obsessive compulsive disorder

Summary

Summary: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.

Top Publications

  1. ncbi Increased nocturnal secretion of ACTH and cortisol in obsessive compulsive disorder
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 41:928-33. 2007
  2. ncbi Sleep onset REM periods in obsessive compulsive disorder
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychiatry Res 152:29-35. 2007
  3. pmc Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited
    Lara Menzies
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neurosci Biobehav Rev 32:525-49. 2008
  4. ncbi Frontal-striatal dysfunction during planning in obsessive-compulsive disorder
    Odile A van den Heuvel
    Departments of Psychiatry, Anatomy, and Radiology and Outpatient Clinic for Anxiety Disorders, GGZ Buitenamstel, VU University Medical Center, Amsterdam, The Netherlands
    Arch Gen Psychiatry 62:301-9. 2005
  5. ncbi Neurocognitive endophenotypes of obsessive-compulsive disorder
    Lara Menzies
    Brain Mapping Unit, University of Cambridge, Cambridge, UK
    Brain 130:3223-36. 2007
  6. ncbi Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder
    David Mataix-Cols
    Department of Psychological Medicine, Institute of Psychiatry, London, England
    Arch Gen Psychiatry 61:564-76. 2004
  7. ncbi A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Neuropsychologia 45:654-62. 2007
  8. ncbi The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems
    Odile A van den Heuvel
    Department of Psychiatry, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Brain 132:853-68. 2009
  9. ncbi A multidimensional model of obsessive-compulsive disorder
    David Mataix-Cols
    Institute of Psychiatry, London
    Am J Psychiatry 162:228-38. 2005
  10. ncbi Quality of life in obsessive-compulsive disorder before and after treatment
    Steffen Moritz
    Department of Psychiatry and Psychotherapy, University Hospital of Hamburg, Germany
    Compr Psychiatry 46:453-9. 2005

Detail Information

Publications358 found, 100 shown here

  1. ncbi Increased nocturnal secretion of ACTH and cortisol in obsessive compulsive disorder
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 41:928-33. 2007
    ..of the hypothalamic-pituitary-adrenal (HPA) axis, the main mammalian system of stress response, in obsessive compulsive disorder (OCD) is inconsistent...
  2. ncbi Sleep onset REM periods in obsessive compulsive disorder
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychiatry Res 152:29-35. 2007
    Sleep studies in patients with obsessive compulsive disorder (OCD) are sparse and results inconsistent. Moreover, in 3 out of 4 published studies up to 50% of patients suffered from secondary major depression...
  3. pmc Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited
    Lara Menzies
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neurosci Biobehav Rev 32:525-49. 2008
    ....
  4. ncbi Frontal-striatal dysfunction during planning in obsessive-compulsive disorder
    Odile A van den Heuvel
    Departments of Psychiatry, Anatomy, and Radiology and Outpatient Clinic for Anxiety Disorders, GGZ Buitenamstel, VU University Medical Center, Amsterdam, The Netherlands
    Arch Gen Psychiatry 62:301-9. 2005
    ..In addition, neuropsychological studies in OCD have reported impairments in visuospatial tasks and executive functions, such as planning...
  5. ncbi Neurocognitive endophenotypes of obsessive-compulsive disorder
    Lara Menzies
    Brain Mapping Unit, University of Cambridge, Cambridge, UK
    Brain 130:3223-36. 2007
    ..In summary, structural variation in large-scale brain systems related to motor inhibitory control may mediate genetic risk for OCD, representing the first evidence for a neurocognitive endophenotype of OCD...
  6. ncbi Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder
    David Mataix-Cols
    Department of Psychological Medicine, Institute of Psychiatry, London, England
    Arch Gen Psychiatry 61:564-76. 2004
    ....
  7. ncbi A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Neuropsychologia 45:654-62. 2007
    ..However, the extent to which these disorders share a common cognitive phenotype has yet to be elucidated using patients without confounding co-morbidities...
  8. ncbi The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems
    Odile A van den Heuvel
    Department of Psychiatry, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Brain 132:853-68. 2009
    ..These results have clear implications for the current neuroanatomical model of OCD and call for a substantial revision of such model which takes into account the heterogeneity of the disorder...
  9. ncbi A multidimensional model of obsessive-compulsive disorder
    David Mataix-Cols
    Institute of Psychiatry, London
    Am J Psychiatry 162:228-38. 2005
    ..This heterogeneity can reduce the power and obscure the findings from natural history studies to genome scans, neuroimaging, and clinical trials. The authors review the evidence supporting a multidimensional model of OCD...
  10. ncbi Quality of life in obsessive-compulsive disorder before and after treatment
    Steffen Moritz
    Department of Psychiatry and Psychotherapy, University Hospital of Hamburg, Germany
    Compr Psychiatry 46:453-9. 2005
    ..In line with prior research, it was expected that low QoL in OCD patients would be most pronounced for the emotional and social aspects of the construct...
  11. ncbi Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders
    Margarita Muiños-Gimeno
    Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública CIBERESP, Barcelona, Spain
    Hum Mutat 30:1062-71. 2009
    ..These data implicate miRNAs as key posttranscriptional regulators of NTRK3 and provide a framework for allele-specific miRNA regulation of NTRK3 in anxiety disorders...
  12. ncbi Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder
    Rainald Mossner
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 9:437-42. 2006
    ..58 (95% CI 0.98-6.82). In conclusion, the results link TPH2 variations to the pathogenesis of early-onset OCD and further support the aetiological relevance of 5-HT signalling in OCD...
  13. ncbi Pathophysiology of obsessive-compulsive disorder: a necessary link between phenomenology, neuropsychology, imagery and physiology
    Bruno Aouizerate
    Service de Neurophysiologie Clinique, Centre Hospitalier Pellegrin, Universite Victor Segalen Bordeaux 2, CNRS UMR 5543, Place Amelie Raba Leon, 33076 Bordeaux, France
    Prog Neurobiol 72:195-221. 2004
    ..A dysfunction of these networks at one or several stages will result in the emergence and maintenance of repetitive thoughts and characteristic OCD behavior...
  14. ncbi Antibody-mediated neuronal cell signaling in behavior and movement disorders
    Christine A Kirvan
    Department of Biological Sciences, California State University Sacramento, Sacramento, CA 95618 6077, USA
    J Neuroimmunol 179:173-9. 2006
    ..Antibodies against GlcNAc in PANDAS sera were inhibited by lysoganglioside G(M1). Results suggest that antibodies from an infection may signal neuronal cells in some behavioral and movement disorders...
  15. pmc Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 189, Cambridge, CB2 2QQ UK
    Am J Psychiatry 164:335-8. 2007
    ..The aim was to assess inhibitory control processes in unaffected first-degree relatives of OCD patients for the first time with objective tests...
  16. ncbi The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers
    S R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, P O Box 189, Cambridge CB2 2QQ, UK
    Neurosci Biobehav Rev 29:399-419. 2005
    b>Obsessive compulsive disorder (OCD) is a highly debilitating neuropsychiatric condition with estimated lifetime prevalence of 2-3%, more than twice that of schizophrenia...
