Genomes and Genes
Summary: A social group consisting of parents or parent substitutes and children.
Publications355 found, 100 shown here
- Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based studyPaul Lichtenstein
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Lancet 373:234-9. 2009..We aimed to assess genetic and environmental contributions to liability for schizophrenia, bipolar disorder, and their comorbidity...
- Effect of a family focused active play intervention on sedentary time and physical activity in preschool childrenMareesa V O'Dwyer
Early Childhood Ireland, Hainault House, Belgard Square, Tallaght, Dublin 24, Ireland
Int J Behav Nutr Phys Act 9:117. 2012..This study describes the effectiveness of a family-focused 'Active Play' intervention in decreasing sedentary time and increasing total physical activity in ..
- Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspectiveO J Bienvenu
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Psychol Med 42:1-13. 2012..The current study uses co-morbidity and familiality data to inform these issues...
- Randomised clinical trial of a family-based lifestyle intervention for childhood obesity involving parents as the exclusive agents of changeFelicity West
The University of Queensland, Brisbane, QLD, Australia
Behav Res Ther 48:1170-9. 2010..and confidence in managing children's dietary and activity patterns, and in promoting a healthy lifestyle in their family. However, few studies assess changes in parenting over the course of treatment...
- Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studiesA Antoniou
Cancer Research U K Genetic Epidemiology Unit, Department of Public Health, University of Cambridge, Cambridge, United Kingdom
Am J Hum Genet 72:1117-30. 2003..higher risk and/or other familial risk factors, whereas risk estimates from studies based on cases unselected for family history have been imprecise...
- Rare variant analysis for family-based designGourab De
Department of Biostatistics, Harvard University, Boston, MA, USA
PLoS ONE 8:e48495. 2013..Here we propose a novel method to test for association of rare variants obtained by sequencing in family-based samples by collapsing the standard family-based association test (FBAT) statistic over a region of interest...
- A unique library of myogenic cells from facioscapulohumeral muscular dystrophy subjects and unaffected relatives: family, disease and cell functionSachiko Homma
Neuromuscular Biology and Disease Group, Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
Eur J Hum Genet 20:404-10. 2012..We used this new collection to determine how family background and disease affected patterns of growth and differentiation, expression of a panel of candidate, and ..
- Giardiasis among different tribes of Orang Asli in Malaysia: highlighting the presence of other family members infected with Giardia intestinalis as a main risk factorTengku Shahrul Anuar
Department of Parasitology and Medical Entomology, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
Int J Parasitol 42:871-80. 2012..being a child aged less than 15 years, being male, the consumption of raw vegetables and the presence of other family members infected with G. intestinalis were the main risk factors for giardiasis...
- Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS familyAdam L Boxer
UCSF Memory and Aging Center, University of California San Francisco, CA 94143, USA
J Neurol Neurosurg Psychiatry 82:196-203. 2011..Previous studies have identified a region on chromosome 9p that is associated with FTD and ALS...
- Nurse-coordinated multidisciplinary, family-based cardiovascular disease prevention programme (EUROACTION) for patients with coronary heart disease and asymptomatic individuals at high risk of cardiovascular disease: a paired, cluster-randomised controlleD A Wood
Department of Cardiovascular Medicine, National Heart and Lung Institute at Charing Cross Campus, Imperial College, London, UK
Lancet 371:1999-2012. 2008Our aim was to investigate whether a nurse-coordinated multidisciplinary, family-based preventive cardiology programme could improve standards of preventive care in routine clinical practice.
- Family-centred approaches to the prevention of mother to child transmission of HIVTheresa S Betancourt
Francois Xavier Bagnoud Center for Health and Human Rights, Harvard School of Public Health, Harvard University, USA
J Int AIDS Soc 13:S2. 2010..narrow in scope, targeting biomedical interventions during the perinatal period, rather than considering HIV as a family disease...
- Risky families: family social environments and the mental and physical health of offspringRena L Repetti
Department of Psychology, University of California, Los Angeles, 90095 1563, USA
Psychol Bull 128:330-66. 2002..These family characteristics create vulnerabilities and/or interact with genetically based vulnerabilities in offspring that ..
- Mapping autism risk loci using genetic linkage and chromosomal rearrangementsPeter Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
Nat Genet 39:319-28. 2007..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
- Mutation analysis of CRYAA, CRYGC, and CRYGD associated with autosomal dominant congenital cataract in Brazilian familiesAlessandro Santana
Cataract Service, Department of Ophthalmology, Faculty of Medical Sciences, Irmandade da Santa Casa de Misericordia de Sao Paulo, Sao Paulo, Brazil
Mol Vis 15:793-800. 2009..The purpose of this study was to investigate mutations in alphaA-crystallin (CRYAA), gammaC-crystallin (CRYGC), and gammaD-crystallin (CRYGD) in Brazilian families with nuclear and lamellar autosomal dominant congenital cataract...
- Family perspectives on end-of-life care at the last place of careJoan M Teno
Center for Gerontology and Health Care Research, Brown Medical School, Providence, RI, USA
JAMA 291:88-93. 2004..Over the past century, nursing homes and hospitals increasingly have become the site of death, yet no national studies have examined the adequacy or quality of end-of-life care in institutional settings compared with deaths at home...
- Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disordersRichard J L Anney
Autism Genetics Group, Department of Psychiatry, Trinity College Dublin, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James Hospital, Dublin, Ireland
Eur J Hum Genet 19:1082-9. 2011..Both genes and processes that show enrichment have previously been examined in autistic disorders and offer biologically plausibility to these findings...
- Prevalence and characteristics of a family history of end-stage renal disease among adults in the United States population: Reasons for Geographic and Racial Differences in Stroke (REGARDS) renal cohort studyWilliam McClellan
Georgia Medical Care Foundation, Emory University, Suite 200, Executive Park South NE, Atlanta, GA 30329 2224, USA
J Am Soc Nephrol 18:1344-52. 2007This report describes the prevalence and characteristics of people with a family history of ESRD in a first-degree relative (FH-ESRD)...
- Suicide risk in relation to socioeconomic, demographic, psychiatric, and familial factors: a national register-based study of all suicides in Denmark, 1981-1997Ping Qin
National Center for Register based Research, Aarhus University, Denmark
Am J Psychiatry 160:765-72. 2003Suicide risk was addressed in relation to the joint effect of factors regarding family structure, socioeconomics, demographics, mental illness, and family history of suicide and mental illness, as well as gender differences in risk factors...
