food deprivation


Summary: The withholding of food in a structured experimental situation.

Top Publications

  1. ncbi The comparative physiology of food deprivation: from feast to famine
    Tobias Wang
    Department of Zoophysiology, Aarhus University, 8000 Aarhus C, Denmark
    Annu Rev Physiol 68:223-51. 2006
  2. pmc Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
    F Damiola
    , Sciences II, , CH-1211 Geneva, Switzerland
    Genes Dev 14:2950-61. 2000
  3. ncbi Lifespan extension in Caenorhabditis elegans by complete removal of food
    Tammi L Kaeberlein
    Department of Microbiology, University of Washington, Seattle, WA, USA
    Aging Cell 5:487-94. 2006
  4. ncbi Effects of short-term food deprivation on interoceptive awareness, feelings and autonomic cardiac activity
    Beate M Herbert
    Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tuebingen, Eberhard Karls University Tuebingen, Germany
    Biol Psychol 89:71-9. 2012
  5. ncbi The relative-reinforcing value of food under differing levels of food deprivation and restriction
    Hollie A Raynor
    State University of New York, University at Buffalo, Buffalo, NY 14214 3000, USA
    Appetite 40:15-24. 2003
  6. ncbi Role and regulation of starvation-induced autophagy in the Drosophila fat body
    Ryan C Scott
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis 55455 USA
    Dev Cell 7:167-78. 2004
  7. ncbi Fuel, fasting, fear: routine metabolic rate and food deprivation exert synergistic effects on risk-taking in individual juvenile European sea bass
    Shaun S Killen
    Institut des Sciences de l Evolution de Montpellier, UMR 5554 CNRS Université de Montpellier 2, Station Mediterraneenne de l Environnement Littoral, 1 Quai de la Daurade, F 34200 Sète, France
    J Anim Ecol 80:1024-33. 2011
  8. ncbi Food deprivation and emotional reactions to food cues: implications for eating disorders
    D J Drobes
    NIMH Center for the Study of Emotion and Attention, University of Florida, Box 100165 HSC, Gainsville, FL 32610, USA
    Biol Psychol 57:153-77. 2001
  9. ncbi Rapid development of fasting-induced hepatic lipidosis in the American mink (Neovison vison): effects of food deprivation and re-alimentation on body fat depots, tissue fatty acid profiles, hematology and endocrinology
    Kirsti Rouvinen-Watt
    Department of Plant and Animal Sciences, Nova Scotia Agricultural College, Truro, NS, Canada
    Lipids 45:111-28. 2010
  10. ncbi Discrimination of circadian phase in intact and suprachiasmatic nuclei-ablated rats
    R E Mistlberger
    Department of Psychology, Simon Fraser University, Burnaby, B C, Canada
    Brain Res 739:12-8. 1996

Detail Information

Publications254 found, 100 shown here

  1. ncbi The comparative physiology of food deprivation: from feast to famine
    Tobias Wang
    Department of Zoophysiology, Aarhus University, 8000 Aarhus C, Denmark
    Annu Rev Physiol 68:223-51. 2006
    The ability of animals to survive food deprivation is clearly of considerable survival value. Unsurprisingly, therefore, all animals exhibit adaptive biochemical and physiological responses to the lack of food...
  2. pmc Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
    F Damiola
    , Sciences II, , CH-1211 Geneva, Switzerland
    Genes Dev 14:2950-61. 2000
    ..Food-induced phase resetting proceeds faster in liver than in kidney, heart, or pancreas, but after 1 wk of daytime feeding, the phases of circadian gene expression are similar in all examined peripheral tissues...
  3. ncbi Lifespan extension in Caenorhabditis elegans by complete removal of food
    Tammi L Kaeberlein
    Department of Microbiology, University of Washington, Seattle, WA, USA
    Aging Cell 5:487-94. 2006
    ..Removal of bacterial food also increases lifespan when initiated in postreproductive adults, suggesting that dietary restriction started during middle age can result in a substantial longevity benefit that is independent of reproduction...
  4. ncbi Effects of short-term food deprivation on interoceptive awareness, feelings and autonomic cardiac activity
    Beate M Herbert
    Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tuebingen, Eberhard Karls University Tuebingen, Germany
    Biol Psychol 89:71-9. 2012 investigated changes of interoceptive awareness and cardiac autonomic activity induced by short-term food deprivation and its relationship to hunger and affective experience...
  5. ncbi The relative-reinforcing value of food under differing levels of food deprivation and restriction
    Hollie A Raynor
    State University of New York, University at Buffalo, Buffalo, NY 14214 3000, USA
    Appetite 40:15-24. 2003
    b>Food deprivation and restriction both increase food consumption...
  6. ncbi Role and regulation of starvation-induced autophagy in the Drosophila fat body
    Ryan C Scott
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis 55455 USA
    Dev Cell 7:167-78. 2004
    ..Thus, in cells lacking TOR, autophagy plays a protective role that is dominant over its potential role as a growth suppressor...
  7. ncbi Fuel, fasting, fear: routine metabolic rate and food deprivation exert synergistic effects on risk-taking in individual juvenile European sea bass
    Shaun S Killen
    Institut des Sciences de l Evolution de Montpellier, UMR 5554 CNRS Université de Montpellier 2, Station Mediterraneenne de l Environnement Littoral, 1 Quai de la Daurade, F 34200 Sète, France
    J Anim Ecol 80:1024-33. 2011
    ..Such a relationship could be exacerbated by food deprivation if a higher metabolic demand also causes greater mass loss and hunger. 2...
  8. ncbi Food deprivation and emotional reactions to food cues: implications for eating disorders
    D J Drobes
    NIMH Center for the Study of Emotion and Attention, University of Florida, Box 100165 HSC, Gainsville, FL 32610, USA
    Biol Psychol 57:153-77. 2001
    ..In experiment 1, normal college students were assigned to 0-, 6- or 24-h of food deprivation prior to presentations of standard emotional and food-related pictures...
  9. ncbi Rapid development of fasting-induced hepatic lipidosis in the American mink (Neovison vison): effects of food deprivation and re-alimentation on body fat depots, tissue fatty acid profiles, hematology and endocrinology
    Kirsti Rouvinen-Watt
    Department of Plant and Animal Sciences, Nova Scotia Agricultural College, Truro, NS, Canada
    Lipids 45:111-28. 2010
    ..the timeline and characterize the development of hepatic lipidosis in mink in response to 0-7 days of food deprivation and liver recovery after 28 days of re-feeding...
  10. ncbi Discrimination of circadian phase in intact and suprachiasmatic nuclei-ablated rats
    R E Mistlberger
    Department of Psychology, Simon Fraser University, Burnaby, B C, Canada
    Brain Res 739:12-8. 1996
    ..The results provide the first clear evidence that the circadian system in a mammal can function as a consulted clock that provides discriminative time cues for cognitive processes subserving behavioral plasticity...
