language disorders

Summary

Summary: Conditions characterized by deficiencies of comprehension or expression of written and spoken forms of language. These include acquired and developmental disorders.

Top Publications

  1. ncbi Developmental dyslexia and specific language impairment: same or different?
    Dorothy V M Bishop
    Department of Experimental Psychology, Oxford University, Oxford, United Kingdom
    Psychol Bull 130:858-86. 2004
  2. pmc Genetic advances in the study of speech and language disorders
    D F Newbury
    Wellcome Trust Centre for Human Genetics, Headington, Oxford, UK
    Neuron 68:309-20. 2010
  3. pmc Are specific language impairment and dyslexia distinct disorders?
    Hugh W Catts
    Department of Speech Language Hearing, University of Kansas, Lawrence 66045, USA
    J Speech Lang Hear Res 48:1378-96. 2005
  4. ncbi A forkhead-domain gene is mutated in a severe speech and language disorder
    C S Lai
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 413:519-23. 2001
  5. ncbi Decoding the genetics of speech and language
    Sarah A Graham
    Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands
    Curr Opin Neurobiol 23:43-51. 2013
  6. ncbi Genetic and environmental influence on language impairment in 4-year-old same-sex and opposite-sex twins
    Essi Viding
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 45:315-25. 2004
  7. ncbi A longitudinal investigation of early reading and language skills in children with poor reading comprehension
    Kate Nation
    Department of Experimental Psychology, University of Oxford, UK
    J Child Psychol Psychiatry 51:1031-9. 2010
  8. ncbi Precursors to speech in infancy: the prediction of speech and language disorders
    D K Oller
    Dept of Communication Sciences and Disorders, University of Maine, Orono 04469, USA
    J Commun Disord 32:223-45. 1999
  9. ncbi Prevalence of specific language impairment in kindergarten children
    J B Tomblin
    University of Iowa, Iowa City, USA
    J Speech Lang Hear Res 40:1245-60. 1997
  10. ncbi Language-association cortex asymmetry in autism and specific language impairment
    Lies De Fossé
    Center for Morphometric Analysis, Massachusetts General Hospital
    Ann Neurol 56:757-66. 2004

Detail Information

Publications232 found, 100 shown here

  1. ncbi Developmental dyslexia and specific language impairment: same or different?
    Dorothy V M Bishop
    Department of Experimental Psychology, Oxford University, Oxford, United Kingdom
    Psychol Bull 130:858-86. 2004
    ....
  2. pmc Genetic advances in the study of speech and language disorders
    D F Newbury
    Wellcome Trust Centre for Human Genetics, Headington, Oxford, UK
    Neuron 68:309-20. 2010
    Developmental speech and language disorders cover a wide range of childhood conditions with overlapping but heterogeneous phenotypes and underlying etiologies...
  3. pmc Are specific language impairment and dyslexia distinct disorders?
    Hugh W Catts
    Department of Speech Language Hearing, University of Kansas, Lawrence 66045, USA
    J Speech Lang Hear Res 48:1378-96. 2005
    ..The purpose of this study was to determine whether specific language impairment (SLI) and dyslexia are distinct developmental disorders...
  4. ncbi A forkhead-domain gene is mutated in a severe speech and language disorder
    C S Lai
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 413:519-23. 2001
    ..Our findings suggest that FOXP2 is involved in the developmental process that culminates in speech and language...
  5. ncbi Decoding the genetics of speech and language
    Sarah A Graham
    Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands
    Curr Opin Neurobiol 23:43-51. 2013
    ..Initial clues come from identification of genetic risk factors implicated in developmental language disorders. The underlying genetic architecture is complex, involving a range of molecular mechanisms...
  6. ncbi Genetic and environmental influence on language impairment in 4-year-old same-sex and opposite-sex twins
    Essi Viding
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 45:315-25. 2004
    ..We investigated the aetiology of language impairment in 579 four-year-old twins with low language performance and their co-twins, members of 160 MZ twin pairs, 131 same-sex DZ pairs and 102 opposite-sex DZ pairs...
  7. ncbi A longitudinal investigation of early reading and language skills in children with poor reading comprehension
    Kate Nation
    Department of Experimental Psychology, University of Oxford, UK
    J Child Psychol Psychiatry 51:1031-9. 2010
    ..We used a longitudinal design to examine earlier reading and language skills in children identified as poor comprehenders in mid-childhood...
  8. ncbi Precursors to speech in infancy: the prediction of speech and language disorders
    D K Oller
    Dept of Communication Sciences and Disorders, University of Maine, Orono 04469, USA
    J Commun Disord 32:223-45. 1999
    ..The results suggest that late onset of canonical babbling, a factor that can be monitored effectively through an interview with a parent, can predict delay in the onset of speech production...
  9. ncbi Prevalence of specific language impairment in kindergarten children
    J B Tomblin
    University of Iowa, Iowa City, USA
    J Speech Lang Hear Res 40:1245-60. 1997
    ..Also, the clinical identification of these children remains low among kindergarteners...
  10. ncbi Language-association cortex asymmetry in autism and specific language impairment
    Lies De Fossé
    Center for Morphometric Analysis, Massachusetts General Hospital
    Ann Neurol 56:757-66. 2004
    ..Linguistically unimpaired boys with autism had similar asymmetry compared with the control group, suggesting that Broca's area asymmetry reversal is related more to language impairment than specifically to autism diagnosis...
  11. ncbi Genetic influences on language impairment and literacy problems in children: same or different?
    D V Bishop
    Dept Experimental Psychology, University of Oxford, UK
    J Child Psychol Psychiatry 42:189-98. 2001
    ..Thus the different pattern of results in the two studies can be explained if one assumes that genetic influences are substantial only when literacy problems are severe and/or accompanied by oral language difficulties...
  12. ncbi Autobiographical memory and autonoetic consciousness: triple dissociation in neurodegenerative diseases
    Pascale Piolino
    Inserm E0218 Université de Caen, CHU Cote de Nacre, 14033 Caen, France
    Brain 126:2203-19. 2003
    ....
  13. ncbi Prevalence of speech delay in 6-year-old children and comorbidity with language impairment
    L D Shriberg
    University of Wisconsin, Madison 53705, USA
    J Speech Lang Hear Res 42:1461-81. 1999
    ..Discussion includes implications of findings for speech-language phenotyping in genetics studies...
