Genomes and Genes
Summary: The ability to understand the nature and effect of the act in which the individual is engaged. (From Black's Law Dictionary, 6th ed).
Publications267 found, 100 shown here
- Are persons with cognitive impairment able to state consistent choices?L F Feinberg
Family Caregiver Alliance, San Francisco, CA 94104, USA
Gerontologist 41:374-82. 2001....
- Mental capacity to make decisions on treatment in people admitted to psychiatric hospitals: cross sectional studyGareth S Owen
Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London SE5 8AF
BMJ 337:a448. 2008..To estimate the prevalence of mental capacity to make decisions on treatment in people from different diagnostic and legal groups admitted to psychiatric hospital...
- Mental capacity and psychiatric in-patients: implications for the new mental health law in England and WalesGareth S Owen
Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London SE5 9RJ, UK
Br J Psychiatry 195:257-63. 2009..In England and Wales mental health services need to take account of the Mental Capacity Act 2005 and the Mental Health Act 1983. The overlap between these two causes dilemmas for clinicians...
- The challenges of clinical trials in the exclusion zone: the case of the frail elderlyIman Ridda
The Children Hospital, National Center for Immunisation Research and Surveillance, Westmead, New South Wales, Australia
Australas J Ageing 27:61-6. 2008....
- Depression and competence to refuse psychiatric treatmentA Rudnick
Department of Behavioral Sciences, Tel Aviv University School of Medicine, Israel
J Med Ethics 28:151-5. 2002..Further study of the relation between depression and competence to refuse or consent to psychiatric treatment is required...
- Assessing the competence of persons with Alzheimer's disease in providing informed consent for participation in researchS Y Kim
Department of Psychiatry and Division of Medical Humanities, University of Rochester School of Medicine and Dentistry, NY 14642, USA
Am J Psychiatry 158:712-7. 2001..A criterion validation study was carried out to help address this question...
- Prevalence and predictors of mental incapacity in psychiatric in-patientsRuth Cairns
Academic Department of Psychological Medicine, Institute of Psychiatry, Weston Education Centre, 10 Cutcombe Road, London SE5 9RJ, UK
Br J Psychiatry 187:379-85. 2005..Little is known about the proportion of psychiatric in-patients who lack capacity to make treatment decisions, or the associations of lack of capacity...
- Should children decide whether they are enrolled in nonbeneficial research?David Wendler
National Institutes of Health
Am J Bioeth 3:1-7. 2003..These principles imply that the threshold for assent should be fixed at 14 years of age, and a dissent requirement should be adopted for all children in the context of nonbeneficial research...
- Views of potential subjects toward proposed regulations for clinical research with adults unable to consentDave Wendler
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
Am J Psychiatry 159:585-91. 2002..The authors' goal was to assess healthy individuals' attitudes toward five of the most prominent proposed safeguards regarding the consent process for research with adults unable to consent...
- Current state of research on decision-making competence of cognitively impaired elderly personsScott Y H Kim
Department of Psychiatry, Division of Medical Humanities, University of Rochester School of Medicine, NY 14642, USA
Am J Geriatr Psychiatry 10:151-65. 2002..It is beginning to yield findings with practical implications for preserving the autonomy and welfare of this group of vulnerable elderly patients...
- Bariatric surgery for severely overweight adolescents: concerns and recommendationsThomas H Inge
Department of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
Pediatrics 114:217-23. 2004..Surgery should be performed in institutions that are equipped to meet the tertiary care needs of severely obese patients and to collect long-term data on the clinical outcomes of these patients...
- Assessment of the capacity to consent to treatment in patients admitted to acute medical wardsSylfa Fassassi
Service of Liaison Psychiatry, CHUV University Hospital, Lausanne, Switzerland
BMC Med Ethics 10:15. 2009....
- Unreasonable reasons: normative judgements in the assessment of mental capacityNatalie F Banner
Centre for the Humanities and Health, King s College London, London, UK
J Eval Clin Pract 18:1038-44. 2012..Rather, in recognizing this normativity, clinicians may better understand how clinical judgements are structured and what kinds of assumption may inform their assessment...
