Summary: The study of significant causes and processes in the development of mental illness.

Top Publications

  1. ncbi The emotional Stroop task and psychopathology
    J M Williams
    Department of Psychology, University of Wales, Bangor, Gwynedd
    Psychol Bull 120:3-24. 1996
  2. ncbi Large-scale brain networks and psychopathology: a unifying triple network model
    Vinod Menon
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanfod, CA 94305, USA
    Trends Cogn Sci 15:483-506. 2011
  3. ncbi On inhibition/disinhibition in developmental psychopathology: views from cognitive and personality psychology and a working inhibition taxonomy
    J T Nigg
    Department of Psychology, Michigan State University, East Lansing 48824 1117, USA
    Psychol Bull 126:220-46. 2000
  4. ncbi Network analysis: an integrative approach to the structure of psychopathology
    Denny Borsboom
    Department of Psychology, University of Amsterdam, Amsterdam 1018 XA, The Netherlands
    Annu Rev Clin Psychol 9:91-121. 2013
  5. ncbi Resilience to adult psychopathology following childhood maltreatment: evidence from a community sample
    Stephan Collishaw
    King s College London, MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Child Abuse Negl 31:211-29. 2007
  6. ncbi The antisaccade task as a research tool in psychopathology: a critical review
    Samuel B Hutton
    Department of Psychology, Sussex University, Brighton, UK
    Psychophysiology 43:302-13. 2006
  7. ncbi Cytokines and psychopathology: lessons from interferon-alpha
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biol Psychiatry 56:819-24. 2004
  8. pmc Psychopathology and psychogenic movement disorders
    Sarah Kranick
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 26:1844-50. 2011
  9. ncbi Annual Research Review: Prenatal stress and the origins of psychopathology: an evolutionary perspective
    Vivette Glover
    Institute of Reproductive and Developmental Biology, Imperial College London, UK
    J Child Psychol Psychiatry 52:356-67. 2011
  10. pmc The small world of psychopathology
    Denny Borsboom
    Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e27407. 2011

Detail Information

Publications274 found, 100 shown here

  1. ncbi The emotional Stroop task and psychopathology
    J M Williams
    Department of Psychology, University of Wales, Bangor, Gwynedd
    Psychol Bull 120:3-24. 1996
    Attentional bias is a central feature of many cognitive theories of psychopathology. One of the most frequent methods of investigating such bias has been an emotional analog of the Stroop task...
  2. ncbi Large-scale brain networks and psychopathology: a unifying triple network model
    Vinod Menon
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanfod, CA 94305, USA
    Trends Cogn Sci 15:483-506. 2011
    ..recent conceptual and methodological developments which are contributing to a paradigm shift in the study of psychopathology. I summarize methods for characterizing aberrant brain networks and demonstrate how network analysis provides ..
  3. ncbi On inhibition/disinhibition in developmental psychopathology: views from cognitive and personality psychology and a working inhibition taxonomy
    J T Nigg
    Department of Psychology, Michigan State University, East Lansing 48824 1117, USA
    Psychol Bull 126:220-46. 2000
    Disinhibition is a common focus in psychopathology research. However, use of inhibition models often is piecemeal, lacking an overarching taxonomy of inhibitory processes...
  4. ncbi Network analysis: an integrative approach to the structure of psychopathology
    Denny Borsboom
    Department of Psychology, University of Amsterdam, Amsterdam 1018 XA, The Netherlands
    Annu Rev Clin Psychol 9:91-121. 2013
    In network approaches to psychopathology, disorders result from the causal interplay between symptoms (e.g., worry → insomnia → fatigue), possibly involving feedback loops (e.g...
  5. ncbi Resilience to adult psychopathology following childhood maltreatment: evidence from a community sample
    Stephan Collishaw
    King s College London, MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Child Abuse Negl 31:211-29. 2007
    ..The aims of the present study were to address the extent of resilience to adult psychopathology in a representative community sample, and to explore predictors of a good prognosis.
  6. ncbi The antisaccade task as a research tool in psychopathology: a critical review
    Samuel B Hutton
    Department of Psychology, Sussex University, Brighton, UK
    Psychophysiology 43:302-13. 2006
    ..and neural mechanisms involved in task performance, and review how the task has been applied to study psychopathology. We conclude that the task yields reliable and sensitive measures of the processes involved in resolving the ..
  7. ncbi Cytokines and psychopathology: lessons from interferon-alpha
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biol Psychiatry 56:819-24. 2004
  8. pmc Psychopathology and psychogenic movement disorders
    Sarah Kranick
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 26:1844-50. 2011
    ..A careful psychological assessment is indicated to optimize therapeutic modalities...
  9. ncbi Annual Research Review: Prenatal stress and the origins of psychopathology: an evolutionary perspective
    Vivette Glover
    Institute of Reproductive and Developmental Biology, Imperial College London, UK
    J Child Psychol Psychiatry 52:356-67. 2011
    ..the role of genetics, there is good evidence that prenatal stress exposure can increase the risk for later psychopathology. Why should this be? In our evolutionary history it is possible that some increase in these characteristics ..
  10. pmc The small world of psychopathology
    Denny Borsboom
    Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e27407. 2011
    ..We explain empirical comorbidity patterns based on a network model of psychiatric symptoms, derived from an analysis of symptom overlap in the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV)...
  11. ncbi Rethinking environmental contributions to child and adolescent psychopathology: a meta-analysis of shared environmental influences
    S Alexandra Burt
    Department of Psychology, Michigan State University, East Lansing, MI 48823, USA
    Psychol Bull 135:608-37. 2009
    ..mounting evidence that during childhood and adolescence, c2 may make important contributions to most forms of psychopathology. The aim of the meta-analysis was to empirically confirm this hypothesis...
  12. ncbi Relationships between poverty and psychopathology: a natural experiment
    E Jane Costello
    Developmental Epidemiology Program, Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC 27710, USA
    JAMA 290:2023-9. 2003
    ..Social causation (adversity and stress) vs social selection (downward mobility from familial liability to mental illness) are competing theories about the origins of mental illness...
  13. ncbi Using sex differences in psychopathology to study causal mechanisms: unifying issues and research strategies
    Michael Rutter
    SGDP Centre, Institute of Psychiatry, Kings College, London, UK
    J Child Psychol Psychiatry 44:1092-115. 2003
    ..The review seeks to outline what is known, what are the methodological hazards that must be dealt with, and the research strategies that may be employed...
  14. ncbi Affective style, psychopathology, and resilience: brain mechanisms and plasticity
    R J Davidson
    Department of Psychology, University of Wisconsin Madison, 1202 West Johnson Street, Madison, WI 53706, USA
    Am Psychol 55:1196-214. 2000
    ..Plasticity in this circuitry and its implications for transforming emotion and cultivating positive affect and resilience are considered...
  15. ncbi Inhibitory control and psychopathology: a meta-analysis of studies using the stop signal task
    Jonathan Lipszyc
    Department of Psychiatry, Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Int Neuropsychol Soc 16:1064-76. 2010
    ..This confirms an inhibition deficit in ADHD, and suggests that comorbid ADHD has different effects on inhibition in patients with ANX, ODD/CD, and RD. Further studies are needed to firmly establish an inhibition deficit in OCD and SCZ...
