nuclear family

Summary

Summary: A family composed of spouses and their children.

Top Publications

  1. ncbi The family based association test method: strategies for studying general genotype--phenotype associations
    S Horvath
    Institute for Medical Statistics and Genetic Epidemiology, University of Bonn, Bonn, Germany
    Eur J Hum Genet 9:301-6. 2001
  2. pmc Why do low-income minority parents choose human papillomavirus vaccination for their daughters?
    Rebecca B Perkins
    Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA 02118, USA
    J Pediatr 157:617-22. 2010
  3. pmc The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study
    George Davey Smith
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, BS8 2BN
    BMJ 339:b5043. 2009
  4. pmc Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus
    S A Monks
    Department of Biostatistics, University of Washington, Seattle, WA 98195 7232, USA
    Am J Hum Genet 66:576-92. 2000
  5. pmc Longitudinal predictors of human papillomavirus vaccine initiation among adolescent girls in a high-risk geographic area
    Noel T Brewer
    University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA
    Sex Transm Dis 38:197-204. 2011
  6. pmc Association mapping in structured populations
    J K Pritchard
    Department of Statistics, University of Oxford, United Kingdom
    Am J Hum Genet 67:170-81. 2000
  7. ncbi Mothers and daughters: intergenerational patterns of reproduction
    Anneli Pouta
    Department of Public Health Science and General Practice, University of Oulu, Finland
    Eur J Public Health 15:195-9. 2005
  8. ncbi Y-chromosomal microsatellite mutation rates: differences in mutation rate between and within loci
    B Myhre Dupuy
    Institute of Forensic Medicine, University of Oslo, Rikshospitalet, Oslo, Norway
    Hum Mutat 23:117-24. 2004
  9. pmc Common variants in the trichohyalin gene are associated with straight hair in Europeans
    Sarah E Medland
    Queensland Institute of Medical Research, Brisbane 4029, Australia
    Am J Hum Genet 85:750-5. 2009
  10. ncbi Birth weight and adult hypertension, diabetes mellitus, and obesity in US men
    G C Curhan
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 94:3246-50. 1996

Detail Information

Publications256 found, 100 shown here

  1. ncbi The family based association test method: strategies for studying general genotype--phenotype associations
    S Horvath
    Institute for Medical Statistics and Genetic Epidemiology, University of Bonn, Bonn, Germany
    Eur J Hum Genet 9:301-6. 2001
    ..This result allows us to generalise the RC-TDT to dominant, recessive and multi-allelic marker codings. Simulations compare the resulting FBAT tests to the RC-TDT and the S-TDT. The FBAT software is freely available...
  2. pmc Why do low-income minority parents choose human papillomavirus vaccination for their daughters?
    Rebecca B Perkins
    Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA 02118, USA
    J Pediatr 157:617-22. 2010
    ..To explore low-income minority parents' attitudes, intentions, and actions with regard to human papillomavirus (HPV) vaccination for their daughters...
  3. pmc The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study
    George Davey Smith
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, BS8 2BN
    BMJ 339:b5043. 2009
    ..To obtain valid estimates of the association between body mass index (BMI) and mortality by using offspring BMI as an instrumental variable for own BMI...
  4. pmc Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus
    S A Monks
    Department of Biostatistics, University of Washington, Seattle, WA 98195 7232, USA
    Am J Hum Genet 66:576-92. 2000
    ..Finally, we introduce permutation procedures that are recommended for small samples but that can also be used for extensions of the tests to multiallelic markers and to the simultaneous use of more than one marker...
  5. pmc Longitudinal predictors of human papillomavirus vaccine initiation among adolescent girls in a high-risk geographic area
    Noel T Brewer
    University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA
    Sex Transm Dis 38:197-204. 2011
    ..Human papillomavirus (HPV) vaccine uptake is low among adolescent girls in the United States. We sought to identify longitudinal predictors of HPV vaccine initiation in populations at elevated risk for cervical cancer...
  6. pmc Association mapping in structured populations
    J K Pritchard
    Department of Statistics, University of Oxford, United Kingdom
    Am J Hum Genet 67:170-81. 2000
    ..It provides power comparable with the TDT in many settings and may substantially outperform it if there are conflicting associations in different subpopulations...
  7. ncbi Mothers and daughters: intergenerational patterns of reproduction
    Anneli Pouta
    Department of Public Health Science and General Practice, University of Oulu, Finland
    Eur J Public Health 15:195-9. 2005
    ..The objective of this study was to assess intergenerational mother-daughter patterns of reproduction...
  8. ncbi Y-chromosomal microsatellite mutation rates: differences in mutation rate between and within loci
    B Myhre Dupuy
    Institute of Forensic Medicine, University of Oslo, Rikshospitalet, Oslo, Norway
    Hum Mutat 23:117-24. 2004
    ..Our study has thus demonstrated the necessity of not only locus-specific, but even allele-specific, mutation rate estimates for forensic and population genetic purposes, and provides a considerable basis for such estimates...
  9. pmc Common variants in the trichohyalin gene are associated with straight hair in Europeans
    Sarah E Medland
    Queensland Institute of Medical Research, Brisbane 4029, Australia
    Am J Hum Genet 85:750-5. 2009
    ..5x10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations...
  10. ncbi Birth weight and adult hypertension, diabetes mellitus, and obesity in US men
    G C Curhan
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 94:3246-50. 1996
    ..Further study of these diseases in a large cohort with information on a wide variety of risk factors is essential to determine more precisely the risks associated with birth weight...
  11. pmc Anger, PTSD, and the nuclear family: a study of Cambodian refugees
    Devon E Hinton
    Massachusetts General Hospital, Harvard Medical School, Department of Psychiatry, Boston, USA
    Soc Sci Med 69:1387-94. 2009
    ..We focus on the nuclear family (NF) unit, the NF unit defined as the patient's "significant other" (i.e...
  12. pmc Association of MSX1 and TGFB3 with nonsyndromic clefting in humans
    A C Lidral
    Department of Orthodontics, Ohio State University, Columbus, USA
    Am J Hum Genet 63:557-68. 1998
    ..These results form the basis for future research, including (a) mutation searches in the MSX1 and TGFB3 genes in Caucasian CL/P patients and (b) extension of the search for MSX1 mutations in CPO patients to the noncoding regions...
  13. ncbi Determinants and causes of son preference among women delivering in Mansoura, Egypt
    A H el-Gilany
    Department of Community Medicine, Faculty of Medicine, University of Mansoura, Egypt
    East Mediterr Health J 13:119-28. 2007
    ..Achievement of the desired sex, whether son or daughter, was associated with less desire for more children, intention to prolong pregnancy spacing and intention to use contraceptives...
