family

Summary

Summary: A social group consisting of parents or parent substitutes and children.

Top Publications

  1. pmc Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Lancet 373:234-9. 2009
  2. pmc Effect of a family focused active play intervention on sedentary time and physical activity in preschool children
    Mareesa V O'Dwyer
    Early Childhood Ireland, Hainault House, Belgard Square, Tallaght, Dublin 24, Ireland
    Int J Behav Nutr Phys Act 9:117. 2012
  3. ncbi Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Psychol Med 42:1-13. 2012
  4. ncbi Randomised clinical trial of a family-based lifestyle intervention for childhood obesity involving parents as the exclusive agents of change
    Felicity West
    The University of Queensland, Brisbane, QLD, Australia
    Behav Res Ther 48:1170-9. 2010
  5. pmc Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies
    A Antoniou
    Cancer Research U K Genetic Epidemiology Unit, Department of Public Health, University of Cambridge, Cambridge, United Kingdom
    Am J Hum Genet 72:1117-30. 2003
  6. pmc Rare variant analysis for family-based design
    Gourab De
    Department of Biostatistics, Harvard University, Boston, MA, USA
    PLoS ONE 8:e48495. 2013
  7. pmc A unique library of myogenic cells from facioscapulohumeral muscular dystrophy subjects and unaffected relatives: family, disease and cell function
    Sachiko Homma
    Neuromuscular Biology and Disease Group, Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Eur J Hum Genet 20:404-10. 2012
  8. ncbi Giardiasis among different tribes of Orang Asli in Malaysia: highlighting the presence of other family members infected with Giardia intestinalis as a main risk factor
    Tengku Shahrul Anuar
    Department of Parasitology and Medical Entomology, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
    Int J Parasitol 42:871-80. 2012
  9. pmc Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family
    Adam L Boxer
    UCSF Memory and Aging Center, University of California San Francisco, CA 94143, USA
    J Neurol Neurosurg Psychiatry 82:196-203. 2011
  10. ncbi Nurse-coordinated multidisciplinary, family-based cardiovascular disease prevention programme (EUROACTION) for patients with coronary heart disease and asymptomatic individuals at high risk of cardiovascular disease: a paired, cluster-randomised controlle
    D A Wood
    Department of Cardiovascular Medicine, National Heart and Lung Institute at Charing Cross Campus, Imperial College, London, UK
    Lancet 371:1999-2012. 2008

Detail Information

Publications355 found, 100 shown here

  1. pmc Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Lancet 373:234-9. 2009
    ..We aimed to assess genetic and environmental contributions to liability for schizophrenia, bipolar disorder, and their comorbidity...
  2. pmc Effect of a family focused active play intervention on sedentary time and physical activity in preschool children
    Mareesa V O'Dwyer
    Early Childhood Ireland, Hainault House, Belgard Square, Tallaght, Dublin 24, Ireland
    Int J Behav Nutr Phys Act 9:117. 2012
    ..This study describes the effectiveness of a family-focused 'Active Play' intervention in decreasing sedentary time and increasing total physical activity in ..
  3. ncbi Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective
    O J Bienvenu
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Psychol Med 42:1-13. 2012
    ..The current study uses co-morbidity and familiality data to inform these issues...
  4. ncbi Randomised clinical trial of a family-based lifestyle intervention for childhood obesity involving parents as the exclusive agents of change
    Felicity West
    The University of Queensland, Brisbane, QLD, Australia
    Behav Res Ther 48:1170-9. 2010
    ..and confidence in managing children's dietary and activity patterns, and in promoting a healthy lifestyle in their family. However, few studies assess changes in parenting over the course of treatment...
  5. pmc Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies
    A Antoniou
    Cancer Research U K Genetic Epidemiology Unit, Department of Public Health, University of Cambridge, Cambridge, United Kingdom
    Am J Hum Genet 72:1117-30. 2003
    ..higher risk and/or other familial risk factors, whereas risk estimates from studies based on cases unselected for family history have been imprecise...
  6. pmc Rare variant analysis for family-based design
    Gourab De
    Department of Biostatistics, Harvard University, Boston, MA, USA
    PLoS ONE 8:e48495. 2013
    ..Here we propose a novel method to test for association of rare variants obtained by sequencing in family-based samples by collapsing the standard family-based association test (FBAT) statistic over a region of interest...
  7. pmc A unique library of myogenic cells from facioscapulohumeral muscular dystrophy subjects and unaffected relatives: family, disease and cell function
    Sachiko Homma
    Neuromuscular Biology and Disease Group, Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Eur J Hum Genet 20:404-10. 2012
    ..We used this new collection to determine how family background and disease affected patterns of growth and differentiation, expression of a panel of candidate, and ..
  8. ncbi Giardiasis among different tribes of Orang Asli in Malaysia: highlighting the presence of other family members infected with Giardia intestinalis as a main risk factor
    Tengku Shahrul Anuar
    Department of Parasitology and Medical Entomology, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
    Int J Parasitol 42:871-80. 2012
    ..being a child aged less than 15 years, being male, the consumption of raw vegetables and the presence of other family members infected with G. intestinalis were the main risk factors for giardiasis...
  9. pmc Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family
    Adam L Boxer
    UCSF Memory and Aging Center, University of California San Francisco, CA 94143, USA
    J Neurol Neurosurg Psychiatry 82:196-203. 2011
    ..Previous studies have identified a region on chromosome 9p that is associated with FTD and ALS...
  10. ncbi Nurse-coordinated multidisciplinary, family-based cardiovascular disease prevention programme (EUROACTION) for patients with coronary heart disease and asymptomatic individuals at high risk of cardiovascular disease: a paired, cluster-randomised controlle
    D A Wood
    Department of Cardiovascular Medicine, National Heart and Lung Institute at Charing Cross Campus, Imperial College, London, UK
    Lancet 371:1999-2012. 2008
    Our aim was to investigate whether a nurse-coordinated multidisciplinary, family-based preventive cardiology programme could improve standards of preventive care in routine clinical practice.
  11. pmc Family-centred approaches to the prevention of mother to child transmission of HIV
    Theresa S Betancourt
    Francois Xavier Bagnoud Center for Health and Human Rights, Harvard School of Public Health, Harvard University, USA
    J Int AIDS Soc 13:S2. 2010
    ..narrow in scope, targeting biomedical interventions during the perinatal period, rather than considering HIV as a family disease...
  12. ncbi Risky families: family social environments and the mental and physical health of offspring
    Rena L Repetti
    Department of Psychology, University of California, Los Angeles, 90095 1563, USA
    Psychol Bull 128:330-66. 2002
    ..These family characteristics create vulnerabilities and/or interact with genetically based vulnerabilities in offspring that ..
  13. ncbi Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
  14. pmc Mutation analysis of CRYAA, CRYGC, and CRYGD associated with autosomal dominant congenital cataract in Brazilian families
    Alessandro Santana
    Cataract Service, Department of Ophthalmology, Faculty of Medical Sciences, Irmandade da Santa Casa de Misericordia de Sao Paulo, Sao Paulo, Brazil
    Mol Vis 15:793-800. 2009
    ..The purpose of this study was to investigate mutations in alphaA-crystallin (CRYAA), gammaC-crystallin (CRYGC), and gammaD-crystallin (CRYGD) in Brazilian families with nuclear and lamellar autosomal dominant congenital cataract...
