maternal behavior

Summary

Summary: The behavior patterns associated with or characteristic of a mother.

Top Publications

  1. ncbi Like mother, like daughter: evidence for non-genomic transmission of parental behavior and stress responsivity
    F Champagne
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry, and Neurology and Neurosurgery, McGill University, Montreal, PQ H4H 1R3, Canada
    Prog Brain Res 133:287-302. 2001
  2. ncbi Maternal postpartum behavior and the emergence of infant-mother and infant-father synchrony in preterm and full-term infants: the role of neonatal vagal tone
    Ruth Feldman
    Department of Psychology and the Gonda Brain Sciences Center, Bar Ilan University, Ramat Gan, Israel, 52900
    Dev Psychobiol 49:290-302. 2007
  3. ncbi Epigenetic programming by maternal behavior
    Ian C G Weaver
    Douglas Hospital Research Center, 6875 LaSalle Blvd, Montreal, Quebec H4H 1R3, Canada
    Nat Neurosci 7:847-54. 2004
  4. ncbi Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
    M J Meaney
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, Department of Psychiatry and McGill Centre for the Study of Behavior, Genes and Environment, McGill University, Montreal, Canada
    Annu Rev Neurosci 24:1161-92. 2001
  5. pmc Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
    Ian C G Weaver
    Douglas Hospital Research Center, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 103:3480-5. 2006
  6. ncbi Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life
    Ian C G Weaver
    Douglas Hospital Research Center, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 25:11045-54. 2005
  7. ncbi Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
    Danielle L Champagne
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 28:6037-45. 2008
  8. pmc Dose-dependent effects of multiple acute cocaine injections on maternal behavior and aggression in Sprague-Dawley rats
    J M Johns
    Department of Psychiatry, University of North Carolina, Chapel Hill, N C 27599 7096, USA
    Dev Neurosci 20:525-32. 1998
  9. ncbi Gestational stress induces post-partum depression-like behaviour and alters maternal care in rats
    J W Smith
    Neuropharmacology Research Group, Department of Pharmacology, School of Pharmacy, University of Bradford, Bradford BD7 1DP, UK
    Psychoneuroendocrinology 29:227-44. 2004
  10. ncbi Variations in maternal care alter GABA(A) receptor subunit expression in brain regions associated with fear
    Christian Caldji
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, Montreal, Canada H4H 1R3
    Neuropsychopharmacology 28:1950-9. 2003

Detail Information

Publications378 found, 100 shown here

  1. ncbi Like mother, like daughter: evidence for non-genomic transmission of parental behavior and stress responsivity
    F Champagne
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry, and Neurology and Neurosurgery, McGill University, Montreal, PQ H4H 1R3, Canada
    Prog Brain Res 133:287-302. 2001
    ..Such intergenerational transmission of maternal behavior is seen in rodents, primates and humans, and may underlie adaptive changes in the HPA axis...
  2. ncbi Maternal postpartum behavior and the emergence of infant-mother and infant-father synchrony in preterm and full-term infants: the role of neonatal vagal tone
    Ruth Feldman
    Department of Psychology and the Gonda Brain Sciences Center, Bar Ilan University, Ramat Gan, Israel, 52900
    Dev Psychobiol 49:290-302. 2007
    ..b>Maternal behavior, mother depressive symptoms, and infant cardiac vagal tone were assessed in the neonatal period...
  3. ncbi Epigenetic programming by maternal behavior
    Ian C G Weaver
    Douglas Hospital Research Center, 6875 LaSalle Blvd, Montreal, Quebec H4H 1R3, Canada
    Nat Neurosci 7:847-54. 2004
    ..Thus we show that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible...
  4. ncbi Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
    M J Meaney
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, Department of Psychiatry and McGill Centre for the Study of Behavior, Genes and Environment, McGill University, Montreal, Canada
    Annu Rev Neurosci 24:1161-92. 2001
    ..Maternal care also influences the maternal behavior of female offspring, an effect that appears to be related to oxytocin receptor gene expression, and which ..
  5. pmc Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
    Ian C G Weaver
    Douglas Hospital Research Center, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 103:3480-5. 2006
    ..These results suggest that early-life experience has a stable and broad effect on the hippocampal transcriptome and anxiety-mediated behavior, which is potentially reversible in adulthood...
  6. ncbi Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life
    Ian C G Weaver
    Douglas Hospital Research Center, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 25:11045-54. 2005
    ..Here we report that methionine infusion reverses the effect of maternal behavior on DNA methylation, nerve growth factor-inducible protein-A binding to the exon 1(7) promoter, GR expression,..
  7. ncbi Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
    Danielle L Champagne
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 28:6037-45. 2008
    ....
  8. pmc Dose-dependent effects of multiple acute cocaine injections on maternal behavior and aggression in Sprague-Dawley rats
    J M Johns
    Department of Psychiatry, University of North Carolina, Chapel Hill, N C 27599 7096, USA
    Dev Neurosci 20:525-32. 1998
    ..Dams were observed 30 min following injections for maternal behavior (MB) towards 8 surrogate male pups on PPD 1 and PPD 3 and for aggression towards a male or female intruder ..
  9. ncbi Gestational stress induces post-partum depression-like behaviour and alters maternal care in rats
    J W Smith
    Neuropharmacology Research Group, Department of Pharmacology, School of Pharmacy, University of Bradford, Bradford BD7 1DP, UK
    Psychoneuroendocrinology 29:227-44. 2004
    ..GS may be an important factor in maternal post-natal depression, which may in turn detrimentally effect the offspring because depressed mothers do not sufficiently care for their offspring...
  10. ncbi Variations in maternal care alter GABA(A) receptor subunit expression in brain regions associated with fear
    Christian Caldji
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, Montreal, Canada H4H 1R3
    Neuropsychopharmacology 28:1950-9. 2003
    ....
  11. pmc Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome
    Michael J Meaney
    McGill Program for the Study of Behavior, Genes and Environment, Department of Pharmacology, McGill University, Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Dialogues Clin Neurosci 7:103-23. 2005
    ....
  12. ncbi Epigenetics and the biological definition of gene x environment interactions
    Michael J Meaney
    McGill University, Montreal, QC, Canada
    Child Dev 81:41-79. 2010
    ....
  13. ncbi Epigenetic programming of stress responses through variations in maternal care
    Eric W Fish
    McGill Program for the Study of Behavior, Genes and Environment, Douglas Hospital Research Centre, McGill University, Montreal, Canada
    Ann N Y Acad Sci 1036:167-80. 2004
    ..Given the importance of early life and parent-child interactions to later behavior, prevention and intervention programs should target this critical phase of development...
  14. ncbi Sex differences in the parental behavior of rodents
    J S Lonstein
    Center for Neuroendocrine Studies, Tobin Hall, University of Massachusetts, Amherst, MA 01003, USA
    Neurosci Biobehav Rev 24:669-86. 2000
    ..Understanding the mechanisms that generate sex differences in the parental responsiveness of rodents may indicate how similar sex differences in parental care are generated in other mammals...
  15. ncbi Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model
    Frances A Champagne
    McGill Program for the Study of Behavior, Genes and Environment and Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, Montreal, Canada
    Biol Psychiatry 59:1227-35. 2006
    ..We addressed the question of whether stressors can directly affect parental behavior using a rodent model of stable, individual differences in maternal behavior.
