mental status schedule

Summary

Summary: Standardized clinical interview used to assess current psychopathology by scaling patient responses to the questions.

Top Publications

  1. ncbi Cognitive and psychopathologic response to rivastigmine in dementia with Lewy bodies compared to Alzheimer's disease: a case control study
    Luca Rozzini
    Department of Neurology, University of Brescia, Italy
    Am J Alzheimers Dis Other Demen 22:42-7. 2007
  2. pmc Detecting dementia with the mini-mental state examination in highly educated individuals
    Sid E O'Bryant
    Department of Neuropsychiatry and Behavioral Science, Texas Tech University Health Sciences Center, 3601 4th St, STOP 8321, Lubbock, TX 79430, USA
    Arch Neurol 65:963-7. 2008
  3. pmc Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
    O L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 80:600-7. 2009
  4. ncbi The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke
    Yanhong Dong
    Department of Medicine, National University Health System, Singapore
    J Neurol Sci 299:15-8. 2010
  5. ncbi Corpus callosum and cingulum tractography in Parkinson's disease
    Katie Wiltshire
    Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
    Can J Neurol Sci 37:595-600. 2010
  6. ncbi Montreal cognitive assessment in detecting cognitive impairment in Chinese elderly individuals: a population-based study
    Jihui Lu
    Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, People s Republic of China
    J Geriatr Psychiatry Neurol 24:184-90. 2011
  7. ncbi Cognitive and functional decline in adults aged 75 and older
    Sandra A Black
    Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore 21201, USA
    J Am Geriatr Soc 50:1978-86. 2002
  8. ncbi Prolonged activation EEG differentiates dementia with and without delirium in frail elderly patients
    C Thomas
    Centre for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany
    J Neurol Neurosurg Psychiatry 79:119-25. 2008
  9. ncbi Restrictions of the Mini-Mental State Examination in acute stroke
    G M S Nys
    Psychological Laboratory, Helmholtz Institute, Utrecht University, Heidelberglaan 2, 3584 CS Utrecht, The Netherlands
    Arch Clin Neuropsychol 20:623-9. 2005
  10. ncbi Brief screening for mild cognitive impairment in elderly outpatient clinic: validation of the Korean version of the Montreal Cognitive Assessment
    Jun Young Lee
    Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Boramae Hospital, Seoul, South Korea benji snu ac kr
    J Geriatr Psychiatry Neurol 21:104-10. 2008

Research Grants

  1. Dyspraxia and Autonomic Control in Very Early AD
    Donald Royall; Fiscal Year: 2004
  2. VAS-COG 2007
    Donald Royall; Fiscal Year: 2007
  3. Insular AD Pathology and Autonomic Function
    Donald Royall; Fiscal Year: 2006
  4. Neurogenetics & Mild Cognitive Impairment
    Angela Jefferson; Fiscal Year: 2007
  5. Sex Hormones, Related Polymorphisms & Cognitive Decline
    Kristine Yaffe; Fiscal Year: 2006
  6. MCI & decisional capacity to provide informed consent
    Angela Jefferson; Fiscal Year: 2007
  7. Cardiovascular disease and neurocognition in the elderly
    Angela Jefferson; Fiscal Year: 2004
  8. Metabolic Syndrome and Cognitive Impairment
    Kristine Yaffe; Fiscal Year: 2005
  9. ESTROGEN COMPOUNDS, COGNITION & DEMENTIA IN OLDER WOMEN
    Kristine Yaffe; Fiscal Year: 2002
  10. AGE RELATED NEURODEGENERATIVE DISEASES IN MICRONESIA
    Douglas Galasko; Fiscal Year: 2006

Detail Information

Publications239 found, 100 shown here

  1. ncbi Cognitive and psychopathologic response to rivastigmine in dementia with Lewy bodies compared to Alzheimer's disease: a case control study
    Luca Rozzini
    Department of Neurology, University of Brescia, Italy
    Am J Alzheimers Dis Other Demen 22:42-7. 2007
    ..These findings support the view that ChEIs should be considered a first-line treatment of the cognitive and psycho-behavioral symptoms of both AD and DLB...
  2. pmc Detecting dementia with the mini-mental state examination in highly educated individuals
    Sid E O'Bryant
    Department of Neuropsychiatry and Behavioral Science, Texas Tech University Health Sciences Center, 3601 4th St, STOP 8321, Lubbock, TX 79430, USA
    Arch Neurol 65:963-7. 2008
    ..To evaluate the utility of Mini-Mental State Examination (MMSE) scores in detecting cognitive dysfunction in a sample of highly educated individuals...
  3. pmc Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
    O L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 80:600-7. 2009
    ..There are no long-term studies of the effects of memantine in combination with ChEIs use in Alzheimer disease (AD). This study was conducted to examine the effects of ChEIs and memantine on time to death and time to NH admission...
  4. ncbi The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke
    Yanhong Dong
    Department of Medicine, National University Health System, Singapore
    J Neurol Sci 299:15-8. 2010
    ..The Montreal Cognitive Assessment (MoCA) was designed to be more sensitive to such deficits and may therefore be a superior screening instrument for VCIND...
  5. ncbi Corpus callosum and cingulum tractography in Parkinson's disease
    Katie Wiltshire
    Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
    Can J Neurol Sci 37:595-600. 2010
    ..Diffusion tensor imaging is a quantitative imaging method sensitive to the micro-structure of white matter tracts...
  6. ncbi Montreal cognitive assessment in detecting cognitive impairment in Chinese elderly individuals: a population-based study
    Jihui Lu
    Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, People s Republic of China
    J Geriatr Psychiatry Neurol 24:184-90. 2011
    ..5% for MCI and 96.9% for dementia, and the specificity for identifying CN was 82.5%. These indicate that with optimal cutoffs, the MoCA is valid to screen for cognitive impairment in elderly Chinese living in communities...
  7. ncbi Cognitive and functional decline in adults aged 75 and older
    Sandra A Black
    Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore 21201, USA
    J Am Geriatr Soc 50:1978-86. 2002
    ....
  8. ncbi Prolonged activation EEG differentiates dementia with and without delirium in frail elderly patients
    C Thomas
    Centre for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany
    J Neurol Neurosurg Psychiatry 79:119-25. 2008
    ....
  9. ncbi Restrictions of the Mini-Mental State Examination in acute stroke
    G M S Nys
    Psychological Laboratory, Helmholtz Institute, Utrecht University, Heidelberglaan 2, 3584 CS Utrecht, The Netherlands
    Arch Clin Neuropsychol 20:623-9. 2005
    ..67; p = 0.13). No optimum MMSE cut-off value could be identified. The MMSE is particularly insensitive to impairments in abstract reasoning, executive functioning, and visual perception/construction...
  10. ncbi Brief screening for mild cognitive impairment in elderly outpatient clinic: validation of the Korean version of the Montreal Cognitive Assessment
    Jun Young Lee
    Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Boramae Hospital, Seoul, South Korea benji snu ac kr
    J Geriatr Psychiatry Neurol 21:104-10. 2008
    ..Internal consistency and test-retest reliability were good. The results obtained show that the MoCA-K is brief, reliable, and suitable for use as a screening tool to screen MCI patients in elderly outpatient clinic settings...
