hallucinations

Summary

Summary: Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.

Top Publications

  1. pmc Auditory hallucinations in schizophrenia and nonschizophrenia populations: a review and integrated model of cognitive mechanisms
    Flavie Waters
    Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, North Metro Area Mental Health Perth, Australia
    Schizophr Bull 38:683-93. 2012
  2. pmc Neuroimaging auditory hallucinations in schizophrenia: from neuroanatomy to neurochemistry and beyond
    Paul Allen
    Department of Psychosis Studies, Institute of Psychiatry, King s College, DeCrespigny Park, London SE5 8AF, UK
    Schizophr Bull 38:695-703. 2012
  3. pmc Mobile Assessment and Treatment for Schizophrenia (MATS): a pilot trial of an interactive text-messaging intervention for medication adherence, socialization, and auditory hallucinations
    Eric Granholm
    Psychology Service, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Schizophr Bull 38:414-25. 2012
  4. ncbi The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years
    Mariese A Hely
    Department of Neurology, Westmead Hospital, Westmead, New South Wales, Australia
    Mov Disord 23:837-44. 2008
  5. pmc The characteristic features of auditory verbal hallucinations in clinical and nonclinical groups: state-of-the-art overview and future directions
    Frank Larøi
    Department of Psychology, FAPSE, University of Liege, 4000 Liege, Belgium
    Schizophr Bull 38:724-33. 2012
  6. ncbi Applying interpersonal theories to the understanding of and therapy for auditory hallucinations: a review of the literature and directions for further research
    Mark Hayward
    University of Sussex and Sussex Partnership NHS Foundation Trust, Nevill Avenue, Hove BN3 7HZ, UK
    Clin Psychol Rev 31:1313-23. 2011
  7. ncbi The role of social schema in the experience of auditory hallucinations: a systematic review and a proposal for the inclusion of social schema in a cognitive behavioural model of voice hearing
    Georgie Paulik
    School of Psychiatry, University of New South Wales, Australia
    Clin Psychol Psychother 19:459-72. 2012
  8. ncbi Cortical activations during auditory verbal hallucinations in schizophrenia: a coordinate-based meta-analysis
    Renaud Jardri
    CNRS, University Lille North of France, France
    Am J Psychiatry 168:73-81. 2011
  9. ncbi Structural correlates of auditory hallucinations in schizophrenia: a meta-analysis
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Schizophr Res 137:169-73. 2012
  10. ncbi How can the brain's resting state activity generate hallucinations? A 'resting state hypothesis' of auditory verbal hallucinations
    Georg Northoff
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research IMHR, 1145 Carling Avenue, Ottawa, ON K1Z 7K4, Canada
    Schizophr Res 127:202-14. 2011

Detail Information

Publications376 found, 100 shown here

  1. pmc Auditory hallucinations in schizophrenia and nonschizophrenia populations: a review and integrated model of cognitive mechanisms
    Flavie Waters
    Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, North Metro Area Mental Health Perth, Australia
    Schizophr Bull 38:683-93. 2012
    While the majority of cognitive studies on auditory hallucinations (AHs) have been conducted in schizophrenia (SZ), an increasing number of researchers are turning their attention to different clinical and nonclinical populations, often ..
  2. pmc Neuroimaging auditory hallucinations in schizophrenia: from neuroanatomy to neurochemistry and beyond
    Paul Allen
    Department of Psychosis Studies, Institute of Psychiatry, King s College, DeCrespigny Park, London SE5 8AF, UK
    Schizophr Bull 38:695-703. 2012
    ..there is currently insufficient evidence to fully understand the neurobiological substrate of auditory hallucinations (AH)...
  3. pmc Mobile Assessment and Treatment for Schizophrenia (MATS): a pilot trial of an interactive text-messaging intervention for medication adherence, socialization, and auditory hallucinations
    Eric Granholm
    Psychology Service, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Schizophr Bull 38:414-25. 2012
    ..Three MATS interventions were developed to target medication adherence, socialization, and auditory hallucinations. Participants received up to 840 text messages over a 12-week intervention period...
  4. ncbi The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years
    Mariese A Hely
    Department of Neurology, Westmead Hospital, Westmead, New South Wales, Australia
    Mov Disord 23:837-44. 2008
    ..postural hypotension in 48%, urinary incontinence in 71%, moderate dysarthria in 81%, choking in 48%, and hallucinations in 74%...
  5. pmc The characteristic features of auditory verbal hallucinations in clinical and nonclinical groups: state-of-the-art overview and future directions
    Frank Larøi
    Department of Psychology, FAPSE, University of Liege, 4000 Liege, Belgium
    Schizophr Bull 38:724-33. 2012
    Despite a growing interest in auditory verbal hallucinations (AVHs) in different clinical and nonclinical groups, the phenomenological characteristics of such experiences have not yet been reviewed and contrasted, limiting our ..
  6. ncbi Applying interpersonal theories to the understanding of and therapy for auditory hallucinations: a review of the literature and directions for further research
    Mark Hayward
    University of Sussex and Sussex Partnership NHS Foundation Trust, Nevill Avenue, Hove BN3 7HZ, UK
    Clin Psychol Rev 31:1313-23. 2011
    Cognitive models of auditory hallucinations are being elaborated in an attempt to more fully understand the variables that determine the distress often experienced by hearers...
  7. ncbi The role of social schema in the experience of auditory hallucinations: a systematic review and a proposal for the inclusion of social schema in a cognitive behavioural model of voice hearing
    Georgie Paulik
    School of Psychiatry, University of New South Wales, Australia
    Clin Psychol Psychother 19:459-72. 2012
    ..These clinical studies, as well as clinical implications drawn from the reviewed literature, will be discussed...
  8. ncbi Cortical activations during auditory verbal hallucinations in schizophrenia: a coordinate-based meta-analysis
    Renaud Jardri
    CNRS, University Lille North of France, France
    Am J Psychiatry 168:73-81. 2011
    Auditory verbal hallucinations (AVHs) constitute severe, incapacitating symptoms of schizophrenia...
  9. ncbi Structural correlates of auditory hallucinations in schizophrenia: a meta-analysis
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Schizophr Res 137:169-73. 2012
    Despite being one of the most common symptoms of schizophrenia, determining the neural correlates of auditory hallucinations still remains elusive with various studies providing inconsistent results.
  10. ncbi How can the brain's resting state activity generate hallucinations? A 'resting state hypothesis' of auditory verbal hallucinations
    Georg Northoff
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research IMHR, 1145 Carling Avenue, Ottawa, ON K1Z 7K4, Canada
    Schizophr Res 127:202-14. 2011
    While several hypotheses about the neural mechanisms underlying auditory verbal hallucinations (AVH) have been suggested, the exact role of the recently highlighted intrinsic resting state activity of the brain remains unclear...
  11. ncbi Evidence for sensory prediction deficits in schizophrenia
    Sukhwinder S Shergill
    Institute of Neurology, University College London
    Am J Psychiatry 162:2384-6. 2005
    Patients with schizophrenia experiencing delusions and hallucinations can misattribute their own actions to an external source...
  12. ncbi Avoiding false negatives: are some auditory hallucinations an evolved design flaw?
    Guy Dodgson
    Northumberland Tyne and Wear NHS Trust, UK
    Behav Cogn Psychother 37:325-34. 2009
    This paper draws on cognitive psychology research and clinical observation to propose a model for the formation of auditory hallucinations that are located externally, and experienced in noisy environments.