  17. ncbi Decision making performance in obsessive compulsive disorder
    M M A Nielen
    Department of Psychiatry, Academic Hospital Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    J Affect Disord 69:257-60. 2002
    ..As these areas are presumed to be involved in decision making, studying this behavior in OCD may provide further insight into the cognitive deficits accompanying the disorder...
  18. ncbi Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorder
    Kate Dimond Fitzgerald
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, 48109 0118, USA
    Biol Psychiatry 57:287-94. 2005
    ..In this functional magnetic resonance imaging (fMRI) study, we sought to further localize error-processing differences within the ACC of OCD patients compared with healthy subjects...
  19. ncbi Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases
    S E Swedo
    Section on Behavioral Pediatrics, NIMH, Rockville Pike, Bethesda, MD 20892 1381, USA
    Am J Psychiatry 155:264-71. 1998
    ....
  20. ncbi Dysfunctional action monitoring hyperactivates frontal-striatal circuits in obsessive-compulsive disorder: an event-related fMRI study
    Nicholas Maltby
    Anxiety Disorders Center, The Institute of Living Hartford Hospital, Hartford, CT 06106, USA
    Neuroimage 24:495-503. 2005
    ..These results suggest that correctly rejected, high-conflict trials that require response inhibition may provide a better model than error trials of compulsive behaviors in OCD...
  21. ncbi Gray matter structural alterations in psychotropic drug-naive pediatric obsessive-compulsive disorder: an optimized voxel-based morphometry study
    Philip R Szeszko
    Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 165:1299-307. 2008
    ....
  22. pmc Comorbidity and pathophysiology of obsessive-compulsive disorder in schizophrenia: is there evidence for a schizo-obsessive subtype of schizophrenia?
    Alexandra Bottas
    Department of Psychiatry, University of Toronto, ON, Canada
    J Psychiatry Neurosci 30:187-93. 2005
    ..We examine the evidence for a putative schizo-obsessive disorder and outline suggestions for identifying OCS in the presence of psychosis...
  23. ncbi The Obsessive-Compulsive Inventory: development and validation of a short version
    Edna B Foa
    Center for the Treatment and Study of Anxiety, University of Pennsylvania, 3535 Market Street, Suite 600N, Philadelphia, Pennsylvania 19104, USA
    Psychol Assess 14:485-96. 2002
    ..Receiver operating characteristic (ROC) analyses demonstrated the usefulness of the OCI-R as a diagnostic tool for screening patients with OCD, utilizing empirically derived cutscores...
  24. ncbi Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder
    Edna B Foa
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Psychiatry 162:151-61. 2005
    ..Serotonin reuptake inhibitors (SRIs) and cognitive behavior therapy by exposure and ritual prevention are both established treatments for OCD, yet their relative and combined efficacy have not been demonstrated conclusively...
  25. ncbi Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder
    Bon Mi Gu
    Interdisciplinary Program in Brain Science, Seoul National University College of Medicine, Korea
    Brain 131:155-64. 2008
    ..The results suggest that impaired task-switching ability in OCD patients might be associated with an imbalance in brain activation between dorsal and ventral frontal-striatal circuits...
  26. ncbi Cognitive retraining for organizational impairment in obsessive-compulsive disorder
    Ulrike Buhlmann
    Department of Psychiatry OCD Clinic, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
    Psychiatry Res 144:109-16. 2006
    ..These findings support a distinction in OCD between failure to utilize a strategy and incapacity to implement a strategy...
  27. ncbi Sexuality in women with obsessive compulsive disorder
    G Aksaray
    Department of Psychiatry, Osmangazi University School of Medicine, Eskisehir, Turkey
    J Sex Marital Ther 27:273-7. 2001
    This study assessed the effect of obsessive compulsive disorder (OCD) on sexual function...
  28. pmc Clarifying the convergence between obsessive compulsive personality disorder criteria and obsessive compulsive disorder
    Jane L Eisen
    Brown University Department of Psychiatry and Human Behavior, Butler Hospital, Providence 02906, USA
    J Pers Disord 20:294-305. 2006
    ..Future efforts to explore the link between Axis I and Axis II disorders may be enriched by conducting analyses at the symptom level...
  29. ncbi Neuropsychological performance in obsessive-compulsive disorder: a critical review
    Anne Katrin Kuelz
    Departments of Psychiatry and Psychotherapy, University Hospital of Freiburg, Albert Ludwig University, Hauptstrasse 5, Freiburg, Germany
    Biol Psychol 65:185-236. 2004
    ..The results of our study suggest that some cognitive deficits seem to be common in OCD, but future studies should focus more on possible confounding variables such as co-morbidity or psychotropic medication...
  30. ncbi Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder
    P R Szeszko
    Department of Psychiatry Research, Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 56:913-9. 1999
    ..These brain regions have not been well investigated in patients with OCD, however, using magnetic resonance imaging...
  31. ncbi Repetitive transcranial magnetic stimulation (rTMS) in the treatment of obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS)
    Antonio Mantovani
    Department of Neuroscience, Section of Psychiatry, Section of Neurophysiology, Postgraduate School in Applied Neurological Sciences, Siena University, Siena, Italy
    Int J Neuropsychopharmacol 9:95-100. 2006
    ..Slow rTMS to SMA resulted in a significant clinical improvement and a normalization of the right hemisphere hyperexcitability, thereby restoring hemispheric symmetry in motor threshold...
  32. ncbi Disorganization of anatomical connectivity in obsessive compulsive disorder: a multi-parameter diffusion tensor imaging study in a subpopulation of patients
    V Garibotto
    Vita Salute San Raffaele University, Milan, Italy
    Neurobiol Dis 37:468-76. 2010
    ..This altered anatomical connectivity might play a specific role in OCD pathophysiology...
  33. ncbi A critical evaluation of obsessive-compulsive disorder subtypes: symptoms versus mechanisms
    Dean McKay
    Department of Psychology, Fordham University, 441 East Fordham Road, Bronx, NY 10458 5198, USA
    Clin Psychol Rev 24:283-313. 2004
    ..The research is critically examined and implications for treatment are discussed. Recommendations for future investigations are offered...
  34. ncbi A pilot study of moderate-intensity aerobic exercise for obsessive compulsive disorder
    Richard A Brown
    Butler Hospital Brown Medical School, Providence, RI 02906, USA
    J Nerv Ment Dis 195:514-20. 2007
    ..examined the impact of aerobic exercise as an adjunctive intervention to regular care in reducing obsessive compulsive disorder (OCD) symptoms in a clinical sample. Fifteen patients (53% male; mean age = 44...
  35. ncbi Mapping structural brain alterations in obsessive-compulsive disorder
    Jesus Pujol
    Magnetic Resonance Center of Pedralbes, Barcelona, Spain
    Arch Gen Psychiatry 61:720-30. 2004
    ..Recent technical developments have made it feasible to comprehensively assess brain anatomy in psychiatric populations...
  36. pmc A case of mania following deep brain stimulation for obsessive compulsive disorder
    Ihtsham U Haq
    Department of Neurology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Stereotact Funct Neurosurg 88:322-8. 2010
    ..During a multiyear experience employing DBS to treat patients for obsessive compulsive disorder (OCD) we encountered several unanticipated stimulation-induced psychiatric side effects...