- Medical decision-making capacity in patients with mild cognitive impairmentO Okonkwo
Department of Neurology, JT 1216, University of Alabama at Birmingham, Birmingham, AL 35233 7340, USA
Neurology 69:1528-35. 2007..To empirically assess the capacity of patients with amnestic mild cognitive impairment (MCI) to consent to medical treatment under different consent standards (Ss)...
- Tales publicly allowed: competence, capacity, and religious beliefAdrienne M Martin
University of Pennsylvania Center for Bioethics, USA
Hastings Cent Rep 37:33-40. 2007..But that does not mean she is not competent...
- Functional mental capacity is not independent of the severity of psychosisEmer Rutledge
Central Mental Hospital, Dundrum, Dublin 14, Ireland
Int J Law Psychiatry 31:9-18. 2008..Function-specific mental capacities are the legal criteria for competence. These are regarded as superior to clinical assessments of mental state and general function...
- Effect of public deliberation on attitudes toward surrogate consent for dementia researchS Y H Kim
Center for Bioethics and Social Sciences in Medicine, University of Michigan, Ann Arbor 48109, USA
Neurology 77:2097-104. 2011..To assess the informed, deliberative views of the older general public toward a policy of allowing surrogate consent for Alzheimer disease (AD) research...
- Variability of judgments of capacity: experience of capacity evaluators in a study of research consent capacityScott Y H Kim
Center for Bioethics and Social Sciences in Medicine and Dept of Psychiatry, University of Michigan, 300 North Ingalls Street, Ann Arbor, MI 48109, USA
Psychosomatics 52:346-53. 2011..Assessment of decision-making capacity is a common and important function of psychiatric consultants. However, the sources of variability in evaluators' judgments have not been well characterized...
- Preservation of the capacity to appoint a proxy decision maker: implications for dementia researchScott Y H Kim
Center Bioethics and Social Sciences in Medicine, and Department of Psychiatry, University of Michigan, 300 N Ingalls St, 7C27, Ann Arbor, MI 48109, USA
Arch Gen Psychiatry 68:214-20. 2011..If individuals incapable of consenting to research studies were able to appoint a research proxy, it would allow for an appointed surrogate (rather than a de facto surrogate) to represent the subject...
- Report of an initial pilot study on the feasibility of using the MacArthur competence assessment tool for clinical research in children and adolescents with attention-deficit/hyperactivity disorderMichael Koelch
Department of Child and Adolescent Psychiatry Psychotherapy, University Hospital of Ulm, Ulm, Germany
J Child Adolesc Psychopharmacol 20:63-7. 2010..The aims were to test feasibility and to determine children's understanding of the elements of disclosure for a clinical drug trial and their competence to assent...
- Children's competence for assent and consent: a review of empirical findingsVictoria A Miller
Department of Psychology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 7123, USA
Ethics Behav 14:255-95. 2004....
- Competence of mentally ill patients: a comparative empirical studyJ Vollmann
Institute for History of Medicine and Medical Ethics, Friedrich Alexander University, Erlangen Nuremberg, Erlangen, Germany
Psychol Med 33:1463-71. 2003..The outcome of an objective test instrument is presented and compared with clinical assessment of competence by the attending physician...
- Older adults' participation in researchCynthia S Jacelon
School of Nursing, University of Massachusetts Amherst, USA
Nurse Res 14:64-73. 2007..Research with older adults involves unique challenges, says US-based researcher Cynthia S Jacelon, but it offers benefits to both researcher and subjects, providing negative stereotypes can be overcome...
- Surrogate consent for dementia research: a national survey of older AmericansS Y H Kim
Bioethics Program, University of Michigan, Ann Arbor, MI 48109, USA
Neurology 72:149-55. 2009..Because AD impairs decisional capacity, informed consent often must come from surrogates, usually close family members. But policies for surrogate consent for research remain unsettled after decades of debate...