  14. ncbi Genome-wide linkage analysis of Scandinavian affected sib-pairs supports presence of susceptibility loci for celiac disease on chromosomes 5 and 11
    A T Naluai
    Department of Clinical Genetics, Goteborg University, Sweden
    Eur J Hum Genet 9:938-44. 2001
    ..This resulted in significant differences on chromosome 2q. These results indicate that 11q, 5q and possibly also 2q are true susceptibility regions in CD...
  15. pmc A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes
    Heather J Cordell
    Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom
    Am J Hum Genet 70:124-41. 2002
    ..The methods are illustrated using nuclear-family data to evaluate the contribution of loci in the HLA region to the development of type 1 diabetes...
  16. ncbi The association between a family history of type 2 diabetes and coronary artery disease in a type 1 diabetes population
    J R Erbey
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
    Diabetes Care 21:610-4. 1998
    ..Because the etiologies of type 1 and type 2 diabetes are different, it is possible that some CAD in type 1 diabetes may be related to the coexistence of type 2 diabetes susceptibility (i.e., insulin resistance)...
  17. ncbi Tests of linkage and association of the COL1A2 gene with bone phenotypes' variation in Chinese nuclear families
    F Y Deng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    Bone 33:614-9. 2003
    ..Due to the limited number of sib pairs in this sample, we did not find evidence of linkage. In summary, the MspI polymorphism is likely to be in linkage disequilibrium with a nearby functional mutation affecting BMD and bone area...
  18. ncbi Health insurance and the financial impact of IDDM in families with a child with IDDM
    T J Songer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Diabetes Care 20:577-84. 1997
    ..To examine the health insurance experience and out-of-pocket health care costs of families with a child with IDDM...
  19. pmc Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study
    Yan Fang Guo
    Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an, PR China
    J Med Genet 43:798-803. 2006
    ..The low-density lipoprotein receptor-related protein 5 (LRP5) gene, essential for glucose and cholesterol metabolism, may have a role in the aetiology of obesity, an important risk factor for diabetes...
  20. ncbi Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus
    Deborah Smyth
    Juvenile Diabetes Research Foundation JDRF Wellcome Trust WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research CIMR, University of Cambridge, Cambridge, UK
    Diabetes 53:3020-3. 2004
    ..24 x 10(-4); OR 1.43 [95% CI 1.17-1.76]). Taken together, these results indicate a more general association of the PTPN22 locus with autoimmune disease...
  21. ncbi Haplotype association analysis for late onset diseases using nuclear family data
    Chun Li
    Department of Biostatistics, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee 37232 0700, USA
    Genet Epidemiol 30:220-30. 2006
    ..We describe likelihood ratio and permutation tests to test for disease-haplotype association, and describe three test statistics that are potentially useful for detecting such an association...
  22. ncbi Independent confirmation of a major locus for obesity on chromosome 10
    A Hinney
    Department of Child and Adolescent Psychiatry, University of Marburg, FRG
    J Clin Endocrinol Metab 85:2962-5. 2000
    ..05. The linkage results confirm the presence of a major susceptibility locus for obesity in a region near the centromere on chromosome 10...
  23. pmc Statistical tests for detection of misspecified relationships by use of genome-screen data
    M S McPeek
    Department of Statistics, University of Chicago, Chicago, IL, 60637, USA
    Am J Hum Genet 66:1076-94. 2000
    ..We apply the methods to a Genetic Analysis Workshop 11 data set from the Collaborative Study on the Genetics of Alcoholism...
  24. pmc Equivalence of single- and multilocus markers: power to detect linkage with composite markers derived from biallelic loci
    A F Wilson
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    Am J Hum Genet 66:1610-5. 2000
    ..The power to detect linkage with four-locus composite markers was similar to that of a multipoint approach...
  25. ncbi Genetic linkage analysis of complex genetic traits by using affected sibling pairs
    E R Hauser
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biometrics 54:1238-46. 1998
    ..We discuss methods for the genetic analysis of common, complex disease such as diabetes, heart disease or hypertension. We describe the analysis of affected sibling pairs and discuss some of the challenges in applying these methods...
  26. ncbi Association between myostatin gene polymorphisms and peak BMD variation in Chinese nuclear families
    Z L Zhang
    The Department of Osteoporosis, Osteoporosis Research Unit, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, 600 Yi Shan Rd, Shanghai, 200233, People s Republic of China
    Osteoporos Int 19:39-47. 2008
    ..Our results suggest that genetic polymorphisms in myostatin likely play a role in attainment of peak BMD in Chinese women...
  27. pmc Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families
    Jie Mei Gu
    Department of Osteoporosis, Metabolic Bone Disease and Genetics Research Unit, The Shanghai Sixth People s Hospital, Shanghai Jiaotong University, Shanghai, China
    Acta Pharmacol Sin 30:1634-42. 2009
    ....
  28. ncbi Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study
    A G Ziegler
    Diabetes Research Institute and 3rd Medical Department, Krankenhaus München Schwabing, Germany
    Diabetes 48:460-8. 1999
    ..Autoimmunity associated with childhood diabetes is an early event and a dynamic process. Presence of IAAs is a consistent feature of this autoimmunity, and IAA detection can identify children at risk...
  29. ncbi Estrogen receptor alpha gene polymorphisms and peak bone density in Chinese nuclear families
    Yue juan Qin
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Hunan, China
    J Bone Miner Res 18:1028-35. 2003
    ..In conclusion, this study suggests that the ER-alpha gene may have minor effects on PBD variation in our Chinese population...
  30. ncbi Family structure and substance use problems in adolescence and early adulthood: examining explanations for the relationship
    Anne E Barrett
    Dpartment of Sociology, Florida State University, USA
    Addiction 101:109-20. 2006
    ....
  31. ncbi Efficiency of haplotype frequency estimation when nuclear family information is included
    Tim Becker
    Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
    Hum Hered 54:45-53. 2002
    ..We therefore investigated the relative efficiency of haplotype frequency estimation when nuclear family information is included compared to estimation from experimentally derived haplotypes...
  32. pmc A test for linkage and association in general pedigrees: the pedigree disequilibrium test
    E R Martin
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 67:146-54. 2000
    ..Standard methods require selection of a single nuclear family from any extended pedigrees when testing for linkage disequilibrium...
  33. pmc Minimum-recombinant haplotyping in pedigrees
    Dajun Qian
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, CHP 218, Los Angeles, CA 90089, USA
    Am J Hum Genet 70:1434-45. 2002
    ..Haplotyping examples are provided using both published and simulated data sets...
  34. ncbi Risk of diabetes in siblings of index cases with Type 2 diabetes: implications for genetic studies
    C F Weijnen
    Research Division, Joslin Diabetes Center, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Diabet Med 19:41-50. 2002
    ..Because diabetes aetiology involves environmental exposures and genetic susceptibility, we sought to identify determinants of the recurrence risk...