  15. ncbi Family perspectives on end-of-life care at the last place of care
    Joan M Teno
    Center for Gerontology and Health Care Research, Brown Medical School, Providence, RI, USA
    JAMA 291:88-93. 2004
    ..Over the past century, nursing homes and hospitals increasingly have become the site of death, yet no national studies have examined the adequacy or quality of end-of-life care in institutional settings compared with deaths at home...
  16. pmc Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders
    Richard J L Anney
    Autism Genetics Group, Department of Psychiatry, Trinity College Dublin, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James Hospital, Dublin, Ireland
    Eur J Hum Genet 19:1082-9. 2011
    ..Both genes and processes that show enrichment have previously been examined in autistic disorders and offer biologically plausibility to these findings...
  17. ncbi Prevalence and characteristics of a family history of end-stage renal disease among adults in the United States population: Reasons for Geographic and Racial Differences in Stroke (REGARDS) renal cohort study
    William McClellan
    Georgia Medical Care Foundation, Emory University, Suite 200, Executive Park South NE, Atlanta, GA 30329 2224, USA
    J Am Soc Nephrol 18:1344-52. 2007
    This report describes the prevalence and characteristics of people with a family history of ESRD in a first-degree relative (FH-ESRD)...
  18. ncbi Suicide risk in relation to socioeconomic, demographic, psychiatric, and familial factors: a national register-based study of all suicides in Denmark, 1981-1997
    Ping Qin
    National Center for Register based Research, Aarhus University, Denmark
    Am J Psychiatry 160:765-72. 2003
    Suicide risk was addressed in relation to the joint effect of factors regarding family structure, socioeconomics, demographics, mental illness, and family history of suicide and mental illness, as well as gender differences in risk factors...
  19. pmc Family-based association analysis to finemap bipolar linkage peak on chromosome 8q24 using 2,500 genotyped SNPs and 15,000 imputed SNPs
    Peng Zhang
    Center for Computational Medicine and Bioinformatics Center for Statistical Genetics, Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Bipolar Disord 12:786-92. 2010
    ..We performed a detailed association analysis assessing the contribution of common genetic variation in this region to the risk of BP...
  20. ncbi A review of family and social determinants of children's eating patterns and diet quality
    Heather Patrick
    Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Coll Nutr 24:83-92. 2005
    With the growing problem of childhood obesity, recent research has begun to focus on family and social influences on children's eating patterns...
  21. ncbi Feeding the family during times of stress: experience and determinants of food insecurity in an Inuit community
    James D Ford
    McGill University, Montreal, Quebec
    Geogr J 177:44-61. 2011
    ....
  22. ncbi The role of parental motivation in family-based treatment for childhood obesity
    Thrudur Gunnarsdottir
    University of Iceland, Centre of Public Health, Reykjavik, Iceland
    Obesity (Silver Spring) 19:1654-62. 2011
    ..the role of parental motivation (importance, confidence and readiness) for predicting dropout and outcome from family-based behavioral treatment for childhood obesity...
  23. pmc Rare variant detection using family-based sequencing analysis
    Gang Peng
    Department of Bioinformatics and Computational Biology, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 110:3985-90. 2013
    ..Our method (Family-Based Sequencing Program, FamSeq) integrates Mendelian transmission information and raw sequencing reads...
  24. ncbi Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2
    Mary Claire King
    Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Science 302:643-6. 2003
    ..We selected 1008 index cases, regardless of family history of cancer, and carried out molecular analysis across entire families...
  25. pmc Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of leber hereditary optic neuropathy in Chinese families with the m.11778G-->a mutation
    Yanli Ji
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Am J Hum Genet 83:760-8. 2008
    ..These findings will assist in further understanding the pathogenesis of LHON and guide future genetic counseling in East Asian patients with m.11778G-->A...
  26. pmc Alcohol consumption and health status of family members: health impacts without ingestion
    W Liang
    National Drug Research Institute, Curtin University, Perth, Western Australia, Australia
    Intern Med J 43:1012-6. 2013
    ..It was very difficult to separate the hypothesised physiological protective effect of moderate drinking from its well-correlated confounders in observational study settings...
  27. pmc Elevation of fatty acid-binding protein 4 is predisposed by family history of hypertension and contributes to blood pressure elevation
    Hideki Ota
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Am J Hypertens 25:1124-30. 2012
    ..Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, and atherosclerosis. However, little is known about the role of FABP4 in essential hypertension...
  28. ncbi Familial aggregation of physical activity levels in the Québec Family Study
    Riita L Simonen
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 34:1137-42. 2002
    Familial aggregation of physical activity phenotypes was investigated in 696 subjects from 200 families of the Quebec Family Study. The mean age of offspring and parents was 27 and 53 yr, respectively.
  29. pmc Association of the type 2 diabetes mellitus susceptibility gene, TCF7L2, with schizophrenia in an Arab-Israeli family sample
    Anna Alkelai
    Biological Psychiatry Laboratory, Dept of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    PLoS ONE 7:e29228. 2012
    ..Further validation studies in additional populations are required...
  30. ncbi The impact of dental caries and trauma in children on family quality of life
    Jenny Abanto
    Department of Pediatric Dentistry and Orthodontics, Dental School, University of Sao Paulo USP, Sao Paulo, SP, Brazil
    Community Dent Oral Epidemiol 40:323-31. 2012
    To assess the impact of children's dental caries (DC) and traumatic dental injuries (TDI) on parents' quality of life (QoL), adjusted by family income.
  31. pmc Fatal family outbreak of Bacillus cereus-associated food poisoning
    Katelijne Dierick
    Institute of Public Health, Food Section, 14 Juliette Wijtsman Str, B 1050 Brussels, Belgium
    J Clin Microbiol 43:4277-9. 2005
    ..A fatal case due to liver failure after the consumption of pasta salad is described and demonstrates the possible severity of the emetic syndrome...
  32. pmc In search of triallelism in Bardet-Biedl syndrome
    Leen Abu-Safieh
    Developmental Genetics Unit, Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Eur J Hum Genet 20:420-7. 2012
    ..In no instance did we observe two mutations in unaffected members of a given family, or observe the presence of a third allele that convincingly acted as a modifier of penetrance and supported the ..
  33. ncbi Novel mutation in GLRB in a large family with hereditary hyperekplexia
    M Al-Owain
    Department of Medical Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Clin Genet 81:479-84. 2012
    ..This study presents a large family with HH as a result of homozygous mutation in GLRB and expands the clinical spectrum of HH to include eye ..
  34. ncbi Economic impact of dengue fever/dengue hemorrhagic fever in Thailand at the family and population levels
    Danielle V Clark
    Department of Virology, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 72:786-91. 2005
    ..of hospitalization, indirect costs due to loss of productivity, and the average number of persons infected per family, we observed a financial loss of approximately US$61 per family, which is more than the average monthly income in ..