- Family-based association analysis to finemap bipolar linkage peak on chromosome 8q24 using 2,500 genotyped SNPs and 15,000 imputed SNPsPeng Zhang
Center for Computational Medicine and Bioinformatics Center for Statistical Genetics, Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
Bipolar Disord 12:786-92. 2010..We performed a detailed association analysis assessing the contribution of common genetic variation in this region to the risk of BP...
- A review of family and social determinants of children's eating patterns and diet qualityHeather Patrick
Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
J Am Coll Nutr 24:83-92. 2005With the growing problem of childhood obesity, recent research has begun to focus on family and social influences on children's eating patterns...
- Feeding the family during times of stress: experience and determinants of food insecurity in an Inuit communityJames D Ford
McGill University, Montreal, Quebec
Geogr J 177:44-61. 2011....
- The role of parental motivation in family-based treatment for childhood obesityThrudur Gunnarsdottir
University of Iceland, Centre of Public Health, Reykjavik, Iceland
Obesity (Silver Spring) 19:1654-62. 2011..the role of parental motivation (importance, confidence and readiness) for predicting dropout and outcome from family-based behavioral treatment for childhood obesity...
- Rare variant detection using family-based sequencing analysisGang Peng
Department of Bioinformatics and Computational Biology, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 110:3985-90. 2013..Our method (Family-Based Sequencing Program, FamSeq) integrates Mendelian transmission information and raw sequencing reads...
- Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2Mary Claire King
Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA
Science 302:643-6. 2003..We selected 1008 index cases, regardless of family history of cancer, and carried out molecular analysis across entire families...
- Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of leber hereditary optic neuropathy in Chinese families with the m.11778G-->a mutationYanli Ji
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
Am J Hum Genet 83:760-8. 2008..These findings will assist in further understanding the pathogenesis of LHON and guide future genetic counseling in East Asian patients with m.11778G-->A...
- Alcohol consumption and health status of family members: health impacts without ingestionW Liang
National Drug Research Institute, Curtin University, Perth, Western Australia, Australia
Intern Med J 43:1012-6. 2013..It was very difficult to separate the hypothesised physiological protective effect of moderate drinking from its well-correlated confounders in observational study settings...
- Elevation of fatty acid-binding protein 4 is predisposed by family history of hypertension and contributes to blood pressure elevationHideki Ota
Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
Am J Hypertens 25:1124-30. 2012..Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, and atherosclerosis. However, little is known about the role of FABP4 in essential hypertension...
- Familial aggregation of physical activity levels in the Québec Family StudyRiita L Simonen
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Med Sci Sports Exerc 34:1137-42. 2002Familial aggregation of physical activity phenotypes was investigated in 696 subjects from 200 families of the Quebec Family Study. The mean age of offspring and parents was 27 and 53 yr, respectively.
- Association of the type 2 diabetes mellitus susceptibility gene, TCF7L2, with schizophrenia in an Arab-Israeli family sampleAnna Alkelai
Biological Psychiatry Laboratory, Dept of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
PLoS ONE 7:e29228. 2012..Further validation studies in additional populations are required...
- The impact of dental caries and trauma in children on family quality of lifeJenny Abanto
Department of Pediatric Dentistry and Orthodontics, Dental School, University of Sao Paulo USP, Sao Paulo, SP, Brazil
Community Dent Oral Epidemiol 40:323-31. 2012To assess the impact of children's dental caries (DC) and traumatic dental injuries (TDI) on parents' quality of life (QoL), adjusted by family income.
- Fatal family outbreak of Bacillus cereus-associated food poisoningKatelijne Dierick
Institute of Public Health, Food Section, 14 Juliette Wijtsman Str, B 1050 Brussels, Belgium
J Clin Microbiol 43:4277-9. 2005..A fatal case due to liver failure after the consumption of pasta salad is described and demonstrates the possible severity of the emetic syndrome...
- In search of triallelism in Bardet-Biedl syndromeLeen Abu-Safieh
Developmental Genetics Unit, Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Eur J Hum Genet 20:420-7. 2012..In no instance did we observe two mutations in unaffected members of a given family, or observe the presence of a third allele that convincingly acted as a modifier of penetrance and supported the ..
- Novel mutation in GLRB in a large family with hereditary hyperekplexiaM Al-Owain
Department of Medical Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Clin Genet 81:479-84. 2012..This study presents a large family with HH as a result of homozygous mutation in GLRB and expands the clinical spectrum of HH to include eye ..
- Economic impact of dengue fever/dengue hemorrhagic fever in Thailand at the family and population levelsDanielle V Clark
Department of Virology, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 72:786-91. 2005..of hospitalization, indirect costs due to loss of productivity, and the average number of persons infected per family, we observed a financial loss of approximately US$61 per family, which is more than the average monthly income in ..
- On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association testIuliana Ionita-Laza
Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts, USA
Genet Epidemiol 32:273-84. 2008..In this paper, we propose a generalization of family-based association tests (FBATs) to allow for the analysis of CNVs at a genome-wide level...
- Family pet ownership during childhood: findings from a UK birth cohort and implications for public health researchCarri Westgarth
School of Veterinary Science, Faculty of Health and Life Sciences, University of Liverpool, Leahurst Campus, Neston, Cheshire, CH64 7TE, UK
Int J Environ Res Public Health 7:3704-29. 2010..Logistic regression was used to build multivariable models for ownership of each pet type at age 7 years. Family pet ownership increased during childhood, in particular rabbits, rodents and fish...
- Family reactions during infants' hospitalization in the neonatal intensive care unitMichael L Spear
Section of Neonatology, Department of Pediatrics, Christiana Care Health Services, Newark, Delaware, USA
Am J Perinatol 19:205-13. 2002The purpose of this investigation is to assess family stress, coping, perceptions of their infant, and alterations in mood that may result from the hospitalization of their critically ill newborn infant...
- Stigma and expressed emotion: a study of people with schizophrenia and their family members in ChinaMichael R Phillips
Beijing Hui Long Guan Hospital, China
Br J Psychiatry 181:488-93. 2002..The most damaging effect of stigma is the internalisation of others' negative valuations...
- Archetypal trajectories of social, psychological, and spiritual wellbeing and distress in family care givers of patients with lung cancer: secondary analysis of serial qualitative interviewsScott A Murray
Primary Palliative Care Research Group, Centre for Population Health Sciences General Practice Section, University of Edinburgh, Edinburgh EH8 9DX
BMJ 340:c2581. 2010To assess if family care givers of patients with lung cancer experience the patterns of social, psychological, and spiritual wellbeing and distress typical of the patient, from diagnosis to death.