  11. ncbi The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons
    M N Haan
    Department of Epidemiology and Preventive Medicine, University of California, School of Medicine, Davis 95616, USA
    JAMA 282:40-6. 1999
    ..These risks may be modified by gene-environment interactions between apolipoprotein E (APOE) genotype and CVD risk factors or subclinical CVD...
  12. pmc Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial
    Tali Cukierman-Yaffe
    Gertner Institute for Epidemiology and Health Policy Research, Endocrinology Institute Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Diabetes Care 32:221-6. 2009
    ..This was explored using baseline cognitive measures collected in the ongoing Memory in Diabetes (MIND) substudy of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial...
  13. ncbi Cognitive functioning after stroke: a one-year follow-up study
    Sascha M C Rasquin
    Department of Psychiatry and Neuropsychology, University Hospital Maastricht, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 18:138-44. 2004
    ..Performance on almost all cognitive tests was improved 6 and 12 months after stroke. Thus, while the frequency of post-stroke dementia is low, the frequency of post-stroke MCI is high, but improvement of cognitive function is possible...
  14. ncbi Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree?
    Fiona E Matthews
    Medical Resarch Council Biostatistics Unit, Institute of Public Health, Cambridge, United Kindom
    J Am Geriatr Soc 56:1424-33. 2008
    ..To determine the 2-year outcome from 16 different current classifications of mild cognitive impairment (MCI) in a population-based sample...
  15. ncbi The Short Cognitive Performance Test (SKT): a preliminary study of its psychometric properties in Brazil
    Mariana K Flaks
    Laboratory of Neuroscience, Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Int Psychogeriatr 18:121-33. 2006
    ....
  16. ncbi Different perception of cognitive impairment, behavioral disturbances, and functional disabilities between persons with mild cognitive impairment and mild Alzheimer's disease and their caregivers
    M L Onor
    Department of Clinical, Morphological and Technological Sciences, U C O of Clinical Psychiatry, University of Trieste, Italy
    Am J Alzheimers Dis Other Demen 21:333-8. 2006
    ..The group with MCI or mild AD underestimated their deficits, which were considered serious and disabling by their caregivers...
  17. ncbi Limitations of the Mini-Mental State Examination for screening dementia in a community with low socioeconomic status: results from the Sao Paulo Ageing & Health Study
    Marcia Scazufca
    Department and Institute of Psychiatry, LIM 23, Faculty of Medicine, University of Sao Paulo, R Dr Ovidio Pires de Campos 785, Sao Paulo 05403 010, Brazil
    Eur Arch Psychiatry Clin Neurosci 259:8-15. 2009
    ..The authors investigated the psychometric properties of the MMSE in a community-based sample of older Brazilians...
  18. ncbi Mini-Mental Status Examination: a short form of MMSE was as accurate as the original MMSE in predicting dementia
    Kirsten Schultz-Larsen
    Center for Elder Research, Øster Søgade 18, 2, DK 1357 Copenhagen K, Denmark
    J Clin Epidemiol 60:260-7. 2007
    ..A specific purpose was to determine whether an abbreviated version would be as accurate as the original MMSE in predicting dementia...
  19. ncbi Family caregivers' subjective experiences of satisfaction in dementia care: aspects of burden, subjective health and sense of coherence
    Signe Andrén
    Division of Geriatric Medicine, Department of Community Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    Scand J Caring Sci 19:157-68. 2005
    ..The caregiver can perceive both moderate burden and great satisfaction at the same time, and further studies may help to broaden our understanding of how we can reduce the degree of burden whilst increasing the sense of satisfaction...
  20. ncbi Use of the QOL-AD for measuring quality of life in people with severe dementia--the LASER-AD study
    Juanita Hoe
    Centre for Ageing and Mental Health Sciences, Department of Mental Health Sciences, University College London, Archway Campus, Holborn Union Building, Highgate Hill, London N19 5LW, UK
    Age Ageing 34:130-5. 2005
    ..It is known that people with mild to moderate dementia can provide valid assessments of their own QOL, but it is unclear whether these instruments are useful in those with severe dementia...
  21. pmc Reading disorders in primary progressive aphasia: a behavioral and neuroimaging study
    S M Brambati
    Department of Neurology, UCSF, San Francisco, CA 94143 1207, United States
    Neuropsychologia 47:1893-900. 2009
    ..These results suggest that exception and pseudo-word reading not only rely upon different language mechanisms selectively damaged in PPA, but also that these processes are sustained by separate brain structures...
  22. ncbi Detection of MCI in the clinic: evaluation of the sensitivity and specificity of a computerised test battery, the Hopkins Verbal Learning Test and the MMSE
    Celeste A de Jager
    Oxford Project to Investigate Memory and Ageing OPTIMA, Department of Physiology, Anatomy and Genetics, University of Oxford, UK
    Age Ageing 38:455-60. 2009
    ..We evaluated whether the computerised cognitive test battery, CogState, was as sensitive to MCI as two well-validated 'paper-and-pencil' tests, the Hopkins Verbal Learning Test (HVLT) and the Mini-Mental Status Examination (MMSE)...
  23. ncbi Mild cognitive impairment in the older population: Who is missed and does it matter?
    Blossom C M Stephan
    Department of Public Health and Primary Care, Institute of Public Health, Cambridge UK
    Int J Geriatr Psychiatry 23:863-71. 2008
    ..Of importance is the impact of missed diagnosis. The magnitude of missed 'at-risk' cases in the application of different MCI criteria in the population is unknown...
  24. ncbi A 24-week open-label extension study of memantine in moderate to severe Alzheimer disease
    Barry Reisberg
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Arch Neurol 63:49-54. 2006
    ..This study is an extension of a 28-week, randomized, double-blind, placebo-controlled study of memantine in 252 patients with moderate to severe Alzheimer disease...
  25. ncbi Performance of Brazilian long and short IQCODE on the screening of dementia in elderly people with low education
    Tíbor Rilho Perroco
    Old Age Research Group PROTER, Institute and Department of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Int Psychogeriatr 21:531-8. 2009
    ....
  26. ncbi Anticholinergic serum levels and cognitive performance
    O J Thienhaus
    Department of Psychiatry, University of Cincinnati, OH 45267-0559
    Eur Arch Psychiatry Clin Neurosci 240:28-33. 1990
    ..By contrast, patients with Alzheimer's disease are at risk of additional impairment. The introduction of anticholinergic serum activity as a monitoring technique for safe psychopharmacotherapy in geriatric patients is discussed...
  27. ncbi Prevalence of depression and its correlates in Hong Kong's Chinese older adults
    Iris Chi
    Sau Po Centre on Aging, The Univ of Hong Kong, Pokfulam Road, Hong Kong, USA
    Am J Geriatr Psychiatry 13:409-16. 2005
    ..The authors assessed the prevalence of depression among older adults and identified factors associated with it...
