electroconvulsive therapy

Summary

Summary: Electrically induced convulsions primarily used in the treatment of severe affective disorders and schizophrenia.

Top Publications

  1. ncbi Electroconvulsive therapy in depressive illness that has not responded to drug treatment
    Syed S Husain
    Rowan House, Sandalwood Court, Highworth Road, Swindon, SN3 4WF, United Kingdom
    J Affect Disord 83:121-6. 2004
  2. pmc Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, Georgia 30329, USA
    Nat Neurosci 10:1116-24. 2007
  3. ncbi Diagnosis and definition of treatment-resistant depression
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:649-59. 2003
  4. ncbi Objective cognitive performance associated with electroconvulsive therapy for depression: a systematic review and meta-analysis
    Maria Semkovska
    Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, St Patrick s University Hospital, Ireland
    Biol Psychiatry 68:568-77. 2010
  5. pmc Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder
    Jennifer S Perrin
    Applied Health Sciences Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen AB25 2ZH, United Kingdom
    Proc Natl Acad Sci U S A 109:5464-8. 2012
  6. ncbi A randomized, controlled trial with 6-month follow-up of repetitive transcranial magnetic stimulation and electroconvulsive therapy for severe depression
    Savitha Eranti
    Section of Old Age Psychiatry, Department of Biostatistics and Computing, Center for the Economics of Mental Health, Institute of Psychiatry, King s College London, and Department of Psychiatry, Pembury Hospital, Invicta Community Care NHS Trust, Kent, UK
    Am J Psychiatry 164:73-81. 2007
  7. ncbi Increased neurogenesis in a model of electroconvulsive therapy
    T M Madsen
    Neuropsychiatry Laboratory, Department of Psychiatry, H S Rigshospitalet, TMM, TGB, Copenhagen, Denmark
    Biol Psychiatry 47:1043-9. 2000
  8. pmc Continuation electroconvulsive therapy vs pharmacotherapy for relapse prevention in major depression: a multisite study from the Consortium for Research in Electroconvulsive Therapy (CORE)
    Charles H Kellner
    Department of Psychiatry, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 183 South Orange Avenue, Newark, NJ 07103, USA
    Arch Gen Psychiatry 63:1337-44. 2006
  9. ncbi Increase in hippocampal volume after electroconvulsive therapy in patients with depression: a volumetric magnetic resonance imaging study
    Pia Nordanskog
    Department of Psychiatry, Linkoping University, Linkoping, Sweden
    J ECT 26:62-7. 2010
  10. ncbi Efficacy of ECT in depression: a meta-analytic review
    Daniel Pagnin
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology University of Pisa, Italy
    J ECT 20:13-20. 2004

Detail Information

Publications336 found, 100 shown here

  1. ncbi Electroconvulsive therapy in depressive illness that has not responded to drug treatment
    Syed S Husain
    Rowan House, Sandalwood Court, Highworth Road, Swindon, SN3 4WF, United Kingdom
    J Affect Disord 83:121-6. 2004
    Antidepressant medication resistance is the commonest indication for electroconvulsive therapy (ECT) in Scotland. Evidence from the USA suggests that clinical response is reduced for medication resistant patients...
  2. pmc Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, Georgia 30329, USA
    Nat Neurosci 10:1116-24. 2007
    ..Although many of these approaches are experimental, the rapidly developing understanding of emotional circuit regulation is likely to provide exciting and powerful future treatments for debilitating mood and anxiety disorders...
  3. ncbi Diagnosis and definition of treatment-resistant depression
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:649-59. 2003
    ..It is apparent that there may be varying degrees of treatment resistance. Some staging methods to assess levels of treatment resistance in depression are being developed, but need to be tested empirically...
  4. ncbi Objective cognitive performance associated with electroconvulsive therapy for depression: a systematic review and meta-analysis
    Maria Semkovska
    Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, St Patrick s University Hospital, Ireland
    Biol Psychiatry 68:568-77. 2010
    b>Electroconvulsive therapy (ECT) is the most acutely effective treatment for depression, but is limited by cognitive side effects. However, research on their persistence, severity, and pattern is inconsistent...
  5. pmc Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder
    Jennifer S Perrin
    Applied Health Sciences Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen AB25 2ZH, United Kingdom
    Proc Natl Acad Sci U S A 109:5464-8. 2012
    To date, electroconvulsive therapy (ECT) is the most potent treatment in severe depression. Although ECT has been successfully applied in clinical practice for over 70 years, the underlying mechanisms of action remain unclear...
  6. ncbi A randomized, controlled trial with 6-month follow-up of repetitive transcranial magnetic stimulation and electroconvulsive therapy for severe depression
    Savitha Eranti
    Section of Old Age Psychiatry, Department of Biostatistics and Computing, Center for the Economics of Mental Health, Institute of Psychiatry, King s College London, and Department of Psychiatry, Pembury Hospital, Invicta Community Care NHS Trust, Kent, UK
    Am J Psychiatry 164:73-81. 2007
    Repetitive transcranial magnetic stimulation (rTMS) has been reported to be as effective as electroconvulsive therapy (ECT) for major depression...
  7. ncbi Increased neurogenesis in a model of electroconvulsive therapy
    T M Madsen
    Neuropsychiatry Laboratory, Department of Psychiatry, H S Rigshospitalet, TMM, TGB, Copenhagen, Denmark
    Biol Psychiatry 47:1043-9. 2000
    b>Electroconvulsive therapy (ECT) is a widely used and efficient treatment modality in psychiatry, although the basis for its therapeutic effect is still unknown...
  8. pmc Continuation electroconvulsive therapy vs pharmacotherapy for relapse prevention in major depression: a multisite study from the Consortium for Research in Electroconvulsive Therapy (CORE)
    Charles H Kellner
    Department of Psychiatry, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 183 South Orange Avenue, Newark, NJ 07103, USA
    Arch Gen Psychiatry 63:1337-44. 2006
    Although electroconvulsive therapy (ECT) has been shown to be extremely effective for the acute treatment of major depression, it has never been systematically assessed as a strategy for relapse prevention.
  9. ncbi Increase in hippocampal volume after electroconvulsive therapy in patients with depression: a volumetric magnetic resonance imaging study
    Pia Nordanskog
    Department of Psychiatry, Linkoping University, Linkoping, Sweden
    J ECT 26:62-7. 2010
    ..The mechanisms of action of the most effective antidepressive treatment, electroconvulsive therapy (ECT), still remains elusive, but recent animal research has provided evidence for a cell proliferative ..
  10. ncbi Efficacy of ECT in depression: a meta-analytic review
    Daniel Pagnin
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology University of Pisa, Italy
    J ECT 20:13-20. 2004
    This study analyzed the efficacy of electroconvulsive therapy (ECT) in depression by means a meta-analytic review of randomized controlled trials that compared ECT with simulated ECT or placebo or antidepressant drugs and by a ..
  11. ncbi Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats
    A Sartorius
    Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany
    Pharmacopsychiatry 42:270-6. 2009
    ..An increasing number of studies uses serum BDNF levels as a potential indicator for central nervous system alterations...