  35. ncbi On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts, USA
    Genet Epidemiol 32:273-84. 2008
    ..In this paper, we propose a generalization of family-based association tests (FBATs) to allow for the analysis of CNVs at a genome-wide level...
  36. pmc Family pet ownership during childhood: findings from a UK birth cohort and implications for public health research
    Carri Westgarth
    School of Veterinary Science, Faculty of Health and Life Sciences, University of Liverpool, Leahurst Campus, Neston, Cheshire, CH64 7TE, UK
    Int J Environ Res Public Health 7:3704-29. 2010
    ..Logistic regression was used to build multivariable models for ownership of each pet type at age 7 years. Family pet ownership increased during childhood, in particular rabbits, rodents and fish...
  37. ncbi Family reactions during infants' hospitalization in the neonatal intensive care unit
    Michael L Spear
    Section of Neonatology, Department of Pediatrics, Christiana Care Health Services, Newark, Delaware, USA
    Am J Perinatol 19:205-13. 2002
    The purpose of this investigation is to assess family stress, coping, perceptions of their infant, and alterations in mood that may result from the hospitalization of their critically ill newborn infant...
  38. ncbi Stigma and expressed emotion: a study of people with schizophrenia and their family members in China
    Michael R Phillips
    Beijing Hui Long Guan Hospital, China
    Br J Psychiatry 181:488-93. 2002
    ..The most damaging effect of stigma is the internalisation of others' negative valuations...
  39. pmc Archetypal trajectories of social, psychological, and spiritual wellbeing and distress in family care givers of patients with lung cancer: secondary analysis of serial qualitative interviews
    Scott A Murray
    Primary Palliative Care Research Group, Centre for Population Health Sciences General Practice Section, University of Edinburgh, Edinburgh EH8 9DX
    BMJ 340:c2581. 2010
    To assess if family care givers of patients with lung cancer experience the patterns of social, psychological, and spiritual wellbeing and distress typical of the patient, from diagnosis to death.
  40. pmc Unemployment and mental health: understanding the interactions among gender, family roles, and social class
    Lucia Artazcoz
    Department of Experimental Sciences and Health, Universitat Pompeu Fabra, and the Agència de Salut Pública de Barcelona, Barcelona, Spain
    Am J Public Health 94:82-8. 2004
    We examined gender differences in the effects of unemployment on mental health and assessed whether such effects are associated with interactions among gender, family roles, and social class.
  41. pmc Predictors of family risk for celiac disease: a population-based study
    Alberto Rubio-Tapia
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 6:983-7. 2008
    There is an elevated prevalence of celiac disease (CD) in family members (FMs) of CD patients, but most prior studies have been done on selected populations...
  42. ncbi Family correlates of breakfast consumption among children and adolescents. A systematic review
    Natalie Pearson
    School of Sport and Exercise Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, United Kingdom
    Appetite 52:1-7. 2009
    ..The family environment is an important influence on the dietary behaviours of young people, and therefore we systematically ..
  43. ncbi Family-based designs for genome-wide association studies
    Jurg Ott
    Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 4A Datun Road, Chaoyang District, Beijing 100101, China
    Nat Rev Genet 12:465-74. 2011
    ..b>Family designs allow for control of population stratification, investigations of questions such as parent-of-origin ..
  44. ncbi The experience of cancer cachexia: a qualitative study of advanced cancer patients and their family members
    Joanne Reid
    Unit of Nursing and Midwifery Research, Queen s University Belfast Belfast Health and Social Care Trust, Lisburn Road, Belfast, UK
    Int J Nurs Stud 46:606-16. 2009
    ..In spite of advances in understanding the biomedical aspects of cancer cachexia, little attention has been paid to exploring its holistic impact on patients and those who care for them...
  45. ncbi Quality indicators of end-of-life cancer care from the bereaved family members' perspective in Japan
    Mitsunori Miyashita
    Department of Adult Nursing Palliative Care Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Pain Symptom Manage 37:1019-26. 2009
    ..several studies about quality indicators (QIs) in end-of-life (EOL) cancer care have been conducted, the bereaved family members' perspective of QIs has not been investigated in Japan...
  46. ncbi Recruitment and retention of participants in prevention trials involving family-based interventions
    R J Prinz
    Department of Psychology, University of South Carolina Prinz, Smith, Laughlin, White, Barron, Columbia, South Carolina 29208, USA
    Am J Prev Med 20:31-7. 2001
    b>Family-based preventive intervention trials in the area of child conduct problems face serious challenges regarding the recruitment and subsequent retention of participants...
  47. ncbi Are family meal patterns associated with disordered eating behaviors among adolescents?
    Dianne Neumark-Sztainer
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
    J Adolesc Health 35:350-9. 2004
    To examine associations between family meal patterns (frequency, priority, atmosphere, and structure of family meals) and disordered eating (unhealthy weight control behaviors, binge eating, and chronic dieting) in adolescent girls and ..
  48. ncbi A family with autosomal dominant leukodystrophy linked to 5q23.2-q23.3 without lamin B1 mutations
    A Brussino
    Department of Genetics, Biology and Biochemistry, University of Torino, and SCDU Medical Genetics, AOU San Giovanni Battista, Torino, Italy
    Eur J Neurol 17:541-9. 2010
    ..In a large Italian family, we recently identified a variant form of ADLD characterized clinically by absence of the autonomic dysfunction at ..
  49. ncbi Population-based screening for family history of end-stage renal disease among incident dialysis patients
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 25:529-35. 2005
    ....
  50. pmc Impact of community-acquired paediatric rotavirus gastroenteritis on family life: data from the REVEAL study
    Marie Van der Wielen
    The Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Belgium
    BMC Fam Pract 11:22. 2010
    ..Although the epidemiology of rotavirus gastroenteritis (RVGE) is well documented, there are few data on the impact of RVGE on the families of affected children...
  51. ncbi Family nutritional support improves survival, immune restoration and adherence in HIV patients receiving ART in developing country
    Charlotte Serrano
    HIV Hepatitis Department, Sainte Marguerite Hospital APHM, Marseille, France
    Asia Pac J Clin Nutr 19:68-75. 2010
    ..This evaluation program estimated the impact of family nutritional support during the first year of antiretroviral treatment in West Africa's sub-Sahara region...
  52. ncbi Physically active families - de-bunking the myth? A qualitative study of family participation in physical activity
    Janice L Thompson
    Department of Exercise, Nutrition and Health Sciences, University of Bristol, Bristol, UK
    Child Care Health Dev 36:265-74. 2010
    ..The need for more family-based interventions to increase physical activity is frequently cited in the literature; however, little is known ..
  53. pmc BRCA1 and BRCA2 germline mutations in Malaysian women with early-onset breast cancer without a family history
    Gaik Theng Toh
    Cancer Research Initiatives Foundation CARIF, Outpatient Centre, Subang Jaya Medical Centre, Selangor, Malaysia
    PLoS ONE 3:e2024. 2008
    ..A proportion of these cases may be attributable, at least in part, to genetic components, but to date, the contribution of genetic components to breast cancer in many of Malaysia's ethnic groups has not been well-characterised...
