panic disorder

Summary

Summary: A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin with intense apprehension, fear or terror and, often, a feeling of impending doom. Symptoms experienced during a panic attack include dyspnea or sensations of being smothered; dizziness, loss of balance or faintness; choking sensations; palpitations or accelerated heart rate; shakiness; sweating; nausea or other form of abdominal distress; depersonalization or derealization; paresthesias; hot flashes or chills; chest discomfort or pain; fear of dying and fear of not being in control of oneself or going crazy. Agoraphobia may also develop. Similar to other anxiety disorders, it may be inherited as an autosomal dominant trait.

Top Publications

  1. ncbi Neurosteroid secretion in panic disorder
    Francesca Brambilla
    Dipartimento di Scienze Neuropsichiche, Istituto Scientifico Ospedale S Raffaele, Universita Vita e Salute, Milan, Italy
    Psychiatry Res 118:107-16. 2003
  2. ncbi Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder
    E A Hoge
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 26:447-55. 2009
  3. ncbi EEG alpha asymmetry in schizophrenia, depression, PTSD, panic disorder, ADHD and conduct disorder
    Evian Gordon
    Brain Resource Ltd, Sydney, Australia
    Clin EEG Neurosci 41:178-83. 2010
  4. pmc Evidence-based guidelines for interpretation of the Panic Disorder Severity Scale
    Toshi A Furukawa
    Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuhocho, Mizuho ku, Nagoya 467 8601, Japan
    Depress Anxiety 26:922-9. 2009
  5. ncbi Neuropeptide S receptor gene -- converging evidence for a role in panic disorder
    K Domschke
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Mol Psychiatry 16:938-48. 2011
  6. ncbi Remote treatment of panic disorder: a randomized trial of internet-based cognitive behavior therapy supplemented with telephone calls
    Per Carlbring
    Department of Behavioural Sciences, Linkoping University, SE 581 83 Linkoping, Sweden
    Am J Psychiatry 163:2119-25. 2006
  7. pmc Clinical and subthreshold panic disorder
    Alexander Bystritsky
    The Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California 90095 8346, USA
    Depress Anxiety 27:381-9. 2010
  8. ncbi A genome-wide CNV association study on panic disorder in a Japanese population
    Yoshiya Kawamura
    Outpatient Clinic for Anxiety Disorders, Yokohama Clinic, Yokohama, Japan
    J Hum Genet 56:852-6. 2011
  9. ncbi Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex emotional processing in panic disorder
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Albert Schweitzer Str 11, D 48143 Muenster, Germany
    Psychiatry Res 163:13-20. 2008
  10. ncbi Prevention of panic attacks and panic disorder in COPD
    N Livermore
    Dept of Liaison Psychiatry, Prince of Wales Hospital, NSW, Australia
    Eur Respir J 35:557-63. 2010

Detail Information

Publications354 found, 100 shown here

  1. ncbi Neurosteroid secretion in panic disorder
    Francesca Brambilla
    Dipartimento di Scienze Neuropsichiche, Istituto Scientifico Ospedale S Raffaele, Universita Vita e Salute, Milan, Italy
    Psychiatry Res 118:107-16. 2003
    ..In 25 female patients with panic disorder (PD) and 11 healthy female controls, we measured plasma concentrations of progesterone (PROG), pregnenolone (..
  2. ncbi Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder
    E A Hoge
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 26:447-55. 2009
    ..Much less is known about cytokines in anxiety disorders such as posttraumatic stress disorder (PTSD) and panic disorder (PD)...
  3. ncbi EEG alpha asymmetry in schizophrenia, depression, PTSD, panic disorder, ADHD and conduct disorder
    Evian Gordon
    Brain Resource Ltd, Sydney, Australia
    Clin EEG Neurosci 41:178-83. 2010
    ..Overall, the results of the current study indicate that EEG alpha asymmetry may show the most clinical utility as a biomarker for schizophrenia and depression in comparison to other clinical disorders...
  4. pmc Evidence-based guidelines for interpretation of the Panic Disorder Severity Scale
    Toshi A Furukawa
    Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuhocho, Mizuho ku, Nagoya 467 8601, Japan
    Depress Anxiety 26:922-9. 2009
    The Panic Disorder Severity Scale (PDSS) is promising to be a standard global rating scale for panic disorder...
  5. ncbi Neuropeptide S receptor gene -- converging evidence for a role in panic disorder
    K Domschke
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Mol Psychiatry 16:938-48. 2011
    ..The functional NPSR A/T (Asn¹⁰⁷Ile) variant (rs324981) was investigated for association with (1) panic disorder with and without agoraphobia in two large, independent case-control studies, (2) dimensional anxiety traits, (..
  6. ncbi Remote treatment of panic disorder: a randomized trial of internet-based cognitive behavior therapy supplemented with telephone calls
    Per Carlbring
    Department of Behavioural Sciences, Linkoping University, SE 581 83 Linkoping, Sweden
    Am J Psychiatry 163:2119-25. 2006
    This study evaluated a 10-week Internet-based bibliotherapy self-help program with short weekly telephone calls for people suffering from panic disorder with or without agoraphobia.
  7. pmc Clinical and subthreshold panic disorder
    Alexander Bystritsky
    The Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California 90095 8346, USA
    Depress Anxiety 27:381-9. 2010
    b>Panic disorder (PD) is a highly prevalent and disabling condition, and subthreshold cases may be even more prevalent...
  8. ncbi A genome-wide CNV association study on panic disorder in a Japanese population
    Yoshiya Kawamura
    Outpatient Clinic for Anxiety Disorders, Yokohama Clinic, Yokohama, Japan
    J Hum Genet 56:852-6. 2011
    Family and twin studies have indicated that genetic factors have an important role in panic disorder (PD), whereas its pathogenesis has remained elusive...
  9. ncbi Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex emotional processing in panic disorder
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Albert Schweitzer Str 11, D 48143 Muenster, Germany
    Psychiatry Res 163:13-20. 2008
    b>Panic disorder is an anxiety disorder with an estimated heritability of up to 48%...
  10. ncbi Prevention of panic attacks and panic disorder in COPD
    N Livermore
    Dept of Liaison Psychiatry, Prince of Wales Hospital, NSW, Australia
    Eur Respir J 35:557-63. 2010
    ..Primary outcomes were the rates of panic attacks, panic disorder and anxiety symptoms...
  11. ncbi Harm avoidance and self-directedness as essential features of panic disorder patients
    Cláudia Wachleski
    Anxiety Disorder Program, Hospital de Clínicas de Porto Alegre and Graduate Program in Medical Sciences, Psychiatry, Universidade Federal do Rio Grande do Sul, Brazil
    Compr Psychiatry 49:476-81. 2008
    The purpose of the study is to compare the personality traits assessed with the Temperament and Character Inventory (TCI) between patients with panic disorder (PD) and a control group in a Brazilian sample.
  12. ncbi Detecting panic disorder in medical and psychosomatic outpatients: comparative validation of the Hospital Anxiety and Depression Scale, the Patient Health Questionnaire, a screening question, and physicians' diagnosis
    Bernd Löwe
    Department of General Internal and Psychosomatic Medicine, University of Heidelberg, Medical Hospital, Bergheimer Strasse 58, D 69115, Heidelberg, Germany
    J Psychosom Res 55:515-9. 2003
    To compare the validity of detecting panic disorder using the Hospital Anxiety and Depression Scale (HADS), the Patient Health Questionnaire (PHQ), a screening question, and physicians' diagnosis, and to test whether modified evaluation ..