  12. ncbi Effectiveness of electroconvulsive therapy in community settings
    Joan Prudic
    Department of Biological Psychiatry, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 126, New York, NY 10032, USA
    Biol Psychiatry 55:301-12. 2004
    Clinical trials indicate that electroconvulsive therapy (ECT) is the most effective treatment for major depression, but its effectiveness in community settings has not been examined.
  13. ncbi Effects of electroconvulsive therapy on brain functional activation and connectivity in depression
    Erik B Beall
    Cleveland Clinic, Cleveland, OH 44195, USA
    J ECT 28:234-41. 2012
    ..The present study investigated brain function before and after electroconvulsive therapy (ECT) in patients with major depressive disorder (MDD) and demonstrated the effect of treatment on ..
  14. pmc Regional electric field induced by electroconvulsive therapy in a realistic finite element head model: influence of white matter anisotropic conductivity
    Won Hee Lee
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Neuroimage 59:2110-23. 2012
    ..the first computational study investigating the electric field (E-field) strength generated by various electroconvulsive therapy (ECT) electrode configurations in specific brain regions of interest (ROIs) that have putative roles in ..
  15. ncbi Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy
    Angela Merkl
    Department of Psychiatry Charité Universitätsmedizin, Campus Benjamin Franklin, Berlin, Germany
    Biol Psychiatry 69:772-9. 2011
    Metabolic changes after electroconvulsive therapy (ECT) have been described in depressed patients, but results are heterogeneous...
  16. ncbi Cerebrovascular pulsation and width of subarachnoid space during electroconvulsive therapy
    Andrzej F Frydrychowski
    Department of Physiology, Medical University of Gdansk, Gdansk, Poland
    J ECT 25:99-105. 2009
    The mechanism of electroconvulsive therapy (ECT) has not been comprehensively explained. A new noninvasive method of monitoring intracranial homeostasis during and after ECT provides additional insight into the mechanism of ECT...
  17. ncbi Effect of electroconvulsive therapy on brain 5-HT(2) receptors in major depression
    Lakshmi N Yatham
    UBC Department of Psychiatry, The University of British Columbia, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC V6T2A1, Canada
    Br J Psychiatry 196:474-9. 2010
    ..5-HT(2)) receptors were considered potential targets for therapeutic efficacy of electroconvulsive therapy (ECT), but pre-clinical studies showed that electroconvulsive shock up-regulates 5-HT(2) receptors in ..
  18. ncbi The effectiveness of electroconvulsive therapy in treatment-resistant depression: a naturalistic study
    Najeeb Khalid
    North Glamorgan NHS Trust, Merthyr Tydfil, Cardiff, UK
    J ECT 24:141-5. 2008
    b>Electroconvulsive therapy (ECT) is a very effective treatment of major depressive disorder...
  19. ncbi A survey of the practice of electroconvulsive therapy in Asia
    Worrawat Chanpattana
    Department of Psychiatry, Samitivej Srinakarin Hospital, Bangkok, Thailand
    J ECT 26:5-10. 2010
    To describe a comprehensive survey of the practice of electroconvulsive therapy (ECT) in Asia.
  20. ncbi The definition and meaning of treatment-resistant depression
    H A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, NY 10032, USA
    J Clin Psychiatry 62:10-7. 2001
    ..The Antidepressant Treatment History Form is presented as one method to formalize the evaluation of treatment adequacy and treatment resistance...
  21. ncbi Convulsive therapy: a review of the first 55 years
    M Fink
    Departments of Psychiatry and Neurology, Long Island Jewish Hillside Medical Center, Glen Oaks, Long Island, NY 11004, USA
    J Affect Disord 63:1-15. 2001
    ..Experiments to sustain its benefits with medications and with continuation ECT are underway. Its mode of action remains a mystery and this puzzle is an unappreciated challenge. The full impact of this intervention is yet to be felt...
  22. ncbi Treatment-resistant depression
    Alison Little
    Department of Family Medicine, Oregon Health and Science University, Portland, Oregon 97201, USA
    Am Fam Physician 80:167-72. 2009
    ..No treatment strategy appears to be better than another. Electroconvulsive therapy is effective as short-term therapy of treatment-resistant depression...
  23. ncbi Limbic-frontal circuitry in major depression: a path modeling metanalysis
    D A Seminowicz
    Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
    Neuroimage 22:409-18. 2004
    ....
  24. ncbi Randomized controlled trial of the cognitive side-effects of magnetic seizure therapy (MST) and electroconvulsive shock (ECS)
    Tammy D Moscrip
    Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY, USA
    Int J Neuropsychopharmacol 9:1-11. 2006
    ..seizure therapy (MST) is under development as a means of improving the cognitive side-effect profile of electroconvulsive therapy (ECT) by inducing more spatially delimited seizures that spare cortical regions involved in memory...
  25. ncbi A randomized controlled comparison of electroconvulsive therapy and repetitive transcranial magnetic stimulation in severe and resistant nonpsychotic major depression
    Leon Grunhaus
    Psychiatry Division and the Transcranial Magnetic Stimulation Laboratory at Sheba Medical Center, Tel Hashomer, Israel
    Biol Psychiatry 53:324-31. 2003
    ..In a previous report, we compared electroconvulsive therapy (ECT) and repetitive TMS (rTMS) and found ECT to be superior for psychotic major depression (MD); ..
  26. ncbi Continuation pharmacotherapy in the prevention of relapse following electroconvulsive therapy: a randomized controlled trial
    H A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, 1051 Riverside Dr, New York, NY 10032, USA
    JAMA 285:1299-307. 2001
    b>Electroconvulsive therapy (ECT) is highly effective for treatment of major depression, but naturalistic studies show a high rate of relapse after discontinuation of ECT.
  27. pmc Electroconvulsive therapy stimulus parameters: rethinking dosage
    ANGEL V PETERCHEV
    Division of Brain Stimulation and Therapeutic Modulation, Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York, NY, USA
    J ECT 26:159-74. 2010
    In this article, we review the parameters that define the electroconvulsive therapy (ECT) electrical stimulus and discuss their biophysical roles...
  28. ncbi World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders in Primary Care
    Michael Bauer
    University Hospital Carl Gustav Carus, Department of Psychiatry and Psychotherapy, Technische Universitat Dresden, Dresden, Germany
    World J Biol Psychiatry 8:67-104. 2007
    ..They deal primarily with biological treatment (including antidepressants, other psychopharmacological and hormonal medications, electroconvulsive therapy, light therapy).
  29. pmc Quick recovery of orientation after magnetic seizure therapy for major depressive disorder
    George Kirov
    Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, UK
    Br J Psychiatry 193:152-5. 2008
    ..Its use may be justified if it produces the antidepressant effects of electroconvulsive therapy (ECT), coupled with limited cognitive side-effects.
  30. ncbi Increased cortical GABA concentrations in depressed patients receiving ECT
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 160:577-9. 2003
    ..The purpose of this study was to determine if cortical GABA concentrations increase following a course of ECT...
  31. ncbi Absence of histological lesions in primate models of ECT and magnetic seizure therapy
    Andrew J Dwork
    Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA
    Am J Psychiatry 161:576-8. 2004
    ..The authors present preliminary findings from the first nonhuman primate neuropathological study of ECT to use perfusion fixation and adequate controls and the first to compare ECT with magnetic seizure therapy, to their knowledge...