- Unemployment and mental health: understanding the interactions among gender, family roles, and social classLucia Artazcoz
Department of Experimental Sciences and Health, Universitat Pompeu Fabra, and the Agència de Salut Pública de Barcelona, Barcelona, Spain
Am J Public Health 94:82-8. 2004We examined gender differences in the effects of unemployment on mental health and assessed whether such effects are associated with interactions among gender, family roles, and social class.
- Predictors of family risk for celiac disease: a population-based studyAlberto Rubio-Tapia
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Gastroenterol Hepatol 6:983-7. 2008There is an elevated prevalence of celiac disease (CD) in family members (FMs) of CD patients, but most prior studies have been done on selected populations...
- Family correlates of breakfast consumption among children and adolescents. A systematic reviewNatalie Pearson
School of Sport and Exercise Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, United Kingdom
Appetite 52:1-7. 2009..The family environment is an important influence on the dietary behaviours of young people, and therefore we systematically ..
- Family-based designs for genome-wide association studiesJurg Ott
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 4A Datun Road, Chaoyang District, Beijing 100101, China
Nat Rev Genet 12:465-74. 2011..b>Family designs allow for control of population stratification, investigations of questions such as parent-of-origin ..
- The experience of cancer cachexia: a qualitative study of advanced cancer patients and their family membersJoanne Reid
Unit of Nursing and Midwifery Research, Queen s University Belfast Belfast Health and Social Care Trust, Lisburn Road, Belfast, UK
Int J Nurs Stud 46:606-16. 2009..In spite of advances in understanding the biomedical aspects of cancer cachexia, little attention has been paid to exploring its holistic impact on patients and those who care for them...
- Quality indicators of end-of-life cancer care from the bereaved family members' perspective in JapanMitsunori Miyashita
Department of Adult Nursing Palliative Care Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Pain Symptom Manage 37:1019-26. 2009..several studies about quality indicators (QIs) in end-of-life (EOL) cancer care have been conducted, the bereaved family members' perspective of QIs has not been investigated in Japan...
- Recruitment and retention of participants in prevention trials involving family-based interventionsR J Prinz
Department of Psychology, University of South Carolina Prinz, Smith, Laughlin, White, Barron, Columbia, South Carolina 29208, USA
Am J Prev Med 20:31-7. 2001b>Family-based preventive intervention trials in the area of child conduct problems face serious challenges regarding the recruitment and subsequent retention of participants...
- Are family meal patterns associated with disordered eating behaviors among adolescents?Dianne Neumark-Sztainer
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
J Adolesc Health 35:350-9. 2004To examine associations between family meal patterns (frequency, priority, atmosphere, and structure of family meals) and disordered eating (unhealthy weight control behaviors, binge eating, and chronic dieting) in adolescent girls and ..
- A family with autosomal dominant leukodystrophy linked to 5q23.2-q23.3 without lamin B1 mutationsA Brussino
Department of Genetics, Biology and Biochemistry, University of Torino, and SCDU Medical Genetics, AOU San Giovanni Battista, Torino, Italy
Eur J Neurol 17:541-9. 2010..In a large Italian family, we recently identified a variant form of ADLD characterized clinically by absence of the autonomic dysfunction at ..
- Population-based screening for family history of end-stage renal disease among incident dialysis patientsBarry I Freedman
Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
Am J Nephrol 25:529-35. 2005....
- Impact of community-acquired paediatric rotavirus gastroenteritis on family life: data from the REVEAL studyMarie Van der Wielen
The Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Belgium
BMC Fam Pract 11:22. 2010..Although the epidemiology of rotavirus gastroenteritis (RVGE) is well documented, there are few data on the impact of RVGE on the families of affected children...
- Family nutritional support improves survival, immune restoration and adherence in HIV patients receiving ART in developing countryCharlotte Serrano
HIV Hepatitis Department, Sainte Marguerite Hospital APHM, Marseille, France
Asia Pac J Clin Nutr 19:68-75. 2010..This evaluation program estimated the impact of family nutritional support during the first year of antiretroviral treatment in West Africa's sub-Sahara region...
- Physically active families - de-bunking the myth? A qualitative study of family participation in physical activityJanice L Thompson
Department of Exercise, Nutrition and Health Sciences, University of Bristol, Bristol, UK
Child Care Health Dev 36:265-74. 2010..The need for more family-based interventions to increase physical activity is frequently cited in the literature; however, little is known ..
- BRCA1 and BRCA2 germline mutations in Malaysian women with early-onset breast cancer without a family historyGaik Theng Toh
Cancer Research Initiatives Foundation CARIF, Outpatient Centre, Subang Jaya Medical Centre, Selangor, Malaysia
PLoS ONE 3:e2024. 2008..A proportion of these cases may be attributable, at least in part, to genetic components, but to date, the contribution of genetic components to breast cancer in many of Malaysia's ethnic groups has not been well-characterised...
- Family impact of child oral and oro-facial conditionsDavid Locker
Community Dental Health Services Research Unit, Faculty of Dentistry, University of Toronto, Toronto, Canada
Community Dent Oral Epidemiol 30:438-48. 2002The aim of this study was to develop and evaluate the Family Impact Scale, a measure of the family impact of child oral and oro-facial disorders. This formed one component of the Child Oral Health Quality of Life Instrument.
- Family and child-care provider influences on preschool children's fruit, juice, and vegetable consumptionT A Nicklas
Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
Nutr Rev 59:224-35. 2001..Much remains to be learned about how these influences and practices affect the development of FJV preferences and consumption early in life...
- Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family RegistryElizabeth T Jacobs
Arizona Cancer Center, University of Arizona, Tucson, USA
Carcinogenesis 31:1412-6. 2010..overall and by colorectal subsite and microsatellite instability (MSI) status using data from the Colon Cancer Family Registry. No gene-level relationships between RXRA or CASR and colorectal cancer overall were observed...
- Are extended twin family designs worth the trouble? A comparison of the bias, precision, and accuracy of parameters estimated in four twin family modelsMatthew C Keller
Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA
Behav Genet 40:377-93. 2010..By modeling observed covariances of twins' relatives in addition to twins themselves, extended twin family designs (ETFDs) require less stringent assumptions, can estimate many more parameters of interest, and should ..
