neuropsychological tests

Summary

Summary: Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.

Top Publications

  1. ncbi Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
    Henry Engler
    Uppsala Imanet AB, Imanet, GE Healthcare Uppsala University, Uppsala
    Brain 129:2856-66. 2006
  2. ncbi The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis
    A Miyake
    Department of Psychology, University of Colorado at Boulder, 80309-0345, USA
    Cogn Psychol 41:49-100. 2000
  3. ncbi Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 26:231-9. 2005
  4. ncbi Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
  5. ncbi Mild cognitive impairment as a diagnostic entity
    R C Petersen
    Department of Neurology, Alzheimer s Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Intern Med 256:183-94. 2004
  6. ncbi The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment
    Ziad S Nasreddine
    Center for Clinical Research, Neurology Service, Hopital Charles LeMoyne, Quebec, Canada
    J Am Geriatr Soc 53:695-9. 2005
  7. pmc Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
    Katya Rascovsky
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 3 West Gates, Philadelphia, PA 19104, USA
    Brain 134:2456-77. 2011
  8. pmc HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
    R K Heaton
    University of California, San Diego, USA
    Neurology 75:2087-96. 2010
  9. ncbi Fitness effects on the cognitive function of older adults: a meta-analytic study
    Stanley Colcombe
    Beckman Institute and Department of Psychology, University of Illinois, Urbana, 61801, USA
    Psychol Sci 14:125-30. 2003
  10. ncbi The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening
    Eneida Mioshi
    MRC Cognition and Brain Sciences Unit, University of Cambridge, Department of Clinical Neurosciences, Addenbrooke s Hospital, UK
    Int J Geriatr Psychiatry 21:1078-85. 2006

Detail Information

Publications352 found, 100 shown here

  1. ncbi Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
    Henry Engler
    Uppsala Imanet AB, Imanet, GE Healthcare Uppsala University, Uppsala
    Brain 129:2856-66. 2006
    ..FDG imaging may be able to detect a stabilization of cerebral metabolism caused by therapy administered to patients with a clinical diagnosis of Alzheimer's disease...
  2. ncbi The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis
    A Miyake
    Department of Psychology, University of Colorado at Boulder, 80309-0345, USA
    Cogn Psychol 41:49-100. 2000
    ..These results suggest that it is important to recognize both the unity and diversity of executive functions and that latent variable analysis is a useful approach to studying the organization and roles of executive functions...
  3. ncbi Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 26:231-9. 2005
    ..These findings suggest that altered activity in the default mode network may act as an early marker for AD pathology...
  4. ncbi Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
    ....
  5. ncbi Mild cognitive impairment as a diagnostic entity
    R C Petersen
    Department of Neurology, Alzheimer s Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Intern Med 256:183-94. 2004
    ..By refining the criteria for MCI, clinical trials can be designed with appropriate inclusion and exclusion restrictions to allow for the investigation of therapeutics tailored for specific targets and populations...
  6. ncbi The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment
    Ziad S Nasreddine
    Center for Clinical Research, Neurology Service, Hopital Charles LeMoyne, Quebec, Canada
    J Am Geriatr Soc 53:695-9. 2005
    ..To develop a 10-minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first-line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia...
  7. pmc Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
    Katya Rascovsky
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 3 West Gates, Philadelphia, PA 19104, USA
    Brain 134:2456-77. 2011
    ..Future studies will be needed to establish the reliability and specificity of these revised diagnostic guidelines...
  8. pmc HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
    R K Heaton
    University of California, San Diego, USA
    Neurology 75:2087-96. 2010
    ....
  9. ncbi Fitness effects on the cognitive function of older adults: a meta-analytic study
    Stanley Colcombe
    Beckman Institute and Department of Psychology, University of Illinois, Urbana, 61801, USA
    Psychol Sci 14:125-30. 2003
    ..The results are discussed in terms of recent neuroscientific and psychological data that indicate cognitive and neural plasticity is maintained throughout the life span...
  10. ncbi The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening
    Eneida Mioshi
    MRC Cognition and Brain Sciences Unit, University of Cambridge, Department of Clinical Neurosciences, Addenbrooke s Hospital, UK
    Int J Geriatr Psychiatry 21:1078-85. 2006
    ..There is a clear need for brief, but sensitive and specific, cognitive screening instruments as evidenced by the popularity of the Addenbrooke's Cognitive Examination (ACE)...
  11. pmc Classification of primary progressive aphasia and its variants
    M L Gorno-Tempini
    Memory and Aging Center, Department of Neurology, UCSF, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143 1207, USA
    Neurology 76:1006-14. 2011
    ..Future collaborations will collect prospective data to identify relationships between each of these syndromes and specific biomarkers for a more detailed understanding of clinicopathologic correlations...
  12. ncbi Updated research nosology for HIV-associated neurocognitive disorders
    A Antinori
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Instituto di Ricovero e Cura a Carattere Scientifico IRCCS, Rome, Italy
    Neurology 69:1789-99. 2007
    ..An algorithm is proposed to assist in standardized diagnostic classification of HAND...
  13. ncbi Anterior cingulate conflict monitoring and adjustments in control
    John G Kerns
    Department of Psychological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Science 303:1023-6. 2004
    ....
  14. pmc Cognitive reserve
    Yaakov Stern
    Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, United States
    Neuropsychologia 47:2015-28. 2009
    ..It then focuses on methodologic issues that are important when attempting to elucidate the neural underpinnings of cognitive reserve using imaging studies, and reviews some of our group's work in order to demonstrate these issues...
  15. ncbi What is cognitive reserve? Theory and research application of the reserve concept
    Yaakov Stern
    G H Sergievsky Center, The Taub Institute, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Int Neuropsychol Soc 8:448-60. 2002
    ..Epidemiologic and imaging data that help to develop and support the concept of reserve are presented...
  16. ncbi Cognitive dysfunction in HIV patients despite long-standing suppression of viremia
    Samanta Simioni
    Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    AIDS 24:1243-50. 2010
    ..To determine the prevalence of cognitive complaints and HIV-associated neurocognitive disorders (HANDs) in a cohort of aviremic HIV-positive patients. To evaluate the relevance of the HIV dementia scale to detect HANDs...
  17. ncbi Aging gracefully: compensatory brain activity in high-performing older adults
    Roberto Cabeza
    Center for Cognitive Neurosciences, Duke University, B203 LSRC Building, Durham, North Carolina 27708, USA
    Neuroimage 17:1394-402. 2002
    ....
  18. ncbi Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD
    R A Barkley
    Department of Psychiatry, University of Massachusetts Medical Center, Worcester 01655, USA
    Psychol Bull 121:65-94. 1997
    ..Although the model is promising as a potential theory of self-control and ADHD, far more research is required to evaluate its merits and the many predictions it makes about ADHD...