  32. ncbi A meta-analysis of electroconvulsive therapy efficacy in depression
    King Han Kho
    GGZ Delfland, Locatie St Jorisweg, 2 Delft, The Netherlands
    J ECT 19:139-47. 2003
    Recently published controlled studies comparing electroconvulsive therapy (ECT) with other treatments for depression offer the opportunity to perform a meta-analysis of ECT in depression...
  33. ncbi Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression
    Sarah Biedermann
    Central Institute of Mental Health, Department of Neuroimaging, University of Heidelberg, Mannheim, Germany
    World J Biol Psychiatry 13:447-57. 2012
    ..acid (GABA) are associated with the pathomechanism of depression and treatment effects of electroconvulsive therapy (ECT). Thus, proton magnetic resonance spectroscopy (¹H MRS) at a 9...
  34. ncbi Changes in brain metabolism after ECT-positron emission tomography in the assessment of changes in glucose metabolism subsequent to electroconvulsive therapy--lessons, limitations and future applications
    E Z Schmidt
    Department of Psychiatry, Medical University Graz, Auenbruggerplatz 31, 8036 Graz, Austria
    J Affect Disord 106:203-8. 2008
    b>Electroconvulsive therapy (ECT) has been used as an effective treatment option in severe and treatment resistant cases of depression for decades. However the mode of action of ECT is still not fully understood...
  35. ncbi Efficacy and safety of electroconvulsive therapy in the treatment of bipolar disorder: a systematic review
    Marcio Versiani
    Institute of Psychiatry, Federal University of Rio de Janeiro IPUB UFRJ, Brazil
    J ECT 27:153-64. 2011
    To evaluate the efficacy and safety of electroconvulsive therapy (ECT) in bipolar disorder (BPD).
  36. ncbi Nigerian medical students attitudes to unmodified electroconvulsive therapy
    Bawo Onesirosan James
    Department of Clinical Services, Psychiatric Hospital, Uselu, Benin City, Nigeria
    J ECT 25:186-9. 2009
    b>Electroconvulsive therapy (ECT) is an effective and affordable form of treatment for a range of psychiatric disorders. Historical antecedents, the media, and movies have generated myths about its continued use and relevance.
  37. ncbi Propofol reduces cognitive impairment after electroconvulsive therapy
    Noam N Butterfield
    Department of Pharmacology and Therapeutics, Centre for Anesthesia and Analgesia, The University of British Columbia, Vancouver, Canada
    J ECT 20:3-9. 2004
    Cognitive impairments are the main complication after electroconvulsive therapy (ECT). Modification of treatment parameters has been shown to affect the magnitude of these impairments, but the role of anesthetic type remains unclear...
  38. pmc Patients' perspectives on electroconvulsive therapy: systematic review
    Diana Rose
    Service User Research Enterprise, PO34, Institute of Psychiatry, De Crespigny Park, London SE5 8AF
    BMJ 326:1363. 2003
    To ascertain patients' views on the benefits of and possible memory loss from electroconvulsive therapy.
  39. ncbi Predictors for the efficacy of electroconvulsive therapy: chart review of a naturalistic study
    King Han Kho
    GGZ Delfland, Delft, The Netherlands
    J Clin Psychiatry 66:894-9. 2005
    ..Several variables have been suggested that can predict the efficacy of electro-convulsive therapy (ECT) in patients suffering from depression. The results of studies into these predictors for ECT efficacy are not consistent...
  40. ncbi Use of continuation or maintenance electroconvulsive therapy in adolescents with severe treatment-resistant depression
    Neera Ghaziuddin
    Department of Psychiatry, University of Michigan, Ann Arbor, MI
    J ECT 27:168-74. 2011
    ..Subjects were treated with one or more index courses of electroconvulsive therapy (ECT) followed by continuation ECT (C-ECT, up to 6 months of ECT) or maintenance ECT (M-ECT; ECT beyond ..
  41. ncbi Patient satisfaction after electroconvulsive therapy
    Pascal Sienaert
    ECT Department, University Center Sint Jozef, Katholieke Universiteit Leuven, Leuvensesteenweg Kortenberg, Belgium
    J ECT 21:227-31. 2005
    We sought to determine the degree of satisfaction with bifrontal and right unilateral electroconvulsive therapy (ECT) and to investigate the relation with treatment-related variables, such as memory complaints, and patient-related ..
  42. ncbi Retrograde amnesia after electroconvulsive therapy: a temporary effect?
    Martijn Meeter
    Department of Cognitive Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    J Affect Disord 132:216-22. 2011
    Although electroconvulsive therapy (ECT) is generally considered effective against depression, it remains controversial because of its association with retrograde memory loss...
  43. ncbi Efficacy of electroconvulsive therapy is associated with changing blood levels of homovanillic acid and brain-derived neurotrophic factor (BDNF) in refractory depressed patients: a pilot study
    Tatsuya Okamoto
    Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1185-90. 2008
    b>Electroconvulsive therapy (ECT) is effective for patients with antidepressant medication-resistant depression. However, the mechanisms of ECT's effectiveness for treating depression are not fully understood...
  44. ncbi Cost-effectiveness of transcranial magnetic stimulation vs. electroconvulsive therapy for severe depression: a multi-centre randomised controlled trial
    Martin Knapp
    Centre for the Economics of Mental Health, King s College London, Institute of Psychiatry, UK
    J Affect Disord 109:273-85. 2008
    b>Electroconvulsive therapy (ECT) has a long history of use in treating depression. Repetitive transcranial magnetic stimulation (rTMS) has been introduced more recently to the treatment spectrum...
  45. pmc Unmodified electroconvulsive therapy: changes in knowledge and attitudes of Nigerian medical students
    Bawo O James
    Department of Clinical Services, Federal Psychiatric Hospital, Benin City, Nigeria
    Afr Health Sci 9:279-83. 2009
    ..In some developing countries, the process of change towards the full implementation and use of modified ECT has been slow. The unmodified format is still used for largely economic reasons despite the ethical concerns it raises...
  46. ncbi Anesthetic considerations for magnetic seizure therapy: a novel therapy for severe depression
    Paul F White
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9068, USA
    Anesth Analg 103:76-80, table of contents. 2006
    b>Electroconvulsive therapy (ECT) is a highly effective treatment for severe depression. However, its use is associated with significant posttreatment cognitive impairment...
  47. pmc Awareness and perceptions of electroconvulsive therapy among psychiatric patients: a cross-sectional survey from teaching hospitals in Karachi, Pakistan
    Mehreen Arshad
    Aga Khan University, Karachi, Pakistan
    BMC Psychiatry 7:27. 2007
    b>Electroconvulsive therapy (ECT) is shown to be effective in many psychiatric illnesses, but its distorted projection by the Pakistani media and its unregulated use by many physicians across the country have adversely affected its ..
  48. ncbi Personality disorder and the outcome of depression: meta-analysis of published studies
    Giles Newton-Howes
    Department of Psychological Medicine, Division of Neuroscience and Mental Health, Imperial College London, St Dunstan s Road, London W6 8RP, UK
    Br J Psychiatry 188:13-20. 2006
    ..There is conflicting evidence about the influence of personality disorder on outcome in depressive disorders...