- Speaking of research advance directives: planning for future research participationC B Stocking
MacLean Center for Clinical Medical Ethics, Department of Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA
Neurology 66:1361-6. 2006....
- Mental capacity, diagnosis and insight in psychiatric in-patients: a cross-sectional studyG S Owen
Departments of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, UK
Psychol Med 39:1389-98. 2009..Because it is a legal concept there is a need to clarify associations with variables that clinicians are more familiar with, especially insight...
- Reasoning in the capacity to make medical decisions: the consideration of valuesMichele J Karel
Mental Health Service, VA Boston Healthcare System, Boston, USA
J Clin Ethics 21:58-71. 2010..To examine the contribution of "values-based reasoning" in evaluating older adults' capacity to make medical decisions...
- Capacity to consent to treatment: empirical comparison of three instruments in older adults with and without dementiaJennifer Moye
Boston VA Healthcare System, Brockton VA Medical Center, 940 Belmont Street, Brockton, MA 02301, USA
Gerontologist 44:166-75. 2004..The purpose of this study was to compare adults with and without dementia on capacities to consent to treatment as assessed by three instruments...
- Mental health legislation and decision making capacity: capacity is more complex than it looksJacinta O A Tan
BMJ 332:119. 2006
- Magnitude of impairment in decisional capacity in people with schizophrenia compared to normal subjects: an overviewDilip V Jeste
Department of Psychiatry, University of California, San Diego, USA
Schizophr Bull 32:121-8. 2006....
- Assessment of capacity to consent to research among older persons with schizophrenia, Alzheimer disease, or diabetes mellitus: comparison of a 3-item questionnaire with a comprehensive standardized capacity instrumentBarton W Palmer
Department of Psychiatry, University of California, San Diego, USA
Arch Gen Psychiatry 62:726-33. 2005..Also, as requirements for formal assessment of decisional capacity are becoming more common, there is a clear need to identify efficient screening methods...
- Assessment of patient capacity to consent to treatmentE Etchells
Department of Medicine, The Toronto Hospital, University of Toronto, Toronto, Ont, Canada
J Gen Intern Med 14:27-34. 1999..Clinicians can use these practical, flexible, and evaluated measures as the initial step in the assessment of patient capacity to consent to treatment...
- Competence to refuse treatment in anorexia nervosaJacinta Tan
The Centre for Ethics and Communication Skills in Health Care Practice ETHOX, Division of Medicine, Institute of Health Sciences, University of Oxford, Old Road, Headington, Oxford OX3 7LF, England, UK
Int J Law Psychiatry 26:697-707. 2003
- Depression in the context of disability and the "right to die"Carol J Gill
Department of Disability and Human Development, University of Illinois at Chicago, 60608, USA
Theor Med Bioeth 25:171-98. 2004....
- Assessment of competence to complete advance directives: validation of a patient centred approachS Fazel
Section of Old Age Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX
BMJ 318:493-7. 1999..To develop a patient centred approach for the assessment of competence to complete advance directives ("living wills") of elderly people with cognitive impairment...
- Assessing mental capacity: the Mental Capacity ActTimothy R J Nicholson
Department of Psychological Medicine, Institute of Psychiatry, Western Education Centre, London
BMJ 336:322-5. 2008
- Assessing decisional capacity for clinical research or treatment: a review of instrumentsLaura B Dunn
Department of Psychiatry, 0603 V, University of California, San Diego, La Jolla, CA 92093 0603, USA
Am J Psychiatry 163:1323-34. 2006..The authors critically reviewed existing measures of decisional capacity for research and treatment...
- The assessment of mental capacityMatthew Hotopf
King s College London
Clin Med 5:580-4. 2005..This is contrasted with psychiatric inpatients, where the problem is no more frequent, but mainly relates to psychotic illness. The article finishes with some general guidance as to how to assess mental capacity in the general hospital...