  16. ncbi Acute cocaine alters oxytocin levels in the medial preoptic area and amygdala in lactating rat dams: implications for cocaine-induced changes in maternal behavior and maternal aggression
    J C Elliott
    Department of Psychology, University of North Carolina at Chapel Hill, NC 27599 3270, USA
    Neuropeptides 35:127-34. 2001
    Acute cocaine administration has been correlated with disruptions in the onset and maintenance of maternal behavior as well as decreases in maternal aggressive behavior in rat dams...
  17. pmc Oxytocin-dopamine interactions mediate variations in maternal behavior in the rat
    Dara K Shahrokh
    Sackler Program for Epigenetics and Psychobiology at McGill University, Douglas Mental Health University Institute, McGill University, Montreal, Canada
    Endocrinology 151:2276-86. 2010
    Variations in maternal behavior among lactating rats associate with differences in estrogen-oxytocin interactions in the medial preoptic area (mPOA) and in dopamine levels in the nucleus accumbens (nAcc)...
  18. pmc The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genes
    Ian C G Weaver
    Douglas Hospital Research Center, Montreal, Quebec, Canada H4H 1R3
    J Neurosci 27:1756-68. 2007
    ..The data are consistent with the hypothesis that NGFI-A participates in epigenetic programming of GR expression...
  19. ncbi Variations in maternal care in the rat as a mediating influence for the effects of environment on development
    Frances A Champagne
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
    Physiol Behav 79:359-71. 2003
    ..In the rat, variations in maternal behavior, particularly in licking/grooming, regulate the development of endocrine, emotional and cognitive responses ..
  20. ncbi Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: let's call the whole thing off
    Ian C G Weaver
    The Hospital for Sick Children, Department of Developmental Biology, Toronto, Ontario, Canada
    Epigenetics 2:22-8. 2007
    ..Similarly, maternal behavior in rodents is associated with long-term programming of individual differences in behavioral and hypothalamic-..
  21. pmc Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors
    F Champagne
    Developmental Neuroendocrinology Laboratory and McGill Program for the Study of Behavior, Genes, and Environment, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 98:12736-41. 2001
    ..We found that the induction of maternal behavior in virgin females through constant exposure to pups (pup sensitization) was significantly shorter in the ..
  22. pmc Cocaine treatment and prenatal environment interact to disrupt intergenerational maternal behavior in rats
    Josephine M Johns
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Behav Neurosci 119:1605-18. 2005
    The link between impaired maternal behavior (MB) and cocaine treatment could result from drug-induced decreases in maternal reactivity to offspring, prenatal drug exposure (PDE) in offspring that could alter their ability to elicit MB, ..
  23. ncbi Functional, anatomical, and neurochemical differentiation of medial preoptic area subregions in relation to maternal behavior in the mouse
    Yousuke Tsuneoka
    Research Unit for Affiliative Social Behavior, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Comp Neurol 521:1633-63. 2013
    ..previous findings indicate critical involvement of the medial preoptic area (MPOA) in the neural control of maternal behavior. However, the specification of the particular MPOA subregions involved in maternal behavior and the ..
  24. pmc Hypocretin-1 dose-dependently modulates maternal behaviour in mice
    K L D'Anna
    Department of Zoology, University of Wisconsin, Madison, WI, USA
    J Neuroendocrinol 18:553-66. 2006
    ..06 and 0.1 microg) supporting (even augmenting) some behaviours, but with levels that are too high (0.3 microg HCRT, i.c.v.), maternal behaviour and aggression are suppressed...
  25. ncbi Post-hatching parental care masks the effects of egg size on offspring fitness: a removal experiment on burying beetles
    K M Monteith
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    J Evol Biol 25:1815-22. 2012
    ..These findings suggest that the trade-off between number and size of offspring is shifted from the egg stage towards the end of the parental care period and that post-hatching parental care somehow moderates this trade-off...
  26. pmc Effects of maternal behavior induction and pup exposure on neurogenesis in adult, virgin female rats
    Miyako Furuta
    Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, United States
    Brain Res Bull 80:408-13. 2009
    ..In the present study, the effects of maternal behavior induction and pup exposure on neurogenesis in nulliparous rats were examined in order to determine whether ..
  27. ncbi Corticotropin-releasing factor inhibits maternal aggression in mice
    Stephen C Gammie
    Neuroscience Training Program, Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
    Behav Neurosci 118:805-14. 2004
    ..These findings suggest that decreased CRF is necessary for maternal aggression and may act by altering brain activity in response to an intruder...
  28. ncbi Annual Research Review: All mothers are not created equal: neural and psychobiological perspectives on mothering and the importance of individual differences
    Jennifer Barrett
    Department of Psychology, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    J Child Psychol Psychiatry 52:368-97. 2011
    ..to the mothering experience: (a) social behavior; (b) reward and affect; (c) executive function; and (d) maternal behavior. We find that there are many commonalities in terms of the brain regions identified across these systems and,..
  29. ncbi Neuromolecular basis of parental behavior in laboratory mice and rats: with special emphasis on technical issues of using mouse genetics
    Kumi O Kuroda
    Unit for Affiliative Social Behavior, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1205-31. 2011
    ..Basic protocols and technical considerations on studying the mechanism of parental behavior using genetically-engineered mouse strains will also be presented...
  30. pmc Gene array profiling of large hypothalamic CNS regions in lactating and randomly cycling virgin mice
    Stephen C Gammie
    Department of Zoology, University of Wisconsin, 1117 W Johnson Street, Madison, WI 53706, USA
    Brain Res Mol Brain Res 139:201-11. 2005
    ..Together, our findings provide possible new material on gene expression changes that may support maternal behaviors. The advantages and drawbacks of sampling large CNS regions using arrays are discussed...
  31. ncbi Adult hippocampal glucocorticoid receptor expression and dentate synaptic plasticity correlate with maternal care received by individuals early in life
    Felisa N van Hasselt
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Hippocampus 22:255-66. 2012
    ..We conclude that even moderate variations in early life environment have a major impact on adult hippocampal function. This principle could provide a mechanistic basis for individual differences in susceptibility to psychopathology...
  32. pmc Frequency of infant stroking reported by mothers moderates the effect of prenatal depression on infant behavioural and physiological outcomes
    Helen Sharp
    Institute of Psychology, Health and Society, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 7:e45446. 2012
    ....
  33. ncbi Stress inoculation-induced indications of resilience in monkeys
    David M Lyons
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305 5485, USA
    J Trauma Stress 20:423-33. 2007
    ....
  34. ncbi Paternal care in rodents: weakening support for hormonal regulation of the transition to behavioral fatherhood in rodent animal models of biparental care
    Katherine E Wynne-Edwards
    Department of Biology, Queen s University, Kingston, ON, Canada K7L 3N6
    Horm Behav 52:114-21. 2007
    ..Paternal males might nevertheless use the same hormones to activate pre-existing maternal behavior pathways in the brain...
  35. ncbi Parenting behavior is associated with the early neurobehavioral development of very preterm children
    Karli Treyvaud
    Critical Care and Neurosciences, Murdoch Childrens Research Institute, Victoria, Australia
    Pediatrics 123:555-61. 2009
    ..The aim of this study was to assess the relationship between parenting behavior, parent-child synchrony, and neurobehavioral development in very preterm children at 24 months of age...