  54. ncbi Family impact of child oral and oro-facial conditions
    David Locker
    Community Dental Health Services Research Unit, Faculty of Dentistry, University of Toronto, Toronto, Canada
    Community Dent Oral Epidemiol 30:438-48. 2002
    The aim of this study was to develop and evaluate the Family Impact Scale, a measure of the family impact of child oral and oro-facial disorders. This formed one component of the Child Oral Health Quality of Life Instrument.
  55. ncbi Family and child-care provider influences on preschool children's fruit, juice, and vegetable consumption
    T A Nicklas
    Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nutr Rev 59:224-35. 2001
    ..Much remains to be learned about how these influences and practices affect the development of FJV preferences and consumption early in life...
  56. pmc Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry
    Elizabeth T Jacobs
    Arizona Cancer Center, University of Arizona, Tucson, USA
    Carcinogenesis 31:1412-6. 2010
    ..overall and by colorectal subsite and microsatellite instability (MSI) status using data from the Colon Cancer Family Registry. No gene-level relationships between RXRA or CASR and colorectal cancer overall were observed...
  57. pmc Are extended twin family designs worth the trouble? A comparison of the bias, precision, and accuracy of parameters estimated in four twin family models
    Matthew C Keller
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA
    Behav Genet 40:377-93. 2010
    ..By modeling observed covariances of twins' relatives in addition to twins themselves, extended twin family designs (ETFDs) require less stringent assumptions, can estimate many more parameters of interest, and should ..
  58. pmc Confirmation of family cancer history reported in a population-based survey
    Phuong L Mai
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7022, Rockville Pike, Bethesda, MD 20852, USA
    J Natl Cancer Inst 103:788-97. 2011
    Knowledge of family cancer history is essential for estimating an individual's cancer risk and making clinical recommendations regarding screening and referral to a specialty cancer genetics clinic...
  59. ncbi Factors considered important at the end of life by patients, family, physicians, and other care providers
    K E Steinhauser
    Veterans Affairs Medical Center 152, 508 Fulton St, Durham, NC 27705, USA
    JAMA 284:2476-82. 2000
    ..Empirical evidence defining such factors, however, is lacking...
  60. ncbi Predictors of HIV-1 serostatus disclosure: a prospective study among HIV-infected pregnant women in Dar es Salaam, Tanzania
    G Antelman
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    AIDS 15:1865-74. 2001
    ..Lack of disclosure may have limited their ability to engage in preventive behaviors or to obtain the necessary emotional support for coping with their serostatus or illness...
  61. ncbi Family caregivers' subjective experiences of satisfaction in dementia care: aspects of burden, subjective health and sense of coherence
    Signe Andrén
    Division of Geriatric Medicine, Department of Community Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    Scand J Caring Sci 19:157-68. 2005
    b>Family caregivers experience both positive and negative reactions in caregiving situations. There has been considerably less published about the positive aspects, however...
  62. pmc A Chinese family with progressive childhood cataracts and IVS3+1G>A CRYBA3/A1 mutations
    Yanan Zhu
    Eye Center of the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
    Mol Vis 16:2347-53. 2010
    To characterize the disease-causing mutations in a Chinese family with progressive childhood cataracts.
  63. pmc A novel mutation in the major intrinsic protein (MIP) associated with autosomal dominant congenital cataracts in a Chinese family
    Wei Wang
    Eye Center of the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
    Mol Vis 16:534-9. 2010
    To detect the underlying genetic defect in a Chinese family affected with bilateral congenital cataracts.
  64. ncbi Circulating 25OHD, dietary vitamin D, PTH, and calcium associations with incident cardiovascular disease and mortality: the MIDSPAN Family Study
    Paul Welsh
    Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
    J Clin Endocrinol Metab 97:4578-87. 2012
    ..Observational studies relating circulating 25-hydroxyvitamin D (25OHD) and dietary vitamin D intake to cardiovascular disease (CVD) have reported conflicting results...
  65. pmc Neurocognition in youth and young adults under age 30 at familial risk for schizophrenia: a quantitative and qualitative review
    Jessica Agnew-Blais
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Cogn Neuropsychiatry 18:44-82. 2013
    ..Studying nonpsychotic relatives ("familial high-risk", or FHR) allows for identification of cognitive vulnerability markers independent of confounds associated with psychosis...
  66. pmc A novel missense SNRNP200 mutation associated with autosomal dominant retinitis pigmentosa in a Chinese family
    Tiecheng Liu
    Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China
    PLoS ONE 7:e45464. 2012
    ..In this work, we analyzed a Chinese family with adRP and identified a novel missense mutation in SNRNP200...
  67. ncbi The impact of midlife educational, work, health, and family experiences on men's early retirement
    Marleen Damman
    Netherlands Interdisciplinary Demographic Institute, P O Box 11650, 2502 AR The Hague, The Netherlands
    J Gerontol B Psychol Sci Soc Sci 66:617-27. 2011
    ..aims to improve our understanding of retirement by examining the impact of midlife educational, work, health, and family experiences on early retirement intentions and behavior...
  68. ncbi Family-related predictors of body weight and weight-related behaviours among children and adolescents: a systematic umbrella review
    A Cislak
    Warsaw School of Social Sciences and Humanities, Warsaw, Poland
    Child Care Health Dev 38:321-31. 2012
    This umbrella review analysed the relationships between family variables and child/adolescent body weight, diet and physical activity...
  69. ncbi Family burden in long-term diseases: a comparative study in schizophrenia vs. physical disorders
    Lorenza Magliano
    Department of Psychiatry, University of Naples, Largo Madonna delle Grazie, I 80138 Naples, Italy
    Soc Sci Med 61:313-22. 2005
    ..Each relative was asked to fill in the Family Problems Questionnaire (FPQ) and the Social Network Questionnaire (SNQ)...
  70. ncbi Nursing home placement: an exploration of the experiences of family carers
    A A Ryan
    University of Ulster, Coleraine, Co Londonderry, Northern Ireland
    J Adv Nurs 32:1187-95. 2000
    This study examines some of the factors leading family carers to place their older relatives in a nursing home. It also explores their thoughts and feelings about their relatives' admission to a nursing home...
  71. pmc Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and case-control studies
    Yelena Bykhovskaya
    Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Division of Surgical Research, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Invest Ophthalmol Vis Sci 53:4152-7. 2012
    ..To determine whether LOX is a genetic determinant of the pathogenesis of keratoconus, we analyzed association results of LOX polymorphisms in two independent case-control samples and in keratoconus families...
  72. ncbi The role of the family and improvement in treatment maintenance, adherence, and outcome for schizophrenia
    Ira D Glick
    Psychiatry and Behavioral Sciences, Schizophrenia Research Program, Stanford University School of Medicine, Stanford, CA, USA
    J Clin Psychopharmacol 31:82-5. 2011
    ..study evaluating the relative effectiveness and safety of antipsychotic medication (CATIE), we examined the relationship between treatment outcome and 2 family variables: their presence and their ability to support treatment adherence.