  19. ncbi The activation of attentional networks
    Jin Fan
    Laboratory of Neuroimaging, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroimage 26:471-9. 2005
    ..Overall, the fMRI results suggest that the functional contrasts within this single task differentially activate three separable anatomical networks related to the components of attention...
  20. ncbi Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
    Adam R Aron
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Neurosci 6:115-6. 2003
  21. ncbi Testing the efficiency and independence of attentional networks
    Jin Fan
    The Sackler Institute for Developmental Psychobiology, Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10002, USA
    J Cogn Neurosci 14:340-7. 2002
    ..The ANT may also serve as an activation task for neuroimaging studies and as a phenotype for the study of the influence of genes on attentional networks...
  22. ncbi Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial
    Nicola T Lautenschlager
    WA Centre for Health and Ageing, University of Western Australia, Melbourne, Australia
    JAMA 300:1027-37. 2008
    ..Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking...
  23. ncbi Neurocognitive deficit in schizophrenia: a quantitative review of the evidence
    R W Heinrichs
    Department of Psychology, York University, Toronto, Ontario, Canada
    Neuropsychology 12:426-45. 1998
    ..The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests...
  24. ncbi An application of prefrontal cortex function theory to cognitive aging
    R L West
    Department of Psychology, University of South Carolina, USA
    Psychol Bull 120:272-92. 1996
    ..I found the frontal lobe hypothesis to perform well, with the exception of an inability to account for age-related declines in item recall and recognition memory, possibly a result of age-related declines in medial temporal function...
  25. ncbi Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children
    Cornelieke Sandrine Hanan Aarnoudse-Moens
    Division of Neonatology, Department of Pediatrics, Erasmus University Medical Centre Sophia Children s Hospital, Rotterdam, Netherlands
    Pediatrics 124:717-28. 2009
    ..We conducted a quantitative meta-analysis of studies published between 1998 and 2008 on academic achievement, behavioral functioning, and EF with the aim of providing aggregated measures of effect size for these outcome domains...
  26. ncbi Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review
    Erik G Willcutt
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    Biol Psychiatry 57:1336-46. 2005
    ..Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD...
  27. ncbi Neuropsychological clustering highlights cognitive differences in young people presenting with depressive symptoms
    Daniel F Hermens
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    J Int Neuropsychol Soc 17:267-76. 2011
    ..Distinct neuropsychological profiling may help to predict later psychiatric outcomes and enhance individually-tailored early intervention strategies...
  28. ncbi Executive function and the frontal lobes: a meta-analytic review
    Julie A Alvarez
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Neuropsychol Rev 16:17-42. 2006
    ..The paper concludes with a discussion of the implications of construing the validity of these neuropsychological tests in anatomical, rather than cognitive and behavioral, terms.
  29. ncbi Improving lesion-symptom mapping
    Chris Rorden
    Department of Communication Sciences and Disorders, University of South Carolina, SC 29208, USA
    J Cogn Neurosci 19:1081-8. 2007
    ..We also developed software to implement these tests (MRIcron), made freely available to the scientific community...
  30. pmc Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory
    Morris Moscovitch
    Department of Psychology, University of Toronto and Rotman Research Institute Baycrest Centre, Ontario, Canada
    J Anat 207:35-66. 2005
    ....
  31. ncbi Executive dysfunction in autism
    Elisabeth L Hill
    Department of Psychology, Goldsmiths College, University of London, Whitehead Building, New Cross, London SE14 6NW, UK
    Trends Cogn Sci 8:26-32. 2004
    ..It is concluded that more detailed research is needed to fractionate the executive system in autism by assessing a wide range of executive functions as well as their neuroanatomical correlates in the same individuals across the lifespan...
  32. ncbi Participation in cognitively stimulating activities and risk of incident Alzheimer disease
    Robert S Wilson
    Rush Alzheimer s Disease Center, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA
    JAMA 287:742-8. 2002
    ..Frequent participation in cognitively stimulating activities has been hypothesized to reduce risk of Alzheimer disease (AD), but prospective data regarding an association are lacking...
  33. ncbi Developmental trajectory of number acuity reveals a severe impairment in developmental dyscalculia
    Manuela Piazza
    INSERM CEA Cognitive Neuroimaging Unit, Gif sur Yvette, France
    Cognition 116:33-41. 2010
    ..These results establish for the first time a clear association between dyscalculia and impaired "number sense", and they may open up new horizons for the early diagnosis and rehabilitation of mathematical learning deficits...
  34. ncbi Practice with sleep makes perfect: sleep-dependent motor skill learning
    Matthew P Walker
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Neuron 35:205-11. 2002
    ..This finding of sleep-dependent motor skill improvement may have important implications for the efficient learning of all skilled actions in humans...
  35. ncbi 'Oops!': performance correlates of everyday attentional failures in traumatic brain injured and normal subjects
    I H Robertson
    Applied Psychology Unit, Rehabilitation Research Group, Addenbrooke s Hospital, Cambridge, U K
    Neuropsychologia 35:747-58. 1997
    ..We also report a highly significant correlation of -0.58 between SART performance and Glasgow Coma Scale Scores in the TBI group...
  36. ncbi Under-recruitment and nonselective recruitment: dissociable neural mechanisms associated with aging
    Jessica M Logan
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Neuron 33:827-40. 2002
    ..The former is reversible and potentially amenable to cognitive training; the latter may reflect a less malleable change associated with cognitive decline in advanced aging...
  37. pmc A meta-analysis of cognitive remediation in schizophrenia
    Susan R McGurk
    Dartmouth Psychiatric Research Center, 105 Pleasant Street, Concord, NH 03301, USA
    Am J Psychiatry 164:1791-802. 2007
    ..This study evaluated the effects of cognitive remediation for improving cognitive performance, symptoms, and psychosocial functioning in schizophrenia...
  38. ncbi Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury
    P Grandjean
    Institute of Community Health, Odense University, Denmark
    Neurotoxicol Teratol 19:417-28. 1997
    ..At approximately 7 years of age, 917 of the children underwent detailed neurobehavioral examination. Neuropsychological tests included Finger Tapping; Hand-Eye Coordination; reaction time on a Continuous Performance Test; Wechsler ..
  39. ncbi Cognitive deficits in depression: possible implications for functional neuropathology
    M P Austin
    Mood Disorders Unit and Department of Liaison Psychiatry, Prince of Wales Hospital, Sydney, Australia
    Br J Psychiatry 178:200-6. 2001
    ..While depression is known to involve a disturbance of mood, movement and cognition, its associated cognitive deficits are frequently viewed as simple epiphenomena of the disorder...