  13. pmc Usage and longitudinal effectiveness of a Web-based self-help cognitive behavioral therapy program for panic disorder
    Peter Farvolden
    Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada
    J Med Internet Res 7:e7. 2005
    ..However, there is little data regarding the patterns of use and effectiveness of freely available Web-based interventions outside the context of controlled trials...
  14. ncbi A modern learning theory perspective on the etiology of panic disorder
    M E Bouton
    Department of Psychology, University of Vermont, Burlington, Vermont 05405, USA
    Psychol Rev 108:4-32. 2001
    Several theories of the development of panic disorder (PD) with or without agoraphobia have emerged in the last 2 decades. Early theories that proposed a role for classical conditioning were criticized on several grounds...
  15. pmc Internet-versus group-administered cognitive behaviour therapy for panic disorder in a psychiatric setting: a randomised trial
    Jan Bergstrom
    Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
    BMC Psychiatry 10:54. 2010
    ..The primary aim of this study was to compare the effectiveness of Internet-and group administered CBT for panic disorder (with or without agoraphobia) in a randomised trial within a regular psychiatric care setting...
  16. ncbi Neuroanatomical hypothesis of panic disorder, revised
    J M Gorman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, USA
    Am J Psychiatry 157:493-505. 2000
    In a 1989 article, the authors provided a hypothesis for the neuroanatomical basis of panic disorder that attempted to explain why both medication and cognitive behavioral psychotherapy are effective treatments...
  17. ncbi Relationships among psychosocial functioning, diagnostic comorbidity, and the recurrence of generalized anxiety disorder, panic disorder, and major depression
    Benjamin F Rodriguez
    Department of Psychology, Southern Illinois University, Life Sciences II Room 222A, Carbondale, IL 62901 6502, USA
    J Anxiety Disord 19:752-66. 2005
    ..impairment in general and in specific areas was significantly associated with an increased risk of panic disorder, generalized anxiety disorder, and major depression recurring, even after controlling for diagnostic ..
  18. pmc Posttyphoon prevalence of posttraumatic stress disorder, major depressive disorder, panic disorder, and generalized anxiety disorder in a Vietnamese sample
    Ananda B Amstadter
    National Crime Victims Research and Treatment Center, PO Box 250852, Charleston, SC 29425, USA
    J Trauma Stress 22:180-8. 2009
    ..and risk factors associated with posttraumatic stress disorder (PTSD), major depressive disorder (MDD), panic disorder (PD), and generalized anxiety disorder (GAD). Posttyphoon prevalences were PTSD 2.6%, MDD 5.9%, PD 9...
  19. ncbi Fronto-temporo-insula gray matter alterations of first-episode, drug-naïve and very late-onset panic disorder patients
    Chien Han Lai
    Department of Psychiatry, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan
    J Affect Disord 140:285-91. 2012
    There is no voxel-based morphometry study for first-episode, drug-naïve and very late-onset panic disorder patients. Besides, differences of onset age might represent different clinical subgroups...
  20. ncbi First episode drug-naïve major depressive disorder with panic disorder: gray matter deficits in limbic and default network structures
    Chien Han Lai
    Department of Psychiatry, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan
    Eur Neuropsychopharmacol 20:676-82. 2010
    ..structural differences in the brains of first episode, drug-naïve patients with major depressive disorder and panic disorder versus healthy control subjects...
  21. ncbi Effectiveness of internet-based cognitive behaviour therapy for panic disorder in routine psychiatric care
    E Hedman
    Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm Department of Clinical Neuroscience, Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm Department of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm
    Acta Psychiatr Scand 128:457-67. 2013
    Guided Internet-based cognitive behaviour therapy (ICBT) for panic disorder has been shown to be efficacious in several randomized controlled trials...
  22. ncbi Current findings of fMRI in panic disorder: contributions for the fear neurocircuitry and CBT effects
    Marcele Regine de Carvalho
    Laboratory of Panic and Respiration, Institute of Psychiatry, Universidade Federal do Rio de Janeiro UFRJ, Rio de Janeiro, Brazil
    Expert Rev Neurother 10:291-303. 2010
    ..to brain imaging great advances have been made concerning the comprehension of neural substrates related to panic disorder (PD)...
  23. pmc Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder
    Christian Grillon
    NIMH MAP, 15K North Dr, Bldg 15k, Rm 113, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 165:898-904. 2008
    ..In panic disorder, persistent symptoms of anxiety are caused by anticipation of the next uncued (unpredictable) panic attack...
  24. pmc The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Arch Gen Psychiatry 63:415-24. 2006
    Only limited information exists about the epidemiology of DSM-IV panic attacks (PAs) and panic disorder (PD).
  25. ncbi Neural correlates of the emotional Stroop task in panic disorder patients: an event-related fMRI study
    Thomas Dresler
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Germany
    J Psychiatr Res 46:1627-34. 2012
    ..functional magnetic resonance imaging (fMRI) to examine the attentional bias toward panic-related words in panic disorder (PD) patients and healthy controls...
  26. ncbi Antioxidant enzyme and malondialdehyde levels in patients with panic disorder
    Murat Kuloglu
    Department of Psychiatry, Medical Faculty, Firat University, Elazig, Turkey
    Neuropsychobiology 46:186-9. 2002
    ..SOD) and catalase (CAT)] and malondialdehyde (MDA), a product of lipid peroxidation, were associated with panic disorder (PD). Twenty patients diagnosed with PD and 20 healthy controls were enrolled in this study...
  27. pmc Individually tailored internet-based treatment for young adults and adults with panic attacks: randomized controlled trial
    Kristin Silfvernagel
    Department of Behavioural Sciences and Learning, Linkoping University, Linkoping, Sweden
    J Med Internet Res 14:e65. 2012
    ..Previous studies on Internet-based treatment with minimal therapist guidance have shown promising results for several specific diagnoses...
  28. ncbi Acute exercise ameliorates reduced brain-derived neurotrophic factor in patients with panic disorder
    Andreas Strohle
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Psychoneuroendocrinology 35:364-8. 2010
    ..To further characterize the association of anxiety, BDNF and exercise, we studied panic disorder patients (n=12) and individually matched healthy control subjects (n=12) in a standardized exercise paradigm...
  29. ncbi The genetics of panic disorder
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Germany
    J Med Genet 48:361-8. 2011
    b>Panic disorder (PD) is one of the most common anxiety disorders, with a prevalence of 3.4-4.7%...
  30. ncbi Individual differences in fear-potentiated startle as a function of resting heart rate variability: implications for panic disorder
    Christiane A Melzig
    Department of Biological and Clinical Psychology, University of Greifswald, Germany
    Int J Psychophysiol 71:109-17. 2009
    ..can be indexed by the startle potentiation to a threat of shock, has been implicated in the development of panic disorder. Large individual differences exist in startle potentiation to threat of shock but few differences have been ..
  31. ncbi Frontal regional homogeneity increased and temporal regional homogeneity decreased after remission of first-episode drug-naïve major depressive disorder with panic disorder patients under duloxetine therapy for 6 weeks
    Chien Han Lai
    Department of Psychiatry, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan
    J Affect Disord 136:453-8. 2012
    We designed this study to investigate the changes of regional homogeneity (ReHo) after a 6-week duloxetine therapy in first-episode drug-naïve major depressive disorder with panic disorder (FEMDDPD) patients.
  32. ncbi Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptide-induced panic attacks: preliminary findings
    K Wiedemann
    Department of Psychiatry and Psychotherapy, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Arch Gen Psychiatry 58:371-7. 2001
    ....