  49. ncbi A review of the cognitive effects of electroconvulsive therapy in older adults
    Betina K Gardner
    Aged Mental Health Research Unit, Department of Psychological Medicine, Monash University, Victoria, Australia
    J ECT 24:68-80. 2008
    To review studies that examined the impact of electroconvulsive therapy (ECT) on cognitive functioning in depressed older people.
  50. ncbi Effect of electroconvulsive therapy in repetitive transcranial magnetic stimulation non-responder MDD patients: a preliminary study
    P N Dannon
    ECT TMS Unit, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Int J Neuropsychopharmacol 4:265-8. 2001
    ..Whether this is a result of reduced responsiveness to ECT in rTMS-resistant patients or a consequence of small sample size requires further study...
  51. ncbi Introduction of vagus nerve stimulation into a maintenance electroconvulsive therapy regimen: a case study and cost analysis
    Ronald L Warnell
    Department of Psychiatry, Loma Linda University, Loma Linda, CA 92354, USA
    J ECT 23:114-9. 2007
    ....
  52. ncbi Neurophysiological characterization of high-dose magnetic seizure therapy: comparisons with electroconvulsive shock and cognitive outcomes
    Yael M Cycowicz
    Division of Brain Stimulation and Therapeutic Modulation, Department of Psychiatry, New York State Psychiatric Institute, Columbia University Medical Center, New York, NY 10032, USA
    J ECT 25:157-64. 2009
    ..through achieving better control over therapeutic seizure induction than is possible with conventional electroconvulsive therapy. In this investigation, we present the first neurophysiological characterization of high-dose MST (HD-..
  53. ncbi Effect of electroconvulsive therapy on 5-HT1A receptor binding in patients with depression: a PET study with [11C]WAY 100635
    Tomoyuki Saijo
    Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan
    Int J Neuropsychopharmacol 13:785-91. 2010
    ..Although the present finding does not exclude the involvement of brain 5-HT1A systems in the antidepressant action of ECT, it may indicate the involvement of other neurotransmission mechanisms...
  54. ncbi Stimulus titration and ECT dosing
    Richard Abrams
    Department of Psychiatry, Chicago Medical School, North Chicago, Illinois 60064, USA
    J ECT 18:3-9; discussion 14-5. 2002
    The seizure threshold to electroconvulsive therapy (ECT) is defined entirely by the duration of the induced seizure, is multidetermined, and varies enormously with a wide variety of patient and treatment factors, including especially the ..
  55. ncbi Delirious mania and malignant catatonia: a report of 3 cases and review
    Mark B Detweiler
    Psychiatry Service, Veterans Affairs Medical Center, 1970 Roanoke Boulevard, Salem, VA 24153, USA
    Psychiatr Q 80:23-40. 2009
    ..Three case reports are presented to illustrate the diagnostic conundrum of delirious mania and several different presentations of malignant catatonia...
  56. ncbi Physical treatments for bipolar disorder: a review of electroconvulsive therapy, stereotactic surgery and other brain stimulation techniques
    Colleen Loo
    School of Psychiatry, University of New South Wales, Sydney, Australia
    J Affect Disord 132:1-13. 2011
    Despite pharmacological advances, bipolar disorder continues to be difficult to treat. This article reviews the evidence base for the use of electroconvulsive therapy (ECT) and other brain stimulation therapies in bipolar disorder.
  57. ncbi Successful use of donepezil in treatment of cognitive impairment caused by maintenance electroconvulsive therapy: a case report
    Naren P Rao
    Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
    J ECT 25:216-8. 2009
    Cognitive deficits are commonly associated with maintenance electroconvulsive therapy (ECT). Treatment of these cognitive deficits is important but difficult...
  58. ncbi Beat-to-beat hemodynamic monitoring during electroconvulsive therapy
    Pieter G K B Geersing
    Department of Anesthesiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J ECT 27:189-91. 2011
    Rapid parasympathetic and sympathetic hemodynamic effects during electroconvulsive therapy (ECT) may pose vulnerable patients to significant risk for cardiovascular complications...
  59. ncbi Delirious mania: clinical features and treatment response
    Rakesh Karmacharya
    Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA 02478, USA
    J Affect Disord 109:312-6. 2008
    ..To examine clinical characteristics and treatment responses of patients presenting with delirium and mania to a psychiatric inpatient unit...
  60. ncbi Medically and psychiatrically ill: the challenge of delirious mania
    Rohn S Friedman
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    Harv Rev Psychiatry 11:91-8. 2003
  61. ncbi ECT in the Asia Pacific region: what do we know?
    John D Little
    Grampians Psychiatric Services, Victoria, Australia
    J ECT 19:93-7. 2003
    ..To review and describe the practice of ECT in the Asia Pacific region in the year 2000...
  62. ncbi Electroconvulsive therapy in drug-induced psychiatric states and neuroleptic malignant syndrome
    Feriha Ozer
    Department of Neurology, Bakirkoy Neurology Center, Istanbul, Turkey
    J ECT 21:125-7. 2005
    ..Because the patient did not respond to other treatment modalities, electroconvulsive therapy (ECT) was applied, and a rapid improvement was observed both in the patient's NMS and also in Parkinson'..
  63. ncbi Does the experience of electroconvulsive therapy improve awareness and perceptions of treatment among relatives of patients?
    Sandeep K Grover
    Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J ECT 27:67-72. 2011
    Evidence suggests that the actual experience of electroconvulsive therapy (ECT) has a positive impact on perceptions regarding the treatment among patients and their relatives...
  64. ncbi Double-blind randomized controlled study comparing short-term efficacy of bifrontal and bitemporal electroconvulsive therapy in acute mania
    Raja M Hiremani
    Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
    Bipolar Disord 10:701-7. 2008
    Bifrontal electrode placement is as efficacious as bitemporal placement during electroconvulsive therapy (ECT) in depression but is associated with fewer cognitive adverse effects...
  65. ncbi Increased plasma concentration of brain-derived neurotrophic factor with electroconvulsive therapy: a pilot study in patients with major depression
    Christopher M Marano
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA
    J Clin Psychiatry 68:512-7. 2007
    The therapeutic mechanism of electroconvulsive therapy (ECT) is unknown. Animal research supports a neurotrophic effect of ECT...
  66. ncbi Electroconvulsive therapy for depression
    Sarah H Lisanby
    Division of Brain Stimulation and Therapeutic Modulation, New York State Psychiatric Institute, Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Dr, Unit 21, New York, NY 10032, USA
    N Engl J Med 357:1939-45. 2007
  67. ncbi Anesthesia for electroconvulsive therapy
    Zhengnian Ding
    Department of Anesthesiology and Pain Management, First Affiliated Hospital of Nanjing Medical University, China
    Anesth Analg 94:1351-64. 2002
  68. ncbi Effects of electroconvulsive therapy on frontal white matter in late-life depression: a diffusion tensor imaging study
    K Nobuhara
    Department of Neuropsychiatry, Kansai Medical University, Moriguchi City, Japan
    Neuropsychobiology 50:48-53. 2004
    This study was conducted to elucidate the effects of electroconvulsive therapy (ECT) on frontal white matter in late-life depressed patients...