  40. ncbi The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity
    C Randolph
    Department of Neurology, Loyola University Medical Center, Maywood, IL, USA
    J Clin Exp Neuropsychol 20:310-9. 1998
    ..These data suggest that the RBANS is effective at both detecting and characterizing dementia of different etiologies...
  41. ncbi Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions
    A Bechara
    Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Brain 123:2189-202. 2000
    ..This 'myopia for the future' in VM lesion patients persists in the face of severe adverse consequences, i.e. rising future punishment or declining future reward...
  42. pmc Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials
    Patrick J Smith
    Box 3119, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 72:239-52. 2010
    ....
  43. ncbi Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect
    Y Rossetti
    Service de Reeducation Neurologique, Hopital Henry Gabrielle, Hospices Civils de Lyon, France
    Nature 395:166-9. 1998
    ..the visual field to the right were improved on their manual body-midline demonstration and on classical neuropsychological tests. Unlike other physiological manipulations used to improve neglect, this improvement lasted for at least ..
  44. ncbi Altered functional connectivity in early Alzheimer's disease: a resting-state fMRI study
    Kun Wang
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, People s Republic of China
    Hum Brain Mapp 28:967-78. 2007
    ..In addition, the results also suggest that AD may disturb the correlation/anti-correlation effect in the two intrinsically anti-correlated networks...
  45. pmc When does age-related cognitive decline begin?
    Timothy A Salthouse
    Department of Psychology, University of Virginia, Charlottesville, VA 22904 4400, USA
    Neurobiol Aging 30:507-14. 2009
    ....
  46. ncbi Training of working memory in children with ADHD
    Torkel Klingberg
    Department of Neuropediatrics, Karolinska Institute, Stockholm, Sweden
    J Clin Exp Neuropsychol 24:781-91. 2002
    ..The results thus suggest that WM training potentially could be of clinical use for ameliorating the symptoms in ADHD...
  47. ncbi Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study
    Constantine G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    JAMA 288:1475-83. 2002
    ..Dementia and MCI are associated with neuropsychiatric symptoms in clinical samples. Only 2 population-based studies exist of the prevalence of these symptoms in dementia, and none exist for MCI...
  48. pmc Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study
    Henry W Mahncke
    Posit Science Corporation, 225 Bush Street, San Francisco, CA 94104, USA
    Proc Natl Acad Sci U S A 103:12523-8. 2006
    ..This study demonstrates that intensive, plasticity-engaging training can result in an enhancement of cognitive function in normal mature adults...
  49. ncbi Clock-drawing: is it the ideal cognitive screening test?
    K I Shulman
    Department of Psychiatry, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Ontario, Canada
    Int J Geriatr Psychiatry 15:548-61. 2000
    ..This review aims to synthesize the available evidence and assess the value of this screening test according to well-defined criteria...
  50. ncbi Diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease: a review
    Terence C Chua
    Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Randwick, NSW, Australia
    Curr Opin Neurol 21:83-92. 2008
    ..To provide a comprehensive review of diffusion tensor imaging in evaluating microstructural changes in the spectrum of cognitive decline from ageing to Alzheimer's disease, in particular focusing on mild cognitive impairment...
  51. pmc Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited
    Lara Menzies
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neurosci Biobehav Rev 32:525-49. 2008
    ....
  52. ncbi Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD
    B C Dickerson
    Department of Neurology, The Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 65:404-11. 2005
    ..To use fMRI to investigate whether hippocampal and entorhinal activation during learning is altered in the earliest phase of mild cognitive impairment (MCI)...
  53. ncbi Dual tasking, gait rhythmicity, and Parkinson's disease: which aspects of gait are attention demanding?
    Galit Yogev
    Movement Disorders Unit, Neurology Department, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
    Eur J Neurosci 22:1248-56. 2005
    ..Moreover, the associations between executive function and gait variability suggest that a decline in executive function in PD may exacerbate the effects of dual tasking on gait, potentially increasing fall risk...
  54. ncbi Normative data from the CANTAB. I: development of executive function over the lifespan
    Cinzia R De Luca
    Sunshine Hospital and Department of Psychiatry, University of Melbourne, Australia
    J Clin Exp Neuropsychol 25:242-54. 2003
    ..Declines in performance on all tasks were revealed for the 50-64 year old sample, providing support for the vulnerability of executive skills to normal aging...
  55. ncbi On inhibition/disinhibition in developmental psychopathology: views from cognitive and personality psychology and a working inhibition taxonomy
    J T Nigg
    Department of Psychology, Michigan State University, East Lansing 48824 1117, USA
    Psychol Bull 126:220-46. 2000
    ..Such an approach can clarify which inhibition distinctions are correct and which inhibition deficits go with which disorders...
  56. pmc Response inhibition in the stop-signal paradigm
    Frederick Verbruggen
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Trends Cogn Sci 12:418-24. 2008
    ....
  57. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
    ..in a clinically unimpaired elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission tomography (PET) imaging, and its relationship to cognitive function, measured with a battery of neuropsychological tests.
  58. pmc Effects of aerobic exercise on mild cognitive impairment: a controlled trial
    Laura D Baker
    Departments of Psychiatry and BehavioralScience, University of Washington School of Medicine, Seattle, Washington, USA
    Arch Neurol 67:71-9. 2010
    ..To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response...
  59. ncbi Functional specialization within rostral prefrontal cortex (area 10): a meta-analysis
    Sam J Gilbert
    University College London, UK
    J Cogn Neurosci 18:932-48. 2006
    ..These results point to considerable functional segregation within rostral prefrontal cortex...
  60. ncbi Frontal lobes and human memory: insights from functional neuroimaging
    P C Fletcher
    Research Department of Psychiatry, Cambridge University, Addenbrooke s Hospital, Cambridge, UK
    Brain 124:849-81. 2001
    ..We expect that the neuroimaging techniques will provide an important part of this enterprise...
  61. pmc Using imagination to understand the neural basis of episodic memory
    Demis Hassabis
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 27:14365-74. 2007
    ..We suggest that additional brain regions are co-opted into this core network in a task-specific manner to support functions such as episodic memory that may have additional requirements...
  62. ncbi Prediction of psychosis by mismatch negativity
    Mitja Bodatsch
    Department of Psychiatry and Psychotherapy, University of Cologne, Germany
    Biol Psychiatry 69:959-66. 2011
    ..To this aim, mismatch negativity (MMN) was investigated in a sample clinically at high risk, comparing individuals with and without subsequent conversion to psychosis...