  73. ncbi Arrhythmogenic right ventricular dysplasia/cardiomyopathy: pathogenic desmosome mutations in index-patients predict outcome of family screening: Dutch arrhythmogenic right ventricular dysplasia/cardiomyopathy genotype-phenotype follow-up study
    Moniek G P J Cox
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 123:2690-700. 2011
    ..Previous genotype-phenotype relation studies involved mainly overt ARVD/C index patients, so follow-up data on relatives are scarce...
  74. pmc A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity
    H Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
    Int J Geriatr Psychiatry 28:57-65. 2013
    This study examined the effects of brief daily yogic meditation on mental health, cognitive functioning, and immune cell telomerase activity in family dementia caregivers with mild depressive symptoms.
  75. ncbi Broader autism phenotype: evidence from a family history study of multiple-incidence autism families
    J Piven
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, USA
    Am J Psychiatry 154:185-90. 1997
    ..The objective of this study was to examine behaviors that may define this broader phenotype in relatives ascertained through two autistic siblings...
  76. pmc Women's higher likelihood of disability pension: the role of health, family and work. A 5-7 years follow-up of the Hordaland Health Study
    Inger Haukenes
    Department of Public Health and Primary Health Care, University of Bergen, Kalfarveien 31, NO 5018, Bergen, Norway
    BMC Public Health 12:720. 2012
    ..The aim of the study was to examine the extent to which self-perceived health, family situation and work factors explain women's higher risk of disability pension...
  77. ncbi Mastery, burden, and areas of concern among family caregivers of mentally ill persons
    Linda E Rose
    The Johns Hopkins University, School of Nursing, Baltimore, MD 21205, USA
    Arch Psychiatr Nurs 20:41-51. 2006
    In an era of limited resources for mental health care, family interventions need to target areas where they are responsive to families' expressed needs...
  78. ncbi The accuracy of surrogate decision makers: a systematic review
    David I Shalowitz
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Intern Med 166:493-7. 2006
    ..However, commentators have questioned the accuracy with which surrogates predict patients' treatment preferences...
  79. ncbi Parenting styles, family structure and adolescent dietary behaviour
    Natalie Pearson
    School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK
    Public Health Nutr 13:1245-53. 2010
    To examine associations between parenting styles, family structure and aspects of adolescent dietary behaviour.
  80. pmc Familial identification: population structure and relationship distinguishability
    Rori V Rohlfs
    Department of Integrative Biology, University of California Berkeley, Berkeley, California, USA
    PLoS Genet 8:e1002469. 2012
    ..Implementation of familial searching has been proposed to extend forensic identification to family members of individuals with profiles in offender/arrestee DNA databases...
  81. ncbi The Virtual Family--development of surface-based anatomical models of two adults and two children for dosimetric simulations
    Andreas Christ
    Foundation for Research on Information Technologies in Society, Zeughausstr 43, 8004 Zurich, Switzerland
    Phys Med Biol 55:N23-38. 2010
    ..These four models are referred to as the Virtual Family. They are based on high resolution magnetic resonance (MR) images of healthy volunteers...
  82. ncbi Stress, social support, and HIV-status disclosure to family and friends among HIV-positive men and women
    Seth C Kalichman
    Center for AIDS Intervention Research Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    J Behav Med 26:315-32. 2003
    ..Structured interviews assessed HIV-status disclosure to family and friends, perceived stress of disclosure, social support, and depression...
  83. ncbi Family support and family-centered care in the neonatal intensive care unit: origins, advances, impact
    Judith S Gooding
    NICU Initiatives and Chapter Program Strategy, Chapter Program Support, March of Dimes Foundation, White Plains, NY 10605, USA
    Semin Perinatol 35:20-8. 2011
    b>Family-centered care (FCC) has been increasingly emphasized as an important and necessary element of neonatal intensive care...
  84. ncbi Forensic utilization of familial searches in DNA databases
    Cassandra J Gershaw
    John Jay College of Criminal Justice, North Hall, New York, NY 10019, USA
    Forensic Sci Int Genet 5:16-20. 2011
    ..This article discusses prospective positive outcomes of utilizing familial DNA searches and acknowledges potential negative outcomes, thereby presenting both sides of this very complicated, rapidly evolving situation...
  85. ncbi The endophenotype concept in psychiatry: etymology and strategic intentions
    Irving I Gottesman
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55454, USA
    Am J Psychiatry 160:636-45. 2003
    ..The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics...
  86. pmc Genomic identification in the historical case of the Nicholas II royal family
    Evgeny I Rogaev
    Department of Genomics and Laboratory of Evolutionary Genomics, Vavilov Institute of General Genetics, Russian Academy of Science, Gubkina Street, 3, Moscow, 119991, Russian Federation
    Proc Natl Acad Sci U S A 106:5258-63. 2009
    ..The controversy surrounding the fate of the last Russian Emperor, Nicholas II, and his family has persisted, in part, because the bodies of 2 children, Prince Alexei and 1 of his sisters, have not been found...
  87. ncbi Family communication about positive BRCA1 and BRCA2 genetic test results
    Bobbi McGivern
    Clinical Cancer Genetics, MD Anderson Cancer Center, Houston, Texas, USA
    Genet Med 6:503-9. 2004
    ..information to individuals who receive this result, but it can also provide crucial cancer risk information to family members. Most of the research on communication of genetic test results has focused on first degree relatives...
  88. ncbi Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholism
    Xing Dai
    Douglas Hospital Research Centre and the Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Alcohol Clin Exp Res 29:1965-75. 2005
    ..The objective of the present studies was to test the hypothesis that there are differences in the response of the pituitary beta-endorphin system to stress as a function of family history of alcoholism and alcohol dependence.
  89. pmc Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescence
    Gregory E Miller
    University of British Columbia, 2136 W Mall Ave, Vancouver, British Columbia, Canada V6T 1Z4
    Psychol Sci 21:848-56. 2010
    ..If sustained, these tendencies may place children from harsh families on a developmental trajectory toward the chronic diseases of aging...
  90. ncbi Molecular genetics of attention-deficit/hyperactivity disorder
    Stephen V Faraone
    Medical Genetics Research Center and Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    Biol Psychiatry 57:1313-23. 2005
    ..We review this literature, with a particular emphasis on molecular genetic studies. Family, twin, and adoption studies provide compelling evidence that genes play a strong role in mediating susceptibility ..
  91. pmc Large novel deletions detected in Chinese families with aniridia: correlation between genotype and phenotype
    Xiaohui Zhang
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
    Mol Vis 17:548-57. 2011
    ..To describe the clinical and genetic findings in two Chinese families with aniridia and other ocular abnormalities...
  92. ncbi Association of DRD2 variants and Gilles de la Tourette syndrome in a family-based sample from a South American population isolate
    Ibi Herzberg
    Research Department of Genetics, Evolution and Environment, University College London
    Psychiatr Genet 20:179-83. 2010
    ..Our findings replicate the association of DRD2 and GTS, and are consistent with the proposed connection between the dopamine system and this complex neuropsychiatric disease...