  16. pmc Oiling the brain: a review of randomized controlled trials of omega-3 fatty acids in psychopathology across the lifespan
    Natalie Sinn
    Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Frome Road, Adelaide 5000, Australia
    Nutrients 2:128-70. 2010
    ..This review provides an updated overview of the published and the registered clinical trials that investigate effects of n-3 PUFA supplementation on mental health and behavior, highlighting methodological differences and issues...
  17. ncbi Adolescent subthreshold-depression and anxiety: psychopathology, functional impairment and increased suicide risk
    Judit Balazs
    Vadaskert Child and Adolescent Psychiatric Hospital, Budapest, Hungary
    J Child Psychol Psychiatry 54:670-7. 2013
    ..This study investigates the characteristics of adolescent subthreshold-depression and anxiety with a focus on suicidality, using both categorical and dimensional diagnostic models...
  18. pmc Emotional memory and psychopathology
    J E Ledoux
    Department of Psychology, New York University, NY 10003, USA
    Philos Trans R Soc Lond B Biol Sci 352:1719-26. 1997
    ..Advances in understanding emotional memory hold out the possibility that emotional disorders may be better defined and treatment improved...
  19. pmc Reciprocal relationships between parenting behavior and disruptive psychopathology from childhood through adolescence
    Jeffrey D Burke
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara St, Pittsburgh, PA 15213, USA
    J Abnorm Child Psychol 36:679-92. 2008
  20. ncbi Chronic childhood adversity and onset of psychopathology during three life stages: childhood, adolescence and adulthood
    Corina Benjet
    Department of Epidemiologic and Psychosocial Research, National Institute of Psychiatry Ramon de la Fuente, Mexico City, Mexico
    J Psychiatr Res 44:732-40. 2010
  21. ncbi Measuring adolescent psychopathology: psychometric properties of the self-report strengths and difficulties questionnaire in a sample of Chinese adolescents
    Shuqiao Yao
    Medical Psychological Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    J Adolesc Health 45:55-62. 2009
    The Strengths and Difficulties Questionnaire (SDQ) is a brief but comprehensive screening tool for adolescent psychopathology. The current study examined the psychometric properties of the Chinese version of the self-report form of the ..
  22. pmc Rediscovering psychopathology: the epistemology and phenomenology of the psychiatric object
    Josef Parnas
    Danish National Research Foundation, Center for Subjectivity Research, University of Copenhagen, Denmark
    Schizophr Bull 39:270-7. 2013
    ..In honor of the centenary of Karl Jaspers' book, General Psychopathology, we offer a critique of the contemporary "operationalist" epistemology, a critique that is consistent with ..
  23. pmc Testing the psychosis continuum: differential impact of genetic and nongenetic risk factors and comorbid psychopathology across the entire spectrum of psychosis
    Tolga Binbay
    Department of Psychiatry, Ataturk State Hospital, Sinop, Turkey
    Schizophr Bull 38:992-1002. 2012
    ..Liability associated with respectively affective and nonaffective symptom domains, in interaction with environmental risks, may operate by impacting differentially over a quasi-continuous extended psychosis phenotype in the population...
  24. ncbi Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD): a continuous measure of DSM-IV borderline psychopathology
    Mary C Zanarini
    Department of Psychiatry, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Pers Disord 17:233-42. 2003
    ..Disorder (ZAN-BPD), the first clinician-administered scale for the assessment of change in DSM-IV borderline psychopathology. The questions for the measure were adapted from the BPD module of the Diagnostic Interview for DSM-IV ..
  25. ncbi Emotion regulation and psychopathology: the role of gender
    Susan Nolen-Hoeksema
    Department of Psychology, Yale University, New Haven, Connecticut 06520, USA
    Annu Rev Clin Psychol 8:161-87. 2012
    This review addresses three questions regarding the relationships among gender, emotion regulation, and psychopathology: (a) are there gender differences in emotion regulation strategies, (b) are emotion regulation strategies similarly ..
  26. ncbi Eating patterns in a population-based sample of children aged 5 to 7 years: association with psychopathology and parentally perceived impairment
    Nadia Micali
    Brain and Behavioural Sciences Unit, UCL Institute of Child Health, London, UK
    J Dev Behav Pediatr 32:572-80. 2011
    There is still a lack of research on childhood eating patterns and their correlates in relation to psychopathology and parentally perceived impact in general population samples...
  27. ncbi How we think about cognition, emotion, and biology in psychopathology
    G A Miller
    University of Illinois at Urbana Champaign, USA
    Psychophysiology 33:615-28. 1996
    ..A naively reductionistic view of psychological concepts is prevalent, particularly in the psychopathology literature...
  28. ncbi Coping with stress during childhood and adolescence: problems, progress, and potential in theory and research
    B E Compas
    Department of Psychology, University of Vermont, Burlington 05405, USA
    Psychol Bull 127:87-127. 2001
    ..Studies of the association of coping with symptoms of psychopathology and social and academic competence are reviewed...
  29. ncbi Stress during development: Impact on neuroplasticity and relevance to psychopathology
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Prog Neurobiol 81:197-217. 2007
    ..of exposure to stressful events during prenatal or early postnatal life that might contribute to later psychopathology. The use of the newest methodology in the field and the intensive efforts produced by researchers have opened ..
  30. ncbi Neural correlates of emotion regulation in psychopathology
    Stephan F Taylor
    University of Michigan Department of Psychiatry, 4250 Plymouth Rd, Ann Arbor, MI 48109 5765, USA
    Trends Cogn Sci 11:413-8. 2007
    What can psychopathology and its treatment tell us about cognitive emotional interactions? Standard approaches to interactions between emotion and cognition often adopt a variant of the idea that cognitive processes, subserved by dorsal ..
  31. ncbi The borderline diagnosis I: psychopathology, comorbidity, and personality structure
    Andrew E Skodol
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 51:936-50. 2002
    ..on the current status of the borderline diagnosis and prospects for its future development, we examine the psychopathology, comorbidity, and personality structure of BPD...
  32. ncbi Steroids, neuroactive steroids and neurosteroids in psychopathology
    Bernardo O Dubrovsky
    McGill University, 3445 Drummond Street, 701, Montreal, Quebec, H3G 1X9, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 29:169-92. 2005
    ..The importance of context for the interpretation of behavioral effects of hormones as well as for hormonal levels in body fluids is emphasized. Some suggestions for further research are given...
  33. ncbi Autism spectrum disorders: sex differences in autistic behaviour domains and coexisting psychopathology
    Martin Holtmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, JW Goethe University Frankfurt Main, Germany
    Dev Med Child Neurol 49:361-6. 2007
    ..males and females with autism spectrum disorder (ASD) regarding the core symptoms of autism and coexisting psychopathology. A total of 23 females and 23 males matched for age, IQ, and ASD diagnoses were recruited(mean age 11y 9mo [..
  34. ncbi Early disruption of the mother-infant relationship: effects on brain plasticity and implications for psychopathology
    F Cirulli
    Behavioural Pathophysiology Section, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Neurosci Biobehav Rev 27:73-82. 2003
    ..Changes in the levels of neurotrophic factors during critical developmental stages might result in long-term changes in neuronal plasticity and lead to increased vulnerability to aging and to psychopathology.
  35. ncbi Behavioral inhibition system (BIS), behavioral activation system (BAS) and schizophrenia: relationship with psychopathology and physiology
    Marion R M Scholten
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre, P O Box 85500, 3508 GA Utrecht, Referrence Nr A 00 241, The Netherlands
    J Psychiatr Res 40:638-45. 2006
    ..Imbalance in BIS and BAS levels has been reported to be related to various forms of psychopathology. Since sensitivity to stress has been supposed to be a pathway for the development of psychotic symptoms, the ..