  33. pmc Carbon dioxide inhalation induces dose-dependent and age-related negative affectivity
    Eric J Griez
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    PLoS ONE 2:e987. 2007
    Carbon dioxide inhalation is known to induce an emotion similar to spontaneous panic in Panic Disorder patients. The affective response to carbon dioxide in healthy subjects was not clearly characterized yet.
  34. ncbi GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment
    Andreas Strohle
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Psychiatry 159:145-7. 2002
    ..However, no data on the possible role of these gamma-aminobutyric acid(A) (GABA(A)) receptor-modulating neuroactive steroids in patients with anxiety disorders are available...
  35. ncbi Antipanic drug modulation of 35% CO2 hyperreactivity and short-term treatment outcome
    Giampaolo Perna
    The Anxiety Disorder Clinical and Research Unit, Department of Neuropsychiatric Sciences, University of Milan, Istituto Scientifico Ospedale San Raffaele, Italy
    J Clin Psychopharmacol 22:300-8. 2002
    Carbon dioxide (CO2) inhalation induces acute anxiety and panic attacks in patients with Panic Disorder (PD)...
  36. pmc Headache, anxiety and depressive disorders: the HADAS study
    Ettore Beghi
    Dipartimento di Neuroscienze, Istituto Mario Negri, Milan, Italy
    J Headache Pain 11:141-50. 2010
    ..9, 67.0, and 69.6% of cases. Values were 18.4, 19.3, and 18.4% for anxiety, 12.7, 5.5, and 14.2%, for panic disorder and 2.3, 1.1 and 9.4% (p = 0.009) for obsessive-compulsive disorder...
  37. ncbi Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways
    Margarita Muiños-Gimeno
    Genes and Disease Program, Centre for Genomic Regulation CRG, Public Health and Epidemiology Network Biomedical Research Center CIBERESP, Barcelona, Catalonia, Spain
    Biol Psychiatry 69:526-33. 2011
    ..neuronal differentiation and synaptic plasticity suggests a role for miRNAs in psychiatric disorders; association analyses and functional approaches were used to evaluate the implication of miRNAs in the susceptibility for panic disorder.
  38. ncbi Sexually dimorphic gray matter volume reduction in patients with panic disorder
    Takeshi Asami
    Department of Psychiatry, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Psychiatry Res 173:128-34. 2009
    While clinical features of panic disorder show significant sexual dimorphism, previous structural MRI studies have not sufficiently controlled for sex when looking at regional brain abnormalities in panic disorder...
  39. ncbi Smaller amygdala is associated with anxiety in patients with panic disorder
    Fumi Hayano
    Department of Psychiatry, Graduate School of Medicine, Yokohama City University, Kanagawa, Japan
    Psychiatry Clin Neurosci 63:266-76. 2009
    Anxiety a core feature of panic disorder, is linked to function of the amygdala...
  40. ncbi Anxiety sensitivity: prospective prediction of panic attacks and Axis I pathology
    Norman B Schmidt
    Department of Psychology, Florida State University, Tallahassee, 32306, USA
    J Psychiatr Res 40:691-9. 2006
    ..These are the first data to provide strong prospective evidence for AS as a risk factor in the development of anxiety disorders...
  41. pmc Overgeneralization of conditioned fear as a pathogenic marker of panic disorder
    Shmuel Lissek
    Mood and Anxiety Disorders Program, NIMH Intramural Research Program, Bethesda, MD, USA
    Am J Psychiatry 167:47-55. 2010
    Classical conditioning features prominently in many etiological accounts of panic disorder. According to such accounts, neutral conditioned stimuli present during panic attacks acquire panicogenic properties...
  42. ncbi Psychological treatment of panic disorder with or without agoraphobia: a meta-analysis
    Julio Sánchez-Meca
    Dept Basic Psychology and Methodology, Faculty of Psychology, University of Murcia, Spain
    Clin Psychol Rev 30:37-50. 2010
    Although the efficacy of psychological treatment for panic disorder (PD) with or without agoraphobia has been the subject of a great deal of research, the specific contribution of techniques such as exposure, cognitive therapy, relaxation ..
  43. ncbi Efficacy of d-cycloserine for enhancing response to cognitive-behavior therapy for panic disorder
    Michael W Otto
    Center for Anxiety and Related Disorders at Boston University, Massachusetts 02215, USA
    Biol Psychiatry 67:365-70. 2010
    ..Enhancement of cognitive-behavior therapy with d-cycloserine (DCS) pharmacotherapy represents a novel strategy for improving therapeutic learning from cognitive-behavior therapy that remains untested in panic disorder.
  44. pmc Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorder
    Shmuel Lissek
    Mood and Anxiety Disorders Program, National Institute of Mental Health Intramural Research Program, NIH, DHHS, MD 20892 2670, USA
    Behav Res Ther 47:111-8. 2009
    Classical fear-conditioning is central to many etiologic accounts of panic disorder (PD), but few lab-based conditioning studies in PD have been conducted...
  45. pmc The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder
    Tina B Lonsdorf
    Psychology Section, Karolinska Institutet, Fogdevreten 2A, 17176 Stockholm, Sweden
    BMC Psychiatry 10:99. 2010
    ..CBT for panic disorder is based on exposure and exposure-based processes can be studied in the laboratory as extinction of ..
  46. ncbi Internet-based treatment for panic disorder: does frequency of therapist contact make a difference?
    Britt Klein
    Faculty of Life and Social Sciences, National eTherapy Centre, Swinburne University, Hawthorn, Victoria 3122, Australia
    Cogn Behav Ther 38:100-13. 2009
    ..Fifty-seven people with panic disorder (including 32 with agoraphobia) were randomly allocated to an 8-week Internet-based cognitive behavioural ..
  47. ncbi Anterior cingulate cortex volume reduction in patients with panic disorder
    Takeshi Asami
    Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan
    Psychiatry Clin Neurosci 62:322-30. 2008
    ..studies have suggested that the anterior cingulate cortex (ACC) has an important role in the pathology of panic disorder. Despite numerous functional neuroimaging studies that have elucidated the strong relationship between ..
  48. pmc Panic, suffocation false alarms, separation anxiety and endogenous opioids
    Maurice Preter
    New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, 1160 Fifth Avenue, Suite 112, New York, NY 10029, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:603-12. 2008
    ....
  49. ncbi Cognitive behavioural therapy for depression, panic disorder and generalized anxiety disorder: a meta-regression of factors that may predict outcome
    Michelle M Haby
    Health Surveillance and Evaluation Section, Public Health Group, Department of Human Services, Melbourne, Victoria, Australia
    Aust N Z J Psychiatry 40:9-19. 2006
    ..Factors related to the conduct of the trial were also considered, including: year of study, country of study, type of control group, language, number of patients and percentage of dropouts from the trial...
  50. ncbi Multicenter collaborative panic disorder severity scale
    M K Shear
    Department of Psychiatry, University of Pittsburgh, PA, USA
    Am J Psychiatry 154:1571-5. 1997
    To address the lack of a simple and standardized instrument to assess overall panic disorder severity, the authors developed a scale for the measurement of panic disorder severity.
  51. ncbi Childhood abuse and familial violence and the risk of panic attacks and panic disorder in young adulthood
    Renee D Goodwin
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 1051 Riverside Drive, Unit 43, New York, NY 10032, USA
    Psychol Med 35:881-90. 2005
    ..between exposure to childhood abuse and interparental violence and the subsequent development of panic attacks and panic disorder using data gathered on a birth cohort of 1265 New Zealand young people studied to the age of 21 years.