  35. pmc Relationship inference from trios of individuals, in the presence of typing error
    Solveig K Sieberts
    Department of Statistics, University of Washington, Seattle, 98195, USA
    Am J Hum Genet 70:170-80. 2002
    ..It is demonstrated that the coupling of relationship inference and error detection is quite effective, that the error model is computationally practical, and that data on a third relative can often clarify relationships...
  36. pmc Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families
    N J Cox
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 69:820-30. 2001
    ....
  37. pmc Efficient multipoint linkage analysis through reduction of inheritance space
    K Markianos
    Division of Human Biology, Fred Hutchison Cancer Research Center, Seattle, WA 98109, USA
    Am J Hum Genet 68:963-77. 2001
    ..We describe and implement a set of permutation tests that allow determination of empirical significance levels in the presence of linkage disequilibrium among marker loci...
  38. ncbi Ordered subset analysis in genetic linkage mapping of complex traits
    Elizabeth R Hauser
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 27:53-63. 2004
    ..We illustrate this method by analyzing data on breast cancer age of onset and chromosome 17q [Hall et al., 1990, Science 250:1684-1689]. We evaluate OSA using simulation studies under a variety of genetic models...
  39. pmc Haplotype and missing data inference in nuclear families
    Shin Lin
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Genome Res 14:1624-32. 2004
    ..Furthermore, our algorithm can estimate allelic status for missing data at high accuracy (>95%). Finally, the input capacity of the program is vast, easily handling thousands of segregating sites in > or = 1000 chromosomes...
  40. ncbi Maximum-likelihood estimation of haplotype frequencies in nuclear families
    Tim Becker
    Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
    Genet Epidemiol 27:21-32. 2004
    ..We conclude from the simulations that the accuracy of haplotype frequency estimation and reconstruction in nuclear families is very reliable in general and robust against missing genotypes...
  41. pmc A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases
    D Jawaheer
    Division of Biology and Human Genetics, North Shore University Hospital, Manhasset, NY 11030, USA
    Am J Hum Genet 68:927-36. 2001
    ..Therefore, genes in the HLA complex play a major role in RA susceptibility, but several other regions also contribute significantly to overall genetic risk...
  42. pmc A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission
    D Clayton
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom
    Am J Hum Genet 65:1170-7. 1999
    ..The proposed test is a score test based on a partial score function that omits the terms most influenced by hidden population stratification...
  43. pmc A general test of association for quantitative traits in nuclear families
    G R Abecasis
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
    Am J Hum Genet 66:279-92. 2000
    ..Finally, it is shown that, when siblings are available, the total number of genotypes required in order to achieve comparable power is smaller if parents are not genotyped...
  44. ncbi Analysis of mutations in father-son pairs with 17 Y-STR loci
    Amy E Decker
    Biochemical Science Division, National Institute of Sciences and Technology, Gaithersburg, MD 20899 8311, USA
    Forensic Sci Int Genet 2:e31-5. 2008
    ..Furthermore, two different sample pairs were found to have two mutations. An African American sample pair had a mutation at DYS458 and a second at DYS635 and an Asian sample pair had mutations at DYS439 and Y-GATA-H4...
  45. pmc Characteristics and frequency of germline mutations at microsatellite loci from the human Y chromosome, as revealed by direct observation in father/son pairs
    M Kayser
    Max Planck Institut für evolutionäre Anthropologie, D 04103 Leipzig, Germany
    Am J Hum Genet 66:1580-8. 2000
    ..This indicates that the general mutational mechanism of microsatellites is independent of recombination...
  46. pmc Multilocus linkage tests based on affected relative pairs
    H J Cordell
    Department of Medical Genetics, Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, Addenbrookes Hospital, Cambridge, CB2 2XY, England, United Kingdom
    Am J Hum Genet 66:1273-86. 2000
    ..We evaluate the properties of our method by use of simulated data and present an application to real data from families with insulin-dependent diabetes mellitus...
  47. ncbi The well-being of youngsters coming from six different family types
    E Spruijt
    ISED Institute for the Study of Education and Human Development, Faculty of Social Sciences, Utrecht University, The Netherlands
    Patient Educ Couns 45:285-94. 2001
    ..Children of widowed one-parent families do well. In other family types girls suffer a little more from the burden of life than boys. It appears that the effects are hardly different when the children leave home...
  48. ncbi Haplotyping and estimation of haplotype frequencies for closely linked biallelic multilocus genetic phenotypes including nuclear family information
    K Rohde
    Max Delbrueck Centrum for Molecular Medicine, Berlin, Germany
    Hum Mutat 17:289-95. 2001
    ..maximization (EM) algorithm, adapting it to a large number (up to 30) of biallelic loci (SNP), and including nuclear family information, if available, into the analysis. Parents are treated as an independent sample from the population...
  49. ncbi A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma
    Malcolm N Blumenthal
    Department of Medicine, University of Minnesota, MMC 434 Mayo, 420 Delaware SE, Minneapolis, MN 55455, USA
    Hum Genet 114:157-64. 2004
    ..65), 8p (D8S1113, lod=1.60), 12p (D12S372, lod=1.54) and 14q (D14S749, lod=1.70). These results suggest that several regions may harbor genes contributing to the risk for atopy and these may interact with one another in a complex manner...
  50. ncbi Haplotype sharing correlation analysis using family data: a comparison with family-based association test in the presence of allelic heterogeneity
    Dajun Qian
    Department of Biostatistics, City of Hope National Medical Center, Duarte, California 91010 3000, USA
    Genet Epidemiol 27:43-52. 2004
    ..These simulation results suggest that the HSC method has the capacity to identify true disease-associated segments under allelic heterogeneity that go undetected by the FBAT method that compares allelic or haplotypic frequencies...
  51. ncbi Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom
    Kirsten MacKay
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Arthritis Rheum 46:632-9. 2002
    ..To undertake a systematic whole-genome screen to identify regions exhibiting genetic linkage to rheumatoid arthritis (RA)...
  52. pmc A test statistic to detect errors in sib-pair relationships
    M Ehm
    Bioinformatics Group, Glaxo Wellcome, Inc, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 62:181-8. 1998
    ..Furthermore, extreme positive values of the test statistic identify sibs as MZ twins...
  53. ncbi A genome-wide linkage analysis of orchard grass-sensitive childhood seasonal allergic rhinitis in Japanese families
    Y Yokouchi
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan
    Genes Immun 3:9-13. 2002
    ..3, have been previously reported to be linked to asthma and/or atopy. These data suggest that, although loci linked to SAR are likely to be common to asthma, a strong contribution by specific gene(s) to OG-sensitive SAR is unlikely...