  36. pmc Perceived early-life maternal care and the cortisol response to repeated psychosocial stress
    Veronika Engert
    Department of Psychiatry, Douglas Mental Health University Institute, Montreal, QC
    J Psychiatry Neurosci 35:370-7. 2010
    ..In our own previous studies, we have shown how variations in early-life parental care influence the development of the hippocampus and modify the cortisol awakening response...
  37. ncbi Prenatal paracetamol exposure and asthma: further evidence against confounding
    Seif O Shaheen
    Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK
    Int J Epidemiol 39:790-4. 2010
    ....
  38. ncbi Prenatal stress and long-term consequences: implications of glucocorticoid hormones
    S Maccari
    Laboratory Perinatal Stress, Universite de Lille 1, Bat SN4 1, 59655 Villeneuve d Ascq cedex, France
    Neurosci Biobehav Rev 27:119-27. 2003
    ..Some biological abnormalities in depression can be related to those found in PNRS rats reinforcing the idea of the usefulness of PNRS rats as an appropriate animal model to study new pharmacological approaches...
  39. ncbi Does maternal prenatal attachment predict postnatal mother-infant interaction?
    A Siddiqui
    Department of Clinical Sciences, Division of Child and Adolescent Psychiatry, Umea University, S 901 85, Umea, Sweden
    Early Hum Dev 59:13-25. 2000
    ....
  40. ncbi Variations in the postnatal maternal environment in mice: effects on maternal behaviour and behavioural and endocrine responses in the adult offspring
    Laurence Coutellier
    Division of Animal Welfare and Ethology, Institute of Veterinary Physiology, University of Giessen, Frankfurter Strasse 104, D 35392 Giessen, Germany
    Physiol Behav 93:395-407. 2008
    ....
  41. ncbi Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review
    Bea R H Van den Bergh
    Department of Developmental Psychology, Catholic University of Leuven KULeuven, Tiensestraat 102, 3000 Leuven, Belgium
    Neurosci Biobehav Rev 29:237-58. 2005
    ..The magnitude of the long-term effects of antenatal maternal anxiety/stress on the child is substantial. Programs to reduce maternal stress in pregnancy are therefore warranted...
  42. ncbi Natural variations in postpartum maternal care in inbred and outbred mice
    Frances A Champagne
    Sub Department of Animal Behaviour, University of Cambridge, High Street, Madingley, CB3 8AA Cambridge United Kingdom
    Physiol Behav 91:325-34. 2007
    ..These results illustrate that through detailed analysis of maternal behavior in mice, variations between strains can be observed...
  43. pmc Cocaine disrupts pup-induced maternal behavior in juvenile and adult rats
    Josephine M Johns
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7096, USA
    Neurotoxicol Teratol 29:634-41. 2007
    Impaired onset of maternal behavior in first generation rat dams was previously correlated with rearing by cocaine-treated dams and prenatal cocaine exposure...
  44. ncbi Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam
    Susanne Brummelte
    Department of Psychology and Brain Research Center, University of British Columbia, Vancouver, BC, Canada
    Horm Behav 58:769-79. 2010
    ..More research is needed to understand the effects of stress hormones during different phases of reproduction and how they affect the brain and behavior of the mother and her offspring...
  45. ncbi Effects of short- and long-term withdrawal from gestational cocaine treatment on maternal behavior and aggression in Sprague-Dawley rats
    J M Johns
    Department of Psychiatry, University of North Carolina, Chapel Hill 27599 7096, USA
    Dev Neurosci 19:368-74. 1997
    ..All cocaine-treated dams exhibited more disruptions in the onset of maternal behavior (retrieval, licking, crouching) and were more aggressive (threats and attacks) towards an intruder on ..
  46. ncbi Maternal behavior of primiparous females in inbred strains of mice: a detailed descriptive analysis
    Hirotaka Shoji
    Institute of Psychology, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8572, Japan
    Physiol Behav 89:320-8. 2006
    ..The present results revealed strain-specific variations in maternal behavior. In general, BALB did not engage in maternal behavior very vigorously, but the other four strains actively ..
  47. ncbi Maternal influences on adult stress and anxiety-like behavior in C57BL/6J and BALB/cJ mice: a cross-fostering study
    Kristianne Priebe
    Department of Psychology, University of California Santa Barbara, 93106 9660, USA
    Dev Psychobiol 47:398-407. 2005
    ..Cross-fostering did alter anxiety-like behavior and basal corticosterone levels, which suggests that while genetic differences account for some of the variations between these two strains early rearing conditions also contribute...
  48. ncbi A dose-response study of chronic cocaine on maternal behavior in rats
    C J Nelson
    Department of Psychology, School of Medicine, University of North Carolina at Chapel Hill, 27599 3270, USA
    Neurotoxicol Teratol 20:657-60. 1998
    To determine if there was a dose-response relationship with regard to cocaine treatment and maternal behavior exhibited by lactating rats at doses that had not been previously investigated, we examined the effects of three doses of ..
  49. ncbi Variations of maternal care alter offspring levels of behavioural defensiveness in adulthood: evidence for a threshold model
    J L Menard
    Department of Psychology, Queen s University, Humphrey Hall, 62 Arch St, Kingston, Ont, Canada K7L 3N6
    Behav Brain Res 176:302-13. 2007
    ....
  50. ncbi The mouse communal nest: investigating the epigenetic influences of the early social environment on brain and behavior development
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Roma, Italy
    Neurosci Biobehav Rev 33:551-9. 2009
    ..Overall, CN appears as an experimental strategy different and complementary to the ones currently used for studying how the early environment determines developmental trajectories...
  51. ncbi Direct and indirect effects of breast milk on the neurobehavioral and cognitive development of premature infants
    Ruth Feldman
    Department of Psychology, Bar Ilan University, Ramat Gan, Israel, 52900
    Dev Psychobiol 43:109-19. 2003
    ..In addition to its nutritional value, breast milk may be related to improved maternal mood and interactive behaviors, thereby indirectly contributing to development in premature infants...
  52. ncbi Maternal care, the epigenome and phenotypic differences in behavior
    Moshe Szyf
    Department of Pharmacology and Therapeutics, McGill University, 3655 Sir William Osler Promenade, Montreal, Quebec H3G 1Y6, Canada
    Reprod Toxicol 24:9-19. 2007
    ..We will propose here a mechanism linking maternal behavior and epigenetic programming and we will discuss the prospect that similar epigenetic variations generated ..
  53. ncbi A potential role for thalamocingulate circuitry in human maternal behavior
    Jeffrey P Lorberbaum
    Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 51:431-45. 2002
    Little is known about the regional brain basis of human maternal behavior. To understand this better, we have been examining brain activity in mothers listening to infant cries.
  54. ncbi Medial preoptic area interactions with dopamine neural systems in the control of the onset and maintenance of maternal behavior in rats
    Michael Numan
    Department of Psychology, Boston College, McGuinn Hall, Chestnut Hill, MA 02467, USA
    Front Neuroendocrinol 30:46-64. 2009
    The medial preoptic area (MPOA) and dopamine (DA) neural systems interact to regulate maternal behavior in rats. Two DA systems are involved: the mesolimbic DA system and the incerto-hypothalamic DA system...