  69. ncbi Raised plasma levels of tumor necrosis factor alpha in patients with depression: normalization during electroconvulsive therapy
    Knut A Hestad
    NTNU Norwegian University of Science and Technology, Department of Psychology, N 7440 Trondheim, Norway
    J ECT 19:183-8. 2003
    To examine whether electroconvulsive therapy (ECT) could modulate tumor necrosis factor (TNF)alpha levels in patients with depressive disorders.
  70. ncbi Comparison of repetitive transcranial magnetic stimulation and electroconvulsive therapy in unipolar non-psychotic refractory depression: a randomized, single-blind study
    Moacyr Alexandro Rosa
    Institute of Psychiatry, University of Sao Paulo, Sao Paulo SP, Brazil
    Int J Neuropsychopharmacol 9:667-76. 2006
    ..rTMS) can induce significant antidepressant effects and, for some patients, might be an alternative to electroconvulsive therapy (ECT)...
  71. ncbi Effect of concomitant pharmacotherapy on electroconvulsive therapy outcomes: short-term efficacy and adverse effects
    Harold A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York, New York, USA
    Arch Gen Psychiatry 66:729-37. 2009
    Medication resistance is the leading indication for use of electroconvulsive therapy (ECT) in major depression...
  72. ncbi Survey of the practice of electroconvulsive therapy in teaching hospitals in India
    Worrawat Chanpattana
    Department of Psychiatry, Bangkok Hospital, Bangkok, Thailand
    J ECT 21:100-4. 2005
    We sought to obtain an overview of electroconvulsive therapy (ECT) practice in teaching hospitals in India.
  73. ncbi Plasma concentrations of neuroactive steroids before and after electroconvulsive therapy in major depression
    Thomas C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Neuropsychopharmacology 30:1181-6. 2005
    ..in 31 pharmacotherapy-resistant depressed in-patients before and after unilateral electroconvulsive therapy (ECT) as a monotherapy over 4 weeks...
  74. ncbi Speed of response and remission in major depressive disorder with acute electroconvulsive therapy (ECT): a Consortium for Research in ECT (CORE) report
    Mustafa M Husain
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Clin Psychiatry 65:485-91. 2004
    ..b>Electroconvulsive therapy (ECT) is another treatment option...
  75. ncbi Vagus nerve stimulation (VNS) for treatment-resistant depression: efficacy, side effects, and predictors of outcome
    H A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Neuropsychopharmacology 25:713-28. 2001
    ..Evidence concerning VNS' long-term therapeutic benefits and tolerability will be critical in determining its role in treatment-resistant depression...
  76. ncbi A prospective, randomized, double-blind comparison of bilateral and right unilateral electroconvulsive therapy at different stimulus intensities
    H A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, NY 10032, USA
    Arch Gen Psychiatry 57:425-34. 2000
    Controversy persists about the use of right unilateral (RUL) and bilateral (BL) electroconvulsive therapy (ECT)...
  77. ncbi World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 1: Acute and continuation treatment of major depressive disorder
    Michael Bauer
    Neuropsychiatric Institute and Hospital, Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles ULCA, 300 UCLA Medical Plaza, Suite 2330, Los Angeles, CA 90095, USA
    World J Biol Psychiatry 3:5-43. 2002
    ..biological treatment (including antidepressants, other psychopharmacological and hormonal medications, electroconvulsive therapy, light therapy, adjunctive and novel therapeutic strategies) of young adults and also, albeit to a ..
  78. ncbi Morbidity and mortality in the use of electroconvulsive therapy
    Gregory A Nuttall
    Department of Anesthesiology, Mayo Clinic College of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J ECT 20:237-41. 2004
    There are a few large studies of the morbidity and mortality of electroconvulsive therapy (ECT)...
  79. ncbi Challenges in the treatment of depression with psychotic features
    Anthony J Rothschild
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Biol Psychiatry 53:680-90. 2003
    ..treatments for MDpsy include the combination of an antidepressant and an antipsychotic, amoxapine, or electroconvulsive therapy. Atypical antipsychotic medications may have particular relevance for the treatment of MDpsy because of ..
  80. ncbi Serum brain-derived neurotrophic factor (BDNF) is not associated with response to electroconvulsive therapy (ECT): a pilot study in drug resistant depressed patients
    Brisa Fernandes
    Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    Neurosci Lett 453:195-8. 2009
    ..b>Electroconvulsive therapy (ECT) is the most effective treatment method in refractory depression, although its mechanism of action ..
  81. ncbi Plasma Brain-Derived Neurotrophic Factor in treatment-resistant depressed patients receiving electroconvulsive therapy
    Armando Piccinni
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, Pisa, Italy
    Eur Neuropsychopharmacol 19:349-55. 2009
    ..These findings would suggest the potential usefulness of baseline plasma BDNF levels as predictors of response to ECT in treatment-resistant depressed patients...
  82. ncbi Butyrylcholinesterase gene mutations in patients with prolonged apnea after succinylcholine for electroconvulsive therapy
    H M Mollerup
    Danish Cholinesterase Research Unit, Department of Anaesthesiology, Copenhagen University Hospital, Herlev Hospital, Herlev, Denmark
    Acta Anaesthesiol Scand 55:82-6. 2011
    patients undergoing electroconvulsive therapy (ECT) often receive succinylcholine as part of the anesthetic procedure...
  83. ncbi Effectiveness of treatments for depression in older people
    Cathy J Frazer
    Centre for Mental Health Research, Australian National University, Canberra, ACT 0200, Australia
    Med J Aust 182:627-32. 2005
    ..To conduct a systematic review of the evidence for the effectiveness of a range of possible treatments for depression in older people...
  84. ncbi Antidepressant effects, of magnetic seizure therapy and electroconvulsive therapy, in treatment-resistant depression
    Sarah Kayser
    Department of Psychiatry and Psychotherapy, Sigmund Freud Strasse 25, University Hospital, Bonn, Germany
    J Psychiatr Res 45:569-76. 2011
    ..b>Electroconvulsive therapy (ECT) is highly efficacious in treatment-resistant depressive disorders, but cognitive side effects are ..
  85. ncbi Electroconvulsive Therapy (ECT) increases serum Brain Derived Neurotrophic Factor (BDNF) in drug resistant depressed patients
    Luisella Bocchio-Chiavetto
    Genetics Unit, IRCCS Centro S Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25123 Brescia, Italy
    Eur Neuropsychopharmacol 16:620-4. 2006
    ..Although future researches are needed, the results herein presented show for the first time that ECT is associated with changes in serum BDNF and further support the possible involvement of BDNF in antidepressant therapies...
  86. ncbi Using the Cambridge Neuropsychological Test Automated Battery (CANTAB) to assess the cognitive impact of electroconvulsive therapy on visual and visuospatial memory
    D W Falconer
    Department of Mental Health, Clinical Research Centre, Royal Cornhill Hospital, University of Aberdeen, Aberdeen AB25 2ZH, UK
    Psychol Med 40:1017-25. 2010
    The cognitive impact of electroconvulsive therapy (ECT) is rarely measured systematically in everyday clinical practice even though patient and clinician acceptance is limited by its adverse affect on memory...