  54. ncbi Daughters-in-law in Korean caregiving families
    J S Kim
    Department of Nursing, College of Medicine, Chosun University, Gwangju, South Korea
    J Adv Nurs 36:399-408. 2001
    ..The aim of this study was to examine the emotional and physical health and experiences of daughter-in-law (DIL) caregivers compared with daughter caregivers who care for cognitively and/or functionally impaired older people in Korea...
  55. ncbi Testing candidate genes for non-syndromic oral clefts using a case-parent trio design
    Terri H Beaty
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Genet Epidemiol 22:1-11. 2002
    ..03). Using a conditional logistic model to test for gene-gene interaction showed no evidence of interaction between TGFbeta3 and MSX1, with both seeming to contribute independently to risk of isolated, non-syndromic oral clefts...
  56. ncbi Association between SNP and haplotypes in PPARGC1 and adiponectin genes and bone mineral density in Chinese nuclear families
    Zhen Lin Zhang
    Department of Osteoporosis, Osteoporosis Research Unit, Affiliated Sixth People s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
    Acta Pharmacol Sin 28:287-95. 2007
    ....
  57. pmc Comparison of tests for association and linkage in incomplete families
    A C Cervino
    The Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
    Am J Hum Genet 67:120-32. 2000
    ..Under various dominant models, SIBASSOC/STDT was slightly more powerful than TRANSMIT. Misclassification of the disease status of healthy sibs, as well as the discarding of incomplete families, resulted in a consistent loss of power...
  58. pmc Using discordant sib pairs to map loci for qualitative traits with high sibling recurrence risk
    J J Rogus
    Joslin Diabetes Center, Section on Epidemiology and Genetics, Boston, MA 02215
    Am J Hum Genet 59:1376-81. 1996
    ..Following the diabetic nephropathy example, we consider more systematically the situations in which DSPs can provide an efficient alternative to ASPs...
  59. pmc Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity
    W K Scott
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Hum Genet 66:922-32. 2000
    ..When considering all possible affected sib pairs (ASPs) per nuclear family, we obtained a peak maximum LOD score between D12S1057 and D12S1042...
  60. ncbi Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes
    R Hermann
    JDRF Centre for Prevention of Type 1 Diabetes in Finland, Turku, Finland
    Diabetologia 49:1198-208. 2006
    ..We also explored the heterogeneity in the disease-predisposing effect of this polymorphism in relation to known disease loci, sex and age at disease onset...
  61. ncbi Genome scan for childhood and adolescent obesity in German families
    Kathrin Saar
    Molecular Genetics and Gene Mapping Center, Max Delbruck Center, Berlin, Germany
    Pediatrics 111:321-7. 2003
    ....
  62. pmc SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families
    S H Kollins
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1580-8. 2008
    ..Results also shed light on the molecular genetic basis of specific processes that may underlie the disorder...
  63. pmc A comparative study of sibship tests of linkage and/or association
    S A Monks
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 63:1507-16. 1998
    ..We also examine the consequences of having some parental data in the sample...
  64. ncbi Clinical phenotype of schizophrenia in a Finnish isolate
    Ritva Arajärvi
    Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, Helsinki 00300, Finland
    Schizophr Res 67:195-205. 2004
    ..Findings in this schizophrenia OCCPI phenotype study suggest that the clinical picture of schizophrenia in a genetically isolated and homogeneous population closely resembles our nationwide findings in Finland...
  65. ncbi Association between the FOXP2 gene and autistic disorder in Chinese population
    Xiaohong Gong
    Institute of Mental Health, Peking University, Beijing, China
    Am J Med Genet B Neuropsychiatr Genet 127:113-6. 2004
    ..Our findings suggest that the FOXP2 gene may be involved in the pathogenesis of autism in Chinese population...
  66. ncbi Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism
    Katsuhiko Nishimura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Biochem Biophys Res Commun 356:200-6. 2007
    ..We suggest that BDNF has a possible role in the pathogenesis of autism through its neurotrophic effects on the serotonergic system...
  67. ncbi Method for using complete and incomplete trios to identify genes related to a quantitative trait
    Emily O Kistner
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Genet Epidemiol 27:33-42. 2004
    ..In addition, missing parental genotype data can be accommodated through an expectation-maximization (EM) algorithm approach. The EM approach allows recovery of most of the lost power due to incomplete trios...
  68. ncbi Polymorphic variation in the CBLB gene in human type 1 diabetes
    R Kosoy
    Molecular Genetics Program, Benaroya Research Institute, Seattle, WA 98101, USA
    Genes Immun 5:232-5. 2004
    ..No significant evidence of association was obtained for either individual markers or marker haplotypes...
  69. ncbi A family-based likelihood ratio test for general pedigree structures that allows for genotyping error and missing data
    Yang Yang
    Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA
    Hum Hered 66:99-110. 2008
    ..We derive the conditional likelihood functions of the general nuclear family for the following scenarios: complete parental genotype data and no genotyping errors; only one genotyped ..
  70. ncbi Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders
    Emma L Dempster
    Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada
    Arch Gen Psychiatry 64:1189-95. 2007
    ..Arginine vasopressin (AVP) plays a crucial role in modulating the HPA axis under stress and does so through a G protein-coupled receptor, vasopressin V1b receptor (AVPR1b)...
  71. pmc Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene
    Rebecca C J Twells
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, UK
    Genome Res 13:845-55. 2003
    ..The identification of hot spots in between these LD blocks provides additional evidence that LD blocks are separated by areas of higher recombination...
  72. ncbi A general class of association tests for family-based data using weight functions
    Xin Liu
    Laboratory of Statistical Genetics, Rockefeller University, New York, New York 10021, USA
    Genet Epidemiol 24:208-19. 2003
    ..For the sitosterolemia data set, the association test has its most significant result (P-value=0.0012) for the marker locus on the same bacterial artificial chromosome as the disease locus...
  73. ncbi Multipoint linkage disequilibrium mapping for complex diseases
    Kung Yee Liang
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Genet Epidemiol 25:285-92. 2003
    ..Furthermore, such discrepancy in preferential transmission was most evident among probands with early onset age (6 years old or younger)...
  74. ncbi Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism
    Qiujin Qian
    Institute of Mental Health, Peking University, Beijing 100083, People s Republic of China
    Am J Med Genet B Neuropsychiatr Genet 118:103-9. 2003
    ..Although these results suggest the COMT gene exerts some influence on the risk for ADHD in the Han Chinese population, given the potential for Type I error, these findings require replication before drawing definitive conclusions...
  75. ncbi Interleukin-1beta (IL-1beta) gene and increased risk for the depressive symptom-dimension in schizophrenia spectrum disorders
    Araceli Rosa
    Unitat d Antropologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Am J Med Genet B Neuropsychiatr Genet 124:10-4. 2004
    ..07). This tendency was not observed in the healthy offspring. Using a multidimensional symptom approach to the diagnosis, the association was confirmed in psychotic patients showing the depressive symptom-dimension (P = 0.02)...
