memory disorders

Summary

Summary: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.

Top Publications

  1. ncbi Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
    Holly Oakley
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 26:10129-40. 2006
  2. ncbi The endophenotype concept in psychiatry: etymology and strategic intentions
    Irving I Gottesman
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55454, USA
    Am J Psychiatry 160:636-45. 2003
  3. ncbi Neurocognitive deficit in schizophrenia: a quantitative review of the evidence
    R W Heinrichs
    Department of Psychology, York University, Toronto, Ontario, Canada
    Neuropsychology 12:426-45. 1998
  4. ncbi Deciphering the molecular basis of memory failure in Alzheimer's disease
    Dominic M Walsh
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Neuron 44:181-93. 2004
  5. ncbi Cognitive impairment in multiple sclerosis
    Nancy D Chiaravalloti
    Neuropsychology and Neuroscience Laboratory, Kessler Medical Rehabilitation Research and Education Center, West Orange, NJ 07052, USA
    Lancet Neurol 7:1139-51. 2008
  6. ncbi A role for adult neurogenesis in spatial long-term memory
    J S Snyder
    Department of Physiology, University of Toronto, 1 King s College Circle, Room 3214, Toronto, Ontario, Canada M5S 1A8
    Neuroscience 130:843-52. 2005
  7. ncbi Altered histone acetylation is associated with age-dependent memory impairment in mice
    Shahaf Peleg
    Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str 5, D 37077 Goettingen, Germany
    Science 328:753-6. 2010
  8. ncbi Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Vic, Australia
    J Affect Disord 113:1-20. 2009
  9. pmc Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:20822-7. 2010
  10. ncbi Inhibition of neurogenesis interferes with hippocampus-dependent memory function
    Gordon Winocur
    Department of Psychology, Trent University, Peterborough, Ontario
    Hippocampus 16:296-304. 2006

Detail Information

Publications343 found, 100 shown here

  1. ncbi Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
    Holly Oakley
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 26:10129-40. 2006
    ..Thus, 5XFAD mice rapidly recapitulate major features of AD amyloid pathology and may be useful models of intraneuronal Abeta42-induced neurodegeneration and amyloid plaque formation...
  2. ncbi The endophenotype concept in psychiatry: etymology and strategic intentions
    Irving I Gottesman
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55454, USA
    Am J Psychiatry 160:636-45. 2003
    ..The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics...
  3. ncbi Neurocognitive deficit in schizophrenia: a quantitative review of the evidence
    R W Heinrichs
    Department of Psychology, York University, Toronto, Ontario, Canada
    Neuropsychology 12:426-45. 1998
    ..The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests...
  4. ncbi Deciphering the molecular basis of memory failure in Alzheimer's disease
    Dominic M Walsh
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Neuron 44:181-93. 2004
    ..Accordingly, attempts to slow memory and cognitive loss by decreasing cerebral Abeta levels have entered human trials...
  5. ncbi Cognitive impairment in multiple sclerosis
    Nancy D Chiaravalloti
    Neuropsychology and Neuroscience Laboratory, Kessler Medical Rehabilitation Research and Education Center, West Orange, NJ 07052, USA
    Lancet Neurol 7:1139-51. 2008
    ..Moreover, examination of efforts to treat the cognitive deficits in MS is still in the early stages...
  6. ncbi A role for adult neurogenesis in spatial long-term memory
    J S Snyder
    Department of Physiology, University of Toronto, 1 King s College Circle, Room 3214, Toronto, Ontario, Canada M5S 1A8
    Neuroscience 130:843-52. 2005
    ..These results suggest a new role for adult neurogenesis in the formation and/or consolidation of long-term, hippocampus-dependent, spatial memories...
  7. ncbi Altered histone acetylation is associated with age-dependent memory impairment in mice
    Shahaf Peleg
    Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str 5, D 37077 Goettingen, Germany
    Science 328:753-6. 2010
    ..Our data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the aging mouse brain...
  8. ncbi Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Vic, Australia
    J Affect Disord 113:1-20. 2009
    ..Our aim was to delineate neuropsychological deficits related to genetic susceptibility, illness process and iatrogenic factors in bipolar disorder (BD)...
  9. pmc Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:20822-7. 2010
    ..Together, the data suggest that clinical dementia in Danish patients occurs via a loss of function mechanism and not as a result of amyloidosis and tauopathy...
  10. ncbi Inhibition of neurogenesis interferes with hippocampus-dependent memory function
    Gordon Winocur
    Department of Psychology, Trent University, Peterborough, Ontario
    Hippocampus 16:296-304. 2006
    ....
  11. ncbi The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease
    Marcus A Westerman
    Department of Neurology, Center for Clinical and Molecular Neurobiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 22:1858-67. 2002
    ..These studies also provide a methodological framework within which to investigate these Abeta assemblies in vivo...
  12. ncbi Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities
    Alena Savonenko
    Department of Pathology, Johns Hopkins School of Medicine, Ross Building, Room 558, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Neurobiol Dis 18:602-17. 2005
    ....
  13. pmc Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes
    Shuko Takeda
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 107:7036-41. 2010
    ..Cerebrovascular changes and alteration in brain insulin signaling might play a pivotal role in this relationship. These findings could provide insights into this intensely debated association...
  14. pmc Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment
    Inga Kadish
    Department of Cell Biology, University of Alabama, Birmingham, Alabama 35294, USA
    J Neurosci 29:1805-16. 2009
    ..These processes may damage structure and compete with neuronal pathways for bioenergetic resources, thereby impairing cognitive function...
  15. ncbi Memory impairment in schizophrenia: a meta-analysis
    A Aleman
    Psychological Laboratory, Utrecht University, The Netherlands
    Am J Psychiatry 156:1358-66. 1999
    ..In this article, the authors presented meta-analyses of the published literature on recall and recognition memory performance between patients with schizophrenia and normal comparison subjects...
  16. ncbi Peripheral infection and aging interact to impair hippocampal memory consolidation
    Ruth M Barrientos
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Neurobiol Aging 27:723-32. 2006
    ..It is possible that this cognitive vulnerability is mediated by age-related changes in the glial environment that results in an exaggerated brain pro-inflammatory response to infection...
  17. ncbi Mild cognitive impairment, amnestic type: an epidemiologic study
    Mary Ganguli
    Division of Geriatrics and Neuropsychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 63:115-21. 2004
    ..To estimate the prevalence and examine the course of mild cognitive impairment (MCI), amnestic type, using current criteria, within a representative community sample...
  18. ncbi Visual short-term memory binding deficits in familial Alzheimer's disease
    Mario A Parra
    Psychology Department, University of Edinburgh, 7 George Square, Edinburgh, UK
    Brain 133:2702-13. 2010
    ..This suggests that visual short-term memory binding deficits may be a preclinical marker for familial Alzheimer's disease...