  87. ncbi Effect of electroconvulsive therapy on biopterin and large neutral amino acids in severe, medication-resistant depression
    R Hoekstra
    Department of Psychiatry, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    Psychiatry Res 103:115-23. 2001
    ..and valine were measured in plasma of 20 severely depressed inpatients before and after a course of electroconvulsive therapy (ECT)...
  88. ncbi Electroconvulsive therapy in children and adolescents
    Hazem Shoirah
    Abbaseyya Hospital for Mental Health, Cairo, Egypt
    Expert Rev Neurother 11:127-37. 2011
    b>Electroconvulsive therapy (ECT) is a recognized and effective treatment in adults for several psychiatric and neurological conditions in which the use of pharmacotherapy is ineffective, untimely or contraindicated...
  89. ncbi Electroconvulsive therapy decreases dopamine D₂receptor binding in the anterior cingulate in patients with depression: a controlled study using positron emission tomography with radioligand [¹¹C]FLB 457
    Tomoyuki Saijo
    Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan
    J Clin Psychiatry 71:793-9. 2010
    b>Electroconvulsive therapy (ECT) has been confirmed as one of the most effective treatments in drug-resistant major depression. However, the mechanism of ECT is still poorly understood...
  90. ncbi A computational model of direct brain excitation induced by electroconvulsive therapy: comparison among three conventional electrode placements
    Siwei Bai
    Graduate School of Biomedical Engineering, Faculty of Engineering, University of New South Wales, Sydney, Australia
    Brain Stimul 5:408-21. 2012
    b>Electroconvulsive therapy (ECT) is a highly effective treatment for severe depressive disorder...
  91. ncbi Efficacy and safety of continuation and maintenance electroconvulsive therapy in depressed elderly patients: a systematic review
    Audrey M van Schaik
    GGZ ingeest VU University Medical Center, Amsterdam, The Netherlands
    Am J Geriatr Psychiatry 20:5-17. 2012
    b>Electroconvulsive therapy (ECT) is the most efficacious treatment in severely depressed elderly patients...
  92. ncbi [Electroconvulsive therapy in major depression: current aspects]
    Paula Barros Antunes
    Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, and Programa de Esquizofrenia, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil
    Rev Bras Psiquiatr 31:S26-33. 2009
    The efficacy of electroconvulsive therapy in treating depressive symptoms has been established by means of innumerable studies developed along the last decades...
  93. ncbi Asystole in ultrabrief pulse electroconvulsive therapy
    Jennifer M Coughlin
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J ECT 28:165-9. 2012
    Ultrabrief (UB) pulse electroconvulsive therapy (ECT) has been gaining popularity in recent years because of its improved cognitive adverse effect profile compared with treatments triggered by brief pulses...
  94. ncbi Rapid relief of severe major depressive disorder by use of preoperative ketamine and electroconvulsive therapy
    Harold W Goforth
    Duke University Medical Center, and Consultation Liaison Psychiatry Service, Durham Veterans Affairs Medical Center, Durham, NC 27710, USA
    J ECT 23:23-5. 2007
    ..marked improvement within 8 hours of receiving a preoperative dose of ketamine and 1 treatment of electroconvulsive therapy with bitemporal electrode placement...
  95. ncbi A review of longitudinal electroconvulsive therapy: neuroimaging investigations
    Christopher C Abbott
    Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM, USA
    J Geriatr Psychiatry Neurol 27:33-46. 2014
    b>Electroconvulsive therapy (ECT) is the most effective treatment for a depressive episode but the mechanism of action and neural correlates of response are poorly understood...
  96. ncbi A case of deep venous thrombosis following protracted catatonic immobility recovered with electroconvulsive therapy: the relevance for an early intervention
    Pierpaolo Medda
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, University of Pisa, Italy
    Gen Hosp Psychiatry 34:209.e5-7. 2012
    ..When this occurs, the prescription of electroconvulsive therapy (ECT), actually irreplaceable in most life-threatening cases, remains controversial essentially due to ..
  97. ncbi [Use of electroconvulsive therapy in psychiatry]
    R Frey
    Klinische Abteilung für Allgemeine Psychiatrie, Universitätsklinik für Psychiatrie, Wahringer Gurtel 18 20, A 1090 Wien
    Nervenarzt 72:661-76. 2001
    b>Electroconvulsive therapy (ECT) has antidepressive and antipsychotic effects. Since being introduced in Italy in 1938, its mode of action has still not been clarified. Treatment modalities have changed in many ways...
  98. ncbi Increased transcranial magnetic motor threshold after ECT. A case report
    Martin Sommer
    Department Psychiatry, University of Gottingen, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 252:250-2. 2002
    b>Electroconvulsive therapy (ECT) is a powerful antidepressive treatment, but its mechanism of action remains poorly understood...
  99. ncbi An examination of mortality and other adverse events related to electroconvulsive therapy using a national adverse event report system
    Bradley V Watts
    Veterans Administration Medical Center, White River Junction, VT, USA
    J ECT 27:105-8. 2011
    There is currently an incomplete understanding of adverse events related to electroconvulsive therapy (ECT) treatments...
  100. ncbi What we have learned about electroconvulsive therapy and its relevance for the practising psychiatrist
    Pascal Sienaert
    ECT Department, University Psychiatric Center Catholic University Leuven, campus Kortenberg, Leuvensesteenweg 517, Kortenberg, Belgium
    Can J Psychiatry 56:5-12. 2011
    In this narrative review, the current knowledge base on the efficacy and the practice of electroconvulsive therapy (ECT) is reviewed, and its relevance for the practising psychiatrist is appreciated...
  101. ncbi Repetitive transcranial magnetic stimulation versus electroconvulsive therapy for major depression: preliminary results of a randomized trial
    Philip G Janicak
    Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
    Biol Psychiatry 51:659-67. 2002
    ..Repetitive transcranial magnetic stimulation (rTMS) has been reported to benefit depression. We compared rTMS to electroconvulsive therapy (ECT) in severely ill, depressed patients.

Research Grants65

  1. Neurocognitive Effects of Convulsive Therapy
    Tammy Moscrip; Fiscal Year: 2004
    ..b>Electroconvulsive therapy (ECT) is the most effective treatment for major depression, but produces anterograde and retrograde ..
  2. Translational Research Evaluating Neurocognitive Memory Processes (TREC-MP)
    Shawn M McClintock; Fiscal Year: 2013
    ..performance, and finally to determine the neurocognitive performance of depressed subjects undergoing electroconvulsive therapy (ECT)...
  3. Role of sFRP3-Dependent Regulation of Adult Neurogenesis in Antidepressant Action
    Mi Hyeon Jang; Fiscal Year: 2013
    ..serves as a substrate for activity-dependent modulation caused by treatment of antidepressant such as electroconvulsive therapy (ECT) and fluoxetine in adult brain...
  4. 2/4-Sustaining Remission of Psychotic Depression
    Anthony J Rothschild; Fiscal Year: 2013
    ..Although electroconvulsive therapy has well-established efficacy in the treatment of PD, its use is limited by several factors...