  55. ncbi Maternal care and the development of stress responses
    D D Francis
    Developmental Neuroendocrinology Laboratory Douglas Hospital Research Center Departments of Psychiatry and Neurology and Neurosurgery 6875 Boul LaSalle McGill University Montréal Canada H4H 1R3
    Curr Opin Neurobiol 9:128-34. 1999
    ....
  56. ncbi Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent-infant contact
    Ruth Feldman
    Department of Psychology, Bar Ilan University, Ramat Gan, Israel
    Psychoneuroendocrinology 35:1133-41. 2010
    ....
  57. pmc Maternal stress and high-fat diet effect on maternal behavior, milk composition, and pup ingestive behavior
    Ryan H Purcell
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Physiol Behav 104:474-9. 2011
    ..In the present studies, we examined maternal behavior and milk composition as well as offspring ingestive behavior...
  58. ncbi Roles of estrogen receptor-alpha gene expression in reproduction-related behaviors in female mice
    S Ogawa
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, New York 10021, USA
    Endocrinology 139:5070-81. 1998
    ..In addition, persistence of genotype differences in parental and aggressive behavior after gonadectomy indicates that ER alpha activation during neural developmental processes may also be involved in the regulation of these behaviors...
  59. ncbi Maternal psychological distress and parenting stress after the birth of a very low-birth-weight infant
    L T Singer
    Department of Pediatrics, School of Medicine, Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio, USA
    JAMA 281:799-805. 1999
    ..Few studies document how parents adapt to the experience of a very low-birth-weight (VLBW; <1500 g) birth despite societal concerns about the ethics and justification of intensive care for these infants...
  60. pmc Maternal smoking and child psychological problems: disentangling causal and noncausal effects
    Marie Jo Brion
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK
    Pediatrics 126:e57-65. 2010
    ..To explore associations of maternal prenatal smoking and child psychological problems and determine the role of causal intrauterine mechanisms...
  61. ncbi Palatable cafeteria diet ameliorates anxiety and depression-like symptoms following an adverse early environment
    Jayanthi Maniam
    School of Medical Sciences, University of New South Wales, NSW 2052, Australia
    Psychoneuroendocrinology 35:717-28. 2010
    ..These results highlight the important place of palatable food in reducing central stress responses supporting the therapeutic value of 'comfort food'...
  62. pmc Dynamics of early childhood overweight
    Pamela J Salsberry
    College of Nursing, School of Public Health, Ohio State University, Columbus, OH, USA
    Pediatrics 116:1329-38. 2005
    ....
  63. ncbi Maternal behavior predicts infant cortisol recovery from a mild everyday stressor
    Esther M Albers
    Department of Developmental Psychology, Behavioural Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands
    J Child Psychol Psychiatry 49:97-103. 2008
    ..to a mild everyday stressor, namely being taken out of the bath, were examined in relation to the quality of maternal behavior. It was hypothesized that a higher quality of maternal behavior towards the infant predicted lower cortisol ..
  64. ncbi Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride
    Jens C Pruessner
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    J Neurosci 24:2825-31. 2004
    ..These data suggest that aversive stressful events can be associated with mesolimbic dopamine release in humans, and that the method presented here may be useful to study the effects of early life events on neurobiological stress systems...
  65. ncbi Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years. Report from the Avon Longitudinal Study of Parents and Children
    Thomas G O'Connor
    Institute of Psychiatry, Denmark Hill, London
    Br J Psychiatry 180:502-8. 2002
    ..Animal experiments suggest that maternal stress and anxiety during pregnancy have long-term effects on the behaviour of the offspring...
  66. ncbi Identifying molecular substrates in a mouse model of the serotonin transporter x environment risk factor for anxiety and depression
    Valeria Carola
    Mouse Biology Unit, European Molecular Biology Laboratory, Monterotondo, Rome, Italy
    Biol Psychiatry 63:840-6. 2008
    ..Such an understanding might help to identify novel targets for the diagnosis and therapy of mood disorders. To address this need, we developed a gene-environment screening paradigm in the mouse...
  67. pmc Dysfunctional nurturing behavior in rat dams with limited access to nesting material: a clinically relevant model for early-life stress
    A S Ivy
    Department of Anatomy Neurobiology, University of California at Irvine, Irvine, CA 92697 4475, USA
    Neuroscience 154:1132-42. 2008
    ....
  68. pmc Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting
    Marian J Bakermans-Kranenburg
    Centre for Child and Family Studies, Leiden University, PO Box 9555, NL 2300 RB Leiden, The Netherlands
    Soc Cogn Affect Neurosci 3:128-34. 2008
    ..This first study on the role of both OXTR and 5-HTT genes in human parenting points to molecular genetic differences that may be implicated in the production of oxytocin explaining differences in sensitive parenting...
  69. ncbi The effects of D1 or D2 dopamine receptor antagonism in the medial preoptic area, ventral pallidum, or nucleus accumbens on the maternal retrieval response and other aspects of maternal behavior in rats
    Michael Numan
    Department of Psychology, Boston College, Boston, Chestnut Hill, MA 02467, USA
    Behav Neurosci 119:1588-604. 2005
    ..MPOA), ventral pallidum (VP), and nucleus accumbens (NA) receive dopaminergic afferents and are involved in maternal behavior. Experiments investigated whether dopamine (DA) receptor antagonism in NA disrupts maternal behavior, ..
  70. ncbi The role of oxytocin in mother-infant relations: a systematic review of human studies
    Megan Galbally
    Mercy Hospital for Women, Melbourne, Australia
    Harv Rev Psychiatry 19:1-14. 2011
    Oxytocin is associated with the establishment and quality of maternal behavior in animal models. Parallel investigations in humans are now under way...
  71. pmc Mother-infant interactions in free-ranging rhesus macaques: relationships between physiological and behavioral variables
    Dario Maestripieri
    Department of Comparative Human Development, University of Chicago, 5730 S Woodlawn Avenue, Chicago, IL 60637 USA
    Physiol Behav 96:613-9. 2009
    ..examine the extent to which interindividual variation in maternal physiology is associated with variation in maternal behavior; 3) examine the extent to which interindividual variation in infant physiology and behavior is accounted for ..
  72. ncbi Gene-environment interaction of the dopamine D4 receptor (DRD4) and observed maternal insensitivity predicting externalizing behavior in preschoolers
    Marian J Bakermans-Kranenburg
    Center for Child and Family Studies, Leiden University, The Netherlands
    Dev Psychobiol 48:406-9. 2006
    ..The data indicate that children are differentially susceptible to insensitive parenting dependent on the presence of the 7-repeat DRD4 allele...
  73. ncbi Olfactory regulation of maternal behavior in mammals
    F Levy
    Equipe Comportement, Station PRC, UMR 6175 INRA CNRS Universite de Tours Haras Nationaux, 37380, Nouzilly, France
    Horm Behav 46:284-302. 2004
    ..Perception of the smell of the young also regulates various aspects of maternal behavior. Dodecyl propionate, a compound released by of pup's preputial glands, has been shown to influence ..
  74. ncbi Associations between maternal feeding style and food intake of children with a higher risk for overweight
    Katja Kröller
    University of Potsdam, Institute of Psychology, Karl Liebknecht Str 24 25, 14476 Potsdam OT Golm, Germany
    Appetite 51:166-72. 2008
    ..The aim of this study is to examine the impact of different feeding strategies on the child's food intake as well as the effect and influence socio-economic status and weight have on the use of feeding strategies...