  37. ncbi Deep-brain stimulation of the nucleus accumbens in obsessive compulsive disorder: clinical, surgical and electrophysiological considerations in two consecutive patients
    Angelo Franzini
    Fondazione Istituto Nazionale Neurologico Carlo Besta, Via Caloria 11, 20133, Milan, Italy
    Neurol Sci 31:353-9. 2010
    b>Obsessive compulsive disorder is a highly disabling pathological condition which in the most severe and drug-resistant form can severely impair social, cognitive and interpersonal functioning...
  38. ncbi Self-injurious skin picking: clinical characteristics and comorbidity
    S Wilhelm
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Clin Psychiatry 60:454-9. 1999
    ..The authors examined the demographics, phenomenology, and associated psychopathology in a series of 31 subjects with this problem...
  39. ncbi Neuropsychological deficits in obsessive-compulsive disorder: a comparison with unipolar depression, panic disorder, and normal controls
    R Purcell
    Department of Psychology, The University of Melbourne, Royal Melbourne Hospital, Australia
    Arch Gen Psychiatry 55:415-23. 1998
    ..We directly compared cognitive function in patients with OCD with that in matched patients with unipolar depression and panic disorder and healthy control subjects to establish the specific nature of neuropsychological deficits in OCD...
  40. ncbi Basal Ganglia volumes in patients with Gilles de la Tourette syndrome
    Bradley S Peterson
    Division of Child and Adolescent Psychiatry, The Department of Psychiatry, New York State Psychiatric Institute and Columbia University College of Physicians and Surgeons, New York 10032, USA
    Arch Gen Psychiatry 60:415-24. 2003
    ....
  41. ncbi Prospective, longitudinal study of tic, obsessive-compulsive, and attention-deficit/hyperactivity disorders in an epidemiological sample
    B S Peterson
    Yale Child Study Center, Yale University School of Medicine, New Haven CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 40:685-95. 2001
    ..These findings are in general consistent with those from family studies, and they help to define the natural history, comorbid illnesses, and interrelatedness of these conditions...
  42. ncbi Is episodic obsessive compulsive disorder bipolar? A report of four cases
    C M Swartz
    Department of Psychiatry, Saint Louis University School of Medicine, MO 63104, USA
    J Affect Disord 56:61-6. 1999
    ..This perspective offers a new rationale for reported observations of remissions of acute onset OCD in response to lithium without lithium effectiveness for typical OCD...
  43. ncbi Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigation
    Perminder S Sachdev
    School of Psychiatry, University of New South Wales, Australia
    Psychol Med 37:1645-9. 2007
    To determine the efficacy and tolerability of repetitive transcranial magnetic stimulation (rTMS) as a treatment for obsessive compulsive disorder (OCD) in a double-blind placebo-controlled study.
  44. ncbi Obsessive-compulsive disorder as a disturbance of security motivation
    Henry Szechtman
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
    Psychol Rev 111:111-27. 2004
    ..The proposed model integrates many previous disparate observations and concepts about OCD and embeds it within the broader understanding of normal motivation...
  45. ncbi The effect of repetitive transcranial magnetic stimulation (rTMS) on symptoms in obsessive compulsive disorder. A randomized, double blind, sham controlled study
    Jan Prasko
    Psychiatric Centre Prague, Czech Republic
    Neuro Endocrinol Lett 27:327-32. 2006
    ..The goal of our study is to assess whether transcranial magnetic stimulation (rTMS) would facilitate the effect of antidepressant in OCD patients...
  46. pmc Plasma levels of tumor necrosis factor-alpha and interleukin-6 in obsessive compulsive disorder
    N Konuk
    Department of Psychiatry, Faculty of Medicine, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey
    Mediators Inflamm 2007:65704. 2007
    ..The aim of this study was to evaluate the plasma levels of the cytokines; tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in OCD patients...
  47. ncbi A double blind comparison of venlafaxine and paroxetine in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, University Medical Center B 01 206, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Psychopharmacol 23:568-75. 2003
    ..These results show that venlafaxine was equally effective to paroxetine in treating patients with OCD. Venlafaxine may be a useful therapy for obsessive-compulsive patients, but is not superior to SSRIs...
  48. ncbi Neuropsychology of obsessive-compulsive disorder: a review and treatment implications
    Scott Greisberg
    Department of Psychology, Fordham University, 441 East Fordham Road, Bronx, NY 10458 5198, USA
    Clin Psychol Rev 23:95-117. 2003
    ..Implications of this body of research for behavior therapy are considered...
  49. ncbi Screening young people for obsessive compulsive disorder
    Rudolf Uher
    South London and Maudsley NHS Trust, Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 191:353-4. 2007
    ..97 (95% CI 0.91-0.98) to detect OCD cases. Its specificity is good in children without psychiatric diagnoses, but low in a psychiatric sample. The SOCS is a screening tool suitable for community but not specialist settings...
  50. ncbi Olanzapine augmentation for treatment-resistant obsessive-compulsive disorder
    L M Koran
    Department of Psychiatry and Behavioral Sciences, Stanford Medical Center, Calif, USA
    J Clin Psychiatry 61:514-7. 2000
    ..Since olanzapine and risperidone have similar serotonergic and dopaminergic receptor binding profiles, we tested the hypothesis that olanzapine augmentation would be beneficial in treatment-unresponsive OCD...
  51. pmc Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome
    Michael H Bloch
    Yale Child Study Center, and General Clinical Research Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    Arch Pediatr Adolesc Med 160:65-9. 2006
    ..One half to two thirds of children with TS experience a reduction or complete resolution of tic symptoms during adolescence. At least one third of adults with TS have comorbid obsessive-compulsive disorder (OCD)...
  52. ncbi Bupropion in the treatment of pathological gambling: a randomized, double-blind, placebo-controlled, flexible-dose study
    Donald W Black
    Department of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    J Clin Psychopharmacol 27:143-50. 2007
    ..The high placebo response rate and the high noncompletion rate each reflect the challenge inherent in treating persons with PG...
  53. ncbi Brain activation in paediatric obsessive compulsive disorder during tasks of inhibitory control
    James Woolley
    Child and Adolescent Psychiatry PO 46, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK
    Br J Psychiatry 192:25-31. 2008
    ..Obsessive-compulsive disorder (OCD) may be related to a dysfunction in frontostriatal pathways mediating inhibitory control. However, no functional magnetic resonance imaging (fMRI) study has tested this in children...
  54. ncbi The epidemiology of obsessive-compulsive disorder in children and adolescents
    A H Zohar
    Scheinfeld Center for Human Genetics in the Social Sciences, Department of Psychology, Hebrew University, Jerusalem, Israel
    Child Adolesc Psychiatr Clin N Am 8:445-60. 1999
    ..The boundary of the diagnosis of OCD is not always easy to determine, and individuals may meet threshold and subthreshold criteria at different times...
  55. ncbi Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Victoria 3053, Australia
    Arch Gen Psychiatry 64:946-55. 2007
    ..However, the precise regions and the neural alterations associated with this abnormality remain unclear...