  63. ncbi Differential effects of early hippocampal pathology on episodic and semantic memory
    F Vargha-Khadem
    Cognitive Neuroscience Unit, Institute of Child Health, University College London Medical School, Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK
    Science 277:376-80. 1997
    ..The findings provide support for the view that the episodic and semantic components of cognitive memory are partly dissociable, with only the episodic component being fully dependent on the hippocampus...
  64. pmc Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group
    Carmen Simonsen
    Department of Psychology, University of Oslo, 0317 Oslo, Norway
    Schizophr Bull 37:73-83. 2011
    ..We asked whether neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends more on history of psychosis than diagnostic category or subtype...
  65. ncbi Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial
    Richard S E Keefe
    Department of Psychiatry, John Umstead Hospital, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 64:633-47. 2007
    ..The relative effect of the second-generation (atypical) antipsychotic drugs and older agents on neurocognition has not been comprehensively determined...
  66. ncbi Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory
    D I Kaufer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 12:233-9. 2000
    ..The NPI-Q provides a brief, reliable, informant-based assessment of neuropsychiatric symptoms and associated caregiver distress that may be suitable for use in general clinical practice...
  67. ncbi Training of working memory impacts structural connectivity
    Hikaru Takeuchi
    Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Aoba ku, Sendai, Japan
    J Neurosci 30:3297-303. 2010
    ..Observed structural changes may underlie previously reported improvement of working memory capacity, improvement of other cognitive functions, and altered functional activity following working memory training...
  68. ncbi A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD
    J L Chang
    Department of Neurology, University of California San Francisco, CA, USA
    Neurology 65:75-80. 2005
    ..To investigate the patterns of MRI brain atrophy in patients with ALS with and without clinically evident frontotemporal lobar dementia (FTLD) using voxel-based morphometry (VBM)...
  69. ncbi Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism
    Jennifer H Barnett
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 64:137-44. 2008
    ..We conducted a meta-analysis of reported associations between the COMT Val158/108Met polymorphism and measures of memory and executive function...
  70. ncbi Prefrontal cortex and basal ganglia control access to working memory
    Fiona McNab
    Developmental Cognitive Neuroscience, Stockholm Brain Institute, Karolinska Institutet, MR Centrum, Stockholm, Sweden
    Nat Neurosci 11:103-7. 2008
    ....
  71. ncbi Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis
    Sarah T Pendlebury
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Lancet Neurol 8:1006-18. 2009
    ..We undertook this systematic review to assess the heterogeneity in the reported rates and to identify risk factors for pre-stroke and post-stroke dementia...
  72. ncbi Prodromal Alzheimer's disease: successive emergence of the clinical symptoms
    Helene Amieva
    Institut National de la Sante et de la Recherche Medicale, U897, France
    Ann Neurol 64:492-8. 2008
    ..Utilizing the long follow-up of the PAQUID study, we examined the emergence of the first clinical symptoms over a 14-year period of follow-up before the dementia phase of AD...
  73. pmc Aerobic fitness is associated with hippocampal volume in elderly humans
    Kirk I Erickson
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15206, USA
    Hippocampus 19:1030-9. 2009
    ..Our results clearly indicate that higher levels of aerobic fitness are associated with increased hippocampal volume in older humans, which translates to better memory function...
  74. ncbi Leisure activities and the risk of dementia in the elderly
    Joe Verghese
    Einstein Aging Study, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    N Engl J Med 348:2508-16. 2003
    ..It is unclear whether increased participation in leisure activities lowers the risk of dementia or participation in leisure activities declines during the preclinical phase of dementia...
  75. ncbi Neuropsychological performance in adult attention-deficit hyperactivity disorder: meta-analysis of empirical data
    Claudia Schoechlin
    Ludwig Maximilians University, Munich, Germany
    Arch Clin Neuropsychol 20:727-44. 2005
    ..b>Neuropsychological tests are important tools to quantify the attentional and/or cognitive deficits of patients compared to ..
  76. ncbi Functions of the left superior frontal gyrus in humans: a lesion study
    Foucaud du Boisgueheneuc
    Federation de Neurologie, Paris, France
    Brain 129:3315-28. 2006
    ..From a clinical perspective, this study provides new information on the impact of left SFG lesions on cognition that will be of use to neurologists and neurosurgeons...
  77. ncbi Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
    Susheel Vijayraghavan
    Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, Connecticut 06520 8001, USA
    Nat Neurosci 10:376-84. 2007
    ..The evidence for an inverted U at the cellular level in behaving animals promises to bridge in vitro molecular analyses with human cognitive experience...
  78. pmc Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative review
    Naomi A Fineberg
    Department of Psychiatry, National OCDs Specialist Centre, Hertfordshire Partnership NHS Foundation Trust, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UK
    Neuropsychopharmacology 35:591-604. 2010
    ..Targeted application of neurocognitive tasks, receptor-specific neurochemical probes, and brain systems neuroimaging techniques have potential for future research in this field...
  79. ncbi Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications
    Carol Gregory
    Fulbourn Hospital, Cambridge, UK
    Brain 125:752-64. 2002
    ..This study supports the hypothesis that patients with fvFTD, but not those with Alzheimer's disease, are impaired on tests of ToM, and may explain some of the abnormalities in interpersonal behaviour that characterize fvFTD...
  80. ncbi Cognitive dysfunction in Parkinson's disease: the role of frontostriatal circuitry
    Adrian M Owen
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    Neuroscientist 10:525-37. 2004
    ..As a direct result, it has been possible to redefine impairments of executive function in Parkinson's disease more precisely in terms of the specific neuropsychological, neuroanatomical, and psychopharmacological mechanisms involved...
  81. ncbi Safety and cognitive effect of frontal DC brain polarization in healthy individuals
    M B Iyer
    Brain Stimulation Unit and Cognitive Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Neurology 64:872-5. 2005
    ..Activating effects on the frontal lobe might be beneficial for patients with frontal lobe disorders. This phase 1 study tested the safety of frontal DC, including its effects on frontal and other brain functions...
  82. pmc Human medial frontal cortex mediates unconscious inhibition of voluntary action
    Petroc Sumner
    School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, UK
    Neuron 54:697-711. 2007
    ..These findings imply that the SEF and SMA mediate automatic effector-specific suppression of motor plans. This automatic mechanism may contribute to the participation of these areas in the voluntary control of action...
  83. ncbi Perceptual deficits in amnesia: challenging the medial temporal lobe 'mnemonic' view
    Andy C H Lee
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, UK
    Neuropsychologia 43:1-11. 2005
    ..These novel observations imply that the human MTL subserves both perceptual and mnemonic functions, with the hippocampus and perirhinal cortex playing distinct roles in spatial and object discrimination, respectively...