  75. ncbi Natural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic area
    Frances A Champagne
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boulevard, Montreal, Canada H4H 1R3
    Endocrinology 144:4720-4. 2003
    ..Such naturally occurring variations in maternal behavior are associated with differences in estrogen-inducible oxytocin receptors in the medial preoptic area (MPOA) ..
  76. ncbi Early disruption of the mother-infant relationship: effects on brain plasticity and implications for psychopathology
    F Cirulli
    Behavioural Pathophysiology Section, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Neurosci Biobehav Rev 27:73-82. 2003
    ..Changes in the levels of neurotrophic factors during critical developmental stages might result in long-term changes in neuronal plasticity and lead to increased vulnerability to aging and to psychopathology...
  77. ncbi Maternal touch and maternal child-directed speech: effects of depressed mood in the postnatal period
    Eisquel Herrera
    Department of Psychology, University of Aberdeen, William Guild Building, Scotland AB 24 2UB, UK
    J Affect Disord 81:29-39. 2004
    ..Postnatal depression affects the emotional state of mothers and the quality of mother-infant interaction...
  78. ncbi Randomized controlled trial to determine effects of prenatal breastfeeding workshop on maternal breastfeeding self-efficacy and breastfeeding duration
    Joy Noel-Weiss
    School of Nursing, University of Ottawa, Ontario, Canada
    J Obstet Gynecol Neonatal Nurs 35:616-24. 2006
    ..To determine the effects of a prenatal breastfeeding workshop on maternal breastfeeding self-efficacy and breastfeeding duration...
  79. ncbi Controlling feeding practices: cause or consequence of early child weight?
    Claire Victoria Farrow
    School of Psychology, Keele University, Keele, Staffordshire, United Kingdom
    Pediatrics 121:e164-9. 2008
    ..The aims of this study were to explore the direction of causality in these relationships during infancy...
  80. pmc Do state breastfeeding laws in the USA promote breast feeding?
    Summer Sherburne Hawkins
    Harvard School of Public Health, Harvard Center for Population and Development Studies, Harvard School of Public Health, Cambridge, MA 02138, USA
    J Epidemiol Community Health 67:250-6. 2013
    ..We examined the impact of state breastfeeding laws on breastfeeding initiation and duration as well as on disparities in these infant feeding practices...
  81. ncbi Maternal care influences hippocampal N-methyl-D-aspartate receptor function and dynamic regulation by corticosterone in adulthood
    Rosemary C Bagot
    Neuroscience Division, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Biol Psychiatry 72:491-8. 2012
    ..We hypothesized that altered NMDAR function underlies the interaction of maternal and stress effects on hippocampal synaptic plasticity...
  82. ncbi Heritability of parental effort in a passerine bird
    Andrew D C MacColl
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Evolution 57:2191-5. 2003
    ..Using both parent-offspring regression, and an animal model approach, with a pedigree derived from ringing data, we show that our measure of effort has a significant heritable component...
  83. ncbi Medial preoptic area interactions with the nucleus accumbens-ventral pallidum circuit and maternal behavior in rats
    Michael Numan
    Department of Psychology, Boston College, McGuinn Hall, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    Behav Brain Res 158:53-68. 2005
    ..roles of nucleus accumbens (NA), ventral pallidum (VP) and medial preoptic area (MPOA) in the regulation of maternal behavior in rats...
  84. ncbi GABA receptor agonists in the medial preoptic area and maternal behavior in lactating rats
    Porfirio Gómora Arrati
    Centro de Investigacion en Reproduccion Animal, CINVESTAV UAT, Apdo Postal 62, Tlax Tlaxcala 90000, Mexico
    Physiol Behav 87:51-65. 2006
    ..brain regions, the bed nucleus of the stria terminalis (BNST), and lateral preoptic area (LPO) on maternal behavior. Lactating female rats were implanted with bilateral cannulae in the MPOA/BNST on day 1 postpartum...
  85. ncbi Intergenerational transmission of maternal behavior in rhesus macaques and its underlying mechanisms
    Dario Maestripieri
    Department of Comparative Human Development The University of Chicago Chicago, IL 60637, USA
    Dev Psychobiol 49:165-71. 2007
    ..Their maternal behavior was compared to the behavior of both their foster and their biological mothers, and analyzed in relation to ..
  86. ncbi Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring
    Frances A Champagne
    Douglas Hospital Research Center, Montreal, Quebec, Canada H4H 1R3
    Endocrinology 147:2909-15. 2006
    Variations in maternal behavior are associated with differences in estrogen receptor (ER)-alpha expression in the medial preoptic area (MPOA) and are transmitted across generations such that, as adults, the female offspring of mothers ..
  87. ncbi A testosterone-mediated trade-off between parental and sexual effort in male mongolian gerbils (Meriones unguiculatus)
    M M Clark
    Department of Psychology, McMaster University, Hamilton, Ontario, Canada
    J Comp Psychol 113:388-95. 1999
    ..The findings are consistent with E. D. Ketterson and V. Nolan's (1994) hypothesis implicating T in mediating trade-offs between parental and sexual effort...
  88. ncbi Maternal behavior stimulates c-fos activity within estrogen receptor alpha-containing neurons in lactating rats
    J S Lonstein
    Center for Neuroendocrine Studies, University of Massachusetts, Amherst, Mass, 01003 7720, USA
    Neuroendocrinology 72:91-101. 2000
    Estradiol and other hormones are thought to be critical for the onset, but not maintenance, of maternal behavior in rats...
  89. ncbi Motivational systems and the neural circuitry of maternal behavior in the rat
    Michael Numan
    Department of Psychology, McGuinn Hall, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    Dev Psychobiol 49:12-21. 2007
    Jay Rosenblatt's approach-avoidance model of maternal behavior proposes that maternal behavior occurs when the tendency to approach infant stimuli is greater than the tendency to avoid such stimuli...
  90. ncbi Oxytocin receptors in the nucleus accumbens facilitate "spontaneous" maternal behavior in adult female prairie voles
    D E Olazabal
    Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    Neuroscience 141:559-68. 2006
    Oxytocin and the nucleus accumbens have been extensively implicated in the regulation of maternal behavior, and the processing of pup-related stimuli relevant for this behavior...
  91. pmc Enhanced maternal aggression and associated changes in neuropeptide gene expression in multiparous rats
    Benjamin C Nephew
    Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA
    Behav Neurosci 123:949-57. 2009
    ..The adaptations observed in multiparous females provide an innate model for the study of neuroplasticity in the regulation of aggression...
  92. pmc Associations of maternal prenatal smoking with child adiposity and blood pressure
    Emily Oken
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Avenue, Boston, MA 02215, USA
    Obes Res 13:2021-8. 2005
    ..To examine the extent to which maternal prenatal smoking is associated with adiposity, central adiposity, and blood pressure in 3-year-old children...
  93. ncbi Dopamine D(1) receptor activation of adenylyl cyclase, not phospholipase C, in the nucleus accumbens promotes maternal behavior onset in rats
    Danielle S Stolzenberg
    Department of Psychology, Boston College, Chestnut Hill, MA 02467, USA
    Horm Behav 57:96-104. 2010
    ..Activation of the mesolimbic DA system can produce an immediate onset of maternal behavior in these females...