- A direct comparison of research decision-making capacity: schizophrenia/schizoaffective, medically ill, and non-ill subjectsPhilip J Candilis
Law and Psychiatry Program, University of Massachusetts Medical School, Department of Psychiatry, Worcester, MA 01655, United States
Schizophr Res 99:350-8. 2008....
- Informed consent and the capacity for voluntarismLaura Weiss Roberts
Department of Psychiatry, University of New Mexico School of Medicine, Albequerque, 87131 5326, USA
Am J Psychiatry 159:705-12. 2002..Of these elements, voluntarism in clinical and research consent is the least well understood. This has interfered with the ability to resolve key ethical problems faced by the field of psychiatry...
- Mental disorder ethics: theory and empirical investigationN Eastman
Department of Mental Health, St George s University of London, Cramer Terrace, London
J Med Ethics 32:94-9. 2006..wellcome.ac.uk/doc.WTX025116.html...
- Prevalence of mental incapacity in medical inpatients and associated risk factors: cross-sectional studyVanessa Raymont
Institute of Psychiatry, King s College London, UK
Lancet 364:1421-7. 2004....
- Balancing autonomy and risk: a failure of nerve in England and Wales?Genevra Richardson
School of Law, King s College London, Strand, London WC2R 2LS, United Kingdom
Int J Law Psychiatry 30:71-80. 2007..The relationship between mental health and mental capacity, or guardianship, legislation is then considered and possible ways forward are discussed with particular reference to the current reform debate in England and Wales...
- Using drugs to end life without an explicit request of the patientJudith A C Rietjens
Erasmus MC, University Medical Center Rotterdam, Department of Public Health, Erasmus MC, P O Box 2040, 3000CA Rotterdam, The Netherlands
Death Stud 31:205-21. 2007..The use of drugs with the intention to hasten death without an explicit request of the patient is part of medical end-of-life practice in the studied countries, regardless of their legal framework, and it occurs in similar fashion...
- Ten myths about decision-making capacityLinda Ganzini
Department of Psychiatry, Oregon Health and Science University and Portland Veterans Affairs Medical Center, Portland, OR, USA
J Am Med Dir Assoc 6:S100-4. 2005....
- The psychology of competence and informed consent: understanding decision-making with regard to clinical practiceBarry Rosenfeld
Department of Psychology, Fordham University, NY, USA
Fordham Urban Law J 30:173-85. 2002
- Patients' competence to consent to treatmentJeffrey P Spike
N Engl J Med 358:644; author reply 644. 2008
- Faulty judgment, expert opinion, and decision-making capacityM Silberfeld
Competency Clinic, Baycrest Centre for Geriatric Care, North York, ON, Canada
Theor Med Bioeth 20:377-93. 1999..We propose the requisite expertise to be developed in the long term as a distinct multidisciplinary endeavour...
- Children, Gillick competency and consent for involvement in researchD Hunter
School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA
J Med Ethics 33:659-62. 2007..In both cases, to ensure that autonomy is genuinely respected and to protect against personal interest, Gillick competency should be assessed by an individual who has no interest or involvement in the research...
- Clinical practice. Assessment of patients' competence to consent to treatmentPaul S Appelbaum
Division of Law, Ethics, and Psychiatry, Department of Psychiatry, College of Physicians and Surgeons, Columbia University and New York State Psychiatric Institute, New York 10032, USA
N Engl J Med 357:1834-40. 2007
- Reliability of mental capacity assessments in psychiatric in-patientsRuth Cairns
Academic Department of Psychological Medicine, Institute of Psychiatry, Weston Education Centre, 10 Cutcombe Road, London SE5 9RJ, UK
Br J Psychiatry 187:372-8. 2005..Previous work on the reliability of mental capacity assessments in patients with psychiatric illness has been limited...
- Informed consent/assent in children. Statement of the Ethics Working Group of the Confederation of European Specialists in Paediatrics (CESP)Maria De Lourdes Levy
University Clinic of Pediatrics, Hospital de Santa Maria, Lisbon, Portugal
Eur J Pediatr 162:629-33. 2003..However, parents may also refuse to consent and in this case national laws and legal mechanisms for resolving disputes may be used...
