Summary: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Top Publications

  1. ncbi Predicting coma and other low responsive patients outcome using event-related brain potentials: a meta-analysis
    J Daltrozzo
    Department of Neurology, University Hospital of Strasbourg, France
    Clin Neurophysiol 118:606-14. 2007
  2. pmc Sequestration and microvascular congestion are associated with coma in human cerebral malaria
    Mark J Ponsford
    Nuffield Department of Clinical Laboratory Sciences, The John Radcliffe Hospital, University of Oxford, United Kingdom
    J Infect Dis 205:663-71. 2012
  3. ncbi Survival after treatment of rabies with induction of coma
    Rodney E Willoughby
    Department of Pediatric Infectious Diseases, Medical College of Wisconsin, Milwaukee, USA
    N Engl J Med 352:2508-14. 2005
  4. ncbi Differentiating the pathologies of cerebral malaria by postmortem parasite counts
    Terrie E Taylor
    Department of Internal Medicine, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Nat Med 10:143-5. 2004
  5. ncbi Systematic review of prediction of poor outcome in anoxic-ischaemic coma with biochemical markers of brain damage
    E G Zandbergen
    Department of Neurology and Clinical Neurophysiology, Academic Medical Centre/University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Intensive Care Med 27:1661-7. 2001
  6. ncbi Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia
    Stephen A Bernard
    Intensive Care Unit, Dandenong Hospital, Dandenong, Australia
    N Engl J Med 346:557-63. 2002
  7. pmc The spectrum of retinopathy in adults with Plasmodium falciparum malaria
    Richard J Maude
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 103:665-71. 2009
  8. pmc Brain swelling and mannitol therapy in adult cerebral malaria: a randomized trial
    Sanjib Mohanty
    Depatment of Medicine and Radiology, Ispat General Hospital, Rourkela, Orissa, India
    Clin Infect Dis 53:349-55. 2011
  9. doi Coma and consciousness: paradigms (re)framed by neuroimaging
    Steven Laureys
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, 4000 Liege, Belgium
    Neuroimage 61:478-91. 2012
  10. pmc Low CD4 count plus coma predicts cryptococcal meningitis in Tanzania
    Peter R Kisenge
    Department of Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
    BMC Infect Dis 7:39. 2007

Detail Information

Publications301 found, 100 shown here

  1. ncbi Predicting coma and other low responsive patients outcome using event-related brain potentials: a meta-analysis
    J Daltrozzo
    Department of Neurology, University Hospital of Strasbourg, France
    Clin Neurophysiol 118:606-14. 2007
  2. pmc Sequestration and microvascular congestion are associated with coma in human cerebral malaria
    Mark J Ponsford
    Nuffield Department of Clinical Laboratory Sciences, The John Radcliffe Hospital, University of Oxford, United Kingdom
    J Infect Dis 205:663-71. 2012
    The pathogenesis of coma in severe Plasmodium falciparum malaria remains poorly understood...
  3. ncbi Survival after treatment of rabies with induction of coma
    Rodney E Willoughby
    Department of Pediatric Infectious Diseases, Medical College of Wisconsin, Milwaukee, USA
    N Engl J Med 352:2508-14. 2005
    ..Treatment included induction of coma while a native immune response matured; rabies vaccine was not administered...
  4. ncbi Differentiating the pathologies of cerebral malaria by postmortem parasite counts
    Terrie E Taylor
    Department of Internal Medicine, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan 48824, USA
    Nat Med 10:143-5. 2004
    ..Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-..
  5. ncbi Systematic review of prediction of poor outcome in anoxic-ischaemic coma with biochemical markers of brain damage
    E G Zandbergen
    Department of Neurology and Clinical Neurophysiology, Academic Medical Centre/University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Intensive Care Med 27:1661-7. 2001
    ..can be derived from the combined results of studies concerning prediction of poor prognosis in anoxic-ischaemic coma with biochemical markers of brain damage in cerebrospinal fluid (CSF) or serum...
  6. ncbi Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia
    Stephen A Bernard
    Intensive Care Unit, Dandenong Hospital, Dandenong, Australia
    N Engl J Med 346:557-63. 2002
    ..In a randomized, controlled trial, we compared the effects of moderate hypothermia and normothermia in patients who remained unconscious after resuscitation from out-of-hospital cardiac arrest...
  7. pmc The spectrum of retinopathy in adults with Plasmodium falciparum malaria
    Richard J Maude
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 103:665-71. 2009
    ..obstruction were common in adults with severe falciparum malaria and correlated with disease severity and coma, suggesting that a compromised microcirculation has important pathophysiological significance in severe and ..
  8. pmc Brain swelling and mannitol therapy in adult cerebral malaria: a randomized trial
    Sanjib Mohanty
    Depatment of Medicine and Radiology, Ispat General Hospital, Rourkela, Orissa, India
    Clin Infect Dis 53:349-55. 2011
    b>Coma is a frequent presentation of severe malaria in adults and an important cause of death. The role of cerebral swelling in its pathogenesis, and the possible benefit of intravenous mannitol therapy to treat this, is uncertain.
  9. doi Coma and consciousness: paradigms (re)framed by neuroimaging
    Steven Laureys
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, 4000 Liege, Belgium
    Neuroimage 61:478-91. 2012
    ..We here review these advances in measurement and the scientific and broader implications of this rapidly progressing field of research...
  10. pmc Low CD4 count plus coma predicts cryptococcal meningitis in Tanzania
    Peter R Kisenge
    Department of Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania
    BMC Infect Dis 7:39. 2007
    ..Largely due to the lack of diagnostic reagents, the prevalence and clinical presentation of cryptococcal meningitis in Tanzania is poorly understood. This in turn is limiting the impact of increased fluconazole availability...
  11. ncbi The JFK Coma Recovery Scale--Revised
    Kathleen Kalmar
    JFK Johnson Rehabilitation Institute at JFK Medical Center, Brain Trauma Unit 3 ER Neuropsychology, 65 James Street, Edison, NJ 08818, USA
    Neuropsychol Rehabil 15:454-60. 2005
    The JFK Coma Recovery Scale (CRS) was developed to help characterise and monitor patients functioning at Rancho Levels I-IV and has been used widely in both clinical and research settings within the US and Europe...
  12. ncbi SSEPs and prognosis in postanoxic coma: only short or also long latency responses?
    E G J Zandbergen
    Department of Neurology and Clinical Neurophysiology, D2 112 Academic Medical Centre, University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Neurology 67:583-6. 2006
    Short latency somatosensory evoked potential (SSEP) (N20) is a good predictor of poor outcome in postanoxic coma. It has been suggested that the long latency response (N70) may increase the sensitivity of SSEPs for predicting poor outcome.
  13. doi Progression of auditory discrimination based on neural decoding predicts awakening from coma
    Athina Tzovara
    Electroencephalography Brain Mapping Core, Centre for Biomedical Imaging, Lausanne University Hospital and University of Lausanne, CH 1011 Lausanne, Switzerland
    Brain 136:81-9. 2013
    ..However, because auditory discrimination is assessed at various delays after coma onset, it is still unclear whether this impairment depends on the time of the recording...