  84. ncbi Sensitivity and specificity of neuropsychological tests for mild cognitive impairment, vascular cognitive impairment and Alzheimer's disease
    C A De Jager
    Department of Pharmacology, University of Oxford, Oxford Project to Investigate Memory and Ageing, Radcliffe Infirmary Trust, Oxford
    Psychol Med 33:1039-50. 2003
    ..We designed a brief comprehensive neuropsychological test battery to help differentiate control subjects from patients with mild cognitive impairment (MCI) and dementia...
  85. ncbi Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials
    Michael Grundman
    Alzheimer s Disease Cooperative Study, Department of Neurosciences, University of California San Diego, 8950 Villa La Jolla Drive, Suite 227, La Jolla, CA 92037, USA
    Arch Neurol 61:59-66. 2004
    ..The Memory Impairment Study (MIS) is a multicenter clinical trial in patients with MCI designed to evaluate whether vitamin E or donepezil is effective at delaying the time to a clinical diagnosis of AD...
  86. ncbi The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort
    Caroline H Williams-Gray
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK
    Brain 132:2958-69. 2009
    ..Our work suggests that the dementing process in Parkinson's disease is predictable and related to tau while frontal-executive dysfunction evolves independently with a more dopaminergic basis and better prognosis...
  87. ncbi Computerized working memory training improves function in adolescents born at extremely low birth weight
    Gro C C Løhaugen
    Department of Pediatrics and Rehabilitation, Sørlandet Hospital, Arendal, Norway
    J Pediatr 158:555-561.e4. 2011
    ..To evaluate the effect of a computerized working memory training program on both trained and non-trained verbal aspects of working memory and executive and memory functions in extremely low birth weight (ELBW; <1000 g) infants...
  88. ncbi Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Vic, Australia
    J Affect Disord 113:1-20. 2009
    ..Our aim was to delineate neuropsychological deficits related to genetic susceptibility, illness process and iatrogenic factors in bipolar disorder (BD)...
  89. ncbi Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis
    R A Dineen
    Department of Academic Radiology, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Brain 132:239-49. 2009
    ..This suggests that TBSS reveals functionally relevant tract injury underlying cognitive dysfunction in patients with multiple sclerosis...
  90. ncbi Elevated body mass index is associated with executive dysfunction in otherwise healthy adults
    John Gunstad
    Department of Psychology, Kent Hall, Kent State University, Kent, OH 44242, USA
    Compr Psychiatry 48:57-61. 2007
    ..Further research is needed to identify the etiology of these deficits and whether they resolve after weight loss...
  91. ncbi The human medial temporal lobe processes online representations of complex objects
    Morgan D Barense
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, United Kingdom
    Neuropsychologia 45:2963-74. 2007
    ....
  92. ncbi Long-lasting amelioration of visuospatial neglect by prism adaptation
    Francesca Frassinetti
    Dipartimento di Psicologia, Universita degli Studi di Bologna, Bologna, Italy
    Brain 125:608-23. 2002
    ..In conclusion, these findings show that prism adaptation is a productive way of achieving long-lasting improvements in neglect treatment...
  93. ncbi The role of cingulate cortex in the detection of errors with and without awareness: a high-density electrical mapping study
    Redmond G O'Connell
    Department of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Eur J Neurosci 25:2571-9. 2007
    ..These findings may be particularly important in the context of clinical studies in which a proper understanding of self-monitoring deficits requires an explicit measurement of error awareness...
  94. ncbi Influence of the COMT genotype on working memory and brain activity changes during development
    Iroise Dumontheil
    Neuroscience Department, Karolinska Institutet, Retzius vag 8, Stockholm, Sweden
    Biol Psychiatry 70:222-9. 2011
    ..Dopaminergic system changes during adolescence may lead to a reduction of basal dopamine levels, potentially affecting Met allele benefits during development...
  95. ncbi Neurocognitive profiles in bipolar I and bipolar II disorder: differences in pattern and magnitude of dysfunction
    Carmen Simonsen
    Department of Psychiatry, Ulleval University Hospital, and Institute of Psychology, University of Oslo, Oslo, Norway
    Bipolar Disord 10:245-55. 2008
    ..The aim of this study was to examine whether patients with bipolar I and bipolar II disorder have different neurocognitive profiles...
  96. ncbi The gateway hypothesis of rostral prefrontal cortex (area 10) function
    Paul W Burgess
    Institute of Cognitive Neuroscience and Psychology Department, University College London, London, WC1E 6BT, UK
    Trends Cogn Sci 11:290-8. 2007
    ..e. the 'thoughts in our head'). In this way, investigations into the functions of rostral PFC will reveal key new insights into how human and non-human mental abilities differ...
  97. ncbi Constructive episodic simulation of the future and the past: distinct subsystems of a core brain network mediate imagining and remembering
    Donna Rose Addis
    Department of Psychology, The University of Auckland, New Zealand
    Neuropsychologia 47:2222-38. 2009
    ....
  98. ncbi Neuroanatomy of hemispatial neglect and its functional components: a study using voxel-based lesion-symptom mapping
    Vincent Verdon
    Department of Psychology, University of Geneva, Geneva, Switzerland
    Brain 133:880-94. 2010
    ..study of 80 patients with a focal right hemisphere stroke, who were examined by a series of neuropsychological tests assessing different clinical manifestations of neglect...
  99. ncbi Identification of separable cognitive factors in schizophrenia
    Keith H Nuechterlein
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, USA
    Schizophr Res 72:29-39. 2004
    ..These separable cognitive dimensions also have broader relevance to future research aimed at understanding the nature and structure of core cognitive deficits in schizophrenia...
  100. ncbi Spatial memory deficits in patients with lesions to the right hippocampus and to the right parahippocampal cortex
    V D Bohbot
    Psychology Department, University of Arizona, Tucson, 85724, USA
    Neuropsychologia 36:1217-38. 1998
    ..Patients with lesions to the right parahippocampal cortex were impaired on this task with a 30 min delay, suggesting that the parahippocampal cortex itself may play an important role in spatial memory...
  101. ncbi Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients
    L S Rasmussen
    Department of Anaesthesia, Center of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 47:260-6. 2003
    ..We hypothesized that the incidence of POCD would be less with regional anaesthesia rather than general...

Research Grants74

  1. Informed Consent in People with Multiple Sclerosis
    Michael Basso; Fiscal Year: 2007
    ..Individuals with M.S. and control participants will be administered a battery of standard neuropsychological tests that will emphasize executive function, memory, attention, and expressive and receptive language...
  2. COGNITIVE AND CEREBROVASCULAR SEQUELAE OF HYPERTENSION
    J Jennings; Fiscal Year: 2004
    ..We and others have found that patients with essential hypertension have impaired performance on neuropsychological tests relative to age-matched controls...