  52. ncbi Temporal and right frontal lobe alterations in panic disorder: a quantitative volumetric and voxel-based morphometric MRI study
    T Sobanski
    Department of Psychiatry and Psychotherapy, University of Jena, Germany
    Psychol Med 40:1879-86. 2010
    With regard to current neurobiological theories, the aim of our study was to examine possible alterations of temporal and frontal lobe volume in panic disorder (PD).
  53. ncbi An experimental investigation of the impact of biological and psychological causal explanations on anxious and depressed patients' perception of a person with panic disorder
    Danny C K Lam
    Kingston University St George s, University of London
    Behav Res Ther 45:405-11. 2007
    ..Prior to watching a video of a person suffering from panic disorder, participants were told either that research indicated that panic was caused by biological factors, by ..
  54. ncbi Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder
    Paul G Unschuld
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 München, Germany
    J Affect Disord 105:177-84. 2008
    ..Furthermore, GAL is involved in hypothalamic-hypophysiotropic signalling and cosecreted with luteinizing hormone-releasing hormone (LHRH), possibly acting as a mediator of estrogen action...
  55. ncbi The prevalence of mood and anxiety disorders in Australian women
    Lana Williams
    Department of Clinical and Biomedical Sciences, Barwon Health, The University of Melbourne, Geelong, Vic, Australia
    Australas Psychiatry 18:250-5. 2010
    ..We aimed to report the prevalence, age-of-onset and comorbidity of mood and anxiety disorders in an age-stratified representative sample of Australian women aged 20 years and over...
  56. pmc Unstable prefrontal response to emotional conflict and activation of lower limbic structures and brainstem in remitted panic disorder
    Natalya Chechko
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e5537. 2009
    The neural mechanisms of panic disorder (PD) are only incompletely understood. Higher sensitivity of patients to unspecific fear cues and similarities to conditioned fear suggest involvement of lower limbic and brainstem structures...
  57. ncbi Neuroticism moderates the effect of maximum smoking level on lifetime panic disorder: a test using an epidemiologically defined national sample of smokers
    Michael J Zvolensky
    Department of Psychology, University of Vermont, 2 Colchester Avenue, John Dewey Hall, Burlington, VT 05405 0134, USA
    Psychiatry Res 141:321-32. 2006
    The present study evaluated a moderational model of neuroticism on the relation between smoking level and panic disorder using data from the National Comorbidity Survey...
  58. ncbi The emotional Stroop: a comparison of panic disorder patients, obsessive-compulsive patients, and normal controls, in two experiments
    Mirjam Kampman
    Department of Clinical Psychology, University of Nijmegen, The Netherlands
    J Anxiety Disord 16:425-41. 2002
    ..The first experiment involved 21 panic disorder (PD) patients and 20 normal controls; the second experiment 20 PD patients and 20 obsessive-compulsive ..
  59. ncbi Transdiagnostic Internet treatment for anxiety disorders: A randomized controlled trial
    Nickolai Titov
    University of New South Wales, Sydney, Australia
    Behav Res Ther 48:890-9. 2010
    ..Eighty six individuals meeting diagnostic criteria for generalized anxiety disorder (GAD), panic disorder, and/or social phobia were randomly assigned to a treatment group, or to a waitlist control group...
  60. pmc Automatic associations and panic disorder: trajectories of change over the course of treatment
    Bethany A Teachman
    Department of Psychology, University of Virginia, Charlottesville, VA 22904 4400, USA
    J Consult Clin Psychol 76:988-1002. 2008
    ..Individuals with panic disorder (N = 43) completed a measure of automatic panic associations--the Implicit Association Test (A. G...
  61. ncbi A striking pattern of cortisol non-responsiveness to psychosocial stress in patients with panic disorder with concurrent normal cortisol awakening responses
    Katja Petrowski
    Institute of Psychotherapy and Psychosomatic Medicine, School of Medicine, Technische Universitat Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Psychoneuroendocrinology 35:414-21. 2010
    ..differences in hypothalamic-pituitary-adrenal (HPA) axis activity have been reported for patients with panic disorder. While these patients show little or no alterations in basal ACTH and cortisol levels, it has been ..
  62. ncbi The separation anxiety hypothesis of panic disorder revisited: a meta-analysis
    Joe Kossowsky
    Department of Clinical Psychology and Psychotherapy, University of Basel, Switzerland
    Am J Psychiatry 170:768-81. 2013
    ..The authors conducted a meta-analysis to examine the relationship between childhood separation anxiety disorder and future psychopathology...
  63. ncbi Impact of panic disorder upon self-management educational goals in chronic obstructive pulmonary disease?
    Claire A Dowson
    Department of Public Health and General Practice, University of Otago, Christchurch, New Zealand
    Chron Respir Dis 7:83-90. 2010
    ..This study's aim was to investigate whether people with panic disorder (PD), compared to non-panic-disordered (NPD), derived additional educational or psychological benefits from ..
  64. ncbi Interstitial cystitis and panic disorder: a potential genetic syndrome
    Myrna M Weissman
    Departments of Psychiatry and Urology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Arch Gen Psychiatry 61:273-9. 2004
    Evidence from a genetic linkage study had suggested a possible syndrome in some families with panic disorder (PD)...
  65. ncbi Cognitive modulation of the endocrine stress response to a pharmacological challenge in normal and panic disorder subjects
    James L Abelson
    Department of Psychiatry and Mental Health Research Institute, Trauma, Stress and Anxiety Research Group, University of Michigan, Ann Arbor 48109 0118, USA
    Arch Gen Psychiatry 62:668-75. 2005
    ..Scientific study of how such factors moderate human HPA axis activity has been limited. Their relevance to HPA axis disturbances in psychiatric patients is largely unexplored...
  66. ncbi The acute antipanic activity of aerobic exercise
    Andreas Strohle
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite University Medicine Berlin, Schumannstr 20 21, 10117 Berlin, Germany
    Am J Psychiatry 162:2376-8. 2005
    Regular physical activity is anxiolytic for both healthy subjects and patients with panic disorder. However, the acute antipanic activity of exercise has not yet been studied systematically.
  67. ncbi Gray matter deficits in panic disorder: a pilot study of meta-analysis
    Chien Han Lai
    Department of Psychiatry, Buddhist Tzu Chi General Hospital, Taipei Branch, National Yang Ming University, Taipei, Taiwan
    J Clin Psychopharmacol 31:287-93. 2011
    This study aimed to conduct a meta-analysis of published voxel-based morphometry studies in panic disorder (PD).
  68. ncbi Nitric oxide, adenosine deaminase, xanthine oxidase and superoxide dismutase in patients with panic disorder: alterations by antidepressant treatment
    Hasan Herken
    Department of Psychiatry, Medical Faculty of Gaziantep University, Turkey
    Hum Psychopharmacol 21:53-9. 2006
    ..levels and activities of xanthine oxidase (XO), superoxide dismutase (SOD), and adenosine deaminase (ADA) are associated with Panic disorder (PD) as well as impact of psychopharmacological treatments on NO, SOD, ADA, and XO levels in PD.
  69. pmc Meta-analysis of genome-wide association studies for panic disorder in the Japanese population
    T Otowa
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Transl Psychiatry 2:e186. 2012
    b>Panic disorder (PD) is a moderately heritable anxiety disorder whose pathogenesis is not well understood. Due to the lack of power in previous association studies, genes that are truly associated with PD might not be detected...