  28. ncbi Combining functional scales and cognitive tests in screening for mild cognitive impairment at a university-based memory clinic in Brazil
    Izabella Dutra de Abreu
    Laboratory of Neuroscience LIM 27, Department of Psychiatry, School of Medicine, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 30:346-9. 2008
    ..To determine the diagnostic accuracy of the Mini-Mental State Examination combined to the Informant Questionnaire on Cognitive Decline in the Elderly for the identification of mild cognitive impairment...
  29. pmc Covariance PET patterns in early Alzheimer's disease and subjects with cognitive impairment but no dementia: utility in group discrimination and correlations with functional performance
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuroimage 23:35-45. 2004
    ..Expression of covariance patterns correlates with cognitive and functional performance measures, holding promise for meaningful associations with underlying biopathological processes...
  30. ncbi A review of translations and adaptations of the Mini-Mental State Examination in languages other than English and Spanish
    Melinda R Steis
    School of Nursing, The Pennsylvania State University, University Park, PA 16802, USA
    Res Gerontol Nurs 2:214-24. 2009
    ..The search resulted in 20 articles reporting on 15 language versions of the MMSE...
  31. pmc Cholesterol and cognitive performance in normal controls and the influence of elective statin use after conversion to mild cognitive impairment: results in a clinical trial cohort
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, Ariz, USA
    Neurodegener Dis 7:183-6. 2010
    ....
  32. ncbi Mild cognitive impairment: cognitive screening or neuropsychological assessment?
    Breno Satler Diniz
    Psychogeriatric Clinic and Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, School of Medicine, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 30:316-21. 2008
    ..We further address the diagnostic properties of the Mini-Mental State Examination and the Cambridge Cognitive Examination for the identification of the different mild cognitive impairment subtypes in clinical practice...
  33. ncbi Five-year outcome of normal pressure hydrocephalus with or without a shunt: predictive value of the clinical signs, neuropsychological evaluation and infusion test
    S Savolainen
    Department of Neurosurgery, University Hospital, Kuopio, Finland
    Acta Neurochir (Wien) 144:515-23; discussion 523. 2002
    ....
  34. ncbi Memantine treatment in patients with mild to moderate Alzheimer's disease already receiving a cholinesterase inhibitor: a randomized, double-blind, placebo-controlled trial
    Anton P Porsteinsson
    Alzheimer s Disease Care, Research and Education Program, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14620, USA
    Curr Alzheimer Res 5:83-9. 2008
    ..To evaluate the efficacy and safety of memantine in patients with mild to moderate Alzheimer's disease (AD) receiving cholinesterase inhibitor (ChEI) treatment...
  35. ncbi Long-term effects of rivastigmine treatment on neuropsychiatric and behavioral disturbances in nursing home residents with moderate to severe Alzheimer's disease: results of a 52-week open-label study
    Peter M Aupperle
    Division of Geriatric Psychiatry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA
    Curr Med Res Opin 20:1605-12. 2004
    ..To evaluate the safety and efficacy of long-term treatment with rivastigmine (3-12 mg/day) and its effects on neuropsychiatric and behavioral disturbances in nursing home patients with moderate to severe probable Alzheimer's disease (AD)...
  36. ncbi The "time and change" test: an appropriate method to detect cognitive decline in the elderly
    Chiara Mussi
    Department of Geriatrics and Gerontology, University of Modena and Reggio Emilia, Italy
    J Geriatr Psychiatry Neurol 15:12-5. 2002
    ..We conclude that the T&C should be implemented in primary care because it quickly identifies elderly patients with cognitive impairment who need a more accurate evaluation...
  37. ncbi Validation of the Seven Minute Screen and Syndrom Kurztest among elderly Norwegian outpatients
    Arvid Skjerve
    Department of Clinical Psychology, University of Bergen, Bergen, Norway
    Int Psychogeriatr 20:807-14. 2008
    ....
  38. ncbi Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease
    Laura Mickes
    Department of Psychology, University of California, San Diego, CA 92093 0109, USA
    Neuropsychology 21:696-705. 2007
    ....
  39. ncbi Cognitive reserve and the relationship between depressive symptoms and awareness of deficits in dementia
    Mary Beth Spitznagel
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island, USA
    J Neuropsychiatry Clin Neurosci 18:186-90. 2006
    ..Findings suggest cognitive reserve moderates the depression/awareness relationship in dementia, which may explain previously discrepant findings...
  40. ncbi Social cognition in nursing home residents with and without cognitive impairment
    Allyson M Washburn
    Saybrook Graduate School and Research Center, San Francisco, CA 94111, USA
    J Gerontol B Psychol Sci Soc Sci 61:P174-9. 2006
    ..An improved understanding and assessment of the basic cognitive mechanisms underlying the ability of persons with dementia to interact with others would inform the design of interventions to optimize their social functioning...
  41. ncbi The temporal limits of cognitive change from music therapy in elderly persons with dementia or dementia-like cognitive impairment: a randomized controlled trial
    Robert A Bruer
    Mental Health Centre Penetranguishene, ON
    J Music Ther 44:308-28. 2007
    ..With many music therapists working in geriatric settings, more research is justified to both replicate this study and provide better guidance into the effective use of music therapy in the treatment of dementia...
  42. pmc The development of a semi-structured home interview (CHIF) to directly assess function in cognitively impaired elderly people in two cultures
    H C Hendrie
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int Psychogeriatr 18:653-66. 2006
    ..Assessing function is a crucial element in the diagnosis of dementia. This information is usually obtained from key informants. However, reliable informants are not always available...
  43. ncbi Nonpharmacological cognitive interventions in aging and dementia
    Amarilis Acevedo
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, and Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida 33140, USA
    J Geriatr Psychiatry Neurol 20:239-49. 2007
    ..It is concluded that cognitive interventions in the elderly show considerable promise and deserve further study...
  44. ncbi Screening for amnestic mild cognitive impairment and early Alzheimer's disease with M@T (Memory Alteration Test) in the primary care population
    L Rami
    Memory Alzheimer Unit, Department of Neurology, Institute of Neurosciences, Hospital Clinic i Universitari de Barcelona, Institut d Investigacio Biomedica August Pi i Sunyer, Spain
    Int J Geriatr Psychiatry 22:294-304. 2007
    ..To design and validate a new screening test for amnestic Mild Cognitive Impairment (A-MCI) and early stage Alzheimer's disease (AD)...
  45. ncbi The traveling salesman problem as a new screening test in early Alzheimer's disease: an exploratory study. Visual problem-solving in AD
    Luc Pieter De Vreese
    Special Dementia Care Unit, Nursing Home Facility IX Gennaio, Modena, Italy
    Aging Clin Exp Res 17:458-64. 2005
    ..Some preliminary information was collected on the diagnostic accuracy of the Traveling Salesman Problem (TSP) compared with the Mini-Mental State Examination (MMSE) in recognizing early AD from normal aging...
  46. pmc Executive dysfunctions across adulthood: measurement properties and correlates of the DEX self-report questionnaire
    Denis Gerstorf
    Department of Human Development and Family Studies, The Pennsylvania State University, State College, PA 16802, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 15:424-45. 2008
    ..We discuss implications for the validity of the instrument as well as directions for future research on executive functioning difficulties in everyday life...