  36. ncbi Psychometric perspectives on diagnostic systems
    Denny Borsboom
    Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018WB Amsterdam, The Netherlands
    J Clin Psychol 64:1089-108. 2008
    ..The author concludes that the psychometric analysis of diagnostic systems is not settled, and that these systems require deeper psychometric analysis than they currently receive...
  37. pmc Neurological abnormalities among offspring of persons with schizophrenia: relation to premorbid psychopathology
    Konasale M Prasad
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Schizophr Res 108:163-9. 2009
    ..We investigated the prevalence, and neurocognitive and psychopathological correlates of NEA among offspring of schizophrenia patients who are at increased genetic risk for this illness...
  38. pmc The use of latent trajectory models in psychopathology research
    Patrick J Curran
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
    J Abnorm Psychol 112:526-44. 2003
    ..individual differences in stability and change over time, these methods are not currently widely used in psychopathology research...
  39. ncbi Putting the person back into psychopathology: an intervention to reduce mental illness stigma in the classroom
    Caroline E Mann
    Psychology Dept, University of Tennessee at Knoxville, Knoxville, TN, USA
    Soc Psychiatry Psychiatr Epidemiol 43:545-51. 2008
    This research aims to compare the effectiveness of two methods of teaching psychopathology in reducing stigma toward mental illness...
  40. ncbi Psychopathology and personality traits in psychotic patients and their first-degree relatives
    M J Cortes
    Unitat de Psiquiatria i Psicologia Mèdica, Department Medicina i Cirurgia, Fac Medicina i Ciències de la Salut, Universitat Rovira i Virgili, C Sant Llorenç 21, 43201 Reus, Spain
    Eur Psychiatry 24:476-82. 2009
    ..The so-called characterial traits like ST would be associated with the appearance of psychotic symptoms...
  41. ncbi Endophenotypes in psychopathology research: where do we stand?
    Gregory A Miller
    Department of Psychology, University of Delaware, Newark, Delaware 19716, USA
    Annu Rev Clin Psychol 9:177-213. 2013
    Endophenotypes for psychopathology have been conceived as latent, unobserved, but measureable manifestations of phenomena that causally connect genetic liability to clinical disorder...
  42. ncbi International epidemiology of child and adolescent psychopathology I: diagnoses, dimensions, and conceptual issues
    Thomas M Achenbach
    Psychology, University of Vermont, 1 South Prospect Street, Burlington, VT 05401, USA
    J Am Acad Child Adolesc Psychiatry 51:1261-72. 2012
  43. pmc Dimensional psychopathology in offspring of parents with bipolar disorder
    Rasim Somer Diler
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Bipolar Disord 13:670-8. 2011
    To compare the dimensional psychopathology in offspring of parents with bipolar disorder (BP) with offspring of community control parents as assessed by the Child Behavior Checklist (CBCL).
  44. ncbi The reliability and validity of discrete and continuous measures of psychopathology: a quantitative review
    Kristian E Markon
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Psychol Bull 137:856-79. 2011
    ..e., dimensional) and discrete (i.e., categorical) measures of psychopathology. Overall, results suggest an expected 15% increase in reliability and 37% increase in validity through ..
  45. ncbi Developing constructs for psychopathology research: research domain criteria
    Charles A Sanislow
    Department of Psychology, Wesleyan University, Middletown, CT 06459, USA
    J Abnorm Psychol 119:631-9. 2010
    ..exists a divide between findings from integrative neuroscience and clinical research focused on mechanisms of psychopathology. Specifically, a clear correspondence does not emerge between clusters of complex clinical symptoms and ..
  46. ncbi The association between psychopathology and substance use in young people: a review of the literature
    Amina Saban
    Department of Psychiatry and Mental Health, and Adolescent Health Research Unit, University of Cape Town, Cape Town, South Africa
    J Psychoactive Drugs 42:37-47. 2010
    This article reviews the recent literature on the association between psychopathology and substance use in young people...
  47. ncbi The roles of persistence and perseveration in psychopathology
    Lucy Serpell
    Department of Clinical, Educational and Health Psychology, University College London and Central and North West London NHS Foundation Trust, London
    Behav Ther 40:260-71. 2009
    ..Persistence was associated with lower levels of psychopathology, whereas perseveration was associated with higher levels of psychopathology...
  48. ncbi How far are associations between child, family and community factors and child psychopathology informant-specific and informant-general?
    Stephan Collishaw
    King s College London Institute of Psychiatry, MRC Social, Genetic, and Developmental Psychiatry Centre, London, UK
    J Child Psychol Psychiatry 50:571-80. 2009
    Assessments of child psychopathology commonly rely on multiple informants, e.g., parents, teachers and children...
  49. pmc Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls
    Renee J Thompson
    Department of Psychology, Stanford University, Stanford, CA, USA
    Psychoneuroendocrinology 36:144-7. 2011
    ..These findings highlight the potential importance of this OXTR gene polymorphism in the etiology of depression and anxiety disorders...
  50. ncbi Benefits and pitfalls in the merging of disciplines: the example of developmental psychopathology and the study of persons with autism
    Jacob A Burack
    Department of Educational Psychology, McGill University, Montreal, Quebec, Canada
    Dev Psychopathol 14:225-37. 2002
    Recent advances in the discipline of developmental psychopathology highlight the contributions of developmental thought to the study of persons with autism...
  51. pmc A modest proposal for another phenomenological approach to psychopathology
    Paul E Mullen
    Victorian Institute of Forensic Mental Health, Monash University, Locked Bag 10, Fairfield, Melbourne, Victoria 3078, Australia
    Schizophr Bull 33:113-21. 2007
    In 1912, Karl Jaspers published an article entitled "The Phenomenological Approach to Psychopathology." This and his subsequent text, General Psychopathology, was to exert a profound influence on the development of psychiatry in general ..
  52. ncbi An evidence-based review of the psychopathology of frontotemporal dementia: a report of the ANPA Committee on Research
    Mario F Mendez
    Department of Neurology and Psychiatry, UCLA, USA
    J Neuropsychiatry Clin Neurosci 20:130-49. 2008
    ..The results of this review highlight the distinct neuropsychiatric manifestations of frontotemporal dementia and the need to reconsider the current diagnostic criteria for this disorder...
  53. ncbi Analyzing psychopathology items: a case for nonparametric item response theory modeling
    Rob R Meijer
    Department of Research Methodology, Measurement and Data Analysis, University of Twente, Enschede, The Netherlands
    Psychol Methods 9:354-68. 2004
    ..item response theory (IRT) models to the construction and psychometric analysis of personality and psychopathology scales, and they contrast these models with parametric IRT models...
  54. ncbi Principal domains of behavioral psychopathology identified by the Bipolar Inventory of Signs and Symptoms Scale (BISS)
    Peter M Thompson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78290 3900, USA
    Psychiatry Res 175:221-6. 2010
    ..Despite the common occurrence of anxiety in BD, it has not been identified in most prior factor analyses, in part due to limited coverage of anxiety symptoms in the source scales...
  55. ncbi Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity
    Nikolaos P Daskalakis
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Physiol Behav 106:707-21. 2012
    In the present study, we tested both the cumulative stress and the mismatch hypothesis of psychopathology. For this purpose the combined effects of early-life adversity and later-life stress exposure on behavioral markers of psychosis ..