  93. ncbi Review of the literature on the effects of caring for a patient with cancer
    Una Stenberg
    Center for Shared Decision Making and Nursing Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Psychooncology 19:1013-25. 2010
    To adequately help family caregivers (FCs) of cancer patients, clinicians need to understand the complexity of the problems and responsibilities associated with cancer patients illness that FCs experience.
  94. ncbi Family members' perceived needs for bereavement follow-up
    Anna Milberg
    Department of Social and Welfare Studies, Linkoping University, Linkoping, Sweden
    J Pain Symptom Manage 35:58-69. 2008
    ..The study design was cross-sectional and targeted family members three to nine months after the patient's death...
  95. ncbi Kin recognition signals in adult faces
    Lisa M DeBruine
    School of Psychology, University of Aberdeen, Aberdeen AB24 2UB, UK
    Vision Res 49:38-43. 2009
    ..Using adult sibling faces, we find that similarity ratings for same-sex pairs were significantly higher than for opposite-sex pairs, suggesting that similarity judgments of adult faces are not entirely synonymous with kinship judgments...
  96. pmc Family member satisfaction with end-of-life decision making in the ICU
    Cynthia J Gries
    Division of Pulmonary and Critical Care, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Chest 133:704-12. 2008
    ..The identification of chart-based quality indicators of palliative care that predict family satisfaction with decision making may help to guide interventions to improve decision making and family outcomes.
  97. ncbi Socio-economic impact of tuberculosis on patients and family in India
    R Rajeswari
    Tuberculosis Research Centre, Indian Council of Medical Research, Chetput, Chennai, India
    Int J Tuberc Lung Dis 3:869-77. 1999
    ..To quantify the socio-economic impact of tuberculosis on patients and their families from the costs incurred by patients in rural and urban areas...
  98. pmc Individual, family, and neighborhood factors distinguish resilient from non-resilient maltreated children: a cumulative stressors model
    Sara R Jaffee
    Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Child Abuse Negl 31:231-53. 2007
    ..Which individual, family, and neighborhood characteristics distinguish resilient from non-resilient maltreated children? Do children's ..
  99. pmc Family health care decision making and self-efficacy with patients with ALS at the end of life
    Marie T Nolan
    School of Nursing, Berman Institute of Bioethics, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Palliat Support Care 6:273-80. 2008
    ..This study compared the preferences of patients with ALS for involving family in health care decisions at the end of life with the actual involvement reported by the family after death.
  100. ncbi Impact of colorectal cancer on patient and family: implications for care
    Hortense Cotrim
    Department of Nursing, Health School Egas Moniz, Instituto Superior de saude Egas Moniz, Caparica, Portugal
    Eur J Oncol Nurs 12:217-26. 2008
    The quality of life of a colorectal cancer patient and his family is deeply modified when faced with this diagnosis as a result of physical and psychological changes induced by it...
  101. ncbi Loneliness, social support and family function of people living with HIV/AIDS in Anhui rural area, China
    Y H Sun
    Department of Epidemiology and Statistics, School of Public Health, Anhui Medical University, Hefei 230032, China
    Int J STD AIDS 20:255-8. 2009
    The main purpose of this study was to investigate how loneliness was associated with social support and family function among people living with HIV/AIDS (PLWHA) in an HIV-stricken area of China...

Research Grants73

  1. REGULATION AND FUNCTION OF STE20-RELATED PROTEIN KINASES
    Melanie H Cobb; Fiscal Year: 2012
    ..WNK1 is essential for embryonic development in mice. The best known function of WNK family members is their influence on ion balance...
  2. Cellular &Molecular Defects in Human B Cell Development
    Charlotte Cunningham-Rundles; Fiscal Year: 2013
    ..We hypothesize that mutations in this receptor and its isoforms can be used to elucidate the complex functions of this receptor in a human system. ..
  3. THE ETHICS OF POST-CONFLICT AND POST-DISASTER DNA IDENTIFICATION
    Sarah Wagner; Fiscal Year: 2013
    ..Finally, the research team will publish a collection of oral histories documenting the family and community perspective on missing persons in a book series for lay readers called Voice of Witness...
  4. AAA ATPases linking mitochondria with microtubule processing in flies and yeast
    Karen G Hales; Fiscal Year: 2012
    ..Since various observations initially suggest a conserved role for Nmd family members in both mitochondrial shaping and microtubule processing, the primary emphasis in the proposed research is ..
  5. Celiac Disease: From Genetic Risk to Disease Development
    Susan L Neuhausen; Fiscal Year: 2009
    ..to a gluten-free diet? To investigate these questions, we will recontact individuals previously enrolled in two family studies, one at the University of California Irvine and one at Mayo Clinic, in which we had systematically ..
  6. Novel Catalases and their Products
    Alan R Brash; Fiscal Year: 2013
    ..will provide new insights and a new way of thinking about the enzymatic capabilities of a long-recognized protein family with established roles as a sentinel at the forefront of oxidative defense...
  7. Evolutionary Analysis of the Histone Deacetylase Family: Biomedical Research
    JOSEPH LEWIS GRAVES; Fiscal Year: 2011
    ..seeks to utilize evolutionary methods to examine molecular signatures of positive in the histone deacetylase family (HDAC's...
  8. Social Networks &Breast Cancer Prognosis in the Chinese and US Evaluation Study
    Candyce H Kroenke; Fiscal Year: 2013
    ..I we demonstrate these findings, family interventions previously employed to improve lifestyle factors in persons with cardiovascular conditions might ..
  9. DNA METHYLOME STUDY IN TYPE 1 DIABETES
    ART PETRONIS; Fiscal Year: 2009
    ..test germline samples of fathers who have children with T1D and are also affected with T1D themselves or have a family history of T1D...
  10. The Metabolic Impact of Congenital Heterozygous ApoC-III Deficiency in Humans
    TONI ILANA POLLIN; Fiscal Year: 2013
    ..This project will look more closely at the effects of the deficiency on human metabolism to better understand the function of the apoC-III protein and its potential as a drug target. ..
  11. SGK Regulation of Epithelial Sodium Transport
    David Pearce; Fiscal Year: 2013
    ..C) Examine the role of mTOR in regulation of amiloride-inhibitable currents in isolated CCD using patch clamp. ..
  12. Molecular probes for a vOTU from CCHFV using a fluorogenic peptide
    SCOTT DUSAN PEGAN; Fiscal Year: 2013
    ....
  13. Phenotypic Spectrum of LRRK2 Mutations
    Rachel Saunders-Pullman; Fiscal Year: 2013
    ..As noted, this study will expand on a large Consortium study of a unique cohort of Ashkenazi Jews with PD, family members and controls, by adding measures and new analyses...
  14. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey C Murray; Fiscal Year: 2013
    ..Additional genotyping of the extended family members with subphenotyping will then better inform gene finding and phenotype correlations...
  15. Exploiting toxins to probe sensory signaling
    David Julius; Fiscal Year: 2012
    ..With this in mind, we have recently discovered a novel family of peptide toxins from tarantula that activate the capsaicin receptor, TRPV1, to produce inflammatory pain (..
  16. RNA quality control and environmental stress
    Sandra L Wolin; Fiscal Year: 2013
    ....