  5. 4/4-Sustaining Remission of Psychotic Depression
    Alastair J Flint; Fiscal Year: 2013
    ..Although electroconvulsive therapy has well-established efficacy in the treatment of PD, its use is limited by several factors...
  6. 3/4-Sustaining Remission of Psychotic Depression
    Ellen M Whyte; Fiscal Year: 2013
    ..Although electroconvulsive therapy has well-established efficacy in the treatment of PD, its use is limited by several factors...
  7. 1/4-Sustaining Remission of Psychotic Depression
    Barnett Meyers; Fiscal Year: 2013
    ..Although electroconvulsive therapy has well-established efficacy in the treatment of PD, its use is limited by several factors...
  8. Rational Dosing for Electric and Magnetic Seizure Therapy
    ANGEL V PETERCHEV; Fiscal Year: 2013
    ..Despite advances in antidepressant interventions, none has replaced electroconvulsive therapy (ECT) in its acute efficacy and spectrum of action...
  9. Imaging biomarkers of ECT response in major depressive disorder
    Katherine L Narr; Fiscal Year: 2013
    ..b>Electroconvulsive therapy (ECT), used to treat refractory depression, is an established and highly effective procedure eliciting a ..
  10. MEMORY SYSTEMS OF THE MAMMALIAN BRAIN
    Larry R Squire; Fiscal Year: 2013
    ..impairment as it occurs in a variety of psychiatric and neurological conditions and as a side effect of electroconvulsive therapy. The work can provide new tests, the possibility of better and earlier diagnosis, improve understanding ..
  11. Improving Outcomes in Geriatric Depression: Magnetic Seizure Therapy
    Stefan B Rowny; Fiscal Year: 2013
    ..When medications fail, or illness severity demands emergent treatment, Electroconvulsive Therapy (ECT) remains the gold standard, but its use is limited due to risks of cognitive impairment and other ..
  12. Control of Synaptic Glutamate Release
    Steven J Mennerick; Fiscal Year: 2013
    ..adaptive plasticity, may underlie the neural response to clinical brain stimulation treatments such as electroconvulsive therapy and deep-brain stimulation...
  13. Optimization of TMS for Depression
    David Avery; Fiscal Year: 2009
    ..controlled comparisons, five separate meta analyses of these studies, and in randomized trials with electroconvulsive therapy. However, the sample sizes of these studies have been small and the rTMS stimulus administered may not ..
  14. Cognitive Training for Memory Deficits Associated with Electroconvulsive Therapy
    Joan Prudic; Fiscal Year: 2013
    ..Our ultimate goal is to develop a safe and effective behavioral strategy to minimize the adverse memory side effects of ECT so that ECT is a more easily tolerated treatment. ..
  15. Galanin and GaIR2 receptors in antidepressant treatments
    Tamas Bartfai; Fiscal Year: 2005
    ..8 transcripts that are significantly elevated by at least 2 antidepressant treatments, fluoxetine and electroconvulsive therapy, in the rat DRN...
  16. Galanin and GalR2 Receptors in Antidepressant Treatments
    Tamas Bartfai; Fiscal Year: 2009
    ..8 transcripts that are significantly elevated by at least two antidepressant treatments, fluoxetine and electroconvulsive therapy, in the rat DRN...
  17. TMS TREATMENT OF MAJOR DEPRESSION
    David Avery; Fiscal Year: 2002
    ..Unlike electroconvulsive therapy (ETC), one of the most effective treatment for severe depression, rTMS gives a much smaller, ..
  18. MEMORY AS AFFECTED BY INJURY DISEASE AND ECT
    Larry Squire; Fiscal Year: 1999
    ..can occur and also the best ways to measure memory impairment; and 3) to specify the effects of electroconvulsive therapy on memory...
  19. Tryptophan Metabolism, Genes, and Major Depression
    David Steffens; Fiscal Year: 2007
    ..recruited from three sites to ensure broad ranges of severity and prior exposure to antidepressants: the electroconvulsive therapy program, an outpatient mood disorders clinic, and a general internal medicine clinic...
  20. Ginkgo biloba for ECT-induced Memory Deficits
    JOHN MARKOWITZ; Fiscal Year: 2003
    Background: Electroconvulsive therapy (ECT) is a safe and effective modern treatment for severe depression and other specific psychiatric conditions...
  21. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Keith Rasmussen; Fiscal Year: 2005
    b>Electroconvulsive therapy remains an important treatment for severely depressed patients who do not respond adequately to, or are intolerant of, antidepressant medication...
  22. ELECTROCONVULSIVE SHOCK EFFECTS ON BRAIN RECEPTORS
    Kenneth Kellar; Fiscal Year: 1990
    ..This information should contribute to an eventual understanding of the neurochemical effects of ECS and antidepressant drugs and potentially to the rationale for the clinical effects of electroconvulsive therapy.
  23. CONTINUATION ECT VS PHARMACOTHERAPY--EFFICACY AND SAFETY
    Teresa Rummans; Fiscal Year: 2001
    DESCRIPTION (Applicant's abstract): Electroconvulsive therapy (ECT) is a highly effective treatment for major depressive disorder (MDD), that is helpful for patients with the most severe forms of affective illness...
  24. ECT EFFECTS ON CEREBRAL PERFUSION
    MITCHELL NOBLER; Fiscal Year: 2000
    ..the neurophysiological correlates of clinical response in patients with major depression treated with electroconvulsive therapy (ECT) or with nortriptyline...
  25. CONTINUATION PHARMACOTHERAPY FOLLOWING ECT
    Roger Haskett; Fiscal Year: 1999
    b>Electroconvulsive therapy (ECT) is an extremely effective treatment for major depression and patients that receive this modality frequently present with the most severe, recurrent forms of this illness...
  26. ANTIDEPRESSANTS: SIGNAL TRANSDUCTION AND GENE EXPRESSION
    Ronald Duman; Fiscal Year: 1993
    Major depressive illness is alleviated by chronic but not acute administration of antidepressant drugs or electroconvulsive therapy. Although the biochemical mechanisms of antidepressant action are not clearly understood, the delay in ..
  27. IMPROVED THERAPY FOR DEPRESSION
    Emil Pop; Fiscal Year: 1990
    ..None of the available treatment modalities of depression including electroconvulsive therapy and pharmacotherapy mainly by tricyclics and monoamine oxidase inhibitors are totally satisfactory and ..
  28. ERPS AND VERBAL MEMORY IN AGING DEMENTIA AND AMNESIA
    John Olichney; Fiscal Year: 1999
    ..with refractory depression will have a reduced LPC repetition effect when amnesic during the course of electroconvulsive therapy (ECT) but not prior to nor following ECT...
  29. Cocaine, Electroconvulsive Seizure and Neural Plasticity
    BARBARA SORG; Fiscal Year: 2007
    ..b>Electroconvulsive therapy (ECT) or seizure (ECS) is now viewed as successful in treating severe depression because of its ability ..
  30. OPTIMIZATION OF ELECTROCONVULSIVE THERAPY
    Keith Isenberg; Fiscal Year: 2005
    DESCRIPTION: (Adapted from Applicant's Abstract): Patients treated with electroconvulsive therapy typically present with the most severe forms of major depression...