  14. doi Therapeutic hypothermia is associated with improved neurologic outcome and survival in cardiac arrest survivors of non-shockable rhythms
    Justin B Lundbye
    Division of Cardiology, Hartford Hospital, Hartford, CT, United States
    Resuscitation 83:202-7. 2012
    ..We hypothesized that therapeutic hypothermia favorably impacts neurologic outcome and survival in patients resuscitated from cardiac arrest due to non-shockable rhythms...
  15. ncbi Coma scales for children with severe falciparum malaria
    C R Newton
    Kenya Medical Research Institute, Clinical Research Centre, Kilifi Unit, Kenya
    Trans R Soc Trop Med Hyg 91:161-5. 1997
    The Blantyre coma scale (BCS) is used to assess children with severe falciparum malaria, particularly as a criterion for cerebral malaria, but it has not been formally validated...
  16. ncbi Prediction of recovery from a post-traumatic coma state by diffusion-weighted imaging (DWI) in patients with diffuse axonal injury
    W B Zheng
    Department of Radiology, Second Hospital, Shantou University Medical College, Shantou, 515041, Guangdong, China
    Neuroradiology 49:271-9. 2007
    ..whether diffusion-weighted magnetic resonance (MR) imaging findings combined with initial clinical factors indicate the depth of shearing lesions in the brain structure and therefore relate to coma duration in diffuse axonal injury (DAI).
  17. ncbi Failure of therapeutic coma and ketamine for therapy of human rabies
    Thiravat Hemachudha
    Division of Neurology, Chulalongkorn University Hospital, Bangkok, Thailand
    J Neurovirol 12:407-9. 2006
    ..He received therapeutic coma with intravenous diazepam and sodium thiopental to maintain an electroencephalographic burst suppression pattern, ..
  18. pmc Frequency and timing of nonconvulsive status epilepticus in comatose post-cardiac arrest subjects treated with hypothermia
    Jon C Rittenberger
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurocrit Care 16:114-22. 2012
    ..However, nonconvulsive status epilepticus (NCSE) may cause persistent coma. The frequency and timing of NCSE after cardiac arrest is unknown.
  19. doi Prognosis of coma after therapeutic hypothermia: a prospective cohort study
    Aline Bouwes
    Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands
    Ann Neurol 71:206-12. 2012
  20. pmc Automated EEG entropy measurements in coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state
    Olivia Gosseries
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    Funct Neurol 26:25-30. 2011 investigate the usefulness of electroencephalography (EEG) entropy measurements in differentiating unconscious (coma or vegetative) from minimally conscious patients...
  21. ncbi Interobserver variation in the interpretation of SSEPs in anoxic-ischaemic coma
    E G J Zandbergen
    Department of Neurology and Clinical Neurophysiology, Academic Medical Centre University of Amsterdam, P O Box 22660, 1100 DD Amsterdam, and Department of Clinical Neurophysiology, Maastricht University Hospital, The Netherlands
    Clin Neurophysiol 117:1529-35. 2006
    To study interobserver variation in the interpretation of median nerve SSEPs in patients with anoxic-ischaemic coma.
  22. doi [Infant coma in the emergency department: 2 cases of MCAD deficiency]
    M Hoflack
    Service de Pediatrie, hôpital de l Archet II, 151 route de Saint Antoine de Ginestiere, Nice Cedex 3, France
    Arch Pediatr 17:1074-7. 2010
    ..We report the cases of 2 patients whose presentation was typical and severe. Early diagnosis of MCAD deficiency helped to start a simple treatment in both patients aimed at preventing further decompensation...
  23. pmc Electroencephalographic and clinical features of cerebral malaria
    J Crawley
    KEMRI Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Arch Dis Child 84:247-53. 2001
    ..We present the electroencephalographic (EEG) findings from a detailed clinical and electrophysiological study...
  24. pmc A clinical and EEG scoring system that predicts early cortical response (N20) to somatosensory evoked potentials and outcome after cardiac arrest
    Cedric Daubin
    Department of Medical Intensive Care, Caen University Hospital, Caen, France
    BMC Cardiovasc Disord 8:35. 2008
    Anoxic coma following cardiac arrest is a common problem with ethical, social, and legal consequences...
  25. doi The prevalence of seizures in comatose children in the pediatric intensive care unit: a prospective video-EEG study
    Amre Shahwan
    Children s Neuroscience Centre, The Royal Children s Hospital, Melbourne, Vic, Australia
    Epilepsia 51:1198-204. 2010
    ..We aimed to determine prospectively the prevalence of epileptic seizures (clinical and subclinical) in comatose children in the pediatric ICU using continuous video-EEG (v-EEG) monitoring...
  26. ncbi Detection of electrographic seizures with continuous EEG monitoring in critically ill patients
    J Claassen
    Division of Critical Care Neurology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032, USA
    Neurology 62:1743-8. 2004
    ..To identify patients most likely to have seizures documented on continuous EEG (cEEG) monitoring and patients who require more prolonged cEEG to record the first seizure...
  27. pmc Coma in fatal adult human malaria is not caused by cerebral oedema
    Isabelle M Medana
    Nuffield Department of Clinical Laboratory Sciences, The John Radcliffe Hospital, University of Oxford, Oxford, UK
    Malar J 10:267. 2011
    The role of brain oedema in the pathophysiology of cerebral malaria is controversial. Coma associated with severe Plasmodium falciparum malaria is multifactorial, but associated with histological evidence of parasitized erythrocyte ..
  28. ncbi Validation of a new coma scale: The FOUR score
    Eelco F M Wijdicks
    Division of Critical Care Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Neurol 58:585-93. 2005
    The Glasgow Coma Scale (GCS) has been widely adopted. Failure to assess the verbal score in intubated patients and the inability to test brainstem reflexes are shortcomings...
  29. doi Predictors of the need for rapid sequence intubation in the poisoned patient with reduced Glasgow coma score
    C Donald
    Emergency Department, Ninewells Hospital, Dundee DD1 9SY, UK
    Emerg Med J 26:510-2. 2009
    In patients presenting to the emergency department (ED) with significant poisoning and reduced Glasgow coma score (GCS), the decision to proceed with rapid sequence intubation can be a difficult one...
  30. doi Prognostic value of standard EEG in traumatic and non-traumatic disorders of consciousness following coma
    S Bagnato
    Neurorehabilitation Unit, Rehabilitation Department, Fondazione Istituto San Raffaele G Giglio, Cefalù PA, Italy
    Clin Neurophysiol 121:274-80. 2010
    ..the prognostic value of standard electroencephalogram (EEG) in predicting the improvement of the level of consciousness in patients suffering from severe disturbances of consciousness following coma caused by acute brain injuries.
  31. ncbi Glasgow Coma Scale in acute poisonings before and after use of antidote in patients with history of use of psychotropic agents
    Tonka Poplas-Susić
    Department of Family Medicine, Ljubljana, Slovenia
    Srp Arh Celok Lek 138:210-3. 2010
    ..Data on emergency interventions in poisonings are scarce. Objective To determine the effectiveness of antidote therapy in acute poisoning-related emergency medical services (EMS) interventions...
