aphasia

Summary

Summary: A cognitive disorder marked by an impaired ability to comprehend or express language in its written or spoken form. This condition is caused by diseases which affect the language areas of the dominant hemisphere. Clinical features are used to classify the various subtypes of this condition. General categories include receptive, expressive, and mixed forms of aphasia.

Top Publications

  1. ncbi Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison
    Elizabeth Jefferies
    School of Psychological Sciences, University of Manchester, Manchester, UK
    Brain 129:2132-47. 2006
  2. pmc Using transcranial direct-current stimulation to treat stroke patients with aphasia
    Julie M Baker
    Department of Communication Sciences and Disorders, Williams Brice Building, 1621 Greene St, University of South Carolina, Columbia, SC 29208, USA
    Stroke 41:1229-36. 2010
  3. pmc The arcuate fasciculus and the disconnection theme in language and aphasia: history and current state
    Marco Catani
    Natbrainlab, Section of Brain Maturation, King s College London, Institute of Psychiatry, London, UK
    Cortex 44:953-61. 2008
  4. pmc Anterior temporal involvement in semantic word retrieval: voxel-based lesion-symptom mapping evidence from aphasia
    Myrna F Schwartz
    Moss Rehabilitation Research Institute, MossRehab 4th fl Sley, 1200 West Tabor Road, Philadelphia, PA 19141, USA
    Brain 132:3411-27. 2009
  5. pmc Improved picture naming in aphasia patients treated with cathodal tDCS to inhibit the right Broca's homologue area
    Eun Kyoung Kang
    Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea Department of Rehabilitation Medicine, Seoul Bukbu Geriatric Hospital, Seoul, South Korea
    Restor Neurol Neurosci 29:141-52. 2011
  6. doi Elucidating the nature of deregulated semantic cognition in semantic aphasia: evidence for the roles of prefrontal and temporo-parietal cortices
    Krist A Noonan
    University of Manchester, Manchester, UK
    J Cogn Neurosci 22:1597-613. 2010
  7. ncbi Lesion analysis of the brain areas involved in language comprehension
    Nina F Dronkers
    VA Northern California Health Care System, Martinez, CA 94553, USA
    Cognition 92:145-77. 2004
  8. ncbi A proposed regional hierarchy in recovery of post-stroke aphasia
    W D Heiss
    Max Planck Institute for Neurological Research, University of Cologne, Germany
    Brain Lang 98:118-23. 2006
  9. pmc Activity in preserved left hemisphere regions predicts anomia severity in aphasia
    Julius Fridriksson
    Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, USA
    Cereb Cortex 20:1013-9. 2010
  10. doi Association between therapy outcome and right-hemispheric activation in chronic aphasia
    Maria Richter
    Department of Biological and Clinical Psychology, Friedrich Schiller University, Am Steiger 3 1 D 07743 Jena, Germany
    Brain 131:1391-401. 2008

Research Grants

  1. Katherine P Rankin; Fiscal Year: 2016
  2. Neural substrates for matching hearing to utterance
    Darcy B Kelley; Fiscal Year: 2012
  3. Margaret A Naeser; Fiscal Year: 2016
  4. Shannon C Mauszycki; Fiscal Year: 2016
  5. David L Sheinberg; Fiscal Year: 2016
  6. Toward a multi-modal and multi-level analysis of Chinese aphasic discourse
    PAK HIN ANTHONY KONG; Fiscal Year: 2013
  7. Speech Perception Assessment and Training System for Aphasia Rehabilitation
    James D Miller; Fiscal Year: 2010
  8. Functional Architecture of Human Speech Motor Cortex
    Edward Chang; Fiscal Year: 2011
  9. JENNIFER LOUISE WHITWELL; Fiscal Year: 2016
  10. Promoting Functional Communication Abilities in Aphasia with Virtual Reality
    Nadine Martin; Fiscal Year: 2013

Detail Information

Publications395 found, 100 shown here

  1. ncbi Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison
    Elizabeth Jefferies
    School of Psychological Sciences, University of Manchester, Manchester, UK
    Brain 129:2132-47. 2006
    ..dementia (SD) is characterized by atrophy of the anterior temporal lobes whilst poor comprehension in stroke aphasia is associated with prefrontal or temporal-parietal infarcts...
  2. pmc Using transcranial direct-current stimulation to treat stroke patients with aphasia
    Julie M Baker
    Department of Communication Sciences and Disorders, Williams Brice Building, 1621 Greene St, University of South Carolina, Columbia, SC 29208, USA
    Stroke 41:1229-36. 2010
    ..primarily of the left frontal cortex, is associated with improved naming performance in stroke patients with aphasia. Our aim was to determine whether anodal transcranial direct-current stimulation (tDCS), a method thought to ..
  3. pmc The arcuate fasciculus and the disconnection theme in language and aphasia: history and current state
    Marco Catani
    Natbrainlab, Section of Brain Maturation, King s College London, Institute of Psychiatry, London, UK
    Cortex 44:953-61. 2008
    Few themes have been more central to neurological models of aphasia than the disconnection paradigm and the role of the arcuate fasciculus...
  4. pmc Anterior temporal involvement in semantic word retrieval: voxel-based lesion-symptom mapping evidence from aphasia
    Myrna F Schwartz
    Moss Rehabilitation Research Institute, MossRehab 4th fl Sley, 1200 West Tabor Road, Philadelphia, PA 19141, USA
    Brain 132:3411-27. 2009
    ..Semantic errors were obtained from 64 individuals with post-stroke aphasia, who also underwent high-resolution structural brain scans...
  5. pmc Improved picture naming in aphasia patients treated with cathodal tDCS to inhibit the right Broca's homologue area
    Eun Kyoung Kang
    Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea Department of Rehabilitation Medicine, Seoul Bukbu Geriatric Hospital, Seoul, South Korea
    Restor Neurol Neurosci 29:141-52. 2011
    ..cathodal transcranial DC stimulation (ctDCS), a technique that decreases excitability of stimulated cortical sites, applied over a healthy right Broca's homologue area could improve picture naming in patients with post-stroke aphasia.
  6. doi Elucidating the nature of deregulated semantic cognition in semantic aphasia: evidence for the roles of prefrontal and temporo-parietal cortices
    Krist A Noonan
    University of Manchester, Manchester, UK
    J Cogn Neurosci 22:1597-613. 2010
    ..In contrast, multimodal semantic impairment in aphasic patients (semantic aphasia [SA]) reflects damage to the control component of semantic cognition [Jefferies, E., & Lambon Ralph, M. A...
  7. ncbi Lesion analysis of the brain areas involved in language comprehension
    Nina F Dronkers
    VA Northern California Health Care System, Martinez, CA 94553, USA
    Cognition 92:145-77. 2004
    ..These results are consistent with those seen in recent functional neuroimaging studies and offer complementary data in the effort to understand the brain areas underlying language comprehension...
  8. ncbi A proposed regional hierarchy in recovery of post-stroke aphasia
    W D Heiss
    Max Planck Institute for Neurological Research, University of Cologne, Germany
    Brain Lang 98:118-23. 2006
    Activation studies in patients with aphasia due to stroke or tumours in the dominant hemisphere have revealed effects of disinhibition in ipsilateral perilesional and in contralateral homotopic cortical regions, referred to as collateral ..
  9. pmc Activity in preserved left hemisphere regions predicts anomia severity in aphasia
    Julius Fridriksson
    Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, USA
    Cereb Cortex 20:1013-9. 2010
    Understanding the neural mechanism that supports preserved language processing in aphasia has implications for both basic and applied science...