  19. ncbi Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Anesthesiology 100:309-14. 2004
    ..This experiment was designed to test the hypothesis that learning of new information is particularly susceptible to prolonged disruption after general anesthesia...
  20. ncbi Unilateral temporal lobectomy patients show lateralized topographical and episodic memory deficits in a virtual town
    H J Spiers
    The Institute of Cognitive Neuroscience and the Department of Anatomy and Developmental Biology, University College London, London, UK
    Brain 124:2476-89. 2001
    ....
  21. pmc CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease
    Antonella Caccamo
    Department of Physiology, and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 107:22687-92. 2010
    ....
  22. pmc APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant
    Robert Tamayev
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
    EMBO J 30:2501-9. 2011
    ..This evidence establishes a pathogenic sameness between familial Danish and Alzheimer's dementias...
  23. ncbi Stress, depression, and neuroplasticity: a convergence of mechanisms
    Christopher Pittenger
    Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT 6508, USA
    Neuropsychopharmacology 33:88-109. 2008
    ..Greater appreciation of the convergence of mechanisms between stress, depression, and neuroplasticity is likely to lead to the identification of novel targets for more efficacious treatments...
  24. ncbi Double dissociation between the effects of peri-postrhinal cortex and hippocampal lesions on tests of object recognition and spatial memory: heterogeneity of function within the temporal lobe
    Boyer D Winters
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 24:5901-8. 2004
    ..These results provide strong evidence in favor of heterogeneity and independence of function within the temporal lobe...
  25. pmc Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease
    Steven J Greco
    Neurotez, Inc, Bridgewater, NJ 08807, USA
    J Alzheimers Dis 19:1155-67. 2010
    ..These findings solidly demonstrate the potential for leptin as a disease modifying therapeutic in transgenic animals of AD, driving optimism for its safety and efficacy in humans...
  26. pmc Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation
    Jae Woong Lee
    College of Pharmacy and CBITRC, Chungbuk National University 12, Cheongju, Chungbuk, Korea
    J Neuroinflammation 5:37. 2008
    ..Intracellular accumulation of beta-amyloid peptide (Abeta) has also shown to occur in AD. Neuro-inflammation has been known to play a role in the pathogenesis of AD...
  27. pmc Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: evidence for a dual-process memory model
    David J Sanderson
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    Learn Mem 16:379-86. 2009
    ..Thus, these results support a dual-process model of memory in which short-term and long-term memory are separate and sometimes competitive processes...
  28. pmc Memory disorders associated with consumption of drugs: updating through a case/noncase study in the French PharmacoVigilance Database
    François Chavant
    CHU de Poitiers, Service de Pharmacologie clinique et Vigilances, Centre Régional de PharmacoVigilance et de Renseignement sur les Médicaments, Poitiers, France
    Br J Clin Pharmacol 72:898-904. 2011
    To investigate putative associations of reports of memory disorders and suspected drugs.
  29. ncbi Adolescent exposure to nicotine and/or the cannabinoid agonist CP 55,940 induces gender-dependent long-lasting memory impairments and changes in brain nicotinic and CB(1) cannabinoid receptors
    B Mateos
    Department of Physiology Animal Physiology II, Faculty of Biology, Complutense University, Madrid, Spain
    J Psychopharmacol 25:1676-90. 2011
    ..The results show gender-dependent harmful effects of both drugs and long-lasting changes in CB(1) and nicotinic receptors...
  30. ncbi Phospholipase A₂: the key to reversing long-term memory impairment in a gastropod model of aging
    Shawn N Watson
    Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, Alberta, Canada
    Neurobiol Aging 34:610-20. 2013
    ..This supports the view that these processes suspend rather than irreversibly extinguish the aging nervous system's intrinsic capacity for plasticity...
  31. ncbi Effects of a 4 month enriched environment on the hippocampus and the myelinated fibers in the hippocampus of middle-aged rats
    Xuan Qiu
    Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine, Ministry of Education, Chongqing Medical University, Chongqing 400016, PR China
    Brain Res 1465:26-33. 2012
    ..The present study might provide an important theoretical basis for searching for an ethological strategy to delay the progress of brain aging in the future...
  32. pmc Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis
    Do Young Kim
    Barrow Neurological Institute, Medical Center, St Joseph s Hospital, Phoenix, Arizona, United States of America
    PLoS ONE 7:e35476. 2012
    ....
  33. pmc Retinoic acid restores adult hippocampal neurogenesis and reverses spatial memory deficit in vitamin A deprived rats
    Emilie Bonnet
    Nutrition and Neurosciences laboratory, University of Bordeaux 1, Talence, France
    PLoS ONE 3:e3487. 2008
    ....
  34. ncbi Prospective memory function in mild cognitive impairment and early dementia
    Claire Thompson
    School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia
    J Int Neuropsychol Soc 16:318-25. 2010
    ..It is suggested that, while other cognitive deficits contribute to these difficulties, there is something unique to prospective remembering that may be additionally disrupted in these groups...
  35. ncbi The nature and frequency of cognitive deficits in children with neurofibromatosis type 1
    Shelley L Hyman
    Neurogenetics Research Unit, Children s Hospital at Westmead, Australia
    Neurology 65:1037-44. 2005
    ..To assess the frequency and severity of specific cognitive deficits in children with neurofibromatosis type 1 (NF1) in a large unbiased cohort...
  36. ncbi High altitude memory impairment is due to neuronal apoptosis in hippocampus, cortex and striatum
    Panchanan Maiti
    Neurobiology Division, Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Ministry of Defence, Government of India, Lucknow Road, Timarpur, Delhi 110054, India
    J Chem Neuroanat 36:227-38. 2008
    ..Our result suggests that the apoptotic death may be involved in HA-induced memory impairment and after 7 days of exposure the effect was more pronounced but after 21 days of exposure recovery was observed...
  37. ncbi Transgenic mice with chronic NGF deprivation and Alzheimer's disease-like pathology display hippocampal region-specific impairments in short- and long-term plasticities
    Gry Houeland
    Laboratory of Molecular Mechanisms of Synaptic Plasticity, European Brain Research Institute, 00143 Rome, Italy
    J Neurosci 30:13089-94. 2010
    ....
  38. ncbi PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus
    Li Ying Jiang
    Department of Pharmacology, China Pharmaceutical University, Nanjing, China Department of Pharmacy, the Second Hospital Affiliated to Anhui Medical University, Hefei, China
    CNS Neurosci Ther 18:659-66. 2012
    ..Here, we investigated the effects of pioglitazone on memory impairment in a mouse model with defects in insulin sensitivity and secretion, namely high-fat diet (HFD) streptozotocin (STZ)-induced diabetic mice...
  39. ncbi Structural dissociation of attentional control and memory in adults with and without mild traumatic brain injury
    Sumit N Niogi
    Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY, USA
    Brain 131:3209-21. 2008
    ..More generally, such findings suggest that diffusion anisotropy measurement can be used as a quantitative biomarker for neurocognitive function and dysfunction...