  32. ncbi Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma
    Menno D de Jong
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 352:686-91. 2005
    In southern Vietnam, a four-year-old boy presented with severe diarrhea, followed by seizures, coma, and death. The cerebrospinal fluid contained 1 white cell per cubic millimeter, normal glucose levels, and increased levels of protein (0...
  33. ncbi Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial
    Pratik P Pandharipande
    Department of Anesthesiology Division of Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 298:2644-53. 2007
    ..ICU) patients, but this and other benzodiazepine drugs may contribute to acute brain dysfunction, ie, delirium and coma, associated with prolonged hospital stays, costs, and increased mortality...
  34. ncbi Prediction of short-term and long-term outcomes after cardiac arrest: a prospective multivariate approach combining biochemical, clinical, electrophysiological, and neuropsychological investigations
    Jörn Prohl
    Department of Biological Psychology and Neuropsychology, University of Hamburg, Germany
    Crit Care Med 35:1230-7. 2007
    ..To determine the prognostic accuracy of biochemical, clinical, electrophysiological, and neuropsychological investigations in predicting outcomes after cardiac arrest...
  35. ncbi Improved outcome prediction in unconscious cardiac arrest survivors with sensory evoked potentials compared with clinical assessment
    C Madl
    Department of Internal Medicine IV, University of Vienna, Austria
    Crit Care Med 28:721-6. 2000
    ..To compare the prognostic ability of sensory evoked potentials in cardiac arrest survivors with the outcome predicted by a panel of experienced emergency physicians based on detailed prehospital, clinical, and laboratory data...
  36. pmc The eye in cerebral malaria: what can it teach us?
    Richard J Maude
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 103:661-4. 2009
    The pathophysiology of coma in cerebral malaria (CM) is not well understood...
  37. doi Coma
    G Bryan Young
    Department of Neurology and Critical Care Medicine, The University of Western Ontario, London, Ontario, Canada
    Ann N Y Acad Sci 1157:32-47. 2009
    b>Coma is a state of unarousable unconsciousness due to dysfunction of the brain's ascending reticular activating system (ARAS), which is responsible for arousal and the maintenance of wakefulness...
  38. pmc Coma associated with microscopy-diagnosed Plasmodium vivax: a prospective study in Papua, Indonesia
    Daniel A Lampah
    National Institute of Health Research, Development Menzies School of Health Research Research Program, District Ministry of Health, Timika, Papua, Indonesia
    PLoS Negl Trop Dis 5:e1032. 2011
    b>Coma complicates Plasmodium falciparum infection but is uncommonly associated with P. vivax. Most series of vivax coma have been retrospective and have not utilized molecular methods to exclude mixed infections with P. falciparum.
  39. doi Magnetic resonance spectroscopy and diffusion tensor imaging in coma survivors: promises and pitfalls
    Luaba Tshibanda
    Coma Science Group, Cyclotron Research Center and Neurology Department, University and University Hospital of Liège, Belgium
    Prog Brain Res 177:215-29. 2009
    ..The role of neuroimaging in coma survivors has increased beyond the simple evaluation of morphological abnormalities...
  40. doi Predictors of poor neurologic outcome after induced mild hypothermia following cardiac arrest
    E Al Thenayan
    Department of Clinical Neurological Sciences, London Health Sciences Centre University Hospital, London, Ontario, Canada
    Neurology 71:1535-7. 2008
    ..However, these studies preceded the advent of therapeutic induced mild hypothermia (TIMH), which may alter their validity. The objective of this study is to reassess the validity of these predictors in post-CA patients treated with TIMH...
  41. ncbi Prediction of 'awakening' and outcome in prolonged acute coma from severe traumatic brain injury: evidence for validity of short latency SEPs
    Aldo Amantini
    Department of Neurological and Psychiatric Sciences, University of Florence, Az Ospedaliera Careggi, V le Morgagni 85, Firenze 50134, Italy
    Clin Neurophysiol 116:229-35. 2005
    ..To evaluate the prognostic value of somatosensory evoked potentials (SEPs) in severe traumatic brain injury (TBI) considering both 'awakening' and disability...
  42. ncbi Response to selection for rapid chill-coma recovery in Drosophila melanogaster: physiology and life-history traits
    Alisha R Anderson
    Centre for Environmental Stress and Adaptation Research, School of Biological Sciences, Monash University, Victoria 3800, Australia
    Genet Res 85:15-22. 2005
    ..resistance that varies geographically in Drosophila melanogaster and that is amenable to genetic analysis is chill-coma recovery. Three replicate lines of D...
  43. ncbi The utility of median somatosensory evoked potentials in anoxic-ischemic coma
    Ted L Rothstein
    Department of Neurology, Rm 7 402, George Washington University, 2150 Pennsylvania Avenue, NW, Washington, DC 20037, USA
    Rev Neurosci 20:221-33. 2009
    ..somatosensory evoked potentials (SSEP) supplement and enhance neurological examination findings in anoxic-ischemic coma and are useful as an early guide in predicting outcome...
  44. pmc The effectiveness of selected Tai Chi exercises in a program of strategic rehabilitation aimed at improving the self-care skills of patients aroused from prolonged coma after severe TBI
    Grzegorz Manko
    Department of Ergonomics and Exertion Physiology, Institute of Physiotherapy, Faculty of Allied Health Sciences, College of Medicine, Jagiellonian University, Cracow, Poland
    Med Sci Monit 19:767-72. 2013
    Difficulties in self-care constitute a very common problem for patients recovering from prolonged coma after a severe TBI, and a major factor reducing their quality of life...
  45. ncbi A measure of neurobehavioral functioning after coma. Part II: Clinical and scientific implementation
    Theresa Louise Bender Pape
    Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research and Development Service, Edward Hines Jr VA Hospital, PO Box 5000 M C 151H, Hines, IL 60141, USA
    J Rehabil Res Dev 42:19-27. 2005
    ..Two investigations of treatment effectiveness during coma recovery and examination of the relationship between behavioral changes and neural adaptation are also described...
  46. pmc Tacrolimus induced leukoencephalopathy presenting with status epilepticus and prolonged coma
    Mithri R Junna
    J Neurol Neurosurg Psychiatry 78:1410-1. 2007
  47. pmc Observations on comatose survivors of cardiopulmonary resuscitation with generalized myoclonus
    Frank Thömke
    Department of Neurology, Johannes Gutenberg Universitat, Langenbeckstrasse 1, D 55101 Mainz, Germany
    BMC Neurol 5:14. 2005
    ..There is also a paucity of data on the temporal dynamics of electroenephalographic (EEG) abnormalities in these patients...
  48. ncbi Central neurocytoma presenting with massive hemorrhage leading to coma--case report
    Yuzo Terakawa
    Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka
    Neurol Med Chir (Tokyo) 50:139-43. 2010
    ..Surgical intervention should thoroughly be considered, if intratumoral hemorrhage is present, as hemorrhage from the central neurocytoma may lead to serious neurological complications...