  10. doi Association between therapy outcome and right-hemispheric activation in chronic aphasia
    Maria Richter
    Department of Biological and Clinical Psychology, Friedrich Schiller University, Am Steiger 3 1 D 07743 Jena, Germany
    Brain 131:1391-401. 2008
    ..areas in response to language tasks in chronic non-fluent aphasic patients before and after constraint-induced aphasia therapy (CIAT). In particular, we analysed the relation between brain responses and therapy outcome...
  11. pmc The right hemisphere supports but does not replace left hemisphere auditory function in patients with persisting aphasia
    Sundeep Teki
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, UK
    Brain 136:1901-12. 2013
    ..Despite this presumed compensatory shift in network connectivity, the patients remain significantly impaired...
  12. pmc Damage to ventral and dorsal language pathways in acute aphasia
    Dorothee Kümmerer
    Department of Neurology, University Medical Centre Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Brain 136:619-29. 2013
    ..Particularly, this is the first lesion study demonstrating that task performance on auditory comprehension measures requires an interaction between temporal and prefrontal brain regions via the ventral extreme capsule pathway...
  13. ncbi Normative data on the Korean version of the Western Aphasia Battery
    Hyanghee Kim
    Graduate Program in Speech Pathology and Department of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea
    J Clin Exp Neuropsychol 26:1011-20. 2004
    The study aimed to describe the properties of the Korean version of the Western Aphasia Battery (hereinafter K-WAB) and to present the normative data of normal individuals and patients...
  14. ncbi Intensity of aphasia therapy, impact on recovery
    Sanjit K Bhogal
    Department of Physical Medicine and Rehabilitation, University of Western Ontario, St Joseph s Health Care London, Parkwood Hospital, Ontario, Canada
    Stroke 34:987-93. 2003
    It has been speculated that the conflicting results demonstrated across poststroke aphasia therapy studies might be related to differences in intensity of therapy provided across studies...
  15. doi Noninvasive brain stimulation in the treatment of aphasia: exploring interhemispheric relationships and their implications for neurorehabilitation
    Evangelia G Chrysikou
    University of Pennsylvania, Department of Psychology, Center for Cognitive Neuroscience, Philadelphia, PA, USA
    Restor Neurol Neurosci 29:375-94. 2011
    b>Aphasia is a common consequence of unilateral stroke, typically involving perisylvian regions of the left hemisphere...
  16. doi Transcranial direct current stimulation (tDCS) for improving aphasia in patients after stroke
    Bernhard Elsner
    Department of Public Health, Dresden Medical School, Technical University Dresden, Dresden, Germany
    Cochrane Database Syst Rev . 2013
    Stroke is one of the leading causes of disability worldwide. Aphasia among stroke survivors is common. Current speech and language therapy (SLT) strategies have only limited effectiveness in improving aphasia...
  17. doi Wernicke's aphasia reflects a combination of acoustic-phonological and semantic control deficits: a case-series comparison of Wernicke's aphasia, semantic dementia and semantic aphasia
    Holly Robson
    Neuroscience and Aphasia Research Unit NARU, University of Manchester, Manchester, UK
    Neuropsychologia 50:266-75. 2012
    Wernicke's aphasia (WA) is the classical neurological model of comprehension impairment and, as a result, the posterior temporal lobe is assumed to be critical to semantic cognition...
  18. ncbi Neural substrates of spoken language rehabilitation in an aphasic patient: an fMRI study
    A Leger
    INSERM U 455 and Department of Neurology, CHU Purpan, Toulouse, France
    Neuroimage 17:174-83. 2002
    ..Speech therapy effect was associated with activations in Broca's area and the left supra-marginal gyrus, which might reflect a therapy-induced phonological compensatory strategy for naming...
  19. pmc Non-fluent aphasia and neural reorganization after speech therapy: insights from human sleep electrophysiology and functional magnetic resonance imaging
    S Sarasso
    Department of Psychiatry, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    Arch Ital Biol 148:271-8. 2010
    ..induced by a single exposure to a therapeutic session of IMITATE (Intensive Mouth Imitation and Talking for Aphasia Therapeutic Effects), a behavioral therapy used for recovery in patients with post-stroke aphasia...
  20. pmc Research with transcranial magnetic stimulation in the treatment of aphasia
    Paula I Martin
    Aphasia Research Center 12 A, VA Boston Healthcare System, Boston, MA 02130, USA
    Curr Neurol Neurosci Rep 9:451-8. 2009
    ..rTMS) has been used to improve language behavior, including naming, in stroke patients with chronic, nonfluent aphasia. Part 1 of this article reviews functional imaging studies related to language recovery in aphasia...
  21. doi Bilingual aphasia and language control: a follow-up fMRI and intrinsic connectivity study
    Jubin Abutalebi
    Vita Salute San Raffaele University and Division of Neuroscience, San Raffaele Scientific Institute, Milan, National Neuroscience Institute, Italy
    Brain Lang 109:141-56. 2009
    In a world that is becoming more multilingual, bilingual aphasia is a clinical problem with a major clinical impact...
  22. ncbi The latest on functional imaging studies of aphasic stroke
    Cathy J Price
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
    Curr Opin Neurol 18:429-34. 2005
    ..In this review of studies published between January 2004 and February 2005, we discuss imaging studies of speech production and comprehension in patients with aphasia after left hemisphere stroke.
  23. ncbi Right anterior superior temporal activation predicts auditory sentence comprehension following aphasic stroke
    Jenny Crinion
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK
    Brain 128:2858-71. 2005
    ..activation in 18 neurologically normal subjects and 17 patients with left hemisphere stroke and a history of aphasia. Activation for listening to meaningful stories relative to meaningless reversed speech was identified in the ..
  24. ncbi Action comprehension in aphasia: linguistic and non-linguistic deficits and their lesion correlates
    Ayse Pinar Saygin
    Department of Cognitive Science, University of California, San Diego, 9500 Gilman Drive 0515, La Jolla, CA 92093 0515, USA
    Neuropsychologia 42:1788-804. 2004
    ..Similar findings have been reported in electrophysiological and neuroimaging studies. Our findings now also lend neuropsychological support to an embodied view of brain organization for action processing...
  25. doi Psychological distress after stroke and aphasia: the first six months
    Katerina Hilari
    Department of Language and Communication Science, School of Community and Health Sciences, City University London, London, UK
    Clin Rehabil 24:181-90. 2010
    We explored the factors that predicted psychological distress in the first six months post stroke in a sample including people with aphasia.
  26. ncbi Acute caudate vascular lesions
    E Kumral
    Division of Cerebrovascular and Neuropsychology Unit, Department of Neurology, Faculty of Medicine, Ege University, Izmir, Turkey
    Stroke 30:100-8. 1999
    ..We sought to evaluate demographic features, risk factors, clinical profiles, and behavioral abnormalities in patients with caudate lesion, either with infarct or with hemorrhage involving the caudate nucleus...
  27. ncbi Aphasia in acute stroke and relation to outcome
    A C Laska
    Division of Internal Medicine, Karolinska Institutet, Danderyd Hospital, Sweden
    J Intern Med 249:413-22. 2001
    The natural course of aphasia in unselected, consecutive stroke patients is not well established...
  28. pmc Different impairments of semantic cognition in semantic dementia and semantic aphasia: evidence from the non-verbal domain
    Faye Corbett
    Neuroscience and Aphasia Research Unit NARU, School of Psychological Sciences, University of Manchester, Manchester, UK
    Brain 132:2593-608. 2009
    ..a deficit of cognitive control produces multi-modal semantic impairment in a subset of patients with stroke aphasia following damage involving the left prefrontal cortex or regions in and around the temporoparietal area; this ..