  70. ncbi The impact of smoking on panic disorder: an initial investigation of a pathoplastic relationship
    Michael J Zvolensky
    Department of Psychology, The University of Vermont, John Dewey Hall, Burlington, VT 05405 0134, USA
    J Anxiety Disord 17:447-60. 2003
    A disproportionate number of persons with panic disorder (PD) smoke cigarettes compared to individuals with other anxiety disorders and people in the general population...
  71. ncbi The impact of personality disorders on treatment outcome of anxiety disorders: best-evidence synthesis
    L Dreessen
    Department of Medical Psychology, Maastricht University, The Netherlands
    Behav Res Ther 36:483-504. 1998
    ..For the time being, in clinical practice one has to be cautious in relating personality disorders to less well treatment outcome in axis I anxiety disorders...
  72. ncbi Heritability of anxiety sensitivity: a twin study
    M B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
    Am J Psychiatry 156:246-51. 1999
    In attempting to explain the familial predisposition to panic disorder, most studies have focused on the heritability of physiologic characteristics (e.g., CO2 sensitivity)...
  73. ncbi Revise the revised? New dimensions of the neuroanatomical hypothesis of panic disorder
    Thomas Dresler
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Calwerstr 14, 72076, Tubingen, Germany
    J Neural Transm 120:3-29. 2013
    ..published a widely acknowledged revised version of their 1989 neuroanatomical hypothesis of panic disorder (PD)...
  74. ncbi Fronto-occipital fasciculus, corpus callosum and superior longitudinal fasciculus tract alterations of first-episode, medication-naïve and late-onset panic disorder patients
    Chien Han Lai
    Department of Psychiatry, Cheng Hsin General Hospital, Taipei City, Taiwan, ROC
    J Affect Disord 146:378-82. 2013
    Because of limited knowledge about white matter (WM) tract in panic disorder, we designed this study to investigate alterations of WM tracts in first-episode medication-naïve panic disorder patients.
  75. ncbi Self-exposure therapy for panic disorder with agoraphobia: randomised controlled study of external v. interoceptive self-exposure
    L M Ito
    Institute of Psychiatry, , CEP 05403-010, , Brazil
    Br J Psychiatry 178:331-6. 2001
    ..CONCLUSIONS: The three methods of self-exposure were equally effective in reducing panic and agoraphobic symptoms in the short- and long-term...
  76. ncbi Covariation bias and its physiological correlates in panic disorder patients
    Christine Amrhein
    Clinic for Psychiatric Medicine and Psychotherapy, University Hospital of Tubingen, Tubingen, Germany
    J Anxiety Disord 19:177-91. 2005
    ..CNV presumably reflects a biased processing of disorder-relevant stimuli by panic patients, perhaps with the expectation that aversive consequences will follow these stimuli...
  77. ncbi Prognostic indices with brief and standard CBT for panic disorder: I. Predictors of outcome
    Michael G T Dow
    NHS Fife, Department of Clinical Psychology, Stratheden Hospital, Cupar, Fife, UK
    Psychol Med 37:1493-502. 2007
    Although the effectiveness of cognitive behavioural therapy (CBT) in the management of panic disorder (PD) is now well established, there have been few studies of predictors of outcome with this patient group using clinical effectiveness ..
  78. ncbi An expanded anxiety sensitivity index: evidence for a hierarchic structure in a clinical sample
    S Taylor
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Anxiety Disord 12:463-83. 1998
    ..reactions, and plays an important role in the etiology and maintenance of anxiety disorders, particularly panic disorder. Recent evidence suggests that AS has a hierarchical structure, consisting of multiple lower order factors, ..
  79. ncbi Effect of gender on processing threat-related stimuli in patients with panic disorder: sex does matter
    Patricia Ohrmann
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Depress Anxiety 27:1034-43. 2010
    ..g. panic disorder (PD).
  80. ncbi Posterior orbitofrontal sulcogyral pattern associated with orbitofrontal cortex volume reduction and anxiety trait in panic disorder
    Tomohide Roppongi
    Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan
    Psychiatry Clin Neurosci 64:318-26. 2010
    ..The purpose of the present study was to assess the relationship between posterior OFC sulcogyral pattern and OFC volume difference in patients with panic disorder.
  81. ncbi Neuropsychological deficits in obsessive-compulsive disorder: a comparison with unipolar depression, panic disorder, and normal controls
    R Purcell
    Department of Psychology, The University of Melbourne, Royal Melbourne Hospital, Australia
    Arch Gen Psychiatry 55:415-23. 1998
    ..We directly compared cognitive function in patients with OCD with that in matched patients with unipolar depression and panic disorder and healthy control subjects to establish the specific nature of neuropsychological deficits in OCD.
  82. ncbi A randomized, controlled trial of aerobic exercise in combination with paroxetine in the treatment of panic disorder
    Dirk Wedekind
    Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
    World J Biol Psychiatry 11:904-13. 2010
    Regular aerobic exercise (running) has been shown to be superior to a pill placebo in the treatment of panic disorder. Combined drug and exercise treatment has not been investigated in randomized controlled studies to date.
  83. ncbi Sympathetic nervous function and the effect of the catechol-O-methyltransferase Val(158)Met polymorphism in patients with panic disorder
    Eun Ho Kang
    Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    J Affect Disord 123:337-40. 2010
    Sympathetic nervous function abnormalities have long been suggested to be a possible etiology of panic disorder (PD)...
  84. ncbi Patterns of psychopathology and dysfunction in high-risk children of parents with panic disorder and major depression
    J Biederman
    Pediatric Psychopharmacology Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 158:49-57. 2001
    ..by all anxiety disorders or whether specific risks are associated with specific disorders, and 2) whether panic disorder and major depression have a familial link...
  85. ncbi Fear conditioning in panic disorder: Enhanced resistance to extinction
    Tanja Michael
    Department of Clinical Psychology and Psychotherapy, Institute for Psychology, University of Basel, Basel, Switzerland
    J Abnorm Psychol 116:612-7. 2007
    Enhanced conditionability has been proposed as a crucial factor in the etiology and maintenance of panic disorder (PD)...
  86. ncbi Association between joint hypermobility syndrome and panic disorder: a case-control study
    Javier Garcia Campayo
    Dept of Psychiatry, Miguel Servet University Hospital, University of Zaragoza, Zaragoza, Spain
    Psychosomatics 51:55-61. 2010
    A significant association between joint hypermobility syndrome (JHS) and panic disorder was observed in a sample of rheumatology outpatients.
  87. pmc Vestibular testing in patients with panic disorder and chronic dizziness
    R Teggi
    ENT Department, IRRCS San Raffaele Hospital, Vita Salute University, Milan, Italy
    Acta Otorhinolaryngol Ital 27:243-7. 2007
    In order to investigate the relationship between chronic dizziness and vestibular function in patients with panic disorder, in the present study neurotologic findings in 15 patients with panic disorder and chronic dizziness were compared ..
  88. ncbi Psychometric properties of the panic disorder severity scale: clinician-administered and self-report versions
    Lisa A Wuyek
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Clin Psychol Psychother 18:234-43. 2011
    The Panic Disorder Severity Scale (PDSS) is a seven-item scale designed to assess overall severity of panic disorder symptoms...
  89. ncbi Changes of brain activation pre- post short-term psychodynamic inpatient psychotherapy: an fMRI study of panic disorder patients
    Manfred E Beutel
    Clinic for Psychosomatic Medicine and Psychotherapy, University Medicine, Mainz, Germany
    Psychiatry Res 184:96-104. 2010
    ..functional magnetic resonance imaging (fMRI) design to determine changes of brain activation patterns of panic disorder (PD) patients following short-term psychodynamic inpatient treatment...