  49. doi Electrophysiological investigations of brain function in coma, vegetative and minimally conscious patients
    R Lehembre
    Coma Science Group, Cyclotron Research Centre and Neurolgy Department, University of Liege, Belgium
    Arch Ital Biol 150:122-39. 2012
    ..This will allow the identification of specific patterns related to the diagnostic of consciousness. Standardized procedures in the use of BCIs will also be needed to find the most suited technique for each individual patient...
  50. pmc Longitudinal changes in global brain volume between 79 and 409 days after traumatic brain injury: relationship with duration of coma
    Mehul A Trivedi
    William S Middleton Memorial VA Hospital, Geriatric Research Education and Clinical Center GRECC, Madison, Wisconsin 53705, USA
    J Neurotrauma 24:766-71. 2007
    ..1%, n = 30). Greater %BVC was associated with longer duration of post-injury coma. These results confirm previous findings from cross-sectional studies and argue that the brain undergoes continued ..
  51. ncbi Rhabdomyolysis and coma associated with amisulpride: a probable atypical presentation of neuroleptic malignant syndrome
    E Cem Atbasoglu
    J Clin Psychiatry 65:1724-5. 2004
  52. pmc Continuous EEG monitoring in Kenyan children with non-traumatic coma
    Samson Gwer
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
    Arch Dis Child 97:343-9. 2012
    The aim of this study was to describe the EEG and clinical profile of seizures in children with non-traumatic coma, compare seizure detection by clinical observations with that by continuous EEG, and relate EEG features to outcome.
  53. doi The relationship between age and the manifestations of and mortality associated with severe malaria
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 47:151-7. 2008
    ..The reported case-fatality rate associated with severe malaria varies widely. Whether age is an independent risk factor is uncertain...
  54. ncbi Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit
    E Wesley Ely
    Department of Medicine, Division of General Internal Medicine and Center for Health Services Research and the Veterans Affairs Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, Tenn, USA
    JAMA 291:1753-62. 2004
    ..In the intensive care unit (ICU), delirium is a common yet underdiagnosed form of organ dysfunction, and its contribution to patient outcomes is unclear...
  55. pmc Seizure and coma following Kratom (Mitragynina speciosa Korth) exposure
    Jamie L Nelsen
    Department of Emergency Medicine, SUNY Upstate Medical University, Upstate New York Poison Center, 250 Harrison Street, Syracuse, NY 13210, USA
    J Med Toxicol 6:424-6. 2010
    ..We report a rare case of Kratom toxicity characterized by a seizure and coma confirmed by urinary analysis of mitragynine by high performance liquid chromatography coupled to electrospray ..
  56. pmc Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice
    Katharina Eikermann-Haerter
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 31:5755-63. 2011
    ..S218L mutation causes severe channel dysfunction, and paroxysmal migraine attacks can be accompanied by seizures, coma, and hemiplegia; patients expressing the R192Q mutation exhibit hemiplegia only...
  57. doi SUDEP, suspected positional airway obstruction, and hypoventilation in postictal coma
    James X Tao
    Department of Neurology, Adult Epilepsy Center, The University of Chicago, Chicago, IL 60637, USA
    Epilepsia 51:2344-7. 2010
    ..The cause of her death was likely asphyxia from the convergence of postictal coma and suspected positional airway obstruction and hypoventilation, rather than the commonly suspected periictal ..
  58. doi Cold hardening modulates K+ homeostasis in the brain of Drosophila melanogaster during chill coma
    Gary A B Armstrong
    Department of Biology, Queen s University, Kingston, ON, Canada K7L 3N6
    J Insect Physiol 58:1511-6. 2012
    ..At both low and high temperature extremes insects enter a coma during which individuals do not display behaviour and are unresponsive to stimulation...
  59. ncbi Truncation of the krebs cycle during hypoglycemic coma
    Garnette R Sutherland
    Seaman Family MR Research Centre, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Med Chem 4:379-85. 2008
    There is a misconception that hypoglycemic nerve cell death occurs easily, and can happen in the absence of coma. In fact, coma is the prerequisite for neuronal death, which occurs via metabolic excitatory amino acid release...
  60. ncbi Does modification of the Innsbruck and the Glasgow Coma Scales improve their ability to predict functional outcome?
    M N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Arch Neurol 54:606-11. 1997
    ..The accurate prediction of functional outcome requires the development of multivariate models. To enhance their contribution to such models, the predictive power of each component must be optimized...
  61. ncbi Successful use of the new high-dose mannitol treatment in patients with Glasgow Coma Scale scores of 3 and bilateral abnormal pupillary widening: a randomized trial
    Julio Cruz
    The Comprehensive International Center for Neuroemergencies and Federal University of São Paulo, SP, Brazil
    J Neurosurg 100:376-83. 2004
  62. ncbi Hypoglycemic coma in a diabetic patient on peritoneal dialysis due to interference of icodextrin metabolites with capillary blood glucose measurements
    Emmanuel Disse
    Diabetes Care 27:2279. 2004
  63. ncbi [Coma caused by hypermagnesemia in a pregnant woman complicated with HELLP syndrome]
    Kentaro Hayashi
    Department of Anesthesiology, University of the Ryukyus Faculty of Medicine, Okinawa 903 0215
    Masui 52:783-5. 2003 describes a pregnant woman with acute renal failure, caused by aggravation of HELLP syndrome, who developed coma induced by overdose of continuous magnesium sulfate administration for eclampsia...
  64. ncbi Adult presentation of MCAD deficiency revealed by coma and severe arrythmias
    F Feillet
    Service de Réanimation Médicale Pédiatrique, Hôpital d Enfants, CHU Brabois, Allee du Morvan, Vandoeuvre les Nancy, 54500 Nancy, France
    Intensive Care Med 29:1594-7. 2003
    ..he became drowsy and agitated, developed ventricular tachycardia and his neurological state worsened (Glasgow coma score 6)...
  65. pmc Fosphenytoin for seizure prevention in childhood coma in Africa: a randomized clinical trial
    Samson A Gwer
    Department of Medical Physiology, School of Health Sciences, Kenyatta University, Nairobi, Kenya Clinical Research, Afya Research Africa, Nairobi, Kenya Electronic address
    J Crit Care 28:1086-92. 2013
    We conducted a double-blind trial to determine whether a single intramuscular injection of fosphenytoin prevents seizures and neurologic sequelae in children with acute coma.
  66. ncbi Electrical treatment of reduced consciousness: experience with coma and Alzheimer's disease
    E B Cooper
    Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
    Neuropsychol Rehabil 15:389-405. 2005
    ..There is 11 years of experience in the USA of using nerve stimulation for acute coma after traumatic brain injury...
  67. ncbi Rationality of administered gentamicin dose in cerebral coma patients treated in an intensive care unit
    Tomas Janusonis
    Department of Theoretical and Clinical Pharmacology, Medical Academy, Lithuanian University of Health Sciences, A Mickeviciaus, Kaunas, Lithuania
    Medicina (Kaunas) 47:79-84. 2011
    ..The aim of this study was to determine Cmax and Cmin in serum of cerebral coma ICU patients when a dosage of gentamicin of 5 mg/kg body weight was administered once daily; to evaluate the ..