  40. pmc Exercise and time-dependent benefits to learning and memory
    N C Berchtold
    Institute for Memory Impairment and Neurobiological Disorders, University of California, Irvine, CA 92697 4545, USA
    Neuroscience 167:588-97. 2010
    ....
  41. ncbi Prevalence of very mild and mild dementia in community-dwelling older Chinese people in Hong Kong
    Linda C W Lam
    Department of Psychiatry, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, The People s Republic of China
    Int Psychogeriatr 20:135-48. 2008
    ..In this report, the results of a household survey were used to examine the prevalence of very mild and mild dementia in Chinese older persons in Hong Kong...
  42. pmc High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
    Lakshmi Thirumangalakudi
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurochem 106:475-85. 2008
    ..The findings link hypercholesterolemia with cognitive dysfunction potentially mediated by increased neuroinflammation and APP processing in a non-transgenic mouse model...
  43. ncbi Alteration of CREB phosphorylation and spatial memory deficits in aged 129T2/Sv mice
    Yves Porte
    Laboratoire de Neurosciences Cognitives, CNRS UMR5228, Universite de Bordeaux 1, Avenue des Facultes, 33405 Talence Cedex, France
    Neurobiol Aging 29:1533-46. 2008
    ..Since reduced pCREB-ir in CA1 from the 15 min-aged group strongly correlated with individual learning performance, we suggest that altered CREB phosphorylation in CA1 may account for spatial memory impairments during normal aging...
  44. ncbi Genomic and proteomic strategies to identify novel targets potentially involved in learning and memory
    Charles Etienne Benoit
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Verdun, Quebec, Canada
    Trends Pharmacol Sci 32:43-52. 2011
    ..Examples of the possible functional role of some of these genes (e.g. transthyretin, quinone reductase 2) and gene products are discussed...
  45. pmc Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice
    Ryoichi Kimura
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, New York 10962, USA
    J Neurochem 113:248-61. 2010
    ..5XFAD mice. Therefore, our findings provide compelling evidence for beneficial effects of partially BACE1-inhibiting approaches on multiple forms of functional defects associated with AD...
  46. ncbi Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice
    Joseph F Quinn
    Portland Veterans Affairs Medical Center, P3 R and D Portland, OR, United States
    Neurobiol Aging 28:213-25. 2007
    ..These data indicate that chronic dietary ALA can reduce hippocampal-dependent memory deficits of Tg2576 mice without affecting beta-amyloid levels or plaque deposition...
  47. ncbi Prospective memory impairment in individuals with Parkinson's disease
    Alberto Costa
    Instituto di Ricovero e Cura a Carattere Scientifico IRCCS, Fondazione Santa Lucia, Rome, Italy
    Neuropsychology 22:283-92. 2008
    ..These results document that prospective memory is impaired in PD possibly in relation to a dysregulation of cognitive functions associated with frontal systems...
  48. ncbi The age-related attenuation in long-term potentiation is associated with microglial activation
    Rebecca Griffin
    Trinity College Institute for Neuroscience and Physiology Department, Trinity College, Dublin, Ireland
    J Neurochem 99:1263-72. 2006
    ..We propose that signs of neuroinflammation are observed in middle age and that these changes, which are characterized by microglial activation, may be triggered by IL-18...
  49. ncbi 4-O-methylhonokiol attenuated β-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase
    Yong Kyung Lee
    College of Pharmacy and MRC, Chungbuk National University, Heungduk gu, Cheongju, Chungbuk 361 763, South Korea
    J Nutr Biochem 22:476-86. 2011
    ..These results suggest that 4-O-MH might prevent the development and progression of AD through the reduction of oxidative stress and neuronal cell death via inactivation of p38 MAP kinase pathway...
  50. pmc Object recognition memory and BDNF expression are reduced in young TgCRND8 mice
    Beverly M Francis
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
    Neurobiol Aging 33:555-63. 2012
    ..Our findings suggest that object recognition provides an early index of cognitive impairment associated with amyloid exposure and reduced brain-derived neurotrophic factor expression in the TgCRND8 mouse...
  51. pmc Prominent hippocampal CA3 gene expression profile in neurocognitive aging
    Rebecca P Haberman
    Department of Psychological and Brain Science, The Johns Hopkins University, 3400 N Charles Street, 104 Ames Hall, Baltimore, MD 21218, United States
    Neurobiol Aging 32:1678-92. 2011
    ....
  52. ncbi Cognitive and cardiovascular benefits of docosahexaenoic acid in aging and cognitive decline
    K Yurko-Mauro
    Clinical Research, Martek Biosciences Corporation, Columbia, MD 21045, USA
    Curr Alzheimer Res 7:190-6. 2010
    ..Collectively, data reveal a potentially beneficial role for DHA in preventing or ameliorating cognitive decline and cardiovascular disease in the aged...
  53. ncbi Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice
    Maiko Satomoto
    Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Anesthesiology 110:628-37. 2009
    ..The authors investigated whether exposure of neonatal mice to inhaled sevoflurane causes deficits in social behavior as well as learning disabilities...
  54. ncbi (-)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency
    Young Kyoung Lee
    College of Pharmacy, Chungbuk National University 12, Heungduk gu, Cheongju, Chungbuk 361 763, Republic of Korea
    Brain Res 1250:164-74. 2009
    ....
  55. pmc Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient mice
    Virginie F Labrousse
    Psychoneuroimmunologie, Nutrition et Génétique PsyNuGen, INRA UMR 1286, CNRS UMR 5226, Universite de Bordeaux, Bordeaux, France
    PLoS ONE 4:e6006. 2009
    ..Taken together, our results show that P2X(7)R plays a critical role in spatial memory processes and the associated hippocampal IL-1beta mRNA synthesis and c-Fos activation...
  56. ncbi Subjective Memory Impairment. A review of its definitions indicates the need for a comprehensive set of standardised and validated criteria
    Khaled Abdulrab
    Medical School, University of Birmingham, Birmingham, UK
    Eur Psychiatry 23:321-30. 2008
    ..Subjective Memory Impairment (SMI) may hold value in the elderly as a predictor of dementia. There is yet to exist any standard definition of SMI for use in research or for clinical practice...
  57. ncbi Young hippocampal neurons are critical for recent and remote spatial memory in adult mice
    T Goodman
    Universite de Toulouse, UPS, Centre de Recherches sur la Cognition Animale, 118 route de Narbonne, F 31062 Toulouse Cedex 9, France
    Neuroscience 171:769-78. 2010
    ..Our findings provide additional evidence that generation of new cells in the adult brain is crucial for hippocampal-dependent cognitive functions...