  76. ncbi Association analysis of the HOPA12bp polymorphism in schizophrenia and manic depressive illness
    George Kirov
    Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff CF144 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 118:16-9. 2003
    ..6%, P = 0.6. We conclude that the HOPA polymorphism is unlikely to be a major risk factor in the pathogenesis of these major psychiatric disorders although there could be a small effect in schizophrenia...
  77. ncbi Fine-scale mapping at IGAD1 and genome-wide genetic linkage analysis implicate HLA-DQ/DR as a major susceptibility locus in selective IgA deficiency and common variable immunodeficiency
    Jana Kralovicova
    Division of Human Genetics, School of Medicine, Southampton University Hospital, University of Southampton, Southampton, United Kingdom
    J Immunol 170:2765-75. 2003
    ..IgAD/CVID may thus provide a useful model for the study of pathogenesis and novel therapeutic strategies in autoimmune diseases...
  78. ncbi Two-stage association tests for genome-wide association studies based on family data with arbitrary family structure
    Tao Feng
    Department of Mathematical Sciences, Michigan Technological University, Houghton, MI 49931, USA
    Eur J Hum Genet 15:1169-75. 2007
    ..Also, by carefully choosing the number of markers retained in the first stage, the power of a two-stage approach can be much more than that of the corresponding one-stage approach...
  79. ncbi Myelin oligodendrocyte glycoprotein (MOG) gene is associated with obsessive-compulsive disorder
    Gwyneth Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Am J Med Genet B Neuropsychiatr Genet 129:64-8. 2004
    ..334, P = 0.020). Further investigations combining genetic, pathological, and pharmacological strategies, are warranted...
  80. ncbi Screening for new MTHFR polymorphisms and NTD risk
    Valerie B O'Leary
    Department of Biochemistry, Trinity College Dublin, Dublin, Ireland
    Am J Med Genet A 138:99-106. 2005
    ..This is the first NTD association study of both R594Q and the novel P39P. The association with NTD risk reported for these SNPs is driven by the linkage disequilibrium with the A222V (677C->T) NTD risk factor...
  81. ncbi Type I error rates in association versus joint linkage/association tests in related individuals
    Jack W Kent
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Genet Epidemiol 31:173-7. 2007
    ..These results support the idea that an appropriate association analysis must test both the random effect of shared marker alleles (linkage) and the mean effects of the marker genotypes (association)...
  82. ncbi Cytosolic PLA2 genes possibly contribute to the etiology of schizophrenia
    Ran Tao
    Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun, China
    Am J Med Genet B Neuropsychiatr Genet 137:56-8. 2005
    ..93, df = 6, P = 0.0008). These findings suggest that these three cPLA2 genes may all be involved in contributing to the etiology of schizophrenia although their effect size appears to be relatively small...
  83. ncbi A method for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parents
    Emily O Kistner
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Genet Epidemiol 29:155-65. 2005
    ..We use simulations based on a population with admixture to compare our method to a popular non-parametric family-based association test (FBAT), testing the null of no association in the presence of linkage...
  84. ncbi Transmission disequilibrium and haplotype analyses of the G72/G30 locus: suggestive linkage to schizophrenia in Palestinian Arabs living in the North of Israel
    M Korostishevsky
    Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel 69978
    Am J Med Genet B Neuropsychiatr Genet 141:91-5. 2006
    ..These data suggest a common risk factor for schizophrenia susceptibility in the G72/G30 locus among Ashkenazi Jews and Palestinian Arabs. The results strengthen previous reports on the role of this locus in the etiology of schizophrenia...
  85. ncbi [Association between serotonin 1D gene polymorphisms and attention deficit hyperactivity disorder comorbid or not comorbid disruptive behavior disorder]
    Jun Li
    Peking University Institute of Mental Health, Beijing 100083, China
    Beijing Da Xue Xue Bao 38:492-5. 2006
    ..To investigate the relationship between two HTR1D gene polymorphisms, that is 1350T > C and 1236A > G polymorphisms, and attention deficit hyperactivity disorder (ADHD) comorbid or not comorbid disruptive behavior disorder (DBD)...
  86. ncbi Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations
    T H Beaty
    Johns Hopkins University, Baltimore, MD, USA
    Hum Genet 120:501-18. 2006
    ....
  87. ncbi Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate
    Barbara Kremeyer
    Galton Laboratory, Department of Biology, University College London, London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 141:435-9. 2006
    ..7, P = 0.025) with an excess transmission of a haplotype comprising the rs6265 G allele and microsatellite allele 227. These results are consistent with previous studies pointing to a role for BDNF in susceptibility to mood disorders...
  88. pmc Association analyses of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear families
    Tie Lin Yang
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, People s Republic of China
    Hum Genet 120:119-25. 2006
    ..We thus concluded that CYP19 could be one of the genetic factors influencing adult height in Caucasians. Further studies are required to identify the causal functional variants responsible for Caucasian height within the CYP19 gene...
  89. ncbi Variable contribution of the MTHFR C677T polymorphism to non-syndromic cleft lip and palate risk in China
    JiangHui Zhu
    Institute of Reproductive Health, Peking University Health Science Center, Beijing, China
    Am J Med Genet A 140:551-7. 2006
    ..Thus, the MTHFR polymorphism is a significant risk factor for nsCL/P in this Northern Chinese population. Our study suggested possible genetic heterogeneity in the development of nsCL/P among Northern and Southern populations in China...
  90. ncbi Association of the DAT1 polymorphism with attention deficit hyperactivity disorder (ADHD): a family-based approach
    Myung Ho Lim
    Department of Psychiatry, College of Medicine, Dankook University, Cheonan, Korea
    Am J Med Genet B Neuropsychiatr Genet 141:309-11. 2006
    ..001; OR = 7.88, CI = 2.20-28.29). These data support the role of DAT1 in ADHD susceptibility among Asian populations...
  91. ncbi Loss of function polymorphisms in NAT1 protect against spina bifida
    Liselotte E Jensen
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Hum Genet 120:52-7. 2006
    ....
  92. ncbi MICA gene polymorphism in HBDI multiplex families
    Liene Nikitina-Zake
    Immunogenetics, Department of Molecular Medicine, CMM L8 00, Karolinska sjukhuset, K1, 17176, Stockholm, Sweden
    Ann N Y Acad Sci 1037:150-6. 2004
    ..However, this latter analysis should be repeated on a larger family sample...
  93. ncbi Covariate adjustment in family-based association studies
    Alice S Whittemore
    Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA
    Genet Epidemiol 28:244-55. 2005
    ..e., data for which multiple logistic regression of matched sibships would have little power. Software for performing the covariate-adjusted tests is available at http://www.stanford.edu/dept/HRP/epidemiology/COVTDT...