  29. ncbi Neural basis of category-specific semantic deficits for living things: evidence from semantic dementia, HSVE and a neural network model
    Matthew A Lambon Ralph
    School of Psychological Sciences, University of Manchester, Manchester, UK
    Brain 130:1127-37. 2007
    ..Three novel predictions from this model were tested and confirmed, thereby adding weight to the hypothesis that both type and distribution of pathology can be critical in producing neuropsychological phenomena...
  30. pmc Mechanisms of aphasia recovery after stroke and the role of noninvasive brain stimulation
    Roy H Hamilton
    University of Pennsylvania, Department of Neurology, Center for Cognitive Neuroscience, Philadelphia, United States
    Brain Lang 118:40-50. 2011
    One of the most frequent symptoms of unilateral stroke is aphasia, the impairment or loss of language functions...
  31. pmc Impaired speech repetition and left parietal lobe damage
    Julius Fridriksson
    Department of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208, USA
    J Neurosci 30:11057-61. 2010
    Patients with left hemisphere damage and concomitant aphasia usually have difficulty repeating others' speech...
  32. ncbi Improved picture naming in chronic aphasia after TMS to part of right Broca's area: an open-protocol study
    Margaret A Naeser
    Department of Neurology, Harold Goodglass Boston University Aphasia Research Center, Boston University School of Medicine and the Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA
    Brain Lang 93:95-105. 2005
    Functional imaging studies with nonfluent aphasia patients have observed "over-activation" in right (R) language homologues. This may represent a maladaptive strategy; suppression may result in language improvement...
  33. pmc Reliability of fMRI for studies of language in post-stroke aphasia subjects
    Kenneth P Eaton
    Imaging Research Center, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    Neuroimage 41:311-22. 2008
    ..These quantitative measures of inter-scan variability support the proposed use of these fMRI paradigms for longitudinal mapping of neural reorganization of language processing following left hemispheric insult...
  34. ncbi Functional re-recruitment of dysfunctional brain areas predicts language recovery in chronic aphasia
    Marcus Meinzer
    Department of Clinical Psychology and Neuropsychology, University of Konstanz, Universitatsstrasse 10, Konstanz, Germany
    Neuroimage 39:2038-46. 2008
    ..In eleven chronic aphasia patients, we administered a short-term intensive language training to improve language functions and to induce ..
  35. doi Right hemisphere activation in recovery from aphasia: lesion effect or function recruitment?
    G Raboyeau
    Pôle Neurosciences CHU Toulouse, Inserm UMR S825, IFR 96, Universités de Toulouse, Toulouse, France
    Neurology 70:290-8. 2008
    ..that specific right hemispheric regions can compensate deficits induced by left hemispheric lesions in vascular aphasia. In particular, the right inferior frontal cortex might take part in lexical retrieval in patients presenting ..
  36. ncbi Cortical language activation in stroke patients recovering from aphasia with functional MRI
    Y Cao
    NMR Research Center, Department of Neurology, Henry Ford Health Sciences Center, Case Western Reserve University, Detroit, MI, USA
    Stroke 30:2331-40. 1999
    Two mechanisms for recovery from aphasia, repair of damaged language networks and activation of compensatory areas, have been proposed...
  37. ncbi Constraint-induced therapy of chronic aphasia after stroke
    F Pulvermuller
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Stroke 32:1621-6. 2001
    Patients with chronic aphasia were assigned randomly to a group to receive either conventional aphasia therapy or constraint-induced (CI) aphasia therapy, a new therapeutic technique requiring intense practice over a relatively short ..
  38. ncbi Aphasia after stroke: type, severity and prognosis. The Copenhagen aphasia study
    Palle Møller Pedersen
    Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark
    Cerebrovasc Dis 17:35-43. 2004
    To determine the types, severity and evolution of aphasia in unselected, acute stroke patients and evaluate potential predictors for language outcome 1 year after stroke.
  39. doi Speech and language therapy for aphasia following stroke
    Marian C Brady
    Nursing, Midwifery and AlliedHealth Professions ResearchUnit, Glasgow Caledonian University, Glasgow, UK
    Cochrane Database Syst Rev . 2012
    b>Aphasia is an acquired language impairment following brain damage that affects some or all language modalities: expression and understanding of speech, reading and writing...
  40. doi Incidence and profile of inpatient stroke-induced aphasia in Ontario, Canada
    Laura Dickey
    Aphasia Institute incorporating the Pat Arato Aphasia Centre, Toronto, ON, Canada
    Arch Phys Med Rehabil 91:196-202. 2010
    To determine the incidence rate of inpatient stroke-induced aphasia in Ontario, Canada, and to examine the demographic and clinical characteristics for stroke patients with and without aphasia.
  41. doi Lichtheim 2: synthesizing aphasia and the neural basis of language in a neurocomputational model of the dual dorsal-ventral language pathways
    Taiji Ueno
    Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester M139PL, UK
    Neuron 72:385-96. 2011
    ....
  42. ncbi [Acupuncture therapy for apoplectic aphasia: a systematic review]
    Yong Pang
    Department of Acupuncture, The First Affiliated Hospital of Guanngxi TCM University, Nanning 530023, China
    Zhongguo Zhen Jiu 30:612-6. 2010
    To assess the therapeutic effect of acupuncture for apoplectic aphasia.
  43. doi Default-mode network functional connectivity in aphasia: therapy-induced neuroplasticity
    Karine Marcotte
    Unité de Neuroimagerie Fonctionnelle, Research Center, Institut Universitaire de Geriatrie de Montreal, 4565 Queen Mary Road, Montreal, Quebec, Canada
    Brain Lang 124:45-55. 2013
    Previous research on participants with aphasia has mainly been based on standard functional neuroimaging analysis...
  44. ncbi A physiological change in the homotopic cortex following left posterior temporal lobe infarction
    Alexander Leff
    Medical Research Council Cyclotron Unit, Clinical Sciences Centre, Hammersmith Hospital, Imperial College School of Medicine, London, United Kingdom
    Ann Neurol 51:553-8. 2002
    ..The results demonstrated a change in physiological responsiveness in the contralateral homotopic cortex after posterior temporal infarction...
  45. pmc Auditory object cognition in dementia
    Johanna C Goll
    Dementia Research Centre, Institute of Neurology, University College London, 8 11 Queen Square, London WC1N 3BG, United Kingdom
    Neuropsychologia 49:2755-65. 2011
    ..syndromes comprising clinically diagnosed typical amnestic Alzheimer's disease (AD; n=21), progressive nonfluent aphasia (PNFA; n=5), logopenic progressive aphasia (LPA; n=7) and aphasia in association with a progranulin gene mutation ..
  46. ncbi Category and letter fluency in semantic dementia, primary progressive aphasia, and Alzheimer's disease
    Cecile A Marczinski
    Department of Cognitive Neurology, St Joseph s Hospital, University of Western Ontario, London, Ont, Canada
    Brain Lang 97:258-65. 2006
    ..Patients with semantic dementia, primary progressive aphasia, and Alzheimer's disease were compared with elderly controls on tasks of category and letter fluency, with number ..
  47. ncbi Functional communication and executive function in aphasia
    Julius Fridriksson
    Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, USA
    Clin Linguist Phon 20:401-10. 2006
    ..study was to investigate the relationship between functional communication and executive function ability in aphasia. Twenty-five participants with aphasia underwent examination with an extensive test battery including measures of ..