  68. ncbi Pain-related middle-latency somatosensory evoked potentials in the prognosis of post anoxic coma: a preliminary report
    P Zanatta
    Department of Anesthesia and Intensive Care, Neurophysiology, Treviso Regional Hospital, Piazzale Ospedale 1, Treviso, Italy
    Minerva Anestesiol 78:749-56. 2012
    ..The main aim of the present study was to investigate whether painful electrical stimulation might be considered a provocative test in producing MLCEPs and predictor of patient's outcomes after cardiac arrest...
  69. pmc Predictive value of neurological examination for early cortical responses to somatosensory evoked potentials in patients with postanoxic coma
    Aline Bouwes
    Department of Intensive Care, Room C3 423, Academic Medical Centre, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    J Neurol 259:537-41. 2012
    ..responses of median nerve somatosensory evoked potentials (SEP) predicts poor neurological outcome in postanoxic coma after cardiopulmonary resuscitation (CPR)...
  70. ncbi MR imaging in comatose survivors of cardiac resuscitation
    E F Wijdicks
    Department of Neurology, Mayo Medical Center and Mayo Foundation, Rochester, Minnesota 55905, USA
    AJNR Am J Neuroradiol 22:1561-5. 2001
    ..If confirmed, MR imaging may have a role as a prognosticating test in anoxic-ischemic coma.
  71. doi Repetitive transcranial magnetic stimulation-associated neurobehavioral gains during coma recovery
    Theresa Louise-Bender Pape
    The Department of Veterans Affairs, Edward Hines Jr VA Hospital, Hines, Illinois 60141, USA
    Brain Stimul 2:22-35. 2009
    ..This report presents findings from the first participant of a safety and efficacy study that examined a therapeutic rTMS protocol for persons with severe traumatic brain injury (TBI)...
  72. doi The focus of family members' functioning in the acute phase of traumatic coma: part two: Protecting from suffering and protecting what remains to rebuild life
    Sofie T L Verhaeghe
    Ghent University, De Pintelaan, Ghent, Belgium
    J Clin Nurs 19:583-9. 2010
    The identification and description of the basic psychological process linked with the focus of family members' functioning during the acute phase of traumatic coma.
  73. doi Brain dysfunction in patients with chronic critical illness
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Respir Care 57:947-55; discussion 955-7. 2012
    Critically ill patients frequently experience acute brain dysfunction in the form of coma or delirium, both of which are common during acute and chronic critical illness (CCI)...
  74. ncbi Urinary tract infection and coma
    Bernard De Jonghe
    Service de Reanimation Medicale, Centre Hospitalier de Poissy Saint Germain, 78300, Poissy, France
    Lancet 360:996. 2002
  75. pmc The effects of hypoglycemic and alcoholic coma on the blood-brain barrier permeability
    Hatice Yorulmaz
    Department of Physiotherapy and Rehabilitation, Halic University, Health Sciences, Istanbul, Turkey
    Bosn J Basic Med Sci 11:108-12. 2011
    In this investigation, the effects of hypoglycemic coma and alcoholic coma on the blood-brain barrier (BBB) permeability have been compared...
  76. doi [Deep non-reactive reversible coma after a Mediterranean neurotoxic fish poisoning]
    A Awada
    Service de Neurologie, Hotel Dieu de France, Achrafieh, Beyrouth, Liban
    Rev Neurol (Paris) 166:337-40. 2010
    Neurotoxic fish poisoning appears to be a recent phenomenon in the Mediterranean Sea. We report a case of deep non-reactive reversible coma after ingestion of Mediterranean fish innards.
  77. ncbi Lipid emulsion improves Glasgow coma scale and decreases blood glucose level in the setting of acute non-local anesthetic drug poisoning--a randomized controlled trial
    F Taftachi
    Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Hazrat Rasoul Akram Hospital, Tehran, Iran
    Eur Rev Med Pharmacol Sci 16:38-42. 2012
    ..To date, no study has been performed to evaluate the antidotal effect of intravenous lipid emulsion on the poisoned patients' level of consciousness and routine metabolic profile tests in non-local anesthetic drug overdose...
  78. ncbi The Glasgow Coma Scale--a brief review. Past, present, future
    Georgios Matis
    Neurosurgery Department, Democritus University of Thrace, University General Hospital of Alexandroupolis, Greece
    Acta Neurol Belg 108:75-89. 2008
    The Glasgow Coma Scale (GCS) was introduced in 1974 aiming at standardizing assessment of level of consciousness in head injured patients...
  79. ncbi Acupuncture treatment for 15 cases of post-traumatic coma
    Jing He
    Huaxi Hospital, Sichuan University, Chengdu, Sichuan 610041, China
    J Tradit Chin Med 25:171-3. 2005
    In order to observe the effects of acupuncture combined with point-injection therapy on post-traumatic coma, 30 such cases were randomly divided into the following two groups...
  80. ncbi Rapid coma resolution with artemether in Malawian children with cerebral malaria
    T E Taylor
    Queen Elizabeth Central Hospital, Blantyre, Malawi
    Lancet 341:661-2. 1993
    ..0002). Coma resolution times were also shorter with artemether than with quinine (8 [4-15] vs 14 [10-36] h, p = 0.01).
  81. ncbi [Strategies diagnosis of polytraumatized adult patients with coma]
    M Leone
    Département d anesthésie réanimation et centre de traumatologie, CHU Nord, Bd P Dramard, 13915 Marseille, France
    Ann Fr Anesth Reanim 21:50-66. 2002
    ..To review the diagnostic strategy of management of multiple trauma patient during the first hours...
  82. doi Prognosis of coma after cardiac arrest in the era of hypothermia
    Michael De Georgia
    Case Western Reserve University, Cleveland, OH, USA
    Continuum (Minneap Minn) 18:515-31. 2012
    ..Outcome prediction is more difficult in comatose survivors of cardiac arrest who are treated with hypothermia than in those who are kept normothermic. This article compares prognostication measures in these two groups of patients...
  83. doi Oxycodone overdose causes naloxone responsive coma and QT prolongation
    I Berling
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah, NSW, Australia
    QJM 106:35-41. 2013
    ..Given the high prescription rate and increasing use of oxycodone, an understanding of its effects and treatment in overdose is necessary...
  84. ncbi Routine intracranial pressure monitoring in acute coma
    Rob J Forsyth
    Institute of Neuroscience, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne, Tyne and Wear, UK, NE1 4LP
    Cochrane Database Syst Rev 2:CD002043. 2010
    ..OBJECTIVES: To determine whether routine ICP monitoring in all acute cases of severe coma reduces the risk of all-cause mortality or severe disability at final follow-up...
  85. doi Impact of prolonged periodic epileptiform discharges on coma prognosis
    Charlene Ong
    Department of Neurology, University of Washington in St Louis, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Neurocrit Care 17:39-44. 2012
    ..We hypothesized that frequent PED activity in comatose patients is associated with reduced likelihood of recovery of consciousness...