  13. ncbi Neuroanatomy of auditory verbal hallucinations in schizophrenia: a quantitative meta-analysis of voxel-based morphometry studies
    Gemma Modinos
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
    Cortex 49:1046-55. 2013
    ..for detecting associations between specific psychotic symptoms and brain structure, such as auditory verbal hallucinations (AVHs)...
  14. ncbi Deactivation of the parahippocampal gyrus preceding auditory hallucinations in schizophrenia
    Kelly M J Diederen
    Department of Psychiatry, Neuroscience Division, University Medical Center, Utrecht, The Netherlands
    Am J Psychiatry 167:427-35. 2010
    Activation in a network of language-related regions has been reported during auditory verbal hallucinations. It remains unclear, however, how this activation is triggered...
  15. ncbi Examining transcranial direct-current stimulation (tDCS) as a treatment for hallucinations in schizophrenia
    Jerome Brunelin
    University of Lyon, Lyon, France
    Am J Psychiatry 169:719-24. 2012
    Some 25%–30% of patients with schizophrenia have auditory verbal hallucinations that are refractory to antipsychotic drugs...
  16. ncbi Connecting neurosis and psychosis: the direct influence of emotion on delusions and hallucinations
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, University of London, Denmark Hill, London SE5 8AF, UK
    Behav Res Ther 41:923-47. 2003
    ..and experimental evidence concerning the influence of emotion on the content and form of delusions and hallucinations are therefore reviewed...
  17. pmc Self-recognition deficits in schizophrenia patients with auditory hallucinations: a meta-analysis of the literature
    Flavie Waters
    Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, Mail Bag No 1, Claremont, Perth, 6910, Australia
    Schizophr Bull 38:741-50. 2012
    Theories about auditory hallucinations in schizophrenia suggest that these experiences occur because patients fail to recognize thoughts and mental events as self-generated...
  18. pmc Auditory hallucinations elicit similar brain activation in psychotic and nonpsychotic individuals
    Kelly M J Diederen
    Department of Psychiatry, Neuroscience Division, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, The Netherlands
    Schizophr Bull 38:1074-82. 2012
    While auditory verbal hallucinations (AVH) are most characteristic for schizophrenia, they also occur in nonpsychotic individuals in the absence of a psychiatric or neurological disorder and in the absence of substance abuse...
  19. ncbi Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal area
    Ans Vercammen
    Department of Neuroscience, University Medical Center Groningen, BCN Neuroimaging Center, University of Groningen, The Netherlands
    Biol Psychiatry 67:912-8. 2010
    ..The current study aimed to investigate the relationship between auditory-verbal hallucinations (AVH), a particularly prevalent and clinically relevant symptom in schizophrenia, and functional connectivity ..
  20. ncbi The same or different? A phenomenological comparison of auditory verbal hallucinations in healthy and psychotic individuals
    Kirstin Daalman
    Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Clin Psychiatry 72:320-5. 2011
    Whereas auditory verbal hallucinations (AVHs) are most characteristic of schizophrenia, their presence has frequently been described in a continuum, ranging from severely psychotic patients to schizotypal personality disorder patients to ..
  21. ncbi Relationship of imprecise corollary discharge in schizophrenia to auditory hallucinations
    Theda H Heinks-Maldonado
    Department of Neuropsychology, Albert Ludwigs Universitat, Freiburg, Germany
    Arch Gen Psychiatry 64:286-96. 2007
    ..Imprecision of the corollary discharge in schizophrenia may contribute to the misperception of inner experiences and thoughts as "voices" or auditory hallucinations.
  22. ncbi The hallucinating brain: a review of structural and functional neuroimaging studies of hallucinations
    Paul Allen
    Kings College London, Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, London, UK
    Neurosci Biobehav Rev 32:175-91. 2008
    b>Hallucinations remains one of the most intriguing phenomena in psychopathology...
  23. ncbi Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations
    Stephen M Lawrie
    University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, UK
    Biol Psychiatry 51:1008-11. 2002
    ..We used functional magnetic resonance imaging (fMRI) to investigate the frontotemporal disconnection hypothesis of schizophrenia...
  24. ncbi Hallucinations in Parkinson's disease: prevalence, phenomenology and risk factors
    G Fenelon
    Department of Neurology, Hopital Tenon, Paris, France
    Brain 123:733-45. 2000
    b>Hallucinations, mainly of a visual nature, are considered to affect about one-quarter of patients with Parkinson's disease. They are commonly viewed as a side-effect of antiparkinsonian treatment, but other factors may be involved...
  25. ncbi Culture and the prevalence of hallucinations in schizophrenia
    Susanne M Bauer
    Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria
    Compr Psychiatry 52:319-25. 2011
    ..familial, and biographical factors, culture and ethnicity may plausibly influence the manifestation of hallucinations. The purpose of this study was to investigate the influence of culture on the frequency of different kinds of ..
  26. ncbi Contributions of emotional prosody comprehension deficits to the formation of auditory verbal hallucinations in schizophrenia
    Lucy Alba-Ferrara
    Roskamp Laboratory of Brain Development, Modulation and Repair Department of Psychiatry and Neurosciences, Morsani College of Medicine, University of South Florida, FL, USA
    Clin Psychol Rev 32:244-50. 2012
    ..This review focuses on the relation between emotional processing deficits and auditory verbal hallucinations (AVH)...
  27. ncbi Meta-analysis of repetitive transcranial magnetic stimulation in the treatment of auditory verbal hallucinations: update and effects after one month
    C W Slotema
    Parnassia Bavo Psychiatric Institute, Lijnbaan 4, 2512 VA The Hague, The Netherlands
    Schizophr Res 142:40-5. 2012
    Several meta-analyses considering repetitive transcranial magnetic stimulation (rTMS) for auditory verbal hallucinations (AVH) have been performed with moderate to high mean weighted effect sizes...
  28. ncbi Determinants of occurrence and recovery from hallucinations in daily life
    Philippe Delespaul
    Maastricht University, Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience, The Netherlands
    Soc Psychiatry Psychiatr Epidemiol 37:97-104. 2002
    ..Data related to the dynamics of hallucinatory experiences of patients suffering from schizophrenia are scarce. Detecting antecedent conditions and coping strategies may aid development of targeted psychological interventions...
  29. ncbi Reduced neuronal activity in language-related regions after transcranial magnetic stimulation therapy for auditory verbal hallucinations
    Jochen Kindler
    Department of Psychiatric Neurophysiology, University Hospital of Psychiatry, Bern, Switzerland
    Biol Psychiatry 73:518-24. 2013
    ..stimulation (TMS) is a novel therapeutic approach, used in patients with pharmacoresistant auditory verbal hallucinations (AVH)...
  30. ncbi Aberrations in the arcuate fasciculus are associated with auditory verbal hallucinations in psychotic and in non-psychotic individuals
    Antoin D de Weijer
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Hum Brain Mapp 34:626-34. 2013
    The pathophysiology of auditory verbal hallucinations (AVH) is still unclear. Cognitive as well as electrophysiological studies indicate that a defect in sensory feedback (corollary discharge) may contribute to the experience of AVH...
  31. ncbi Auditory verbal hallucinations and cognitive functioning in healthy individuals
    Kirstin Daalman
    Department of Psychiatry, Neuroscience Division, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Res 132:203-7. 2011
    Auditory verbal hallucinations (AVH) are a characteristic symptom in schizophrenia, and also occur in the general, non-clinical population...
  32. ncbi The neurodynamic organization of modality-dependent hallucinations
    Renaud Jardri
    Universite Lille Nord de France, F 59000 Lille, France
    Cereb Cortex 23:1108-17. 2013
    The pathophysiology of hallucinations remains mysterious. This research aims to specifically explore the interaction between hallucinations and spontaneous resting-state activity...