  48. doi Therapy-induced neuroplasticity in chronic aphasia
    Karine Marcotte
    Unité de Neuroimagerie Fonctionnelle, Research Centre Institut Universitaire de Gériatrie de Montréal, 4565 Queen Mary Road, Montreal, Quebec, Canada
    Neuropsychologia 50:1776-86. 2012
    Research on the neural substrate of aphasia recovery has consistently increased since the advent of functional neuroimaging...
  49. ncbi Stroke rehabilitation using noninvasive cortical stimulation: aphasia
    Veit Mylius
    Université Paris Est Créteil, Faculte de Medecine, EA 4391, Creteil, France
    Expert Rev Neurother 12:973-82. 2012
    Poststroke aphasia results from the lesion of cortical areas involved in the motor production of speech (Broca's aphasia) or in the semantic aspects of language comprehension (Wernicke's aphasia)...
  50. ncbi The provision of health information to stroke patients within an acute hospital setting: what actually happens and how do patients feel about it?
    Kimberley Knight
    Communication Disability in Ageing Research Centre, School of Health and Rehabilitation Sciences, The University of Queensland
    Top Stroke Rehabil 13:78-98. 2006
    ..A further aim was to determine if patients with aphasia were disadvantaged in their receipt of information...
  51. doi An fMRI study of acupuncture-induced brain activation of aphasia stroke patients
    Geng Li
    Hong Kong Time Medical System and Rejuvenis International Ltd, Hong Kong Science Park, Shatin, Hong Kong, China
    Complement Ther Med 19:S49-59. 2011
    This investigation aims to test the effect of acupuncture on word generation activation (WGA) in post-stroke aphasia patients...
  52. doi Neuroscience insights improve neurorehabilitation of poststroke aphasia
    Marcelo L Berthier
    Unit of Cognitive Neurology and Aphasia, Centro de Investigaciones Médico Sanitarias, University of Malaga, Campus Teatinos, Spain
    Nat Rev Neurol 7:86-97. 2011
    ..and exploitation of residual neurological capacities can aid neurorehabilitation of patients with poststroke aphasia, and progress in basic neuroscience research indicates that the language system of the human brain is ..
  53. doi Drug therapy of post-stroke aphasia: a review of current evidence
    Marcelo L Berthier
    Unit of Cognitive Neurology and Aphasia, Centro de Investigaciones Médico Sanitarias CIMES, University of Malaga, C Marques de Beccaria 3, 29010 Malaga, Spain
    Neuropsychol Rev 21:302-17. 2011
    This review considers the role of drug therapy in the treatment of post-stroke aphasia, the evidence for efficacy of different agents, and the theory-based explanations of drug-related benefits for aphasia rehabilitation...
  54. doi Speech perceived through a damaged temporal window: lessons from word deafness and aphasia
    Gerry A Stefanatos
    Department of Communication Sciences and Disorders, Temple University, Philadelphia, Pennsylvania 19122, USA
    Semin Speech Lang 29:239-52. 2008
    ..The implications of these findings for approaches to the treatment of word deafness are discussed...
  55. doi Measuring verbal and non-verbal communication in aphasia: reliability, validity, and sensitivity to change of the Scenario Test
    Ineke van der Meulen
    Rijndam Rehabilitation Centre, Rotterdam, The Netherlands
    Int J Lang Commun Disord 45:424-35. 2010
    ..explores the psychometric qualities of the Scenario Test, a new test to assess daily-life communication in severe aphasia. The test is innovative in that it: (1) examines the effectiveness of verbal and non-verbal communication; and (2)..
  56. ncbi Activation of intentional mechanisms through utilization of nonsymbolic movements in aphasia rehabilitation
    Katherine Richards
    McKnight Brain Institute at the University of Florida, Gainesville, FL, USA
    J Rehabil Res Dev 39:445-54. 2002
    ..Deficits demonstrated in nonfluent aphasia may be a result of a disconnection between or damage to the initiation (intention) and production mechanisms in ..
  57. doi Stroke aphasia: 1,500 consecutive cases
    Alexandre Croquelois
    Department of Neurorehabilitation and Neuropsychology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Cerebrovasc Dis 31:392-9. 2011
    To study the characteristics of vascular aphasia in a cohort of patients with a first-ever stroke.
  58. pmc The prognosis for aphasia in stroke
    Matthew B Maas
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Stroke Cerebrovasc Dis 21:350-7. 2012
    b>Aphasia is a disabling chronic stroke symptom, but the prognosis for patients presenting with aphasia in the hyperacute window has not been well characterized...
  59. doi Long term language recovery subsequent to low frequency rTMS in chronic non-fluent aphasia
    Caroline H S Barwood
    Centre for Neurogenic Communication Disorders Research, School of Health and Rehabilitation Sciences, The University of Queensland, QLD, Australia
    NeuroRehabilitation 32:915-28. 2013
    ..rTMS) has emerged as a potential therapeutic tool for the rehabilitation of language in chronic non-fluent aphasia post-stroke...
  60. doi Neurobiology of language recovery after stroke: lessons from neuroimaging studies
    Dorothee Saur
    Language and Aphasia Laboratory, Department of Neurology, University of Leipzig, Leipzig, Germany
    Arch Phys Med Rehabil 93:S15-25. 2012
    ..The review is complemented by an introductory section on language organization in the healthy brain...
  61. pmc Effectiveness of enhanced communication therapy in the first four months after stroke for aphasia and dysarthria: a randomised controlled trial
    Audrey Bowen
    HCD, Ellen Wilkinson Building, University of Manchester MAHSC, Manchester Academic Health Science Centre, Manchester M13 9PL, UK
    BMJ 345:e4407. 2012
    ..To assess the effectiveness of enhanced communication therapy in the first four months after stroke compared with an attention control (unstructured social contact)...
  62. doi The use of the Bilingual Aphasia Test for assessment and transcranial direct current stimulation to modulate language acquisition in minimally verbal children with autism
    Harry D Schneider
    Program for Cognitive Sciences, Columbia University Medical Center, New York, NY, USA
    Clin Linguist Phon 25:640-54. 2011
    ..We modified the English version of the Bilingual Aphasia Test (BAT) to test only basic canonical subject-verb-object sentences...
  63. pmc The use of non-invasive brain stimulation techniques to facilitate recovery from post-stroke aphasia
    Gottfried Schlaug
    Department of Neurology, Neuroimaging and Stroke Recovery Laboratories, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Palmer 127, Boston, MA 02215, USA
    Neuropsychol Rev 21:288-301. 2011
    b>Aphasia is a common symptom after left hemispheric stroke...
  64. ncbi Re-visiting "semantic facilitation" of word retrieval for people with aphasia: facilitation yes but semantic no
    David Howard
    School of Education, Communication and Language Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Cortex 42:946-62. 2006
    ..that cannot be named at pre-test results in improved naming relative to untreated control items for people with aphasia. This paper replicates and extends this finding and investigates its source...
  65. pmc Preservation and modulation of specific left hemisphere regions is vital for treated recovery from anomia in stroke
    Julius Fridriksson
    Department of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina 29208, USA
    J Neurosci 30:11558-64. 2010
    ..damage and changes in cortical activation as predictors of language-treatment outcome in patients with chronic aphasia caused by stroke...
  66. ncbi Measuring quality of life in people with aphasia: the Stroke Specific Quality of Life Scale
    K Hilari
    Department of Language and Communication Science, City University, Northampton Square, London EC1V 0HB
    Int J Lang Commun Disord 36:86-91. 2001
    ..currently running a medium scale study (80 participants) which aims to explore the HRQOL of people with long-term aphasia and to assess the psychometric properties and the acceptability of the Stroke Specific Quality of Life Scale (SS-..