- Confirmation of family cancer history reported in a population-based surveyPhuong L Mai
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7022, Rockville Pike, Bethesda, MD 20852, USA
J Natl Cancer Inst 103:788-97. 2011Knowledge of family cancer history is essential for estimating an individual's cancer risk and making clinical recommendations regarding screening and referral to a specialty cancer genetics clinic...
- Factors considered important at the end of life by patients, family, physicians, and other care providersK E Steinhauser
Veterans Affairs Medical Center 152, 508 Fulton St, Durham, NC 27705, USA
JAMA 284:2476-82. 2000..Empirical evidence defining such factors, however, is lacking...
- Predictors of HIV-1 serostatus disclosure: a prospective study among HIV-infected pregnant women in Dar es Salaam, TanzaniaG Antelman
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
AIDS 15:1865-74. 2001..Lack of disclosure may have limited their ability to engage in preventive behaviors or to obtain the necessary emotional support for coping with their serostatus or illness...
- Family caregivers' subjective experiences of satisfaction in dementia care: aspects of burden, subjective health and sense of coherenceSigne Andrén
Division of Geriatric Medicine, Department of Community Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
Scand J Caring Sci 19:157-68. 2005b>Family caregivers experience both positive and negative reactions in caregiving situations. There has been considerably less published about the positive aspects, however...
- A Chinese family with progressive childhood cataracts and IVS3+1G>A CRYBA3/A1 mutationsYanan Zhu
Eye Center of the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
Mol Vis 16:2347-53. 2010To characterize the disease-causing mutations in a Chinese family with progressive childhood cataracts.
- A novel mutation in the major intrinsic protein (MIP) associated with autosomal dominant congenital cataracts in a Chinese familyWei Wang
Eye Center of the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
Mol Vis 16:534-9. 2010To detect the underlying genetic defect in a Chinese family affected with bilateral congenital cataracts.
- Circulating 25OHD, dietary vitamin D, PTH, and calcium associations with incident cardiovascular disease and mortality: the MIDSPAN Family StudyPaul Welsh
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom
J Clin Endocrinol Metab 97:4578-87. 2012..Observational studies relating circulating 25-hydroxyvitamin D (25OHD) and dietary vitamin D intake to cardiovascular disease (CVD) have reported conflicting results...
- Neurocognition in youth and young adults under age 30 at familial risk for schizophrenia: a quantitative and qualitative reviewJessica Agnew-Blais
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Cogn Neuropsychiatry 18:44-82. 2013..Studying nonpsychotic relatives ("familial high-risk", or FHR) allows for identification of cognitive vulnerability markers independent of confounds associated with psychosis...
- A novel missense SNRNP200 mutation associated with autosomal dominant retinitis pigmentosa in a Chinese familyTiecheng Liu
Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China
PLoS ONE 7:e45464. 2012..In this work, we analyzed a Chinese family with adRP and identified a novel missense mutation in SNRNP200...
- The impact of midlife educational, work, health, and family experiences on men's early retirementMarleen Damman
Netherlands Interdisciplinary Demographic Institute, P O Box 11650, 2502 AR The Hague, The Netherlands
J Gerontol B Psychol Sci Soc Sci 66:617-27. 2011..aims to improve our understanding of retirement by examining the impact of midlife educational, work, health, and family experiences on early retirement intentions and behavior...
- Family-related predictors of body weight and weight-related behaviours among children and adolescents: a systematic umbrella reviewA Cislak
Warsaw School of Social Sciences and Humanities, Warsaw, Poland
Child Care Health Dev 38:321-31. 2012This umbrella review analysed the relationships between family variables and child/adolescent body weight, diet and physical activity...
- Family burden in long-term diseases: a comparative study in schizophrenia vs. physical disordersLorenza Magliano
Department of Psychiatry, University of Naples, Largo Madonna delle Grazie, I 80138 Naples, Italy
Soc Sci Med 61:313-22. 2005..Each relative was asked to fill in the Family Problems Questionnaire (FPQ) and the Social Network Questionnaire (SNQ)...
- Nursing home placement: an exploration of the experiences of family carersA A Ryan
University of Ulster, Coleraine, Co Londonderry, Northern Ireland
J Adv Nurs 32:1187-95. 2000This study examines some of the factors leading family carers to place their older relatives in a nursing home. It also explores their thoughts and feelings about their relatives' admission to a nursing home...
- Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and case-control studiesYelena Bykhovskaya
Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Division of Surgical Research, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Invest Ophthalmol Vis Sci 53:4152-7. 2012..To determine whether LOX is a genetic determinant of the pathogenesis of keratoconus, we analyzed association results of LOX polymorphisms in two independent case-control samples and in keratoconus families...
- The role of the family and improvement in treatment maintenance, adherence, and outcome for schizophreniaIra D Glick
Psychiatry and Behavioral Sciences, Schizophrenia Research Program, Stanford University School of Medicine, Stanford, CA, USA
J Clin Psychopharmacol 31:82-5. 2011..study evaluating the relative effectiveness and safety of antipsychotic medication (CATIE), we examined the relationship between treatment outcome and 2 family variables: their presence and their ability to support treatment adherence.
- Arrhythmogenic right ventricular dysplasia/cardiomyopathy: pathogenic desmosome mutations in index-patients predict outcome of family screening: Dutch arrhythmogenic right ventricular dysplasia/cardiomyopathy genotype-phenotype follow-up studyMoniek G P J Cox
Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
Circulation 123:2690-700. 2011..Previous genotype-phenotype relation studies involved mainly overt ARVD/C index patients, so follow-up data on relatives are scarce...
- A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activityH Lavretsky
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
Int J Geriatr Psychiatry 28:57-65. 2013This study examined the effects of brief daily yogic meditation on mental health, cognitive functioning, and immune cell telomerase activity in family dementia caregivers with mild depressive symptoms.
- Broader autism phenotype: evidence from a family history study of multiple-incidence autism familiesJ Piven
Department of Psychiatry, University of Iowa College of Medicine, Iowa City, USA
Am J Psychiatry 154:185-90. 1997..The objective of this study was to examine behaviors that may define this broader phenotype in relatives ascertained through two autistic siblings...
- Women's higher likelihood of disability pension: the role of health, family and work. A 5-7 years follow-up of the Hordaland Health StudyInger Haukenes
Department of Public Health and Primary Health Care, University of Bergen, Kalfarveien 31, NO 5018, Bergen, Norway
BMC Public Health 12:720. 2012..The aim of the study was to examine the extent to which self-perceived health, family situation and work factors explain women's higher risk of disability pension...