- Extra information about treatment is too much for the patient with psychosisMiriam Kennedy
Central Mental Hospital, Dublin, Ireland
Int J Law Psychiatry 32:369-76. 2009..Case law across jurisdictions requires ever more complete disclosure of material facts when obtaining consent to treatment...
- Clinical ethics issues in geriatric psychiatryArt Walaszek
Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, 6001 Research Park Boulevard, Madison, WI 53719, USA
Psychiatr Clin North Am 32:343-59. 2009..Psychiatrists must be vigilant that the mental health needs of older adults, including access to effective therapies, are addressed adequately in such discussions...
- Assessing the capacity to make everyday decisions: a guide for clinicians and an agenda for future researchJames M Lai
Department of Medicine, Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine, New Haven, CT 06504, USA
Am J Geriatr Psychiatry 15:101-11. 2007..Future research should develop and validate methods to identify patients with impaired capacity to make everyday decisions. These data will supplement functional, cognitive, and medical assessments...
- Factors associated with experts' opinions regarding criminal responsibility in The NetherlandsMarko Barendregt
yNetherlands Institute of Forensic Psychiatry and Psychology, Location Pieter Baan Centre, Utrecht, The Netherlands
Behav Sci Law 26:619-31. 2008....
- The California Scale of Appreciation: a new instrument to measure the appreciation component of capacity to consent to researchElyn R Saks
The Law School, University of Southern California, Los Angeles, CA 90089 0071, USA
Am J Geriatr Psychiatry 10:166-74. 2002..Its generalizability to other patient populations and to other types of protocols needs to be determined...
- When does decisional impairment become decisional incompetence? Ethical and methodological issues in capacity research in schizophreniaScott Y H Kim
Department of Psychiatry, University of Michigan, 300 North Ingalls Street, 7C27, Ann Arbor, MI 48109, USA
Schizophr Bull 32:92-7. 2006..Future research needs are outlined...
- The contribution of narrative ethics to issues of capacity in psychiatryRoger Higgs
Department of General Practice and Primary Care, King s College, London, SE 11 6SP, United Kingdom
Health Care Anal 12:307-16; discussion 265-72. 2004..The narrative approach should be used to try to make different stories compatible. This article examines the background to this approach, and indicates some ways in which it could be used in the specific cases addressed in the series...
- The cognitive based approach of capacity assessment in psychiatry: a philosophical critique of the MacCAT-TTorsten Marcus Breden
Institut fur Geschichte und Ethik der Medizin, Friedrich Alexander Universitat Erlangen Nurnberg, Glückstrasse 10, Erlangen, Germany
Health Care Anal 12:273-83; discussion 265-72. 2004..In conclusion some main demands for further research to develop a multi-step model of competence assessment are outlined...
- The MacArthur Competence Assessment Tool-Fitness to Plead: a preliminary evaluation of a research instrument for assessing fitness to plead in England and WalesAkintunde A Akinkunmi
Camlet Lodge Regional Secure Unit, Chase Farm Hospital, Enfield, UK
J Am Acad Psychiatry Law 30:476-82. 2002..The instrument was able to detect significant differences in scores over time. It is suggested that once the instrument has been further validated for research purposes, it may be developed for clinical application...
- Free will: reconciling German civil law with Libet's neurophysiological studies on the readiness potentialWolfram Kawohl
Psychiatric University Hospital, Lenggstrasse 31, 8032 Zurich, Switzerland
Behav Sci Law 25:309-20. 2007..Therefore, advice for the psychiatrist as an expert witness is offered on the basis of a psychopathological approach that takes into account cognitive and motivational preconditions and the structure of values and personality...
- How the public responded to the Schiavo controversy: evidence from letters to editorsEric Racine
Neuroethics Research Unit, Office 1535, IRCM, 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada
J Med Ethics 36:571-3. 2010..Distinct public discourses can be encountered in different stakeholders suggesting complex and extensive pluralism even within the media...