  47. ncbi Differential item functioning related to education and age in the Italian version of the Mini-mental State Examination
    Paul K Crane
    Department of Internal Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Int Psychogeriatr 18:505-15. 2006
    ..We were also interested in exploring the significance of DIF in screening tests...
  48. ncbi Antibodies against GM1 in demented patients
    Eleni Hatzifilippou
    Neuroimmunological Laboratory of the 1st Department of Neurology Aristotelian University, AHEPA Hospital, Thessaloniki, Greece
    Am J Alzheimers Dis Other Demen 23:274-9. 2008
    ..The findings of this study are indicative of a possible correlation between the levels of anti-GM1 and the severity of dementia, mainly of the vascular type...
  49. ncbi Primary care screening for cognitive impairment in elderly veterans
    Kerry Donnelly
    Veterans Affairs Western New York Healthcare System, Bufallo, NY 14215, USA
    Am J Alzheimers Dis Other Demen 23:218-26. 2008
    ..There was no evidence to support the current interview-based screening procedure. Additional research with brief standardized screening is encouraged...
  50. ncbi Behavioral and psychological symptoms of dementia in relation to level of cognitive impairment
    Hugo Lövheim
    Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umea University, Umea, Sweden
    Int Psychogeriatr 20:777-89. 2008
    ..The aim of the present study was to describe the probability of the occurrence of these symptoms of dementia in relation to the level of cognitive impairment...
  51. ncbi Facial emotion recognition deficit in amnestic mild cognitive impairment and Alzheimer disease
    Ilaria Spoletini
    IRCCS Santa Lucia Foundation, Rome, Italy
    Am J Geriatr Psychiatry 16:389-98. 2008
    ..A secondary aim was to investigate relationships between facial emotion recognition and cognitive performances...
  52. ncbi Functional cognitive assessment scale (FUCAS): a new scale to assess executive cognitive function in daily life activities in patients with dementia and mild cognitive impairment
    Fotini Kounti
    School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Hum Psychopharmacol 21:305-11. 2006
    ..Functional Cognitive Assessment Scale (FUCAS) is a new reliable (alpha > 0.89 - 0.92) cognitive-behavioral scale that assesses executive function in daily life activities directly in patients with dementia...
  53. ncbi Association between apolipoprotein E4 and cognitive decline in elderly adults
    Chris J Packard
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    J Am Geriatr Soc 55:1777-85. 2007
    ..To determine the influence of apolipoprotein E on cognitive decline in a cohort of elderly men and women...
  54. ncbi Longitudinal trajectories of cognitive change in preclinical Alzheimer's disease: a growth mixture modeling analysis
    Brent J Small
    School of Aging Studies, University of South Florida, Tampa, FL 33620, USA
    Cortex 43:826-34. 2007
    ..Finally, persons who were misclassified as preclinical AD had fewer years of education and poorer MMSE scores at baseline...
  55. ncbi Factor structure of patient and caregiver ratings on the dementia quality of life instrument
    Rebecca E Ready
    Department of Psychology, The University of Massachusetts, Amherst, MA 01003, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 14:144-54. 2007
    ..Thus, data from patients demonstrated a factor structure that was highly consistent with caregiver report data and conformed to meaningful psychological constructs...
  56. ncbi Mini-Mental Status Examination: mixed Rasch model item analysis derived two different cognitive dimensions of the MMSE
    Kirsten Schultz-Larsen
    Center for Elder Research, Øster Søgade 18, 2, DK 1357 Copenhagen K, Denmark
    J Clin Epidemiol 60:268-79. 2007
    ..This study published in two companion papers assesses properties of the Mini-Mental State Examination (MMSE) with the purpose of improving the efficiencies of the methods of screening for cognitive impairment and dementia...
  57. ncbi Validation of the Telephone Interview for Cognitive Status (TICS) in Japanese
    Yoko Konagaya
    Obu Dementia Care Research and Training Center, Obu, Japan
    Int J Geriatr Psychiatry 22:695-700. 2007
    ..In recent years, the population of elderly people in Japan with dementia has increased. Detection of cognitive impairment in the early stages is important for adequate treatment, care, and prevention...
  58. ncbi Can clinical data predict progression to dementia in amnestic mild cognitive impairment?
    Lesley Fellows
    Dept of Neurology and Neurosurgery, Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada
    Can J Neurol Sci 35:314-22. 2008
    ..To determine whether clinical data obtained by history and physical examination can predict eventual progression to dementia in a cohort of elderly people with mild cognitive impairment...
  59. ncbi Seven minute screen performance in a normal elderly sample
    Arvid Skjerve
    Department of Clinical Psychology, University of Bergen, Bergen, Norway
    Int J Geriatr Psychiatry 22:764-9. 2007
    ..The objective of this study was to describe 7MS performance in a normal sample of people aged 65 years and older...
  60. ncbi ADCS Prevention Instrument Project: assessment of instrumental activities of daily living for community-dwelling elderly individuals in dementia prevention clinical trials
    Douglas Galasko
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Alzheimer Dis Assoc Disord 20:S152-69. 2006
    ..ADL change during a trial could trigger detailed evaluation or serve as an outcome measure. A brief, easily administered, and reliable ADL rating scale would assist prevention studies...
  61. ncbi [Dementia syndromes in the elderly: diagnostic procedures]
    Sylvie Pariel-Madjlessi
    Service de gériatrie et consultation mémoire, Hôpital Charles Foix et Faculté de médecine Pierre et Marie Curie Université Paris VI, Ivry sur Seine 94
    Presse Med 36:1442-52. 2007
    ..Lack of recognition of dementia in the elderly and delay in its diagnosis raise the question of screening to detect it at an earlier stage...
  62. ncbi Comparison of the Saint Louis University mental status examination and the mini-mental state examination for detecting dementia and mild neurocognitive disorder--a pilot study
    Syed H Tariq
    Division of Geriatric Medicine, St Louis University School of Medicine, St Louis, MO 63104, USA
    Am J Geriatr Psychiatry 14:900-10. 2006
    ..The Saint Louis University Mental Status (SLUMS) examination is a 30-point screening questionnaire that tests for orientation, memory, attention, and executive functions...
  63. ncbi [Screening of cognitive functions and the prediction of incident dementia by means of the SIDAM]
    Horst Bickel
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie der Technischen Universitat Munchen, Klinikum rechts der Isar, Germany
    Psychiatr Prax 34:139-44. 2007
    ..The suitability of the SIDAM (Structured Interview for the Diagnosis of Dementia) for the detection of pre-clinical stages of dementia...
  64. ncbi The Montreal Cognitive Assessment: validity and utility in a memory clinic setting
    Tasha Smith
    University of Southampton, England
    Can J Psychiatry 52:329-32. 2007
    ..To prospectively validate the Montreal Cognitive Assessment (MoCA) in a UK memory clinic...
  65. ncbi Alzheimer's disease and mild cognitive impairment: effects of shifting and interference in simple arithmetic
    Laura Zamarian
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    J Neurol Sci 263:79-88. 2007
    ..That means, they possibly process arithmetic not efficiently in daily-life situations...