  94. ncbi Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability
    D W Morris
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 129:97-103. 2004
    ..As these are the only clear cut functional candidate genes in the region, identification of the putative susceptibility locus for RD on 15q will require more methodical non-hypothesis driven positional cloning approaches...
  95. ncbi Association study of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and childhood-onset mood disorders
    Jennifer H Adams
    Department of Psychiatry, Cell and Molecular Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 132:90-5. 2005
    ..Based on these results, using these three polymorphisms, we do not find support for NTRK2 as a susceptibility gene for COMD...
  96. ncbi Association of a TNAP haplotype with ankylosing spondylitis
    Hing Wo Tsui
    Toronto Western Research Institute, Toronto, Ontario, Canada
    Arthritis Rheum 56:234-43. 2007
    ..To use a candidate gene approach to the identification of genetic markers that are significantly associated with ankylosing spondylitis (AS)...
  97. ncbi Informative-transmission disequilibrium test (i-TDT): combined linkage and association mapping that includes unaffected offspring as well as affected offspring
    Chao Yu Guo
    Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Genet Epidemiol 31:115-33. 2007
    ..Applying the i-TDT to the Framingham Heart Study data, we found that the apolipoprotein E (APOE) gene is significantly linked and associated with cross-sectional measures and longitudinal changes in total cholesterol...
  98. ncbi Association analysis of NOTCH 4 polymorphisms with schizophrenia among two independent family based samples
    S Prasad
    Department of Genetics, University of Delhi, South Campus, Benito Juarez Road, New Delhi, India
    Am J Med Genet B Neuropsychiatr Genet 131:6-9. 2004
    ..Transmission distortion, consistent with a modest association was detected among both samples. Additional association studies at this locus are warranted...
  99. ncbi Linkage disequilibrium mapping of bipolar affective disorder at 12q23-q24 provides evidence for association at CUX2 and FLJ32356
    Beate Glaser
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Wales, UK
    Am J Med Genet B Neuropsychiatr Genet 132:38-45. 2005
    ..Our data provide evidence for association between bipolar mood disorder and markers on chromosome 12q23-q24 but need replication in independent samples...
  100. ncbi Family-based association study between autism and glutamate receptor 6 gene in Chinese Han trios
    Mei Shuang
    Institute of Mental Health, Peking University, Beijing, China
    Am J Med Genet B Neuropsychiatr Genet 131:48-50. 2004
    ..032). The global chi(2) test for haplotype transmission also revealed an association between GluR6 and autism (chi(2) = 10.78, df = 3, P = 0.013). Our results suggested that GluR6 is in linkage disequilibrium with autism...
  101. ncbi Interpretation of simultaneous linkage and family-based association tests in genome screens
    Ren Hua Chung
    Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27710, USA
    Genet Epidemiol 31:134-42. 2007
    ..We concluded that when linkage and association tests are applied in the same data, the type I error rate of neither test will be affected and that power can be increased by applying tests conditionally...

Research Grants75

  1. GENETICS OF CAENORHABDITIS ELEGANS SPERM MORPHOGENESIS
    STEVEN L HERNAULT; Fiscal Year: 2003
    ..Additionally, C. elegans spermatogenesis is the best model for this process in the many medically and agriculturally important parasitic nematodes that are difficult to study in the laboratory. ..
  2. Infant Screening and Diagnosis of Duchenne Muscular Dys*
    Paul Fernhoff; Fiscal Year: 2007
    ..These data points will be tracked throughout the project. ..
  3. Transgenerational effects of maternal high fat diet during pregnancy on breast ca
    Leena A Hilakivi-Clarke; Fiscal Year: 2013
    ....
  4. Estrogen-T cell Interactions
    Prakash S Nagarkatti; Fiscal Year: 2013
    ..Thus, our studies are aimed at providing insights into the mechanism by which estrogens mediate their toxic effects on the immune system, thereby leading to the development of strategies for their prevention and treatment. ..
  5. A Developmental And Molecular Investigation Of How Vitamin E Ameliorates Endocrin
    Krista McCoy; Fiscal Year: 2013
    ....
  6. Perinatal Exposure to Environmental DDT and Risk of Metabolic Syndrome
    Michele La Merrill; Fiscal Year: 2012
    ..The ultimate goal of this work is to understand the possible contribution of DDT to metabolic syndrome and to use this information to design strategies for the prevention of metabolic syndrome. ..
  7. Somatic stem cells in the Drosophila ovary
    DANIEL D KALDERON; Fiscal Year: 2013
    ..Our findings will uncover basic principles of stem cell regulation that are directly relevant and of critical significance to our understanding of how to harness human stem cells in medicine and how to combat cancer. ..
  8. Older Mothers and Adult Daughters: High Blood Pressure Self Management Behaviors
    Celeste Shawler; Fiscal Year: 2010
    ..The candidate plans to further examine the significance of inner strength and modifiable health behaviors of older women with hypertension. ..
  9. Reducing HIV Risk in Adult Women with Intellectual Disabilities
    JENNIFER J WELLS; Fiscal Year: 2012
    ....
  10. Womb to womb: Programming reproductive development in the female marmoset monkey
    Julienne N Rutherford; Fiscal Year: 2013
    ....
  11. How do you build a parasite?
    John Murray; Fiscal Year: 2009
    ..We aim to determine what proteins are needed, the function of each protein, and how they are arranged in 3D to provide the scaffold for building a parasite. ..
  12. Early Life Determinants of Accelerated Pubertal Development in Adolescent Girls
    Ai Kubo; Fiscal Year: 2013
    ..Kubo to develop successful R01 research to further elucidate early life determinants of pubertal onset and other cancer risk factors. ..
  13. Organochlorine and Gene Expression of Sex Steroids in a Multigenerational Cohort
    Janet Rose Osuch; Fiscal Year: 2011
    ..This will allow us to explore the possibility of the inheritance of transgenerational epigenetic modification in humans. ..
  14. Decision Making in Unaffected First-Degree Relatives of Prostate Cancer Patients
    Clement Gwede; Fiscal Year: 2009
    ..We seek to develop a decision aid (educational DVD) to help men with a positive family history of prostate cancer make informed decisions about testing, with the ultimate goal of reducing the burden of prostate cancer. ..
  15. An Integrated HIV Prevention Model for African American Mothers and Daughters
    Geri R Donenberg; Fiscal Year: 2013
    ..Effective family-based programs can alter negative developmental trajectories of this very high-risk population and begin to redress existing health disparities. ..
  16. Cytoskeleton polymerization dynamics in the cell cycle
    Timothy J Mitchison; Fiscal Year: 2010
    ..Understanding midbody assembles will reveal principles for generating asymmetric assemblies in the cytoplasm, and will tell us how the cleavage furrow is positioned. ..