  14. pmc Heritability of specific language impairment depends on diagnostic criteria
    D V M Bishop
    Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
    Genes Brain Behav 7:365-72. 2008
    ..Childhood language disorders that are identified by population screening are likely to have a different phenotype and different etiology ..
  15. pmc Telerehabilitation, virtual therapists, and acquired neurologic speech and language disorders
    Leora R Cherney
    Center for Aphasia Research and Treatment, Rehabilitation Institute of Chicago, IL 60611, USA
    Semin Speech Lang 33:243-57. 2012
    ..This article reviews the evidence related to acquired neurologic speech and language disorders in adults, focusing on studies that have been published since 2000...
  16. pmc Overlaps between autism and language impairment: phenomimicry or shared etiology?
    D V M Bishop
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK
    Behav Genet 40:618-29. 2010
    ..The simulations further suggest that the shape of distributions of phenotypic trait scores for different genotypes may provide evidence of whether a gene is involved in epistasis...
  17. ncbi FOXP genes, neural development, speech and language disorders
    Hiroshi Takahashi
    Developmental Neurobiology Group, Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Japan
    Adv Exp Med Biol 665:117-29. 2009
    ..This assumption is supported by brain imaging data obtained by using fMRI and PET on the FOXP2-mutated patients and also by analysis of Foxp2 mutant mice...
  18. ncbi Detecting subtle spontaneous language decline in early Alzheimer's disease with a picture description task
    K E Forbes-McKay
    School of Applied Social Studies, The Robert Gordon University, Aberdeen, UK
    Neurol Sci 26:243-54. 2005
    ..Prospective assessment of spontaneous language skills with a picture description task is useful to detect those subtle spontaneous language impairments caused by AD even at an early stage of the disease...
  19. ncbi The prevalence of autistic spectrum disorders in adolescents with a history of specific language impairment (SLI)
    Gina Conti-Ramsden
    School of Psychological Sciences, University of Manchester, UK
    J Child Psychol Psychiatry 47:621-8. 2006
    ..The present study aimed to examine the prevalence of autism spectrum disorders in a large sample of adolescents with a history of SLI...
  20. pmc DCDC2, KIAA0319 and CMIP are associated with reading-related traits
    Tom S Scerri
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Biol Psychiatry 70:237-45. 2011
    ..Several susceptibility genes have been proposed for dyslexia (reading disability; RD) and specific language impairment (SLI). RD and SLI show comorbidity, but it is unclear whether a common genetic component is shared...
  21. ncbi Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's disease
    Mark W Bondi
    Psychology Service, Veterans Affairs San Diego Healthcare System and Department of Psychiatry, University of California 92161, USA
    Neuropsychology 16:335-43. 2002
    ..Results of clinicopathologic correlations in an autopsy-confirmed AD subgroup further suggest the invocation of a broad network of integrated cortical regions and executive and language processes underlying successful SCWT performance...
  22. ncbi Nonword repetition performance in school-age children with and without language impairment
    S Ellis Weismer
    University of Wisconsin Madison, 53706, USA
    J Speech Lang Hear Res 43:865-78. 2000
    ..Results from likelihood ratio analyses indicated that NRT performance, though not sufficient on its own, may provide a useful index to assist in ruling in or ruling out language disorder...
  23. ncbi Language in autism and specific language impairment: where are the links?
    David Williams
    Institute of Child Health, University College London, London, United Kingdom
    Psychol Bull 134:944-63. 2008
    ..They recommend that researchers concentrate on those aspects of language impairment that predominate in each disorder rather than on those comparatively small areas of potential overlap...
  24. ncbi Practitioner review: short-term and working memory impairments in neurodevelopmental disorders: diagnosis and remedial support
    Susan E Gathercole
    Department of Psychology, University of Durham, UK
    J Child Psychol Psychiatry 47:4-15. 2006
    ..The memory impairments associated with a range of neurodevelopmental disorders (Down's syndrome, Williams syndrome, Specific Language Impairment, and attentional deficits) are discussed...
  25. ncbi Characteristics of children attending language units in England: a national study of 7-year-olds
    G Conti-Ramsden
    Centre for the Study of Language Impairments, University of Manchester, UK
    Int J Lang Commun Disord 34:359-66. 1999
    ..attending language units fit the discrepancy criteria between verbal and non-verbal ability diagnostic of specific language impairment (SLI)?; and what types of language difficulties do children with SLI attending language units have?..
  26. pmc Genetic and environmental risks for specific language impairment in children
    D V Bishop
    Oxford Study of Children s Communication Impairments, Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK
    Philos Trans R Soc Lond B Biol Sci 356:369-80. 2001
    ..Research is reviewed that suggests that may not be a fruitful approach to SLI, and that an approach in terms of multiple risk and protective factors, which is widely adopted in medicine, is more realistic...
  27. ncbi Use of preoperative functional neuroimaging to predict language deficits from epilepsy surgery
    D S Sabsevitz
    Department of Neurology and the Comprehensive Epilepsy Center, Medical College of Wisconsin, Milwaukee 53226, USA
    Neurology 60:1788-92. 2003
    ..Left anterior temporal lobectomy (L-ATL) may be complicated by confrontation naming deficits...
  28. ncbi Schizophrenia and the structure of language: the linguist's view
    Michael A Covington
    Artificial Intelligence Center, The University of Georgia, 111 Boyd GSRC, Athens, GA 30602 7415, USA
    Schizophr Res 77:85-98. 2005
    ..Clanging (glossomania) is straightforwardly explainable as distraction by self-monitoring. Recent research has begun to relate schizophrenia, which is partly genetic, to the genetic endowment that makes human language possible...
  29. pmc Deployment and validation of a smart system for screening of language disorders in primary care
    María Luisa Martín-Ruiz
    Departamento de Ingeniería y Arquitecturas Telemáticas, Universidad Politecnica de Madrid, Carretera de Valencia km 7, Madrid 28031, Spain
    Sensors (Basel) 13:7522-45. 2013
    ..research paper focuses on the deployment and evaluation of a smart system that enhances the screening of language disorders in primary care. Pediatricians get support to proceed with early referral of language disorders...
  30. pmc On the tip-of-the-tongue: neural correlates of increased word-finding failures in normal aging
    Meredith A Shafto
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    J Cogn Neurosci 19:2060-70. 2007
    ....