  33. pmc Dopaminergic function in the psychosis spectrum: an [18F]-DOPA imaging study in healthy individuals with auditory hallucinations
    Oliver D Howes
    Psychiatric Imaging Group, MRC Clinical Science Centre, Imperial College Hammersmith Campus, London, UK
    Schizophr Bull 39:807-14. 2013
    ..We investigated whether the dopaminergic dysfunction seen in psychotic disorders is also present in healthy, well-functioning people with hallucinations.
  34. pmc The cognitive neuropsychology of auditory hallucinations: a parallel auditory pathways framework
    Johanna C Badcock
    School of Psychiatry and Clinical Neurosciences, The University of Western Australia and Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, Australia, Mail Bag No 1, Claremont, Perth, 6910, Australia
    Schizophr Bull 36:576-84. 2010
    Auditory hallucinations are generally defined as false perceptions...
  35. pmc Subjective loudness and reality of auditory verbal hallucinations and activation of the inner speech processing network
    Ans Vercammen
    Department of Neuroscience, University Medical Center Groningen, Groningen, The Netherlands
    Schizophr Bull 37:1009-16. 2011
    One of the most influential cognitive models of auditory verbal hallucinations (AVH) suggests that a failure to adequately monitor the production of one's own inner speech leads to verbal thought being misidentified as an alien voice...
  36. ncbi Visual hallucinatory syndromes and the anatomy of the visual brain
    A M Santhouse
    Institute of Psychiatry, London, UK
    Brain 123:2055-64. 2000
    ..identify phenomenological correlates of cerebral functional architecture within Charles Bonnet syndrome (CBS) hallucinations by looking for associations between specific hallucination categories...
  37. ncbi Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia
    Shitij Kapur
    Clarke Division of the Centre for Addiction and Mental Health, 250 College St, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 160:13-23. 2003
    ..The objective of this overview is to link the neurobiology (brain), the phenomenological experience (mind), and pharmacological aspects of psychosis-in-schizophrenia into a unitary framework...
  38. ncbi Impaired visual processing preceding image recognition in Parkinson's disease patients with visual hallucinations
    Anne Marthe Meppelink
    Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Brain 132:2980-93. 2009
    Impaired visual processing may play a role in the pathophysiology of visual hallucinations in Parkinson's disease...
  39. ncbi Auditory verbal hallucinations predominantly activate the right inferior frontal area
    Iris E C Sommer
    Neuroscience Division, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Heidelberglaan, Netherlands
    Brain 131:3169-77. 2008
    The pathophysiology of auditory verbal hallucinations (AVH) is largely unknown...
  40. ncbi Hallucinations, REM sleep, and Parkinson's disease: a medical hypothesis
    I Arnulf
    centre d investigation clinique, Fédération de Neurologie and INSERM U 289
    Neurology 55:281-8. 2000
    Patients with PD can have disabling visual hallucinations associated with dopaminergic therapy. Sleep disorders, including vivid dreams and REM sleep with motor behaviors (RBD), are frequent in these patients.
  41. ncbi Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe
    A J Harding
    Prince of Wales Medical Research Institute and University of New South Wales, Barker Street, Sydney, NSW 2031, Australia
    Brain 125:391-403. 2002
    ..with Lewy bodies (DLB) as a progressive dementing illness, with significant fluctuations in cognition, visual hallucinations and/or parkinsonism...
  42. ncbi Interpersonal and role-related schema influence the relationship with the dominant 'voice' in schizophrenia: a comparison of three models
    Max Birchwood
    Birmingham and Solihull Mental Health Trust
    Psychol Med 34:1571-80. 2004
    Auditory hallucinations in psychosis often contain critical evaluations of the voice-hearer (for example, attacks on self-worth)...
  43. ncbi Thought as action: inner speech, self-monitoring, and auditory verbal hallucinations
    Simon R Jones
    Department of Psychology, University of Durham, Durham, UK
    Conscious Cogn 16:391-9. 2007
    ..Drawing on the assumption that inner speech is a form of action, a recent model of auditory verbal hallucinations (AVHs) has proposed that AVHs can be explained by a failure in the NASS...
  44. ncbi Cognitive mechanisms of auditory verbal hallucinations in psychotic and non-psychotic groups
    Johanna C Badcock
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Neurosci Biobehav Rev 36:431-8. 2012
    ..It assumes that psychotic symptoms, such as auditory verbal hallucinations (AVH), are not limited to patients with psychosis but also occur in healthy, non-clinical individuals - ..
  45. pmc Healthy individuals with auditory verbal hallucinations; who are they? Psychiatric assessments of a selected sample of 103 subjects
    Iris E C Sommer
    Neuroscience Division University Medical Center Utrecht, B01 206, Rudolf Magnus School for Neuroscience, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Bull 36:633-41. 2010
    Epidemiological studies suggest that auditory verbal hallucinations (AVH) occur in approximately 10%-15% of the general population, of whom only a small proportion has a clinically relevant psychotic disorder...
  46. ncbi Reviewing evidence for the cognitive model of auditory hallucinations: The relationship between cognitive voice appraisals and distress during psychosis
    Amy Mawson
    Division of Health Research, Lancaster University, Bailrigg, Lancaster LA1 4YT, UK
    Clin Psychol Rev 30:248-58. 2010
    ....
  47. ncbi Trauma and hallucinatory experience in psychosis
    Amy Hardy
    Institute of Psychiatry, Kings College London, London, United Kingdom
    J Nerv Ment Dis 193:501-7. 2005
    ..research indicates that there may be phenomenological, symptom, and diagnostic associations between trauma and hallucinations. However, the nature of the relationship is poorly understood from a psychological perspective...
  48. pmc Quantitative meta-analysis on state and trait aspects of auditory verbal hallucinations in schizophrenia
    Simone Kühn
    Department of Experimental Psychology and Ghent Institute for Functional and Metabolic Imaging, Faculty of Psychology and Educational Sciences, Ghent University, Henri Dunantlaan 2, 9000 Gent, Belgium
    Schizophr Bull 38:779-86. 2012
    Auditory verbal hallucinations (AVHs) have a high prevalence in schizophrenic patients...
  49. ncbi Change in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Psychiatry Res 139:79-88. 2005
    Fluctuations in consciousness and visual hallucinations are common neuropsychiatric features of dementia with Lewy bodies and Parkinson's disease dementia...
  50. ncbi The brain's voices: comparing nonclinical auditory hallucinations and imagery
    David E J Linden
    Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, UK
    Cereb Cortex 21:330-7. 2011
    Although auditory verbal hallucinations are often thought to denote mental illness, the majority of voice hearers do not satisfy the criteria for a psychiatric disorder...
  51. ncbi Decreased language lateralization is characteristic of psychosis, not auditory hallucinations
    Kelly M J Diederen
    Neuroscience Division, Department of Psychiatry, University Medical Centre Utrecht and Rudolf Magnus Institute for Neuroscience, Heidelberglaan, The Netherlands
    Brain 133:3734-44. 2010
    ..It has been argued that decreased language lateralization may be related to auditory verbal hallucinations. To elucidate this, these hallucinations should be studied in isolation...
  52. ncbi Emotion and psychosis: links between depression, self-esteem, negative schematic beliefs and delusions and hallucinations
    Ben Smith
    UCL, Department of Mental Health Sciences, Archway Campus, Holborn Union Building, Highgate Hill, London, UK
    Schizophr Res 86:181-8. 2006
    ..A., Kuipers, E.K., Fowler, D., Freeman, D., Bebbington, P.E., 2001. A cognitive model of the positive symptoms of psychosis. Psychological Medicine, 31, 189-195] about the role of emotion and negative evaluative beliefs in psychosis...