  3. HEPATIC ENCEPHALOPATHY--NEUROPSYCHOLOGY & NEUROCHEMISTRY
    Michael Thomas; Fiscal Year: 2001
    ..Although neuropsychological tests are the current standard for diagnosing SHE, the results are non-specific and reveal little about the ..
  4. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..Ante-mortem diagnosis of Alzheimer's based on neuropsychological tests are inconclusive at early stages of the disease and clinical PET imaging with [18F]FDG is suboptimal for ..
  5. NEURAL RESPONSE TO INSULIN RESISTANCE TREATMENTS
    JASON J HASSENSTAB; Fiscal Year: 2013
    ..The proposed study will use fMRI, biomarkers of metabolic functioning, and neuropsychological tests to examine changes in cognition and brain response in obese and sedentary middle aged adults undergoing ..
  6. 18F-Mefway PET for Human Aging and Alzheimer's Disease
    Jogeshwar Mukherjee; Fiscal Year: 2013
    ..18F-Mefway will be evaluated in well-characterized groups of control, MCI and AD subjects and results will be correlated with clinical outcome measures of 18F-FDG, MRI and neuropsychological tests.
  7. Brain Development, Behavior and Cognition in Pre- and Postnatal Cocaine Exposure
    Tamara Duckworth Warner; Fiscal Year: 2010
    ..of novel, cutting edge, state-of-the-art structural image analysis tools in conjunction with sophisticated neuropsychological tests to better understand the effects of cocaine on the structure and function of the developing human brain.
  8. Diabetes, Cognition and the Brain
    Antonio Convit; Fiscal Year: 2012
    ..goal we will measure cognition (including memory and frontal lobe measures of performance) with standard neuropsychological tests, hippocampal volumes with validated and reliable MRI- based methods, and cerebral vascular reactivity ..
  9. A Follow-up of Children Enrolled in the Management of Myelomeningocele Study
    ELIZABETH ANN THOM; Fiscal Year: 2013
    ..Cognitive function will be measured by a battery of neuropsychological tests. Motor level and function will be assessed by physical examination...
  10. fMRI and Cognition in Adolescent Cannabis Users
    Susan F Tapert; Fiscal Year: 2010
    ..of 90 adolescents recruited in project R21 DA15228 (PI: Tapert), and follow these 168 teens with the same neuropsychological tests, functional magnetic resonance imaging (FMRI;working memory, inhibition, and learning tasks), MRI (to ..
  11. Amyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down Syndrome
    Linda D Nelson; Fiscal Year: 2010
    ..Comparative neuropsychological tests with proven validity for people suffering from severe levels of cognitive impairment (e.g...
  12. Randomized Trial of IFCBT-HIVPI to Prevent HIV Among Non-Injection Drug Users
    William W Latimer; Fiscal Year: 2013
    ..An assessment battery comprised of a standardized interview on HIV risk behavior, neuropsychological tests, tools to assess attitudes and behavior change skills targeted by IFCBT-HIVPI, drug and STI urine testing,..
  13. GABA-A alpha5 cognitive enhancers: pharmacology and neuropsychology in macaques
    Nancy A Ator; Fiscal Year: 2011
    ....
  14. Ecological Momentary Assessment of Functioning in Schizophrenia
    Eric L Granholm; Fiscal Year: 2013
    ..The success of these efforts could ultimately lead to reduced disability in people with schizophrenia, which would have significant impact on patients and families, as well as broader societal and economic impact. ..
  15. PIB binding, hypometabolism, apathy and executive dysfunction in MCI and AD
    GAD ASHER MARSHALL; Fiscal Year: 2013
    ..function, global function, functional assessments, behavioral assessments focusing on apathy, and neuropsychological tests focusing on executive function...
  16. Phase 2 Study of Glycomacropeptide vs. Amino Acid Diet for the Management of PKU
    Denise M Ney; Fiscal Year: 2013
    ..assessed by food records, acceptability assessed by questionnaires, and cognitive function assessed by neuropsychological tests. The investigators expect that compared to the usual AA diet, the GMP diet will reduce plasma phe levels ..
  17. Imaging the Development of Memory Strategies in Aging
    Cheryl J Aine; Fiscal Year: 2012
    ..function with and without distracters, along with diffusion tensor imaging (DTI), MR morphometry, and neuropsychological tests to investigate links between: 1) WM integrity and system connectivity which are necessary for the ..
  18. Regional Brain Manganese Accumulation and Functional Consequences in Welders
    Xuemei Huang; Fiscal Year: 2013
    ..fitters) with both retrospective and prospective environmental exposure measurements, neuropsychological tests, blood metal (Fe and Mn) assessment, and state-of-the-art MRI estimates of both Mn (with rapid T1 mapping)..
  19. fMRI and Cognition in Youth at Risk for Alcoholism
    Susan F Tapert; Fiscal Year: 2013
    ..Pilot analyses will begin to look at normalization of these neural abnormalities, as some young adults transition out of heavy drinking. ..
  20. Characterizing Two Distinct ADHD Neurobiologies with fMRI
    Michael C Stevens; Fiscal Year: 2012
    ..abstract_text> ..
  21. Vascular Risk and Cognition in a Multi-ethnic Cohort
    Clinton B Wright; Fiscal Year: 2013
    ..factors and inflammatory markers is related to specific cognitive domains using a sensitive battery of neuropsychological tests. Conventional and novel risk factors will include cardiac diseases, hypertension and blood pressure, ..
  22. Mild Cognitive Impairment: Cerebrovascular Dysfunction and Exercise Training
    Rong Zhang; Fiscal Year: 2012
    ..Cognitive function will be assessed using a comprehensive battery of neuropsychological tests focused on the executive and memory function...
  23. COGNITIVE BENEFITS OF TREATING SLEEP APNEA IN DEMENTIA
    Sonia Ancoli-Israel; Fiscal Year: 2011
    ..The long-term goal of this line of research is to find a new approach that might improve the quality of life, delay dementia, and reduce caregiver stress. ..
  24. NEUROPHYSIOLOGICAL ATTENTION MULTIPLEXING TEST
    ALAN S GEVINS; Fiscal Year: 2010
    ..Current static "frontal executive system" task derived from traditional paper and pencil neuropsychological tests have a number of limitations, foremost the inability to adapt in difficulty and provide a consistently ..
  25. Neuroanatomical Substrates of Aging & Cognitive Decline
    Gene E Alexander; Fiscal Year: 2010
    ..and baseline and two year follow up assessments of cognitive function using a battery of standardized neuropsychological tests. We will test hypotheses using regional univariate and multivariate network analysis methods with voxel-..