  31. pmc CMIP and ATP2C2 modulate phonological short-term memory in language impairment
    Dianne F Newbury
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Am J Hum Genet 85:264-72. 2009
    ..This work therefore implicates CMIP and ATP2C2 in the etiology of SLI and provides molecular evidence for the importance of phonological short-term memory in language acquisition...
  32. ncbi Why do Alzheimer patients have difficulty with pronouns? Working memory, semantics, and reference in comprehension and production in Alzheimer's disease
    A Almor
    Hedco Neuroscience Building, University of Southern California, Los Angeles 90089 2520, USA
    Brain Lang 67:202-27. 1999
    ....
  33. ncbi Learning and memory performance of children with specific language impairment (SLI)
    Cynthia A Riccio
    Texas A and M University, College Station, Texas 77845 4225, USA
    Appl Neuropsychol 14:255-61. 2007
    ..These results provide support for the contention that children with SLI have a "diminished verbal capacity" to process, organize, and maintain auditory information in working memory...
  34. ncbi Phonological processing, language, and literacy: a comparison of children with mild-to-moderate sensorineural hearing loss and those with specific language impairment
    J Briscoe
    Oxford Study of Children s Communication Impairments, University of Oxford, UK
    J Child Psychol Psychiatry 42:329-40. 2001
    ..Implications for theories of SLI are discussed...
  35. pmc Children's history of speech-language difficulties: genetic influences and associations with reading-related measures
    Laura Segebart DeThorne
    Department of Speech and Hearing Science, University of Illinois at Urbana Champaign, IL 61820, USA
    J Speech Lang Hear Res 49:1280-93. 2006
    ....
  36. ncbi Assessing acquired language disorders in adults via the Internet
    Deborah Theodoros
    Division of Speech Pathology, School of Health and Rehabilitation Sciences, University of Queensland, Brisbane, Australia
    Telemed J E Health 14:552-9. 2008
    ....
  37. ncbi Genetics of speech and language disorders
    Changsoo Kang
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Genomics Hum Genet 12:145-64. 2011
    ..Although only a small fraction of all cases of speech and language disorders can be explained by genetic findings to date, the significant progress made thus far suggests that genetic ..
  38. ncbi Language disorders as a window on universal grammar: an abstract theory of agreement for IP, DP, and V-PP
    T Roeper
    Dept of Linguistics, University of Massachusetts, South College, Amherst, MA 01003, USA
    Brain Lang 77:378-97. 2001
    ..A case study from language disorders supports and extends this abstract concept...
  39. ncbi Nonlinguistic perceptual deficits associated with reading and language disorders
    B A Wright
    Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208, USA
    Curr Opin Neurobiol 10:482-6. 2000
    Recent behavioral evidence supports the idea that some individuals with reading and language disorders are impaired in their perception of nonlinguistic auditory and visual information...
  40. ncbi Familial aggregation in specific language impairment
    P Tallal
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark 07102, USA
    J Speech Lang Hear Res 44:1172-82. 2001
    ..impairment (SLI) and matched controls were assessed, was used to investigate familial aggregation for language disorders. Current test data from each family member showed the rate of language impairment for mothers, fathers, ..
  41. ncbi Specific language impairment is not specific to language: the procedural deficit hypothesis
    Michael T Ullman
    Department of Neuroscience, Georgetown University, Washington, DC 20057 1664, USA
    Cortex 41:399-433. 2005
    ..Finally, broader implications are discussed, and predictions for future research are presented. It is argued that the PDH forms the basis of a novel and potentially productive perspective on SLI...
  42. pmc N400 responses of children with primary language disorder: intervention effects
    Mihai Popescu
    Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas 66103, USA
    Neuroreport 20:1104-8. 2009
    ..These characteristic changes in brain responses may reflect a positive effect of the language intervention on the lexical-semantic processing skills in children with language impairment...
  43. ncbi Language disorders subsequent to left cerebellar lesions: a case for bilateral cerebellar involvement in language?
    Bruce E Murdoch
    Motor Speech and Neurogenic Language Disorders Research Centre, The University of Queensland, Brisbane, Australia
    Folia Phoniatr Logop 59:184-9. 2007
    ....
  44. ncbi Communicative competence in parents of children with autism and parents of children with specific language impairment
    Tilla F Ruser
    Department of Psychiatry, Tufts New England Medical Center, Boston, MA, USA
    J Autism Dev Disord 37:1323-36. 2007
    ..Fifteen percent of the autism and SLI parents showed severe deficits. Our results suggest that impaired communication is part of the broader autism phenotype and a broader SLI phenotype, especially among male family members...
  45. pmc Development of oral reading fluency in children with speech or language impairments: a growth curve analysis
    Cynthia S Puranik
    Florida Center for Reading Research, Florida State University, Tallahassee 32301, USA
    J Learn Disabil 41:545-60. 2008
    ..The results underscore the need to identify, monitor, and address reading fluency difficulties early among students with SI or LI...
  46. ncbi Group intervention changes brain activity in bilingual language-impaired children
    Elina Pihko
    BioMag Laboratory, Helsinki University Central Hospital, Helsinki, Finland
    Cereb Cortex 17:849-58. 2007
    ..Our results show that, in children with SLI, the positive intervention effect is reflected in plastic changes in the brain activity of the left and right auditory cortices...
  47. ncbi Look who's talking: a prospective study of familial transmission of language impairments
    R V Spitz
    Center for Molecular and Behavior Neuroscience, Rutgers University, Newark, NJ, USA
    J Speech Lang Hear Res 40:990-1001. 1997
    ..These results indicate that children with a positive family history for language impairments are at risk for language delay; the results also support a familial component to language impairments...
  48. pmc Age-related impairment of ultrasonic vocalization in Tau.P301L mice: possible implication for progressive language disorders
    Clement Menuet
    Maturation, Plasticity, Physiology and Pathology of Respiration, Unité Mixte de Recherche 6231, Centre National de la Recherche Scientifique, Universite de la Mediterranee, Universite Paul Cezanne, Marseille, France
    PLoS ONE 6:e25770. 2011
    ..diseases in elderly people and cause various cognitive, behavioural and motor defects, but also progressive language disorders. For communication and social interactions, mice produce ultrasonic vocalization (USV) via expiratory ..