  56. ncbi Deep brain stimulation for intractable obsessive compulsive disorder: pilot study using a blinded, staggered-onset design
    Wayne K Goodman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Biol Psychiatry 67:535-42. 2010
    Prior promising results have been reported with deep brain stimulation (DBS) of the anterior limb of the internal capsule in cases with severe obsessive compulsive disorder (OCD) who had exhausted conventional therapies.
  57. ncbi Spatial working memory deficits in obsessive compulsive disorder are associated with excessive engagement of the medial frontal cortex
    Nic J A van der Wee
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 X Utrecht, The Netherlands
    Neuroimage 20:2271-80. 2003
    Recent studies have shown that obsessive compulsive disorder (OCD) is associated with a specific deficit in spatial working memory, especially when task difficulty (i.e., working memory load) is high...
  58. ncbi The relationship between obsessive-compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study
    G Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    Psychol Med 31:481-7. 2001
    ..CONCLUSION: GAD and agoraphobia share a common familial aetiology with OCD. The other anxiety and affective disorders, when comorbid with OCD, may emerge as a consequence of the OCD or as a more complex syndrome...
  59. ncbi Mycoplasma pneumoniae infection and obsessive-compulsive disease: a case report
    Tugba Erener Ercan
    Maltepe University Medical Faculty, Department of Pediatrics, Ataturk Cad Cam Sok No 3, Maltepe, Istanbul, Turkey
    J Child Neurol 23:338-40. 2008
    ..To our knowledge, this is the first report that shows the association between Mycoplasma pneumoniae infection and obsessive-compulsive disease...
  60. ncbi Symptom stability in adult obsessive-compulsive disorder: data from a naturalistic two-year follow-up study
    David Mataix-Cols
    Department of Psychiatry, Imperial College School of Medicine, London, UK
    Am J Psychiatry 159:263-8. 2002
    ..This study systematically investigated the temporal stability of individual symptoms and symptom dimensions of OCD in adult patients who were followed prospectively for 2 years...
  61. ncbi Overactive performance monitoring in obsessive-compulsive disorder: ERP evidence from correct and erroneous reactions
    Tanja Endrass
    Humboldt Universitat zu Berlin, Institut fur Psychologie, Rudower Chaussee 18, 12489 Berlin, Germany
    Neuropsychologia 46:1877-87. 2008
    ..This is in line with fMRI results that revealed higher error- and conflict-related activity in the medial frontal cortex in OCD patients...
  62. ncbi A naturalistic study of referred children and adolescents with obsessive-compulsive disorder
    Gabriele Masi
    IRCCS Stella Maris, Scientific Institute Child Neurology and Psychiatry, Calambrone, Pisa Italy
    J Am Acad Child Adolesc Psychiatry 44:673-81. 2005
    ..To report on clinical features, comorbidity, and response to pharmacotherapy in children and adolescents with obsessive-compulsive disorder (OCD) naturalistically followed and treated with serotonin reuptake inhibitors (SRIs)...
  63. ncbi Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 61:330-6. 2007
    ..Here, we used the SRT and functional magnetic resonance imaging (fMRI) to replicate prior results in a larger sample and to test for relationships between regional activation and OCD symptom dimensions...
  64. ncbi Repetitive behaviour in children with high functioning autism and obsessive compulsive disorder
    Fiona Zandt
    Department of Psychology, University of Melbourne, 3010, Melbourne, Australia
    J Autism Dev Disord 37:251-9. 2007
    Children with Autism Spectrum Disorders (ASD) and children with Obsessive Compulsive Disorder (OCD) were compared on a range of repetitive behaviours...
  65. ncbi Obsessive-compulsive bipolar comorbidity: focus on children and adolescents
    Gabriele Masi
    IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Pisa, Italy
    J Affect Disord 78:175-83. 2004
    Growing evidence documents the frequent co-morbidity between Obsessive Compulsive Disorder (OCD) and Bipolar Disorder (BP) in adults...
  66. ncbi D-cycloserine augmented exposure therapy for obsessive-compulsive disorder
    Matt G Kushner
    Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Biol Psychiatry 62:835-8. 2007
    ..We predicted that DCS would accelerate obsession-related distress reduction in patients with obsessive-compulsive disorder (OCD) undergoing extinction-based exposure therapy...
  67. pmc Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder
    Diana Hall
    The Rockefeller University, Human Neurogenetics Laboratory, New York, NY, 10021, USA
    Am J Hum Genet 73:370-6. 2003
    ....
  68. ncbi Switching from serotonin reuptake inhibitors to duloxetine in patients with resistant obsessive compulsive disorder: a case series
    Bernardo Dell'Osso
    Department of Psychiatry, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Psychopharmacol 22:210-3. 2008
    b>Obsessive compulsive disorder (OCD) is a chronic disorder, currently recognized as one of the most common psychiatric disorder as well as one of the most disabling of all medical disorders...
  69. ncbi Obsessive-compulsive symptom dimensions as predictors of compliance with and response to behaviour therapy: results from a controlled trial
    David Mataix-Cols
    Department of Psychiatry, Imperial College School of Medicine, London, UK
    Psychother Psychosom 71:255-62. 2002
    ..This study examined whether previously identified OCD symptom dimensions are associated with treatment compliance and response to behaviour therapy (BT) for OCD...
  70. ncbi White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 62:782-90. 2005
    ....
  71. ncbi Memory and attention in Obsessive-Compulsive Disorder: a review
    Jeffrey Muller
    Department of Psychology, The State University of New York at Buffalo, Park Hall, NY 14260 4110, USA
    J Anxiety Disord 19:1-28. 2005
    ..Finally, OCD appears to be associated with an attentional bias favoring threatening information, as well as reduced levels of cognitive inhibition. The manuscript concludes with a number of recommendations for future research...
  72. ncbi Assessing obsessive compulsive symptoms and cognitions on the internet: evidence for the comparability of paper and Internet administration
    Meredith E Coles
    Department of Psychology, Binghamton University SUNY, Binghamton, NY 13902 6000, USA
    Behav Res Ther 45:2232-40. 2007
    ..B., Kozak, M.J., Salkovskis, P.M, Coles, M.E., & Amir, N. (1998). The validation of a new obsessive compulsive disorder scale: The obsessive-compulsive inventory...
  73. ncbi Decreased TNF-alpha and NK activity in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychoneuroendocrinology 29:945-52. 2004
    ..This study was carried out to investigate whether obsessive-compulsive disorder is associated with altered activity of the immune system, and whether these changes are related to particular clinical characteristics...
  74. ncbi The Vancouver Obsessional Compulsive Inventory (VOCI)
    Dana S Thordarson
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, V6T 1Z4, Canada
    Behav Res Ther 42:1289-314. 2004
    ..We anticipate that, like its predecessor, the VOCI will have widespread use in both research and clinical settings...
  75. ncbi Anxiety disorders associated with traumatic brain injuries
    D Walter Hiott
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Ralph H Johnson VAMC, Charleston 29412, USA
    NeuroRehabilitation 17:345-55. 2002
    ..of traumatic brain injury, specifically post-traumatic stress disorder, generalized anxiety disorder, obsessive compulsive disorder, and panic disorder...