  58. ncbi Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse
    Chris G Parsons
    Merz Pharmaceuticals, Eckenheimer Landstrasse 100, 60318 Frankfurt am Main, Germany
    Neuropharmacology 53:699-723. 2007
    ....
  59. ncbi Forgetting as an active process: an FMRI investigation of item-method-directed forgetting
    Glenn R Wylie
    Department of Physical Medicine and Rehabilitation Kessler Medical Rehabilitation Research and Education Center, West Orange, NJ 07052, USA
    Cereb Cortex 18:670-82. 2008
    ..These results challenge the standard selective rehearsal account of item-method directed forgetting and suggest that frontal control processes may be critical for directed forgetting...
  60. pmc Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
    Dun Sheng Yang
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Brain 134:258-77. 2011
    ..Our findings support the pathogenic significance of autophagic-lysosomal dysfunction in Alzheimer's disease and indicate the potential value of restoring normal autophagy as an innovative therapeutic strategy for Alzheimer's disease...
  61. ncbi Adaptive training leads to sustained enhancement of poor working memory in children
    Joni Holmes
    Division of Psychology, University of Northumbria, Newcastle upon Tyne, UK
    Dev Sci 12:F9-15. 2009
    ..Mathematical ability also improved significantly 6 months following adaptive training. These findings indicate that common impairments in working memory and associated learning difficulties may be overcome with this behavioral treatment...
  62. ncbi Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil
    Maha ElBeltagy
    Department of Anatomy, Menoufiya University, Egypt
    Behav Brain Res 208:112-7. 2010
    ..These findings suggest that 5-FU can negatively affect both cell proliferation and hippocampal dependent working memory and that these deficits can be reversed by the simultaneous administration of the antidepressant Fluoxetine...
  63. pmc Evaluating the relationship between memory functioning and cingulum bundles in acute mild traumatic brain injury using diffusion tensor imaging
    Trevor C Wu
    Department of Psychology, Brigham Young University, Provo, Utah, USA
    J Neurotrauma 27:303-7. 2010
    ..These preliminary findings indicate that cingulate injury likely contributes to the cognitive sequelae seen during the early phase post-mTBI...
  64. ncbi Are old adults just like low working memory young adults? Filtering efficiency and age differences in visual working memory
    Kerstin Jost
    Institute of Psychology, RWTH Aachen University, D 52066 Aachen, Germany
    Cereb Cortex 21:1147-54. 2011
    ..Thus, age and individual differences in filtering are reflected in different ways showing that old adults are not simply like less efficiently performing young adults...
  65. ncbi Amyloid-beta(25-35)-induced memory impairments correlate with cell loss in rat hippocampus
    Mikhail Yu Stepanichev
    Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5a Butlerov Str, Moscow 117485, Russia
    Physiol Behav 80:647-55. 2004
    ..These data suggest the involvement of oxidative stress in Abeta(25-35)-induced neurodegeneration and a relation between memory impairment and neurodegeneration in the CA1 subfield of the hippocampus...
  66. ncbi Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics
    Thomas W McAllister
    Section of Neuropsychiatry, Neuropsychology Program, Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Neurotrauma 23:1450-67. 2006
    ..We review the evidence from fMRI and neurogenetic studies that support the role of catecholaminergic dysregulation in the etiology of WM complaints and deficits after mild and moderate TBI...
  67. ncbi Evidence for excessive frontal evoked gamma oscillatory activity in schizophrenia during working memory
    M S Barr
    Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    Schizophr Res 121:146-52. 2010
    ..These findings may provide important insights into the pathophysiology underlying WM deficits, its relationship to negative symptoms and may represent a potential neurobiological marker for cognitive enhancing strategies in SCZ...
  68. ncbi Mild cognitive impairment as a clinical entity and treatment target
    Ronald C Petersen
    Alzheimer s Disease Research Center, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Arch Neurol 62:1160-3; discussion 1167. 2005
  69. pmc eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation
    Zhihong Jiang
    Unit on the Genetics of Cognition and Behavior, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:2582-94. 2010
    ..The present study sheds light on the critical importance of gene-specific translations for hippocampal memory consolidation...
  70. ncbi Memory outcome after selective amygdalohippocampectomy: a study in 140 patients with temporal lobe epilepsy
    Ulrike Gleissner
    University Hospital of Epileptology, Bonn, Germany
    Epilepsia 43:87-95. 2002
    ..The results of previous studies, however, are equivocal in this regard. This study evaluated memory after SAH in a large sample of patients with mesial temporal lobe epilepsy...
  71. pmc Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles
    Jeffrey D Riley
    Department of Neurology, University of California, Irvine, CA 92868, USA
    Epilepsia 51:536-45. 2010
    ..However, limited data exist regarding the extent of white matter tract abnormalities, cognitive effects of these abnormalities, and relationship to clinical factors. The current study examined these issues in subjects with chronic TLE...
  72. ncbi Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptor inverse agonist L-655,708
    Bechara J Saab
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Anesthesiology 113:1061-71. 2010
    ..We postulated that inhibiting the activity of α5GABAA receptors during isoflurane anesthesia would prevent memory deficits in the early postanesthesia period...
  73. ncbi Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS
    Alexander Fleischmann
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    J Neurosci 23:9116-22. 2003
    ..In summary, our data suggest a role for c-Fos in hippocampus-dependent learning and memory as well as in NMDA receptor-dependent LTP formation...
  74. ncbi Vitamin A deficiency and relational memory deficit in adult mice: relationships with changes in brain retinoid signalling
    Nicole Etchamendy
    CNRS UMR 5106, Lab Neurosciences Cognitives, Universite de Bordeaux 1, Avenue des Facultes, 33405 Talence Cedex, France
    Behav Brain Res 145:37-49. 2003
    ....
  75. ncbi Impairment of long-term associative memory in aging snails (Lymnaea stagnalis)
    Petra M Hermann
    Department of Biological Sciences, Faculty of Science, University of Calgary, Alberta, Canada
    Behav Neurosci 121:1400-14. 2007
    ..Together, these results present the Lymnaea feeding system as a powerful paradigm for investigations of cellular and molecular foundations of biological aging in the brain...
  76. ncbi Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway
    Paula M Canas
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    J Neurosci 29:14741-51. 2009
    ....
  77. ncbi Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats
    Swapnil Sonkusare
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S A S Nagar 160062, Punjab, India
    Life Sci 77:1-14. 2005
    ..3 mg/kg) showed significant improvement in memory. When administered together, the effect of combination of these two drugs on memory and cholinesterase activity was higher than that obtained with either of the drugs when used alone...
  78. ncbi Sex differences in chronic stress effects on memory in rats
    Victoria Luine
    Department of Psychology, Hunter College of the City University of New York, NY 10021, USA
    Stress 5:205-16. 2002
    ..Nonetheless, recent studies show sexually differentiated cognitive responses to chronic stress and underline the importance of considering the sex/gender of subjects when studying the stress response...