  49. ncbi A longitudinal investigation of reading outcomes in children with language impairments
    Hugh W Catts
    Department of Speech Language Hearing, University of Kansas, Lawrence 66045, USA
    J Speech Lang Hear Res 45:1142-57. 2002
    ..Also, children's literacy knowledge/ experience in kindergarten and their initial reading achievement in second grade were good predictors of subsequent reading outcomes...
  50. pmc Pleiotropic effects of a chromosome 3 locus on speech-sound disorder and reading
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Rammelkamp Center for Research, Case Western Reserve University, Cleveland, OH 44109, USA
    Am J Hum Genet 74:283-97. 2004
    ..9 cM and is bounded by markers D3S3049 and D3S3045. Our results suggest that domains common to SSD and dyslexia are pleiotropically influenced by a putative quantitative trait locus on chromosome 3...
  51. ncbi The extent to which psychometric tests differentiate subgroups of children with SLI
    G Conti-Ramsden
    Centre for Educational Needs, School of Education, University of Manchester, England
    J Speech Lang Hear Res 40:765-77. 1997
    ..The findings are discussed in the context of other approaches to the classification of language impairment in children with special reference to the work of Rapin and Allen (1987)...
  52. pmc The broader language phenotype of autism: a comparison with specific language impairment
    Andrew J O Whitehouse
    University of Oxford, UK
    J Child Psychol Psychiatry 48:822-30. 2007
    ..Whether these behaviours are indicative of a common underlying genetic cause or a superficial similarity is unclear...
  53. ncbi Speech sound disorder influenced by a locus in 15q14 region
    Catherine M Stein
    Department of Epidemiology and Biostatistics, Case Western Reserve University, and Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, OH 44106, USA
    Behav Genet 36:858-68. 2006
    ..97 to 2.17, P=0.0633). These results suggest shared genetic determinants in this chromosomal region for SSD, autism, and PWS/AS...
  54. pmc Heritable risk factors associated with language impairments
    J G Barry
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, UK
    Genes Brain Behav 6:66-76. 2007
    ..This suggests that non-word repetition serves as a marker of a family risk for language impairment. The paper concludes with a discussion of issues associated with ascertainment of specific language impairment (SLI)...
  55. pmc Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits
    Kay D Macdermot
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 76:1074-80. 2005
    ..This endeavor will be crucial for gaining insight into the role of FOXP2 in human cognition...
  56. ncbi The interface between ADHD and language impairment: an examination of language, achievement, and cognitive processing
    N J Cohen
    Hincks Dellcrest Centre for Children s Mental Health, University of Toronto, Ontario, Canada
    J Child Psychol Psychiatry 41:353-62. 2000
    ..As most therapies are verbally based it is notable that language competence is rarely evaluated systematically before such therapies are undertaken...
  57. ncbi Nonword repetition and child language impairment
    C Dollaghan
    Department of Communication Science and Disorders, University of Pittsburgh, PA 15260, USA
    J Speech Lang Hear Res 41:1136-46. 1998
    ..Nonword repetition may have considerable clinical utility as a screening measure for language impairment in children. Information on the likelihood ratios associated with all diagnostic tests of language is badly needed...
  58. ncbi Genetic influence on rolandic epilepsy
    Bhavna Bali
    Ann Neurol 57:464-5; author reply 465. 2005
  59. pmc Neural mechanisms of selective auditory attention are enhanced by computerized training: electrophysiological evidence from language-impaired and typically developing children
    Courtney Stevens
    University of Oregon, USA
    Brain Res 1205:55-69. 2008
    ....
  60. ncbi Nonword repetition in specific language impairment: more than a phonological short-term memory deficit
    Lisa M D Archibald
    Department of Psychology, University of Western Ontario, London, Ontario, Canada
    Psychon Bull Rev 14:919-24. 2007
    ....
  61. ncbi Weak coherence, no theory of mind, or executive dysfunction? Solving the puzzle of pragmatic language disorders
    Ingerith Martin
    School of Psychology, University of New South Wales, Sydney 2052, Australia
    Brain Lang 85:451-66. 2003
    ..It is recommended that a new, more convergent approach to investigating the causes of pragmatic language disability be adopted...
  62. ncbi Reduced neural integration of letters and speech sounds links phonological and reading deficits in adult dyslexia
    Vera Blau
    University of Maastricht, Faculty of Psychology and Neuroscience, Department of Cognitive Neuroscience, PO Box 616, 6200 MD Maastricht, The Netherlands
    Curr Biol 19:503-8. 2009
    ..The data provide a neurofunctional account of developmental dyslexia, in which phonological processing deficits are linked to reading failure through a deficit in neural integration of letters and speech sounds...
  63. ncbi Genes, language development, and language disorders
    Shelley D Smith
    Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska 68198 5456, USA
    Ment Retard Dev Disabil Res Rev 13:96-105. 2007
    ..Understanding these processes can form the basis for refined procedures for diagnosis and treatment...
  64. ncbi Auditory processing deficits in children with reading and language impairments: can they (and should they) be treated?
    G M McArthur
    Macquarie Centre for Cognitive Science, Macquarie University, NSW 2109, Australia
    Cognition 107:946-77. 2008
    ..These results suggest that auditory processing deficits can be treated successfully in children with SRD and SLI but that this does not help them acquire new reading, spelling, or spoken language skills...
  65. ncbi Phonological short-term memory, language and literacy: developmental relationships in early adolescence in young people with SLI
    Gina Conti-Ramsden
    Human Communication and Deafness, School of Psychological Sciences, The University of Manchester, Humanities Devas Street Building, Oxford Road, Manchester M13 9PL, UK
    J Child Psychol Psychiatry 48:147-56. 2007
    ....
  66. pmc High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, The University of Oxford, Oxford, OX3 7BN, UK
    Am J Hum Genet 81:1232-50. 2007
    ..The identified targets suggest roles in modulating synaptic plasticity, neurodevelopment, neurotransmission, and axon guidance and represent novel entry points into in vivo pathways that may be disturbed in speech and language disorders.
  67. ncbi Effects of computer-based intervention through acoustically modified speech (Fast ForWord) in severe mixed receptive-expressive language impairment: outcomes from a randomized controlled trial
    Wendy Cohen
    University of Edinburgh, UK
    J Speech Lang Hear Res 48:715-29. 2005
    ..Thus, the findings from this RCT do not support the efficacy of FFW as an intervention for children with severe mixed receptive-expressive SLI...