  31. CONTINUATION ECT VS PHARMACOTHERAPY--EFFICACY AND SAFETY
    Georgios Petrides; Fiscal Year: 2003
    ..b>Electroconvulsive therapy (ECT) is a highly effective treatment for major depressive disorder (MDD)...
  32. Continuation ECT vs Pharmacotherapy: Efficacy & Safety
    Teresa Rummans; Fiscal Year: 2003
    ..b>Electroconvulsive therapy (ECT) is a highly effective treatment for major depressive disorder (MDD)...
  33. Electroacupuncture for Major Depression: A Pilot Study
    Benoit Mulsant; Fiscal Year: 2004
    ..for major depression have been developed, including antidepressant pharmacotherapy, psychotherapy, and electroconvulsive therapy. However, many Americans who suffer from a depressive disorder either do not accept to receive one of ..
  34. LONG TERM EFFECTS OF ELECTROCONVULSIVE THERAPY
    Richard Weiner; Fiscal Year: 1991
    ..Test parameters will be as noted above for measurements made at the time of ECT treatments...
  35. ELECTROCONVULSIVE THERAPY: RESEARCH GOALS
    Richard Abrams; Fiscal Year: 1980
    ..Richard Weiner (instrumentation) and others. The questions will be addressed during two two-and-a-half day conferences with the purpose of producing a monograph detailing recommendations for specific projects and their designs. ..
  36. PRACTICE VARIATION AND APPROPRIATENESS IN PSYCHIATRY
    Richard Hermann; Fiscal Year: 2002
    ..Diagnosis-specific utilization rates for psychotherapy, drug treatment, and electroconvulsive therapy (ECT) will be determined for geographic regions using claims from samples of Medicare, Medicaid, and ..
  37. GERIATRIC MENTAL HEALTH ACADEMIC AWARD
    WILLIAM MCCALL; Fiscal Year: 1999
    ..necessary for the principal investigator to develop as a contributing clinical scientist in the areas of electroconvulsive therapy (ECT) and depression in the elderly. Clinical depression occurs commonly in the elderly...
  38. NEUROPSYCHIATRIC ASPECTS OF DEPRESSION IN THE AGING
    Charles Kellner; Fiscal Year: 1992
    ..plan has four main components: 1) training in geriatric medicine; 2) advanced training and research in electroconvulsive therapy, including a specific research proposal entitled, "Weekly versus Three-times-per-week Electroconvulsive ..
  39. OPTIMIZING ECT STIMULUS DOSING USING THE ICTAL EEG
    Andrew Krystal; Fiscal Year: 2002
    ..The research focus is the evaluation of electroconvulsive therapy (ECT) clinical stimulus dosing strategies to improve the tradeoff between treatment efficacy and ..
  40. Hypnotics and the Treatment of Psychiatric Disorders
    WILLIAM MCCALL; Fiscal Year: 2007
    ..abstract_text> ..
  41. DEPRESSION, VULNERABILITY, AND CATECHOLAMINE DEFICIENCY
    Robert Berman; Fiscal Year: 1999
    ..episodes, age of onset, duration of remission, and, previous use of antidepressant medications or electroconvulsive therapy)...
  42. OPTIMIZATION OF ELECTROCONVULSIVE THERAPY
    WILLIAM MCCALL; Fiscal Year: 2005
    DESCRIPTION: (Adapted from Applicant's Abstract): Patients treated with electroconvulsive therapy typically present with the most severe forms of major depression...
  43. Optimization of Transcranial Magnetic Stimulation for Depression
    Sarah Lisanby; Fiscal Year: 2009
    ..controlled comparisons, five separate meta analyses of these studies, and in randomized trials with electroconvulsive therapy. However, the sample sizes of these studies have been small and the rTMS stimulus administered may not ..
  44. MAGNETIC STIMULATION THERAPY: A NEW CONVULSIVE TREATMENT
    Sarah Lisanby; Fiscal Year: 2008
    ..b>Electroconvulsive therapy (ECT) is highly effective for treatment-resistant or intolerant patients, but its cognitive side effects ..
  45. AFFECTIVE AND COGNITIVE CONSEQUENCES OF ECT
    Harold Sackeim; Fiscal Year: 2006
    ..Confirming this benefit and demonstrating that spatial targeting further reduces cognitive burden should have fundamental impact on ECT practice. ..
  46. OPTIMIZATION OF ELECTROCONVULSIVE THERAPY
    Harold Sackeim; Fiscal Year: 2005
    DESCRIPTION: (Adapted from Applicant's Abstract): Patients treated with electroconvulsive therapy typically present with the most severe forms of major depression...
  47. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  48. Optimization of TMS for Depression
    Mark George; Fiscal Year: 2009
    ..controlled comparisons, five separate meta analyses of these studies, and in randomized trials with electroconvulsive therapy. However, the sample sizes of these studies have been small and the rTMS stimulus administered may not ..
  49. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2002
    ..Thus, we plan to use interleaved fMRI and DBS to directly examine the effects of DBS on hypothesized brain circuits and to correlate this with immediate and longer-term (4 week) behavioral outcomes (mood and cognition). ..
  50. Optimization of TMS for Depression - Coordinating Center
    Mark George; Fiscal Year: 2009
    ..controlled comparisons, five separate meta-analyses of these studies, and in randomized trials with electroconvulsive therapy. However, the sample sizes of these studies have been small and the TMS stimulus administered may not ..
  51. ECT IN CLOZAPINE REFRACTORY SCHIZOPHRENIA
    Georgios Petrides; Fiscal Year: 2003
    ..This study will investigate electroconvulsive therapy (ECT) as an augmentation strategy for patients who have failed to adequately respond to clozapine...
  52. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Georgios Petrides; Fiscal Year: 2005
    b>Electroconvulsive therapy remains an important treatment for severely depressed patients who do not respond adequately to, or are intolerant of, antidepressant medication...
  53. COST EFFICIENT TREATMENT OF GERIATRIC DEPRESSION
    William McDonald; Fiscal Year: 2002
    ..this proposal, severely depressed elderly patients will be evaluated, treated with either medication or electroconvulsive therapy (ECT) and followed for 18 months...
  54. Narp Expression and Drugs of Abuse
    Irving Reti; Fiscal Year: 2002
    ..B) Develop methods to manipulate expression of Narp in the VTA using the herpes simplex virus vector system. ..
  55. Treatment with Exercise Augmentation for Depression
    Madhukar Trivedi; Fiscal Year: 2006
    ....
  56. Computerized Decision Support System for Depression
    Madhukar Trivedi; Fiscal Year: 2007
    ..Comparisons will be made between CDSS-D, PPA-D, and UC-D. [unreadable] [unreadable]..
  57. Optimization of TMS for Depression
    William McDonald; Fiscal Year: 2007
    ..controlled comparisons, five separate meta analyses of these studies, and in randomized trials with electroconvulsive therapy. However, the sample sizes of these studies have been small and the rTMS stimulus administered may not ..
  58. REVAMP Follow-Up
    Madhukar Trivedi; Fiscal Year: 2008
    ....