  56. ncbi Psychopathology, families, and culture: autism
    Raphael Bernier
    Department of Psychiatry and Behavioral Sciences, University of Washington, Box 357920, Seattle, WA 98195, USA
    Child Adolesc Psychiatr Clin N Am 19:855-67. 2010
    ..In this article, cultural influences on the prevalence of autism and the diagnostic and treatment processes are reviewed and synthesized through a consideration of the developmental context and through clinical practice suggestions...
  57. ncbi The developmental psychopathology of motivation in adolescence
    Graeme Fairchild
    School of Psychology, University of Southampton, Highfield, Southampton, United Kingdom
    Dev Cogn Neurosci 1:414-29. 2011
    Adolescence is a key period for the emergence of psychopathology, with many psychiatric disorders having their modal age-of-onset during this period...
  58. pmc Recovering from early deprivation: attachment mediates effects of caregiving on psychopathology
    Lucy McGoron
    University of New Orleans, USA
    J Am Acad Child Adolesc Psychiatry 51:683-93. 2012
    Children exposed to early institutional rearing are at risk for developing psychopathology. The present investigation examines caregiving quality and the role of attachment security as they relate to symptoms of psychopathology in young ..
  59. ncbi Measures of psychopathology in children with complex partial seizures and primary generalized epilepsy with absence
    D Ott
    Neuropsychiatric Institute, Los Angeles, CA, 90024, USA
    J Am Acad Child Adolesc Psychiatry 40:907-14. 2001
    This investigation examined psychopathology in 48 children with complex partial seizures (CPS), 39 children with primary generalized epilepsy with absence (PGE), and 59 nonepileptic children, aged 5 to 16 years, by comparing the Child ..
  60. ncbi Psychopathology in a large cohort of sexually abused children followed up to 43 years
    Margaret C Cutajar
    Centre for Forensic Behavioural Science, Monash University, 505 Hoddle Street, Clifton Hill, Melbourne, VIC 3068, Australia
    Child Abuse Negl 34:813-22. 2010
    ..To determine the rate and risk of clinical and personality disorders diagnosed in childhood and adulthood in those known to have been sexually abused during childhood...
  61. ncbi Depressive symptoms and psychosocial stress across the transition to parenthood: associations with parental psychopathology and child difficulty
    Sonja Perren
    Department of Child and Adolescent Psychiatry, University of Basel, Switzerland
    J Psychosom Obstet Gynaecol 26:173-83. 2005
    ..Our study investigated differential effects of parental psychopathology and child difficulty on the course of depressive symptoms and feelings of stress for first-time mothers and ..
  62. ncbi Psychopathology in a Swedish population of school children with tic disorders
    Najah Khalifa
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    J Am Acad Child Adolesc Psychiatry 45:1346-53. 2006
    ..To examine patterns of psychiatric comorbid disorders and associated problems in a school population of children with tic disorders...
  63. ncbi Persistent cognitive impairment in depression: the role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation
    Simone Reppermund
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:400-6. 2007
    ..This study examines the associations between HPA system regulation, cognitive functioning, and psychopathology in depressed inpatients on admission and at discharge.
  64. pmc Psychopathology in offspring from families of alcohol dependent female probands: a prospective study
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    J Psychiatr Res 45:285-94. 2011
    ..Multiplex AD families in which multiple cases of AD are present provide an ideal setting for understanding developmental variants of the adult phenotype...
  65. ncbi The Nordic advantage in child mental health: separating health differences from reporting style in a cross-cultural comparison of psychopathology
    Einar Heiervang
    Centre for Child and Adolescent Mental Health, Bergen, Norway
    J Child Psychol Psychiatry 49:678-85. 2008
    The use of similar standardised measures of psychopathology for population surveys permits cross-cultural comparisons. However, interpretation of findings can be challenging because rating thresholds may differ across cultures...
  66. ncbi Specificity of relations between children's control-related beliefs and internalizing and externalizing psychopathology
    S S Han
    Department of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee 37212, USA
    J Consult Clin Psychol 69:240-51. 2001
    ..specificity of the relation between 3 types of control-related beliefs and internalizing and externalizing psychopathology in a sample of 290 clinic-referred children aged 7 to 17 years...
  67. ncbi Implicit measures of association in psychopathology research
    Anne Roefs
    Department of Clinical Psychological Science, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychol Bull 137:149-93. 2011
    ..Text Revision; American Psychiatric Association, 2000) Axis I psychopathology are organized into three categories: (a) studies comparing groups having a disorder with controls, (b) ..
  68. pmc Identification of child maltreatment using prospective and self-report methodologies: a comparison of maltreatment incidence and relation to later psychopathology
    Anne Shaffer
    Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455, USA
    Child Abuse Negl 32:682-92. 2008
    ..The current study compared incidents of maltreatment identified prospectively, retrospectively, or through a combination of both methods...
  69. ncbi Comorbid forms of psychopathology: key patterns and future research directions
    Magdalena Cerda
    Robert Wood Johnson Foundation Health and Society Scholars Program, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Epidemiol Rev 30:155-77. 2008
    The purpose of this review is to systematically appraise the peer-reviewed literature about clustered forms of psychopathology and to present a framework that can be useful for studying comorbid psychiatric disorders...
  70. ncbi The effects of sleep deprivation on symptoms of psychopathology in healthy adults
    Ellen T Kahn-Greene
    Department of Behavioral Biology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research WRAIR, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Sleep Med 8:215-21. 2007
    ..However, the extent to which sleep deprivation may be associated with the emergence of clinical symptoms of psychopathology in healthy normal individuals is not clear.
  71. ncbi Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features
    Alison R Yung
    Department of Psychiatry, University of Melbourne and ORYGEN Research Centre, Australia
    Schizophr Res 67:131-42. 2004
    ..Measures of symptom duration, functioning, disability and psychopathology were made at intake, 6 and 12 months...
  72. ncbi Disturbance of pro-inflammatory cytokines in post-traumatic psychopathology
    A G Sutherland
    Department of Orthopaedics, University of Aberdeen Medical School, Polwarth Building, Foresterhill, AB9 2ZD, Scotland, Aberdeen, UK
    Cytokine 24:219-25. 2003
    Post-traumatic psychopathology (PTP) is important to the orthopaedic surgeon as it may complicate the recovery from musculoskeletal injury...
  73. ncbi Psychopathology in children of Holocaust survivors: a review of the research literature
    N P Kellerman
    AMCHA, National Israeli Center for Psychosocial Support of Holocaust Survivors and the Second Generation, P O B 2930, Jerusalem, 91029, Israel
    Isr J Psychiatry Relat Sci 38:36-46. 2001
    ..The main question involves the presence or absence of specific psychopathology in this population...
  74. ncbi Are psychotic psychopathology and neurocognition orthogonal? A systematic review of their associations
    Maria de Gracia Dominguez
    Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands
    Psychol Bull 135:157-71. 2009
    ..29 to -.12). In contrast, positive and depressive dimensions of psychopathology were not associated with neurocognitive measures...
  75. pmc Childhood adversities and adult psychopathology in the National Comorbidity Survey Replication (NCS-R) III: associations with functional impairment related to DSM-IV disorders
    K A McLaughlin
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Psychol Med 40:847-59. 2010
    ..We report the associations between CAs and functional impairment associated with 12-month DSM-IV disorders in a national sample...