  11. ncbi Effects of deprivation on hedonics and reinforcing value of food
    Leonard H Epstein
    Department of Pediatrics, School of Medicine and Biomedical Sciences, University at Buffalo, G56 Farber Hall, 3435 Main Street, Buffalo, NY 14214 3000, USA
    Physiol Behav 78:221-7. 2003
    ..These results suggest that hedonics and the reinforcing value of food are separate processes in humans, and they may independently influence eating behavior...
  12. ncbi Insulin/IGF-1 receptor signaling enhances biosynthetic activity and fat mobilization in the initial phase of starvation in adult male C. elegans
    Kien Thiam Tan
    Laboratory of Molecular Pathology, Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Cell Metab 14:390-402. 2011
    ..Upon depletion of the intestinal lipids, further food deprivation results in a significant reduction in metabolic activity in the starved male worms...
  13. ncbi The regulation of feeding and metabolism in response to food deprivation in Caenorhabditis elegans
    Sarah Luedtke
    School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK
    Invert Neurosci 10:63-76. 2010
    This review considers the factors involved in the regulation of feeding and metabolism in response to food deprivation using Caenorhabditis elegans as a model organism...
  14. ncbi Hypothalamic orexin neurons regulate arousal according to energy balance in mice
    Akihiro Yamanaka
    Institute of Basic Medical Science, University of Tsukuba, 305 8575, Ibaraki, Japan
    Neuron 38:701-13. 2003
    ..Transgenic mice, in which orexin neurons are ablated, fail to respond to fasting with increased wakefulness and activity. These findings indicate that orexin neurons provide a crucial link between energy balance and arousal...
  15. ncbi A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding
    Keiko Hirota
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    J Biol Chem 283:32432-41. 2008
  16. ncbi The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain
    Robert Fredriksson
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Biomedical Center, Uppsala, Sweden
    Endocrinology 149:2062-71. 2008
    ..The FTO was significantly up-regulated (41%) in the hypothalamus of rats after 48-h food deprivation. We also found a strong negative correlation of the FTO expression level with the expression of orexigenic ..
  17. pmc Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique
    Craig A Goodman
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    FASEB J 25:1028-39. 2011
    ..In addition, IV-SUnSET detected food deprivation-induced decreases in PS in the heart, kidney, and skeletal muscles, with similar changes being visualized ..
  18. pmc Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 158:451-61. 2009
    ..Here we evaluate endocannabinoid dysregulation in the small intestine of mice with diet-induced obesity (DIO) and in peripheral tissues of Zucker and lean rats following food deprivation and re-feeding.
  19. ncbi Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice
    Masashi Akiyama
    Department of Pharmacology, School of Science and Engineering, Waseda University, 2 7 5 Higashifushimi, Nishitokyo, 202 0021, Japan
    Eur J Neurosci 20:3054-62. 2004
    ..Based on these results, we suggest that activity of the orexin neuron in the LHA contributes to the promotion and maintenance of FAA...
  20. pmc Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans
    Erica D Smith
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    BMC Dev Biol 8:49. 2008
    ..Dietary restriction (DR) increases life span and delays age-associated disease in many organisms. The mechanism by which DR enhances longevity is not well understood...
  21. ncbi The functional costs and benefits of dietary restriction in Drosophila
    Joep M S Burger
    Department of Genetics, University of Georgia, Life Sciences Building, Athens, GA 30602 7223, USA
    Aging Cell 6:63-71. 2007
    ..Given the age-specific effects of DR on functional state, imposing DR late in life might not provide the same functional benefits as when applied at early ages...
  22. ncbi Effects of mild food deprivation on the estrous cycle of rats
    J Tropp
    Behavioral Neuroscience Division, Department of Psychology, University of Connecticut, Box U-20, 406 Babbidge Road, 06269, Storrs, CT, USA
    Physiol Behav 73:553-9. 2001
    It has long been known that severe food deprivation disrupts the estrous cycle. One of the main problems with behavioral tasks that use food for reinforcement is the requirement that the animal be food deprived...
  23. ncbi Analytical issues in the evaluation of food deprivation and sucrose concentration effects on the microstructure of licking behavior in the rat
    A C Spector
    Department of Psychology, University of Florida, Gainesville 32611 2250, USA
    Behav Neurosci 112:678-94. 1998
    ..03-1.0 M) in daily single-bottle, 1-hr sessions was conducted. Food deprivation and concentration interacted to increase total licks...
  24. ncbi Evidence of increased dopamine receptor signaling in food-restricted rats
    K D Carr
    Department of Psychiatry, Millhauser Laboratories, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Neuroscience 119:1157-67. 2003
    ..The signaling pathways mediating these augmented responses remain to be fully elucidated...
  25. ncbi Food deprivation alters osmoregulatory and metabolic responses to salinity acclimation in gilthead sea bream Sparus auratus
    Sergio Polakof
    Laboratorio de Fisioloxia Animal, Facultade de Ciencias do Mar, Edificio de Ciencias Experimentais, Universidade de Vigo, 36310, Vigo, Spain
    J Comp Physiol B 176:441-52. 2006
    ..b>Food deprivation abolished or attenuated the increase in gill Na+,K+-ATPase activity observed in LSW- and HSW-acclimated fish, ..
  26. ncbi Different colors reveal different information: how nutritional stress affects the expression of melanin- and structurally based ornamental plumage
    Kevin J McGraw
    Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    J Exp Biol 205:3747-55. 2002
  27. pmc Transcriptional feedback control of insulin receptor by dFOXO/FOXO1
    Oscar Puig
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Genes Dev 19:2435-46. 2005
    ..Our results reveal a key feedback control mechanism for dFOXO/FOXO1 in regulating metabolism and insulin signaling...
  28. pmc Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
    Hongying Yang
    Department of Pathology, Paul F Glenn Laboratories, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cell 130:1095-107. 2007
    ..We discuss the relevance of these findings to understanding how nutrition modulates physiology and to the evolution of apoptosis...
  29. ncbi Direct and trans-generational responses to food deprivation during development in the Glanville fritillary butterfly
    M Saastamoinen
    Department of Biosciences, University of Helsinki, Helsinki, Finland
    Oecologia 171:93-104. 2013
    ..We conducted a set of experiments to assess the direct and trans-generational effects of food deprivation in the Glanville fritillary butterfly Melitaea cinxia...
  30. pmc Effects of food deprivation on goal-directed behavior, spontaneous locomotion, and c-Fos immunoreactivity in the amygdala
    J M Moscarello
    Behavioral Pharmacology Laboratory, Department of Psychology, University of California, Santa Barbara, CA 93106 9660, USA
    Behav Brain Res 197:9-15. 2009
    Previous work in our laboratory has shown that food deprivation and food presentation produce different patterns of neuronal activity (as measured by c-Fos immunoreactivity) in the medial prefrontal cortex and nucleus accumbens of rats...
