstanz, Fach D 25, 78457 Konstanz, Germany
    Behav Res Ther 45:2212-20. 2007
    ..These results indicate that NET may lead to the alleviation of post-traumatic and depression symptoms even when the conditions persist for excessive time periods...

Research Grants78

  1. AMYGDALOID FUNCTION IN FEAR CONDITIONING
    Stephen Maren; Fiscal Year: 2002
    ..The outcome of these experiments will have an important impact on current conceptions of both amygdaloid function and emotional learning and memory. ..
  2. Terrorism and Traumatic Responding: Exposure and Resiliency Factors
    STEVAN HOBFOLL; Fiscal Year: 2009
    ..This will enable examination of the validity of phone estimates of diagnosis of PTSD and depression, in particular. ..
  3. Anxiety and Alcohol Drinking in a Genetic Animal Model of Alcoholism
    JULIA ANN CHESTER; Fiscal Year: 2010
    ..This work may aid in the development of behavioral and pharmacological treatment strategies to reduce the incidence of co-morbid PTSD and alcohol use disorders. ..
  4. Prevalence/Correlates: Psychological Impact of WTC
    David Vlahov; Fiscal Year: 2002
    ..We will use multivariable analyses and hierarchical modeling to address key research hypotheses in this proposal. ..
  5. Community Violence & Youth: Preventing Anxiety Disorders
    MICHELE COOLEY; Fiscal Year: 2004
    ..The results of this R21 project will facilitate the design and later implementation of a full-scale NIMH R01 preventive intervention effectiveness trial. ..
  6. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..The proposed research is hypothesis-driven, is based on strong preliminary evidence, is innovative with high likelihood for novel findings with applicability to humans. ..
  7. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..Our data will fill in fundamental gaps in our understanding of how brain dopamine systems work. This will help researchers who study these other brain disorders. ..
  8. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..Thus the currently proposed studies are significant in terms of clinical implications for limiting cardiac damage in the vulnerable veteran population and for fiscal health of the Department of Veterans Affairs. ..
  9. Role of CD44 in experimental Multiple Sclerosis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..abstract_text> ..
  10. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2013
    ....
  11. Aldosterone Action In The Brain, Hypertension and Inflammation
    ELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012
    ..Understanding under what combination of circumstances activation of the mineralocorticoid receptor in the brain results in heart, vessel and kidney disease is important to develop specific prevention and treatment strategies. ..
  12. Safety signal learning in Rhesus monkeys following early life stressChallenge Ar
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..If so would provide the first model of PTSD in rhesus monkeys. ..
  13. Role of Subdiaphragmatic Vagus in Fibromyalgia Syndrome
    JON DAVID LEVINE; Fiscal Year: 2013
    ..The findings should help tailor specific therapies that may prevent or at least ameliorate their significant suffering. ..
  14. Neuroendocrine Mechanisms and Therapeutics in an Animal Model of PTSD
    DAVID MARK DIAMOND; Fiscal Year: 2013
    ..This research will enhance our understanding of the neurobiology of traumatic memory processing and aid in the development of therapeutic treatments for PTSD. ..
  15. Mechanisms of structural plasticity in stress-related disorders
    Scott J Russo; Fiscal Year: 2013
    ....
  16. Inducible recombination and gene expression in specific neurotransmitter systems
    Steven A Thomas; Fiscal Year: 2012
    ..It is expected that the proposed mouse models will permit significant insights into the etiology, identification and treatment of these disorders. ..
  17. Frontal Lobe Injury and Executive Control of Cognition and Emotion
    Diane Swick; Fiscal Year: 2013
    ..Since these conditions can result in tremendous losses of productivity, the development of more sensitive assessments of brain health can assist in tailoring rehabilitation efforts to the needs of individual patients. ..
  18. Integrated PTSD and Smoking Treatment
    Mark B Powers; Fiscal Year: 2013
    ..Smoking outcomes will be assessed 2, 4, 8, 10, 16, and 24 weeks after quit date. Measure of putative mediators will be assessed repeatedly prior and following the quit date. ..
  19. Sex Differences in Stress Receptors Underlie Female Vulnerability to Stress
    Debra A Bangasser; Fiscal Year: 2012
    ..This project will not only help us understand why women are more vulnerable to stress-related mental illnesses, but it will identify new pharmaceutical targets which can lead to treatments that are efficacious in both men and women. ..
  20. Identification of an Epigenetic Risk Marker for PTSD
    Rachel Yehuda; Fiscal Year: 2010
    ..e., pretraumatic) biologic marker that can ultimately be used in screening persons at increased risk for PTSD either before or immediately after they are exposed to trauma. ..