  53. ncbi Visual misperceptions and hallucinations in Parkinson's disease: dysfunction of attentional control networks?
    James M Shine
    Ageing Brain Centre, Brain and Mind Research Institute, The University of Sydney, Sydney, NSW, Australia
    Mov Disord 26:2154-9. 2011
    Visual misperceptions and hallucinations are a major cause of distress in patients with Parkinson's disease (PD), particularly in the advanced stages of the condition...
  54. ncbi Auditory hallucinations and reduced language lateralization in schizophrenia: a meta-analysis of dichotic listening studies
    Sebastian Ocklenburg
    Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway
    J Int Neuropsychol Soc 19:410-8. 2013
    ..Recent studies suggest that auditory hallucinations are critical for whether a patient shows reduced language lateralization...
  55. ncbi Possible dysregulation of cortical plasticity in auditory verbal hallucinations-A cortical thickness study in schizophrenia
    Claudia van Swam
    Dept of Psychiatric Neurophysiology, University Hospital of Psychiatry Bern, Bolligenstrasse 111, Bern, Switzerland
    J Psychiatr Res 46:1015-23. 2012
    Investigations of gray matter changes in relation with auditory verbal hallucinations (AVH) have reported conflicting results...
  56. ncbi The "paradoxical" engagement of the primary auditory cortex in patients with auditory verbal hallucinations: a meta-analysis of functional neuroimaging studies
    Kristiina Kompus
    Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway
    Neuropsychologia 49:3361-9. 2011
    The existing literature on neuroimaging studies of auditory verbal hallucinations (AVHs) in patients with schizophrenia contains an apparent "paradox" in that the same areas in the auditory cortex seem to be both activated and deactivated ..
  57. ncbi The internal structure of the phenomenology of auditory verbal hallucinations
    Massoud Stephane
    Department of Psychiatry, VA Medical Center University of Minnesota, One Veterans Drive, 55417, Minneapolis, MN, USA
    Schizophr Res 61:185-93. 2003
    Auditory verbal hallucinations (AVH) do not have uniform pathological significance. They affect patients with different brain disorders, and vary along multiple phenomenological dimensions...
  58. ncbi Auditory verbal hallucinations in patients with borderline personality disorder are similar to those in schizophrenia
    C W Slotema
    Parnassia Bavo Psychiatric Institute, The Hague, The Netherlands
    Psychol Med 42:1873-8. 2012
    Auditory verbal hallucinations (AVH) in patients with borderline personality disorder (BPD) are frequently claimed to be brief, less severe and qualitatively different from those in schizophrenia, hence the term 'pseudohallucinations'...
  59. pmc Resting state functional connectivity in patients with chronic hallucinations
    Iris E Sommer
    Psychiatry Department, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
    PLoS ONE 7:e43516. 2012
    Auditory verbal hallucinations (AVH) are not only among the most common but also one of the most distressing symptoms of schizophrenia. Despite elaborate research, the underlying brain mechanisms are as yet elusive...
  60. pmc Cerebral blood flow identifies responders to transcranial magnetic stimulation in auditory verbal hallucinations
    P Homan
    Department of Psychiatric Neurophysiology, University Hospital of Psychiatry, University of Bern, Bern, Switzerland
    Transl Psychiatry 2:e189. 2012
    Auditory hallucinations comprise a critical domain of psychopathology in schizophrenia. Repetitive transcranial magnetic stimulation (TMS) has shown promise as an intervention with both positive and negative reports...
  61. ncbi Left superior temporal gyrus activation during sentence perception negatively correlates with auditory hallucination severity in schizophrenia patients
    Marion Plaze
    Inserm U 797, CEA INSERM Research Unit Neuroimaging and Psychiatry, Atomic Energy Commission CEA Hospital Department Frédéric Joliot, IFR49, Paris Sud 11 and Paris 5 Universities 4 place Gl Leclerc 91401, Orsay, France
    Schizophr Res 87:109-15. 2006
    ..cortex, which supports linguistic functions, has consistently been reported to activate during auditory-verbal hallucinations in schizophrenia patients...
  62. ncbi Prevalence of hallucinations and their pathological associations in the general population
    M M Ohayon
    Sleep Disorders Center, Stanford University, School of Medicine, 401Quarry Road, Suite 3301, Stanford CA 94305, USA
    Psychiatry Res 97:153-64. 2000
    b>Hallucinations are perceptual phenomena involved in many fields of pathology. Although clinically widely explored, studies in the general population of these phenomena are scant...
  63. ncbi Dichotic listening in schizophrenic patients: effects of previous vs. ongoing auditory hallucinations
    Else Marie Løberg
    Department of Biological and Medical Psychology, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Psychiatry Res 128:167-74. 2004
    Auditory hallucinations (AH) in schizophrenia have been found to be related to both functional and structural brain abnormalities of left temporal lobe language areas...
  64. ncbi Auditory hallucinations in childhood: associations with adversity and delusional ideation
    A A Bartels-Velthuis
    University Medical Center Groningen, University Center for Psychiatry, University of Groningen, Groningen, The Netherlands
    Psychol Med 42:583-93. 2012
    Previous work suggests that exposure to childhood adversity is associated with the combination of delusions and hallucinations. In the present study, associations between (severity of) auditory vocal hallucinations (AVH) and (i) social ..
  65. ncbi Cognitive biases and auditory verbal hallucinations in healthy and clinical individuals
    K Daalman
    Department of Psychiatry, Neuroscience Division, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
    Psychol Med 43:2339-47. 2013
    Several cognitive biases are related to psychotic symptoms, including auditory verbal hallucinations (AVH). It remains unclear whether these biases differ in voice-hearers with and without a 'need-for-care'.
  66. pmc 17q24.2 microdeletions: a new syndromal entity with intellectual disability, truncal obesity, mood swings and hallucinations
    Sarah Vergult
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Eur J Hum Genet 20:534-9. 2012
    ..b>Hallucinations and mood swings were also noted in two patients...
  67. ncbi Confusion between silent and overt reading in schizophrenia
    N Franck
    Institut des Sciences Cognitives, CNRS UPR 9075, Bron, France
    Schizophr Res 41:357-64. 2000
    ..Our data favour the hypothesis that the inability to correctly discriminate between inner and overt speech may play a role in the onset of schizophrenic hallucinations.
  68. ncbi On the non-significance of internal versus external auditory hallucinations
    David Copolov
    Mental Health Research Institute, Victoria
    Schizophr Res 69:1-6. 2004
    Traditionally, auditory hallucinations (AHs) heard outside the head have been regarded as more pathological than those heard inside, partly on the basis that internal AHs are conceptually closer to normal thinking than external AHs...
  69. ncbi Emotional prosodic processing in auditory hallucinations
    T L Shea
    Centre for Neuroscience, University of Melbourne, Parkville VIC 3052, Australia
    Schizophr Res 90:214-20. 2007
    ..has proposed that prosodic deficits may contribute to the misattribution that appears to occur in auditory hallucinations in psychosis...
  70. ncbi White matter abnormalities associated with auditory hallucinations in schizophrenia: a combined study of voxel-based analyses of diffusion tensor imaging and structural magnetic resonance imaging
    Jeong Ho Seok
    Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Severance Mental Health Hospital, 696 6 Tanbul dong Gwangju, Gyeonggi, 464 100 South Korea
    Psychiatry Res 156:93-104. 2007
    ..The aim of this study was to elucidate a WM basis of auditory hallucinations in schizophrenia through the simultaneous investigation of WM tract integrity and WM density...