  31. pmc Dynamic interaction between medial prefrontal cortex and nucleus accumbens as a function of both motivational state and reinforcer magnitude: a c-Fos immunocytochemistry study
    Justin M Moscarello
    Behavioral Pharmacology Laboratory, Department of Psychology, University of California, Santa Barbara, CA 93106 9660, USA
    Brain Res 1169:69-76. 2007
    This study examined the effects of simultaneous variations in motivational state (food deprivation) and reinforcer magnitude (food presentation) on c-Fos immunoreactivity in the pre- and infralimbic medial prefrontal cortex (mPFC), ..
  32. pmc MTII attenuates ghrelin- and food deprivation-induced increases in food hoarding and food intake
    Erin Keen-Rhinehart
    Department of Biology and Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30302 4010, USA
    Horm Behav 52:612-20. 2007
    b>Food deprivation triggers a constellation of physiological and behavioral changes including increases in peripherally-produced ghrelin and centrally-produced agouti-related protein (AgRP)...
  33. ncbi Activation of the central nervous system in obese Zucker rats during food deprivation
    E Timofeeva
    , , , Canada, G1K 7P4
    J Comp Neurol 441:71-89. 2001
    ..out to investigate the pattern of neuronal activations that occur in the obese fa/fa Zucker rat during food deprivation. The functional activation of neurons was estimated in lean and obese Zucker rats either fed ad libitum or ..
  34. pmc Reintoxication: the release of fat-stored delta(9)-tetrahydrocannabinol (THC) into blood is enhanced by food deprivation or ACTH exposure
    N Gunasekaran
    School of Medical Science Pharmacology and Bosch Institute, The University of Sydney, Sydney, NSW, Australia
    Br J Pharmacol 158:1330-7. 2009
    ..Here we investigated whether conditions that promote lipolysis can liberate THC from adipocytes to yield increased blood levels of THC...
  35. pmc Enhanced food anticipatory activity associated with enhanced activation of extrahypothalamic neural pathways in serotonin2C receptor null mutant mice
    Jennifer L Hsu
    Gladstone Institute of Neurological Disease, San Francisco, California, United States of America
    PLoS ONE 5:e11802. 2010 5-HT2CR null mutant mice develops independent of external light cues and persists during two days of total food deprivation, indicating that food anticipatory activity in 5-HT2CR null mutant mice reflects the locomotor output of a ..
  36. pmc The Drosophila foraging gene mediates adult plasticity and gene-environment interactions in behaviour, metabolites, and gene expression in response to food deprivation
    Clement F Kent
    Department of Biology, University of Toronto Mississauga, Ontario, Canada
    PLoS Genet 5:e1000609. 2009
    ..Here we show that variants of the foraging (for) gene in Drosophila melanogaster affect the response to food deprivation in a large suite of adult phenotypes by measuring gene by environment interactions (GEI) in a suite of food-..
  37. ncbi A daily palatable meal without food deprivation entrains the suprachiasmatic nucleus of rats
    Jorge Mendoza
    Departamento de Anatomia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico DF, 04510, Mexico
    Eur J Neurosci 22:2855-62. 2005
    ..Here we evaluated the entrainment influence of a daily palatable meal, without regular food deprivation, on the circadian rhythm of locomotor activity and the c-Fos and PER-1 protein expression in the SCN...
  38. ncbi Enhanced food-anticipatory circadian rhythms in the genetically obese Zucker rat
    R E Mistlberger
    Department of Psychology, Simon Fraser University, Burnaby BC, Canada
    Physiol Behav 66:329-35. 1999
    ..Activity within this neuropeptide Y system is enhanced by food deprivation and attenuated by overfeeding and diet-induced obesity...
  39. ncbi Feeding cues alter clock gene oscillations and photic responses in the suprachiasmatic nuclei of mice exposed to a light/dark cycle
    Jorge Mendoza
    Laboratory of Neurobiology of Rhythms, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7518, Department of Neuroscience, Institut Fédératif de Recherche 37, University Louis Pasteur, F 67084 Strasbourg, France
    J Neurosci 25:1514-22. 2005
  40. ncbi After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance
    Nicole M Avena
    Department of Psychology, Princeton University, Princeton, NJ 08540, USA
    Physiol Behav 94:309-15. 2008
    ..This is similar to the effects of naloxone, suggesting opiate-like withdrawal. This may be a factor in some eating disorders...
  41. ncbi Molecular physiology of the neural circuit for calcineurin-dependent associative learning in Caenorhabditis elegans
    Atsushi Kuhara
    Division of Biological Science, Graduate School of Science and Institute for Advanced Research, Nagoya University, Nagoya 464 8602, Japan
    J Neurosci 26:9355-64. 2006
    ..Our results demonstrate the molecular and physiological mechanisms of a simple neural circuit for calcineurin-mediated associative learning behavior...
  42. ncbi Unpredictable feeding schedules unmask a system for daily resetting of behavioural and metabolic food entrainment
    Carolina Escobar
    Departamento de Anatomia, Edificio B 4 Piso, Facultad de Medicina, Circuito Escolar s n, Universidad Nacional Autonoma de Mexico, Mexico DF 04510, Mexico
    Eur J Neurosci 26:2804-14. 2007
    ..The variable feeding strategy uncovered a rapid (24-h basis) resetting mechanism for metabolism and general behaviour...
  43. ncbi Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex
    Emmanouil Karteris
    Biomedical Research Institute, Univ of Warwick, Gibbet Hill Rd, Coventry CV4 7AL, UK
    Am J Physiol Endocrinol Metab 288:E1089-100. 2005
    ..Given that orexins are involved in regulating food intake and activating the HPA axis, we hypothesized that food deprivation, an acute challenge to the systems that regulate energy balance, should elicit changes in orexin receptor ..
  44. ncbi Diet and aging
    Matthew D W Piper
    UCL Institute of Healthy Ageing, University College London, London, WC1E 6BT, UK
    Cell Metab 8:99-104. 2008
    ..Here we discuss examples of diet/genotype interactions that show a more complex mechanistic view is required and that mild dietary modifications can dramatically change the interpretation of model organism aging studies...
  45. ncbi Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway
    Tor Erik Rusten
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N 0310 Oslo
    Dev Cell 7:179-92. 2004
    ..Hence, these studies link hormonal induction of autophagy to the regulatory function of the PI3K signaling pathway in vivo...
  46. ncbi Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
    J C Erickson
    Howard Hughes Institute, University of Washington, Seattle, USA
    Nature 381:415-21. 1996 that mice deficient for NPY have normal food intake and body weight, and become hyperphagic following food deprivation. Mutant mice decrease their food intake and lose weight, initially to a greater extent than controls, when ..
  47. doi Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster
    Richard Wong
    Institute for Healthy Ageing, Darwin Building, University College London, Gower St, London, WC1E 6BT, UK
    Nat Methods 5:214-5; author reply 215. 2008
  48. pmc Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1
    Nora K McGhee
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Nutr 139:828-34. 2009
    b>Food deprivation induces a repression of protein synthesis in skeletal muscle in part due to reduced signaling through the mammalian target of rapamycin complex 1 (mTORC1)...