  76. ncbi Regional gray matter abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study
    Antonio A Valente
    Department of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Biol Psychiatry 58:479-87. 2005
    ..This might be partly related to their use of a regions-of-interest approach. We assessed gray matter volumes in 19 OCD subjects and 15 healthy volunteers, using voxel-based morphometry (VBM)...
  77. pmc Quality of life and functional impairment in obsessive-compulsive disorder: a comparison of patients with and without comorbidity, patients in remission, and healthy controls
    Jonathan D Huppert
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Depress Anxiety 26:39-45. 2009
    ....
  78. ncbi Relationship between psychotic and obsessive compulsive symptoms in schizophrenia
    Francois Guillem
    Departement de Psychiatrie, Université de Montréal 7331 Hochelaga, Centre de Recherche F Seguin, Hopital L H Lafontaine, Montreal, QC, Canada
    Schizophr Res 115:358-62. 2009
    ..These results may reflect that these OCSs have a protective effect against disorganization and psychotic symptoms respectively...
  79. ncbi Executive functions in obsessive-compulsive disorder: state or trait deficits?
    Shelley Bannon
    Brain and Behaviour Research Institute, School of Psychology, University of Wollongong, New South Wales, and Department of Psychological Medicine, Westmead Hospital, Sydney, Australia
    Aust N Z J Psychiatry 40:1031-8. 2006
    ..The current research examines the executive functions in OCD in a comprehensive manner and, for the first time, assesses the stability of these deficits over the developmental course of the disorder...
  80. ncbi Impaired response inhibition in obsessive compulsive disorder
    R Penadés
    Clinical Institute of Neurosciences, Hospital Clinic, C Villarroel 170, 08036 Barcelona, Spain
    Eur Psychiatry 22:404-10. 2007
    ..Selective motor response inhibition was tested in a GO/NO-GO paradigm, the inhibition of a triggered motor response in a STOP paradigm and the ability to inhibit cognitive interference in a motor STROOP paradigm...
  81. ncbi Action-monitoring dysfunction in obsessive-compulsive disorder
    W J Gehring
    Department of Psychology, University of Michigan, 525 East University Ave, Ann Arbor, MI 48109 1109, USA
    Psychol Sci 11:1-6. 2000
    ..The magnitude of this enhancement correlated with symptom severity. Dipole modeling suggested that the locus of the enhancement corresponded to medial frontal regions, possibly the anterior cingulate cortex...
  82. ncbi Obsessive-compulsive symptoms and disorder in patients with schizophrenia treated with clozapine or haloperidol
    Antonio R Sa
    Department and Institute of Psychiatry, Clinical Hospital, Faculty of Medicine, University of Sao Paulo, Brazil
    Compr Psychiatry 50:437-42. 2009
    ..These results may support an association between the exacerbation of obsessive-compulsive phenomena and the use of clozapine...
  83. ncbi Caudate regional cerebral blood flow in obsessive-compulsive disorder, panic disorder and healthy controls on single photon emission computerised tomography
    J V Lucey
    Department of Psychological Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, West Smithfield, UK
    Psychiatry Res 74:25-33. 1997
    ..The data suggest functional involvement of the right caudate nucleus is present in OCD...
  84. ncbi D-cycloserine does not enhance exposure-response prevention therapy in obsessive-compulsive disorder
    Eric A Storch
    Departments of Psychiatry, University of Florida, Florida 32610, USA
    Int Clin Psychopharmacol 22:230-7. 2007
    ..As this study is the first to explore this question and a number of methodological issues must be considered when interpreting the findings, the conclusions that may be drawn from our results are limited...
  85. ncbi Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder
    Joaquim Radua
    Division of Psychological Medicine, Institute of Psychiatry, PO 69, King s College London, London SE5 8AF
    Br J Psychiatry 195:393-402. 2009
    ..Specific cortico-striato-thalamic circuits are hypothesised to mediate the symptoms of obsessive-compulsive disorder (OCD), but structural neuroimaging studies have been inconsistent...
  86. ncbi Frontostriatal measurement in treatment-naive children with obsessive-compulsive disorder
    D R Rosenberg
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 54:824-30. 1997
    ....
  87. ncbi Understanding and treating incompleteness in obsessive-compulsive disorder
    Laura J Summerfeldt
    Trent University, Department of Psychology, Peterborough, Ontario, Canada
    J Clin Psychol 60:1155-68. 2004
    ..However, even these may result in modest long-term gains; relapse is a probability if they are not actively practiced after treatment cessation...
  88. ncbi A genetic family-based association study of OLIG2 in obsessive-compulsive disorder
    S Evelyn Stewart
    Psychiatric Neuroscience Research Division, and Obsessive Compulsive Disorder Clinic, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Gen Psychiatry 64:209-14. 2007
    ..The gene for oligodendrocyte lineage transcription factor 2 (OLIG2) is an essential regulator in the development of cells that produce white matter (myelin). The OLIG2 gene is also highly expressed in brain regions implicated in OCD...
  89. pmc Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative review
    Naomi A Fineberg
    Department of Psychiatry, National OCDs Specialist Centre, Hertfordshire Partnership NHS Foundation Trust, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UK
    Neuropsychopharmacology 35:591-604. 2010
    ..Targeted application of neurocognitive tasks, receptor-specific neurochemical probes, and brain systems neuroimaging techniques have potential for future research in this field...
  90. ncbi Do antipsychotics ameliorate or exacerbate Obsessive Compulsive Disorder symptoms? A systematic review
    Jitender Sareen
    Department of Psychiatry, Obsessive Compulsive Disorder Clinic, University of Manitoba, PZ 203 771 Bannatyne Avenue, Winnipeg, MB, R3E 3N4, Canada
    J Affect Disord 82:167-74. 2004
    Paradoxically, some reports in the literature support the use of antipsychotics in the treatment of Obsessive Compulsive Disorder (OCD), while other reports suggest that antipsychotics can exacerbate OCD symptoms...
  91. ncbi Memantine augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial
    Elias Aboujaoude
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Psychopharmacol 29:51-5. 2009
    ..We report on the first open-label study to test the hypothesis that memantine, a noncompetitive glutamate antagonist, will result in a clinically meaningful reduction in OCD symptoms in adults with treatment-resistant OCD...
  92. ncbi The Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS): an instrument for assessing obsessive-compulsive symptom dimensions
    M C Rosario-Campos
    Department of Psychiatry, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Mol Psychiatry 11:495-504. 2006
    ....
  93. ncbi Multicenter investigation of the opioid antagonist nalmefene in the treatment of pathological gambling
    Jon E Grant
    Department of Psychiatry, University of Minnesota Medical School, 2450 Riverside Avenue, Minneapolis, MN 55454, USA
    Am J Psychiatry 163:303-12. 2006
    ..The authors examined the efficacy and tolerability of the opioid antagonist nalmefene in the treatment of adults with pathological gambling...
  94. ncbi Behavioral versus pharmacological treatments of obsessive compulsive disorder: a meta-analysis
    K A Kobak
    Dean Foundation for Health, Research and Education, Middleton, WI 53562, USA
    Psychopharmacology (Berl) 136:205-16. 1998
    ..serotonin reuptake inhibitors (SRIs) and behavior therapy [exposure and response prevention (ERP)] for obsessive compulsive disorder. The relationship between effect size and methodological characteristics was also empirically examined...