  17. Structural Rearrangements in GABA-A Receptors
    CYNTHIA M CZAJKOWSKI; Fiscal Year: 2012
    ....
  18. The Ecology, Emergence and Pandemic Potential of Nipah virus in Bangladesh
    Peter Daszak; Fiscal Year: 2012
    ..Our work will examine why this virus is emerging, and help provide an early warning system for Nipah virus in Bangladesh. It will also give us a better understanding of the likelihood of this and other pathogens becoming pandemic. ..
  19. Control of bacterial morphology and differentiation
    Yves V Brun; Fiscal Year: 2013
    ..Insights gained from these studies can be used to design strategies to inhibit growth, prevent key morphological changes, or alter important protein localization pathways in pathogens, thereby improving our ability to control them. ..
  20. Multigenerational FamIlial and Environmental Risk for Autism (MINERvA) Network
    Abraham Reichenberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Better understanding of the etiologic roles of family history, prenatal environmental factors, and potential biologic mechanisms, such as epigenetic changes, in autism spectrum disorders (ASD) are ..
  21. Environmental Determinants of Autoimmunity among African Americans in Coastal SC
    Diane L Kamen; Fiscal Year: 2012
    ....
  22. Pre-BCR Function Selecting Novel B Cell Receptors in Chronic Lymphocytic Leukemia
    Kyoko Hayakawa; Fiscal Year: 2010
    ....
  23. Identifying New Regulators of Leptin-Like Signaling in Drosophila Brain Neurons
    KAI G ZINN; Fiscal Year: 2013
    ..Negative regulators identified in these experiments might be potential drug targets whose inhibition could upregulate anorexigenic leptin signaling in leptin-resistant obese individuals. ..
  24. Clinical Risk Prediction Modeling in Rheumatoid Arthritis
    Elizabeth W Karlson; Fiscal Year: 2013
    ..prediction models to predict 5-year RA risk for all RA and for subsets defined by sex, immune phenotype, and family history: (a) an "environmental" model using behavioral factors, environmental exposures, and clinical factors , ..
  25. The Role of Plasmids in Rickettsia Biology
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..The results of this research may provide new tools to control Rickettsia infections of humans. ..
  26. Investigational Safety and Toxicity Studies of Subcutaneous COG1410 for Alzheimer
    MICHAEL PETER VITEK; Fiscal Year: 2013
    ..or about 20% of their combined programs on the care of AD patients, as there is no effective treatment, and family caregivers spent at least $94 Billion more on caring for relatives with AD...
  27. Genetics of Parkinsonism in a Special Population of Untreated Schizophrenia
    Gabriel Alejandro De Erausquin; Fiscal Year: 2013
    ..Lastly, we anticipate that our research strategy may indicate new waysto study and address the increased vulnerability of schizophrenic patients to nicotine dependence. ..
  28. The Roles of Fat3 and Atrophin-2 in Jaw-Joint Development in Zebrafish
    Pierre Le Pabic; Fiscal Year: 2013
    ..Most of the techniques employed under this award will be learned by the candidate under the supervision of his sponsor, and will prepare him for a career as a Principal Investigator in the field of developmental biology. ..
  29. Evolution of Drosophila melanogaster cis-regulatory modules
    Aaron Hardin; Fiscal Year: 2013
    ....
  30. Pathways from genotype and environment to melanoma
    Nicholas K Hayward; Fiscal Year: 2012
    ..We also have >4000 DNA samples from adolescent twins and their family members for whom we have nevus counts and pigmentary phenotypes...
  31. Virulence factor identification by comparative transcriptomics in Candida species
    Michael C Lorenz; Fiscal Year: 2013
    ....
  32. Understanding early events in lupus autoimmunity to aid prevention
    Judith A James; Fiscal Year: 2013
    ....
  33. Advanced Naturally Designed Channelrhodopsins for Photocontrol of Neural Activity
    JOHN LEE SPUDICH; Fiscal Year: 2010
    ....
  34. Genome-Wide Targeted Gene Resequencing in Glaucoma
    THERESA GAASTERLAND; Fiscal Year: 2010
    ....
  35. Genomics of Primary Biliary Cirrhosis
    Konstantinos N Lazaridis; Fiscal Year: 2013
    ..and outcomes, prospectively collected questionnaire data regarding life-styles, environmental exposures, and family history, as well as biospecimens including DNA, serum, plasma, and lymphoblastoid cell-lines (LCLs)...
  36. DEVELOPING PET AGENTS FOR IMAGING PHOSPHODIESTERASE 10A (PDE10A)
    Zhude Tu; Fiscal Year: 2012
    ..A PET radiotracer of PDE10A may help physician to quantify the progression of Huntington Disease based on the PET measurement of PDE10A level in patients with the Huntington disease patients. ..
  37. Structural Studies and Char. of Neurotoxic Venom Peptides from Sicariidae Spiders
    NIKOLAUS MARTIN LOENING; Fiscal Year: 2012
    ..In addition, some venom peptides are species-specific and therefore have the potential to be used as environmentally-friendly insecticidal toxins. ..
  38. Role of autoantibody isotype in pemphigus pathogenesis
    Aimee S Payne; Fiscal Year: 2013
    ..As similar isotype profiles occur in pemphigoid, epidermolysis bullosa acquisita, and other chronic autoimmune conditions, our studies may have therapeutic relevance for a broad range of autoantibody-mediated diseases. ..
  39. An iPS Disease-in-a-Dish Model of Familial Alzheimers
    Terrence Town; Fiscal Year: 2012
    ..If successful, this exciting disease-in-a-dish model could allow pre-clinical testing of therapeutic approaches. ..
  40. RA-Related Autoantibodies in Healthy FDR of RA Patients
    Jill M Norris; Fiscal Year: 2011
    ....
  41. Leveraging genetics and environment to predict presymptomatic multiple sclerosis
    Zongqi Xia; Fiscal Year: 2013
    ..that such an algorithm can provide MS risk stratification for asymptomatic subjects at risk of MS, such as family members or patients with Radiologically Isolated Syndrome (RIS: asymptomatic individuals with incidental findings ..
  42. Decision Making in Unaffected First-Degree Relatives of Prostate Cancer Patients
    Clement Gwede; Fiscal Year: 2009
    ..the controversy, many men who are likely to develop prostate cancer including African American men and men with a family history of prostate cancer, remain uncertain about whether to take the PSA test or not to take the test;and often ..
  43. Disclosing Genomic Incidental Findings in a Cancer Biobank: An ELSI Experiment
    Susan M Wolf; Fiscal Year: 2013
    ..Working Group, we will conduct an experiment designed to develop strategies for offering incidental findings to family members of probands in a biobank for pancreatic cancer...
  44. Molecular characterization of novel loci for orofacial clefting using canine mode
    Danika L Bannasch; Fiscal Year: 2013
    ..4 Mb each. By comparing genotypes of family members, both regions were shown to be inherited as independent simple recessive traits...