  26. A Multi-Site Trial of a Cognitive Rehabilitation Intervention for Persons with MS
    Alexa K Stuifbergen; Fiscal Year: 2013
    ..and feasible and had medium to large effects on the use of compensatory strategies and performance on neuropsychological tests of verbal memory...
  27. Videoconference CBT for Rural Breast Cancer Survivors with Cognitive Complaints
    Robert J Ferguson; Fiscal Year: 2012
    ..on quality of life, anxiety about cognitive problems, functional wellbeing, and on brief telephone-based neuropsychological tests of memory at 3 time points: pre-treatment, post-treatment and 2-month follow-up...
  28. Adapt Integrated Family CBT into HIV Prevention Intervention for Pregnant Women
    William Latimer; Fiscal Year: 2009
    ..The pilot test includes standardized interviews on HIV risk behavior and psychiatric disorders, neuropsychological tests, self-report tools, urine drug testing, and serologic tests of HIV and hepatitis A, B, and C viruses ..
  29. PET, APOE &the Preclinical Course of Alzheimer's Disease
    ERIC MICHAEL REIMAN; Fiscal Year: 2012
    ..measurements of gray matter density, cortical thickness and whole brain volume, clinical ratings and neuropsychological tests every two years in 35 54 homozygotes, 50 54 heterozygotes, and 75 54 non-carriers, further characterize ..
  30. Is mental disorder a preventable cause of age-related disease? The Dunedin Study.
    TERRIE EDITH MOFFITT; Fiscal Year: 2013
    ..measures of sub-clinical health status that are known predictors of age-related diseases in later life: neuropsychological tests of memory and executive functions, the metabolic syndrome, immunological biomarkers, and shortened ..
  31. US-France Research Collaboration on Neuroimaging Studies of Alcoholism
    EDITH VIONI SULLIVAN; Fiscal Year: 2012
    ..diffusion tensor imaging (DTI);and selective brain functions, measured with functional MRI (fMRI) and neuropsychological tests of component processes of cognition, memory, and motor abilities...
  32. Mechanisms of Spatial Cognitive Impairment in Neurodegenerative Disease
    KATHERINE LAUREL POSSIN; Fiscal Year: 2013
    ..Joel Kramer, a neuropsychologist who is an international leader in the development of neuropsychological tests;Dr...
  33. Health Effects of PCB Exposure from Contaminated Fish
    Susan L Schantz; Fiscal Year: 2010
    ..Children will be assessed on a battery of neuropsychological tests that assess specific aspects of executive function including working memory, cognitive flexibility, ..
  34. Imaging Brain and Movement in ASD
    Jeanne Townsend; Fiscal Year: 2010
    ..Participants will complete a series of neuropsychological tests, functional assessments, MR and Diffusion Tensor Imaging and MoBI brain and movement imaging...
  35. Motor Control and Cerebellar Maturation in Autism
    Matthew W Mosconi; Fiscal Year: 2013
    ..b>Neuropsychological tests of motor skill, as well as clinical neurological examinations of motor function, also will be ..
  36. Role of English Fluency in Spanish Neuropsychological Performance
    Paula Suarez; Fiscal Year: 2010
    ....
  37. QUESTIONABLE DEMENTIA: COURSE AND PREDICTORS OF OUTCOME
    Davangere P Devanand; Fiscal Year: 2012
    ..Accurate prediction of MCI conversion to AD will help identify patients who need early treatment, facilitate patient/family planning for their own future, and improve patient selection for clinical trials. ..
  38. Low-Burden Tools for Improving Prediction and Diagnosis of Cognitive Impairment.
    VALERIE FRANCES REYNA; Fiscal Year: 2010
    ..g., the ApoE genotype), behavioral markers of impairment (e.g., neuropsychological tests), and clinical diagnoses of impairment...
  39. Perceptual, Cognitive, and Motor Rigidity in Parkinson's Disease
    Mirella Díaz-Santos; Fiscal Year: 2013
    ..The participants will be assessed for cognitive rigidity (neuropsychological tests of executive function including perseveration), motor rigidity (gait measures of relative phase between ..
  40. Qualitative analysis of cognitive functioning of prostate cancer survivors on ADT
    LISA MARIA WU; Fiscal Year: 2013
    ..there is evidence that ADT may be associated with objectively-assessed cognitive impairment (assessed by neuropsychological tests), but there are also studies that note minimal or no impairments in ADT patients compared with healthy ..
  41. Complicated Grief in Older Adults: Physiological Substrates of Emotion Regulation
    MARY FRANCES O'CONNOR; Fiscal Year: 2011
    ..The proposed research will assess neural activation, immune markers, and neuropsychological tests of attention and emotion regulation in older adults...
  42. Exercise &Overweight Children's Cognition
    Phillip D Tomporowski; Fiscal Year: 2012
    ..abstract_text> ..
  43. Predicting Placebo Responses Across Disease States
    Jon Kar Zubieta; Fiscal Year: 2012
    ..variations in neurotransmitter systems and circuits involved will then be modeled by a combination of neuropsychological tests and the presence of common genetic polymorphisms regulating those regional networks...
  44. PAP adherence and real-world driving safety in OSA
    Matthew Rizzo; Fiscal Year: 2013
    ..team of experts at UI will comprehensively assess 1) cognitive functions using standardized neuropsychological tests;2) physiologic indices of disease severity from laboratory based polysomnography (PSG);3) extended ..
  45. Loneliness and biomarkers of Alzheimer's disease in clinically normal elderly
    Nancy J Donovan; Fiscal Year: 2013
    ..The goal of this study is to determine whether measures of loneliness are associated with sensitive neuropsychological tests and multi-modal neuroimaging biomarkers of preclinical AD in a cohort of clinically normal (CN) older ..
  46. Mnemonic Processing Deficits in Older Adults at Risk for Alzheimer's Disease
    Paul E Gilbert; Fiscal Year: 2013
    ..Specific Aim 1), examine relationships between performance on the experiments and standardized neuropsychological tests (Specific Aim 2), and characterize the performance of older adults, with and without the APOE E4 allele ..
  47. Imaging the effects of androgen deprivation therapy on cognitive functions in pat
    HERTA HUEY AN CHAO; Fiscal Year: 2010
    ..Changes in cognitive performance have been reported but results of previous studies using neuropsychological tests alone have been equivocal...
  48. STRESS AND INFLAMMATION IN THE PATHOPHYSIOLOGY OF LATE-LIFE DEPRESSION
    Yvette I Sheline; Fiscal Year: 2013
    ..n=50), and assess participants pre- and post-treatment with peripheral and central cytokine levels, neuropsychological tests and brain resting state functional connectivity...