  21. A Cohort Study of Preterm Delivery in Relation to Partner Abuse, Mood and Anxiety
    Michelle A Williams; Fiscal Year: 2013
    ..S. Congress'passing of the Prematurity Research Expansion and Education for Mothers who Deliver Infants Early (PREEMIE) Act (P.L. 109-450)234. ..
  22. Sex Differences in Stress Receptors Underlie Female Vulnerability to Stress
    Debra A Bangasser; Fiscal Year: 2013
    ..Moreover, because CRF antagonists are being developed to treat these illnesses, considering sex differences in CRF receptors may increase the efficacy of these compounds in women. ..
  23. The role of BNST CGRP in stress-enhanced anxiety behavior and HPA-axis function
    Kelly S Sink; Fiscal Year: 2013
    ....
  24. Impaired hippocampal function as a risk factor for Post-Traumatic Stress Disorder
    Almira Vazdarjanova; Fiscal Year: 2013
    ..Findings from Aim 3 will suggest investigating treatments to confer resilience that have a high compliance rate, as they will be low-stress. ..
  25. Melanocortin Signaling in Depression
    Michael Lutter; Fiscal Year: 2013
    ..The purpose of this research is to investigate the link between mood disorders and feeding and body weight regulation. ..
  26. TWIN STUDY OF BIOLOGIC MARKERS FOR PTSD
    Lisa M Shin; Fiscal Year: 2012
    ..Abnormalities that are found to be acquired could become the target of PTSD treatments, whereas abnormalities that serve as risk factors for PTSD could be used in screening for persons at risk and possible preventive interventions. ..
  27. Regulation of AKAP79 Postsynaptic Targeting and Signaling
    MARK L DELL'ACQUA; Fiscal Year: 2013
    ....
  28. Functional Anatomy of REM Sleep: Brainstem-Control
    Gerald A Marks; Fiscal Year: 2013
    ..This research proposal hopes to contribute to our knowledge on the role of REM sleep mechanisms in the etiology and reinforcement of these disorders. ..
  29. OEF/OIF Veterans with PTSD in Mental Health Residential Treatment Programs
    Eric Slade; Fiscal Year: 2013
    ....
  30. Screening New Therapeutics for the Treatment of Post Traumatic Stress Disorder
    NEAL GORDON SIMON; Fiscal Year: 2011
    ..This proposal will use a unique predatory fear conditioning paradigm as a preclinical model to test the feasibility of using novel V1a antagonists as a potential new pharmacotherapy for PTSD. ..
  31. Neuroimmune Factors and Co-Morbid Fear, Depression and Alcohol Consumption
    Michael S Fanselow; Fiscal Year: 2010
    ..We will also determine if pharmacologically interfering with these neuroimmune pathways mitigate the symptoms of PTSD. ..
  32. Immunopathological basis of PTSD
    Prakash S Nagarkatti; Fiscal Year: 2013
    ....
  33. Live imaging of brain circuitry in mouse models of PTSD
    Elaine L Bearer; Fiscal Year: 2013
    ....
  34. Mechanisms of Stress-Enhanced Aversive Conditioning
    Jelena Radulovic; Fiscal Year: 2013
    ..Targeting selected protein kinases among a multitude of receptor-activated pathways will increase the specificity while minimizing side effects of emerging treatments for fear symptoms in PTSD and ASD. ..
  35. Brain Matters 3: Values at the Crossroads of Neurology, Psychiatry, and Psycholog
    PAUL JASON FORD; Fiscal Year: 2012
    ..In particular there is a focus on Psychogenic Non-epileptic Seizures, but a generalization to broader conditions such as post-traumatic stress disorder, pain syndromes, and psychogenic movement disorders. ..
  36. Preventive Web-Based Intervention for Spouses of Traumatized Military Personnel
    BENTSON H contact MCFARLAND; Fiscal Year: 2010
    ....
  37. Genetic and estrogen-dependent regulation of the human PAC1R receptor and PTSD
    Kerry J Ressler; Fiscal Year: 2013
    ..We will further examine the mechanisms of PAC1 regulation using human lymphoblast cell lines of differing PAC1 rs2267735 genotypes. ..
  38. Telehealth Tinnitus Intervention for Patients with TBI
    JAMES A contact HENRY; Fiscal Year: 2011
    ..Adaptation of PTM as a home-based telehealth service has the potential of providing needed tinnitus services to Veterans with and without TBI for a relatively small cost and with minimal impact on individual VA hospitals. ..