  17. MOLECULAR MECHANISMS AND MODULATION OF GLIAL ACTIVATION
    Linda Van Eldik; Fiscal Year: 2009
    ..Multipoint linkage analysis using variance components methods will be applied to nuclear family data to search for QTLs influencing obesity-related phenotypes in Hispanic children...
  18. Progenitor Cells in Lung Development and Repair
    Brigid L M Hogan; Fiscal Year: 2013
    ..In the long term the work may lead to potential therapies or predictive assays for pathological conditions related to defects in the supply, proliferation or differentiation of progenitor/stem cells in the human lung. ..
  19. Perinatal Exposure to Environmental DDT and Risk of Metabolic Syndrome
    Michele La Merrill; Fiscal Year: 2013
    ..abstract_text> ..
  20. PEDIGREE: Prenatal Environmental Determinants of InterGenerational Risk
    Mary Beth Terry; Fiscal Year: 2013
    ....
  21. MI Youth Violence Prevention Center
    Marc A Zimmerman; Fiscal Year: 2013
    ..We will conduct a process evaluation of the component programs to assure their intended effects are realized and an overall evaluation of the Center. ..
  22. A Text Message Intervention to Increase HPV Vaccine Completion in Young Latinas
    Angelica M Roncancio; Fiscal Year: 2013
    ..abstract_text> ..
  23. TAS::75 0849::TAS CONTINUATION OF FOLLOW-UP OF DES-EXPOSED COHORT
    ARTHUR HERBST; Fiscal Year: 2010
    ..abstract_text> ..
  24. TAS::75 0849::TAS CONTINUATION OF FOLLOW-UP OF DES-EXPOSED COHORTS
    Linda Titus Ernstoff; Fiscal Year: 2010
    ..abstract_text> ..
  25. Unidas por la Vida: Testing a family-based intervention among high-risk Latinas
    Dara H Sorkin; Fiscal Year: 2010
    ....
  26. Social Network Influences on Values Related to Parental HPV Vaccine Refusal
    Linda Y Fu; Fiscal Year: 2013
    ....
  27. Empowering Daughters and Mother-in-laws to Mitigate Gender-based Violence and Pro
    Suneeta Krishnan; Fiscal Year: 2011
    ..It is expected that the study findings will provide evidence to determine if a phase 3 effectiveness trial is merited and advance the science underlying GBV prevention. ..
  28. Optimizing HPV Vaccination: Parents, Providers and Pre-teen Boys
    JOAN ROBERTS CATES; Fiscal Year: 2013
    ..We anticipate the research will yield effective dissemination strategies that can be broadly used to reduce HPV infection in males, especially racial and ethnic populations. ..
  29. Mother-Daughter Joint Decision Making to Obtain the HPV Vaccine
    Julia Lechuga; Fiscal Year: 2013
    ..In addition, information gathered in our studies can be translated to promote uptake of the HPV vaccine by health care practitioners impacting directly the field of nursing science. ..
  30. Using Maternal Cancer Screening Visits to Improve Adolescent HPV Vaccination
    Ruth C Carlos; Fiscal Year: 2010
    ....
  31. Asymmetric chromosome strand inheritance during stem cell division in Drosophila
    Swathi Yadlapalli; Fiscal Year: 2013
    ....
  32. Compassion Fatigue in Adult Daughter Caregivers
    Jennifer Day; Fiscal Year: 2012
    ..Next research steps will explore trajectories of compassion fatigue and develop instruments to measure and screen for compassion fatigue. ..
  33. Modeling epithelial stem cell competition in a dynamic Drosophila ovarian niche
    TODD GREGORY NYSTUL; Fiscal Year: 2013
    ..Ultimately, it will provide a foundation for understanding conserved mechanisms of in vivo epithelial stem cell regulation. ..
  34. The Genetics and Genomics of Sex-Ratio Meiotic Drive in Drosophila Affinis
    Robert L Unckless; Fiscal Year: 2013
    ..The biological insight obtaine from our analysis may shed light on the genetics of sex-ratio meiotic drive and sex chromosome evolution, both of which have implications for fertility. ..
  35. An HPV Health Communication Randomized Controlled Trial Intervention
    SHERRIE LEE WALLINGTON; Fiscal Year: 2013
    ..H3: Daughters of mothers receiving the group educational intervention will have a higher rate of vaccine uptake than daughters of mothers in the control group.] ..
  36. Analysis of B cell transcriptome shifts prior to lineage divergence in vivo
    Ann M Haberman; Fiscal Year: 2013
    ....
  37. The Biochemical Basis for the Mechanics of Cytokinesis
    Douglas N Robinson; Fiscal Year: 2012
    ..In Aim 3, we will expand our molecular inquiry by identifying the affected genes in the REMI mutants we have already recovered. ..
  38. Analysis of Cell Death Regulation in C. elegans
    Barbara Conradt; Fiscal Year: 2012
    ..Therefore, the proposed studies will contribute to our basic understanding of developmental health disorders and are specifically relevant to understanding the behavior of cancer stem cells and, hence, tumorigenesis. ..
  39. DEVELOPMENT AND TESTING OF A JAMAICAN MOTHER-DAUGHTER HIV RISK-REDUCTION PROGRAM
    M Katherine Hutchinson; Fiscal Year: 2010
    ..Findings from this study will contribute to the development of effective HIV risk-reduction programs for Jamaican adolescent girls and young women. ..
  40. A Comparative History of Twentieth-Century Catholic Hospitals
    Barbra Mann Wall; Fiscal Year: 2010
    ..It will provide a complex illustration of what it means for institutions to encounter drastic change and emerge with a new vision and community purpose. ..
  41. Child Gender and Parental Investments: Are Boys and Girls Treated Differently
    Adriana Lleras-Muney; Fiscal Year: 2012
    ..We will also examine gender differences in other measures of child investments, such as vaccinations, vitamin A intake and breastfeeding. ..
  42. Breast Cancer Risk: Analysis of heightened HPA axis stress responsivity
    Dana H Bovbjerg; Fiscal Year: 2012
    ....
  43. Mothers and Girls DaNcing togETher Trial (Magnet Trial)
    Sofiya Alhassan; Fiscal Year: 2013
    ..We hope this approach presents a viable route to sustained physical activity for both mothers and daughters, thereby reducing obesity and diabetes. ..
  44. Communication about sex in the nuclear family and beyond: Implications for health
    Jennifer Grossman; Fiscal Year: 2013
    ..address changing teen-parent relationships over the transition to high school and demographic shifts away from nuclear family structure, we will longitudinally investigate continuity and change in teen-parent sexual communication and ..
  45. Family Therapy Development for Incarcerated Mothers with Substance Use Disorders
    MALITTA V ENGSTROM; Fiscal Year: 2010
    ....