  86. doi Emotional electrodermal response in coma and other low-responsive patients
    Jérôme Daltrozzo
    CNRS UPS 858, Louis Pasteur University, Strasbourg, France
    Neurosci Lett 475:44-7. 2010
    Emotional processing in coma remains an open question. Skin conductance responses to emotional and neutral auditory stimuli were recorded in 13 low-responsive patients (12 of whom were in coma)...
  87. doi Coma caused by isoniazid poisoning in a patient treated with pyridoxine and hemodialysis
    Wei Ping Tai
    Department of Gastroenterology, Guangdong No 2 Provincial People s Hospital, Guangzhou, China
    Adv Ther 25:1085-8. 2008
    ..with a high prevalence rate of tuberculosis, acute ingestion of isoniazid has been reported as a potential cause of coma. In this study, we present the diagnosis and treatment of isoniazid poisoning in a case with acute coma as the ..
  88. doi Avermectin intoxication with coma, myoclonus, and polyneuropathy
    Yueh Feng Sung
    Department of Neurology, Tri Service General Hospital, Taipei, Taiwan, Republic of China
    Clin Toxicol (Phila) 47:686-8. 2009
    ..Avermectin has been used in the control of parasites and insects. Severe poisoning symptoms in humans include altered mental status, hypotension, and respiratory failure...
  89. ncbi Gabapentin-induced coma in a patient with renal failure
    Ayhan Dogukan
    Divison of Nephrology, Firat University, Elazig, Turkey
    Hemodial Int 10:168-9. 2006
    ..The patient was improved by hemodialysis. Gabapentin toxicity should be considered when mental status changes develop in patients with renal failure after even a single dose...
  90. ncbi [Hypoglycemic coma revealing a solitary fibrous tumor of the pleura]
    M Kafih
    Service des urgences de chirurgie viscérale, CHU Ibn Rochd, Casablanca
    Presse Med 34:1370. 2005
    ..Solitary fibrous tumor of the pleura (TFSP) is rare. When associated with hypoglycemia it is commonly referred to as Doege-Potter syndrome...
  91. ncbi The EEG in metabolic encephalopathy and coma
    Peter W Kaplan
    Department of Neurology, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, U S A
    J Clin Neurophysiol 21:307-18. 2004
    Excellent early work on stupor and coma can be found (particularly with regard to anoxia) in the work of Fischgold and Mathis (1959) in France, and Pamela Prior in England (1973a)...
  92. ncbi Coagulation, coma, and outcome in bacterial meningitis--an observational study of 38 adult cases
    Maciej Michał Kowalik
    Department of Anaesthesiology and Intensive Therapy, Medical University of Gdansk, ul Debinki 7, 80 211 Gdansk, Poland
    J Infect 55:141-8. 2007
    ..The purpose of this study was to evaluate the epidemiology of intravascular coagulation in bacterial meningitis and to recognise the associations with disease severity and outcome...
  93. pmc Human rabies encephalitis following bat exposure: failure of therapeutic coma
    Robert C McDermid
    Division of Critical Care Medicine, University of Alberta, Edmonton, Alta
    CMAJ 178:557-61. 2008
  94. doi Paediatric coma scales
    Fenella J Kirkham
    Neurosciences Unit, Institute of Child Health, University College London, London, UK
    Dev Med Child Neurol 50:267-74. 2008
    Traumatic and non-traumatic coma is a common problem in paediatric practice with high mortality and morbidity...
  95. ncbi Extensive white matter injury in hypoglycemic coma
    Ji Hyun Kim
    Department of Neurology, Guro Hospital, Korea University School of Medicine, 80 Guro dong, Guro Ku, Seoul, 152 703, Republic of Korea
    Neurology 68:1074. 2007
  96. doi Nonconvulsive status epilepticus and coma
    Gerhard Bauer
    Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
    Epilepsia 51:177-90. 2010
    ..In many advanced coma stages, the EEG exhibits continuous or periodic EEG abnormalities, but their causal role in coma remains unclear in ..
  97. doi Combining coma score and serum biomarker levels to predict unfavorable outcome following childhood brain trauma
    Tsz Yan M Lo
    Child Life and Health, University of Edinburgh, Edinburgh, United Kingdom
    J Neurotrauma 27:2139-45. 2010
    This study aims to determine if pairing the Glasgow Coma Scale (GCS) with serum biomarker levels may achieve higher outcome predictive values than using either the GCS or biomarker levels alone in childhood brain trauma...
  98. ncbi Mechanism of respiratory insufficiency in pure or mixed drug-induced coma involving benzodiazepines
    Papa N Gueye
    Réanimation Médicale et Toxicologique, Hopital Lariboisiere, Paris, France
    J Toxicol Clin Toxicol 40:35-47. 2002
    We tested the hypothesis that the mechanism of respiratory insufficiency in drug-induced coma involving benzodiazepines is an increase in upper airway resistance.
  99. ncbi Brain O2 consumption and glutamate release during hypoglycemic coma in piglets are temperature sensitive
    R N Ichord
    Departments of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Am J Physiol 276:H2053-62. 1999
    ..We tested the hypothesis that increased CMRO2 during hypoglycemic coma is temperature dependent and coincides with increased excitatory amino acids (EAA)...
  100. doi Arousal effects of orexin A on acute alcohol intoxication-induced coma in rats
    Xiaojun Jia
    Department of Physiology, Third Military Medical University, Chongqing 400038, PR China
    Neuropharmacology 62:775-83. 2012 normal mammalian animals, but whether orexins exert arousal effects under pathological condition such as coma was little studied...
  101. pmc Propofol in myoclonus status epilepticus in comatose patients following cardiac resuscitation
    E F M Wijdicks
    J Neurol Neurosurg Psychiatry 73:94-5. 2002

Research Grants62

  1. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  2. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    ..Although termed "mild" in comparison to brain injuries resulting in death, coma, or paralysis, mTBI, particularly repetitive mTBI characteristic of soldiers deployed to Operation Iraqi Freedom (..
  3. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..seizures, and Reyes syndrome, which is characterized by liver dysfunction, hypoketotic hypoglycemia, and coma. In patients with CPT1A deficiency symptoms are triggered by fasting, as a result of the requirement for fatty acid ..
  4. Emergency Neurophysiological Assessment Bedside Logic Engine
    Don M Tucker; Fiscal Year: 2010
    ..g,. seizure, burst-suppression coma, drug toxicity, vasospasm, focal slowing due to hematoma)...
    Anthony Carruthers; Fiscal Year: 2012
    ..Impaired barrier transport compromises tissue function causing apoptosis, seizures, focal neurologic deficits and coma and may have genetic, endocrine and pharmacologic origins. Long-term glycopenia disrupts development...
  6. Decompressive craniotomy versus medical therapy for refractory intracranial hyper
    Raminder Nirula; Fiscal Year: 2010
    ..between cerebral oxygen delivery and consumption, such as osmotic diuresis, hyperosmolar therapies, barbiturate coma and hypothermia have had varying success...
  7. Adipose Organ Transplant for Treatment of Maple Syrup Urine Disease
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2012 plasma and tissues, leading to progressive neurological damage, cognitive decline, vomiting, seizures, coma, and death. Standard treatment involves intensive nutritional support to lower BCAA intake...