  49. Daily Functioning, Cognition, and Caregiver Burden in MCI Patients
    LALEH JILL RAZANI; Fiscal Year: 2013
    ..abstract_text> ..
  50. Molecular Studies of Cognition in Chronic Alcoholism
    Jay W Pettegrew; Fiscal Year: 2010
    ..b>Neuropsychological tests are used to assess abstract reasoning and problem solving, memory, attention, language, spatial abilities,..
  51. Pilot Explorations of Neurofeedback Issues in ADHD
    L Eugene Arnold; Fiscal Year: 2010
    ..will include measures of symptoms, functional impairment, academic performance/achievement, and neuropsychological tests of attention, vigilance, and executive functioning...
  52. 2/2-Combined Oxytocin and CBSST for Social Function in People with Schizophrenia
    Eric L Granholm; Fiscal Year: 2013
    ..The study will provide critical preliminary data on the clinical utility of oxytocin + CBSST for the improvement of social function in people with schizophrenia. ..
  53. A brief iPad-based screening measure for HIV-associated neurocognitive disorders
    JOAN M SEVERSON; Fiscal Year: 2013
    ..collected in the HIV+ participants, as well as examine the relationship between the iPad tests and common neuropsychological tests in individuals without brain dysfunction...
  54. MRI Structural and Functional Connectivity Changes in Temporal Lobe Epilepsy
    Victoria L Morgan; Fiscal Year: 2013
    ..Furthermore, the proposed approach may be expanded and applied to other forms of focal epilepsy in both adults and children to increase the utilization of surgical treatment for these patients. ..
  55. 1/2-Combined Oxytocin and CBSST for Social Function in People with Schizophrenia
    Robert W Buchanan; Fiscal Year: 2013
    ..The study will provide critical preliminary data on the clinical utility of oxytocin + CBSST for the improvement of social function in people with schizophrenia. ..
  56. Vascular Depression: Longitudinal Followup
    Yvette I Sheline; Fiscal Year: 2010
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  57. Vascular Depression: Longitudinal Changes
    Warren D Taylor; Fiscal Year: 2010
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  58. Assessing Brain Function and Engagement in Older Adults
    Izhak Shafran; Fiscal Year: 2013
    ..Shafran's expertise in spoken language technology, a large clinical cohort monitored with extensive neuropsychological tests, an infrastructure for evaluating new technology, expertise in clinical psychology and epidemiology ..
  59. Neuropsychological Screening of OEF/OIF Veterans in VA Primary Care
    Karen H Seal; Fiscal Year: 2013
    ..If successful, results from this study may be applied in translation to the VA primary care setting to improve VA's ability to efficiently and accurately assess and triage OEF/OIF veterans. ..
  60. ENGLISH AND SPANISH ASSESSMENT OF COGNITION IN ELDERLY
    Dan M Mungas; Fiscal Year: 2012
    ..b>Neuropsychological tests of cognitive abilities have long been used to measure changes in cognition related to diseases like ..
  61. Neurocognitive Deficits, Substance Use, and HIV Risk Behavior
    Sarit A Golub; Fiscal Year: 2010
    ..A better understanding how of neurocognitive factors impact substance use and HIV risk is critical to the development, implementation, and adaptation of effective HIV prevention efforts. ..
  62. EFFECTS OF OMEGA-3 FATTY ACIDS ON COGNITIVE PERFORMANCE
    Matthew F Muldoon; Fiscal Year: 2012
    ..This new, secondary outcome would entail administration of a battery of neuropsychological tests assessing working and general memory, psychomotor speed, attention and executive function at baseline and ..
  63. Visuospatial Rehabilitation after Right Hemisphere Stroke
    Peii Chen; Fiscal Year: 2010
    ..The significance of the proposed research is to establish effective treatments for visuospatial deficits in right hemisphere stroke survivors so that functional disability and cost of rehabilitation care will be reduced. ..
  64. Toward using comprehensive decision-making models in neuropsychological testing
    Roger Ratcliff; Fiscal Year: 2013
    ..The eventual goal of the proposed research is the development of neuropsychological tests that can be used to assess the impacts on cognition of, for example, concussion, aging, and chemotherapy...
  65. Aging Brain, Cognition, and Dopamine
    William J Jagust; Fiscal Year: 2013
    ..and that greater atrophy will be associated with higher dopamine synthesis and poorer performance on neuropsychological tests reflecting executive function...
  66. Neuropsychological & Thyroid Effects of Perfluorinated Compounds in Older Adults
    Edward Fitzgerald; Fiscal Year: 2009
    ....
  67. COGNITIVE AND NEUROIMAGING STUDY OF SICKLE CELL ANEMIA
    Elias Melhem; Fiscal Year: 2001
    ..The latter in combination with TCD studies will also elucidate the relationship between proximal characteristics observed by TCD and true end organ perfusion outlined by MR. ..
  68. DENTAL AMALGAMS AND NEUROPSYCHOLOGICAL FUNCTION
    Pam Factor Litvak; Fiscal Year: 1999
    ..Occupational exposure also is associated with deficits in neuropsychological tests of memory and visuospatial ability and increased reports of subjective symptoms and disturbed mood...
  69. EARLY ABUSE AND CORTICOLIMBIC DEVELOPMENT
    Martin Teicher; Fiscal Year: 1999
    ..b>Neuropsychological tests will assess for left vs right hemisphere functional impairment...
  70. HIV Dementia and Sensory Neuropathy in Uganda
    Ned Sacktor; Fiscal Year: 2009
    ....
  71. AIDS DEMENTIA--MOLECULAR AND CELLULAR MECHANISMS
    Floyd Bloom; Fiscal Year: 2000
    ..In addition, these studies may illuminate other unexplained aspects of fundamental neuronal-glial-immune system interaction, the nature of brain resident microglia, and the basis for neuropsychiatric disorders of unknown origin. ..
  72. Effects of Prenatal Nutrition on Developmental Outcomes in the the Juvenile Baboo
    THAD BARTLETT; Fiscal Year: 2009
    ....
  73. STN STIMULATION--DA TRANSPORTERS & OUTCOME IN PARKINSON'
    Andrew Newberg; Fiscal Year: 2004
    ..Long-term outcome in each of these groups will be assessed with neuropsychological tests, clinical rating scales administered by research neurologists, and repeated measurements of dopamine ..
  74. Early brain development after prenatal "Ice" exposure: A Longitudinal MR study
    Linda Chang; Fiscal Year: 2009
    ..brain metabolite abnormalities on proton MR spectroscopy (1H MRS), along with decreased performance on neuropsychological tests. Our preliminary data also suggest that these children do not show appropriate age-related increases in ..