  71. pmc Hallucinations, sensory neuropathy, and peripheral visual deficits in a young woman infected with Bartonella koehlerae
    Edward B Breitschwerdt
    North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Clin Microbiol 49:3415-7. 2011
    ..muscle spasms, interphalangeal joint stiffness, decreased peripheral vision, diminished tactile sensation, and hallucinations was persistently Bartonella koehlerae seroreactive and bacteremic. Following antibiotic treatment, B...
  72. pmc Where the imaginal appears real: a positron emission tomography study of auditory hallucinations
    H Szechtman
    Department of Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Proc Natl Acad Sci U S A 95:1956-60. 1998
    ..world, we used positron emission tomography to identify neural sites activated by both real hearing and hallucinations but not by imaginal hearing...
  73. ncbi Repetitive transcranial magnetic stimulation in schizophrenic patients reporting auditory hallucinations
    Giorgio Chibbaro
    Department of Psychiatric Sciences, University of Catania, Italy
    Neurosci Lett 383:54-7. 2005
    Auditory hallucinations are experienced by 60-80% of person with schizophrenia and can often cause significant distress behavioural dyscontrol...
  74. ncbi Effects of the traditional Chinese herbal medicine Yi-Gan San for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in patients with dementia with Lewy bodies
    Koh Iwasaki
    J Clin Psychiatry 66:1612-3. 2005
  75. ncbi The anatomy of conscious vision: an fMRI study of visual hallucinations
    D H Ffytche
    Institute of Psychiatry, London, UK
    Nat Neurosci 1:738-42. 1998
    ..We found that hallucinations of color, faces, textures and objects correlate with cerebral activity in ventral extrastriate visual cortex, ..
  76. ncbi Serotonin 2A receptors and visual hallucinations in Parkinson disease
    Benedicte Ballanger
    Vivian M Rakoff PET Centre, Toronto Western Hospital, Toronto, Ontario, Canada
    Arch Neurol 67:416-21. 2010
    Complex visual hallucinations (VHs) occur in several pathologic conditions; however, the neural mechanisms underlying these symptoms remain unclear...
  77. ncbi Metabolic alterations in patients with Parkinson disease and visual hallucinations
    Henning Boecker
    Department of Nuclear Medicine, Technische Universitat Munchen, Munchen, Germany
    Arch Neurol 64:984-8. 2007
    Visual hallucinations (VHs) occur frequently in advanced stages of Parkinson disease (PD). Which brain regions are affected in PD with VH is not well understood.
  78. ncbi Hallucinations and other psychotic symptoms associated with the use of attention-deficit/hyperactivity disorder drugs in children
    Andrew D Mosholder
    Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993 0002, USA
    Pediatrics 123:611-6. 2009
    ....
  79. ncbi Brain response to complex visual stimuli in Parkinson's patients with hallucinations: a functional magnetic resonance imaging study
    Blanca Ramirez-Ruiz
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    Mov Disord 23:2335-43. 2008
    Visual hallucinations (VH) in Parkinson's disease (PD) have been associated with gray matter reductions in visual associative areas and with abnormal patterns of brain activation in posterior and frontal regions...
  80. ncbi Visual hallucination in Parkinson's disease with FDG PET
    Atsuko Nagano-Saito
    Department of Brain Science and Molecular Imaging, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Japan
    Mov Disord 19:801-6. 2004
    To determine the characteristics of cerebral glucose metabolism in Parkinson's disease patients with visual hallucinations, group comparison studies using [18F]fluorodeoxyglucose positron emission tomography were performed...
  81. ncbi Circadian rest-activity rhythm is altered in Parkinson's disease patients with hallucinations
    Daisy L Whitehead
    King s College London, Institute of Psychiatry, MRC Centre for Neurodegeneration, London, United Kingdom
    Mov Disord 23:1137-45. 2008
    ..This study compared rest-activity rhythms in healthy older adults and PD patients with and without hallucinations. Twenty-nine older adults and 50 PD patients (27 with hallucinations, 23 without) were assessed using wrist-..
  82. ncbi Cognitive therapy for command hallucinations: randomised controlled trial
    Peter Trower
    School of Psychology, University of Birmingham and Birmingham and Solihull Mental HealthTrust, UK
    Br J Psychiatry 184:312-20. 2004
    Command hallucinations are a distressing and high-risk group of symptoms that have long been recognised but little understood, with few effective treatments...
  83. ncbi Synch before you speak: auditory hallucinations in schizophrenia
    Judith M Ford
    Psychiatry Service, Veterans Affairs Connecticut Health Care System, USA
    Am J Psychiatry 164:458-66. 2007
    ..in this mechanism may be characteristic of schizophrenia and related to positive symptoms, such as auditory hallucinations. If so, schizophrenia patients should have reduced neural synchrony preceding movements, especially patients ..
  84. pmc Time course of regional brain activation associated with onset of auditory/verbal hallucinations
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Br J Psychiatry 193:424-5. 2008
    The time course of brain activation prior to onset of auditory/verbal hallucinations was characterised using functional magnetic resonance imaging in six dextral patients with schizophrenia...
  85. ncbi Misattribution of speech and impaired connectivity in patients with auditory verbal hallucinations
    Andrea Mechelli
    Division of Psychological Medicine, Section of Neuroimaging, King s College London, London, SE5 8AF, United Kingdom
    Hum Brain Mapp 28:1213-22. 2007
    Several studies report that patients with schizophrenia who experience auditory verbal hallucinations (AVH) tend to misidentify their own speech as that of somebody else...
  86. ncbi Cerebral atrophy in Parkinson's disease patients with visual hallucinations
    B Ramirez-Ruiz
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    Eur J Neurol 14:750-6. 2007
    Although visual hallucinations (VH) are relatively frequent in Parkinson's disease (PD) patients, their neural substrates are only known from neuropathological and functional magnetic resonance studies...
  87. ncbi "Hearing voices": auditory hallucinations as failure of top-down control of bottom-up perceptual processes
    Kenneth Hugdahl
    Department of Biological and Medical Psychology, University of Bergen, Norway
    Scand J Psychol 50:553-60. 2009
    ..A view on auditory hallucinations and "hearing voices" is presented that regards such phenomena as perceptual processes, originating from speech ..
  88. ncbi Visual hallucinations in the diagnosis of idiopathic Parkinson's disease: a retrospective autopsy study
    David R Williams
    Queen Square Brain Bank for Neurological Disorders and Institute of Neurology, University College London, London, UK
    Lancet Neurol 4:605-10. 2005
    For many years, visual hallucinations (VH) in idiopathic Parkinson's disease (PD) were thought to be a complication of antiparkinsonian treatment...
  89. ncbi Risk factors for somnolence, edema, and hallucinations in early Parkinson disease
    Kevin M Biglan
    University of Rochester, Department of Neurology, Rochester, NY 14620, USA
    Neurology 69:187-95. 2007
    ..A secondary finding of the trial was a higher than anticipated development or worsening of somnolence and edema and development of hallucinations.
  90. ncbi The dreamy state: hallucinations of autobiographic memory evoked by temporal lobe stimulations and seizures
    Jean Pierre Vignal
    Service de Neurologie, Hopital Central, CHU de Nancy, France
    Brain 130:88-99. 2007
    ..Taylor J, editor. London: Hodder and Stoughton; 1931). A total of 15 sensations of déjà vécu, 35 visual hallucinations consisting of the image of a scene and 5 'feelings of strangeness' occurred...