  94. ncbi Male pheromones initiate prolactin-induced neurogenesis and advance maternal behavior in female mice
    Caroline M Larsen
    Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, Box 913, University of Otago, Dunedin 9001, New Zealand
    Horm Behav 53:509-17. 2008
    Prolactin is required for rapid onset of maternal behavior after parturition, inducing adaptive changes in the maternal brain including enhanced neurogenesis in the subventricular zone during pregnancy...
  95. ncbi Experiential and hormonal correlates of maternal behavior in teen and adult mothers
    Katherine M Krpan
    Department of Psychology, Erindale College, University of Toronto, N Mississauga, Ontario, Canada L5L 1C6
    Horm Behav 47:112-22. 2005
    This study explores the role of cortisol and early life experiences in the regulation of maternal behavior and mood in teen and adult mothers...
  96. ncbi Arginine vasopressin 1a receptor gene and maternal behavior: evidence of association and moderation
    R Bisceglia
    Department of Human Development and Applied Psychology, University of Toronto Toronto Western Research Institute, Toronto, ON, Canada
    Genes Brain Behav 11:262-8. 2012
    ..Mothers with two copies of the long RS3 alleles were less sensitive than mothers with one or zero copies of the long alleles. This association was strongest under conditions of high maternal early adversity...
  97. ncbi Misclassification of maternal smoking status and its effects on an epidemiologic study of pregnancy outcomes
    Lucinda J England
    Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Nicotine Tob Res 9:1005-13. 2007
    ..The potential for this type of bias should be considered when conducting and interpreting epidemiologic studies of smoking and pregnancy outcomes...
  98. ncbi Serotonin transporter allelic variation in mothers predicts maternal sensitivity, behavior and attitudes toward 6-month-old infants
    V Mileva-Seitz
    Institute of Medical Sciences, University of Toronto, Mississauga, Ontario
    Genes Brain Behav 10:325-33. 2011
    b>Maternal behavior in the new mother is a multidimensional set of responses to infant cues that are influenced by the mother's early life experiences...
  99. ncbi Maternal care received by individual pups correlates with adult CA1 dendritic morphology and synaptic plasticity in a sex-dependent manner
    F N van Hasselt
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands Rudolf Magnus Institute for Neurosciences, UMC Utrecht, Utrecht, The Netherlands
    J Neuroendocrinol 24:331-40. 2012
    ..The data from the present study suggest that %LG received early in life results in mild, yet sex-dependent effects on adult CA1 structure and function...
  100. ncbi Restraint stress impaired maternal behavior in female mice lacking the neuromedin B receptor (NMB-R) gene
    Kazuyuki Yamada
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira City, Tokyo 187 8502, Japan
    Neurosci Lett 330:163-6. 2002
    ..In the current study, we assessed the effects of stress on maternal behavior in female NMB-R-deficient mice...
  101. ncbi Recognizing intentions in infant-directed speech: evidence for universals
    Gregory A Bryant
    Department of Communication Studies, University of California, Los Angeles, CA 90095 1563, USA
    Psychol Sci 18:746-51. 2007
    ..This is the first demonstration that adult listeners in an indigenous, nonindustrialized, and nonliterate culture can accurately infer intentions from both ID speech and AD speech in a language they do not speak...

Research Grants65

  1. OXYTOCIN REGULATION BY NEUROSTEROIDS & GABA-A RECEPTOR
    Janet Amico; Fiscal Year: 2003
    ..is essential for milk ejection during lactation, enhances uterine contractility at parturition and induces maternal behavior in the rat. Maternal behavior in most mammals is stimulated by the hormonal milieu of late pregnancy...
  2. Identification of an Epigenetic Risk Marker for PTSD
    Rachel Yehuda; Fiscal Year: 2010
    ..the biological changes in these offspring reflect an enduring epigenetic modification, induced by early maternal behavior that resulted in 'recalibrating'the cortisol system in a manner that increases risk for subsequent ..
  3. QTL and QTL Genes Underlying Lactation Performance
    Darryl L Hadsell; Fiscal Year: 2010
    ..We have also measured milk composition, mammary gland mitochondrial function and maternal behavior, and conducted extensive analysis of mammary gland development and gene expression over the course of the ..
  4. HORMONE-NEUROTRANSMITTER INTERACTIONS IN THE BRAIN
    Elaine M Hull; Fiscal Year: 2011
    ..MPOA) is an important node for several social behaviors, including male and female sexual behaviors and maternal behavior. Perhaps the best predictor of a male rat's ability to copulate is extracellular dopamine (DA) in his ..
  5. Identifying Genetic Risk for Maternal Insensitivity and Infant Dysregulation
    Esther M Leerkes; Fiscal Year: 2013
    ..for parenting difficulties and the design of individually tailored intervention efforts to foster sensiive maternal behavior and positive social emotional functioning early in life...
  6. Maternal Brain and Behavioral Responses to Infant Cues in Cocaine Exposed Mothers
    Lane Strathearn; Fiscal Year: 2013
    ..However, little is known about how cocaine exposure affects brain circuits involved in maternal behavior, especially in humans...
  7. Inter-Parental Conflict, Maternal Behavior, and Mother-Child Physiology
    LEAH CORINNE HIBEL; Fiscal Year: 2012
    ..Specifically, we will be examining the effects of physiological reactivity surrounding marital conflict on maternal behavior and the infant's physiological reaction to, and ability to recover from distress with maternal support...
  8. Assessing the Influence of Oxytocin on Postpartum Depression Using Brain Imaging
    Julia R Heiman; Fiscal Year: 2010
    ..Importantly, the prefrontal-limbic system may mediate maternal behavior (Lorberbaum et al., 1999, Ranote et al., 2004;Seifritz et al., 2003;Swain et al., 2007)...
  9. Serotonin, Maternal Behavior and Postpartum Depression
    Ming Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Maternal behavior in rats is a highly motivated and well-organized social behavior...
  10. Implantable Minipump For Tetherless Drug Self-Administration In Mice
    DANIEL PHILIPP HOLSCHNEIDER; Fiscal Year: 2010
    ..This experimental tool will allow examination of the effects of complex behaviors (e.g. social behavior, maternal behavior) and complex environments on addiction...
  11. Cocaine disruption of maternal motivation: preference for pups vs. cocaine
    MARIANA PEREIRA ARBOLEYA; Fiscal Year: 2010
    ..is focused in the understanding of the neural substrate that mediates the motivational aspects of maternal behavior during the postpartum period, particularly within the context of the disruptive effects of drugs with high ..
  12. Origins of Maternal Sensitivity to Infant Distress
    Esther M Leerkes; Fiscal Year: 2012
    ..for parenting difficulties and the design of individually tailored intervention efforts to foster sensitive maternal behavior and positive social emotional functioning early in life...
  13. Prenatal Cocaine, Smoking And Oxytocin In Humans
    Karen M Grewen; Fiscal Year: 2010
    ..of normal maternal behaviors in mammals, and that describe the disruptions in both OT activity and maternal behavior resulting from perinatal cocaine exposure...
  14. Dopamine/Adenpsine interaction in depression: Therapeutic role of A2A antagonism
    MARIANA PEREIRA ARBOLEYA; Fiscal Year: 2013
    ..The first group of experiments will use maternal behavior analysis with simultaneous microdialysis sampling to examine whether alterations in DA release in discrete ..