  95. ncbi Olanzapine augmentation of fluvoxamine-refractory obsessive-compulsive disorder (OCD): a 12-week open trial
    F Bogetto
    Service for Depressive and Anxiety Disorders, Department of Neuroscience, University of Turin, Via Cherasco 11, 10126, Turin, Italy
    Psychiatry Res 96:91-8. 2000
    ..It appears that augmentation of olanzapine in fluvoxamine-refractory OCD may be effective in a large number of patients, including those with comorbid schizotypal personality disorder...
  96. ncbi Obsessive-compulsive traits in children and adolescents with Asperger syndrome
    Liliana Ruta
    Division of Child Neurology and Psychiatry, Department of Paediatrics, University of Catania, 95123 Catania, Italy
    Eur Child Adolesc Psychiatry 19:17-24. 2010
    ..behaviours in children and adolescents with Asperger syndrome (AS), with respect to a matched obsessive compulsive disorder group (OCD) and a typically developing control group (CG)...
  97. ncbi Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls
    Yousha Mirza
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Child Neurol 21:106-11. 2006
    ..Although these results must be considered preliminary, further study of the diagnostic specificity of creatine-phosphocreatine in obsessive-compulsive disorder is indicated...
  98. ncbi Treatment of obsessive-compulsive disorder by U.S. psychiatrists
    Carlos Blanco
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 67:946-51. 2006
    ..To examine the treatment of obsessive-compulsive disorder (OCD) by a nationally representative sample of psychiatrists...
  99. ncbi The OCI-R: validation of the subscales in a clinical sample
    Jonathan D Huppert
    University of Pennsylvania School of Medicine, Center for Treatment and Study of Anxiety, 3535 Market St, Suite 600N, Philadelphia, PA 19104, United States
    J Anxiety Disord 21:394-406. 2007
    ..Further research should examine the sensitivity of the specific subscales to treatment effects, and the potential for adding more items to account for other symptom domains of OCD...
  100. ncbi Clinical features associated to refractory obsessive-compulsive disorder
    Ygor A Ferrão
    Department of Psychiatry, University of Sao Paulo Medical School, Sao Paulo, Brazil
    J Affect Disord 94:199-209. 2006
    ..The clinical variables associated with treatment-refractoriness in OCD are inconsistently described in the literature...

Research Grants81

  1. Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic Manipulations
    Petr Tvrdik; Fiscal Year: 2013
    ..disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis, as well as obsessive compulsive disorder and schizophrenia...
  2. Serotonin transporter-mediated regulation of neuroendocrine exocytosis
    KEVIN P CURRIE; Fiscal Year: 2013
    ..in SERT are associated with several neuropsychiatric disorders including depression, anxiety, obsessive compulsive disorder, and autism...
  3. Functionally Significant Polymorphisms in Serotonin Pathway Genes
    Beverly H Koller; Fiscal Year: 2010
    ..has been implicated in many psychiatric and affective disorders including depression, autism, and obsessive compulsive disorder. These associations are supported by the demonstration that 5-HTT is the major site of action of many ..
  4. NEURONAL CONTROL OF INTERACTIONS AMONG BEHAVIORS
    William B Kristan; Fiscal Year: 2013
    ..The comparative approach has a long and fruitful history: questions answered in simple animals provide information and inspiration for asking the same questions in more complex animals, like rats, monkeys, and eventually humans. ..
  5. From Defective Microglia to Cortical Activity and Pathological Behavior
    Mario R Capecchi; Fiscal Year: 2013
    ..Immunological dysfunction have been widely linked to many neuropsychiatric disorders including obsessive compulsive disorder (OCD), major depression, bipolar disorder, autism, schizophrenia and Alzheimer disease...
  6. Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
    KENNETH J CAMPBELL; Fiscal Year: 2013
    ..this circuit has also been implicated in the neurodevelopmental disorders Tourette's syndrome and obsessive compulsive disorder (OCD)...
  7. Kainate receptor signaling in striatal synaptic function and plasticity
    John Marshall; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Obsessive Compulsive Disorder (OCD) is a chronic anxiety disorder characterized by maladaptive compulsive behavior such as excessive grooming, hoarding or checking...
  8. CRCNS: Propagation of beta oscillations in cortico-basal ganglia-thalamic loop
    Michelle M McCarthy; Fiscal Year: 2013
    ....
  9. Conformational Changes Underlying Intracellular Gating of the Leucine Transporter
    Kelli Kazmier; Fiscal Year: 2012
    ..system such as depression, anxiety, autism, epilepsy, attention deficit hyperactivity disorder, and obsessive compulsive disorder as well as abuse and addiction to illicit drugs such as cocaine and amphetamine...
  10. Roles of Gsh1 &Gsh2 in Telencephalic Neurogenesis
    KENNETH J CAMPBELL; Fiscal Year: 2012
    ..disorders such as Tourette's syndrome, attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD) are thought to result at least in part from abnormal function/development of the striatum...
  11. Locus Coeruleus-Norepinephrine System Regulation of Prepulse Inhibition
    Vaishali P Bakshi; Fiscal Year: 2010
    ..dysfunction in these filtering systems represents a core endophenotype manifested in schizophrenia, obsessive compulsive disorder, tic disorders, and possibly attention deficit hyperactivity disorder and post traumatic stress ..
  12. Gender Effects on Amphetamine-Induced Dopamine Release and Subjective Responses
    Mary E McCaul; Fiscal Year: 2013
    ....
  13. Neural Encoding of Internal Motivational States and Goal-Directed Actions
    ALAINA CATHERINE CASE; Fiscal Year: 2011
    ....
  14. A Novel Strategy for Combating Obesity: Reprogramming Neural Circuits
    KAY MAXINE TYE; Fiscal Year: 2013
    ..to other neuropsychiatric disorders including addiction, anxiety, depression, bipolar disorder and obsessive compulsive disorder (OCD)...
  15. ORGANIZATION OF PREFRONTAL FEEDBACK CIRCUITS
    Helen Barbas; Fiscal Year: 2013
    ..in processes that are disrupted in psychiatric diseases, including post traumatic stress disorder, obsessive compulsive disorder and depression...
  16. 5-HT1B receptor function in OCD
    CHRISTOPHER JOHN PITTENGER; Fiscal Year: 2012
    ..Better understanding of abnormalities in the serotonin system in OCD will pave the way for new pharmacological treatments of this severe neuropsychiatric disorder. ..
  17. Serotonergic modulation of claustro-cortical circuits
    Jay A Gingrich; Fiscal Year: 2013
    ..The tools and results from this study can be used in the future to directly manipulate neuronal activity of the CL and reveal new neural substrates of serotonergic action on emotional and cognitive function. ..
  18. Transgenic Mouse Model to Address Heterogeneity in Autism Spectrum Disorders
    RANDY DEAN BLAKELY; Fiscal Year: 2010
    ..Based on exciting preliminary evidence that mice expressing Ala56 SERT exhibit multiple behavioral and biochemical phenotypes, we propose a two-year project to extend our studies and dissect the impact of SERT hyperfunction in vivo. ..