  45. Gene regulatory network evolution and the origin of biological novelties
    MARK MARTINDALE; Fiscal Year: 2013
    ..These novel data will provide insight into the significance of variations in the GRNs in different systems and suggest specific gene interactions involved in abnormalities in endomesodermal development. ..
  46. Training in Neurogenetics: Function of NUP107 in Human and Mouse
    Bethany N Sotak; Fiscal Year: 2012
    ..I have identified a new causative gene, NUP107, and propose to study induced-pluripotent stem cells and knockout mice to model this human disease. ..
  47. Penn Center for ELSI Research in Emerging Genetic Technologies in Health Care
    Reed E Pyeritz; Fiscal Year: 2012
    ..genetic makeup will lead to better health, improved treatments and a better understanding of risks to other family members...
  48. Genes contributing for nicotine dependence in humans
    Kari Stefansson; Fiscal Year: 2013
    ....
  49. CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISM
    Kenneth Kidd; Fiscal Year: 2009
    ..Indications of the importance to alcoholism of different genetic variants and of which haplotypes may harbor cryptic but functionally relevant variation will result from these studies. ..
  50. Adipocyte insulin signaling and circulating adiponectin levels
    ROCIO INES PEREIRA; Fiscal Year: 2010
    ..The anticipated results of this clinical study may provide new insight into potential therapeutic targets in patients with T2DM, obesity, and MetS. ..
  51. Role of Neuropeptide S in age-related cognitive decline
    Olivier Civelli; Fiscal Year: 2012
    ..The study is both exploratory and translational and could lead to a better understanding of neural mechanisms underlying cognitive aging. ..
  52. Prediction Model: Breast Cancer in Women Irradiated for a Pediatric Malignancy
    Chaya Moskowitz; Fiscal Year: 2013
    ..of radiation to the chest, other treatment-related factors, the traditional breast cancer risk factors such as family and reproductive histories, and other non-treatment related risk factors...
  53. Natural History of MYH9-Associated Nephropathy
    BARRY IRA FREEDMAN; Fiscal Year: 2012
    ..of this project are: (1) recruitment of 1,200 unrelated African American subjects at high risk for HN based upon family history of H-ESRD, with phenotyping for the presence of hypertension, kidney disease and kidney disease-risk ..
  54. Medical Consequences of Long-Term Anabolic-Androgenic Steroid Abuse
    Harrison G Pope; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The anabolic-androgenic steroids (AAS) are a family of hormones that includes testosterone and its synthetic derivatives...
  55. MRI and Neuropsychological Findings in Schizophrenia, ADHD and Healthy Controls
    MARTHA ELIZABETH SHENTON; Fiscal Year: 2010
    ..The proposed study will investigate important scientific topics relevant to global health, schizophrenia and ADHD, both of which cause significant burden on society globally. ..
  56. Metabolic Syndrome in PCOS: Precursors and Interventions
    Andrea Dunaif; Fiscal Year: 2010
    ..Our family studies indicate that: 1) both reproductive and metabolic abnormalities are heritable, 2) male as well as female ..
  57. Pancreas Volume in Preclinical Type 1 Diabetes
    Martha L Campbell-Thompson; Fiscal Year: 2013
    ..As well, monitoring pancreatic volume over time could function as an accurate, noninvasive, and simple surrogate marker for disease progression, allowing timely and guided clinical care. ..
  58. Natural History of Pre-diabetic Autoimmunity (DAISY)
    Marian J Rewers; Fiscal Year: 2013
    ..We will continue to make every effort to share DAISY resources with multiple investigators studying T1D and other autoimmune diseases, striving for an open-source database and repository. ..
  59. Influence of Psychosis on Brain-Behavior Endophenotypes for Bipolar Disorder
    David C Glahn; Fiscal Year: 2012
    ..This, in turn, should lead to improved characterization and treatment of bipolar disorder. ..
  60. Complement Genetics and Clinical Variability of Systemic Lupus Erythematosus
    CHACK Y YU; Fiscal Year: 2012
    ..the genotypic and phenotypic variations of C4A and C4B in European American patients with SLE, large number of family members and unrelated controls...
  61. Statistical Methods to Correct for Proxy Bias in Studies of Older Adults
    MICHELLE DENISE SHARDELL; Fiscal Year: 2013
    ..Trained investigators with expertise in both biostatistics and gerontology are urgently needed to solve problems in study design, outcome measurement, and statistics that are relevant to aging research. ..
  62. Gene Expression in Hippocampal Circuits of Bipolars and Schizophrenics
    Francine M Benes; Fiscal Year: 2011
    ....
  63. Integrating Patient Generated Family Health History from Varied EHR Entry Portals
    Jennifer S Haas; Fiscal Year: 2010
    ..Background: The long established wisdom of including family health history as a key part of an individual's medical record has been invigorated by the new emphasis on ..
  64. Health outcomes and improved phenotypic characterization of cleft lip and palate
    GEORGE WEHBY; Fiscal Year: 2009
    ..It is also anticipated that the health, social and economic outcomes of immediate family members may also be adversely affected...
  65. Genetic Linkage Analysis of Barrett's Esophagus
    Yvonne Romero; Fiscal Year: 2005
    ..To better assess the role of genetics in Barrett's esophagus, we have conducted: 1) Family studies that demonstrate a) Relatives of Barrett's probands have an over 2-fold increase in risk for Barrett's ..
  66. GENETIC EPIDEMIOLOGY--ALCOHOL ABUSE IN EATING DISORDERS
    Walter Kaye; Fiscal Year: 1993
    Alcohol abuse or dependency has been reported to occur frequently in patients with eating disorders and in their family members...
  67. ADRENERGIC VARIABLES: STATE MARKERS FOR PANIC DISORDER
    Oliver Cameron; Fiscal Year: 1990
    ..This study will advance our understanding of the possible etiologic significance of the physiological abnormalities associated with panic disorder...
  68. APPLYING GENOME MISMATCH SCANNING TO THE HUMAN GENOME
    Patrick Brown; Fiscal Year: 1999
    ..3. Only "affected" family members need to be analyzed for linkage mapping...
  69. ROCKY MOUNTAIN CANCER GENETICS COALITION
    Geraldine Mineau; Fiscal Year: 2006
    ..If so, they will be recontacted and asked to provide more detailed information regarding family history, as well as demographic and epidemiologic information...
  70. GENETIC STUDIES OF DEPRESSIVE DISORDERS
    Myrna Weissman; Fiscal Year: 2001
    ..completed blind interviews with over 700 of their first degree relatives ages 6 and older, and spouses; obtained family history data from multiple informants on over 1,600 first-degree relatives, and collected three or more ..
  71. Stability of Mexican-Origin Extended Family Households
    Jennifer Van Hook; Fiscal Year: 2005
    The overarching goal of the proposed research is to examine the formation and temporal stability of extended family households among Mexican immigrants and Mexican-origin natives...
  72. Antibodies to Recombinant Autoantigens: Prediction
    George Eisenbarth; Fiscal Year: 2004
    ....
  73. A Family-Genetic Study of Pathological Gambling
    Donald Black; Fiscal Year: 2009
    ..Despite its importance, there are no direct family interview studies of PG...