  79. ncbi Effects of early seizures on later behavior and epileptogenicity
    Gregory L Holmes
    Neuroscience Center at Dartmouth, Section of Neurology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Ment Retard Dev Disabil Res Rev 10:101-5. 2004
    ..These changes occur in the absence of cell loss. Although impaired cognitive function and brain changes have been well-documented following early-onset seizures, the mechanisms of seizure-induced dysfunction remain unclear...
  80. pmc Age-related changes in Arc transcription and DNA methylation within the hippocampus
    M R Penner
    ARL Division of Neural Systems, Memory and Aging and Evelyn F McKnight Brain Institute, University of Arizona, Tucson, AZ 85724, USA
    Neurobiol Aging 32:2198-210. 2011
    ..Given that Arc is necessary for normal memory function, these subregion-specific epigenetic and transcriptional changes may result in less efficient memory storage and retrieval during aging...
  81. pmc Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits
    Celine Ullrich
    Laboratory of Psychiatry and Exp Alzheimers Research, Department of Psychiatry and Psychotherapy, Innsbruck Medical University, Austria
    Mol Cell Neurosci 45:408-17. 2010
    ....
  82. ncbi Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats
    Greg Stratmann
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143, USA
    Anesthesiology 110:834-48. 2009
    ..Postnatal hippocampal neurogenesis affects hippocampal function into adulthood; therefore, the authors tested the hypothesis that isoflurane affects long-term neurocognitive function via an effect on dentate gyrus neurogenesis...
  83. ncbi l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways
    Tae Il Kim
    College of Pharmacy and CBITRC, Chungbuk National University, Cheongju, Chungbuk 361 763, Korea
    Free Radic Biol Med 47:1601-10. 2009
    ..Thus, l-theanine may be useful in the prevention and treatment of AD...
  84. ncbi Chronic nicotine restores normal Aβ levels and prevents short-term memory and E-LTP impairment in Aβ rat model of Alzheimer's disease
    Marisa Srivareerat
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, United States
    Neurobiol Aging 32:834-44. 2011
    ..Furthermore, chronic nicotine treatment prevented the Aβ-induced reduction of α(7)- and α(4)-nAChR. These effects of nicotine may be due, at least in part, to upregulation of brain derived neurotropic factor (BDNF)...
  85. pmc Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly
    Antonio Convit
    Center for Brain Health, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 100:2019-22. 2003
    ..This observation may bring to light a mechanism for aging brain injury that may have substantial medical impact, given the large number of elderly individuals with impaired glucose metabolism...
  86. ncbi The effects of clozapine and risperidone on spatial working memory in schizophrenia
    Susan R McGurk
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029, USA
    Am J Psychiatry 162:1013-6. 2005
    ..The purpose of this investigation was to evaluate the effects of clozapine and risperidone on spatial working memory in patients with schizophrenia...
  87. ncbi Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophy
    R H B Benedict
    Jacobs Neurological Institute, Buffalo Neuroimaging Analysis Center, and Department of Neurology, State University of New York at Buffalo, New York 14203, USA
    J Neurol Neurosurg Psychiatry 80:201-6. 2009
    ..However, the importance of mesial temporal lobe (MTL) atrophy in MS is largely untested and poorly understood. New structural imaging techniques permit volumetric measures of multiple regions within the MTL lobe and DGM...
  88. ncbi Does 'errorless learning' compensate for neurocognitive impairments in the work rehabilitation of persons with schizophrenia?
    R S Kern
    UCLA Department of Psychiatry and Biobehavioral Sciences and Department of Veteran s Affairs VISN 22 Mental Illness Research Education and Clinical Center MIRECC, Los Angeles, CA 90073, USA
    Psychol Med 33:433-42. 2003
    ..Procedures based on errorless learning may facilitate work rehabilitation because they effectively automate training of work and other skills, thereby reducing the cognitive burden on persons with schizophrenia...
  89. ncbi Verbal memory in mesial temporal lobe epilepsy: beyond material specificity
    Michael M Saling
    School of Behavioural Science, Redmond Barry Building, The University of Melbourne, 3010 Victoria, Australia
    Brain 132:570-82. 2009
    ..Impairment of this fundamental memory system is a proximal neurocognitive marker of mesial temporal epileptogenesis...
  90. pmc Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease
    Cynthia A Massaad
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:13576-81. 2009
    ..These findings directly link mitochondrial superoxide to AD pathology and demonstrate the beneficial effects of a mitochondrial anti-oxidant enzyme, hence offering significant therapeutic implications for AD...
  91. ncbi Reductions of acetylcholine release and nerve growth factor expression are correlated with memory impairment induced by interleukin-1beta administrations: effects of omega-3 fatty acid EPA treatment
    Pornnarin Taepavarapruk
    Department of Biomedical Sciences, AVC, University of Prince Edward Island, Charlottetown PEC1A4P3, Canada
    J Neurochem 112:1054-64. 2010
    ..This study revealed important mechanisms by which IL-1beta impairs, while E-EPA improves memory through IL-1-glucocorticoid-ACh release and IL-1-NGF-ACh release pathways...
  92. ncbi Cortisol-induced impairments of working memory require acute sympathetic activation
    Bernet M Elzinga
    Section of Clinical and Health Psychology, University of Leiden, Leiden, Netherlands
    Behav Neurosci 119:98-103. 2005
    ..These findings suggest that adrenergic activation is essential for the impairing effects of stress-induced cortisol on working memory...
  93. ncbi Long-term improvements in cognitive performance through computer-assisted cognitive training: a pilot study in a residential home for older people
    V K Günther
    Clinical Psychology Unit, Department of Psychiatry, Innsbruck University Hospital, Austria
    Aging Ment Health 7:200-6. 2003
    ..It is suggested that computers could be employed more extensively to prevent and treat cognitive deficits in older people...
  94. ncbi A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats
    Julien Detour
    INSERM U398, Faculty of Medicine, Strasbourg, France
    Epilepsia 46:499-508. 2005
    ..In temporal lobe epilepsy (TLE), interictal behavioral disorders affect patients' quality of life. Therefore we studied long-term behavioral impairments in the lithium-pilocarpine (li-pilo) model of TLE...
  95. ncbi A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    D Morgan
    Department of Pharmacology, University of South Florida, Tampa 33612, USA
    Nature 408:982-5. 2000
    ..The A beta-vaccinated mice also had a partial reduction in amyloid burden at the end of the study. This therapeutic approach may thus prevent and, possibly, treat Alzheimer's dementia...
  96. ncbi CREB, synapses and memory disorders: past progress and future challenges
    Sheena A Josselyn
    Program in Integrative Biology and Brain and Behaviour, Hospital for Sick Children Research Institute, 555 University Ave, Toronto, ON, Canada M5G 1X8
    Curr Drug Targets CNS Neurol Disord 4:481-97. 2005
    ..Therefore, we explore the possibility of targeting CREB function in developing novel treatment strategies. Finally, we highlight areas of research on CREB that are ripe for further advancement...