  68. ncbi Molecular windows into speech and language disorders
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Folia Phoniatr Logop 59:130-40. 2007
    ..I demonstrate ways of bridging the gaps between molecules, neurons and the brain, which will provide a new understanding of the aetiology of speech and language impairments...
  69. ncbi Deletion of 7q31.1 supports involvement of FOXP2 in language impairment: clinical report and review
    P A Lennon
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Am J Med Genet A 143:791-8. 2007
    ..It is unclear however whether the AUTS1 (autistic spectrum 1) locus, highly linked to 7q31, overlaps with the SPCH1 and FOXP2...
  70. pmc Individual differences in auditory processing in specific language impairment: a follow-up study using event-related potentials and behavioural thresholds
    Dorothy V M Bishop
    Department of Experimental Psychology, University of Oxford, UK
    Cortex 41:327-41. 2005
    ..This study emphasises the variability seen in SLI, and the importance of studying individual cases rather than focusing on group means...
  71. ncbi DeFries-Fulker analysis of twin data with skewed distributions: cautions and recommendations from a study of children's use of verb inflections
    D V M Bishop
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
    Behav Genet 35:479-90. 2005
    ..Both these features were seen in data from a test of verb inflections given to 174 6-year-old twin pairs, suggesting that a single major gene may be implicated in causing impaired grammatical development...
  72. ncbi Familial loading in specific language impairment: patterns of differences across proband characteristics, gender and relative type
    G Conti-Ramsden
    The University of Manchester, Oxford Road, Manchester, United Kingdom
    Genes Brain Behav 6:216-28. 2007
    ..In contrast, higher levels of SLI among relatives of female rather than male probands was entirely disproved...
  73. ncbi Multivariate linkage analysis of specific language impairment (SLI)
    Anthony P Monaco
    The SLI Consortium SLIC
    Ann Hum Genet 71:660-73. 2007
    ..In contrast, SLI2 appeared to have influences on a selection of expressive and receptive language phenotypes in addition to non-word repetition, but did not show linkage to literacy phenotypes...
  74. ncbi Using mismatch negativity to study central auditory processing in developmental language and literacy impairments: where are we, and where should we be going?
    D V M Bishop
    Department of Experimental PsychologyUniveristy of Oxford, Oxford, United Kingdom
    Psychol Bull 133:651-72. 2007
    ..The article concludes with recommendations for improving this state of affairs...
  75. ncbi Speech and language impairment and oromotor dyspraxia due to deletion of 7q31 that involves FOXP2
    Susan Zeesman
    Department of Pediatrics, McMaster University, Hamilton, Canada
    Am J Med Genet A 140:509-14. 2006
    ..Cytogenetic and molecular analysis of this region should be considered for other individuals displaying similar characteristics...
  76. ncbi Genetic influences on specific versus nonspecific language impairment in 4-year-old twins
    Marianna E Hayiou-Thomas
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London
    J Learn Disabil 38:222-32. 2005
    ..18 for SLI and .52 for NLI. Probandwise cross-concordances were suggestive of some genetic overlap between these two groups, but not with a subgroup of children with more severe cognitive delay...
  77. ncbi Are developmental disorders like cases of adult brain damage? Implications from connectionist modelling
    Michael Thomas
    Neurocognitive Development Unit, Institute of Child Health and School of Psychology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom
    Behav Brain Sci 25:727-50; discussion 750-87. 2002
    ....
  78. ncbi Self-esteem, shyness, and sociability in adolescents with specific language impairment (SLI)
    Ruth Wadman
    Human Communication and Deafness, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom
    J Speech Lang Hear Res 51:938-52. 2008
    ..To determine if lower global self-esteem, shyness, and low sociability are outcomes associated with SLI in adolescence. Possible concurrent predictive relationships and gender differences were also examined...
  79. ncbi Explaining and controlling regression to the mean in longitudinal research designs
    Xuyang Zhang
    Department of Speech Pathology and Audiology, University of Iowa, Iowa City 52242, USA
    J Speech Lang Hear Res 46:1340-51. 2003
    ..In addition to a formal analysis of the regression to the mean, the features of regression to the mean are demonstrated via a simulation...
  80. ncbi The role of genes in the etiology of specific language impairment
    D V M Bishop
    Department of Experimental Psychology, University of Oxford, UK
    J Commun Disord 35:311-28. 2002
    ..Future genetic studies of SLI may be most effective if they use measures of underlying cognitive processes, rather than relying on conventional psychometric definitions of disorder...
  81. ncbi Genetic and environmental mediation of the relationship between language and nonverbal impairment in 4-year-old twins
    Essi Viding
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, England
    J Speech Lang Hear Res 46:1271-82. 2003
    ..This finding held even when we excluded those children with language impairment whose nonverbal score indicated general cognitive delay. These results point to a general genetic factor that includes both language and nonverbal problems...
  82. pmc Language features in a mother and daughter of a chromosome 7;13 translocation involving FOXP2
    J Bruce Tomblin
    Department of Speech Pathology and Audiology, University of Iowa, WJSHC, Iowa City, IA, USA
    J Speech Lang Hear Res 52:1157-74. 2009
    ....
  83. ncbi Two further investigations of autobiographical memory in semantic dementia
    Kim S Graham
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Cortex 39:729-50. 2003
    ..Together, the two experiments further confirm that patients with semantic dementia show a modality independent autobiographical memory deficit, with better retrieval of recent events...
  84. ncbi Autistic symptomatology and language ability in autism spectrum disorder and specific language impairment
    Tom Loucas
    School of Psychology and Clinical Language Sciences, University of Reading, UK
    J Child Psychol Psychiatry 49:1184-92. 2008
    ..This study investigates whether the co-occurrence of ASD and language impairment is associated with differences in severity or pattern of autistic symptomatology or language profile...
  85. ncbi Co-occurring disorders in children who stutter
    Gordon W Blood
    Department of Communication Sciences and Disorders, 110 Moore Building, The Pennsylvania State University, University Park, PA 16802, USA
    J Commun Disord 36:427-48. 2003
    ..the (a) percentage of children who stutter with co-occurring non-speech disorders, speech disorders, and language disorders, and (b) frequency, length of sessions, and type of treatment services provided for children who stutter ..
  86. pmc Association of specific language impairment (SLI) to the region of 7q31
    Erin K O'Brien
    Department of Otolaryngology, University of Iowa, Iowa City, IA 52242, USA
    Am J Hum Genet 72:1536-43. 2003
    ....