  90. ncbi Childhood history of anxiety disorders among adults with social phobia: rates, correlates, and comparisons with patients with panic disorder
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Depress Anxiety 14:209-13. 2001
    ..childhood anxiety disorders were evaluated to diagnostic comorbidity and a comparison group of patients with panic disorder. Onset of social phobia occurred before age 18 in 80% of the sample...
  91. ncbi Physiologic instability in panic disorder and generalized anxiety disorder
    F H Wilhelm
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA
    Biol Psychiatry 49:596-605. 2001
    Because panic attacks can be accompanied by surges in physiologic activation, we tested the hypothesis that panic disorder is characterized by fluctuations of physiologic variables in the absence of external triggers.
  92. ncbi Acute exercise reduces the effects of a 35% CO2 challenge in patients with panic disorder
    Gabriel Esquivel
    Academic Anxiety Center, Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    J Affect Disord 107:217-20. 2008
    Chronic exercise has been shown to have therapeutic effects in panic disorder (PD). The mechanism of these effects is unknown. Acute exercise reduces the effect of a panic challenge in healthy volunteers...
  93. ncbi Relationship between alexithymia and panic disorder: a longitudinal study to answer an open question
    Carlo Marchesi
    Department of Neuroscience, Psychiatric Clinic, University of Parma, Str del Quartiere 2, IT 43100 Parma, Italy
    Psychother Psychosom 74:56-60. 2005
    In the present study, we evaluated whether patients with panic disorder (PD) in complete remission were more alexithymic than normal controls.
  94. ncbi The association between panic disorder and the L/L genotype of catechol-O-methyltransferase
    Jong Min Woo
    Department of Neuropsychiatry, Inje University Seoul Paik Hospital, Seoul, Republic of Korea
    J Psychiatr Res 38:365-70. 2004
    To clarify the role of catechol-O-methyltransferase (COMT) polymorphism in panic disorder (PD), we investigated a large group of Korean PD patients (N = 178) and controls (N = 182) using a case-control study...
  95. ncbi Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia
    M Boldrini
    Department of Neuroscience, New York State Psychiatric Institute New York, NY, USA
    Acta Psychiatr Scand 111:150-8. 2005
    ..We investigated their specificity comparing cognitive function in OCD, panic disorder with agoraphobia (PD/A) and controls by a comprehensive neuropsychological battery.
  96. ncbi (1)H magnetic resonance spectroscopy imaging of the hippocampus in patients with panic disorder
    Clarissa Trzesniak
    Department of Neuroscience and Behavior, Division of Psychiatry, Faculty of Medicine, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Psychiatry Res 182:261-5. 2010
    Recent theories of panic disorder propose an extensive involvement of limbic system structures, such as the hippocampus, in the pathophysiology of this condition...
  97. pmc Single-unit analysis of sympathetic nervous discharges in patients with panic disorder
    Elisabeth Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, PO Box 6492 St Kilda Road Central, Melbourne, Victoria, Australia
    J Physiol 570:637-43. 2006
    Patients with panic disorder are at increased cardiac risk. While the mechanisms responsible remain unknown, activation of the sympathetic nervous system may be implicated...
  98. ncbi Anxiety sensitivity and panic disorder
    Richard J McNally
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Biol Psychiatry 52:938-46. 2002
    ..Sensitivity Index (ASI), anxiety sensitivity is a dispositional variable especially elevated in people with panic disorder. Regardless of diagnosis, ASI scores often predict panic symptoms in response to biological challenges (e.g...
  99. pmc A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene
    Noomi Gregersen
    Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Aarhus, Denmark
    Eur J Hum Genet 20:84-90. 2012
    b>Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD...
  100. ncbi The incidence and influence of early traumatic life events in patients with panic disorder: a comparison with other psychiatric outpatients
    Steven Friedman
    Department of Psychiatry, State University of New York Health Science Center at Brooklyn, NY 11203, USA
    J Anxiety Disord 16:259-72. 2002
    ..life events, including childhood physical and sexual abuse, has been associated with increased risk for panic disorder in adulthood...
  101. ncbi Panic attacks as a risk for later psychopathology: results from a nationally representative survey
    D Jolene Kinley
    Department of Psychology, University of Manitoba, Winnipeg, MB, Canada
    Depress Anxiety 28:412-9. 2011
    There is a growing body of literature suggesting that panic attacks without panic disorder are associated with increases in a wide range of psychopathology and impairment...

Research Grants64

  1. Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep Disru
    PHILIP LEE JOHNSON; Fiscal Year: 2013
    ..was that a hypothalamic orexin system plays a critical role panic vulnerability in an accepted rat model of panic disorder and that central orexin levels are elevated in patients with panic disorder...
  2. Conference on Autonomic Regulation of Cardiovascular Function in Health and Disea
    Martin Frank; Fiscal Year: 2012
    ..At least 1 symposium and several talks will be dedicated to sympathetic regulation in humans. These talks will include heart failure, hypertension, POTS, panic disorder and obesity/metabolic syndrome.
  3. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..Alterations in GABAA function from controls are known to occur in many anxiety disorders including panic disorder, epilepsy, hypersensitive behavior, phobias, schizophrenia, alcoholism, Anglemans syndrome and Rhetts syndrome,..
  4. Integrated PTSD and Smoking Treatment
    Mark B Powers; Fiscal Year: 2013
    ..Anxiety sensitivity is higher in persons with PTSD than in any other anxiety disorder except for panic disorder.9 High anxiety sensitivity is uniquely associated with greater odds of lapse10 and relapse11-13 during quit ..
  5. Anxiety Sensitivity, Menstrual Cycle Phase, and Panic-Relevant Responding
    Yael Nillni; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The prevalence of panic disorder, a debilitating mental health problem characterized by recurrent, unexpected panic attacks, is 2 times higher among females relative to males...
  6. Neurobiology of Anxiety and Panic Disorders
    Anantha Shekhar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Panic disorder (PD) is a severe anxiety disorder characterized by recurrent panic attacks affecting about 2- 5% of the population and resulting in severe disability in about a third of those subjects...
  7. ORGANIZATION OF PREFRONTAL FEEDBACK CIRCUITS
    Helen Barbas; Fiscal Year: 2013
    ..disrupted in several psychiatric diseases characterized by anxiety, including post-traumatic stress disorder, panic disorder, obsessive-compulsive disorder and depression, affecting the systems under study...
  8. Neuropeptide circuits and stress regulation in the basolateral amygdala
    JANICE URBAN; Fiscal Year: 2009
    ..the individual resulting in continued anxiety which can manifest as anxiety-related stress disorders such as panic disorder, posttraumatic stress disorder (PTSD) or depression...
  9. Adaptation of a Behavioral Treatment for Latinos with Panic Disorder and Asthma
    Jonathan M Feldman; Fiscal Year: 2012
    ..This is a pilot study designed to culturally adapt for Latinos a behavioral treatment for comorbid panic disorder (PD) and asthma, and examine its efficacy versus an active placebo treatment...
  10. A Cognitive-Behavioral Intervention for Anxiety in Parkinson's Disease
    GRETCHEN OLSON REYNOLDS; Fiscal Year: 2013
    ..that anxious PD patients will present mainly with generalized anxiety disorder, social anxiety disorder, or panic disorder and that the anxiety symptoms will not be solely a reaction to the motor symptoms of PD...
  11. Oxytocin regulation of social buffering following stress
    ADAM STEVEN SMITH; Fiscal Year: 2012
    ..of the hypothalamic-pituitary-adrenal (HPA) axis, and reduce the odds of psychological distress or a panic disorder;this is known as social buffering. This is particularly true when support is derived from a social partner (e...