  76. ncbi Parental bonding and adult psychopathology: results from the US National Comorbidity Survey
    M W Enns
    Department of Psychiatry, University of Manitoba, Winnipeg, Canada
    Psychol Med 32:997-1008. 2002
    ..Much of this research, however, has relied on clinical populations with one or two disorders, or has used highly select community samples...
  77. pmc Early adolescent psychopathology as a predictor of alcohol use disorders by young adulthood
    Dustin Pardini
    University of Pittsburgh Medical Center, 201 N Craig St, Sterling Building Suite 408, Pittsburgh, PA 15213, USA
    Drug Alcohol Depend 88:S38-49. 2007
    ..The relative contribution of other forms of adolescent psychopathology (i.e...
  78. ncbi DSM-IV internal construct validity: when a taxonomy meets data
    C A Hartman
    University of Groningen, Faculty of Medical Sciences, Dept of Psychiatry, The Netherlands
    J Child Psychol Psychiatry 42:817-36. 2001
    The use of DSM-IV based questionnaires in child psychopathology is on the increase...
  79. ncbi Psychopathology associated with drinking and alcohol use disorders in the college and general adult populations
    Deborah A Dawson
    U S Department of Health and Human Services, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, NIAAA DBE, Bethesda, MD 20892 7003, USA
    Drug Alcohol Depend 77:139-50. 2005
    ..Factors that may help explain the weaker association of psychopathology and drinking in the college population include selectivity and greater availability of social and treatment ..
  80. ncbi Change in child psychopathology with improvement in parental depression: a systematic review
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Am Acad Child Adolesc Psychiatry 47:379-89. 2008
    To systematically review current research evidence of associations between improvement in parents' depression and their children's psychopathology.
  81. ncbi Panic attacks as a risk for later psychopathology: results from a nationally representative survey
    D Jolene Kinley
    Department of Psychology, University of Manitoba, Winnipeg, MB, Canada
    Depress Anxiety 28:412-9. 2011
    ..suggesting that panic attacks without panic disorder are associated with increases in a wide range of psychopathology and impairment. However, the majority of the literature to date has been cross-sectional...
  82. pmc Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of Ayahuasca: a longitudinal study
    José Carlos Bouso
    Human Experimental Neuropsychopharmacology, IIB Sant Pau, Barcelona, Spain
    PLoS ONE 7:e42421. 2012
    ..ayahuasca use on general psychological well-being, mental health and cognition, here we assessed personality, psychopathology, life attitudes and neuropsychological performance in regular ayahuasca users (n = 127) and controls (n = 115)..
  83. pmc Mother-infant bonding impairment across the first 6 months postpartum: the primacy of psychopathology in women with childhood abuse and neglect histories
    Maria Muzik
    Department of Psychiatry and Depression Center, University of Michigan, Ann Arbor, MI 48109 2701, USA
    Arch Womens Ment Health 16:29-38. 2013 the context of maternal risk, including maternal history of childhood abuse and neglect and postpartum psychopathology, and to test the association between self-reported bonding impairment and observed positive parenting ..
  84. pmc Wisconsin Twin Research: early development, childhood psychopathology, autism, and sensory over-responsivity
    Nicole L Schmidt
    University of Wisconsin, Madison, WI, USA
    Twin Res Hum Genet 16:376-84. 2013
    ..Across the various studies, testing occasions occurred between 3 months and 18 years of age. Data collection for some aspects of the research program has concluded and, for other aspects, longitudinal follow-ups are in progress...
  85. pmc What is bizarre in bizarre delusions? A critical review
    M Cermolacce
    University Department of Psychiatry, Hospital of Sainte Marguerite, University of Marseilles, Marseilles, France
    Schizophr Bull 36:667-79. 2010
    ..The notion of "bizarreness" in schizophrenia is not purely theoretical; it has practical relevance for the therapeutic encounter and implications on further empirical research and on diagnostic approaches...
  86. ncbi Non-medical prescription use increases the risk for the onset and recurrence of psychopathology: results from the National Epidemiological Survey on Alcohol and Related Conditions
    Ty S Schepis
    Department of Psychology, Texas State University, 601 University Drive, San Marcos, TX 78666, USA
    Addiction 106:2146-55. 2011
    ..of the non-medical use of prescription medications (NUPM) and strong cross-sectional associations between psychopathology and NUPM, we examined whether a history of NUPM increased the risk for onset and recurrence of psychopathology...
  87. ncbi Long-term outcomes in borderline psychopathology: old assumptions, current findings, and new directions
    Charles A Sanislow
    Department of Psychology, Wesleyan University, 207 High Street Judd Hall, Middletown, CT 06459, USA
    Curr Psychiatry Rep 14:54-61. 2012
    ..BPD) and historical variants of the diagnosis were long held to represent an intractable syndrome of psychopathology consisting of interpersonal, intrapsychic, and affective disturbances...
  88. pmc Understanding risk for psychopathology through imaging gene-environment interactions
    Luke W Hyde
    Department of Psychology and Center for the Neural Basis of Cognition, University of Pittsburgh, 210 South Bouquet St, Pittsburgh, PA 15260, USA
    Trends Cogn Sci 15:417-27. 2011
    Examining the interplay of genes, experience and the brain is crucial to understanding psychopathology. We review the recent gene-environment interaction (G×E) and imaging genetics literature with the goal of developing models to bridge ..
  89. pmc Trends in psychopathology across the adolescent years: what changes when children become adolescents, and when adolescents become adults?
    E Jane Costello
    Department of Psychiatry and Behavioral Sciences, Center for Developmental Epidemiology, Duke University Medical Center, Durham, NC 27710, USA
    J Child Psychol Psychiatry 52:1015-25. 2011
    ..Little is known about changes in the prevalence of psychiatric disorders between childhood and adolescence, and adolescence and adulthood...
  90. ncbi Eating disorder psychopathology does not predict the overweight severity in subjects seeking weight loss treatment
    Giovanni Castellini
    Psychiatric Unit, Department of Neuropsychiatric Sciences, Florence University School of Medicine, 50134 Firenze, Italy
    Compr Psychiatry 49:359-63. 2008
    ..features of a sample of overweight or obese subjects seeking weight loss treatment and to evaluate the possible, significant associations between the levels of overweight and the specific and general eating disorder psychopathology.
  91. pmc Parental psychopathology and the risk of suicidal behavior in their offspring: results from the World Mental Health surveys
    O Gureje
    Department of Psychiatry, University College Hospital, Ibadan, Nigeria
    Mol Psychiatry 16:1221-33. 2011
    Previous research suggests that parental psychopathology predicts suicidal behavior among offspring; however, the more fine-grained associations between specific parental disorders and distinct stages of the pathway to suicide are not ..
  92. ncbi Alterations of behavioral and endocrinological reactivity induced by 3 brief social defeats in rats: relevance to human psychopathology
    Maria Razzoli
    Neurosciences CEDD, GlaxoSmithKline Medicine Research Centre, 37135 Verona, Italy
    Psychoneuroendocrinology 34:1405-16. 2009
    In the realm of animal models of psychopathology, social stress based procedures rely on robust theoretical prerequisites to meet construct validity criteria for the target syndromes...
  93. ncbi An exploration of competitiveness and caring in relation to psychopathology
    Kirsten McEwan
    Mental Health Research Unit, Kingsway Hospital, Derby, UK
    Br J Clin Psychol 51:19-36. 2012
    ..We hypothesized therefore that depression, in both clinical and non-clinical populations, would be primarily linked to competitive and rank focused sense of self rather than a caring sense of self...