  49. ncbi Differential effects of a restricted feeding schedule on clock-gene expression in the hypothalamus of the rat
    M C Minana-Solis
    Departamento de Anatomia, Facultad de Medicina Universidad Nacional Autonoma de Mexico, Mexico, D F
    Chronobiol Int 26:808-20. 2009
    ..Present data highlight that metabolic or temporal cues elicited by feeding modify the temporal organization in the hypothalamus and are not exclusive for a food-entrained oscillator...
  50. pmc Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
    David B Lombard
    Howard Hughes Medical Institute, The Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 27:8807-14. 2007
    ..Overall, our results extend the recent finding of lysine acetylation of mitochondrial proteins and demonstrate that SIRT3 has evolved to control reversible lysine acetylation in this organelle...
  51. ncbi The role of corticosterone in food deprivation-induced reinstatement of cocaine seeking in the rat
    Uri Shalev
    Behavioral Neuroscience Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 168:170-6. 2003
    Acute 1-day food deprivation stress reinstates heroin seeking in rats, but the generality of this effect to other drugs, and its underlying mechanisms, are largely unknown...
  52. ncbi Two strategies for coping with food shortage in desert golden spiny mice
    Roee Gutman
    Department of Zoology, Tel Aviv University, Tel Aviv 69978, Israel
    Physiol Behav 90:95-102. 2007
    ..The use of two strategies to cope with food shortage as found in the golden spiny mice may be of evolutionary advantage, since it allows a more flexible reaction to food restriction at the population level...
  53. ncbi Immediate and delayed life history effects caused by food deprivation early in life in a short-lived lizard
    M Mugabo
    Centre National de la Recherche Scientifique UMR 7625, Laboratoire Ecologie et Evolution, UPMC ENS Université Pierre et Marie Curie, 7 quai St Bernard, Paris, France
    J Evol Biol 23:1886-98. 2010
    ..Using the common lizard (Zootoca vivipara), we tested whether a food deprivation during the two-first months of life influence life history (growth, survival, reproduction) and performance ..
  54. ncbi Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons
    Kanji A Takahashi
    Vollum Institute and The Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, Portland, Oregon 97239, USA
    Endocrinology 146:1043-7. 2005
    ..This is a remarkably straightforward example of a very robust in vitro electrophysiogical effect produced by a simple behavioral manipulation, food restriction...
  55. ncbi Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta have an attenuated response to cAMP and impaired carbohydrate metabolism
    C M Croniger
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 276:629-38. 2001
    ..C/EBP beta influences the regulation of carbohydrate metabolism by altering the level of hepatic cAMP and the activity of protein kinase A...
  56. ncbi Long-term dietary restriction causes negative effects on cognitive functions in rats
    Shuichi Yanai
    Department of Psychology, Doshisha University, Kyoto 602 8580, Japan
    Neurobiol Aging 25:325-32. 2004
  57. pmc Overnight food deprivation markedly attenuates hindbrain noradrenergic, glucagon-like peptide-1, and hypothalamic neural responses to exogenous cholecystokinin in male rats
    James W Maniscalco
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States
    Physiol Behav 121:35-42. 2013
    ..of A2, GLP-1, and mpPVN neurons would express cFos in rats after increasing doses of CCK, and that food deprivation would attenuate both hindbrain and hypothalamic neural activation...
  58. ncbi DAF-2 pathway mutations and food restriction in aging Caenorhabditis elegans differentially affect metabolism
    Koen Houthoofd
    Department of Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Neurobiol Aging 26:689-96. 2005
    ..In addition, we provide evidence that DAF-2 signaling controls mitochondrial bioenergetics by adjusting the rate of ATP synthesis to the rate of ATP utilization and by regulating the heat-producing proton leak pathway...
  59. ncbi Effects of diabetes and food deprivation on shivering activity during progressive hypothermia in the rat
    R D Kilgour
    Department of Exercise Science, Concordia University, Montreal, Quebec, Canada
    Comp Biochem Physiol A Physiol 114:159-65. 1996
    Diabetes mellitus and food deprivation are two conditions known to significantly reduce the ability to generate body heat during periods of acute cold stress...
  60. ncbi Larval life history responses to food deprivation in three species of predatory lady beetles (Coleoptera: Coccinellidae)
    Mpho W Phoofolo
    Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
    Environ Entomol 37:315-22. 2008
    ..axyridis and then C. maculata. Percentage weight loss of larvae was affected by food deprivation period and coccinellid species. Both C. maculata and H. axyridis lost significantly more weight than H...
  61. ncbi Endocrine responses to short-term feed deprivation in weanling pigs
    B E Salfen
    Animal Physiology Research Unit, ARS USDA, Columbia, Missouri, USA
    J Endocrinol 178:541-51. 2003
  62. ncbi Effects of food deprivation and refeeding on neuropeptide Y (NPY) mRNA levels in goldfish
    Y K Narnaware
    Department of Biological Sciences, University of Alberta, Alberta, T6G 2E9, Edmonton, Canada
    Comp Biochem Physiol B Biochem Mol Biol 129:633-7. 2001
    ..Taken together, these results further support that NPY is a physiological brain transducer involved in the regulation of daily appetite and feeding in goldfish...
  63. pmc CCAAT/enhancer binding protein-delta expression is increased in fast skeletal muscle by food deprivation and regulates myostatin transcription in vitro
    David L Allen
    Dept of Integrative Physiology, Univ of Colorado, Boulder, Campus Box 354, Boulder, CO 80309, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1592-601. 2010
    ..C/EBP-δ mRNA and protein levels were significantly increased by 2 days of food deprivation in the tibialis anterior (TA) muscle, and expression of both myostatin and C/EBP-δ mRNA during food ..
  64. ncbi Influence of long-term food restriction on sleep pattern in male rats
    Tathiana A F Alvarenga
    Department of Psychobiology, Universidade Federal de Sao Paulo, Rua Napoleao de Barros, 925, Vila Clementino SP 04024 002, Sao Paulo, Brazil
    Brain Res 1057:49-56. 2005
    ..These results suggest that dietary restriction, regardless to the feeding schedule, caused increase in total sleep time, during the active period...
  65. ncbi Effects of post-ovulatory food deprivation on the hormonal profiles, activity of the oviduct and ova transport in sows
    A M Mwanza
    Department of Obstetrics and Gynaecology, Centre for Reproductive Biology, Swedish University of Agricultural Sciences, Box 7039, SE 750 07, Uppsala, Sweden
    Anim Reprod Sci 59:185-99. 2000
    The objective of the present study was to investigate the effect of post-ovulatory food deprivation on the hormonal profiles and consequently on the activity of the oviduct and ova transport in sows...
  66. ncbi Selective fatty acid mobilization in the American mink (Mustela vison) during food deprivation
    Petteri Nieminen
    University of Joensuu, Department of Biology P O Box 111, FIN 80101, Joensuu, Finland
    Comp Biochem Physiol B Biochem Mol Biol 145:81-93. 2006
    The mobilization of fatty acids (FAs) during food deprivation is a selective process in laboratory rodents and humans. The site-specific differences in adipose tissue functions - e.g...