  67. pmc Functional MRI of language in aphasia: a review of the literature and the methodological challenges
    Bruce Crosson
    Department of Veterans Affairs Rehabilitation Research and Development Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, Florida, USA
    Neuropsychol Rev 17:157-77. 2007
    ..and other functional neuroimaging techniques have been used to study reorganization of language substrates in aphasia. The resulting controversy regarding whether the right or the left hemisphere supports language recovery and ..
  68. ncbi Outcome assessment in aphasia: a survey
    Nina Simmons-Mackie
    Department of Communication Sciences and Disorders, Southeastern Louisiana University, 59020 Highway 433, Slidell, LA 70460, USA
    J Commun Disord 38:1-27. 2005
    ..been a marked increase in attention to the measurement of "outcomes" after speech-language intervention for adult aphasia. Consumers, speech-language pathologists (SLPs), and funding sources desire evidence of therapy outcomes that ..
  69. doi Semantic diversity accounts for the "missing" word frequency effect in stroke aphasia: insights using a novel method to quantify contextual variability in meaning
    Paul Hoffman
    School of Psychological Sciences, Zochonis Building, University of Manchester, Oxford Road, Manchester, M13 9PL, UK
    J Cogn Neurosci 23:2432-46. 2011
    ..Puzzlingly, frequency effects are often absent in stroke aphasia, challenging the assumption that word frequency influences the behavior of any computational system...
  70. ncbi Word learning can be achieved without feedback: implications for aphasia therapy
    Caterina Breitenstein
    Department of Neurology, University of Munster, Munster, Germany
    Restor Neurol Neurosci 22:445-58. 2004
    Children acquire new words through exposure, without the necessity for explicit feedback by caregivers. In aphasia therapy, feedback to the patient is considered an important asset even though the empirical base demonstrating superior ..
  71. ncbi Recovery and treatment of aphasia after stroke: functional imaging studies
    Jenny T Crinion
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, London, UK
    Curr Opin Neurol 20:667-73. 2007
    In this review of papers published between May 2006 and May 2007, we discuss functional neuroimaging studies of recovery and treatment of patients with aphasia after stroke.
  72. doi Reporting on psychological well-being of older adults with chronic aphasia in the context of unaffected peers
    Madeline Cruice
    Language and Communication Science, City University, London EC1V 0HB, UK
    Disabil Rehabil 33:219-28. 2011
    ..Much is known about the significant emotional, social and psychological consequences of aphasia after stroke; however, little is known about the individuals' psychological well-being...
  73. doi Contribution of the left and right inferior frontal gyrus in recovery from aphasia. A functional MRI study in stroke patients with preserved hemodynamic responsiveness
    Casper A M M van Oers
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Neuroimage 49:885-93. 2010
    The relative contribution of dominant and non-dominant language networks to recovery from aphasia is a matter of debate...
  74. doi Communication partner training in aphasia: a systematic review
    Nina Simmons-Mackie
    Department of Communication Sciences and Disorders, Southeastern Louisiana University, Hammond, USA
    Arch Phys Med Rehabil 91:1814-37. 2010
    To describe the effects of communication partner training on persons with aphasia and their communication partners...
  75. pmc Research with rTMS in the treatment of aphasia
    Margaret A Naeser
    Veterans Affairs Boston Healthcare System and the Harold Goodglass Boston University Aphasia Research Center, Department of Neurology, Boston University School of Medicine, Boston, MA 02130, USA
    Restor Neurol Neurosci 28:511-29. 2010
    This review of our research with rTMS to treat aphasia contains four parts: Part 1 reviews functional brain imaging studies related to recovery of language in aphasia with emphasis on nonfluent aphasia...
  76. ncbi Recovery from post-stroke aphasia: lessons from brain imaging and implications for rehabilitation and biological treatments
    Marcelo L Berthier
    Unit of Cognitive Neurology and Aphasia, Centro de Investigaciones Médico Sanitarias CIMES, University of Malaga, Spain
    Discov Med 12:275-89. 2011
    b>Aphasia, a condition defined as the partial or complete loss of language function after brain damage, is one of the most devastating cognitive deficits produced by stroke lesions...
  77. ncbi Pharmacotherapy of aphasia: myth or reality?
    Xavier De Boissezon
    INSERM U455, CHU Purpan, Toulouse 31059, France
    Brain Lang 102:114-25. 2007
    Pharmacotherapy of aphasia had been discussed for the last twenty years with first bromocriptine and amphetamine and then serotoninergic, GABAergic and cholinergic agents...
  78. ncbi Effects of gesture+verbal treatment for noun and verb retrieval in aphasia
    Anastasia M Raymer
    Department of ESSE, Old Dominion University, Norfolk, Virginia 23529 0136, USA
    J Int Neuropsychol Soc 12:867-82. 2006
    ..gesture knowledge suggest that verb retrieval may be particularly amenable to gesture+verbal training (GVT) in aphasia compared to noun retrieval...
  79. doi Predictors of emotional distress after stroke
    Shirley A Thomas
    Division of Rehabilitation and Ageing, University of Nottingham, B Floor Medical School, Queens Medical Centre, Nottingham NG7 2UH, UK
    Stroke 39:1240-5. 2008
    The aim of this prospective longitudinal study was to identify factors relating to emotional distress in the first 6 months after stroke in a sample including patients with aphasia.
  80. ncbi An investigation of sensory deficits underlying the aphasia-like behavior of macaques with auditory cortex lesions
    I A Harrington
    Laboratory of Comparative Hearing, Department of Psychology, University of Toledo, Toledo, OH 43606, USA
    Neuroreport 12:1217-21. 2001
    Bilateral auditory cortex lesions in Japanese macaques result in an aphasia-like deficit in which the animals are unable to discriminate two forms of their coo vocalizations...
  81. pmc Apraxia in progressive nonfluent aphasia
    Jonathan Daniel Rohrer
    Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Neurol 257:569-74. 2010
    ..Here we addressed this issue in progressive nonfluent aphasia (PNFA), a canonical subtype of frontotemporal lobar degeneration that has been consistently associated with ..
  82. ncbi A randomized, placebo-controlled study of donepezil in poststroke aphasia
    M L Berthier
    Centro de Investigaciones Médico Sanitarias, University of Malaga School of Medicine, Spain
    Neurology 67:1687-9. 2006
    ..placebo-controlled, double-blind parallel trial to evaluate the efficacy and safety of donepezil in chronic poststroke aphasia. Donepezil (10 mg/day) improved aphasia severity at endpoint (week 16) relative to placebo (p = 0.037).
  83. doi Exploring multimodal semantic control impairments in semantic aphasia: evidence from naturalistic object use
    Faye Corbett
    School of Psychological Sciences, University of Manchester, UK
    Neuropsychologia 47:2721-31. 2009
    ..studies have shown that patients with multimodal semantic impairments following stroke - referred to as semantic aphasia (SA) - show deficits on a range of conceptual tasks due to a failure of semantic control processes in the context ..
  84. ncbi Motor neurone disease, dementia and aphasia: coincidence, co-occurrence or continuum?
    T H Bak
    MRC, Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    J Neurol 248:260-70. 2001
    ..language production and comprehension were also observed by early authors, although they were rarely described as aphasia. The striking similarity to the contemporary descriptions is, however, sometimes obscured by diverging ..
  85. ncbi Variability in language recovery after first-time stroke
    R M Lazar
    Department of Neurology, Columbia University College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    J Neurol Neurosurg Psychiatry 79:530-4. 2008
    Predicting aphasia recovery after stroke has been difficult due to substantial variability in outcomes. Few studies have characterised the nature and extent of recovery, beginning with baselines at 24-72 hours after stroke onset.