  87. ncbi Deciphering the genetic basis of speech and language disorders
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom
    Annu Rev Neurosci 26:57-80. 2003
    ..The molecular genetic approach has potential for dissecting neurological pathways underlying speech and language disorders, but such investigations are only just beginning.
  88. ncbi A grammatical specific language impairment in children: an autosomal dominant inheritance?
    H K van der Lely
    Department of Psychology, Birkbeck College, University of London, United Kingdom
    Brain Lang 52:484-504. 1996
    ..The implications for the biological, domain-specific, and modular bases to language are discussed...
  89. ncbi Pre-literacy skills of subgroups of children with speech sound disorders
    Nancy A Raitano
    Department of Psychology, University of Denver, Denver, CO 80208, USA
    J Child Psychol Psychiatry 45:821-35. 2004
    ..Previous studies have documented that two important dimensions of heterogeneity are the presence of a comorbid language impairment (LI) and the persistence of SSD, but these factors have not been examined separately...
  90. ncbi Anatomical risk factors that distinguish dyslexia from SLI predict reading skill in normal children
    Christiana M Leonard
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville 32611, USA
    J Commun Disord 35:501-31. 2002
    ..These results suggest that PD and SLI are qualitatively different disorders associated with anatomical deviations in opposite directions from the population mean...
  91. ncbi FOXP2 polymorphisms in patients with schizophrenia
    Julio Sanjuan
    Unidad de Psiquiatria, Facultad de Medicina, Hospital Clinico, Universitat de Valencia, Blasco Ibaez 15, 46010 Valencia, Spain
    Schizophr Res 73:253-6. 2005
    ..FOXP2 was described as the first gene involved in our ability to acquire spoken language. The main objective of this study was to compare the distribution of FOXP2 gene polymorphisms between patients with schizophrenia and healthy controls...
  92. ncbi Grammatical language impairment and the specificity of cognitive domains: relations between auditory and language abilities
    Heather K J van der Lely
    Centre for Developmental Language Disorders and Cognitive Neuroscience, Dept of Human Communication Science, University College London, 2 Wakefield Street, London, WC1N 1PF, UK
    Cognition 94:167-83. 2004
    ..The findings, from at least those G-SLI children who do not exhibit any auditory deficits, provide further evidence supporting the existence of a primary domain-specific deficit underlying G-SLI...
  93. ncbi Heritability of poor language achievement among twins
    J B Tomblin
    The University of Iowa, Iowa City 52242, USA
    J Speech Lang Hear Res 41:188-99. 1998
    ..These results support the hypothesis that genetic factors contribute to the liability of poor language achievement in children who do not present other developmental or sensory disorders...
  94. ncbi Working memory and comprehension in children with specific language impairment: what we know so far
    James W Montgomery
    Department of Speech and Hearing Sciences, University of North Carolina, CB 7190, Chapel Hill, NC 27599, USA
    J Commun Disord 36:221-31. 2003
    ..The reader will also be provided a variety of clinical suggestions on how to assess and treat the working memory and language processing problems of children with SLI. Finally, some suggestions for future research will also be offered...
  95. ncbi Development of the Children's Communication Checklist (CCC): a method for assessing qualitative aspects of communicative impairment in children
    D V Bishop
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    J Child Psychol Psychiatry 39:879-91. 1998
    ..The majority of children with pragmatic language impairments did not have any evidence of restricted interests or significant difficulties in the domains of social relationships...
  96. ncbi Different origin of auditory and phonological processing problems in children with language impairment: evidence from a twin study
    D V Bishop
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    J Speech Lang Hear Res 42:155-68. 1999
    ..In general, CNRep was a better predictor of low language test scores than ART, but ART did make a significant independent contribution in accounting for variance in a test of grammatical understanding...
  97. pmc FOXP2 is not a major susceptibility gene for autism or specific language impairment
    D F Newbury
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 70:1318-27. 2002
    ..AUTS1 locus), leading to the proposal that a single genetic factor on 7q31 contributes to both autism and language disorders. In the present study, we directly evaluate the impact of the FOXP2 gene with regard to both complex ..
  98. pmc Examination of potential overlap in autism and language loci on chromosomes 2, 7, and 13 in two independent samples ascertained for specific language impairment
    Christopher W Bartlett
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA
    Hum Hered 57:10-20. 2004
    ..2003). Our results indicate that using samples selected for components of the autism phenotype may be a useful adjunct to autism genetics...
  99. ncbi Auditory event-related brain potentials in children with specific language impairment
    Marianne Ors
    Department of Clinical Neuroscience, Lund University, Sweden
    Eur J Paediatr Neurol 6:47-62. 2002
    ..The results are further discussed within the framework of context updating in working memory...
  100. ncbi Language comprehension in boys with fragile X syndrome and boys with Down syndrome
    J Price
    Frank Porter Graham Child Development Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Intellect Disabil Res 51:318-26. 2007
    ....
  101. ncbi [The influence of the social perception of emotions in the formal language of children with Asperger's syndrome or high-functioning autism]
    R Ayuda-Pascual
    DELETREA Diagnostico, Evaluacion del Lenguaje y Tratamiento de Espectro Autista, 28014 Madrid, Espana
    Rev Neurol 44:S57-9. 2007
    ....

Research Grants64

  1. MORPHOLOGICAL DEFICITS IN SPECIFIC LANGUAGE IMPAIRMENT
    Laurence Leonard; Fiscal Year: 2007
    ..Such a finding could lead to a uniform theory of how language impairment might develop and persist among children acquiring English. ..
  2. GRAMMATICAL MORPHOLOGY IN SPECIFIC LANGUAGE IMPAIRMENT
    Laurence Leonard; Fiscal Year: 2004
    ..abstract_text> ..
  3. DISCRIMINATING SLI AND APD IN SCHOOL-AGE CHILDREN
    Carol Miller; Fiscal Year: 2007
    ..The results will form the foundation for further research employing larger, more stringently selected samples and both behavioral and electrophysiological measures. ..
  4. Treatment of Lexical Deficits in Young Children with SLI
    SHELLEY I GRAY; Fiscal Year: 2010
    ..abstract_text> ..
  5. LEXICAL DEFICIT--YOUNG CHILD W/ SPECIFIC LANG IMPAIRMENT
    Shelley Gray; Fiscal Year: 2002
    ..abstract_text> ..