- Mastery, burden, and areas of concern among family caregivers of mentally ill personsLinda E Rose
The Johns Hopkins University, School of Nursing, Baltimore, MD 21205, USA
Arch Psychiatr Nurs 20:41-51. 2006In an era of limited resources for mental health care, family interventions need to target areas where they are responsive to families' expressed needs...
- The accuracy of surrogate decision makers: a systematic reviewDavid I Shalowitz
Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20892, USA
Arch Intern Med 166:493-7. 2006..However, commentators have questioned the accuracy with which surrogates predict patients' treatment preferences...
- Parenting styles, family structure and adolescent dietary behaviourNatalie Pearson
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK
Public Health Nutr 13:1245-53. 2010To examine associations between parenting styles, family structure and aspects of adolescent dietary behaviour.
- Familial identification: population structure and relationship distinguishabilityRori V Rohlfs
Department of Integrative Biology, University of California Berkeley, Berkeley, California, USA
PLoS Genet 8:e1002469. 2012..Implementation of familial searching has been proposed to extend forensic identification to family members of individuals with profiles in offender/arrestee DNA databases...
- The Virtual Family--development of surface-based anatomical models of two adults and two children for dosimetric simulationsAndreas Christ
Foundation for Research on Information Technologies in Society, Zeughausstr 43, 8004 Zurich, Switzerland
Phys Med Biol 55:N23-38. 2010..These four models are referred to as the Virtual Family. They are based on high resolution magnetic resonance (MR) images of healthy volunteers...
- Stress, social support, and HIV-status disclosure to family and friends among HIV-positive men and womenSeth C Kalichman
Center for AIDS Intervention Research Medical College of Wisconsin, Milwaukee, Wisconsin, USA
J Behav Med 26:315-32. 2003..Structured interviews assessed HIV-status disclosure to family and friends, perceived stress of disclosure, social support, and depression...
- Family support and family-centered care in the neonatal intensive care unit: origins, advances, impactJudith S Gooding
NICU Initiatives and Chapter Program Strategy, Chapter Program Support, March of Dimes Foundation, White Plains, NY 10605, USA
Semin Perinatol 35:20-8. 2011b>Family-centered care (FCC) has been increasingly emphasized as an important and necessary element of neonatal intensive care...
- Forensic utilization of familial searches in DNA databasesCassandra J Gershaw
John Jay College of Criminal Justice, North Hall, New York, NY 10019, USA
Forensic Sci Int Genet 5:16-20. 2011..This article discusses prospective positive outcomes of utilizing familial DNA searches and acknowledges potential negative outcomes, thereby presenting both sides of this very complicated, rapidly evolving situation...
- The endophenotype concept in psychiatry: etymology and strategic intentionsIrving I Gottesman
Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55454, USA
Am J Psychiatry 160:636-45. 2003..The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics...
- Genomic identification in the historical case of the Nicholas II royal familyEvgeny I Rogaev
Department of Genomics and Laboratory of Evolutionary Genomics, Vavilov Institute of General Genetics, Russian Academy of Science, Gubkina Street, 3, Moscow, 119991, Russian Federation
Proc Natl Acad Sci U S A 106:5258-63. 2009..The controversy surrounding the fate of the last Russian Emperor, Nicholas II, and his family has persisted, in part, because the bodies of 2 children, Prince Alexei and 1 of his sisters, have not been found...
- Family communication about positive BRCA1 and BRCA2 genetic test resultsBobbi McGivern
Clinical Cancer Genetics, MD Anderson Cancer Center, Houston, Texas, USA
Genet Med 6:503-9. 2004..information to individuals who receive this result, but it can also provide crucial cancer risk information to family members. Most of the research on communication of genetic test results has focused on first degree relatives...
- Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholismXing Dai
Douglas Hospital Research Centre and the Department of Psychiatry, McGill University, Montreal, Quebec, Canada
Alcohol Clin Exp Res 29:1965-75. 2005..The objective of the present studies was to test the hypothesis that there are differences in the response of the pituitary beta-endorphin system to stress as a function of family history of alcoholism and alcohol dependence.
- Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescenceGregory E Miller
University of British Columbia, 2136 W Mall Ave, Vancouver, British Columbia, Canada V6T 1Z4
Psychol Sci 21:848-56. 2010..If sustained, these tendencies may place children from harsh families on a developmental trajectory toward the chronic diseases of aging...
- Molecular genetics of attention-deficit/hyperactivity disorderStephen V Faraone
Medical Genetics Research Center and Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
Biol Psychiatry 57:1313-23. 2005..We review this literature, with a particular emphasis on molecular genetic studies. Family, twin, and adoption studies provide compelling evidence that genes play a strong role in mediating susceptibility ..
- Large novel deletions detected in Chinese families with aniridia: correlation between genotype and phenotypeXiaohui Zhang
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
Mol Vis 17:548-57. 2011..To describe the clinical and genetic findings in two Chinese families with aniridia and other ocular abnormalities...
- Association of DRD2 variants and Gilles de la Tourette syndrome in a family-based sample from a South American population isolateIbi Herzberg
Research Department of Genetics, Evolution and Environment, University College London
Psychiatr Genet 20:179-83. 2010..Our findings replicate the association of DRD2 and GTS, and are consistent with the proposed connection between the dopamine system and this complex neuropsychiatric disease...
- Review of the literature on the effects of caring for a patient with cancerUna Stenberg
Center for Shared Decision Making and Nursing Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Psychooncology 19:1013-25. 2010To adequately help family caregivers (FCs) of cancer patients, clinicians need to understand the complexity of the problems and responsibilities associated with cancer patients illness that FCs experience.
- Family members' perceived needs for bereavement follow-upAnna Milberg
Department of Social and Welfare Studies, Linkoping University, Linkoping, Sweden
J Pain Symptom Manage 35:58-69. 2008..The study design was cross-sectional and targeted family members three to nine months after the patient's death...
- Kin recognition signals in adult facesLisa M DeBruine
School of Psychology, University of Aberdeen, Aberdeen AB24 2UB, UK
Vision Res 49:38-43. 2009..Using adult sibling faces, we find that similarity ratings for same-sex pairs were significantly higher than for opposite-sex pairs, suggesting that similarity judgments of adult faces are not entirely synonymous with kinship judgments...