  39. Discontinuing NSAIDs in Veterans with Knee Osteoarthritis
    Liana Fraenkel; Fiscal Year: 2013
    ..The proposed strategy is particularly appealing because it replaces the widespread use of NSAIDs with a safer alternative, enables delivery of care to Veterans with limited access, and is likely to be cost saving. ..
  40. Modeling Individual Differences in PTSD
    Marlene A Wilson; Fiscal Year: 2013
    ....
  41. High Sensitivity Mobile PET for Brain Imaging and Proton Therapy Monitoring
    Georges El Fakhri; Fiscal Year: 2010
    ..in movement disorders and in psychiatric disorders such as obsessive compulsive disorders and post traumatic stress disorders and in lung injury and coronary artery diseases in animal models...
  42. Chromatin remodeling mechanisms of gene transcription in memory
    Farah D Lubin; Fiscal Year: 2013
    ....
  43. Physiological and Emotional Reactivity to Pain after Physical and Sexual Abuse
    KARIN N WESTLUND-HIGH; Fiscal Year: 2011
    ....
  44. Neuronal Mechanisms for Fear Memory Generalization in PTSD and Anxiety Disorders
    Wei Xu; Fiscal Year: 2013
    ..Stanford University has been the cradle of fundamental neuroscience findings and innovative neuroscience approaches and will furnish the best environment for the studies. ..
  45. Cytokine Signaling as a Mediator of Fear and Anxiety After Myocardial Infarction
    NATALIE CELIA TRONSON; Fiscal Year: 2012
    ....
  46. Stress-Induced Gene Regulation: BNST CRF Neurons and the Physiology of Anxiety
    Donald G Rainnie; Fiscal Year: 2013
    ....
  47. Prognosis and Determinants of Asthma Morbidity in World Trade Center Rescue and R
    Juan P Wisnivesky; Fiscal Year: 2013
    ..We will use psychiatric interviews to assess major depression and post traumatic stress disorders (PTSD) in WTC workers with asthma...
  48. Brain injury due to transcranial versus transthoracic blast exposure
    J Marc Simard; Fiscal Year: 2013
    ....
  49. The Iowa Flood Study: Perinatal Effects of a Natural Disaster
    MICHAEL WILLIAM O apos HARA; Fiscal Year: 2010
    ..This work will have implications for our understanding of biopsychosocial nature of the effects of stress on maternal mental health and infant health. ..
  50. Roles of Nucleus Accumbens CREB and Kappa Function in Depression
    William A Carlezon; Fiscal Year: 2013
    ..We will also test the hypothesis that KOR disruption blocks stress-induced alterations in microRNA (miR) expression in the mesocorticolimbic system. This work may provide a basis for improved diagnostics and therapeutics. ..
  51. Treatment of Smoking Among Individuals with PTSD
    Edna B Foa; Fiscal Year: 2012
    ....
  52. Transgenic Tethered Peptides
    Michael N Nitabach; Fiscal Year: 2013
    ..Their amelioration will be facilitated by understanding the normal in vivo functions served by the numerous neuropeptides encoded in metazoan genomes. ..
  53. Developmental effects of 5-HTT genotype on stress reactivity and brain function
    Moriah E Thomason; Fiscal Year: 2010
    ....
  54. ORGANIZATION OF PREFRONTAL FEEDBACK CIRCUITS
    Helen Barbas; Fiscal Year: 2013
    ....
  55. A randomized cross over trial of two treatments for OSA in Veterans with PTSD
    ALI ALBERT EL SOLH; Fiscal Year: 2013
    ..This feasibility study would form the basis of a future trial examining the effectiveness of various therapeutic modalities for OSA on PTSD symptomatology and progression. ..
  56. Effects of early-life experience:role of CRH
    Tallie Z Baram; Fiscal Year: 2013
    ..The resulting information would enable us to use the same mechanisms as a basis for therapy in people who have not had the same type of optimal childhood experience. ..
  57. Group I Metabotropic Glutamate Receptors and Epileptogenesis
    Paul A Rutecki; Fiscal Year: 2013
    ....
  58. Behavioral and Molecular Analysis of Chromatin Modifications in Memory Retrieval
    James M Stafford; Fiscal Year: 2012
    ....
  59. CRCNS: PKMzeta-Dependent Protein Synthesis Maintains Synaptic Plasticity
    HAREL ZEEV SHOUVAL; Fiscal Year: 2013
    ..We are eager to extend this type of outreach to the domain of the interaction between theory and experiment in biological sciences. ..
  60. Developmental Genetics of Serotonin Neuron Subtypes in Brain Reward Circuits
    Susan M Dymecki; Fiscal Year: 2010
    ....