  6. Psycholinguistic and Socioemotional Profiling of SLI and ADHD
    Sean Redmond; Fiscal Year: 2008
    ..Given the academic and social risks associated with misdiagnosis and the poor prognosis associated with untreated comorbidity, this research impacts upon several key public health concerns. [unreadable] [unreadable] [unreadable]..
  7. Collaboration on Specific Language Impairment
    JAMES TOMBLIN; Fiscal Year: 2005
    ..abstract_text> ..
  8. The Genetics of Specific Language Impairment
    JAMES TOMBLIN; Fiscal Year: 2009
    ..coupled with empirical studies on the heritability of individual differences in language development and language disorders support the hypothesis that the capacity for language development in humans is genetically influenced...
  9. Effects of Fast ForWord on Language Processing
    Marc Fey; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  10. THOUGHT DISORDER: A DEVELOPMENTAL DISABILITY IN EPILEPSY
    Rochelle Caplan; Fiscal Year: 2003
    ..Weekly seizure frequency data will be obtained on a monthly basis from the parent during the 2 years. ..
  11. Pediatric Thought Disorder: Insights from Neuroimaging
    Rochelle Caplan; Fiscal Year: 2006
    ..abstract_text> ..
  12. ERP & Behavioral Predictors of Language Intervention
    Paul Yoder; Fiscal Year: 2008
    ..Multiple regression, multivariate permutation tests, and growth curve analyses will be used to test the research questions. Five years of funding are requested. ..
  13. EARLY COMMUNICATION INTERVENTION IN AUTISTIC CHILDREN
    Paul Yoder; Fiscal Year: 2004
    ..Assessments of communication, vocabulary, and motor imitation will occur at the pre-treatment, port-treatment, and 6 month follow-up periods. Examiners and coders will be blind to treatment assignment. ..
  14. Maternal Emotional Well-Being and Fragile X Syndrome
    Leonard Abbeduto; Fiscal Year: 2006
    ....
  15. Child Spontaneous Language Use: Gene-Environment Effects
    LAURA DETHORNE; Fiscal Year: 2009
    ..Developing a more informed model of how genetic and environmental factors work together to yield language outcomes has important implications for developing programs and strategies that will facilitate child language ability. ..
  16. Contributions of Neural Memory Circuits
    Michael T Ullman; Fiscal Year: 2010
    ....
  17. Short-Term and Long-Term Memory Systems in Word Learning
    Prahlad Gupta; Fiscal Year: 2006
    ..issues is of key importance in understanding the underpinnings of language, and in improved understanding of language disorders. This project will test and further develop a novel theoretical framework that relates the mechanisms of ..
  18. Treatment for Language Processing Deficits in Adults with Right Brain Damage
    Connie A Tompkins; Fiscal Year: 2010
    ..abstract_text> ..
  19. Genetic Determinants of Brain Structure and Disease Risk in Schizophrenia
    Thomas H Wassink; Fiscal Year: 2010
    ....
  20. Definition and Development of the Phenotype of Autism
    Sally Rogers; Fiscal Year: 2006
    ....
  21. Receptive language skills in developmental language disorder
    ELENA M PLANTE; Fiscal Year: 2010
    ..Therefore, this research will provide a context for the development of improved intervention methods. ..
  22. The Neurodevelopmental Basis of Speech Discrimination
    Valerie Shafer; Fiscal Year: 2009
    ..bilingual) on speech discrimination using brain and behavioral indices of processing of these stimuli. ..
  23. Identification of Adults with Developmental Language Impairments
    Elena Plante; Fiscal Year: 2007
    ..This is a critical first step for genetic studies of this disorder, as well as research into the longterm outcome of this disorder and the residual deficits that characterize affected adults. [unreadable] [unreadable] [unreadable]..
  24. The impact of inhibition control on working memory in children with SLI
    Klara Marton; Fiscal Year: 2007
    ..Inhibition control may underlie many of those difficulties that children with SLI experience in everyday learning situations. [unreadable] [unreadable] [unreadable]..
  25. Diagnostic Markers of Language Impairment in Bilinguals
    ELIZABETH D PENA; Fiscal Year: 2010
    ..abstract_text> ..
  26. Phenotype Assessment Tools:Bilingual(Spanish-English)
    ELIZABETH PENA; Fiscal Year: 2008
    ..This application addresses this concern by working to develop an assessment protocol to improve identification of bilingual children with language impairment. [unreadable] [unreadable]..
  27. RECEPTIVE SKILLS IN DEVELOPMENTAL LANGUAGE DISORDER
    Elena Plante; Fiscal Year: 2007
    ..Therefore, this research will provide a context for the development of improved intervention methods. ..
  28. Neural Correlates of Aphasia Treatment and Recovery: fMRI Investigations
    Cynthia Thompson; Fiscal Year: 2009
    ..Additionally, we propose to examine theoretically motivated extensions of the complexity method to new domains of language treatment. ..
  29. Cognitive Representation in Specific Language Impairment
    Julia L Evans; Fiscal Year: 2010
    ....
  30. Multimodal Neuroimaging of White Matter in Autism
    Martha Herbert; Fiscal Year: 2009
    ..Our study design will also detect alternate outcomes and will yield data relevant for multiple levels of translational research. ..
  31. IDENTIFICATION OF GENES INFLUENCING DYSLEXIA
    Shelley Smith; Fiscal Year: 2001
    ..Linkage and association analysis will be used to verify that a candidate gene effects reading disability in the 175 nuclear families. ..
  32. A MULTI-FACETED SEARCH FOR AUTISM DISEASE GENES
    Thomas Wassink; Fiscal Year: 2004
    ..Taken together, the training plan and research proposal provide for a breadth of training, the potential for meaningful discovery, and support for the establishment of an independent research career. ..
  33. Working memory capacity in children with SLI
    Klara Marton; Fiscal Year: 2004
    ....
  34. Teaching Nonverbal Children with Autism Useful Speech
    Sally Rogers; Fiscal Year: 2003
    ..4) Finally, a short-term pilot study using random assignment of matched participants and single subject design will be conducted to examine efficacy of each approach. ..
  35. Infant hearing for modulated tones
    Barbara Cone Wesson; Fiscal Year: 2003
    ..This research will also result in methods for assessing threshold sensitivity and sound discrimination in infants that can be applied to those at risk for hearing loss or other auditory dysfunction. ..