- Family member satisfaction with end-of-life decision making in the ICUCynthia J Gries
Division of Pulmonary and Critical Care, Department of Medicine, University of Washington, Seattle, WA 98195, USA
Chest 133:704-12. 2008..The identification of chart-based quality indicators of palliative care that predict family satisfaction with decision making may help to guide interventions to improve decision making and family outcomes.
- Socio-economic impact of tuberculosis on patients and family in IndiaR Rajeswari
Tuberculosis Research Centre, Indian Council of Medical Research, Chetput, Chennai, India
Int J Tuberc Lung Dis 3:869-77. 1999..To quantify the socio-economic impact of tuberculosis on patients and their families from the costs incurred by patients in rural and urban areas...
- Individual, family, and neighborhood factors distinguish resilient from non-resilient maltreated children: a cumulative stressors modelSara R Jaffee
Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
Child Abuse Negl 31:231-53. 2007..Which individual, family, and neighborhood characteristics distinguish resilient from non-resilient maltreated children? Do children's ..
- Family health care decision making and self-efficacy with patients with ALS at the end of lifeMarie T Nolan
School of Nursing, Berman Institute of Bioethics, Johns Hopkins University, Baltimore, Maryland 21205, USA
Palliat Support Care 6:273-80. 2008..This study compared the preferences of patients with ALS for involving family in health care decisions at the end of life with the actual involvement reported by the family after death.
- Impact of colorectal cancer on patient and family: implications for careHortense Cotrim
Department of Nursing, Health School Egas Moniz, Instituto Superior de saude Egas Moniz, Caparica, Portugal
Eur J Oncol Nurs 12:217-26. 2008The quality of life of a colorectal cancer patient and his family is deeply modified when faced with this diagnosis as a result of physical and psychological changes induced by it...
- Loneliness, social support and family function of people living with HIV/AIDS in Anhui rural area, ChinaY H Sun
Department of Epidemiology and Statistics, School of Public Health, Anhui Medical University, Hefei 230032, China
Int J STD AIDS 20:255-8. 2009The main purpose of this study was to investigate how loneliness was associated with social support and family function among people living with HIV/AIDS (PLWHA) in an HIV-stricken area of China...
- REGULATION AND FUNCTION OF STE20-RELATED PROTEIN KINASESMelanie H Cobb; Fiscal Year: 2012..WNK1 is essential for embryonic development in mice. The best known function of WNK family members is their influence on ion balance...
- Cellular &Molecular Defects in Human B Cell DevelopmentCharlotte Cunningham-Rundles; Fiscal Year: 2013..We hypothesize that mutations in this receptor and its isoforms can be used to elucidate the complex functions of this receptor in a human system. ..
- THE ETHICS OF POST-CONFLICT AND POST-DISASTER DNA IDENTIFICATIONSarah Wagner; Fiscal Year: 2013..Finally, the research team will publish a collection of oral histories documenting the family and community perspective on missing persons in a book series for lay readers called Voice of Witness...
- AAA ATPases linking mitochondria with microtubule processing in flies and yeastKaren G Hales; Fiscal Year: 2012..Since various observations initially suggest a conserved role for Nmd family members in both mitochondrial shaping and microtubule processing, the primary emphasis in the proposed research is ..
- Celiac Disease: From Genetic Risk to Disease DevelopmentSusan L Neuhausen; Fiscal Year: 2009..to a gluten-free diet? To investigate these questions, we will recontact individuals previously enrolled in two family studies, one at the University of California Irvine and one at Mayo Clinic, in which we had systematically ..
- Novel Catalases and their ProductsAlan R Brash; Fiscal Year: 2013..will provide new insights and a new way of thinking about the enzymatic capabilities of a long-recognized protein family with established roles as a sentinel at the forefront of oxidative defense...
- Evolutionary Analysis of the Histone Deacetylase Family: Biomedical ResearchJOSEPH LEWIS GRAVES; Fiscal Year: 2011..seeks to utilize evolutionary methods to examine molecular signatures of positive in the histone deacetylase family (HDAC's...
- Social Networks &Breast Cancer Prognosis in the Chinese and US Evaluation StudyCandyce H Kroenke; Fiscal Year: 2013..I we demonstrate these findings, family interventions previously employed to improve lifestyle factors in persons with cardiovascular conditions might ..
- DNA METHYLOME STUDY IN TYPE 1 DIABETESART PETRONIS; Fiscal Year: 2009..test germline samples of fathers who have children with T1D and are also affected with T1D themselves or have a family history of T1D...
- The Metabolic Impact of Congenital Heterozygous ApoC-III Deficiency in HumansTONI ILANA POLLIN; Fiscal Year: 2013..This project will look more closely at the effects of the deficiency on human metabolism to better understand the function of the apoC-III protein and its potential as a drug target. ..
- SGK Regulation of Epithelial Sodium TransportDavid Pearce; Fiscal Year: 2013..C) Examine the role of mTOR in regulation of amiloride-inhibitable currents in isolated CCD using patch clamp. ..
- Molecular probes for a vOTU from CCHFV using a fluorogenic peptideSCOTT DUSAN PEGAN; Fiscal Year: 2013....
- Phenotypic Spectrum of LRRK2 MutationsRachel Saunders-Pullman; Fiscal Year: 2013..As noted, this study will expand on a large Consortium study of a unique cohort of Ashkenazi Jews with PD, family members and controls, by adding measures and new analyses...
- MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATEJeffrey C Murray; Fiscal Year: 2013..Additional genotyping of the extended family members with subphenotyping will then better inform gene finding and phenotype correlations...
- Exploiting toxins to probe sensory signalingDavid Julius; Fiscal Year: 2012..With this in mind, we have recently discovered a novel family of peptide toxins from tarantula that activate the capsaicin receptor, TRPV1, to produce inflammatory pain (..
- RNA quality control and environmental stressSandra L Wolin; Fiscal Year: 2013....
- Structural Rearrangements in GABA-A ReceptorsCYNTHIA M CZAJKOWSKI; Fiscal Year: 2012....
- The Ecology, Emergence and Pandemic Potential of Nipah virus in BangladeshPeter Daszak; Fiscal Year: 2012..Our work will examine why this virus is emerging, and help provide an early warning system for Nipah virus in Bangladesh. It will also give us a better understanding of the likelihood of this and other pathogens becoming pandemic. ..