  86. pmc Progressive aphasia secondary to Alzheimer disease vs FTLD pathology
    K A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 70:25-34. 2008
    The pathology causing progressive aphasia is typically a variant of frontotemporal lobar degeneration, especially with ubiquitin-positive inclusions (FTLD-U). Less commonly the underlying pathology is Alzheimer disease (AD).
  87. doi The problem of aphasia in the assessment of consciousness in brain-damaged patients
    Steve Majerus
    Center for Cognitive and Behavioral Neuroscience and Coma Science Group, University of Liege, Belgium
    Prog Brain Res 177:49-61. 2009
    ..with such disorders of consciousness have underlying deficits in the domain of communication functions, such as aphasia. The present paper examines the consequences of receptive and/or productive aphasia on the already limited ..
  88. ncbi Role of the right and left hemispheres in recovery of function during treatment of intention in aphasia
    Bruce Crosson
    Malcom Randall Veterans Affairs Medical Center, Gainesville, FL, USA
    J Cogn Neurosci 17:392-406. 2005
    Two patients with residual nonfluent aphasia after ischemic stroke received an intention treatment that was designed to shift intention and language production mechanisms from the frontal lobe of the damaged left hemisphere to the right ..
  89. pmc Hemodynamic response function in patients with stroke-induced aphasia: implications for fMRI data analysis
    B Bonakdarpour
    Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208, USA
    Neuroimage 36:322-31. 2007
    ..The present study examined the HRF and SNR in five individuals with aphasia resulting from stroke and four unimpaired participants using a lexical decision task and a long trial event-..
  90. doi An fMRI study showing the effect of acupuncture in chronic stage stroke patients with aphasia
    Anson C M Chau
    Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Acupunct Meridian Stud 3:53-7. 2010
    Acupuncture is used as a treatment in stroke patients with aphasia, yet the underlying neural mechanisms are unknown...
  91. ncbi Long-term stability of improved language functions in chronic aphasia after constraint-induced aphasia therapy
    Marcus Meinzer
    Department of Psychology, University of Konstanz, Konstanz, Germany
    Stroke 36:1462-6. 2005
    In response to the established notion that improvement of language functions in chronic aphasia only can be achieved through long-term treatment, we examined the efficacy of a short-term, intensive language training, constraint-induced ..
  92. ncbi Stroke and Aphasia Quality of Life Scale-39 (SAQOL-39): evaluation of acceptability, reliability, and validity
    Katerina Hilari
    Department of Language and Communication Science, Institute of Health, City University, Northampton Square, London EC1V 0HB, UK
    Stroke 34:1944-50. 2003
    ..scales (eg, SS-QOL, SIS) have generally been developed with samples of stroke survivors that exclude people with aphasia. We adapted the SS-QOL for use with people with aphasia to produce the Stroke and Aphasia Quality of Life Scale (..
  93. doi Dissociation between singing and speaking in expressive aphasia: the role of song familiarity
    Thomas Straube
    Department of Biological and Clinical Psychology, Friedrich Schiller University of Jena, Am Steiger 3 1, D 07743 Jena, Germany
    Neuropsychologia 46:1505-12. 2008
    ..investigated the role of singing during repetition of word phrases in a patient severely affected with non-fluent aphasia (GS) who had an almost complete lesion of the left hemisphere...
  94. ncbi Poststroke aphasia : epidemiology, pathophysiology and treatment
    Marcelo L Berthier
    Centro de Investigaciones Médico Sanitarias CIMES, Departamento de Medicina, Universidad de Malaga, Campus Universitario Teatinos, University of Malaga, Malaga, Spain
    Drugs Aging 22:163-82. 2005
    b>Aphasia, the loss or impairment of language caused by brain damage, is one of the most devastating cognitive impairments of stroke...
  95. doi Short-term anomia training and electrical brain stimulation
    Agnes Floel
    Charite Universitatsmedizin, Department of Neurology, Center for Stroke Research Berlin and Cluster of Excellence NeuroCure, Chariteplatz 1, 10117 Berlin, Germany
    Stroke 42:2065-7. 2011
    Language training success in chronic aphasia remains only moderate. Electric brain stimulation may be a viable way to enhance treatment efficacy.
  96. ncbi Overt naming in aphasia studied with a functional MRI hemodynamic delay design
    Paula I Martin
    Harold Goodglass Boston University Aphasia Research Center, Department of Neurology, Boston University School of Medicine, MA 02130, USA
    Neuroimage 28:194-204. 2005
    The purpose of this study was to develop a functional MRI method to examine overt speech in stroke patients with aphasia. An fMRI block design for overt picture naming was utilized which took advantage of the hemodynamic response delay ..
  97. ncbi A study of syntactic processing in aphasia II: neurological aspects
    David Caplan
    Neuropsychology Laboratory, Massachusetts General Hospital, Boston, MA 02114, USA
    Brain Lang 101:151-77. 2007
    ..We studied 42 patients with aphasia secondary to left hemisphere strokes and 25 control subjects for the ability to assign and interpret three ..
  98. doi Time course of evoked-potential changes in different forms of anomia in aphasia
    Marina Laganaro
    Geneva University Hospital and University of Geneva, Switzerland
    J Cogn Neurosci 21:1499-510. 2009
    ..Moreover, the findings give support to current hypotheses on the time course of processes involved in word production during picture naming...
  99. ncbi Dynamics of language reorganization after stroke
    Dorothee Saur
    Department of Neurology, University Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Brain 129:1371-84. 2006
    Previous functional imaging studies of chronic stroke patients with aphasia suggest that recovery of language occurs in a pre-existing, bilateral network with an upregulation of undamaged areas and a recruitment of perilesional tissue ..
  100. pmc Predicting language improvement in acute stroke patients presenting with aphasia: a multivariate logistic model using location-weighted atlas-based analysis of admission CT perfusion scans
    S Payabvash
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114 9657, USA
    AJNR Am J Neuroradiol 31:1661-8. 2010
    ..Our purpose was to construct a more focused, location-weighted multivariate model for the prediction of early aphasia improvement, based not only on traditional clinical and imaging parameters, but also on atlas-based structure/..
  101. pmc Changes in white matter integrity follow excitatory rTMS treatment of post-stroke aphasia
    Jane B Allendorfer
    Department of Neurology, University of Cincinnati Academic Health Center, Cincinnati, OH, USA
    Restor Neurol Neurosci 30:103-13. 2012
    ....

Research Grants79

  1. Katherine P Rankin; Fiscal Year: 2016
    ..50 frontotemporal dementia, 50 cerebrovascular disease, 25 semantic dementia, 25 progressive nonfluent aphasia, 25 dementia with Lewy-bodies, 25 progressive supranuclear palsy, and 25 corticobasal degeneration), as well as ..
  2. Neural substrates for matching hearing to utterance
    Darcy B Kelley; Fiscal Year: 2012
    ..Articulation disorders, which are commonly regarded as motor in origin, such a stuttering and aphasia, can improve, sometimes quite dramatically, by auditory cues delivered in a social context such as choral ..
  3. Margaret A Naeser; Fiscal Year: 2016
    ..after a series of red/NIR LED treatments in chronic stroke;and neurodegenerative disease, Primary Progressive Aphasia (similar to Alzheimer's Disease)...
  4. Shannon C Mauszycki; Fiscal Year: 2016
    ..disorders, but AOS tends to occurs more frequently as a secondary communication disorder in conjunction with aphasia (Duffy, 2007)...
  5. David L Sheinberg; Fiscal Year: 2016
    ..with patients suffering from diseases of the nervous system including those with Obsessive Compulsive Disorder, Aphasia, Parkinson's Disease, and Addiction. On average, students in our program finish their PhD in 5...