  91. ncbi Verbal self-monitoring and auditory verbal hallucinations in patients with schizophrenia
    L C Johns
    Department of Psychology, Institute of Psychiatry, London
    Psychol Med 31:705-15. 2001
    BACKGROUND: Contemporary cognitive models of auditory verbal hallucinations propose that they arise through defective self-monitoring...
  92. ncbi Neuropsychiatric symptoms of patients with progressive supranuclear palsy and Parkinson's disease
    D Aarsland
    Geriatric Psychiatry, Rogaland Psychiatric Hospital, Norway
    J Neuropsychiatry Clin Neurosci 13:42-9. 2001
    ..PSP patients showed significantly more apathy and disinhibition. Patients with PD had higher frequency of hallucinations, delusions, and depression...
  93. ncbi Why people see things that are not there: a novel Perception and Attention Deficit model for recurrent complex visual hallucinations
    Daniel Collerton
    South of Tyne and Wearside Mental Health NHS Trust, Bensham Hospital, Gateshead NE8 4YL, United Kingdom
    Behav Brain Sci 28:737-57; discussion 757-94. 2005
    ..b>Hallucinations on the border of sleep, dementing illnesses, delirium, eye disease, and schizophrenia account for 90% of these...
  94. ncbi Repeated visual hallucinations in Parkinson's disease as disturbed external/internal perceptions: focused review and a new integrative model
    Nico J Diederich
    Department of Neuroscience, Centre Hospitalier de Luxembourg, Luxembourg
    Mov Disord 20:130-40. 2005
    Visual hallucinations (VH) in Parkinson's disease (PD) are a chronic complication in 30 to 60% of treated patients and have a multifaceted phenomenology...
  95. ncbi Misattribution of external speech in patients with hallucinations and delusions
    Paul P Allen
    Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, P O BOX 67, Denmark Hill, London SE5 8AF, UK
    Schizophr Res 69:277-87. 2004
    ..We examined whether patients with hallucinations and delusions would demonstrate an externalising bias on a task that did not involve cognitive self-monitoring.
  96. ncbi Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease
    Masaaki Hirayama
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Parkinsonism Relat Disord 17:46-9. 2011
    ..ROS including hydroxyl radicals and H(2)O(2) react with guanine residues in DNA and produce 8-hydroxydeoxyguanosine (8-OHdG). 8-OHdG serves as a biomarker for oxidative stress in various diseases...
  97. ncbi Complex visual hallucinations in the visually impaired: a structured history-taking approach
    G Jayakrishna Menon
    Royal Eye Infirmary, Plymouth, England
    Arch Ophthalmol 123:349-55. 2005
    To study complex visual hallucinations in visually impaired individuals.
  98. ncbi Auditory verbal hallucinations and dysfunction of the neural substrates of speech
    M Stephane
    Department of Psychiatry, Johns Hopkins Medical Institutions, JHOC Research Room # 3245, 601 North Caroline Street, Baltimore, MD 21287, USA
    Schizophr Res 50:61-78. 2001
    OBJECTIVE: to evaluate the neural substrate of auditory verbal hallucinations (AVH), the correlation between AVH and subvocal speech (hereafter SVS), and the relationship between speech and AVH...
  99. ncbi Cognitive and emotional predictors of predisposition to hallucinations in non-patients
    Anthony P Morrison
    Psychology Services, Mental Health Services of Salford, UK
    Br J Clin Psychol 41:259-70. 2002
    ..Inventory: IVI) and a revision of the Launay-Slade Hallucination Scale (RHS) to measure predisposition to hallucinations in non-patients...
  100. ncbi Auditory verbal hallucinations in schizophrenia as aberrant lateralized speech perception: evidence from dichotic listening
    Kenneth Hugdahl
    Department of Biological and Medical Psychology, University of Bergen, Norway
    Schizophr Res 140:59-64. 2012
    We report evidence that auditory verbal hallucinations (AVH) in schizophrenia patients are perceptual distortions lateralized to the left hemisphere...
  101. ncbi Can low-frequency repetitive transcranial magnetic stimulation really relieve medication-resistant auditory verbal hallucinations? Negative results from a large randomized controlled trial
    Christina W Slotema
    Parnassia Bavo Psychiatric Institute, Lijnbaan 4, The Hague, The Netherlands
    Biol Psychiatry 69:450-6. 2011
    ..stimulation (rTMS) directed at the left temporoparietal area (TP) for the treatment of auditory verbal hallucinations (AVH), but findings on efficacy are inconsistent...

Research Grants63

  1. PARTIAL DOPAMINEAGONIST TREATMENT OF SCHIZOPHRENIA
    Carol Tamminga; Fiscal Year: 2002
    ..in each of these three aims will be evaluated in the three primary symptom cluster of schizophrenia: 1) hallucinations/delusions; 2) disorganization, and 3) negative symptoms, and on cognitive function...
  2. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..Current treatment, while generally effective for reducing positive psychotic symptoms(delusions, hallucinations, thought disorder) frequently leads to a number of untoward side-effects...
  3. Glucocerebrosidase mutations in a mouse synucleinopathy model
    Robert L Nussbaum; Fiscal Year: 2011
    ..clinically similar to AD but characteristically shows a higher frequency of psychosis with auditory and visual hallucinations and is often accompanied by the symptoms and signs of Parkinsonism...
  4. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2012
    ..AD, many patients exhibit a range of non-cognitive symptoms that include depression, aggression, delusions and hallucinations. Whilst the neuropathological changes associated with AD have been well characterized in post-mortem brain ..
  5. Mechanisms of Alcohol Withdrawal
    Dwayne W Godwin; Fiscal Year: 2012
    ..the clinical symptoms of alcohol withdrawal can range from mild to gross tremors, hyperactivity, confusion, hallucinations, sleep disruption and seizures...
  6. The Functional Significance of Conformational States in Glutamatergic Signaling
    CATHERINE LOURDES SALUSSOLIA; Fiscal Year: 2013
    ..g. drowsiness, hallucinations, and coma)...
  7. Chemistry and Biology of 5-HT2C Receptor Ligands for Drug Abuse
    ALAN PAUL KOZIKOWSKI; Fiscal Year: 2010
    ..For example, valvular heart disease is associated with activation of the 5-HT2B subtype and hallucinations are caused by activation of the 5-HT2AR...
  8. Serotonergic modulation of claustro-cortical circuits
    Jay A Gingrich; Fiscal Year: 2013
    ..The impairment in these brain functions offers possible insight into the symptoms of disorganization, hallucinations, delusions, lack of relatedness, involution, distractedness, and cognitive decline that characterize these ..
  9. Structural and Functional Alterations of Interneurons in Models of Schizophrenia
    Istvan Mody; Fiscal Year: 2012
    ..monoaminergic treatments for schizophrenia are most effective in treating positive symptoms, comprising hallucinations and/or delusions...
  10. In vitro tools for preclinical analysis of cognitive therapies for schizophrenia
    KRISTEN RICHARDSON; Fiscal Year: 2012
    ..Symptoms of schizophrenia are classified into three categories: positive (delusions and hallucinations), negative (flattened affect, social isolation) and cognitive (impaired attention, executive function, working ..
  11. Mechanism-based, pro-cognitive therapies for schizophrenia
    DAVID JULIAN GERBER; Fiscal Year: 2010
    ..Symptoms of schizophrenia can be grouped into three categories: positive symptoms, including hallucinations and delusions;negative symptoms, such as social isolation and flattened affect;and cognitive symptoms, which ..