- Control of bacterial morphology and differentiationYves V Brun; Fiscal Year: 2013..Insights gained from these studies can be used to design strategies to inhibit growth, prevent key morphological changes, or alter important protein localization pathways in pathogens, thereby improving our ability to control them. ..
- Multigenerational FamIlial and Environmental Risk for Autism (MINERvA) NetworkAbraham Reichenberg; Fiscal Year: 2013DESCRIPTION (provided by applicant): Better understanding of the etiologic roles of family history, prenatal environmental factors, and potential biologic mechanisms, such as epigenetic changes, in autism spectrum disorders (ASD) are ..
- Environmental Determinants of Autoimmunity among African Americans in Coastal SCDiane L Kamen; Fiscal Year: 2012....
- Pre-BCR Function Selecting Novel B Cell Receptors in Chronic Lymphocytic LeukemiaKyoko Hayakawa; Fiscal Year: 2010....
- Identifying New Regulators of Leptin-Like Signaling in Drosophila Brain NeuronsKAI G ZINN; Fiscal Year: 2013..Negative regulators identified in these experiments might be potential drug targets whose inhibition could upregulate anorexigenic leptin signaling in leptin-resistant obese individuals. ..
- Clinical Risk Prediction Modeling in Rheumatoid ArthritisElizabeth W Karlson; Fiscal Year: 2013..prediction models to predict 5-year RA risk for all RA and for subsets defined by sex, immune phenotype, and family history: (a) an "environmental" model using behavioral factors, environmental exposures, and clinical factors , ..
- The Role of Plasmids in Rickettsia BiologyULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013..The results of this research may provide new tools to control Rickettsia infections of humans. ..
- Investigational Safety and Toxicity Studies of Subcutaneous COG1410 for AlzheimerMICHAEL PETER VITEK; Fiscal Year: 2013..or about 20% of their combined programs on the care of AD patients, as there is no effective treatment, and family caregivers spent at least $94 Billion more on caring for relatives with AD...
- Genetics of Parkinsonism in a Special Population of Untreated SchizophreniaGabriel Alejandro De Erausquin; Fiscal Year: 2013..Lastly, we anticipate that our research strategy may indicate new waysto study and address the increased vulnerability of schizophrenic patients to nicotine dependence. ..
- The Roles of Fat3 and Atrophin-2 in Jaw-Joint Development in ZebrafishPierre Le Pabic; Fiscal Year: 2013..Most of the techniques employed under this award will be learned by the candidate under the supervision of his sponsor, and will prepare him for a career as a Principal Investigator in the field of developmental biology. ..
- Evolution of Drosophila melanogaster cis-regulatory modulesAaron Hardin; Fiscal Year: 2013....
- Pathways from genotype and environment to melanomaNicholas K Hayward; Fiscal Year: 2012..We also have >4000 DNA samples from adolescent twins and their family members for whom we have nevus counts and pigmentary phenotypes...
- Virulence factor identification by comparative transcriptomics in Candida speciesMichael C Lorenz; Fiscal Year: 2013....
- Understanding early events in lupus autoimmunity to aid preventionJudith A James; Fiscal Year: 2013....
- Advanced Naturally Designed Channelrhodopsins for Photocontrol of Neural ActivityJOHN LEE SPUDICH; Fiscal Year: 2010....
- Genome-Wide Targeted Gene Resequencing in GlaucomaTHERESA GAASTERLAND; Fiscal Year: 2010....
- Genomics of Primary Biliary CirrhosisKonstantinos N Lazaridis; Fiscal Year: 2013..and outcomes, prospectively collected questionnaire data regarding life-styles, environmental exposures, and family history, as well as biospecimens including DNA, serum, plasma, and lymphoblastoid cell-lines (LCLs)...
- DEVELOPING PET AGENTS FOR IMAGING PHOSPHODIESTERASE 10A (PDE10A)Zhude Tu; Fiscal Year: 2012..A PET radiotracer of PDE10A may help physician to quantify the progression of Huntington Disease based on the PET measurement of PDE10A level in patients with the Huntington disease patients. ..
- Structural Studies and Char. of Neurotoxic Venom Peptides from Sicariidae SpidersNIKOLAUS MARTIN LOENING; Fiscal Year: 2012..In addition, some venom peptides are species-specific and therefore have the potential to be used as environmentally-friendly insecticidal toxins. ..
- Role of autoantibody isotype in pemphigus pathogenesisAimee S Payne; Fiscal Year: 2013..As similar isotype profiles occur in pemphigoid, epidermolysis bullosa acquisita, and other chronic autoimmune conditions, our studies may have therapeutic relevance for a broad range of autoantibody-mediated diseases. ..
- An iPS Disease-in-a-Dish Model of Familial AlzheimersTerrence Town; Fiscal Year: 2012..If successful, this exciting disease-in-a-dish model could allow pre-clinical testing of therapeutic approaches. ..
- RA-Related Autoantibodies in Healthy FDR of RA PatientsJill M Norris; Fiscal Year: 2011....
- Leveraging genetics and environment to predict presymptomatic multiple sclerosisZongqi Xia; Fiscal Year: 2013..that such an algorithm can provide MS risk stratification for asymptomatic subjects at risk of MS, such as family members or patients with Radiologically Isolated Syndrome (RIS: asymptomatic individuals with incidental findings ..
- Decision Making in Unaffected First-Degree Relatives of Prostate Cancer PatientsClement Gwede; Fiscal Year: 2009..the controversy, many men who are likely to develop prostate cancer including African American men and men with a family history of prostate cancer, remain uncertain about whether to take the PSA test or not to take the test;and often ..
- Disclosing Genomic Incidental Findings in a Cancer Biobank: An ELSI ExperimentSusan M Wolf; Fiscal Year: 2013..Working Group, we will conduct an experiment designed to develop strategies for offering incidental findings to family members of probands in a biobank for pancreatic cancer...
- Molecular characterization of novel loci for orofacial clefting using canine modeDanika L Bannasch; Fiscal Year: 2013..4 Mb each. By comparing genotypes of family members, both regions were shown to be inherited as independent simple recessive traits...
- Gene regulatory network evolution and the origin of biological noveltiesMARK MARTINDALE; Fiscal Year: 2013..These novel data will provide insight into the significance of variations in the GRNs in different systems and suggest specific gene interactions involved in abnormalities in endomesodermal development. ..