  66. ncbi Comparison of the diagnostic accuracy of the Cognitive Performance Scale (Minimum Data Set) and the Mini-Mental State Exam for the detection of cognitive impairment in nursing home residents
    Louis Paquay
    Department of General Practice, KULeuven, Belgium
    Int J Geriatr Psychiatry 22:286-93. 2007
    ..The Cambridge Examination for Mental Disorders of the Elderly--Revised (CAMDEX-R) was used as the reference standard...
  67. ncbi Is functional decline necessary for a diagnosis of Alzheimer's disease?
    Kyung Won Park
    Department of Neurology, Alzheimer s Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX 77030, USA
    Dement Geriatr Cogn Disord 24:375-9. 2007
    ..The purpose of this study is to examine baseline differences and annualized cognitive and functional change scores in mild Alzheimer's disease (AD) patients with and without impaired activities of daily living (ADL)...
  68. ncbi Development of a short form of the Severe Impairment Battery
    Judith Saxton
    Univ of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 13:999-1005. 2005
    ..The authors sought to develop a short form of the Severe Impairment Battery (SIB)...
  69. ncbi Frontal lobe hypometabolism and impaired insight in Alzheimer disease
    Dylan G Harwood
    Neuropsychiatric Institute and Hospital, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Univ of California, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 13:934-41. 2005
    ..The authors examined the relationship between impaired insight regarding cognitive and functional deficits and frontal cortex hypometabolism in 41 patients with Alzheimer disease (AD)...
  70. ncbi Cerebral volume loss, cognitive deficit and neuropsychological performance: comparative measures of brain atrophy: I. Dementia
    Erin D Bigler
    Department of Psychiatry and Neuroscience, Brigham Young University, Provo, Utah 84602, USA
    J Int Neuropsychol Soc 10:442-52. 2004
    ....
  71. ncbi Executive dysfunction in Alzheimer disease
    Margaret M Swanberg
    Department of Neurology, David Geffen School of Medicine at UCLA, 90095 1769, USA
    Arch Neurol 61:556-60. 2004
    ..Executive dysfunction (EDF) is common in Alzheimer disease (AD); however, its relationship to other symptoms is difficult to assess in patients with AD...
  72. ncbi Prevalence of non-dementing cognitive disturbances and their association with vascular risk factors in an elderly population
    Massimiliano Prencipe
    J Neurol 250:907-12. 2003
    ..9 (95 % CI 1.8.-4.6) for untreated hypertensive patients. In conclusion, hypertension is significantly and independently associated with both CIND and CMI, and the risk of CIND is higher in untreated than treated hypertensive patients...
  73. ncbi Early detection of isolated memory deficits in the elderly: the need for more sensitive neuropsychological tests
    C A De Jager
    OPTIMA, Radcliffe Infirmary Trust, Oxford
    Psychol Med 32:483-91. 2002
    ..The aim of this study was to see whether sensitive neuropsychological tests could identify pre-clinical cognitive deficits and to characterize the cognitive profile of a subgroup with poor memory...
  74. ncbi Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI)
    Sue J Kang
    Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong Kangnam Ku, Seoul 135 710, South Korea
    J Geriatr Psychiatry Neurol 17:32-5. 2004
    ..6, P<.001). Total CGA-NPI scores also correlated highly with total NPI scores (r= 0.86, P<.001). These results suggest that the CGA-NPI can substitute for the NPI, saving administration time...
  75. ncbi Cognitively impaired older adults: risk profiles for institutionalization
    Laurel A Strain
    Centre on Aging, and Department of Sociology, University of Manitoba, Winnipeg, Canada
    Int Psychogeriatr 15:351-66. 2003
    ....
  76. ncbi Diagnosing cognitive impairment and dementia in primary health care -- a more active approach is needed
    Minna Lopponen
    Institute of Clinical Medicine, General Practice, University of Turku, Finland
    Age Ageing 32:606-12. 2003
    ..to determine the documentation rate of dementia in primary health care, the clinical characteristics of patients with documented and undocumented dementia, and the diagnostic evaluations made in cognitive impairment...
  77. ncbi Behavioral and endocrinological evaluation of music therapy for elderly patients with dementia
    Mizue Suzuki
    School of Nursing, Mie Prefectual College of Nursing, 1 1 1 Yumegaoka, Tsu, Mie 514 0116, Japan
    Nurs Health Sci 6:11-8. 2004
    ..These results suggest that the combination of endocrinological measurements, behavioral evaluations and functional assessment methods are useful in evaluating the effects of music therapy in persons with senile dementia...
  78. ncbi Assessing clinically relevant cognitive decline: preliminary data on a new method
    V Isella
    Neurology Section, San Gerardo Hospital, DNTB University of Milan Bicocca, Via Donizetti 106, I 20052 Monza, Italy
    Neurol Sci 24:236-41. 2003
    ....
  79. ncbi Everyday numerical abilities in Alzheimer's disease
    Laura Martini
    Universitätsklinik für Neurologie, Innsbruck, Austria
    J Int Neuropsychol Soc 9:871-8. 2003
    ..Assessment of everyday numerical skills may be crucial in planning adequate support for patients, for example in handling money, but also in designing targeted training programs...
  80. ncbi The clock drawing test as a valid screening method for mild cognitive impairment
    Sayaka Yamamoto
    Department of Geriatrics, Medicine in Growth and Aging, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Dement Geriatr Cogn Disord 18:172-9. 2004
    ..7%) and specificity (75.6%), than were the other protocols. The CDT, as a handy screening method, may be useful for clinicians to reliably identify subjects with MCI, and it may contribute to early detection of dementia...
  81. ncbi [Memory clinic in the day hospital]
    M Burge
    Zentrum Geriatrie Rehabilitation, Spital Bern Ziegler
    Praxis (Bern 1994) 92:1857-62. 2003
    ..Frequently asked questions, common problems and diagnostic difficulties will be elucidated, while focusing on diagnostic and therapeutic discussions and the contents of the consultations...
  82. ncbi Effects of galantamine on working memory and global functioning in patients with mild cognitive impairment: a double-blind placebo-controlled study
    Jennifer Koontz
    Southern California Institute for Research and Education, Graduate School of Education and Psychology, Pepperdine University, Irvine, California, USA
    Am J Alzheimers Dis Other Demen 20:295-302. 2005
    ..There were also improvements in the galantamine group on two of six measures in the Cambridge Automated Neuropsychiatric Test Assessment Battery and in immediate free recall on the California Verbal Learning Test...
  83. ncbi The influence of cognitive impairment and psychiatric symptoms on daily functioning in nursing facilities: a longitudinal study
    Susan K Schultz
    Department of Psychiatry, University of Iowa College of Medicine, 500 Newton Road, Iowa City, Iowa 52242 1000, USA
    Ann Clin Psychiatry 14:209-13. 2002
    ..These findings may have implications for treatment interventions that seek to enhance functioning in the skilled nursing setting...