  6. Toward a multi-modal and multi-level analysis of Chinese aphasic discourse
    PAK HIN ANTHONY KONG; Fiscal Year: 2013
    ..applicant): The current project proposes to construct a corpus of discourse production of Chinese speakers with aphasia, one of the underrepresented minority groups as listed by the National Institutes of Health (NIH)...
  7. Speech Perception Assessment and Training System for Aphasia Rehabilitation
    James D Miller; Fiscal Year: 2010
    ..test the feasibility of a computerized speech perception assessment and training system (SPATS-AR) as a novel aphasia rehabilitation option...
  8. Functional Architecture of Human Speech Motor Cortex
    Edward Chang; Fiscal Year: 2011
    ..for understanding a large number of communication disorders including mutism, stuttering, apraxia of speech, and aphasia. In addition, the proposed research seeks to translate critical knowledge on the neural control of speech to ..
  9. JENNIFER LOUISE WHITWELL; Fiscal Year: 2016
    ..of a language disorder whereby patients have problems with grammar and spoken language, known as non-fluent aphasia (NFA)...
  10. Promoting Functional Communication Abilities in Aphasia with Virtual Reality
    Nadine Martin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aphasia is an acquired communication disorder that affects the ability to speak and understand spoken language, reading, and writing...
  11. EMILY J ROGALSKI; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Primary progressive aphasia (PPA) is a clinical dementia syndrome caused by neurodegenerative brain disease, with language impairment as the primary feature...
  12. Remediation of Word Processing and Short-Term Memory Deficits in Aphasia
    Nadine Martin; Fiscal Year: 2009
    ..One focus of research in aphasia therapy has been to understand how the content of treatment interacts with impaired word representations (..
  13. A Unified Neuroanatomical Model of Speech Production and Perception: Implications
    Christopher Rorden; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Apraxia of speech (AOS) and conduction aphasia are commonly caused by left hemisphere stroke and often severely affect speech production...
  14. Igor J Koralnik; Fiscal Year: 2016
    ..This patient presented with lesions restricted to the hemispheric gray matter on MRI, developed aphasia, progressive cognitive dysfunction and seizures and had a rapid fatal outcome...
  15. Gregory Hickok; Fiscal Year: 2015
    ..To speed the pace of lesion work, which can be laboriously slow, we have developed a Multisite Aphasia Research Consortium (MARC) that will enable us to collect data at an unprecedented pace...
  16. Structure of Semantic Memory and its Measurement in Dementia and Aphasia
    JAMES JOSEPH REILLY; Fiscal Year: 2013
    ..Components of this battery will include knowledge: a) word meaning;b) perceptual features;c) abstract attributes;d) environmental context;e) associative relationships;and f) object function. ..
  17. SUZEE EURIE LEE; Fiscal Year: 2015
    ..Maria-Luisa Gorno-Tempini, a neurologist who focuses on neuroimaging in primary progressive aphasia and Dr. John Neuhaus, a statistician, who is an expert in study design and biostatistical analysis...
  18. MARIA LUISA GORNO TEMPINI; Fiscal Year: 2016
    ..speech and language deficits remain isolated for the initial phases of the disease, the term "primary progressive aphasia" (PPA) applies...
  19. Functional neuroimaging of language processing in primary progressive aphasia
    Stephen M Wilson; Fiscal Year: 2012
    Primary progressive aphasia (PPA) is a clinical syndrome in which degeneration of language regions in the dominant hemisphere is associated with progressive deficits in speech and/or language function...
  20. BRIAN PASLEY; Fiscal Year: 2014
    ..and language function is a fundamental challenge for clinical insights into communication disorders such as aphasia or dyslexia...
  21. MAREK MARSEL M MESULAM; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Primary progressive aphasia (PPA) is a brain disease that causes a gradual and increasingly more debilitating impairment of word usage and comprehension...
  22. Amyloid PET in AD, FTLD &PPA: Diagnosis, Functional &Structural Correlations
    GIL DAN RABINOVICI; Fiscal Year: 2012
    ..Primary progressive aphasia (PPA) is a clinical syndrome that can be caused by FTLD or (less commonly) AD pathology...
  23. Sarel van Vuuren; Fiscal Year: 2015
    ..Few studies have systematically investigated the effects of theory-driven variables that are inherent to the aphasia treatment process, regardless of the specific treatment approach...
  24. Primary Progressive Aphasia: Neural Bases and Rehabilitation
    MAYA HENRY; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Primary progressive aphasia (PPA) is a gradual decline in language skills that results from neurodegenerative disease affecting language cortex...
  25. Eyetracking Comprehension Assessment System (ECAS): Improving Validity of Compreh
    Brooke Hallowell; Fiscal Year: 2010
    ..of ECAS methods through experimentation with (a) adults without any neurological disorder and (b) adults with aphasia due to cerebrovascular accident (stroke);(8) establish normative data for two standardized tests of auditory ..
  26. The Role of Cognitive Coherence in Reference Resolution
    ELSI M KAISER; Fiscal Year: 2012
    ..g., individuals with aphasia or Alzheimer's disease)...
  27. Cynthia K Thompson; Fiscal Year: 2016
    ..is focused on providing a neuroimaging-based examination of language recovery in individuals with chronic aphasia resulting from stroke...
  28. Identifying the Vocal Markers of Schizophrenia-Spectrum Disorders
    Alex Cohen; Fiscal Year: 2012
    ..It is hoped that insights from this project will lead to the development of automated assessments that can be applied to both clinical and research settings as a cost-effective and highly sensitive assessment of key symptoms. ..
  29. Jacquie Kurland; Fiscal Year: 2016
    ..provided by applicant): Despite recent evidence demonstrating treatment-induced neuroplasticity in chronic aphasia, questions remain regarding the influence of treatment variables on language recovery, the neural mechanisms ..
  30. Bioinformatics Infrastructure for Large Scale Studies of Aphasia Recovery
    Steven L Small; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Large prospective studies of aphasia recovery that incorporate anatomical, physiological, and behavioral data are virtually non-existent...
  31. Brian MacWhinney; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Aphasia Bank is a shared database of multimedia interactions for the study of communication in aphasia. The goal of this work is the improvement of patient- oriented treatment of aphasia...
  32. Neocortical Mechanisms of Categorical Speech Perception
    Edward Chang; Fiscal Year: 2009
    ..g. aphasia, dyslexia, autism, et alia)...
  33. Transcranial Direct Current Stimulation and Aphasia Language Therapy
    Leora R Cherney; Fiscal Year: 2010
    ..preliminary data about its efficacy under different polarity conditions in individuals with chronic nonfluent aphasia. Facilitating brain plasticity with the direct application of stimulation to the cerebral cortex has been studied ..
  34. MICHAEL KEHAS TANENHAUS; Fiscal Year: 2015
    ..S. with some form of aphasia)...
  35. Marlis Gonzalez-Fernandez; Fiscal Year: 2016
    ..distinct neuro-anatomical locations;and 2) To identify associations and dissociations between specific types of aphasia, types of motor speech deficits (dysarthrias and apraxia of speech), and affected swallowing stages (oral, ..
  36. MAREK MARSEL M MESULAM; Fiscal Year: 2016
    ..C) Serve a leadership role in FTLD neuropathology and primary progressive aphasia (PPA) in keeping with the unique strengths of the Northwestern ADC in this area of dementia research...
  37. Changes in Neural Patterns in Persons with Aphasia Following Theory-based Generat
    CHALEECE WYATT SANDBERG; Fiscal Year: 2013
    ..Although many treatment paradigms exist for aphasia rehabilitation with behaviorally successful outcomes, it is still unclear what specific positive ..