  67. ncbi Plasma concentrations of leptin mirror changes in body weight but do not influence the pattern of the preovulatory luteinizing hormone surge in mink (Mustela vison)
    Anne Helene Tauson
    Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Nutr 132:1790S-2S. 2002
  68. ncbi Effects of food deprivation on the development of Coleomegilla maculata (De Geer) (Coleoptera: Coccinellidae)
    T M Santos-Cividanes
    Agência Paulista de Tecnologia dos Agronegócios, Ribeirao Preto, SP, Brasil
    Neotrop Entomol 40:112-6. 2011
    ..0% and 23.4% for larvae fed every two and three days, respectively. Coleomegilla maculata showed fecundity of 781.1 ± 149.02, 563.4 ± 80.81 and 109.0 ± 103.0 eggs when fed daily and at intervals of two and three days, respectively...
  69. pmc Impact of postovulatory food deprivation on the ova transport, hormonal profiles and metabolic changes in sows
    P Razdan
    Department of Obstetrics and Gynaecology, Centre for Reproductive Biology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Acta Vet Scand 42:45-55. 2001
    The effect of food deprivation on ova transport, hormonal profiles and metabolic changes was studied in 20 crossbred multiparous sows during their second oestrus after weaning...
  70. ncbi Food insecurity, food choices, and body mass index in adults: nutrition transition in Trinidad and Tobago
    Martin C Gulliford
    Department of Public Health Sciences, King s College London, Nutrition and Metabolism Division, Ministry of Health, Laventille, Trinidad and Tobago
    Int J Epidemiol 32:508-16. 2003
    ..This study evaluated whether food insecurity and obesity were associated in a population sample in Trinidad...
  71. ncbi The arcuate NPY, POMC, and CART expressions responding to food deprivation are exaggerated in young female rats that experienced neonatal maternal separation
    S B Yoo
    Department of Oral and Maxillofacial Surgery, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea
    Neuropeptides 45:343-9. 2011
    ..and cocaine-amphetamine regulated transcript (CART) were examined at two months of age with or without food deprivation. The basal arcuate expression levels of these peptides did not differ between NH and MS group...
  72. ncbi Feeding induced by food deprivation is differentially reduced by G-protein alpha-subunit antisense probes in rats
    Maria M Hadjimarkou
    Department of Psychology and Neuropsychology Doctoral Sub Program, Queens College, City University of New York, 65 30 Kissena Blvd, Flushing, NY 11367, USA
    Brain Res 955:45-54. 2002
    ..The present study examined whether food intake and weight changes elicited by 24 h of food deprivation were significantly altered by ventricular administration of antisense probes directed against either G(i)..
  73. pmc The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker
    Michihiro Mieda
    Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Proc Natl Acad Sci U S A 103:12150-5. 2006
  74. ncbi Hungry for money: the desire for caloric resources increases the desire for financial resources and vice versa
    Barbara Briers
    HEC School of Management, Paris, France
    Psychol Sci 17:939-43. 2006
    ..In Study 3, participants' desire for money affected the amount of M&M's they ate in a subsequent taste test, but only among participants who were not restricting their food intake in order to manage their weight...
  75. ncbi Correcting the short-term effect of food deprivation in a damselfly: mechanisms and costs
    Melina Campero
    Laboratory of Aquatic Ecology, University of Leuven, Ch Deberiotstraat 32, B 3000 Leuven, Belgium
    J Anim Ecol 77:66-73. 2008
  76. pmc Gastrin-releasing peptide messenger ribonucleic acid expression in the hypothalamic paraventricular nucleus is altered by melanocortin receptor stimulation and food deprivation
    Ellen E Ladenheim
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Endocrinology 150:672-8. 2009
    ..we investigated whether GRP mRNA expression in the PVN may be sensitive to challenges imposed by either 38 h food deprivation or stimulation of the melanocortin system by the melanocortin 3/4 receptor agonist, melanotan II (MTII)...
  77. ncbi A metabolomics approach to elucidate effects of food deprivation in juvenile rainbow trout (Oncorhynchus mykiss)
    Andreas Kullgren
    Fish Endocrinology Laboratory, Dept of Zoology Zoophysiology, Univ of Gothenburg, Box 463, SE 405 30 Gothenburg, Sweden
    Am J Physiol Regul Integr Comp Physiol 299:R1440-8. 2010
    ..NMR-based metabolomics is a suitable method to generate an integrated view on metabolic processes during food deprivation in salmonid fish...
  78. ncbi Relationships of consumer characteristics and food deprivation to food purchasing behavior
    D J Mela
    Consumer Sciences Department, Institute of Food Research, Reading, UK
    Physiol Behav 60:1331-5. 1996
    ..behavior, and it is commonly believed that this may be significantly influenced by the shopper's state of food deprivation. In the present study, 198 subjects recruited just prior to shopping at a large supermarket completed ..
  79. ncbi Energy expenditure of rats subjected to long-term food restriction
    F N Santos-Pinto
    Disciplina de Fisiologia Renal e Termometabologia, Departamento de Fisiologia, , Rua Botucatu, 862, 5o andar, 04023-900 So Paulo, SP, Brazil
    Int J Food Sci Nutr 52:193-200. 2001
  80. ncbi Food deprivation increases post-heparin lipoprotein lipase activity in humans
    T Ruge
    Department of Medical Biosciences, , , Sweden
    Eur J Clin Invest 31:1040-7. 2001
    ..CONCLUSIONS: In animal models such as rats and guinea pigs, post-heparin LPL activity decreases on fasting, presumably due to down-regulation of adipose tissue LPL. In humans, fasting caused increased post-heparin LPL activity...
  81. ncbi Darker eumelanic barn owls better withstand food depletion through resistance to food deprivation and lower appetite
    Amelie Dreiss
    Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland
    Oecologia 164:65-71. 2010
    ..Eumelanic coloration may therefore be associated with adaptations to environments where the risk of food depletion is high...
  82. ncbi Housing conditions influence the expression of food-anticipatory activity in mice
    Marleen H M de Groot
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Physiol Behav 83:447-57. 2004
    ..g., those with different genotypes) should be interpreted cautiously, since at least one strain is strongly affected by a relatively minor procedural difference that was not anticipated to have a significant impact...
  83. ncbi Effects of acute food deprivation on eating behavior in eating disorders
    M M Hetherington
    Department of Psychology, University of Dundee, Dundee, Scotland
    Int J Eat Disord 28:272-83. 2000
    Effects of acute food deprivation on eating behavior in bulimic patients and controls were investigated. It was predicted that food deprivation would increase overall food intake and result in overeating in bulimics.
  84. ncbi A limited role for ghrelin in heroin self-administration and food deprivation-induced reinstatement of heroin seeking in rats
    Tia Maric
    Department of Psychology, Center for Studies in Behavioral Neurobiology, Group de Recherche en neurobiologie comportementale, Concordia University, Montreal, QC, Canada
    Addict Biol 17:613-22. 2012
    b>Food deprivation (FD) or restriction augments the locomotor activating and reinforcing effects of drugs of abuse...