  84. ncbi Predictors of preclinical Alzheimer disease and dementia: a clinicopathologic study
    James E Galvin
    Department of Neurology, Alzheimer s Disease Research Center, School of Medicine, Washington University, St Louis, MO 63108, USA
    Arch Neurol 62:758-65. 2005
    ..To understand the earliest signs of cognitive decline caused by Alzheimer disease (AD) and other illnesses causing dementia, information is needed from well-characterized individuals without dementia studied longitudinally until autopsy...
  85. ncbi Estrogen replacement therapy: effects on the cognitive functioning and clinical course of women with Alzheimer's disease
    Andrew J Levine
    Neuropsychiatric Institute, University of California, Los Angeles, 760 Westwood Plaza, Room C8 747 NPI, Los Angeles, CA 90024 1759, USA
    Arch Clin Neuropsychol 19:769-78. 2004
    ....
  86. ncbi [Age- and education-specific reference values for the cognitive test of the SIDAM (Structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia and dementias of other etiology according to ICD-10 and DSM-IV)]
    A Busse
    Klinik und Poliklinik fur Psychiatrie, Universitat Leipzig, Johannisallee 20, 04317 Leipzig, Germany
    Z Gerontol Geriatr 35:565-74. 2002
    ..This report presents age- and education-specific norms for the cognitive assessment of the SIDAM, obtained in a population-based sample of elderly people aged 75 and over (n=1001)...
  87. ncbi Objective assessment of the degree of dementia by means of EEG
    Martin Brunovsky
    3rd Faculty of Medicine, Charles University, Psychiatric Centre, Faculty Hospital Bulovka, Prague, Czech Republic
    Neuropsychobiology 48:19-26. 2003
    ..The results also suggest that the EEG coherences are of particular interest in dementia, being an indicator of the signal transfer between various parts of the brain cortex...
  88. ncbi Predictive accuracy of MCI subtypes for Alzheimer's disease and vascular dementia in subjects with mild cognitive impairment: a 2-year follow-up study
    S M C Rasquin
    Research Institute Brain and Behavior, Department of Psychiatry and Neuropsychology, University of Maastricht, University Hospital Maastricht, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 19:113-9. 2005
    ....
  89. ncbi Occurrence of cognitive impairment and dementia after the age of 60: a population-based study from Northern Italy
    Diana De Ronchi
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Dement Geriatr Cogn Disord 19:97-105. 2005
    ..To evaluate the age, gender and education distribution of both cognitive impairment and dementia in the whole old age range of the elderly (from 61 years of age and over)...
  90. ncbi Executive function impairment in community elderly subjects with questionable dementia
    Linda C W Lam
    Department of Psychiatry, Chinese University of Hong Kong, Shatin, Hong Kong SAR
    Dement Geriatr Cogn Disord 19:86-90. 2005
    ..The neurocognitive profile of community-dwelling Chinese subjects with 'questionable' dementia was studied...
  91. ncbi Semantic memory impairment in the earliest phases of Alzheimer's disease
    Asmus Vogel
    Memory Disorders Research Unit, Neuroscience Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Dement Geriatr Cogn Disord 19:75-81. 2005
    ..The results imply that assessment of semantic memory is relevant in the evaluation of patients with suspected AD...
  92. pmc Effect of vascular lesions on cognition in Alzheimer's disease: a community-based study
    Robert G Riekse
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 52:1442-8. 2004
    ....
  93. ncbi Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes
    Fulvia Castelli
    Institute of Cognitive Neuroscience, University College London, UK
    Brain 125:1839-49. 2002
    ..This finding suggests a physiological cause for the mentalizing dysfunction in autism: a bottleneck in the interaction between higher order and lower order perceptual processes...
  94. ncbi Comparison of verbal memory impairment rates in mild cognitive impairment
    Geoffrey Tremont
    Rhode Island Hospital Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Clin Exp Neuropsychol 32:630-6. 2010
    ..Future studies can address the longitudinal course of impairment on these measures...
  95. ncbi [The need of the elderly for nursing and social services in the community of Kaunas district]
    Lina Hitaite
    Garliava Hospital, the branch of Kaunas District Hospital, Garliava, Lithuania
    Medicina (Kaunas) 43:903-8. 2007
    ..The aim of this study was to evaluate the need of the elderly for outpatient nursing and social services in Kaunas district...
  96. pmc Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease
    Tracy R Melzer
    Van der Veer Institute for Parkinson s and Brain Research, Christchurch 8011, New Zealand
    Brain 134:845-55. 2011
    ....
  97. ncbi To err is human, to monitor divine: environmental adaptations reduce everyday errors but do not improve monitoring
    Brianne Magouirk Bettcher
    Department of Neurology, Memory and Aging Center, University of California San Francisco, 350 Parnassus Ave, San Francisco, CA 94143, USA
    J Clin Exp Neuropsychol 33:1049-58. 2011
    ..However, the neuropsychological processes associated with monitoring differed across conditions. The results have implications for a neuropsychological model of error monitoring in dementia...
  98. ncbi Unilateral extradural motor cortex stimulation is safe and improves Parkinson disease at 1 year
    Anna Rita Bentivoglio
    Neurology, Catholic University, and Department of Neuroscience, AFaR Fatebenefratelli Hospital, Rome, Italy
    Neurosurgery 71:815-25. 2012
    ..The primary motor cortex, which is part of the corticobasal ganglia loops, may be an alternative option for the surgical treatment of Parkinson disease...
  99. ncbi Quantitative analysis of transthyretin, tau and amyloid-beta in patients with dementia
    Sara Friederike Gloeckner
    Department of Neurology, Georg August University, Gottingen, Germany
    J Alzheimers Dis 14:17-25. 2008
    ..A significant negative correlation of TTR CSF levels and disease severity in AD was observed...
  100. pmc Long-term associations between cholinesterase inhibitors and memantine use and health outcomes among patients with Alzheimer's disease
    Carolyn W Zhu
    Department of Geriatrics and Palliative Medicine, Mount Sinai School of Medicine, New York, NY, USA Electronic address
    Alzheimers Dement 9:733-40. 2013
    ....
  101. ncbi Postoperative mental impairment in hip fracture patients. A randomized study of reorientation measures in 223 patients
    L Stromberg
    Department of Orthopaedics, Huddinge University Hospital, Karolinska Institute, Sweden
    Acta Orthop Scand 70:250-5. 1999
    ..The mean total continuous hospitalization (transfers between departments and hospitals included) in the reorientation group was 22 (95% CI: 17-43) days, the corresponding figures for the controls were 30 (14-29) days...

Research Grants72

  1. Dyspraxia and Autonomic Control in Very Early AD
    Donald Royall; Fiscal Year: 2004
    ..Some dementia treatments are known to reduce HRV, and possibly mortality as well. Alternatively, some psychotropics may increase arrhythmia-related mortality, possibly via a central mechanism. ..
  2. VAS-COG 2007
    Donald Royall; Fiscal Year: 2007
    ..Many vascular cognitive disorders are preventable and potentially reversible. VAS-COG will provide a forum in which information on these important conditions can be exchanged and disseminated. [unreadable] [unreadable] [unreadable]..