  15. Maternal behavior and effects of paternal affiliation in 5-HT1a overexpressing mi
    Juan F Lopez; Fiscal Year: 2010
    ..Understanding the neurobiological factor(s) that may predispose to postpartum mood disorders and affect maternal behavior, as well as the factors that may be protective are therefore, of high clinical significance...
  16. Attention and Memory: Mother-Child Psychophysiology and Behavior
    Martha Ann Bell; Fiscal Year: 2010
    ..of genes that influence individual differences in executive attention and memory or the influence of maternal behavior on young children's developing self-regulation of these cognitive processes-although the mechanisms ..
  17. DOPAMINE REGULATION OF SOCIAL ATTACHMENT
    Zuoxin Wang; Fiscal Year: 2013
    ..Our knowledge about the neurobiology of parental behavior is almost exclusively derived from studies of maternal behavior, mainly because only ~3-5% of mammalian species display paternal behavior, and thus, an animal model has not ..
  18. Ontogeny of sociality in a mouse model
    Jeffrey R Alberts; Fiscal Year: 2012
    ..Finally, we will provide both global and specific measures of maternal behavior in the C57 mother mouse, for these data and their methods are needed for complete analyses of genetic and ..
  19. ENDOCRINE REGULATION OF MATERNAL BEHAVIOR
    Robert Bridges; Fiscal Year: 2009
    ..goal of this project is to identify the neural and neurochemical mechanisms underlying the regulation of maternal behavior and to elucidate potentially novel mechanisms of neural plasticity associated with the expression of ..
  20. Central Vasopressin and Maternal Behavior
    Benjamin C Nephew; Fiscal Year: 2010
    ..associated disorders can have negative effects on the health of both mother and offspring through effects on maternal behavior, and little is known about the etiology of these disorders...
  21. A Biopsychosocial Model of Emotion Processes Determining the Role of Overcontroll
    ELIZABETH JAYNE KIEL; Fiscal Year: 2013
    ..reactivity and emotion regulation) that determine when inhibited temperament predicts overcontrolling maternal behavior. Prior to the grant period, toddlers will be assessed observationally and via mother- and father-report for ..
  22. Maternal depression, family food behavior, and child nutritional health
    KAREN P MCCURDY; Fiscal Year: 2010
    ..food and/or excessive consumption of poor quality foods are the proximal causes of these behaviors, maternal behavior is particularly critical in determining access and availability of the food in a young child's ..
  23. Variance in sibling mothering received and adult mothering, anxiety and serotonin
    CHRISTINA RAGAN; Fiscal Year: 2013
    ..among siblings in maternal care received influences mechanisms related to later sibling differences in: 1) maternal behavior, 2) anxiety-like behaviors, and 3) serotonin synthesis and release...
  24. BABOON MODEL FOR STUDY OF PRIMATE MATERNAL BEHAVIOR
    Linda Y Brent; Fiscal Year: 2011
    ..b>Maternal behavior in primates is a complex process, involving a number of physiological and life history variables...
  25. Vasopressin and Maternal Behavior
    Benjamin C Nephew; Fiscal Year: 2013
    ..is a significant risk factor for depression, it is unknown how chronic stress during lactation affects maternal behavior. Recent molecular studies indicate that the neurohormones arginine vasopressin (AVP), oxytocin (OXT), and ..
  26. Cocaine Alterations of Maternal Dopamine Transients
    Donita L Robinson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Disruption of maternal behavior by substance abuse resulting in higher levels of maternal neglect towards infants is well documented in human and animal research, while the associated neural ..
  27. Communication on Illicit Drug and/or Alcohol Use in Obstetrics
    Judy C Chang; Fiscal Year: 2013
    ..and whether certain communication styles are more likely to elicit disclosure and/or inspire positive maternal behavior change...
  28. How Maternal Stress Influences Offspring Health &Development in Wild Chimpanzees
    CARSON MURRAY; Fiscal Year: 2013
    ..While elegant captive work demonstrates the transmission of maternal behavior and stress physiology across generations, they lack the ful! extent of environmental heterogeneity that is a ..
  29. Cocaine: Translational Effects on Infant Vocalizations and Maternal Response
    ELIZABETH THOMAS COX; Fiscal Year: 2011
    ..indicated that rodent mothers from both drug- treated and control groups exhibited delayed or lessened maternal behavior towards cocaine-exposed infants during the early postpartum period...
  30. Maternal behavior among Puerto Rican adolescent mothers
    JOSEFINA GRAU; Fiscal Year: 2009
    ..It uses a multi-method, longitudinal design to examine maternal behavior and child outcomes among 180 English- and Spanish-speaking Puerto Rican adolescent mothers and their ..
  31. Characterization of a Novel Mouse Model of Restricted Repetitive Behaviors
    Sheryl S Moy; Fiscal Year: 2010
    ..mouse strain as a model for RRB in humans, we will use a cross-fostering procedure to establish whether maternal behavior contributes to the emergence of RRB...
  32. Modification of Interpretation Bias for Intergenerational Anxiety Tranmission
    Thomas H Ollendick; Fiscal Year: 2013
    ..interpretation training, compared to the control condition, will result in less of this type of anxious maternal behavior, decreased perception of threat (i.e...
  33. COCAINE AND MATERNAL NEGLECT: INTERGENERATIONAL EFFECTS
    JOSEPHINE JOHNS; Fiscal Year: 2003
    ..treatment in postpartum dams both increase maternal neglect, defined as the disruption of pup-directed maternal behavior. Chronic cocaine treatment also increases postpartum maternal aggression towards intruders to the extent ..
  34. Mechanisms of Cognitive &Emotional Disturbances After Fragmented Early Life
    Tallie Z Baram; Fiscal Year: 2013
    ..Hence, the potential impact of the proposed studies is tremendous. ..
  35. Functional Neuroanatomy of Maternal & Paternal Behavior
    JEFFREY LORBERBAUM; Fiscal Year: 2006
    ..This work suggests that brain regions important in rodent maternal behavior also activate when human mothers hear infant cries...
  36. REPRODUCTIVE EFFECTS OF OXYTOCIN DEFICIENCY
    CHRISTINA LUEDKE; Fiscal Year: 2001
    ..In addition, much evidence has accumulated to suggest that oxytocin is essential for maternal behavior and important in sexual behavior...
  37. Neurochemical control of maternal behavior
    JOSEPH LONSTEIN; Fiscal Year: 2002
    ..The mPOA is necessary for some oral components of maternal behavior in rats, such as retrieval of pups, and plays a role in the motivation to act parentally...
  38. Intrinsic and Extrinsic Effects on Trajectories of Infants' Vagal Functioning
    Cathi Propper; Fiscal Year: 2009
    ..Further, maternal behavior toward her infant during a free play and puzzle task was video recorded for behavioral coding...
  39. Oxytocin, Postnatal Experience & Adult Maternal Behavior
    Cort Pedersen; Fiscal Year: 2006
    ..Specific Aim 1 is to examine in more detail the relationships between postnatal BMS and LMS and dams' maternal behavior, aggression, lactation changes in anxiety and central OT receptor binding...
  40. THE DEVELOPMENT OF EMOTIONAL SELF-REGULATION
    James Connell; Fiscal Year: 1992
    ..b>Maternal behavior will also be observed in the latter two paradigms and in a structured play paradigm to investigate relations ..