  8. Basal Forebrain Cellular Mechanisms of Cortical Activation
    Robert W McCarley; Fiscal Year: 2013
    ..Furthermore, gamma deficits are a prominent feature of sleep disorders, coma, and Alzheimer's disease, other conditions prevalent in veterans and military personnel...
  9. Intracellular Targeting of Proinflammatory Pathways to Ameliorate Type 1 Diabetes
    Daniel J Moore; Fiscal Year: 2010
    ..can provide a relatively normal life for the affected children and adults, the therapy poses risk for seizures, coma, and death and even compliant patients are not always protected from complications such as blindness, renal failure,..
  10. The role of Histidine rich protein II in cerebral malaria
    Priya Pal; Fiscal Year: 2013
    ..Cerebral malaria (CM) is the most severe manifestation of malaria and results in decreased sensorium, coma, death, and in survivors lasting neurological complications...
  11. The MIND USA Study
    E Wesley Ely; Fiscal Year: 2012
    ..haloperidol or ziprasidone will increase days alive without acute brain dysfunction (referred to as delirium/coma-free days or DCFDs) over a 14-day period compared with placebo and compared to one another...
  12. Mechanism for Reduced Adrenomedullary Epinephrine Release in Type 1 Diabetes
    BRANLY OSVALDO ORBAN; Fiscal Year: 2012 T1DM, making diabetic patients particularly prone to asymptomatic hypoglycemia that, if untreated, can lead to coma and death...
  13. Effectiveness of ICP Monitoring in Pediatric Traumatic Brain Injury
    TELLEN BENNETT; Fiscal Year: 2013
    ..The available evidence to support acute interventions in children with severe TBI (Glasgow Coma Scale d 8) is limited...
  14. Altering Sedation Paradigms to Improve Brain Injury and Survival in Severe Sepsis
    Pratik Pandharipande; Fiscal Year: 2013
    ..This acute brain dysfunction, manifested as delirium and coma, occurs in 50%-70% of MV septic patients and is a significant contributor not only to death but also to functional ..
  15. Chemokines in Zambian children with Cerebral Malaria
    Monique F Stins; Fiscal Year: 2013
    ..Neurological symptoms and signs include impaired consciousness, coma, delirium, seizures, and increased intracranial hypertension...
  16. The Functional Significance of Conformational States in Glutamatergic Signaling
    ..g. drowsiness, hallucinations, and coma)...
  17. Analysis of novel in vivo derived Plasmodium falciparum transcriptional profiles
    JOHANNA PATRICIA DAILY; Fiscal Year: 2012
    ..leads to widely different clinical conditions in children [unreadable]ranging from mild flu-like symptoms to coma and death...
  18. Towards the neuronal correlates of visual awareness
    Gabriel Kreiman; Fiscal Year: 2009
    ..conscious processing can be devastating and are at the core of seemingly diverse conditions as epilepsy, vegetative coma, schizophrenia and autism...
  19. Structural Biology of Multifunctional Bacterial Phosphatases
    Matthew B Neiditch; Fiscal Year: 2012
    ..Another subset of Rap proteins downregulates the development of genetic competence in B. subtilis by inhibiting ComA, the master transcriptional regulator of early competence gene expression, from binding to target DNA promoters...
    James J Pekar; Fiscal Year: 2011
    ..The ultimate example of this may be the coma patients of Dr. Christensen...
  21. Domoic Acid Neurotoxicity in Native Americans
    Lynn M Grattan; Fiscal Year: 2013
    ..Persons who ate mussels with high levels of DA suffered serious medical illnesses, including seizures and coma, and 3 people died. Survivors were left with a profound memory disorder, Amnesic Shellfish poisoning (ASP)...
  22. Microparticles, a new player in cerebral malaria pathogenesis
    VALERY MADELEINE COMBES; Fiscal Year: 2013
    ..reported a marked increase in MPs in patients with CM, and that the numbers of platelet MPs correlated with coma depth and thrombocytopenia...
  23. Comparative Efficacy of Phenylbutyrate vs. Benzoate in Urea Cycle Disorders
    Juan Marini; Fiscal Year: 2013
    ..Disorders (UCD) patients results in hyperammonemia that causes irritability, lethargy, cerebral edema, seizures and coma that can lead to death...
  24. Pancreatic endocrine network control of glucagon counterregulation
    Anthony L McCall; Fiscal Year: 2013
    ..Hypoglycemia can cause coma, seizures, accidents or even death...
  25. Nitric Oxide and Malaria
    JOE BRICE WEINBERG; Fiscal Year: 2012
    ..In severe malaria patients, we will also measure lactate clearance, coma recovery time, and survival...
  26. Macrostructural and Microstructural Imaging Biomarkers of Traumatic Brain Injury
    Pratik Mukherjee; Fiscal Year: 2012
    ..outcomes at one year after injury, after controlling for clinical measures of injury severity including Glasgow Coma Scale, duration of unconsciousness, and duration of post-traumatic amnesia...
  27. Consequences of Cardiac Arrest: Brain Injury
    NITISH VYOMESH THAKOR; Fiscal Year: 2013
    ..1: We will discover the clinically relevant and neurophysiologically validated electrical markers of arousal from coma after CA...
  28. Predicting Acute Brain Dysfunction in Older Patients: A Quality Improvement Tool
    Eduard E Vasilevskis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute brain dysfunction in the form of delirium or coma affects 50% of critically ill patients and is extremely hazardous...
  29. Music, Science &Medicine: Frontiers in Biomedical Research &Clinical Applicatio
    PAULA ANNE TALLAL; Fiscal Year: 2011
    ..presentations on the physiology or music treatment of dementia, autism, language acquisition problems, pain, or coma. Submitted abstracts addressing additional science research and clinical music work (through videos and posters) ..
  30. Dynamic Neuroimaging with High-resolution SSVEPs
    Ramesh Srinivasan; Fiscal Year: 2012
    ..and neurological conditions (epilepsies, head trauma, strokes, coma, Alzheimer's disease, etc.)...
  31. Redesigning General Anesthesia
    Matthew A Wilson; Fiscal Year: 2013 creating general anesthesia;reduction in morbidity;improved brain function monitoring;safer anesthesia care by non-anesthesiologists;and possibly novel therapies for arousal disorders such as depression, insomnia, pain and coma.
  32. Role of the midline thalamus in arousal, attention and cognition
    ROBERT PAUL VERTES; Fiscal Year: 2013
    ..In this regard, it is well recognized that destruction of the midline thalamus in humans produces coma;and its partial disruption gives rise to a condition termed the minimally conscious state (MCS) -- or one in which ..
  33. Planning a Multicenter Cooling Trial for Hyperammonemic Metabolic Crises
    DAVID LLOYD WESSEL; Fiscal Year: 2013
    ..In the 1980s the mortality of neonates that presented with HA and in coma due to complete blocks in the urea cycle approached 50%, despite aggressive treatment with hemodialysis...
    PETER KARL SORGER; Fiscal Year: 2010
    ..Aim 2. The role of the inner kinetochore in organizing and assembling a "linker" layer comprising the NdcSO, COMA, MIND and Spc105 complexes will be studied in vitro and in vivo Aim 3...