  85. pmc Circadian clocks for all meal-times: anticipation of 2 daily meals in rats
    Ralph E Mistlberger
    Department of Psychology, Simon Fraser University, Burnaby, Canada
    PLoS ONE 7:e31772. 2012
    ..showed weak or no anticipation to one or both meals exhibited elevated activity at mealtime during 1 or 2 day food deprivation tests in DD, suggesting covert operation of circadian timing in the absence of anticipatory behavior...
  86. ncbi [Metabolic and endocrine effects of water and/or food deprivation in rats]
    Abir Grissa Kasdallah
    Laboratoire de Physiologie Animale, Departement de Biologie, faculté des sciences de Tunis El Manar, Campus Universitaire, 1060 Tunis, Tunisie
    C R Biol 328:463-70. 2005
    Metabolic and endocrine effects of water and/or food deprivation in rats...
  87. pmc Placental protection of the fetal brain during short-term food deprivation
    Kevin D Broad
    Sub Department of Animal Behaviour, University of Cambridge, Cambridge CB23 8AA, United Kingdom
    Proc Natl Acad Sci U S A 108:15237-41. 2011
    ..We further show that challenging this genomic linkage of hypothalamus and placenta with 24-h food deprivation results in disruption to coexpressed genes, primarily by affecting placental gene expression...
  88. ncbi Modulation of methylphenidate effects on wheel running and acoustic startle by acute food deprivation in commercially and selectively bred rats
    Ian B McLaughlin
    Department of Psychology, Occidental College, Los Angeles, CA 90041, USA
    Pharmacol Biochem Behav 97:500-8. 2011
    ..Modulation of the effects of methylphenidate (MPD) on wheel running and acoustic startle by food deprivation was examined in three experiments...
  89. ncbi Caloric restriction in primates and relevance to humans
    G S Roth
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Ann N Y Acad Sci 928:305-15. 2001
  90. ncbi Food deprivation induces adipose plasminogen activator inhibitor-1 (PAI-1) expression without accumulation of plasma PAI-1 in genetically obese and diabetic db/db mice
    Katsutaka Oishi
    Clock Cell Biology Research Group, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1, Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Thromb Haemost 98:864-70. 2007
    Relationships between energy intake and fibrinolytic functions have been documented in detail. We evaluated food deprivation (FD) as a means of modulating fibrinolytic activity in genetically obese and diabetic db/db mice and in their ..
  91. pmc AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G αo
    Catherine Hofler
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8024, USA
    J Neurosci 31:11553-62. 2011
    ..AGS-3 activates Gα(o) signaling in vivo to allow Caenorhabditis elegans to alter several behaviors after food deprivation, apparently so that the animals can more effectively seek food...
  92. ncbi Effect of food deprivation on the pulsatile LH release in the cycling and ovariectomized female rat
    F R Cagampang
    Laboratory of Animal Reproduction, School of Agriculture, Nagoya University, Japan
    Horm Metab Res 22:269-72. 1990
    The effect of food deprivation on the pulsatile release of LH was examined in the normal cycling and the ovariectomized (OVX) adult female rat...
  93. ncbi Effects of chronic food restriction and exercise training on the recovery of cardiac function following ischemia
    T L Broderick
    Department of Physiology, Midwestern University, Glendale, Arizona 85308, USA
    J Gerontol A Biol Sci Med Sci 56:B33-7. 2001
    ..Our results clearly indicate that the myocardium from the FR animal or the FR, exercise-trained rat is more resistant to ischemia...
  94. ncbi Prevention of adipose tissue depletion during food deprivation in angiotensin type 2 receptor-deficient mice
    Laurent Yvan-Charvet
    Institut National de la Sante et de la Recherche Medicale, Unité 671, 15 rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    Endocrinology 147:5078-86. 2006
    ..These data reveal an important physiological role of AT2R in metabolic adaptations to fasting...
  95. ncbi Lateral hypothalamic signaling mechanisms underlying feeding stimulation: differential contributions of Src family tyrosine kinases to feeding triggered either by NMDA injection or by food deprivation
    Arshad M Khan
    Department of Cell Biology and Neuroscience, University of California, Riverside, California 92521, USA
    J Neurosci 24:10603-15. 2004
    In rats, feeding can be triggered experimentally using many approaches. Included among these are (1) food deprivation and (2) acute microinjection of the neurotransmitter l-glutamate (Glu) or its receptor agonist NMDA into the lateral ..
  96. ncbi Interoceptive sensory signals produced by 24-hr food deprivation, pharmacological glucoprivation, and lipoprivation
    S C Benoit
    Department of Psychological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Behav Neurosci 110:168-80. 1996
    ..The present research was designed to assess if they also give rise to interoceptive cues like 24-hr food deprivation. Rats were first trained to discriminate a mild shock based on interoceptive cues arising from 1- and 24-hr ..
  97. ncbi Perinatal food deprivation induces marked alterations of the hypothalamo-pituitary-adrenal axis in 8-month-old male rats both under basal conditions and after a dehydration period
    Naima Sebaai
    Laboratoire de Neuroendocrinologie du Developpement, UPRES EA 2701, Universite de Lille 1, Villeneuve d Ascq, France
    Neuroendocrinology 79:163-73. 2004
    ..We speculate that higher basal HPA activity and an inadequate HPA response after dehydration in mature animals may contribute to diseases such as hypertension, known to develop with aging in perinatally growth-restricted rats...
  98. ncbi Dietary restriction in two rotifer species: the effect of the length of food deprivation on life span and reproduction
    Guntram Weithoff
    Institute for Biochemistry and Biology, University of Potsdam, Am Neuen Palais 10, 14469 Potsdam, Germany
    Oecologia 153:303-8. 2007
    ..These results suggest that in a temporally (or spatially) variable environment, some rotifer populations can persist even during long periods of severe food deprivation.
  99. ncbi Effects of food deprivation on host feeding and parasitism of whitefly parasitoids
    Lian Sheng Zang
    Texas AgriLife Research, Weslaco, TX 78596, USA
    Environ Entomol 39:912-8. 2010
    ..The effects of food deprivation on host-feeding and parasitizing capacity of the whitefly parasitoids Eretmocerus melanoscutus and Encarsia ..
  100. ncbi Peptidomics of Cpe fat/fat mouse hypothalamus: effect of food deprivation and exercise on peptide levels
    Fa Yun Che
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:4451-61. 2005
    ..Twenty-eight peptides were increased >50% by food deprivation, and some of these were increased by 2- to 3-fold...
  101. ncbi Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression
    Sheng Bi
    Dept of Psychiatry and Behavioral Sciences, Johns Hopkins Univ School of Medicine, 720 Rutland Ave, Ross 618, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1030-6. 2003
    Although acute food deprivation and chronic food restriction both result in body weight loss, they produce different metabolic states...