  12. Influence of Psychosis on Brain-Behavior Endophenotypes for Bipolar Disorder
    David C Glahn; Fiscal Year: 2012
    ..neurocognitive and neuroimaging endophenotypes for the disorder must account for the potential impact of hallucinations and delusions on these markers...
  13. First-Episode Psychosis and Pre-Onset Cannabis Use
    Michael T Compton; Fiscal Year: 2012
    ..e., hallucinations and delusions), and the nature of negative, cognitive, neurological, and positive symptoms of schizophrenia...
  14. GABAergic and Reelin Deficits in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2013
    ..e., apathy, poor or nonexistent social functioning) and positive (presence of hallucinations, delusions) symptoms, and a lifetime prevalence of 1%...
  15. Plasticity-Based Adaptive Cognitive Remediation for Schizophrenia
    HENRY WILTSHIRE MAHNCKE; Fiscal Year: 2010
    ..time that these challenges in functional abilities were caused by the overt symptoms of schizophrenia, like hallucinations and delusions;however research has now shown that these challenges are largely a result of problems with ..
  16. In vivo methods for preclinical analysis of cognitive therapies for schizophrenia
    JONATHAN MAX LEVENSON; Fiscal Year: 2010
    ..Symptoms of schizophrenia can be grouped into three categories: positive symptoms, such as hallucinations;negative symptoms, such as social isolation and inappropriate emotional response;and cognitive symptoms...
  17. Effects of Parkinson's Disease on Perception, Cognition, and Gait
    Alice Cronin-Golomb; Fiscal Year: 2013
    ..and visuospatial impairments to daily function, including gait, motoric freezing, subjective quality of life, hallucinations, mood and other patient-centered features of PD...
  18. Towards understanding cellular mechanisms of positive symptoms of schizophrenia
    Stanislav S Zakharenko; Fiscal Year: 2013
    ..1% of the world's population and is characterized by a constellation of symptoms that include hallucinations and delusions (positive symptoms), antisocial behavior and blunted emotions (negative symptoms), deficits in ..
  19. Clinical and Neuropsychological Investigations in Batten Disease
    Jonathan W Mink; Fiscal Year: 2010
    ..In some individuals, aggressive behavior, anxiety, hallucinations, obsessions, or personality changes are prominent...
  20. Engrafting human neurons into animal models to study schizophrenia
    Krishnan Padmanabhan; Fiscal Year: 2013
    ..schizophrenia is a debilitating psychiatric disorder characterized by an array of symptoms including hallucinations, delusions, difficulty expressing emotions, and deficits in attention and memory...
  21. Amygdalar modulation of processing in auditory cortex
    DIANA COOMES PETERSON; Fiscal Year: 2012
    ..Abnormal processing in the amygdala has been linked to numerous psychiatric disorders that include auditory hallucinations (e.g., schizophrenia, bipolar disorder)...
  22. Microstructural Characterization of White Matter in Schizophrenia
    Mariana Lazar; Fiscal Year: 2010
    Schizophrenia is a chronic, severe, and disabling disorder that is characterized by hallucinations, delusions, and motor deficits...
  23. Using fMRI to Measure Negative Symptoms in Schizophrenia
    EDWARD E contact SMITH; Fiscal Year: 2010
    ..a devastating psychiatric disorder, is chiefly characterized by positive symptoms, such as delusions and hallucinations, and negative symptoms, such as anhedonia (lack of pleasure), avolition (lack of willed-action), and a ..
  24. Multimodal Imaging of Neuropsychiatric Disorders (MIND): Mechanisms &
    Vince D Calhoun; Fiscal Year: 2013
    ..Project 4 will focus on auditory hallucinations using MEG and fMRI...
  25. Schizophrenia Pharmacogenetics: cognition and symptom response to antipsychotics
    Jeffrey R Bishop; Fiscal Year: 2013
    ..Psychotic symptoms like hallucinations and delusions that occur with this disease often respond well to antipsychotic agents like risperidone...
  26. Identifying the clinicopathologic basis of dementia-related psychosis
    Katherine P Rankin; Fiscal Year: 2013
    ..the clinical phenomenology, neuroanatomy, and neuropathology underlying different types of delusions and hallucinations in three diseases of aging: Alzheimer's disease (AD), behavioral variant frontotemporal dementia (bvFTD) ..
  27. Pilot Trial of Bupropion versus Placebo for Methamphetamine Abuse in Adolescents
    KEITH GREGORY HEINZERLING; Fiscal Year: 2010
    ..public health problem that is associated with psychological distress, depressive symptoms, auditory hallucinations, suicidal ideation, and high rates of violent behavior and HIV-related sexual risk behaviors...
  28. Control of Attention by Working Memory
    Steven J Luck; Fiscal Year: 2013
    ..Although hallucinations and delusions are the most salient symptoms of this disease, schizophrenia also involves pervasive cognitive ..
  29. Optimization of Novel NR2C and NR2D subunit-selective NMDA receptor potentiators
    KAMALESH RUPPA; Fiscal Year: 2013
    ..2005). Current therapies to treat this disorder have been effective in ameliorating positive symptoms (hallucinations, delusions, irrational fear), but are less effective in controlling negative symptoms (social withdrawal, ..
  30. Dextras1, Brain Iron Homeostasis and Mental Health
    Sangwon F Kim; Fiscal Year: 2010
    Schizophrenia is commonly recognized by its psychotic symptoms such as delusions and hallucinations, which often leads to social and functional impairment...
  31. Novel serotonergic, pro-cognitive antipsychotic therapies
    Silvana Leit; Fiscal Year: 2012
    ..The symptoms of schizophrenia can be grouped into three major categories: positive (e.g. hallucinations and delusions), negative (e.g. social isolation and inappropriate emotional response), and cognitive symptoms...
  32. Prediction of Psychosis in Alzheimer Disease
    Robert A Sweet; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer Disease (AD+Psychosis, AD+P), affecting ~ 40% to 60% of individuals with AD...
  33. Using the EMR to identify and screen patients at risk for delirium
    Michelle Weckmann; Fiscal Year: 2013
    ..may be confused;in addition, delirium is commonly associated with rapid, intense mood changes, agitation, and hallucinations. Delirium is upsetting to the patient and everyone involved in his\her care...
  34. Evaluation of Mouse Hallucinations by fMRI
    Paul H Patterson; Fiscal Year: 2012
    ..and sensory-motor gating, it is said to be impossible to evaluate the positive symptoms of schizophrenia, hallucinations and delusions. Thus, this disorder is often considered to be "uniquely human"...
  35. Corollary Discharge Dysfunction in Schizophrenia: ERPs and EEG
    Judith M Ford; Fiscal Year: 2012
    ..It may also contribute to symptoms such as hallucinations, delusions, and even the desire to engage with people and in activities...
  36. Antipsychotic Effects on Top Down Control of Sensory Processing in Schizophrenia
    Sarah Keedy; Fiscal Year: 2013
    ..deficits in schizophrenia, much less is known about the pathophysiology leading to positive symptoms such as hallucinations. These abnormal sensory experiences often dominate the acute psychotic state...
  37. Glucocerebrosidase mutations in a mouse synucleinopathy model
    Robert L Nussbaum; Fiscal Year: 2010
    ..clinically similar to AD but characteristically shows a higher frequency of psychosis with auditory and visual hallucinations and is often accompanied by the symptoms and signs of Parkinsonism...
  38. Real time fMRI feedback and auditory processing in schizophrenia
    Margaret A Niznikiewicz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Auditory verbal hallucinations (AH) have long been a hallmark of schizophrenia (SZ) symptomatology and one of its major diagnostic features (Andreasen and Flaum, 1991;DSM-IV)...