  46. Cell Polarity in Self-renewal and Differentiation of Stem/Progenitor Cells
    Valeri Vasioukhin; Fiscal Year: 2012
    ..Knowledge obtained during this study will help to develop new therapies for treatment of tissue injury, degenerative diseases and cancer. ..
  47. HPV Vaccination in the Cambodian Community
    Victoria M Taylor; Fiscal Year: 2012
    ..A community-based telephone survey of 200 Cambodian mothers will be conducted, and a sub-sample of 50 survey participants will be asked to complete a retest survey. ..
  48. Cytoskeleton scaffold assembly in Toxoplasma gondii
    Marc Jan Gubbels; Fiscal Year: 2012
    ....
  49. ASYMMETRIC CELL DIVISION IN C. ELEGANS EMBRYOS
    Kenneth J Kemphues; Fiscal Year: 2013
    ..3) Using carbon nano-pipettes to develop a microinjection system and using that system to introduce compounds and proteins at specific times and locations in the early embryo to understand the initial events in polarity establishment. ..
  50. Stem Cells of the Developing Human Neocortex
    Arnold Kriegstein; Fiscal Year: 2013
    ....
  51. STUDIES ON MICROTUBULE BINDING PROTEINS
    Ronald A Milligan; Fiscal Year: 2013
    ..The structural results we obtain will provide the basis for a mechanistic understanding of some of the most important events taking place on spindle microtubules during cell division. ..
  52. Behavioral Activation/Armodafinil to Treat Fatigue in HIV/AIDS
    Milton L Wainberg; Fiscal Year: 2012
    ....
  53. Promoting cancer screening for mothers using a daughter-initiated approach
    Maghboeba Mosavel; Fiscal Year: 2012
    ..Finally, the findings from the proposed research will lead to subsequent R21 and R01 community-based cancer intervention research. ..
  54. Risk for Depression:Identifying and Altering Psychobiological Mechanisms
    Ian H Gotlib; Fiscal Year: 2013
    ..Understanding these mechanisms will help us to develop more effective approaches to the prevention of clinical depression. ..
  55. The maintenance of Drosophila testis stem cells during starvation
    HEIKO HUI YANG; Fiscal Year: 2013
    ..While this reaffirms the importance of protecting stem cells in a tissue, it challenges the belief that the tissue adaptation to stress is accomplished primarily through changes at the stem cell level. ..
  56. Formative Research on Substance Use & Disclosure for GLB Youth & their Families
    Erika L Grafsky; Fiscal Year: 2010
    ..Researchers have demonstrated that disclosing to family, particularly nuclear family members, may serve as a protective factor against reduced social support, mental health risks, and substance ..
  57. CONTROL OF STEM CELL FATE IN DROSOPHILA SPERMATOGENESIS
    ERIKA L MATUNIS; Fiscal Year: 2013
    ..Understanding how stem cells respond to niche signals is of fundamental importance for developing successful strategies to manipulate these potent cells in regenerative medicine. ..
  58. Latina Mothers'Coping Processes While Their Young Adult Sons Are Incarcerated
    TEODOCIA MARIA HAYES-BAUTISTA; Fiscal Year: 2012
    ..abstract_text> ..
  59. Faith-Based HIV Prevention Intervention for African American Mothers &Daughters
    Chisina Tsvakayi Kapungu; Fiscal Year: 2013
    ....
  60. Family Education to Reduce Teen Drinking and Promote Safe Driving
    LYDIA N O apos DONNELL; Fiscal Year: 2010
    ....
  61. Decision-Making about Childhood HPV Vaccination among Low SES Mothers
    TIFFANY FLOYD; Fiscal Year: 2009
    ..Results from this research will be used to inform decision-making interventions for mothers from low SES backgrounds, many of whom may face unique barriers to vaccinating their daughters against HPV. ..
  62. Implementing Newborn Screening for Duchenne Muscular Dystrophy in the Community
    Jerry Mendell; Fiscal Year: 2009
    ..This proposal will establish a statewide program in Ohio for newborn screening for DMD that can be used as a template to expand this to a national voluntary screening program. ..
  63. THE BIODEMOGRAPHY OF HUMAN LONGEVITY--A TRAINING PROGRAM
    Leonid Gavrilov; Fiscal Year: 2005
    ..The award allows the investigator not only to complete the proposed training and research projects, but also to develop a full-scale long-term research program in the biodemography of human longevity. ..
  64. RADON, BRONCHIAL MORPHOMETRY, AND OCCUPATIONAL HEALTH
    David Brenner; Fiscal Year: 1993
    ....
  65. A Forty-Year Followup of Men at High Risk for Alcoholism
    ELIZABETH PENICK; Fiscal Year: 2004
    ..Marc Schuckit, MD, a researcher experienced in conducting high-risk, longitudinal studies of alcoholism, will serve as our major consultant. ..
  66. PHYSICAL MAP OF RP2 AND RP3 LOCI ON HUMAN X-CHROMOSOME
    BRATIN SAHA; Fiscal Year: 1990
    ..These physical mapping data will then be utilized to construct new probes for the diagnosis and eventual cloning of the XLRP gene(s)...
  67. GENETIC MECHANISMS OF ALCOHOLIC ORGANIC BRAIN DISEASE
    Peter Martin; Fiscal Year: 1992
    ..The identified patients would serve as probands for future pedigree studies to evaluate the association between transketolase genotype and alcoholic organic brain disease and to determine the mode of inheritance of transketolase...
  68. Distress Tolerance: Links with Family Emotional Climate and Adolescent HIV Risk
    Jude Cassidy; Fiscal Year: 2009
    ..Because these data will contribute to the development of a more comprehensive model of vulnerability to HIV risk behavior, they will in turn be useful in creating effective intervention programs. ..
  69. Sex Ratios and Family Life in China
    SCOTT SOUTH; Fiscal Year: 2009
    ..Therefore, learning more about the family-related impacts of China's male surplus and female deficit is an important scientific objective. ..
  70. Functional genomics of molluscan schistosome development
    TIMOTHY YOSHINO; Fiscal Year: 2009
    ..Results of this work may lead to novel strategies for controlling infections within the snail host by disrupting specific larval development-dependent genes or their products. ..
  71. MECHANISMS GENERATING TEMPORAL EMBRYONIC GENE EXPRESSION
    Geoffrey Childs; Fiscal Year: 1999
    ..These studies pertain directly to understanding the precise and detailed mechanisms underlying differential gene expression during embryogenesis and differentiation. ..
  72. Molecular Evolution of X-Y Meiotic Drive in Drosophila
    Andrew Clark; Fiscal Year: 2004
    ..An analogous reasoning applies to the XSR chromosomes. DNA sequences will also be used to estimate the age of these selfish genes, using analytical methods based on the molecular clock. ..