  97. ncbi Verbal episodic memory impairment in Alzheimer's disease: a combined structural and functional MRI study
    Florence Remy
    MR Technology, Institute for Biodiagnostics, National Research Council, Winnipeg, Canada
    Neuroimage 25:253-66. 2005
    ..During episodic Recognition, these functional changes may closely correlate with the progressive structural changes observed in the hippocampal region...
  98. pmc Senescent synapses and hippocampal circuit dynamics
    Sara N Burke
    Evelyn F McKnight Brain Institute, University of Arizona, Tucson, AZ 85724, USA
    Trends Neurosci 33:153-61. 2010
    ....
  99. ncbi Memory impairment in patients with late-onset major depression: the effect of antidepressant therapy
    Roberto Gallassi
    Centre for the Neurological Study of Cerebral Aging, Department of Neurological Sciences, University of Bologna, Italy
    J Affect Disord 91:243-50. 2006
    ..Cognitive deficits have been described in patients with major depression (MD), although many aspects remain unsettled...
  100. pmc A neural coding scheme formed by the combined function of gamma and theta oscillations
    John Lisman
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
    Schizophr Bull 34:974-80. 2008
    ..The same coding scheme may be used in certain cortical regions to encode multi-item short-term memory. The possibility that abnormalities in theta/gamma could underlie symptoms of schizophrenia is discussed...
  101. ncbi Relationship between distressing cancer-related recollections and hippocampal volume in cancer survivors
    Tomohito Nakano
    Psycho Oncology Division, National Cancer Center Research Institute East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Am J Psychiatry 159:2087-93. 2002
    ..The aim of this study was to determine whether there is a similar association between distressing cancer-related recollections and hippocampal volume...

Research Grants81

  1. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
    ..This will be tested by comparing behavior and brain health in several mouse groups including: A( vaccinated (alone) and those treated with lovastatin plus A( vaccination. ..
  2. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The number of patients in the United States afflicted with learning and memory disorders is rapidly increasing...
  3. Canonical Transient Receptor Potential (TRPC) subfamily function in Hippocampus.
    David E Clapham; Fiscal Year: 2013
    ....
  4. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..This latter research may also have implications in Alzheimer's disease and schizophrenia. ..
  5. Synaptic autoimmunity in disorders of memory, behavior, cognition and psychosis
    Josep Dalmau; Fiscal Year: 2010
    ....
  6. BDNF-Estrogen Interactions with Perimenopausal Mood and Cognition
    Elizabeth M Waters; Fiscal Year: 2012
    ..this proposal will test the central hypothesis that a single copy of Val66Met allele intensifies the mood and memory disorders seen during perimenopause and leads to disruption of BDNF signaling mediated by estrogen in the hippocampus...
  7. BRAIN LIPID METABOLISM, DENDRITES AND SYNAPSES IN AGING AND ALZHEIMER'S DISEASE
    Guojun Bu; Fiscal Year: 2013
    ..Our studies may also define apoE and apoE receptors as critical targets for AD therapy. ..
  8. Small-molecule probes of chromatin-mediated neuroplasticity
    Stephen J Haggarty; Fiscal Year: 2013
    ..the role that gene expression plains in mediating aspects of brain plasticity relevant to mood and memory disorders using small molecules as probes in biochemical and mouse behavioral studies...
  9. Cognitive Complaints and Decline and B-Amyloid Deposition in Non-Demented Elderly
    BETH ELLEN SNITZ; Fiscal Year: 2013
    ..implementation of a complete, original PiB-PET study of cognitively normal participants self-referred to a Memory Disorders Clinic, as well as the step-wise development, refinement and validation of a new scale for subjective ..
  10. The Role of Intracellular Metabotropic Glutamate Receptor 5 at the Synapse
    CAROLYN ANN PURGERT; Fiscal Year: 2012
    ..is implicated in a variety of neurological problems including anxiety, seizures, addiction, learning and memory disorders, and Fragile X Syndrome (FXS)...
  11. Novel Hsp90 Inhibitors to Reduce Misfolded Proteins in Alzheimer's Disease
    Mary L Michaelis; Fiscal Year: 2011
    ..Successful completion of this program will advance this concept toward clinical development. ..
  12. Comparative effectiveness of Brain Imaging and Blood Biomarkers in Alzheimer??s d
    Orly Lazarov; Fiscal Year: 2010
    ....
  13. Oxidative stress in a murine model of sleep apnea
    David Gozal; Fiscal Year: 2012
    ..Given the increasing prevalence of both OSAS and obesity in our society, it is therefore imperative to identify the underlying factors that contribute to the adverse behavioral outcomes associated with the disease. ..
  14. SK2 Channels as Novel Neuroprotective Targets Against Cerebral Ischemia
    Paco S Herson; Fiscal Year: 2012
    ....
  15. Effect of White Matter Disease on Gait and Balance in Cerebral Amyloid Angiopathy
    Anand Viswanathan; Fiscal Year: 2013
    ..The applicant is attached to both the MGH Stroke Service and the MGH Memory Disorders Unit (MDU)...
  16. GABA-A Receptor Pharmacology of Neural Coding in Hippocampal Place Cells
    TARA MONIQUE STEWART; Fiscal Year: 2012
    ..abstract_text> ..
  17. Genetic Susceptibility to PCB-induced Motor Dysfunction
    CHRISTINE PERDAN CURRAN; Fiscal Year: 2012
    ..The proposed research is designed to identify neural pathways affected by PCB exposure and humans at highest risk of PCB developmental neurotoxicity using a mouse model that mirrors known genetic variations in humans. ..
  18. Epigenomic impact of diet and toxicant exposure in Alzheimers disease etiology
    Iliya Lefterov; Fiscal Year: 2013
    ....
  19. Novel epigenetic mechanisms in neuronal development and cognitive function
    Jun Xu; Fiscal Year: 2013
    ..Taken together, the proposed studies will provide significant new insights into epigenetic mechanisms that control cognitive function and behavior, and, when go awry, cause debilitating human diseases such as MR. ..
  20. Defining the epitope in antiNMDA receptor encephalitis
    DAVID ROBINSON LYNCH; Fiscal Year: 2010
    ..Through understanding of this process, the proposal may facilitate therapies for preventing damage in this disorder and a basic understanding of other neurologic disorders such as stroke. ..
  21. Cortactin and Spine Dysfunction in Fragile X
    RONALD ROBERT SEESE; Fiscal Year: 2013
    ....
  22. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas C Foster; Fiscal Year: 2010
    ..The results of our experiments may provide the groundwork for future development of ER gene therapies to slow or prevent cognitive decline associated with aging and age- related diseases. ..