  19. Basal Ganglia and Higher Cortical Function
    Peter L Strick; Fiscal Year: 2012
    ..This information may lead to new avenues for treatment of complex disorders like Depression, OCD and TS. ..
  20. Application of MR Spectroscopy Techniques to Animal Models of Obstetric Complicat
    APRIL ELIZABETH RONCA; Fiscal Year: 2010
    ..autism, Attention Deficit Hyperactivity Disorder (ADHD), Tourette's Syndrome (TS) and Obsessive Compulsive Disorder (OCD)...
  21. RESEARCH TRAINING - BIOLOGICAL SCIENCES
    Ronald S Duman; Fiscal Year: 2013
    ..The basic research conducted by the faculty and trainees during their time at Yale and later in their careers will lead to identification and development of novel and more effective therapeutic strategies. ) ..
  22. 1/2-D-Cycloserine Augmentation of CBT for Pediatric OCD
    Eric A Storch; Fiscal Year: 2013
    ..This study will yield clinically important data, which could ultimately improve the treatment of youth with OCD and reduce exposure to potentially harmful medications. ..
  23. 2/2-D-Cycloserine Augmentation of CBT for Pediatric OCD
    Daniel A Geller; Fiscal Year: 2013
    ..This study will yield clinically important data, which could ultimately improve the treatment of youth with OCD and reduce exposure to potentially harmful medications. ..
  24. Deep Brain Stimulation in the Parkinsonian Monkey
    Jerrold L Vitek; Fiscal Year: 2012
    ..exploration of surgical therapy for a wide range of neurological disorders including tremor, dystonia, obsessive compulsive disorder, depression, Tourette syndrome, addiction, pain and epilepsy...
  25. Organization of the Cortical Projection to the Basal Ganglia
    ANTON J REINER; Fiscal Year: 2012
    ....
  26. Interdisciplinary Predoctoral Neuroscience Training Program
    Diane Lipscombe; Fiscal Year: 2013
    ..to meet and talk with patients suffering from diseases of the nervous system including those with Obsessive Compulsive Disorder, Aphasia, Parkinson's Disease, and Addiction...
  27. The role of glutamate receptors in compulsive and perseverative behavior
    Anis Contractor; Fiscal Year: 2013
    ....
  28. Performance Error Signals in Basal Ganglia-Forebrain Circuits of the Songbird
    Michale S Fee; Fiscal Year: 2013
    ..Disorders of BG circuitry lead to the impairments of serial processing and sequential behaviors observed in Parkinson's disease, schizophrenia, obsessive-compulsive disorder, Huntington's and the tardive syndromes. ..
  29. Early Life Stress and Depression: Molecular and Functional Imaging Approaches
    Diego A Pizzagalli; Fiscal Year: 2013
    ..and/or striatal pathways (attention deficit hyperactivity disorder, substance dependence/abuse, obsessive compulsive disorder) or disorders that might represent a pathway to depression (post traumatic stress disorder) will be ..
  30. CONTINUITY OF LIMBIC CIRCUIT THROUGH THE BASAL GANGLIA
    Suzanne N Haber; Fiscal Year: 2013
    ..This developmental period is also the time when there is a great deal of anatomical refinement of circuits. ..
  31. 6/8-Collaborative genomic studies of Tourette Disorder
    Dorothy E Grice; Fiscal Year: 2013
    ..With no cost to this project, PAXgene tubes will be collected from all subjects and made available to the scientific community to enable future studies by our group and others. ..
  32. 8/8-Collaborative Genomic Studies of Tourette Disorder
    Bennett L Leventhal; Fiscal Year: 2013
    ..With no cost to this project, PAXgene tubes will be collected from all subjects and made available to the scientific community to enable future studies by our group and others. ..
  33. 3/8-Collaborative Genomic Studies of Tourette Disorder
    Lawrence W Brown; Fiscal Year: 2013
    ..With no cost to this project, PAXgene tubes will be collected from all subjects and made available to the scientific community to enable future studies by our group and others. ..
  34. 2/8-Collaborative genomic studies of Tourette Disorder
    Matthew W State; Fiscal Year: 2013
    ..With no cost to this project, PAXgene tubes will be collected from all subjects and made available to the scientific community to enable future studies by our group and others. ..
  35. 5/8-Collaborative Genomic Studies of Tourette Disorder
    Samuel Kuperman; Fiscal Year: 2013
    ..With no cost to this project, PAXgene tubes will be collected from all subjects and made available to the scientific community to enable future studies by our group and others. ..
  36. 3/3-Brain Chemistry and Genetics in Pediatric OCD
    Paul Daniel Arnold; Fiscal Year: 2013
    ..b>Obsessive compulsive disorder (OCD) is a severe, prevalent, and chronically disabling disorder that emerges during childhood in as ..
  37. Genomics of Developmental Trajectories in Twins
    James J Hudziak; Fiscal Year: 2010
    ..to risk for complex traits such as common developmental psychopathology like childhood ADHD, Obsessive Compulsive Disorder (OCD), Oppositional Defiant Disorder (ODD) have not yet been reported in the literature...
  38. Linking genes to higher brain function by way of cellular electrophysiology
    Gaby Maimon; Fiscal Year: 2012
    ..By providing a deeper understanding of decision-making circuits, the proposed work can ultimately yield insight into treatments for a variety of mental illnesses, such as depression, one of the leading causes of disability in the world. ..
  39. Visual Target Selection for Saccadic Eye Movements
    Michele A Basso; Fiscal Year: 2013
    ..abstract_text> ..
  40. Ontogeny of caudate-putamen functioning: behavioral relevance
    SANDERS MCDOUGALL; Fiscal Year: 2013
    ..This type of ontogenetic research is necessary to determine the neural bases of developmental neuropsychiatric disorders. ..
  41. Postsynaptic Protein Trafficking and Synapse Remodeling
    Sang H Lee; Fiscal Year: 2013
    ..Thus, studying the function of GKAP in synaptic plasticity not only help understanding the higher cognitive function of human but also is directly relevant to disease. ..
  42. AMY-1 receptors: Novel targets for antipsychotic development
    Brian A Baldo; Fiscal Year: 2012
    ..In the course of this last study, we will also determine whether amylin-related genes themselves are developmentally regulated. ..
  43. Genetic analysis of simple learning behaviors
    Michael Granato; Fiscal Year: 2013
    ....
  44. Novel Interventions for Adults with Obsessive-Compulsive Disorder
    Carolyn I Rodriguez; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Obsessive compulsive disorder (OCD) is a leading cause of illness related disability. More effective treatments with fewer side effects and faster onset of action are desperately needed...
  45. Voltammetry of 5-HT Transmission in Psychiatric &Degenerative Disease Models
    Anne Milasincic Andrews; Fiscal Year: 2011
    ..in combination with an lle425Val coding region substitution mutation found in rare familiar forms of obsessive compulsive disorder;and (2) Employ fast cyclic voltammetry to characterize alterations in the dynamics of serotonin ..