  94. ncbi Psychopathology, coronary heart disease and metabolic syndrome in schizophrenia spectrum patients with deficit versus non-deficit schizophrenia: findings from the CLAMORS study
    Celso Arango
    Psychiatry Department, Hospital General Universitario Gregorio Marañón and Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain
    Eur Neuropsychopharmacol 21:867-75. 2011
    ..8% (95% CI: 8.8-15.5) vs. 6.0% (95% CI: 4.4-8.1), (p<0.05)]. Schizophrenia spectrum patients with DS were more obese and had a higher CHD risk than non-deficit patients...
  95. ncbi Do parental psychopathology and unfavorable family environment predict the persistence of social phobia?
    Susanne Knappe
    Institute of Clinical Psychology and Psychotherapy, Technische Universitaet Dresden, Chemnitzer Str 46, 01187 Dresden, Germany
    J Anxiety Disord 23:986-94. 2009
    Parental psychopathology and unfavorable family environment are established risk factors for onset of offspring social phobia (SP), but their associations with the further course, e.g., persistence of the disorder, remain understudied...
  96. ncbi Antiepileptic drugs and psychopathology of epilepsy: an update
    Marco Mula
    Department of Neurology, Amedeo Avogadro University, Novara, Italy
    Epileptic Disord 11:1-9. 2009
    ..A previous history of psychiatric disorder or a familial predisposition are important risk factors and should be always considered when choosing the appropriate AED...
  97. ncbi Increased prevalence of psychopathology and maladaptive personality traits after long-term cure of Cushing's disease
    Jitske Tiemensma
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Endocrinol Metab 95:E129-41. 2010
    b>Psychopathology and maladaptive personality traits are often observed during the active phase of Cushing's disease (CD)...
  98. pmc Children's perceptions of parental emotional neglect and control and psychopathology
    Robert Young
    MRC Social and Public Health Sciences Unit, Glasgow, UK
    J Child Psychol Psychiatry 52:889-97. 2011
    Parental emotional neglect is linked to psychiatric disorder. This study explores the associations between children's perceptions of parental emotional neglect and future psychopathology.
  99. ncbi Recurrent abdominal pain and headache--psychopathology, life events and family functioning
    M Liakopoulou-Kairis
    Aghia Sophia Children s Hospital, Athens, Greece
    Eur Child Adolesc Psychiatry 11:115-22. 2002
    We assessed the psychopathology of children and adolescents with Recurrent Abdominal Pain (RAP) and tension-type headaches (TTH), the psychopathology and Expressed Emotion (EE) of their mothers and family functioning...
  100. ncbi Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathology
    Juliana Tramontina
    Post Graduate Biochemistry Program, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Bipolar Disord 9:128-35. 2007
    ..a traumatic event or events (TE) have lower brain-derived neurotrophic factor (BDNF) levels and more severe psychopathology as indicated by increased comorbidity and other clinical features when compared to those who were not exposed ..
  101. ncbi Salivary cortisol and psychopathology in children bereaved by the september 11, 2001 terror attacks
    Cynthia R Pfeffer
    Department of Psychiatry, Weill Medical College of Cornell University, New York, 10605 USA
    Biol Psychiatry 61:957-65. 2007
    ..This prospective longitudinal study evaluated relationships among severe psychosocial stress, psychiatric morbidity, and HPA axis function in children...

Research Grants69

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Perinatal Programming of Infant Stress Reactivity and the Atopic Phenotype
    Rosalind J Wright; Fiscal Year: 2013
    ..Non-optimal early caregiving experiences (e.g., maternal psychopathology, maternal insensitivity) may also impact these processes by leading to disrupted infant emotion regulation ..
  3. Appetite-regulating Hormones and Neurocircuitry in Anorexia Nervosa
    ELIZABETH AUSTEN LAWSON; Fiscal Year: 2013
    ..fasting blood draw for hormone levels (eg, ghrelin, PYY);assessment of appetite, mood and disordered eating psychopathology;and fMRI with visual food and non-food stimuli...
  4. Mechanisms Underlying Social Cooperative Behavior
    LUKE JOSEPH CHANG; Fiscal Year: 2010 coursework consists of seminars, practica, and externships that are focused on understanding the nature of psychopathology in psychiatric and neurological disorders and gaining proficiency in the most current empirically supported ..
  5. Risk for Dysfunctional Romantic Relationships for Adults
    Deborah M Capaldi; Fiscal Year: 2013
    ..cause of unhappiness and stress in adulthood and are associated with domestic violence, high divorce rates, psychopathology, and poor health and adjustment for the partners...
    Carolyn E Sartor; Fiscal Year: 2013
    ..research on genetic and environmental contributions to alcohol use and dependence rooted in a developmental psychopathology framework...
  7. Biobehavioral Role of Brain Kynurenine Metabolism in Mental Illness
    JASON C O'CONNOR; Fiscal Year: 2013
    ..experiments are needed to understand the neurobiological mechanisms by which proinflammatory cytokines cause psychopathology and to identify novel therapeutic targets for the treatment of inflammation-induced depression...
  8. RNA editing in a transgenic mouse model of behavioral despair and anxiety.
    Minati Singh; Fiscal Year: 2010
    ..A gain or loss of 5HT2CR as a result of RNA editing is a potential mechanism for generating psychopathology. One of the consequences of ADAR2 RNA editing is alterations in the 5HT2CR...
  9. Models for?functional evaluation of?CHRN polymorphisms
    Beverly H Koller; Fiscal Year: 2012
    ..Recent genetic data suggest that the nACh receptors may play a more complex role in the psychopathology of addiction, and that development of novel therapeutic agents directed at these receptors could be useful ..
  10. Young Development of a Novel PET Ligand for Detecting Oxytocin Receptors in Brain
    Larry J Young; Fiscal Year: 2012
    ..provide an excellent tool to investigate the relationship of OTR distribution, social cognition, and psychopathology. The proposed research plan presents the working hypothesis that a suitable small molecule oxytocin receptor ..
  11. Anorexia Nervosa: Regional Brain Abnormalites and Relationship to Outcome
    LAURIE MAY MCCORMICK; Fiscal Year: 2013 completed with high resolution magnetic resonance imaging along with neuropsychological and personality/psychopathology assessments in young female adults with AN before and after treatment and at 1-year post-hospitalization ..
  12. Intervention for Menstrual Mood Disorders &Early Life Abuse: Biopsych Mechanisms
    Susan S Girdler; Fiscal Year: 2013
    ..MRMDs are associated with high rates of ELA and represent a model of psychopathology whose pathophysiologic underpinnings are linked to ELA...
  13. Ontogenic factors in adolescent-emergent depression and decision-making
    SHANNON LEIGH GOURLEY; Fiscal Year: 2013
    ..and behavioral outcomes after early-life adversity;we will refine novel treatment approaches to depression psychopathology in understudied populations;and we will isolate developmental and molecular mechanisms of core components of ..
  14. Emotion Regulation in Adolescence: A Social Affective Neuroscience Approach
    JENNIFER S contact SILK; Fiscal Year: 2010
    ..This requires an integration of the fields of developmental psychopathology, social neuroscience, and affective neuroscience...
    Amy L Salisbury; Fiscal Year: 2013
    ..with shorter gestation, child sleep problems (shortened sleep cycles, frequent awakening), and child psychopathology. Remission of maternal depression in the infant and child years is associated with fewer problems in ..