  23. Chromatin remodeling mechanisms of gene transcription in memory
    Farah D Lubin; Fiscal Year: 2013
    ....
  24. Vitamin C and cognition in Alzheimer's disease
    Fiona Edith Harrison; Fiscal Year: 2013
    ..It will also investigate the potential for vitamin C administration via parenteral routes, as a new therapeutic strategy. ..
  25. Intrinsic plasticity and information storage in cerebellar Purkinje cells
    CHRISTIAN ROBERT HANSEL; Fiscal Year: 2012
    ..mechanisms of (motor) learning and to develop novel modes for the treatment of motor learning deficits and memory disorders in general...
  26. Assessing the effects of Synj1 haploinsufficiency in Alzheimer's disease models
    Gilbert Di Paolo; Fiscal Year: 2010
    ..The goal of this proposal is to assess whether genetically decreasing the catabolism of PtdIns(4,5)P2 in the brain of AD mouse models can ameliorate learning and memory deficits in various behavioral tasks. ..
  27. Genetics of Parkinsonism in a Special Population of Untreated Schizophrenia
    Gabriel Alejandro De Erausquin; Fiscal Year: 2013
    ..Lastly, we anticipate that our research strategy may indicate new waysto study and address the increased vulnerability of schizophrenic patients to nicotine dependence. ..
  28. Diabetes, Cognition and the Brain
    Antonio Convit; Fiscal Year: 2012
    ..The goal of this research is to increase our understanding of how the brain is affected so as to be in a position to develop treatment strategies to try to protect the brain during diabetes. ..
  29. Pharmacokinetic and pharmacodynamic optimization of soluble Abeta oligomer recept
    Susan M Catalano; Fiscal Year: 2012
    ..Such an optimized IND Abeta oligomer receptor antagonist candidate would be among the first small molecule drugs to reverse AD and MCI symptoms and block disease progression. ..
  30. Memory, Thiamine Levels, and Brain Structure in Heart Failure
    MARY ANN WOO; Fiscal Year: 2010
    ....
  31. Effects of traumatic brain injury on hippocampal network activity: age difference
    Susanna Rosi; Fiscal Year: 2013
    ..These types of data are currently unavailable and are essential for the development of treatments and strategies to manage TBI- mediated neurocognitive dysfunctions. ..
  32. Suprachiasmatic Nucleus Output Pathway for Learning and Memory
    H Craig Heller; Fiscal Year: 2013
    ..Thus, a major benefit of this proposal is that the results will lead to a much needed animal model in which we can study circadian contributions to human pathologies that are of interest to clinicians. ..
  33. The Role of DNA Demethylation by Gadd45b in Memory and Synaptic Plasticity
    FARAZ ALI SULTAN; Fiscal Year: 2013
    ..Effective treatment of memory disorders is lacking, and novel pharmacological approaches are necessary...
  34. New Models to Assay Gene Silencing Therapies
    Ronald J Mandel; Fiscal Year: 2012
    ....
  35. Fibrinogen as a molecular mediator of cognitive dysfunction
    Frances Alexandra Loucks; Fiscal Year: 2010
    ..The identification of fibrinogen as a molecular mediator of cognitive dysfunction will establish the therapeutic potential of fibrinogen inhibitors to prevent cognitive dysfunction in the aging population. ..
  36. Group I Metabotropic Glutamate Receptors and Epileptogenesis
    Paul A Rutecki; Fiscal Year: 2013
    ..of traumatic brain injury and mild concussive injury in the development of post-traumatic stress disorder and memory disorders point to the importance of hippocampal dysfunction...
  37. BDNF and Spine-Realted Disorders of Memory and Cognition
    Christine M Gall; Fiscal Year: 2013
    ..In all, the proposed studies are expected to test for the presence of a final, common defect in memory disorders and to thoroughly evaluate a clinically relevant strategy for normalizing synaptic plasticity and behavior...
  38. Antisense Oligonucleotide Treatment for Alzheimer's Disease
    Susan A Farr; Fiscal Year: 2013
    ....
  39. Memory modulation by SK channels
    ROBERT WILLIAM STACKMAN; Fiscal Year: 2013
    ..These studies will also contribute to defining targets for novel therapies to combat impairments of memory that result from aging and neurological disorders, a well as treatments for fear and anxiety disorders. ..
  40. Modeling Schizophrenia with Altered Expression of Neuregulin 1 (Nrg1)
    NANCY MEIYUN CHIU BIVENS; Fiscal Year: 2013
    ..By more closely modeling the underlying pathology, mutant animal systems have the potential to accelerate the discovery of new preventative and therapeutic agents, as well as model gene by environment interactions. ..
  41. Proteomics of memory: Normal brain aging and Alzheimers Disease
    Catherine Cook Kaczorowski; Fiscal Year: 2013
    ..Robert Vassar at Northwestern University Medical School. Outcomes of the proposed research have the potential to make a major impact on the identification of new treatments for both aging and AD-related memory disorders.
  42. mTOR dysregulation in Epilepsy
    Angela N Carter; Fiscal Year: 2013
    ..We will employ a series of biochemical, pharmacological, neurophysiological and behavioral assays for these studies. ..
  43. Telecognitive Assessment: Extending Neuropsychology to Underserved Elders
    Munro Cullum; Fiscal Year: 2010
    ..controls and patients with mild to moderate Alzheimer's disease (AD) seen through the UT Southwestern Memory Disorders Unit, and we will field test these procedures in a rural Native American population at our satellite clinic ..
  44. Portion control lifestyle change to decrease obesity in persons with disabilities
    Mary E Segal; Fiscal Year: 2012
    ..If successful, this pilot will lead to a full-scale RCT to improve the health of persons with developmental disabilities. ..
  45. Role of Neuropeptide S in age-related cognitive decline
    Olivier Civelli; Fiscal Year: 2012
    ..The study is both exploratory and translational and could lead to a better understanding of neural mechanisms underlying cognitive aging. ..
  46. Small Molecule Oligomer Formation Inhibitors
    Susan M Catalano; Fiscal Year: 2010
    ..The project will result in a first-in-class oligomer formation inhibitor suitable for commercialization as a preclinical candidate. ..
  47. Pathology-directed combination therapy for pediatric TBI
    Ramesh Raghupathi; Fiscal Year: 2013
    ..abstract_text> ..
  48. AMPK in Alzheimer's Disease-Associated Synaptic Failure and Memory Deficits
    Tao Ma; Fiscal Year: 2013
    ..abstract_text> ..
  49. Proteomics of memory failure: unraveling the relationship between 'normal'brain
    Catherine Cook Kaczorowski; Fiscal Year: 2013
    ..Robert Vassar at Northwestern University Medical School. Outcomes of the proposed research have the potential to make a major impact on the identification of new treatments for both aging and AD-related memory disorders.