  46. Photoprobes for identifying potential anti-depressant and anti-anxiety medication
    DAVID JOHN LAPINSKY; Fiscal Year: 2013
    ..g., depression, anxiety, autism, obsessive- compulsive disorder) and refine SERT molecular models for computer-aided drug discovery efforts (i.e., virtual / in silico screening, structure-based drug design). ..
  47. CELLULAR MECHANISMS OF ASSOCIATIVE LEARNING
    John H Byrne; Fiscal Year: 2012
    ..A more in depth understanding of the mechanisms of reward-related learning may provide insights into related disorders, such as addiction, obsessive compulsive disorder, impulsivity, AD/HD, schizophrenia and eating disorders.
  48. Development of a Behavioral Team Intervention for Obsessive Compulsive Disorder
    Maria C Mancebo; Fiscal Year: 2013
    ....
  49. Roles of Kainate Receptors in Compulsive-Like Behaviors
    Jian Xu; Fiscal Year: 2013
    ..The use of novel animal models will provide important insight into the roles of kainate receptors in pathogenesis of OCD. ..
  50. Action Monitoring and Genomic Variants in Pediatric Obsessive-Compulsive Behavior
    Gregory L Hanna; Fiscal Year: 2013
    ..Our work will provide a better understanding of ACC dysregulation in the pathogenesis of childhood OC behaviors and lead to new prevention and treatment strategies. ..
  51. The Neural Basis of Instrumental Action
    Bernard W Balleine; Fiscal Year: 2012
    ....
  52. Glutamate in OCD: a magnetic resonance spectroscopy study.
    CHRISTOPHER JOHN PITTENGER; Fiscal Year: 2013
    ....
  53. Phenomenology of Obsessive Compulsive Personality Disorder
    Anthony Pinto; Fiscal Year: 2012
    ..functioning (from both the patient and family perspective), and the controversial relationship with obsessive compulsive disorder (OCD)...
  54. 2/2-Attaining and Maintaining Wellness in OCD
    Edna B Foa; Fiscal Year: 2013
    ....
  55. THE ROLE OF PREFRONTAL REGIONS IN ECONOMIC CHOICE AND CHOICE-GUIDED BEHAVIOR
    Camillo Padoa-Schioppa; Fiscal Year: 2013
    ..By addressing some of the most pressing and open questions, this research may shape our understanding of the neural mechanisms that underlie EC and that malfunction in mental illness. ..
  56. Deep Brain Stimulation Array for Neuromodulation
    Rio J Vetter; Fiscal Year: 2013
    ..In so doing, this project will increase the impact of leading-edge neurotechnology on improving and advancing treatments of significant neurological disorders in the US and global markets. ..
  57. Cortical connections with the limbic territory of the basal ganglia
    Michelle Morrow; Fiscal Year: 2007
    ..This information may result in new avenues for treatment of complex disorders like OCD and TS. [unreadable] [unreadable] [unreadable]..
  58. Cortical contributions to basal ganglia disorders
    PETER STRICK; Fiscal Year: 2006
    ..abstract_text> ..
  59. FACTORS AFFECTING OCD AND HEALTH DISPARITIES AT THE U.S.-MEXICO BORDER
    Thomas Olson; Fiscal Year: 2007
    ..As such, this research can provide an important contribution to issues of health disparity. [unreadable] [unreadable] [unreadable]..
  60. Neural Mechanisms of Reinforcement Learning in the Basal Ganglia
    Kareem Zaghloul; Fiscal Year: 2009
    ..during deep brain stimulation surgery (DBS) for the treatment of Parkinson's disease (PD) and obsessive compulsive disorder (OCD) to formally investigate learning mechanisms within the human basal ganglia...
  61. Time Course and Potentiation of Fluoxetin Action
    George Battaglia; Fiscal Year: 2004
    ..These disorders include anxiety, obsessive compulsive disorder, aggression, eating disorders and premenstrual syndrome...
  62. Cellular mechanisms mediating extinction of conditioned fear
    Vadim Bolshakov; Fiscal Year: 2009
    ..A better knowledge of the cellular mechanisms of fear-related behavior will permit the rational development of novel therapeutic treatments for posttraumatic stress disorder (PTSD) and generalized anxiety. ..
  63. MOLECULAR APPROACHES TO CHILDHOOD PSYCHIATRIC DISORDERS
    Matthew State; Fiscal Year: 2006
    ..He currently divides his time between attending in the Tourette syndrome (TS) and Obsessive Compulsive Disorder (OCD) clinics and conducting research in the laboratory...
  64. Deep Brain Stimulation Array for Neuromodulation
    RIO VETTER; Fiscal Year: 2007
    ..DBS is a common therapeutic approach for the treatment of Parkinson's Disease, and potentially other movement related disorders. [unreadable] [unreadable] [unreadable]..
  65. R21 Project: St. John's Wort vs. Placebo in OCD
    Kenneth Kobak; Fiscal Year: 2003
    b>Obsessive compulsive disorder (OCD), a syndrome characterized by obsessions and compulsions, has a lifetime prevalence of 1-2%...
  66. NEUROBIOLOGY AND TREATMENT OF OCD
    Wayne Goodman; Fiscal Year: 1999
    b>Obsessive Compulsive Disorder (OCD) is a common, often chronic, and sometimes disabling neuropsychiatric condition...
  67. NEUROANATOMY AND PHARMACOTHERAPY OF OCD AND MAJOR DEPRES
    Sanjaya Saxena; Fiscal Year: 2003
    ..abstract_text> ..
  68. Functionally Significant Polymorphisms in Serotonin Pathway Genes
    Beverly Koller; Fiscal Year: 2009
    ..has been implicated in many psychiatric and affective disorders including depression, autism, and obsessive compulsive disorder. These associations are supported by the demonstration that 5-HTT is the major site of action of many ..
  69. CODING OF BEHAVIORAL SEQUENCES IN THE BASAL GANGLIA
    J Aldridge; Fiscal Year: 2001
    ..repetition of spoken words in Tourette's syndrome and the tormenting habits and thoughts of obsessive compulsive disorder suggest that sequential control mechanisms may be a fundamental property of the basal ganglia...
  70. Prospective Study of 'PANDAS'
    Tanya Murphy; Fiscal Year: 2006
    ..Confirmation of a relationship of this putative subtype of obsessive compulsive disorder (OCD) and Tourette's Syndrome (TS) to an antecedent Group A Streptococcal (GAS) has gained ..
  71. BRAIN MORPHOLGY IN OBSESSIVE-COMPULSIVE DISORDER
    Delbert Robinson; Fiscal Year: 1993
    ....
  72. Emotional induced attentional blink in OCD
    Olubunmi Olatunji; Fiscal Year: 2009
    ....
  73. Pilot Study of DBS for Treatment-Refractory OCD
    Herbert Ward; Fiscal Year: 2006
    ..If shown effective, DBS might replace ablative neurosurgery, but should still be considered the intervention of last resort in the most profoundly ill and intractable cases of OCD. ..
  74. TREATMENT OF PEDIATRIC OBSESSIVE COMPULSIVE DISORDER
    John March; Fiscal Year: 2001
    ....
  75. TREATMENT OF PEDIATRIC OBSESSIVE COMPULSIVE DISORDER
    Edna Foa; Fiscal Year: 2001
    ....