  16. Neuromorphometry of Psychosis in Bipolar Disorder
    Daniel Mamah; Fiscal Year: 2013
    ..callosum integrity, 2) compare these measures between PBD, NPBD, SCZ and controls, and 3) correlate lifetime psychopathology with structural abnormalities in PBD and SCZ...
  17. Amygdala CRH, Insomnia and Depression
    Rong Zhang; Fiscal Year: 2012
    ..designed to provide the candidate with skills in circadian biology and sleep regulation, psychophysiology and psychopathology, and genetic epidemiology which are critical in my chosen area of study...
  18. Prenatal androgen effects on sex-related neural processing of reward and threat
    Sheri A Berenbaum; Fiscal Year: 2013
    ..provided by applicant): This project is focused on understanding mechanisms underlying sex differences in psychopathology. We will study effects of sex-differential prenatal androgen exposure on brain and behavioral systems of ..
  19. Axon, Testosterone and Mental Health during Adolescence
    Tomas Paus; Fiscal Year: 2013
    ..The secondary objective is to evaluate the possible impact of such effects on the risk of psychopathology during male adolescence...
  20. Drug Abuse: Sex differences in developmental and environmental influences
    Jill B Becker; Fiscal Year: 2010
    ..consequences of prenatal stress include dysfunction of the stress axis, learning disabilities, depression, psychopathology and potentially an increased propensity to develop drug abuse...
  21. Childhood Maltreatment: Epigenetic Modulation of the Glucocorticoid Receptor
    AUDREY TYRKA; Fiscal Year: 2012
    ..provided by applicant): A history of early-life stress (ELS) is an important risk factor for adult psychopathology, including major depression, anxiety disorders, and substance abuse...
  22. Depression and Insulin Resistance in Adolescents
    LAUREN BERGER SHOMAKER; Fiscal Year: 2012
    ..The PI, Dr. Lauren Shomaker, is a child clinical psychologist whose background in adolescent development/psychopathology, eating behavior, and pediatric obesity/obesity related health co-morbidities is uniquely suited to advance ..
  23. Behavioral Epigenetics
    Barry M Lester; Fiscal Year: 2010
    ..and behavioral outcomes including learning, memory, mental illness, normal development and developmental psychopathology. Prenatal and postnatal factors that produce epigenetic changes in behavior, and the intergenerational ..
  24. Depression and Insulin Resistance in Adolescents
    LAUREN BERGER SHOMAKER; Fiscal Year: 2013
    ..The PI, Dr. Lauren Shomaker, is a child clinical psychologist whose background in adolescent development/psychopathology, eating behavior, and pediatric obesity/obesity- related health co-morbidities is uniquely suited to advance ..
  25. Developmental effects of 5-HTT genotype on stress reactivity and brain function
    Moriah E Thomason; Fiscal Year: 2010 the adult brain that are similar to those that have been found to be associated with various forms of psychopathology (e.g., depression, anxiety disorder, post-traumatic stress disorder)...
  26. Epigenetic modulation of antidepressant efficacy
    Claudia Schmauss; Fiscal Year: 2013
    ..acetylation of histone H4 protein in the frontal cortex, that ameliorates the severity of the adult emotional psychopathology associated with ELS exposure...
    William W Eaton; Fiscal Year: 2013
    ..Area (ECA) cohorts, interviewed from 1979-1983, are the earliest in the nation to include a wide range of psychopathology according to operational diagnostic criteria...
  28. Vermont Center on Behavior and Health
    Stephen T Higgins; Fiscal Year: 2013
    ..and their research topics are: (1) Robert Althoff, MD, PhD, Shared Mechanisms in Child Dysregulation, Adult Psychopathology, and Metabolic Disorders;(2) Diann Gaalema, PhD, Incentives to Improve Cardiac Rehabilitation Participation ..
  29. Genotype-Phenotype Relationships in Fragile X Families
    Randi J Hagerman; Fiscal Year: 2013
    ..of involvement in those with the FMR1 premutation that ranges from developmental problems in childhood and psychopathology in adulthood to neurodegeneration in aging;the latter includes the Fragile X-associated Tremor Ataxia ..
  30. Treatment of Smoking Among Individuals with PTSD
    Edna B Foa; Fiscal Year: 2012
    ..We will also obtain measures of PTSD and associated psychopathology (e.g. depression and anxiety) and risk factors (e.g. anxiety sensitivity)...
  31. Prenatal Smoke Exposure and Offspring Substance Use: An Imaging-Genetics Approach
    Ardesheer Talati; Fiscal Year: 2013
    ..circuits involved in self-regulatory behaviors mediate the association between prenatal smoking and offspring psychopathology (Aim 3)...
  32. Changes in brain function during adolescence and risk for depression in girls
    ..Developmental shifts in neural circuits during adolescence are critical to understanding the emergence of psychopathology during this period...
  33. Functional and Structural Neuroanatomy in Late-Life Generalized Anxiety Disorder
    Carmen Andreescu; Fiscal Year: 2013
    ..This developmental program initiates an integrative strategy for the long-term goal of bridging psychopathology and treatment response with the neuroanatomy of late-life anxiety disorders.
  34. Promoting positive social-emotional pathways: A translational research program
    Grazyna Kochanska; Fiscal Year: 2013
    ..Interdisciplinary team includes experts in socio-emotional development, adolescence, developmental psychopathology, maternal adjustment, intervention science, molecular genetics, and statistics...
  35. 2/2 - Familial Pathways to Early-Onset Suicide Attempts
    JOSEPH JOHN MANN; Fiscal Year: 2013
    ..treatment targets in high-risk families and individuals designed to alter prodromal at-risk behavior and psychopathology and prevent future suicidal behavior...
  36. Effects of Psychopathology on Prefrontal Cortical Functioning During Goal-Directe
    Sharon L Thompson Schill; Fiscal Year: 2010
  37. Essential Features of Neural Damage in Mild Traumatic Brain Injury
    Scott R Sponheim; Fiscal Year: 2012
    ..The clinical presentations of individuals with blast-related brain damage and post-traumatic psychopathology markedly overlap and thus a clear description of the direct consequences of explosive blast is complicated by ..
  38. Brain Mechanisms Mediating Genetic Risk For Anxiety and Depression
    Ned H Kalin; Fiscal Year: 2013
    ..demonstrating the blurred boundary between extreme temperamental anxiety and what is traditionally considered psychopathology. Elucidating the molecular mechanisms underlying extreme AT is essential for efforts aimed at altering the ..
  39. Comparison of two guided self-help treatments for binge eating disorder
    Athena Robinson; Fiscal Year: 2013
    ..g., eating disorder and general psychopathology)...
  40. Eating Disorders and Adolescent Body Image Among Boys and Sexual Minorities
    JEREL PASION CALZO; Fiscal Year: 2012
    ..developing eating disorders, but may also contribute to future weight gain and the development of comorbid psychopathology (e.g., depression)...
  41. Conduct Disorder &Depression in Girls: Precursors, Development and Comorbidity
    Rolf Loeber; Fiscal Year: 2012
    ..depend in large part on the availability of reliable and specific information about the development of psychopathology. Three of the priority areas for clinical research identified in the 2007/2008 NIMH Strategic Plan are the 1) ..