Research Grants62

  1. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..and nesfatin- 1/NUCB2 cellular expression, peptide modification and release into the circulation: a) 24 h food deprivation compared to ad libitum feeding and b) acute inflammation compared to healthy rats (peritoneal injection of ..
  2. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..First, a life-time of food deprivation and reduced body weight is not practical for most people;and, second, it has not been easy to identify the ..
  3. Ghrelin: Behavioral, Anatomical, and Physiological Components of Obesity
    BRETT JOHN WARREN TEUBNER; Fiscal Year: 2011
    ..the physiological range, increases ingestive behaviors in Siberian hamsters to nearly identical levels as food deprivation [36-56 hrs (IACUC approved), as shorter ones do not impact these behaviors due to their ample lipid stores]...
  4. The Role of Leptin in the Maintenance of a Reduced Body Weight
    Christos S Mantzoros; Fiscal Year: 2012
    ..Our group has shown that decreasing leptin levels mediate the neuroendocrine response to food deprivation in both animals and humans...
  5. Significance of Pituitary Leptin to Gonadotropes
    Gwen V Childs; Fiscal Year: 2010
    ..There are parallel reductions in pituitary leptin and LH during food deprivation and a parallel recovery mediated by glucose...
    Kirill M Popov; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The long-term regulation of PDHK activity is central to adaptation to food deprivation, hypoxia, high-fat diet, etc...
  7. Central Regulation of Hepatic Energy Stores
    Allison W Xu; Fiscal Year: 2013
    ..component of the overall adaptive regulation by leptin to ensure energy availability during long period of food deprivation. This mechanism may also operate in diet-induced obesity in that impairment of leptin signaling due to leptin ..
  8. Mechanisms of Oxidative Stress and Inflammation during Prolonged Fasting and Slee
    Rudy M Ortiz; Fiscal Year: 2013
    ..or alleviate the consequences of oxidative stress and inflammation commonly associated with protracted food deprivation and sleep apnea in humans in an effort to identify novel therapeutic targets...
  9. Effects of food deprivation on sexual behavior
    MICHAEL FERKIN; Fiscal Year: 2009
    ..The proposal is to use an animal model (the meadow vole) to examine the effects of food deprivation on three aspects of reproductive behavior (attractivity, proceptivity, and receptivity) as well as the ..
    IRWIN LEVITAN; Fiscal Year: 2009
    ..brain;and (4) mutant flies in which Slob expression is decreased exhibit locomotor rhythm defects and survive food deprivation much longer than their wild type counterparts...
  11. Neurocognitive Mechanisms of Decisions and Impulse Control in Nutrition Behavior
    Antoine Bechara; Fiscal Year: 2013
    ..We will also test the hypothesis that food deprivation induces an increased activation of the insular cortex with the consequence of exacerbating activity of the ..
    Marilyn Carroll; Fiscal Year: 2000
    ..Some groups of 5 rats will have behavioral interventions such as food satiation, food deprivation or access to an alternative reinforcer such as orally-delivered G+S or ethanol (8%)...
  13. Small RNAs: Regulation and Regulatory Activity in Body Weight Control
    Roderick V Jensen; Fiscal Year: 2010
    ..experiments will characterize a potentially new method for hypothalamic gene regulation during food intake, food deprivation or in obese individuals with high levels of circulating leptin...
  14. Promoter characterization of the CART gene
    Michael J Kuhar; Fiscal Year: 2010 has been shown that CART levels do change quickly (in hours) in response to cocaine and amphetamine and food deprivation, for example...
  15. Characterization of Taste-independent Sugar Sensor in the Brain
    Greg S B Suh; Fiscal Year: 2013
    ..still developed a preference for a sugar solution based on its nutritional value after prolonged periods of food deprivation. Specifically, these starved sugar-blind or taste-blind flies were able to distinguish nutritious D-glucose ..
    Michael Lewis; Fiscal Year: 1992
    ..Adult male Sprague Dawley rats will be studied. The induction of PCM will be achieved by prolonged food deprivation over 4 weeks. Emphysema will be induced by a single intratracheal installation of pancreatic porcine elastase...
  17. Developmental Control in C. elegans
    Min Han; Fiscal Year: 2013
    ..approach will further be used to identify dynamic miRNA::target interactions during animals'responses to food deprivation, pathogen infection and other stresses...
  18. Hypothalamic Type 2 Deiodinase in Metabolism Regulation
    Sabrina Diano; Fiscal Year: 2005
    ..leptin and elevating corticosterone levels that disrupts normal thyroid feedback during short-term food deprivation. The following Specific Aims will test our hypotheses: Specific Aim 1...
  19. A Novel Cytoprotective Peptide for GI Epithelial Cell
    FREDERICK TOBACK; Fiscal Year: 2005
    ..intracecal Pseudomonas aeruginosa following the surgical stress of partial hepatectomy and post-operative food deprivation in a model GDS...
  20. Genes underlying food-related behaviors in Drosphila.
    MARLA SOKOLOWSKI; Fiscal Year: 2007 the regulation of hunger and satiation: The normal behavioral response of a larva to an acute period of food deprivation is to increase its food intake and reduce its locomotor activity...
    Charles Billington; Fiscal Year: 2001
    ..activated by NPY in hypothalamic paraventricular nucleus, opioids in nucleus of the solitary tract, and by food deprivation through examining site specific expression of the immediate early gene, c-fos; (2) Verify the functional ..
    LAWRENCE MORIN; Fiscal Year: 1990
    Short photoperiod, prolonged cold exposure, lactation and food deprivation all produce anovulation in the female hamster...
    ERIC CORP; Fiscal Year: 2002
    ..the larger NPY neural circuitry, I propose additionally to investigate NPY gene expression in response to food deprivation in locus coeruleus and dorsal tegmental nuclei, two dorsal pontine loci with NPY efferent projections to ..
  24. Chronic stress intensifies incentive relativity
    Mary Dallman; Fiscal Year: 2006
    ..High B (and/or food deprivation) intensifies incentive relativity effects on a maze; and, 4...
    Dean Krahn; Fiscal Year: 1993
    ..Animal studies have suggested that increased drug intake may be caused by food deprivation. Because the onset of clinically significant eating disorders usually antedates the onset of clinically ..
  26. Homeostatic Substrates of Incentive Re-Valuation
    Norman Pecoraro; Fiscal Year: 2004
    ..Relativity effects will be exacerbated in a second set of animals by food deprivation. Radioimmunoassays and telemetry will determine whether 32% sucrose solutions entrain circadian feeding ..
    HENRY MARCUCELLA; Fiscal Year: 1980
    ..The concentration of ethanol and the subject state of food deprivation affect the amount of ethanol consumed, the duration of ethanol availability and non-availability periods ..
  28. The Effects of Sleep Deprivation on Cocaine Self-Administration and Relapse
    Matthew D Puhl; Fiscal Year: 2010
    ..Similarly, CORT has been shown to play a permissive role in relapse induced by food deprivation. Therefore, the plasma CORT response to the acute IV administration of cocaine will also be assessed ..