  50. Neuronal-Glial Dialogue and Cognition
    Carmelina Gemma; Fiscal Year: 2012
    ..Our contribution here is expected to be a detailed understanding of how FKN/CX3CR1 signaling defect in the aged brain leads to a decline in cognitive function. ..
  51. Signaling cascades and memory deficits during aging
    Thomas C Foster; Fiscal Year: 2013
    ..abstract_text> ..
  52. Genetic and behavioral analysis of developmental ethanol exposure in Drosophila
    KIMBERLY DEVON MCCLURE; Fiscal Year: 2010
    ....
  53. Protective Mechanisms of Statins in Alzheimer's Disease
    Ling Li; Fiscal Year: 2012
    ..Results from this project may lead to novel therapies to combat AD. ..
  54. SYNAPTIC SUBSTRATES OF AGE-DEPENDENT MEMORY DEFICITS
    John F Disterhoft; Fiscal Year: 2013
    ..Additionally, determining the nature and locus of deficient synaptic function in aged animals will facilitate the design of preventative measures intended to make aging more "succesful". ..
  55. High-resolution Functional Imaging of Hippocampal Subfields in Schizophrenia
    THEODORUS G M VAN ERP; Fiscal Year: 2013
    ....
  56. The age-dependence of synaptic deficits in 22q11.2 deletion syndrome mouse models
    Laurie R Earls; Fiscal Year: 2013
    ..The career development award would be an important step in establishing this research program. ..
  57. CRCNS: Modeling Activation of CaMKII in Spines
    Terrence J Sejnowski; Fiscal Year: 2013
    ..abstract_text> ..
  58. Aminopeptidases for Neurotoxic Pyroglutamate Beta-Amyloid of Alzheimers Disease
    Vivian Y H Hook; Fiscal Year: 2013
    ..Results will also yield candidate inhibitors of these aminopeptidases for future investigation of aminopeptidase regulation in Alzheimer's disease. ..
  59. Mechanisms of Memory Enhancement by Deep Brain Stimulation in Humans
    Itzhak Fried; Fiscal Year: 2013
    ..develop insight into the mechanisms of memory enhancement associated with DBS in humans, contribute to the understanding of the MTL and its role in memory, and ultimately provide novel therapeutic approaches to human memory disorders.
  60. Signaling pathway dysregulation in epilepsy
    Anne E Anderson; Fiscal Year: 2013
    ....
  61. Modeling Fragile X Syndrome in Drosophilia
    Thomas A Jongens; Fiscal Year: 2013
    ....
  62. Molecular Mechanisms of Alcohol Actions in the Adolescent Brain
    Jilla Sabeti; Fiscal Year: 2009
    ..These experiments will provide critical insights into the molecular mechanisms responsible for the age-dependent switch in the LTP-activated pathways elicited by ethanol exposure during the adolescent period of development. ..
  63. Remediation of Word Processing and Short-Term Memory Deficits in Aphasia
    Nadine Martin; Fiscal Year: 2009
    ..The efficacy of the treatment will be examined with probes of acquisition and maintenance in a multiple baseline across multiple stimuli design, and with comparisons of pre- and post-test ..
  64. Gene silencing of phosphodiesterase-4D (PDE4D) as a therapeutic approach to beta
    Han Ting Zhang; Fiscal Year: 2009
    ....
  65. Validation of Measures of Restless Legs Syndrome for Elders with Memory Disorders
    Kathy Richards; Fiscal Year: 2009
    ..Receiver Operator Curves will determine the best single or combination of instruments to diagnose RLS. ..
  66. REHABILITATION OF COGNITIVE SYMPTOMS IN MS
    John DeLuca; Fiscal Year: 2002
    ..Results of this project will have significant implications for the treatment of memory disorders in persons with MS...
  67. SLEEP MEMORY: A MOLECULAR AND GENETIC ANALYSIS
    EDWIN ABEL; Fiscal Year: 2002
    ..abstract_text> ..
  68. Novel therapeutics for learning and memory disorders
    Joseph Moskal; Fiscal Year: 2006
    ....
  69. Conditioning-specific reflex modification
    BERNARD SCHREURS; Fiscal Year: 2004
    ..how learning modifies behavior in order to develop preventive and therapeutic strategies for learning and memory disorders. The objective of this application is to characterize the behavioral laws and identify the potential neural ..
  70. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2003
    Insights into the processes of learning and memory have fundamental implications for understanding memory disorders such as occur during amnesia and Alzheimer's disease...
  71. BEHAVIORAL AND NEURONAL EFFECTS OF RETROVIRAL INFECTION
    Ian Paul; Fiscal Year: 1999
    ....
  72. Immunity to brain Ma proteins: A remote effect of cancer
    Josep Dalmau; Fiscal Year: 2007
    ..abstract_text> ..
  73. COMPUTER TRAINING FOR OLDER ADULTS
    Elizabeth Glisky; Fiscal Year: 1993
    ..One concerns the representation of newly-acquired knowledge in semantic memory and the other concerns the adequacy of a processing resources account of cognitive aging in explaining complex learning and transfer phenomenon...
  74. Neonatal Ethanol-Induced Memory Impairments in Rats
    Pamela Hunt; Fiscal Year: 2009
    ..The potential for amelioration of these cognitive deficits using both behavioral and pharmacological strategies will provide important information regarding treatment approaches for afflicted individuals. ..
  75. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2009
    ..The number of prenatally MA exposed children continues to grow. Our goal is to develop models of early MA exposure that permit an understanding of the long-term consequences on brain development and cognition. ..
  76. Cognitive Representation in Specific Language Impairment
    Julia L Evans; Fiscal Year: 2010
    ....
  77. WORKING MEMORY IN HUMAN BRAIN DAMAGE
    MARK D ESPOSITO; Fiscal Year: 1999
    ..These studies will improve our knowledge of working memory and provide a rational basis for diagnostic and therapeutic intervention in patients with working memory impairments. ..
  78. Neurophysiology of Working Memory in Bipolar Disorder
    Caleb Adler; Fiscal Year: 2007
    ..abstract_text> ..
  79. ETHANOL AND NMDA RECEPTOR FUNCTION
    RUEBEN GONZALES; Fiscal Year: 1999
    ..This information may lead to new therapeutic approaches for the treatment of alcohol related problems. ..
  80. STATUS EPILEPTICUS REORGANIZES CANNABINOID RECEPTORS
    ROBERT JOHN DELORENZO; Fiscal Year: 2010
    ..These studies may lead to the development of novel therapeutic interventions to reverse the effects of SE on AE and memory loss by pharmacologically regulating the endogenous CB1system. ..
  81. Ginkgo biloba for ECT-induced Memory Deficits
    JOHN MARKOWITZ; Fiscal Year: 2003
    ..will utilize larger groups and additional cognitive tests will be incorporated to provide more definitive conclusions regarding efficacy, optimal dose and duration, persistence of effects, and safety and tolerability ..