  38. Diane L Kendall; Fiscal Year: 2014
    ..g. sound) based treatment program for word retrieval deficits in aphasia. The most common feature of aphasia is impairment in ability to name objects...
  39. Improving Outcomes for Mechanically Ventilated Patients with the Digital EZ Board
    MARY E HAPP; Fiscal Year: 2013
    ..However, patients with special communication handicaps [e.g., limited English proficiency, hearing impairment, aphasia, intubation for mechanical ventilation (MV)] have a limited number of tools to help them communicate their needs ..
  40. Theoretically based treatment for sentence comprehension deficits in aphasia
    Swathi Kiran; Fiscal Year: 2013
    ..Diagnosis and treatment of sentence comprehension deficits in patients with aphasia is one area where disparities continue to exist even though this topic is of great theoretical importance...
  41. Behavioral and Neural Correlates of Melodic Intonation Therapy
    Gottfried Schlaug; Fiscal Year: 2012
    One of the few accepted treatments for severe non-fluent aphasia is Melodic Intonation Therapy (MIT)...
  42. Sheila E Blumstein; Fiscal Year: 2014
    ..recent findings indicating spared properties of the functional architecture of spoken word production in aphasia. Five nonfluent aphasics who have speech output deficits, and five fluent aphasics who produce phonemic ..
  43. Jerzy P Szaflarski; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Aphasia after stroke is associated with high mortality, significant motor impairment, and severe limitations in social participation...
  44. Boston University Aphasia Research Core Center
    Martin L Albert; Fiscal Year: 2012
    The unifying agenda of the Harold Goodglass Aphasia Research Center (HGARC) is to integrate research and researchers to arrive at a coherent picture of how language is represented in the brain for the purpose of diagnosis and treatment ..
  45. Neuroimaging of Metaphor Processing
    Michele T Diaz; Fiscal Year: 2010
    ..Even when brain injuries do not result in aphasia, figurative language processing can be impaired...
  46. David P Corina; Fiscal Year: 2016
    ..the mirror system has been implicated in a range of acquired and developmental disorders ranging from apraxia and aphasia to autism...
  47. Thomas Hatsukami; Fiscal Year: 2015
    ..65 years of age and older, 50% have some hemiparesis, 30% are unable to walk without assistance, 19% have aphasia, and 26% are institutionalized in a nursing home six months following their ischemic event...
  48. Learning Beyond Criterion in Aphasia Rehabilitation
    Rhonda Friedman; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Acquired reading disorders (alexias) are common in patients with aphasia subsequent to left hemisphere stroke or head injury...
  49. Indices of Lexical Access During Idiom Comprehension
    Kathleen Brumm; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This project examines spoken language comprehension in individuals with aphasia, a language disorder acquired subsequent to stroke...
  50. PELAGIE M BEESON; Fiscal Year: 2015
    ..This question is central to the focus of every clinician and clinical researcher working with adults with aphasia, alexia, and agraphia...
  51. DAVID E POEPPEL; Fiscal Year: 2016
    ..Health-related phenomena ranging from dyslexia and autism in childhood to aphasia and Alzheimer's disease in the aging population have been repeatedly linked to problems with the auditory ..
  52. Edward Chang; Fiscal Year: 2016
    ..underlie the pathogenesis of an increasing number of acquired and developmental language disabilities, including aphasia, language learning delay, autism, and dyslexia...
  53. GAYLE L DEDE; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): More than one million Americans have aphasia, and most of them experience some difficulty with sentence comprehension...
  54. Julia Schuchard; Fiscal Year: 2014
    ..procedures have the potential to greatly enhance language training, and yet have received little attention in the aphasia rehabilitation literature...
  55. fMRI of Language Recover Following Stroke in Adults
    Jerzy P Szaflarski; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Aphasia after stroke is associated with high mortality and severe motor, social, and cognitive disability...
  56. Julius Fridriksson; Fiscal Year: 2016
    ..One of the most devastating impairments resulting from stroke is aphasia, a language impairment caused by left hemisphere damage involving cortical language areas...
  57. Argye E Hillis; Fiscal Year: 2016
    ..model of recovery will serve in the future as the basis for targeted brain-based interventions for aphasia, which require an understanding of the anatomy of language networks, as well as the extent and timing of how ..
  58. Nina F Dronkers; Fiscal Year: 2014
    ..This will be done through extensive evaluation of 60 chronic brain-injured patients with aphasia due to stroke, whose language and neuropsychological deficits will be thoroughly evaluated by our staff at the ..
  59. TARGETED TRANSCRANIAL ELECTROTHERAPY SYSTEM TO ACCELERATE STROKE RECOVERY
    Lucas C Parra; Fiscal Year: 2012
    ..The efficacy of the technique will be demonstrated on improved language training in stroke patients with aphasia. Milestones for a successful Phase-1 are: 1...
  60. Effects of Argument Structure &Processing Load on Sentence Processing in Aphasia
    Nadine Martin; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Acquired aphasia is a lifelong disability that affects functional communication and consequently, quality of life...
  61. WILLIAM STREICHER EVANS; Fiscal Year: 2014
    ..this project is to improve our understanding of the cognitive-communication deficits experienced by persons with aphasia (PWA)...
  62. Miguel A L Nicolelis; Fiscal Year: 2015
    ..Disorders of temporal processing have been linked to neurological diseases, such as aphasia, dyslexia and Parkinson's disease...
  63. Theoretically based treatment for sentence comprehension deficits in aphasia
    Swathi Kiran; Fiscal Year: 2009
    ..Diagnosis and treatment of sentence comprehension deficits in patients with aphasia is one area where disparities continue to exist even though this topic is of great theoretical importance...
  64. EYE MOVEMENTS AND LINGUISTIC COMPREHENSION IN APHASIA
    Brooke Hallowell; Fiscal Year: 2002
    ..A majority of patients who present with aphasia also present with motoric and/or perceptual deficits that may impair their ability to respond, or to respond ..
  65. Analysis and Remediation of Language Production
    RITA BERNDT; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Aphasia strikes approximately one in 250 Americans...
  66. Brain Organization: Clues from Sign Aphasia
    Ursula Bellugi; Fiscal Year: 2006
    ..abstract_text> ..
  67. Computer mediated speech assessment in aphasia and AOS
    Katarina Haley; Fiscal Year: 2006
    ..Few tools are available for objective and sensitive quantification of speech involvement in persons with aphasia and other language disorders...
  68. Functional MRI of Recovery in Fluent Aphasia
    JEFFREY BINDER; Fiscal Year: 2007
    ..provided by applicant): This project examines specific brain mechanisms underlying recovery of fluent aphasia in left hemisphere stroke patients...
  69. Neurophysiological Measurement in Aphasia Treatment
    Steven Small; Fiscal Year: 2009
    ..diffusion tensor imaging (DTI) can be helpful in characterizing the neurophysiological status of patients with aphasia. Such measurements can be used to develop treatment approaches, select patient-specific treatments, and gauge the ..
  70. Neurophysiological Effects of Amphetamine Aphasia
    Gerry Stefanatos; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Neuropharmacological studies of acquired aphasia have suggested that the outcome of speech/language therapy, the primary form of rehabilitation for aphasia, can be enhanced by adjuvant ..
  71. DIAGNOSIS AND TREATMENT OF READING DEFICITS IN APHASIA
    Margaret Greenwald; Fiscal Year: 2001
    ..The diagnostic and treatment methods advanced here are intended as a model to guide further development and implementation of more effective treatments for language disorders, particularly acquired dyslexia. ..