  42. Limbic-Basal Ganglia Circuitry in PTSD
    Ludise Malkova; Fiscal Year: 2013
    ..since the impairment in social interactions and emotional processing generates symptomatology that resembles psychopathology observed in human patients...
  43. Attempted Suicide Candidate Gene Resequencing
    Virginia L Willour; Fiscal Year: 2013 of investigators that includes experts in molecular genetics, statistical genetics, bioinformatics, and psychopathology. Finding genetic variants that influence suicidal behavior would allow for the identification of people with ..
  44. Refining Borderline Personality Disorder Using Flexible Latent Variable Modeling
    ..psychiatric outcomes associated with BPD, the phenotype is not well understood relative to other forms of psychopathology. Improving the construct validity of BPD has been impeded, in part, by the considerable heterogeneity ..
  45. Sensitivity to smoking reinforcement in women: menstrual cycle effects
    Elizabeth Van Voorhees; Fiscal Year: 2012
    ..development of novel treatments tailored to address the unique behavioral and physiological needs of female smokers, particularly those who suffer from comorbid psychopathology associated with dysreguation of reinforcement processes.
  46. Children's Attentional Biases: A Key Component of Negative Valence Systems
    Brandon E Gibb; Fiscal Year: 2013 develop during childhood, stabilize in adolescence, and contribute to the development and maintenance of psychopathology across the lifespan...
  47. Suicide Epigenetics
    Virginia L Willour; Fiscal Year: 2013
    ..assembled an outstanding team of investigators with expertise in epigenetics, genetics, biostatistics, and psychopathology. The identification and characterization of differentially methylated genes and genomic regions in suicidal ..
  48. The Impact of Sleep Deprivation on Affect Regulation in Young Adults
    Peter L Franzen; Fiscal Year: 2011
    ..and early adulthood, as these developmental periods are associated with SD and increased risk for affective psychopathology. Experimental studies consistently find negative effects of SD on self-reported mood in healthy individuals...
  49. Implementation of a Measurement Feedback System in School Mental Health
    AARON ROBERT LYON; Fiscal Year: 2013
    ..Elizabeth McCauley and Jurgen Unutzer have combined expertise in the assessment and treatment of adolescent psychopathology, training with school-based providers, development of computer products to support evidence-based service ..
  50. Brain Norepinephrine and Stress Reactivity
    David A Morilak; Fiscal Year: 2012
    ..This is important to understanding the processes leading to stress-related psychopathology, and the results will hopefully inform the future development of novel strategies for more effective ..
  51. Trajectories of Substance Use and Comorbid Mental Illness
    Magdalena Cerda; Fiscal Year: 2013
    ..has thus far focused on social epidemiology, and through the K-Award, I hope to integrate developmental psychopathology as a core component of my training...
  52. Distress Tolerance and Adolescent Smoking Cessation
    Laura MacPherson; Fiscal Year: 2010
    ..Brown, Mermelstein, Dahl, and Strong (co mentors) are each experts in experimental psychopathology, smoking relapse, adolescent smoking, adolescent affect regulation, and statistics, respectively...
  53. Paternal Care, Affiliation and Vasopressin: Mechanisms of Monogamy
    Alexander G Ophir; Fiscal Year: 2012 autism) and those associated with excessive aggression (such as domestic violence, conduct disorder, or psychopathology)...
  54. Cross-Cultural Comparison of Interactions Between Anxious Mothers and Children
    Araceli Gonzalez; Fiscal Year: 2011
    ..Previous research indicates that parental psychopathology may play a large role in both the development and maintenance of youth anxiety, as well as for the n of ..
  55. Exploring the Neural Circuitry of Deliberate Self Harm in Adolescents
    KATHRYN REGAN CULLEN; Fiscal Year: 2013
    ..These tools allow for the application of systems-based approaches to examining the neural underpinnings of psychopathology, a recent priority in the field...
  56. Serotonin Reuptake Inhibitors and Bone Mineralization in Adolescents
    Chadi A Calarge; Fiscal Year: 2013
    ..A detailed psychiatric assessment will be conducted to control for psychopathology, as a potential confounding factor affecting bone mineralization...
  57. Integrating Genomic and Environmental Perspectives on Internalizing Disorders
    DANIEL E ADKINS; Fiscal Year: 2013
    ..statistical genetics and bioinformatics, and strengthening knowledge of substantive issues in developmental psychopathology and psychometric statistical modeling/programming...
  58. Emotion processing: Risk for psychopathology
    Seth D Pollak; Fiscal Year: 2013
    ..Each of these foci holds tremendous promise for advancement of knowledge and application to improvement of public health. ..
  59. Testing a Comorbid PTSD &Substance/Alcohol Use Intervention in Delinquent Girls
    Amy E Lansing; Fiscal Year: 2013
    ..Juvenile Court, either through the Child Welfare or Juvenile Justice system, demonstrate elevated rates of psychopathology and functional impairment, pose significant social and fiscal costs to society and often escape the attention ..
  60. Impact of Sudden Parental Death on Children and Families
    David A Brent; Fiscal Year: 2012
    ..points in order to examine the relationship between parental loss and child outcomes in the domains of psychopathology (e.g...
  61. Childhood Determinants of Adolescent / Adult Drug Use
    Judith S Brook; Fiscal Year: 2010 accomplish the following: (1) to examine interrelations and interactions of personality (including psychopathology), family, peer, and ecological factors (starting in early childhood) as they affect the course of substance ..
  62. Imaging genetics of extinction of conditioned fear responses in anxiety
    Christine L Larson; Fiscal Year: 2013 to become an independent investigator in the area of imaging genetics of emotion regulation and affective psychopathology. The proposed research and training activities will focus on building expertise in three domains: 1) ..
    KATHRYN KEENAN; Fiscal Year: 2002
    ..The study of infant dysregulation may prove to be a key in understanding the origins of childhood onset psychopathology. Dysregulation of behavior and emotions are among the primary deficits that characterize children's mental ..
  64. Childhood Bilingualism & Developmental Psychopathology
    CLAUDIO TOPPELBERG; Fiscal Year: 2006
    ..of career development, training and research at the interface of two developmental fields: developmental psychopathology and child language acquisition...
    Richard Brown; Fiscal Year: 2000
    ..In the absence of intervention, adolescent smokers with comorbid psychopathology are likely to become highly dependent, recalcitrant adult smokers who have extreme difficulty quitting ..
  66. Bidirectional Relations of Emotionality and Parenting to Child Psychopathology
    CARA JACQUELINE KIFF; Fiscal Year: 2010
    ..provided by applicant): Emotion dysregulation has been identified as a critical factor in the development of psychopathology (Cicchetti, Ackerman, &Izard, 1995), and deficits in emotion regulation are a core component of many ..
  67. Religious engagement and psychopathology over the lifecourse
    Joanna Maselko; Fiscal Year: 2009
    ..The proposed study examines in greater detail the relationship between religious engagement and psychopathology over the life-course by taking advantage of multiple waves of data on both religious engagement and ..
    Wendy Heller; Fiscal Year: 2009 examine the interaction of psychological and neural mechanisms involved in cognitive dysfunction in psychopathology, emphasizing the impact of emotion on attentional processing in anxiety and depression...
  69. Mechanisms conferring risk for psychopathology in stigmatized groups
    MARK HATZENBUEHLER; Fiscal Year: 2009
    ..from clinical and social psychology, the present investigation seeks to understand how stigma contributes to psychopathology. The author proposes a theoretical model hypothesizing that experiences of stigma render individuals more ..