  12. Upstream control and downstream effects of NPS release
    Olivier Civelli; Fiscal Year: 2013
    ..A naturally occurring mutation in the NPS receptor gene is associated with panic disorder, making the NPS system an interesting candidate for development of new drugs that could have therapeutic ..
  13. Molecular Mechanisms of Social Behavior
    Anna V Kukekova; Fiscal Year: 2010
    ..and primates in biological complexity, would then offer opportunities to investigate potential therapies for such human disorders as autism, schizophrenia, anxiety, depression, personality disorders, panic disorder and other traits.
  14. Genetics of Anxiety Disorders
    Joel Gelernter; Fiscal Year: 2013
    ..goal of the proposed project is to identify genes influencing susceptibility for anxiety disorders, especially panic disorder (PD) and social phobia (SocP), and anxiety traits...
  15. Behavior-based chemical screening for GABAergic and startle modifying drugs
    David Kokel; Fiscal Year: 2013
    ..Anxiety disorders such as generalized anxiety disorder, panic disorder and post-traumatic stress disorder are widespread and devastating illnesses...
  16. Endogenous Opioid System in Panic Disorder: 5-Dose Naloxone Procedure and SSRI Tx
    Smit S Sinha; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Panic disorder (PD) is a severe and debilitating anxiety disorder. Despite extensive research, the neurobiology of PD remains poorly understood...
  17. Patterns and mediators of emotion regulatory disturbance in panic disorder
    Casey Sarapas; Fiscal Year: 2013
    ..project that will use psychophysiological measures to investigate emotion regulatory (ER) disturbance in Panic Disorder (PD) and examine possible cognitive mechanisms of this disturbance...
  18. Computerized Intervention for Anxiety Sensitivity Cognitive Concerns
    Daniel W Capron; Fiscal Year: 2013
    ..associated with depression, whereas, AS physical concerns are more associated with anxiety conditions such as panic disorder. Second, individuals with elevated ASCC show elevated SI, whereas individuals with elevated AS physical ..
  19. MULTIDIMENSIONAL HORMONAL ASSESSMENT OF PTSD
    Sheila Wang; Fiscal Year: 1999
    ..SCID data on 160 West Haven VA veterans with PTSD to assess the status of comorbid diagnoses, including Panic Disorder, Major Depressive Disorder, and several categories of Substance Abuse, as potential confounding variables, in ..
  20. Revealing fear: new methods to study neural circuits, behavior and disease
    Sandeep R Datta; Fiscal Year: 2010
    ..In addition to its direct relevance to anxiety and panic disorder, this circuit will serve as an invaluable platform for testing theories about sensory coding, learning and ..
  21. 1/3-Exposure D-Cycloserine Enhancement and Genetic Modulators in Panic Disorder
    Michael W Otto; Fiscal Year: 2012
    ..augmenting the effects of exposure- based cognitive-behavior therapy (CBT), now applied to the treatment of panic disorder with or without agoraphobia...
  22. Orexin receptor antagonists for drug addiction and panic disorder
    Paul J Kenny; Fiscal Year: 2013
    ..Hence, this program promises to yield OX1 receptor antagonists as novel therapeutic for smoking cessation. ..
  23. Neural Probes of Respiratory Control and Interoception in Panic Disorder
    Karleyton C Evans; Fiscal Year: 2013
    Neural Probes of Respiratory Control and Interoception in Panic Disorder," an application for an NIMH Patient Oriented Research Caree r Development Award (K23)...
  24. Ambulatory_Physiological_Monitor_for_Posttraumatic_Stress_Disorder
    MARK BLY; Fiscal Year: 2013
    ..the device such as the routine screening, monitoring, and treatment of PTSD or other mental health disorders and conditions, including panic disorder, phobias, generalized anxiety disorder, depressive disorders, and overall life stress.
  25. Role of Serotonin and CRF Pathways in Anxiety and HPA Regulations
    Anantha Shekhar; Fiscal Year: 2013
    ..Our hypothesis for the present proposal will focus on two types of severe anxiety disorders, panic disorder (PD) and social anxiety disorder (SAD)...
  26. Web Based Therapist Training on Cognitive Behavior Therapy for Anxiety Disorders
    Kenneth Kobak; Fiscal Year: 2010
    ..g., Obsessive Compulsive Disorder, panic disorder, Generalized Anxiety Disorder, Posttraumatic Stress Disorder) and a full evaluation of the efficacy of the ..
  27. Genetic and Pathophysiologic Investigation of Panic Disorder Typologies
    Roxann Roberson-Nay; Fiscal Year: 2012
    ..proposes to provide advanced research training in psychiatric and molecular genetics with a research focus on panic disorder (PD). Dr. Kenneth S. Kendler, M.D., a world renowned researcher in psychiatric genetics, will serve as Dr...
  28. 3/3-Exposure D-Cycloserine Enhancement and Genetic Modulators in Panic Disorder
    Mark H Pollack; Fiscal Year: 2012
    ..augmenting the effects of exposure- based cognitive-behavior therapy (CBT), now applied to the treatment of panic disorder with or without agoraphobia...
  29. Neural Mechanisms of Fear Extinction Across Anxiety Disorders
    Mohammed R Milad; Fiscal Year: 2013
    ..diagnosed with social anxiety disorder (SAD), generalized anxiety disorders (GAD), specific phobia (SP), and panic disorder (PD) will undergo the fear conditioning and extinction paradigm while in a 3T fMRI scanner...
  30. Web Based Therapist Training on Cognitive Behavior Therapy for Anxiety Disorders
    Kenneth Kobak; Fiscal Year: 2013
    ..e., Obsessive Compulsive Disorder, Panic Disorder, Generalized Anxiety Disorder, Posttraumatic Stress Disorder and Social Anxiety Disorder)...
  31. From Fear to Anxious Misery: Developing a Defense Circuit Dimensional Classifier
    Peter J Lang; Fiscal Year: 2013
    ..g, panic disorder, generalized anxiety disorder) characteristically show blunted reflex responses...
  32. Online PCT Training for Clinicians
    MELANIE HARNED; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Panic attacks (PA) impact about 23% of adults in community samples. Panic disorder with or without agoraphobia (PDA) tends to be a chronic condition with a lifetime prevalence of 4.7%...
  33. Panic Disorder and Nicotine Withdrawal
    TERESA MARIA LEYRO; Fiscal Year: 2010
    ..among daily smokers results in greater fearful responding to induced bodily sensations among those with Panic Disorder (PD), as compared to those without PD...
  34. Transdiagnostic Preventative Intervention for Subclinical Anxiety
    KRISTINA JO KORTE; Fiscal Year: 2013
    ..panic attacks). Although these interventions are effective at reducing risk for the targeted disorder (e.g., panic disorder), the focus of the intervention is narrow, thereby limiting the dissemination of these interventions...
  35. Online Training in the Principles and Procedures of Exposure Therapies
    MELANIE HARNED; Fiscal Year: 2010
    ..g., Panic Control Treatment for panic disorder). Additionally, subjects will complete two application based measures, including a performance-based role play...
  36. Response to Unpredictable Threat in Alcohol Dependence and Panic Disorder
    STEPHANIE GORKA; Fiscal Year: 2013
    ..with the proposed study of psychophysiological processes underlying comorbid alcohol dependence (AD) and panic disorder (PD)...
  37. Amygdala Priming Mechanism Underlying the Panic Response
    SHELLEY THIELEN; Fiscal Year: 2001
    Anxiety disorders are the most common of all mental health illnesses. Panic disorder (PD), a DSM recognized anxiety disorder, has a lifetime prevalence of 3.5%...