  3. Insular AD Pathology and Autonomic Function
    Donald Royall; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  4. Neurogenetics & Mild Cognitive Impairment
    Angela Jefferson; Fiscal Year: 2007
    ..Furthermore, findings from the proposed pilot study will generate feasibility data for developing a future, large-scale neurogenetics research study. [unreadable] [unreadable] [unreadable]..
  5. Sex Hormones, Related Polymorphisms & Cognitive Decline
    Kristine Yaffe; Fiscal Year: 2006
    ..Further knowledge of the association between sex hormones, hormone-related polymorphisms and cognitive decline may facilitate preventative strategies to maintain independence and to promote optimum brain aging. ..
  6. MCI & decisional capacity to provide informed consent
    Angela Jefferson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. Cardiovascular disease and neurocognition in the elderly
    Angela Jefferson; Fiscal Year: 2004
    ..abstract_text> ..
  8. Metabolic Syndrome and Cognitive Impairment
    Kristine Yaffe; Fiscal Year: 2005
    ..If elders with metabolic syndrome have increased risk of developing cognitive impairment, this would have important clinical and public health significance. ..
  9. ESTROGEN COMPOUNDS, COGNITION & DEMENTIA IN OLDER WOMEN
    Kristine Yaffe; Fiscal Year: 2002
    ..This award will foster the applicant's development towards becoming an independent investigator in aging research. ..
  10. AGE RELATED NEURODEGENERATIVE DISEASES IN MICRONESIA
    Douglas Galasko; Fiscal Year: 2006
    ..Subproject by Lee: 'PHF-tau in neurodegenerative diseases of Guam' will assess oxidative markers related to brain lesions in ALS, PDC and dementia. ..
  11. Biomarkers in Aging, MCI and Alzheimer's Disease
    Douglas Galasko; Fiscal Year: 2007
    ..Banked CSF and plasma will be available for further research into novel biomarkers, including broad-based proteomic studies. ..
  12. Culture Bias in Testing Expressive Ability In Dementia
    Ruth Tappen; Fiscal Year: 2003
    ..Both clinicians and researchers need to know which tests are appropriate, the extent to which the ethnicity of the examiner affects the results and how to interpret the scores obtained on both the newly developed and widely used tests. ..
  13. Improving informed consent in Alzheimer disease research
    Jason Karlawish; Fiscal Year: 2006
    ..The results will also begin to elucidate how experts make judgments of competency. [unreadable] [unreadable] [unreadable]..
  14. Multiple Factors Affecting Placebo Response in PD
    Christopher Goetz; Fiscal Year: 2004
    ..Defining these determinant influences will help enhance placebo responses in clinical practice and control them in clinical trials. ..
  15. Response of a Sample Population with the Deleterious HD allele RESPOND-HD
    Jane Paulsen; Fiscal Year: 2007
    ..This study will be among the first to compare ethical, legal and social experiences of having known genetic risk. ..
  16. TRAUMATIC BRAIN INJURY AND CELLULAR HOMEOSTASIS
    Stephen Scheff; Fiscal Year: 2003
    ..These studies will significantly enhance our understanding of the mechanisms following TBI and hopefully lead to therapies resulting in increased recovery. ..
  17. Light Treatment for Sleep/Wake Disturbances AD
    Jerome Yesavage; Fiscal Year: 2008
    ..Outcome will be documented by objective circadian activity rhythm parameters and standard sleep/wake measures both assessed by actigraphy. ..
  18. Consent Methods and Participation in Geriatric Clinical Research
    Jason Karlawish; Fiscal Year: 2009
    ..These results will assist researchers and proxies in conducting subject-centered informed consent discussions. ..
  19. Vascular Depression: Longitudinal Changes
    Warren D Taylor; Fiscal Year: 2010
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  20. SYNAPTIC CHANGE IN MILD COGNITIVE IMPAIRMENT
    Stephen W Scheff; Fiscal Year: 2010
    ..Successful completion of the proposed studies will lead to new insights into the mechanisms underlying MCI and early AD and contribute to the development of effective pharmacologic therapies for AD. ..
  21. Intelligent Systems for Detection of Aging Changes
    Jeffrey A Kaye; Fiscal Year: 2010
    ....
  22. TREATMENTS FOR INSOMNIA
    Jerome Yesavage; Fiscal Year: 2003
    ..This five-year application will ultimately include 90 treatment subjects aged >60 years (three groups of 30 each). ..
  23. Cognitive Pathways to Disability
    Michelle Carlson; Fiscal Year: 2006
    ..abstract_text> ..
  24. Geriatric Depression Outcomes: Prognostic Factors
    Warren Taylor; Fiscal Year: 2007
    ..Discussion: These findings will better describe the role of neural connectivity and striatofrontal dysfunction in geriatric depression. ..
  25. RESPONSE OF THE AGING NERVOUS SYSTEM TO TRAUMA
    Stephen Scheff; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  26. Alzheimer's Diagnosis by Real-Time Motion Corrected FMRI
    Clifford Jack; Fiscal Year: 2004
    ..Aim number 4: to assess motion corrected fMRI as a diagnostic test for early Alzheimer's disease. ..
  27. AGING AND DEMENTIA--LONGITUDINAL COURSE OF SUBGROUPS
    Barry Reisberg; Fiscal Year: 2002
    ..Collectively, these cohorts include over 1300 persons. The comprehensive evaluations include behavioral, mental status, neuropsychologic, neurologic, neuroimaging, electrophysiologic, and postmortem studies. ..
  28. COMMUNITY EQUIPOISE AND THE ETHICS OF CLINICAL RESEARCH
    Jason Karlawish; Fiscal Year: 2002
    ..Karlawish advanced training in bioethics scholarship. Other sponsors include experts in clinical trial design, Alzheimers Disease research and empirical research in research ethics. ..
  29. NEUROPSYCHOLOGY AND DEMENTIA
    Jane Paulsen; Fiscal Year: 2002
    ..This award will facilitate the candidate's research efforts towards understanding brain-behavior relations in dementia and using this knowledge to assist families and individuals in treatment planning for the future. ..
  30. WANDERING-- BACKROUND AND PROXIMAL FACTORS
    Donna Algase; Fiscal Year: 2003
    ..abstract_text> ..
  31. Adverse Outcomes of Dual Use of Health Systems Among Older Male Veterans
    FREDRIC WOLINSKY; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  32. IDENTIFICATION OF CLINICALLY RELEVANT CHANGES IN HRQOL
    FREDRIC WOLINSKY; Fiscal Year: 2002
    ..abstract_text> ..
  33. Continuity of Care and Health Outcomes: Does It Really Matter?
    FREDRIC WOLINSKY; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  34. PREDICTING DEPRESSION OUTCOMES IN MEDICALLY ILL ELDERS
    Harold Koenig; Fiscal Year: 2003
    ..It will also provide important information to both guide future clinical trials and identify barriers to effective treatment of depression in these patients. ..
  35. Health and Health Services Use in the HRS/AHEAD
    FREDRIC WOLINSKY; Fiscal Year: 2008
    ..Linear and non-linear regression and random effects models will also be used where appropriate. [unreadable] [unreadable]..