  36. AUTISM--BRAIN MORPHOMETRY AND COGNITIVE NEUROSCIENCE
    Martha Herbert; Fiscal Year: 2003
    ..The study will be performed on subjects from two NIH-funded projects, the Autism and Language Disorders Nosology Project, NINDS 20489; and the Language in Autism: Clinical and Basic Studies Project, NIDCD PO1 DC ..
  37. CONTRIBUTION OF NEURAL MEMORY CIRCUITS TO LANGUAGE
    Michael Ullman; Fiscal Year: 2002
    ..2) These circuits also subserve fact and skill use, respectively. (3) The basal ganglia play a similar role in motor activity and grammatical rule use. ..
  38. EVALUATING GRAMMATICAL ASYNCHRONY IN CHILDREN WITH SLI
    Pamela Hadley; Fiscal Year: 2002
    ..abstract_text> ..
  39. The Contribution of Working Memory to Narrative Discour*
    Donna Boudreau; Fiscal Year: 2005
    ..Findings have theoretical and clinical implications for the assessment and intervention of language impairments. ..
  40. BILINGUAL CHILDREN'S USE OF SPANISH GENDER AGREEMENT
    RAQUEL ANDERSON; Fiscal Year: 2002
    ..These results will also be utilized to extend the research to examine other Spanish grammatical aspects in similar populations. ..
  41. A QUANTITATIVE GENETIC MEASURE OF AUTISTIC TRAITS
    John Constantino; Fiscal Year: 2002
    ..If the SRS compares favorably with the ADI-R, the SRS could feasibly be used to study the genetics of autism by examining the genetic structure of autistic traits in whole populations. ..
  42. Development and Evaluation of a Virtual Aphasia Clinici*
    Cynthia Thompson; Fiscal Year: 2006
    ..If successful, this work will result in new directions for the management of speech and language disorders that incorporate and take advantage of advances in computer technology.
  43. MOLECULAR GENETICS OF AUTISM
    Thomas Wassink; Fiscal Year: 2006
    ..severe language impairment, and by overlapping linkage findings from families segregating various speech and language disorders. Based on this, members of our research group recently reported evidence suggesting that WNT2, a ..
  44. COMPREHENSION IMPAIRMENT AND RIGHT BRAIN DAMAGE
    Connie Tompkins; Fiscal Year: 2006
    ..abstract_text> ..
  45. 1/2 Development of a Screening Interview for Research Studies of ASD
    Catherine Lord; Fiscal Year: 2010
    ....
  46. Stuttering Therapy and Neurophysiological Interaction
    Roger J Ingham; Fiscal Year: 2010
    ..The overall study also constitutes a Phase II treatment efficacy study that will determine the need for a Phase III treatment trial of the MPI program. ..
  47. EARLY IDENTIFICATION OF RISK FOR LANGUAGE DISORDER
    Donna Thal; Fiscal Year: 2004
    ..abstract_text> ..
  48. Neurobiological Foundations of reading (dis)ability
    Kenneth R Pugh; Fiscal Year: 2010
    ....
  49. Effects of a Systematic Categorization Program in TBI
    Fofi Constantinidou; Fiscal Year: 2004
    ..The long-term objective of this research is to develop effective approaches to remediate complex cognitive processes such as categorization, decision-making and problem solving in patients with moderate to severe (TBI). ..
  50. Integration of MSI/fMRI Studies of Reading
    Andrew Papanicolaou; Fiscal Year: 2004
    ..Together these efforts will expand the interpretability of imaging data by direct comparison and integration of the techniques and lead to a more elaborated theory of the cerebral mechanisms underlying reading. ..
  51. The Relation Between Hypercortisolemia and Aphasia
    Jacqueline Laures Gore; Fiscal Year: 2007
    ..abstract_text> ..
  52. FMRI/Pathology/Anterior Cingulate/Frontoinsular Cortex
    WILLIAM SEELEY; Fiscal Year: 2007
    ..The proposed research seeks to benefit the public health by clarifying the biological basis of dementia, ultimately promoting earlier diagnosis and better treatments for dementia patients. ..
  53. Mutual Regulation in Very Low Birthweight Preschoolers
    Marjorie Beeghly; Fiscal Year: 2005
    ..This information will enhance our ability to design and implement effective prevention and intervention services for VLBW children and their families. ..
  54. COGNITIVE & NEUROBIOL MECHANISMS IN READING DISABILITY
    Kenneth Pugh; Fiscal Year: 2005
    ....
  55. GENETICS OF COGNITION IN ADULT TURNER SYNDROME
    Judith Ross; Fiscal Year: 2005
    ..Characterization of specific TS causative genes would provide insight into the pathophysiology of 45,X, Turner syndrome, as well as the process of normal neurocognitive development. ..
  56. INTELLIGIBILITY ASSESSMENT IN DYSARTHRIA
    Raymond Kent; Fiscal Year: 2005
    ..The data on dysarthria will be integrated with data on speech development and normal adult speech in a neural network model of speech production that is based on internal models of auditory and articulatory representations of speech. ..
  57. White matter myelin abnormalities in schizophrenia
    Marek Kubicki; Fiscal Year: 2004
    ..Results from this study will allow us to understand better white matter alterations in schizophrenia, and add to what we know about connectivity abnormalities in schizophrenia. ..
  58. Spoken language production and childhood stuttering
    Julie Anderson; Fiscal Year: 2006
    ..Findings from these projects will provide meaningful insights into the role that salient linguistic processes play in the initiation and/or cause of instances of stuttering in children. [unreadable] [unreadable]..
  59. The PTP, STEP, Regulates Amphetamine Actions
    Paul Lombroso; Fiscal Year: 2008
    ..We show preliminary feasibility data on this approach. A complementary set of experiments will study the STEP knock-out mouse that we predict is hypersensitive to stimulant treatment. ..
  60. GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURES
    Ruth Ottman; Fiscal Year: 2007
    ..abstract_text> ..
  61. Neurodevelopment and HIV/AIDS
    Annelies Van Rie; Fiscal Year: 2005
    ....
  62. Neural Basis of Semantic Constraints on Adjective Order
    David Kemmerer; Fiscal Year: 2006
    ..This will be done by recording event-related potentials in normal adults while they read examples of natural and unnatural adjective orders. [unreadable] [unreadable]..