  38. Acid-sensing and Panic
    Renu Sah; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Panic Disorder (PD) is a common psychiatric illness that afflicts approximately 6 million people annually in the US. Despite considerable research, the neurobiological basis of PD is poorly understood...
  39. CCK MODULATION OF ANXIETY AND THE HPA AXIS
    James Abelson; Fiscal Year: 1999
    ..CCK may play a pathophysiological role in panic disorder--which is a common, disabling disorder with high social morbidity costs...
  40. Role of novel pH-sensing receptor TDAG8 in panic
    Renu Sah; Fiscal Year: 2009
    b>Panic Disorder (PD) is a common psychiatric illness that afflicts approximately 6 million people annually in the US. Despite considerable research, the neurobiological basis of PD is poorly understood...
  41. Role of Amygdalar CRF Receptors in Regulating Anxiety
    Tammy Sajdyk; Fiscal Year: 2005
    ..will produce a long-term facilitation of the anxiety responses resembling a subtype of pathological anxiety, panic disorder. The behavioral paradigms utilized to measure anxiety for each set of experiments will be the social ..
  42. DRUG TREATMENT OF COEXISTING PANIC AND MAJOR DEPRESSION
    ROBERT LYDIARD; Fiscal Year: 1999
    b>Panic disorder and major depression are both serious illnesses which are associated with severe and disabling symptoms often including extreme difficulty functioning at work and at home as well as a high risk of suicide attempts and ..
  43. HPA Axis in Depression and Anxiety
    Elizabeth Young; Fiscal Year: 2005
    ..will continue to explore hormonal abnormalities in depression and also in related anxiety disorders, panic disorder and PTSD...
  44. Comorbid Anxiety Disorders in Adolescents with Asthma
    Wayne Katon; Fiscal Year: 2006
    ..Results from prior studies have suggested an increased prevalence of panic disorder and other anxiety disorders in populations of children and adults with asthma...
  45. ADRENERGIC VARIABLES: STATE MARKERS FOR PANIC DISORDER
    Oliver Cameron; Fiscal Year: 1990
    Patients with panic disorder have decreased platelet alpha 2 adrenoreceptors and increased adrenergic reactivity...
  46. Pattern Analysis of Large-Scale Functional Connectivity in SAD
    SPIRO PETER PANTAZATOS; Fiscal Year: 2012
    ..emotion perception to aid the diagnosis and assessment of treatment response in social anxiety (SAD) and panic disorder (PD). The following Specific Aims are proposed: Specific Aim 1)...
  47. Dynamic Therapy Vs. CBT for Panic Disorder
    Jacques P Barber; Fiscal Year: 2010
    b>Panic disorder (PD) is a prevalent and debilitating condition. Efficacious treatments for this condition exist, including several classes of medication. Cognitive behavioral therapy, (CBT) has been shown to be efficacious for PD...
  48. Dynamic Therapy Vs. CBT for Panic Disorder
    Barbara L Milrod; Fiscal Year: 2012
    b>Panic disorder (PD) is a prevalent and debilitating condition. Efficacious treatments for this condition exist, including several classes of medication. Cognitive behavioral therapy, (CBT) has been shown to be efficacious for PD...
  49. CBT Treatment of Panic Disorder in Comorbid Alcoholics
    MATT KUSHNER; Fiscal Year: 2003
    ..in finding an increased risk of alcohol use disorder among those suffering with the anxiety syndrome, panic disorder "comorbidity"...
  50. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Scott Woods; Fiscal Year: 2003
    ..broad goals underlie this continuation application for a multicenter collaborative study of the treatment of panic disorder: 1) completion of the originally proposed study, comparing cognitive behavioral panic control treatment (PCT), ..
  51. Interactive Computer Treatment for Panic Disorder
    NORMAN SCHMIDT; Fiscal Year: 2004
    ..b>Panic disorder (PD) is a highly prevalent and debilitating condition...
  52. GABA NEURONAL DYSFUNCTION IN PANIC DISORDER
    Andrew Goddard; Fiscal Year: 2000
    ..augment GABA function such as the BZDs and valproic acid, are known to be effective clinical treatments for panic disorder (PD). In addition, other effective antipanic medications, imipramine and phenelzine, increase brain GABA...
  53. IDENTIFICATION AND CHARACTERIZATION OF LATE LIFE PANIC
    William Apfeldorf; Fiscal Year: 2001
    ..The specific aims of the research plan are: 1) to describe the expression and course of late life panic disorder, and its impact on medical morbidity and functioning in elderly panic disorder patients and elderly normal ..
  54. GENETIC STUDIES OF DEPRESSIVE DISORDERS
    Myrna Weissman; Fiscal Year: 2001
    ..understanding of the etiology, heterogeneity and comorbidity of major depression (MDD) and its relationship to panic disorder. This last renewal focused efforts on two subtypes of depression (MDD with onset before age 30 and MDD with ..
  55. VALIDATION STUDY OF PANIC DISORDER IN CHILDREN
    Donna Moreau; Fiscal Year: 1992
    This is an application to identify and intensively study panic attacks and panic disorder in children and adolescents who present to pediatric emergency rooms, pediatric clinical services and psychiatric services...
  56. LINKAGE STUDY OF PANIC DISORDER
    Raymond Crowe; Fiscal Year: 1999
    Background: Family and twin studies indicate that panic disorder is a genetic disease. These data indicate that the genes could act either independently, by either a dominant or a recessive model, or additively...
  57. COGNITION AND PANIC
    Richard McNally; Fiscal Year: 1991
    Psychopathologists have increasingly emphasized the need for more research on the cognitive aspects of panic disorder. Unfortunately, most cognitive research has relied solely on patient self-report as the sole measure of cognition...
  58. VENTILATORY PHYSIOLOGY IN CHILDREN AT RISK FOR ANXIETY
    Rachel Klein; Fiscal Year: 2002
    ..The study specifically evolves from findings that link childhood separation anxiety disorder (SAD) and adult panic disorder (PD)...
  59. FOCUSED COGNITIVE THERAPY FOR PANIC DISORDER
    Aaron Beck; Fiscal Year: 1990
    ..efficacy of focal cognitive therapy (FCT) to standard cognitive therapy for anxiety (SCT) for the treatment of panic disorder. In addition, the effectiveness of both approaches in helping medicated patients to discontinue ..
  60. BIOLOGY OF COMORBID DEPRESSION AND ANXIETY
    Elizabeth Young; Fiscal Year: 2001
    ..that depression is accompanied by abnormalities of the HPA axis, while anxiety disorders, particularly panic disorder, is accompanied by abnormalities of the central NA system, as reflected by a blunted growth hormone (GH) ..
  61. Information Processing and Treatment for Panic Disorder
    Bethany Teachman; Fiscal Year: 2006
    ..This proposal seeks to examine relationships among information processing measures in panic disorder, and to examine the patterns of change in cognitive and symptom measures over the course of treatment to ..
  62. BENZODIAZEPINE SENSITIVITY IN HUMAN ANXIETY
    Peter Roy Byrne; Fiscal Year: 1993
    ..states of anxiety, our original study examined sensitivity to successive injections of IV diazepam in panic disorder patients and controls, using saccadic eye velocity as the major pharmacodynamic measure...
  63. TREATMENTS FOR ANXIETY
    David Barlow; Fiscal Year: 1992
    The continuing objectives of this project is to develop effective psychosocial treatments for panic disorder and generalized anxiety disorder...