  35. Biochemical Markers of Traumatic Brain Injury
    STEVEN ANDREW ROBICSEK; Fiscal Year: 2010
    ..g. Glasgow Coma Scale-GCS), injury type (e.g. diffuse injury vs. mass lesion), occurrence of secondary insults (e.g...
  36. Biomarkers of Injury and Outcome in Pro-TECT III (BIO-ProTECT)
    MICHAEL ROSS FRANKEL; Fiscal Year: 2013
    ..levels of S100B, GFAP, UCH-L1 and SBDP150 are more accurate predictors of the extent of injury than the Glasgow Coma Scale and computed tomography...
  37. Urea Cycle Disorders Satellite Symposium to the 12th ICIEM
    Marshall L Summar; Fiscal Year: 2013
    ..The toxic ammonia can accumulate causing coma and brain damage. UCDs are associated with high morbidity and mortality rates...
    HARRY MOBLEY; Fiscal Year: 1990
    ..the gram-negative bacilli isolated produced the enzyme urease which has been implicated in pyelonephritis, hepatic coma, hyperammonemia, complement inactivation, and kidney and bladder stone formation...
  39. Genotype Analysis for Diagnosis of Urea Cycle Disorders
    Steven Dobrowolski; Fiscal Year: 2007
    ..Diseases involving the urea cycle are clinically manifest by symptoms diverse as neonatal hyperammonemic coma to postpartum psychosis...
  40. Role of chemokines in astro-neuronal activation in cerebral malaria
    Monique Stins; Fiscal Year: 2009
    ..of up to 200 million episodes in Africa alone and a severe complication is cerebral malaria (CM), often leading to coma and death. A hallmark of human cerebral malaria (CM) is the sequestration of P...
  41. The role of apoE and APOE genotype in amyloid-beta clearance after TBI
    Mark P Burns; Fiscal Year: 2013
    ..TBI) the human APOE-[unreadable]4 (APOE4) gene polymorphism is associated with increased mortality, increased coma time, poor prognosis, and an increased risk of late-onset Alzheimer's disease (AD)...
  42. Molecular mechanisms of Shiga toxin action in the mammal central nervous system
    Fumiko Obata; Fiscal Year: 2011
    ..of symptoms as cortical blindness, poor fine-motor coordination, seizures and changes in consciousness including coma. Importantly, CNS manifestations often associate with mortality or severe sequelae...
  43. Traumatic Brain Injury Clinical Trials Network
    Howard M Eisenberg; Fiscal Year: 2010
    ..the last academic year STC admitted 735 patients with traumatic brain injury, 250 were considered severe (Glasgow Coma Score [GCS] 3 to 8), 66 considered moderately injured (GCS 9 to 12), 147 were less than 21 years of age, 382 were ..
  44. Optical aberration and visual performance in highly aberrated eyes
    Raymond A Applegate; Fiscal Year: 2012
    ..soft contact lenses that compensate for both low order aberrations (sphere, cylinder) and high order aberrations (coma, trefoil, spherical aberration, etc) of the individual highly aberrated eye have been demonstrated on a small scale ..
  45. Brain Insulin Action Regulates Hypothalamic Glucose Sensing
    ..and triggers a "fight-or-flight" stress response to rapidly increase blood sugar and prevent a seizure or coma. Unfortunately, people with Type 1 diabetes do not detect low blood glucose as well as non-diabetic individuals and ..
    Nancy Temkin; Fiscal Year: 2004
    ..Patients with moderate or severe head injury (post-resuscitation Glasgow Coma Scale 3-12 or having an early craniotomy) are randomized to receive moderate doses of magnesium sulfate or placebo...
  47. Neurobehavioral effects of adolescent GHB
    Ratna Sircar; Fiscal Year: 2007
    ..dizziness, confusion, agitation, hallucination, and at very high doses respiratory depression, unconsciousness, coma and death...
    William Coplin; Fiscal Year: 1999
    ..The study will randomly assign, within 24 hours of ictus, 92 TBI patients, Glasgow Coma Scale score less than or equal to 9, with midline shift greater than the size of a surgically removable hematoma...
  49. Redefining Cerebral Malaria
    Terrie Taylor; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): 'Cerebral malaria'is a clinical syndrome consisting of coma not attributable to convulsions, hypoglycemia, or meningitis in patients with P. falciparum parasitemia...
    WILLIAM CRUCE; Fiscal Year: 1990
    ..g. of sleep, alertness, respiration, blood pressure, and pain. Clinically, it has been implicated in coma, sleep disorders, motor disorders, and epilepsy...
    Michael Norenberg; Fiscal Year: 2000
    Jacek Rozga; Fiscal Year: 2003
    ..For many years, it was assumed that toxins, which cause coma in hepatic failure, are small (<5 kDa) dialyzable molecules...
    Guy Clifton; Fiscal Year: 1999
    ..Brain Injury Study: Hypothermia (NABIS:H) has been examining the effect of moderate hypothermia (33 ) on (Glasgow Coma Score 3-8) since October, 1994...
    Rebecca Ichord; Fiscal Year: 1999
    ..Hypoglycemic injury in mature brain is related to duration of coma, which heralds the onset of energy failure...
  55. Pediatric Mild Head Injury: Definition and Consequences
    Ronald Maio; Fiscal Year: 2004
    ..Glasgow Coma Scale scores will be 13-15 with no intracranial pathology on any neuroimaging studies...
    BAHJAT FARAJ; Fiscal Year: 1980
    ..was substantially raised and the degree of hypertyraminemia correlated significantly with duration and stage of coma in these patients as well as with concentrations of its precursor, the amino acid, tyrosine...
    James Olson; Fiscal Year: 1993
    ..encephalopathy (HE) is a complex medical condition involving an acute degeneration in mental status leading to coma and death if untreated. Cerebral edema and elevated intracranial pressure is a consistent finding in HE...
  58. Screening for antivirals against flaviviruses
    PAUL OLIVO; Fiscal Year: 2003
    ..Severe cases may also show shock, nervous system malfunction, coma, delirium, seizures and renal failure. Some VHF agents have been suspect for abuse in biowarfare/bioterrorism...
  59. Induction of Tissue Factor by Patient Sera in HUS
    Eric Grabowski; Fiscal Year: 2007
    ..the acute phase of the HUS, some 3 to 5% of patients die, while as many as 25% also suffer stroke, seizures, and/or coma. At present this condition has little established pathophysiology, aside from an association with shiga toxin ..
    Martin Klinger; Fiscal Year: 1991
    ..The disorder is characterized by severe plasma protein imbalance, coma, loss of detoxification ability and subsequent accumulation of toxic metabolic products...
    Brendan Lee; Fiscal Year: 2000
    ..They present in the neonatal period with hyperammonemic coma and result in long-term neurological and developmental deficits...
  62. Cognitive Impairment in the ICU: Evaluation and Outcomes
    E Ely; Fiscal Year: 2005
    DESCRIPTION (From the application): Global deficits in cognition in the form of delirium, stupor, or coma are extremely common and hazardous in older ICU patients...