  61. Regulation of transcription by chromatin modifying enzymes in extinction learning
    Ruth M Barrett; Fiscal Year: 2010
    ..Furthermore, histone deacetylase inhibitors are FDA approved drugs, which significantly increases the potential translational value of this research. ..
  62. Informing Decisions in Chronic Critical Illness: An RCT
    Judith E Nelson; Fiscal Year: 2013
    ....
  63. A Cognitive Neuroscience Framework for Understanding and Treating Mood Disorders
    Moshe Bar; Fiscal Year: 2012
    ..for better understanding a host of mood disorders such as, attention-deficit, bi-polar and post traumatic stress disorders, for contextualizing adult hippocampal neurogenesis, and more generally, for increasing well-being ..
  64. Brain pH and Acid Sensing in Depression-Related Behavior
    John A Wemmie; Fiscal Year: 2013
    ..In this proposal, we will determine the contribution of brain pH to ASIC1a channel activity, and test whether ASIC1a and brain pH might be targeted to reduce depression. ..
  65. Emergency Contraception to Prevent Pregnancy: Missed Opportunities for Care.
    MICHELLE LYNNE MUNRO; Fiscal Year: 2012
    ....
  66. Molecular Determinants of Individual Differences in Fear Reactivity and Recovery
    Joseph E LeDoux; Fiscal Year: 2013
    ..These comprehensive studies will determine specific molecular targets for future focused research of fear-related behaviors and illnesses. ..
  67. Stress and Noradrenergic Modulation of A10dc Dopamine Neurons
    MEGAN A FETTIG; Fiscal Year: 2013
    ..We propose to use this model to determine how stress and norepinephrine modulate glutamatergic transmission and excitability of the A10dc neurons. ..
  68. Non-intrusive Locomotion and Gait Stability Analysis Monitoring System for the El
    Sunil Saxena; Fiscal Year: 2007
    ..Human subjects testing in collaboration with Virginia Tech will be conducted during Phase I to demonstrate feasibility. [unreadable] [unreadable] [unreadable] [unreadable]..
  69. Extinction of Fear Memories with Glucocorticoids in Veterans with PTSD
    Alina Suris; Fiscal Year: 2009
    ..The information gained from this study will be applicable not only to veterans who have combat-related PTSD, but to any individual with suffering intrusive memories from any type of trauma. ..
  70. Web-Based Interactive Multimedia CBT Bereavement Support Program
    VICKY GELATT; Fiscal Year: 2010
    ..5 billion in increased health utilization, absenteeism, reduced productivity (presenteeism) and errors/accidents due to poor concentration. ..
  71. Mentored Patient-Oriented Research Career Development Aw
    Kelly Young; Fiscal Year: 2004
    ..Elucidation of factors influencing children's pain response, and study of interventions to reduce pain, are important priorities for all clinicians who care for children. ..
  72. Use of a Novel Neuroplasticity-based Neurobehavioral Intervention for PTSD
    Amit Etkin; Fiscal Year: 2012
    ....
  73. Cellular mechanisms mediating extinction of conditioned fear
    Vadim Bolshakov; Fiscal Year: 2009
    ..A better knowledge of the cellular mechanisms of fear-related behavior will permit the rational development of novel therapeutic treatments for posttraumatic stress disorder (PTSD) and generalized anxiety. ..
  74. Glucocorticoid mechanisms of neonatal separation effects on adult learning
    Aaron A Wilber; Fiscal Year: 2009
    ..S. citizens are affected by mental disorders every year. Understanding the mental health consequences of intentional (e.g., abuse and neglect) and unintentional (e.g., NICU) perinatal stressors is crucial to preventative treatment. ..
  75. Serotonin Club Meeting 2010
    JULIE GORTON HENSLER; Fiscal Year: 2010
    ....
  76. The Role of Corticotropin-Releasing Factor in Primate Maternal Behavior
    Wendy Saltzman; Fiscal Year: 2007
    ..Ultimately, this research will have implications for the understanding and treatment of stress-related psychopathology in women. [unreadable] [unreadable] [unreadable]..
  77. SOCIAL STATUS AND PTSD IN U.S. VIETNAM VETERANS
    BRUCE DOHRENWEND; Fiscal Year: 2001
    ..The long term goal is to increase knowledge of how humans adapt or fail to adapt to adversity and stress, and to contribute to the account of an historic event in the life of this nation. ..
  78. Murine model of CRF effects on fear extinction: relevance to PTSD
    Victoria Risbrough; Fiscal Year: 2007
    ..The results of these studies could lead to a new line of investigation involving an innovative combination of pharmacological and experience-based treatments using CRF-R1 antagonists to treat PTSD. [unreadable] [unreadable] [unreadable]..