  41. INDUCTION OF MATERNAL BEHAVIOR BY ENDOGENOUS PEPTIDES
    Cort Pedersen; Fiscal Year: 1980
    ..that oxytocin administered intracerebroventricularly into virgin female rats induces rapid onset full maternal behavior. This phenomenon has been shown to be the estrogen-dependent...
  42. SENSATION AND BEHAVIOR IN FETUS AND NEWBORN
    April Ronca; Fiscal Year: 2001
    ..b>Maternal behavior and physiology provide abundant tactile, vestibular and thermal stimulation to fetal and newborn mammals...
  43. Maternal work schedules: Consequences for parenting and child development
    JOSEPH GRZYWACZ; Fiscal Year: 2007
    ..contributes to poorer developmental outcomes in children; (2) determine whether differences exist in maternal behavior (e.g...
  44. INFANTS RESPONSES TO MATERNAL UNRESPONSIVENESS
    Sybil Hart; Fiscal Year: 2000
    ..Infants' protests suggest perturbation, possibly due to their interpreting maternal behavior as representing emotional unavailability, and may be an early form of jealousy...
  45. Genetic and Caregiving Effects on Disordered Attachment
    Karlen Lyons Ruth; Fiscal Year: 2005
    ..and interactive statistical models of the relative contributions of genetic and nongenetic components of maternal behavior and infant disorganization to later psychopathology in the U.S. longitudinal cohort...
  46. NONAPEPTIDES AND MATERNAL BEHAVIOR ACTIVATION
    Cort Pedersen; Fiscal Year: 1999
    ..concerning the role of the nonapeptides oxytocin (OT) and arginine vasopressin (AVP) in the activation of maternal behavior (MB)...
  47. Opioid-Dopamine Interactions During Lactation
    LYDIA ARBOGAST; Fiscal Year: 2009
    ..Prolactin (PRL) is an anterior pituitary hormone which influences many aspects of lactation including maternal behavior, mammary gland development/ differentiation and the production of milk proteins...
  48. OXYTOCIN AND COCAINE--MATERNAL BEHAVIOR AND AGGRESSION
    JOSEPHINE JOHNS; Fiscal Year: 1999
    ..3) measure changes in OXY binding, levels and release in COC treated rat dams and (4) measure dopamine uptake in rat dams administered OXY. ..
  49. Neonatal Rearing and Adult Stress Reactivity in C57BL/6 Mice
    David Parfitt; Fiscal Year: 2007
    ..variables during differential rearing, such as time of day and isolation from siblings, for altering maternal behavior, adult behavior, stress-induced adrenocorticotropin hormone and corticosterone secretion, and mRNA ..
  50. Neural Changes Induced by Mating in the Female
    MARY ERSKINE; Fiscal Year: 2007
    In female rats, vaginocervical stimulation (VCS) received during mating or parturition modifies sexual and maternal behavior and induces neuroendocrine changes which influence reproductive success...
  51. BABOON MODEL FOR THE STUDY OF PRIMATE MATERNAL BEHAVIOR
    Linda Brent; Fiscal Year: 2003
    Most research on maternal behavior has focused on the endocrine control of maternal behavior in non-primate mammals or the relationship between experiential factors and maternal behavior in primates...
  52. PARENTAL BEHAVIOR IN MAMMALS--OPIOID REGULATION
    Robert Bridges; Fiscal Year: 1999
    ..The final set of studies will attempt to clarify the role of opioids during lactation in maternal behavior. Behaviors will be monitored in lactating rats after treatment with opiate antagonists to test the proposal ..
  53. DEVELOPMENTAL AND BEHAVIORAL NEUROENDOCRINOLOGY
    Seymour Levine; Fiscal Year: 1990
    ..and physiological effects of prolonged separation in squirrel monkey mother and infants; (b) whether maternal behavior from another adult conspecific ("aunt") can assume some of the functions of the attachment figure (mother); ..
  54. COCAINE DISRUPTION OF MATERNAL BEHAVIOR--RODENT MODELS
    JOAN MORRELL; Fiscal Year: 1993
    ..Therefore we propose to examine whether there is a cocaine-mediated derailment of maternal behavior in a well characterized laboratory model, the rat, and to examine the neurobiological basis of this affect...
  55. Experiential modulation of action patterns in the developing rat
    Michele R Brumley; Fiscal Year: 2010
    ..Experiments will manipulate maternal behavior to determine the role that maternal-infant interactions play in shaping the ontogeny of locomotor behavior ..
  56. OPIATE REGULATION AND INVOLVEMENT IN MATERNAL BEHAVIOR
    Robert Bridges; Fiscal Year: 1991
    The research in the present proposal examines the involvement of opiates in the normal regulation of maternal behavior and their regulation within the physiological context of pregnancy and lactatin...
  57. STRESS REACTIVITY AND EMOTION REGULATION
    Michael Lewis; Fiscal Year: 2000
    ..It is clear that infant emotion regulation also is influenced by differences in maternal behavior and in various family risk factors including marital discord, life stress, family hassles, and social ..
  58. PSYCHOBIOLOGY OF MATERNAL BEHAVIOR IN RABBITS
    JAY ROSENBLATT; Fiscal Year: 2001
    Pre-and early postpartum maternal behavior in the New Zealand white rabbit consists of an elaborate pattern of nestbuilding behavior that results in a straw nest built in a burrow, lined with loosened fur plucked from the female's ..
  59. How Maternal Stress Influences Offspring Health & Development in Wild Chimpanzees
    CARSON MURRAY; Fiscal Year: 2010
    ..identify key stressors for female chimpanzees, and to investigate the relationship between maternal stress, maternal behavior, and offspring development and health...
  60. Neuropeptide Involvement In Male Social Behavior
    JAMES KOENIG; Fiscal Year: 2009
    ..Specific Aim 1. Examine the role of maternal factors, like maternal behavior and glucocorticoids, in the prenatal stress-induced changes in adult male rat social behavior, ..
  61. PSYCHOBIOLOGY OF MATERNAL BEHAVIOR
    JAY ROSENBLATT; Fiscal Year: 1993
    This project will study the maternal behavior of the rabbit. This animal has a unique pattern of maternal behavior in which it nurses its young once daily for a brief period...
  62. FETAL LEARNING IN UTERO
    WILLIAM SMOTHERMAN; Fiscal Year: 1993
    ..advantages over neonatal study, because the fetus lacks experience with stimuli associated with suckling or maternal behavior. The fetus also can be maintained in an experimental setting that does not require active behavioral care by ..
  63. FETAL LEARNING IN UTERO
    WILLIAM SMOTHERMAN; Fiscal Year: 2001
    ..advantages over neonatal study, because the fetus lacks experience with stimuli associated with suckling or maternal behavior. The fetus also can be maintained in an experimental setting that does not require active behavioral care by ..
  64. The Function of Neurogenesis in the Mammalian Olfactory Bulb
    SHARI SAIDEMAN; Fiscal Year: 2009
    ..In addition, we will perform behavioral examinations of maternal behavior and pup development to address the functional cost of reduced neurogenesis...
  65. NEUROBIOLOGICAL BASIS OF PARENTAL BEHAVIOR
    Robert Bridges; Fiscal Year: 2001
    ..The first project examines the role of the endocrine system in regulating maternal behavior in female rats, while a second project evaluates the role of endogenous opioids in regulating the onset and ..