  39. Clinical and Computational Studies of Dopamine Function in Schizophrenia
    James M Gold; Fiscal Year: 2013
    ..with cognitive deficits and negative symptoms than it is with the positive symptoms of the illness including hallucinations and delusions...
  40. Prefrontal anatomic pathways in executive control
    Helen Barbas; Fiscal Year: 2013
    ..cingulate and temporal auditory cortices are affected in schizophrenia, consistent with the auditory nature of hallucinations, distractibility and debilitating deficits in cognition...
  41. Neural connectivity and dysconnectivity in schizophrenia: EEG and fMRI studies
    Judith M Ford; Fiscal Year: 2013
    ..brain, including difficulties switching out of idle and into gear when tasks demand it and auditory verbal hallucinations. Using resting state activity as our conceptual starting point, we propose to use EEG+fMRI data to study (1) ..
  42. Quantitative Behavioral and Imaging Phenotypes of Amotivation in Schizophrenia
    Daniel H Wolf; Fiscal Year: 2013
    ..Unlike positive symptoms (hallucinations, delusions) which are generally responsive to antipsychotic medications, negative symptoms including ..
  43. Structure and function of the 5HT2A/mGluR2 complex in schizophrenia
    Javier Gonzalez-Maeso; Fiscal Year: 2013
    ..We have discovered a new neuroreceptor complex that induces hallucinations in mouse, and is affected in schizophrenia brain...
  44. Anxiolytic Property of Atypical Antipsychotics
    Ming Li; Fiscal Year: 2009
    ..Although both groups show similar efficacy against psychosis (e.g., delusions, hallucinations), it is unclear whether atypicals as a class have intrinsic and superior benefits over typicals on symptoms ..
  45. Molecular biology of mesocortical and mesoaccumbens dopamine neurons
    JEFFREY EELLS; Fiscal Year: 2009
    ..or subcortical) dopamine neurotransmission contributing to positive symptoms of schizophrenia (paranoia, hallucinations, delusions, and bizarre behavior) and attenuated mesocortical dopamine neurotransmission affecting negative ..
  46. Pathophysiology of Auditory Hallucinations
    RALPH EDWARD HOFFMAN; Fiscal Year: 2013
    ..overall objective of this R01 grant renewal is to ascertain the pathophysiological basis of auditory/verbal hallucinations (AVHs) in patients with schizophrenia and schizoaffective disorder...
  47. Cognitive Control and Language Impairments in Schizophrenia
    Tamara Y Swaab; Fiscal Year: 2013
    ..Although hallucinations and delusions are the most salient symptoms of this disease, language abnormalities are among the most ..
  48. MOTION AND FORM PROCESSING IN EXTRASTRIATE VISUAL CORTEX
    Thomas D Albright; Fiscal Year: 2011
    ..events that underlie visual memory, imagery, dreaming and manifestations of perceptual disorders, such as hallucinations. Such information will ultimately aid in the treatment and prevention of neurological and neuropsychiatric ..
  49. Subtype Specific Agonists for D1-D5 Dopamine Receptors
    William Goddard; Fiscal Year: 2007
    ..Dopamine receptor antagonists have been developed to block hallucinations and delusions that occur in schizophrenic patients, whereas dopamine receptor agonists are effective in ..
  50. Antipsychotic Treatment Effects on Attention &Working Memory in Schizophrenia
    James L Reilly; Fiscal Year: 2013
    ..While advances in antipsychotic pharmacotherapy have resulted in important gains for treating symptoms of hallucinations and delusions, cognitive deficits have been far less responsive to standard treatments...
  51. Targeting Cortical Dynamics: Rational Design of Individualized Brain Stimulation
    Flavio Frohlich; Fiscal Year: 2013
    ..activity in the gamma frequency band (>30 Hz) in the cortex is implicated in psychiatric symptoms such as hallucinations, reduced sensory gating, and impaired cognitive control...
  52. Parenteral Hydration in Advanced Cancer Patients: A Randomized Controlled Trial
    Eduardo Bruera; Fiscal Year: 2009
    ..Dehydration can cause or aggravate symptoms such as fatigue, myoclonus, sedation, hallucinations and delirium...
  53. Post-transcriptional Regulation of Serotonin Receptors
    RONALD EMESON; Fiscal Year: 2006
    ..well as a wide variety of behaviors including sleep, appetite, pain perception, locomotion, thermoregulation, hallucinations, and sexual behavior...
  54. Evoked potentials and vulnerability to ketamine in mice.
    Steven Siegel; Fiscal Year: 2004
    ..The consequences of ketamine and PCP abuse include hallucinations, paranoia, disorganization and cognitive impairments...
  55. NEUROTOXIC HALLUCINOGENS: EFFECTS ON LEARNING
    John Harvey; Fiscal Year: 1992
    ..2,5- dimethoxy-4-methylamphetamine (DOM) produce changes in learning at doses required to produce reliable hallucinations in humans (1 and 50 Mu g/kg, respectively)...
  56. Farnesol Analogues as Novel Treatment of Alcoholism
    Jean Baptiste Roullet; Fiscal Year: 2005
    ..and include tremor, anxiety, autonomic hyperactivity (sweating, increased blood pressure, tachycardia), hallucinations, seizures and delirium tremens...
  57. CELLULAR BASIS OF BRAINSTEM PGO WAVE GENERATION
    Subimal Datta; Fiscal Year: 2000
    ..The phemomenology and neurochemistry of narcolepsy, cataplexy, excessive daytime sleepiness, hypnogogic hallucinations, depression and many other major psychiatric and neurological disorders may share some features of normal REM ..
  58. PCP RECEPTOR CLASSES: STRUCTURE & THERAPEUTIC ASPECTS
    MORDECHAI SOKOLOVSKY; Fiscal Year: 1990
    Phencyclidine (PCP), a major drug of abuse, elicits hallucinations and feelings of tranquility and can generate aggressive, violent behavior...
  59. GHB Tolerance and Dependence
    Cynthia Kuhn; Fiscal Year: 2006
    ..use, tolerance develops and a withdrawal syndrome can occur that is characterized by insomnia, anxiety, and hallucinations. Tolerance and dependence to GHB are poorly characterized in animal models...
  60. EPILEPSY AS A NEUROLOGICAL MODEL OF SCHIZOPHRENIA
    Laura Marsh; Fiscal Year: 2000
    ..hypotheses will be tested: Hypothesis 1: ESZ and ISZ will demonstrate similar profiles of positive symptoms (hallucinations, delusions, and thought disorder) and negative symptoms (e.g...
  61. Dopamine and choline transporter imaging in DLB & AD
    ERIC PETRIE; Fiscal Year: 2009
    ..function, and yisuospatial/praxis skills;ii) parkinsonian motor signs;and iii) persistent visual hallucinations. Differences in striatal dopaminergic and cortical cholinergic neuron integrity have been implicated in the ..
  62. BRAINSTEM CHOLINERGIC NEUROANATOMY AND NEUROPHYSIOLOGY
    Priyattam Shiromani; Fiscal Year: 1991
    ..are excessive daytime sleepiness, sleep attacks, frequent and sudden attacks of cataplexy, and hypnagogic hallucinations. The disease appears to be a disorder of REM sleep because some narcoleptic symptoms are components of REM ..
  63. DNA EXPANSION IN SCHIZOPHRENIA
    Cynthia McMurray; Fiscal Year: 2000
    ..abstract): Schizophrenia is a severe disorder characterized by psychotic symptoms such as delusions and hallucinations and/or debilitating behavioral symptoms...