    ROBIN KANAREK; Fiscal Year: 1980
    ..effects of variables associated with food intake on narcotic administration, it has been recently shown that food deprivation leads to increased intakes of opioid solutions...
  30. Metabolic regulation of midbrain dopamine neurons
    Robert MacKenzie; Fiscal Year: 2005
    ..b>Food deprivation enhances feeding, drug self-administration, relapse to drug-taking and self-stimulation reward...
    MICHAEL TORDOFF; Fiscal Year: 2009
    ..g., food deprivation, water deprivation, temperature, motion)on adult phenotype...
  32. CRH Antagonists for Treatment of Drug Abuse
    James Woods; Fiscal Year: 2005
    ..v. administration of CRH, i.v. administration of the CRH R1 agonist EG12114, footshock, social defeat, and food deprivation. Initially, the effect of each stressor on ACTH and corticosterone levels will be determined...
    David Morgan; Fiscal Year: 1991
    ..of the increase in GFAP-RNA in these wasting mice will be sought by examining select aspects of the model; food deprivation, tumor transplantation, immune system reactivity and other conditions will be tested. Study IV: Intrinsic vs...
  34. Quantitative Peptidomics of Food Deprivation
    Lloyd Fricker; Fiscal Year: 2005
    ..of peptides in mouse hypothalamus, of which 20-30% are substantially up- or down-regulated by 2 days of food deprivation. In Aim 1, we will identify these peptides using tandem mass spectrometry...
    Frank Collins; Fiscal Year: 1991
    ..Research in behavioral pharmacology has indicated that drug reinforced behaviors increase during food deprivation. Specifically, animals that have been trained to self-administer drugs will show increased rates in self ..
    Dean Krahn; Fiscal Year: 1992
    ..Previous studies, including our own preliminary investigations, have shown that: (1) food deprivation causes significant changes in the self-administration of a variety of drugs (as well as changes in fat and ..
    Dzung Le; Fiscal Year: 1993
    ..differences in ethanol preference, 2) an examination into how behavioral manipulations such as stress and food deprivation, which have been shown to enhance ethanol consumption, might affect these three factors, and 3) an ..
    KENNETH CARR; Fiscal Year: 2006
    ..abstract_text> ..
  39. CNS Mechanisms that Modulate Reward
    KENNETH CARR; Fiscal Year: 2008
    ..The research proposed in this application is aimed at elucidating midbrain and striatal mechanisms involved in the increased behavioral responsiveness of FR rats to drugs of abuse. ..
  40. The Role of Melanocortin 4 Receptors in Energy Balance
    JULI JONES; Fiscal Year: 2005
  41. Matrix Metalloproteinases, Exercise, and Muscle Damage
    David Allen; Fiscal Year: 2008
    ..Finally, subjects will be genotyped for known functional MMP promoter polymorphisms, which will be correlated with MMP levels and muscle damage and soreness following eccentric exercise. ..
  42. Dorsomedial Hypothalamic Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2005
    ..Together, these neurochemical and functional demonstrations will provide a clear view of the role of the DMH in energy balance ..
  43. Dorsomedial Hypothalamic Signaling Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2010
    ..Overall, the elucidation of the actions of these DMH peptide systems in feeding and body weight control would significantly advance our understanding of the role of this hypothalamic nucleus in maintaining energy homeostasis. ..
  44. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
    ..Leibel and Dr. Wardlaw, are experienced in basic and clinical research. They are easily accessible, enthusiastic about my projects, and will facilitate my transition to status as an independent investigator. ..
  45. Leptin and Neuroendocrine Gene Regulation in Obesity
    Judith Korner; Fiscal Year: 2005
    ..abstract_text> ..
  46. TRH in mediating the bradycardia of caloric restriction
    Steven Swoap; Fiscal Year: 2005
    ..Resting and intrinsic HRs will be measured before and during a caloric restriction period. ..
  47. Cocaine Self Administration and Relapse in Mice:Gene del
    LAWRENCE MIDDAUGH; Fiscal Year: 2003
    ..These studies will significantly advance the use of the mouse species as a model for drug abuse and contribute toward establishing appropriate therapies for addiction. ..
    NORCROSS GEARY; Fiscal Year: 2003
    ..The work will be closely coordinated, and we expect this cooperative effort to be very productive. ..
    SUSAN SWITHERS; Fiscal Year: 2002
    ..e. food deprivation)...
  50. Physiology and genetics of food procurement in rodents
    Neil Rowland; Fiscal Year: 2008
    ..The proposed studies will be the first to address the issue of behavioral change induced by anorectics under such conditions of simulated economic costs. [unreadable] [unreadable] [unreadable]..
  51. Rapid Metabolic Control of the HPG System
    JILL SCHNEIDER; Fiscal Year: 2007
    ..Comparisons of species from two different taxa will test the generality of the conclusions. ..
    NORCROSS GEARY; Fiscal Year: 2008
    ..8) Determine the tonic and phasic effects of estradiol on glutamate synaptogenesis in the brainstem by using immunocytochemical detection of synaptic proteins. [unreadable] [unreadable]..
  53. Imprint Osmoregulation/Maternally-Dehydrated Offspring
    Mina Desai; Fiscal Year: 2007
    ..We will determine the molecular and cellular mechanism(s) and peripheral renal AVP receptor changes. Finally, we will delineate the critical period during which imprinting of the AVP/osmoregulatory pathway occurs. ..
    Dianne Lattemann; Fiscal Year: 2006
    ..non-diabetic rats. The results of these studies will provide new knowledge that ultimately may assist primary physicians in determining the most advantageous treatment for their diabetic patients with depression. ..
    Sarah F Leibowitz; Fiscal Year: 2010
    ..In summary, this grant tests the novel hypothesis that a high-fat diet itself can promote overeating and ultimately dietary obesity through a positive feedback loop involving circulating lipids, hypothalamic peptides and accumbens DA. ..
  56. Gender-Specific Ontogenic Cocaine Effects: Neuroanatomy
    Diana Dow Edwards; Fiscal Year: 2006
    ..Together these studies will examine the neuroanatomic basis for developmental cocaine's effects on function in males and females and determine the roles of gonadal steroids in producing these effects. ..
  57. Hindbrain integration of adiposity and satiety signals
    Diana Williams; Fiscal Year: 2007
    ..unreadable] [unreadable]..
    THOMAS SEYFRIED; Fiscal Year: 2009
    ..The proposed studies will provide essential information on combinatorial therapies for the ganglioside storage diseases and will have translational benefit to the clinic. ..
    THOMAS SEYFRIED; Fiscal Year: 2004
    ..Since there are no effective treatments for human ganglioside storages disease, the proposed research could offer a novel therapy for the early intervention of these neurodegenerative disorders. ..
  60. Nutritional Regulation of Fetal Liver Development
    PHILIP GRUPPUSO; Fiscal Year: 2008
    ..Furthermore, we anticipate that our findings will relate to diverse areas of liver biology, including the hepatic response to liver injury, hepatic carcinogenesis, and liver stem cell biology. [unreadable] [unreadable]..