  36. Culture-Fair Screening and Diagnosis of Early Dementia
    Ellen Grober; Fiscal Year: 2006
    ..Specific Aim 3: To estimate the effect of knowing race and education on the diagnostic process. ..
  37. RELIGION, AGING, AND HEALTH
    Neal Krause; Fiscal Year: 2007
    ..Included among these procedures are individual growth curve models and latent variable structural equation models. [unreadable] [unreadable]..
  38. Cognitive Enhancers Explored with PET Imaging
    Susan Schultz; Fiscal Year: 2003
    ....
  39. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Lon Schneider; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  40. Metabolic Syndrome and Atherosclerosis in South Asians
    Alka Kanaya; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable]..
  41. Cognitive Sequelae of early and mid-life depression
    Hochang Lee; Fiscal Year: 2008
    ..This award will provide groundwork for his long term goal of becoming an expert in clinical epidemiology of late life mental disorders. ..
  42. Determinants of Venous Thromboembolism in Older People
    Robert J Glynn; Fiscal Year: 2010
    ..Results will help identify high-risk older people, and potentially modifiable behaviors that influence risk of ..
  43. Diabetes in Neuropsychiatric Disorders
    Brian Kirkpatrick; Fiscal Year: 2009
    ..These studies will assess whether schizophrenia is associated with impaired glucose tolerance, and whether this abnormality predicts the subsequent risk of impaired fasting glucose with olanzapine administration. ..
  44. FAMILY FUNCTION, STROKE RECOVRY, AND CAREGIVER OUTCOMES
    Patricia Clark; Fiscal Year: 2002
    ....
  45. Dementia of Parkinson Type: Clinicopathologic Phenotype
    James Galvin; Fiscal Year: 2004
    ..At the completion of the award period, candidate plans to develop an independent R01 project derived from the data generated by the experiments described in this proposal. ..
  46. DYNAMIC GROWTH & CHANGE IN ADULT INTELLECTUAL ABILITIES
    John McArdle; Fiscal Year: 2004
    ..abstract_text> ..
  47. For-Profit Ownership and End-of-Life Care
    Elizabeth Bradley; Fiscal Year: 2009
    ..Relevance in lay language: We will generate knowledge about the influence of for-profit hospice ownership on the experiences of patients with cancer and their families. ..
  48. COMMUNITY EPIDEMIOLOGIC STUDY OF CAREGIVING AND HEALTH
    Liesi Hebert; Fiscal Year: 2004
    ..Factors found to minimize negative health effects will provide potential interventions to minimize stress and maintain the health of older caregivers, and thereby minimize the social and economic impacts of caregiving. ..
  49. Startle reflex amplitude and cortisol in PTSD.
    Mark Miller; Fiscal Year: 2005
    ....
  50. Functional Skills Training For Late Life Schizophrenia
    Thomas Patterson; Fiscal Year: 2005
    ..Data will allow us to determine short-term effects of our intervention, effectiveness of maintenance sessions, and post-intervention duration of treatment effects. ..
  51. TRIAL TO REDUCE DELIRIUM IN AGED POST ACUTE PATIENTS
    Edward Marcantonio; Fiscal Year: 2004
    ..If the DAP is successful in reducing delirium and improving functional recovery, our findings will serve as a model of a targeted approach to improve the care of elders in the post-acute setting. ..
  52. OPTIMAL PREHOSPITAL CARE OF CHILDHOOD CARDIAC ARREST
    Ian Stiell; Fiscal Year: 2004
    ..The PIs propose to conduct a large feasibility review in five urban areas and to conduct four study planning workshops. ..
  53. LONG-TERM LORAZEPAM USE AND ACUTE TOXICITY IN THE AGED
    Nunzio Pomara; Fiscal Year: 2005
    ..index of brain white matter organization) contribute most strongly to the acute effects of lorazepam on cognitive/motor performance or postural sway in elderly individuals receiving long-term lorazepam treatment for GAD? ..
  54. PHARMACOKINETICS OF NICOTINE IN TWINS
    Gary Swan; Fiscal Year: 2002
    ..Ultimately, this knowledge may lead to more informed and more finely targeted treatment of individuals who are either susceptible to nicotine addiction or are already addicted to this substance. ..
  55. Cognitive Effects of Opioids in Older Adults
    Monique Cherrier; Fiscal Year: 2006
    ..abstract_text> ..
  56. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Anton Porsteinsson; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  57. Obesity, Oxidative Stress, and Diabetes in Older Adults
    Alka Kanaya; Fiscal Year: 2007
    ..If these markers are implicated in causing diabetes, then this would lead to testing whether vitamins or other supplements that target these markers may decrease the risk of diabetes in obese individuals. [unreadable] [unreadable]..
  58. Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older Women
    Richard Semba; Fiscal Year: 2008
    ..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
  59. VITAMIN A SUPPLEMENTATION FOR HIV INFECTED CHILDREN
    Richard Semba; Fiscal Year: 2002
    ....
  60. Second International Brainstorming Meeting on Parkinson Disease: Nosology
    Irene Litvan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  61. Siemens Symbia T SPECT-CT Scanner
    Andrew Newberg; Fiscal Year: 2006
    ..Overall, this scanner will become a major tool for our present and future research programs with a focus on brain SPECT imaging, but also the potential to include many other types of studies. [unreadable] [unreadable]..
  62. THE SLEEP HEART HEALTH STUDY
    Anne Newman; Fiscal Year: 2007
    ..Accomplishing these goals will provide important information concerning the public health impact of SDB. [unreadable] [unreadable]..
  63. Secular Changes in Alzheimer's Disease Risk
    Liesi Hebert; Fiscal Year: 2008
    ..This information is essential for planning the future health resources needed to care for people with AD. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) [unreadable] [unreadable] [unreadable] [unreadable]..
  64. Tailored Activity to Improve Affect in Dementia at Home
    Laura Gitlin; Fiscal Year: 2006
    ..This pilot study will provide critical data by which to refine and standardize the intervention manual and protocols, and structure the design of a large-scale randomized clinical trial. ..
  65. Family Centered Advance Care Planning
    Maureen Lyon; Fiscal Year: 2007
    ..abstract_text> ..
  66. RESEARCH PROGRAM TO PROMOTE OPTIMAL AGING IN PLACE
    Laura Gitlin; Fiscal Year: 2004
    ..It is anticipated that at the conclusion of the grant program the SHI will have an active research program that is multidisciplinary, nationally recognized, and addresses critical issues in independent living. ..
  67. Depression and Brain Metabolism
    Dan Iosifescu; Fiscal Year: 2007
    ..The development of a larger scale R01 project investigating the role of brain energy metabolism in a population of treatment-resistant subjects with MDD will be started during the last two years of the award period. ..
  68. Health and Perceived Cognition in Post-CABG Patients
    John Gunstad; Fiscal Year: 2004
    ..A better understanding of the factors contributing to subjective cognitive complaints may lead to improved patient care and reduced health care costs. ..
  69. Prevention of post-stroke depression-treatment strategy
    Robert Robinson; Fiscal Year: 2006
    ..unreadable] [unreadable]..