- Training in Neurogenetics: Function of NUP107 in Human and MouseBethany N Sotak; Fiscal Year: 2012..I have identified a new causative gene, NUP107, and propose to study induced-pluripotent stem cells and knockout mice to model this human disease. ..
- Penn Center for ELSI Research in Emerging Genetic Technologies in Health CareReed E Pyeritz; Fiscal Year: 2012..genetic makeup will lead to better health, improved treatments and a better understanding of risks to other family members...
- Genes contributing for nicotine dependence in humansKari Stefansson; Fiscal Year: 2013....
- CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISMKenneth Kidd; Fiscal Year: 2009..Indications of the importance to alcoholism of different genetic variants and of which haplotypes may harbor cryptic but functionally relevant variation will result from these studies. ..
- Adipocyte insulin signaling and circulating adiponectin levelsROCIO INES PEREIRA; Fiscal Year: 2010..The anticipated results of this clinical study may provide new insight into potential therapeutic targets in patients with T2DM, obesity, and MetS. ..
- Role of Neuropeptide S in age-related cognitive declineOlivier Civelli; Fiscal Year: 2012..The study is both exploratory and translational and could lead to a better understanding of neural mechanisms underlying cognitive aging. ..
- Prediction Model: Breast Cancer in Women Irradiated for a Pediatric MalignancyChaya Moskowitz; Fiscal Year: 2013..of radiation to the chest, other treatment-related factors, the traditional breast cancer risk factors such as family and reproductive histories, and other non-treatment related risk factors...
- Natural History of MYH9-Associated NephropathyBARRY IRA FREEDMAN; Fiscal Year: 2012..of this project are: (1) recruitment of 1,200 unrelated African American subjects at high risk for HN based upon family history of H-ESRD, with phenotyping for the presence of hypertension, kidney disease and kidney disease-risk ..
- Medical Consequences of Long-Term Anabolic-Androgenic Steroid AbuseHarrison G Pope; Fiscal Year: 2013DESCRIPTION (provided by applicant): The anabolic-androgenic steroids (AAS) are a family of hormones that includes testosterone and its synthetic derivatives...
- MRI and Neuropsychological Findings in Schizophrenia, ADHD and Healthy ControlsMARTHA ELIZABETH SHENTON; Fiscal Year: 2010..The proposed study will investigate important scientific topics relevant to global health, schizophrenia and ADHD, both of which cause significant burden on society globally. ..
- Metabolic Syndrome in PCOS: Precursors and InterventionsAndrea Dunaif; Fiscal Year: 2010..Our family studies indicate that: 1) both reproductive and metabolic abnormalities are heritable, 2) male as well as female ..
- Pancreas Volume in Preclinical Type 1 DiabetesMartha L Campbell-Thompson; Fiscal Year: 2013..As well, monitoring pancreatic volume over time could function as an accurate, noninvasive, and simple surrogate marker for disease progression, allowing timely and guided clinical care. ..
- Natural History of Pre-diabetic Autoimmunity (DAISY)Marian J Rewers; Fiscal Year: 2013..We will continue to make every effort to share DAISY resources with multiple investigators studying T1D and other autoimmune diseases, striving for an open-source database and repository. ..
- Influence of Psychosis on Brain-Behavior Endophenotypes for Bipolar DisorderDavid C Glahn; Fiscal Year: 2012..This, in turn, should lead to improved characterization and treatment of bipolar disorder. ..
- Complement Genetics and Clinical Variability of Systemic Lupus ErythematosusCHACK Y YU; Fiscal Year: 2012..the genotypic and phenotypic variations of C4A and C4B in European American patients with SLE, large number of family members and unrelated controls...
- Statistical Methods to Correct for Proxy Bias in Studies of Older AdultsMICHELLE DENISE SHARDELL; Fiscal Year: 2013..Trained investigators with expertise in both biostatistics and gerontology are urgently needed to solve problems in study design, outcome measurement, and statistics that are relevant to aging research. ..
- Gene Expression in Hippocampal Circuits of Bipolars and SchizophrenicsFrancine M Benes; Fiscal Year: 2011....
- Integrating Patient Generated Family Health History from Varied EHR Entry PortalsJennifer S Haas; Fiscal Year: 2010..Background: The long established wisdom of including family health history as a key part of an individual's medical record has been invigorated by the new emphasis on ..
- Health outcomes and improved phenotypic characterization of cleft lip and palateGEORGE WEHBY; Fiscal Year: 2009..It is also anticipated that the health, social and economic outcomes of immediate family members may also be adversely affected...
- Genetic Linkage Analysis of Barrett's EsophagusYvonne Romero; Fiscal Year: 2005..To better assess the role of genetics in Barrett's esophagus, we have conducted: 1) Family studies that demonstrate a) Relatives of Barrett's probands have an over 2-fold increase in risk for Barrett's ..
- GENETIC EPIDEMIOLOGY--ALCOHOL ABUSE IN EATING DISORDERSWalter Kaye; Fiscal Year: 1993Alcohol abuse or dependency has been reported to occur frequently in patients with eating disorders and in their family members...
- ADRENERGIC VARIABLES: STATE MARKERS FOR PANIC DISORDEROliver Cameron; Fiscal Year: 1990..This study will advance our understanding of the possible etiologic significance of the physiological abnormalities associated with panic disorder...
- APPLYING GENOME MISMATCH SCANNING TO THE HUMAN GENOMEPatrick Brown; Fiscal Year: 1999..3. Only "affected" family members need to be analyzed for linkage mapping...
- ROCKY MOUNTAIN CANCER GENETICS COALITIONGeraldine Mineau; Fiscal Year: 2006..If so, they will be recontacted and asked to provide more detailed information regarding family history, as well as demographic and epidemiologic information...
- GENETIC STUDIES OF DEPRESSIVE DISORDERSMyrna Weissman; Fiscal Year: 2001..completed blind interviews with over 700 of their first degree relatives ages 6 and older, and spouses; obtained family history data from multiple informants on over 1,600 first-degree relatives, and collected three or more ..
- Stability of Mexican-Origin Extended Family HouseholdsJennifer Van Hook; Fiscal Year: 2005The overarching goal of the proposed research is to examine the formation and temporal stability of extended family households among Mexican immigrants and Mexican-origin natives...
- Antibodies to Recombinant Autoantigens: PredictionGeorge Eisenbarth; Fiscal Year: 2004....
- A Family-Genetic Study of Pathological GamblingDonald Black; Fiscal Year: 2009..Despite its importance, there are no direct family interview studies of PG...