- How should paediatricians assess Gillick competence?Vic Larcher
Consultant in Paediatrics and Clinical Ethics, Great Ormond Street Hospital NHS Trust, Great Ormond Street, London WC1N 3JH, UK
Arch Dis Child 95:307-11. 2010..In rare cases courts may be involved...
- Informed consent: are we deluding ourselves? A randomized controlled studyJunaid Masood
Department of Urology, Harold Wood Hospital, Romford, Essex, UK
BJU Int 99:4-5. 2007
- Mental capacity in psychiatric patients: Systematic reviewDavid Okai
Department of Psychological Medicine, Institute of Psychiatry, Weston Education Centre, 10 Cutcombe Road, London SE5 9RJ, UK
Br J Psychiatry 191:291-7. 2007..Mental capacity is central to legal and ethical debates on the use of compulsion in psychiatry...
- Recruitment of frail older people to research: lessons learnt through experienceR Harris
Florence Nightingale School of Nursing and Midwifery, King s College, James Clerk Maxwell Building, 57 Waterloo Road, London SE1 8WA, UK
J Adv Nurs 36:643-51. 2001..Difficulty in the recruitment of older people to research is widely acknowledged. However, much can be achieved to maximize the success of this process...
- Capacity for decision-making in Alzheimer's disease: selfhood, positioning and semiotic peopleSteven R Sabat
Department of Psychology, Georgetown University, Washington, District of Columbia 20057, USA
Aust N Z J Psychiatry 39:1030-5. 2005....
- 'Refusing treatment--please see': an analysis of capacity assessments carried out by a liaison psychiatry serviceGopinath Ranjith
Department of Psychological Medicine, King s College Hospital, London, UK
J R Soc Med 97:480-2. 2004..Liaison psychiatric services can be useful not only in offering a second opinion or clarifying the influence of psychopathology on decision-making ability but also mediating between the patient and the clinical team...
- Who decides--the patient, the physician or the rabbi?Shimon M Glick
Lord Rabbi Immanuel Jakobovits Center for Jewish Medical Ethics, Faculty of Health Sciences, Ben Gurion University, Israel
Assia Jew Med Ethics 4:20-30. 2004
- The not unreasonable standard for assessment of surrogates and surrogate decisionsRosamond Rhodes
Department of Medical Education, Mount Sinai School of Medicine, New York, NY 10029, USA
Theor Med Bioeth 25:367-85. 2004..This paper provides a model for acceptable surrogate decisions and a standard for blocking inappropriate surrogates. Only decisions based on widely shared reasons are allowable for surrogate refusal of highly beneficial treatment...
- Treating competent patients by force: the limits and lessons of Israel's Patient's Rights ActM L Gross
Department of Political Science, University of Haifa, Israel
J Med Ethics 31:29-34. 2005..These concerns reach past Israel and should engage healthcare professionals wary that respect for autonomy may sometimes cause avoidable harm...
- Children and research participation: who makes what decisionsChristy Simpson
Department of Bioethics, Dalhousie University, Halifax, Nova Scotia, Canada
Health Law Rev 11:20-9. 2003
- Strategies for enhancing the nurse's role in assessing and promoting a patient's decisional capacityMarcia Sue DeWolf Bosek
Department of Adult Health Nursing and Program in Ethics and Department of Religion, Health and Human Values, Rush University, Chicago, IL, USA
JONAS Healthc Law Ethics Regul 7:75-8. 2005
- Ongoing consent to care for older people in care homesCathy Butterworth
Commission for Social Care Inspection, Taunton
Nurs Stand 19:40-5. 2005....
- A goodness-of-fit ethic for informed consentCelia B Fisher
Graduate Faculty, New School for Social Research, NY, USA
Fordham Urban Law J 30:159-71. 2002
- Advance decisions to refuse treatment component of the Mental Capacity ActCarolyn Bennett
Sherwood Forest Hospitals NHS Foundation Trust, King s Mill Hospital
Br J Nurs 17:885-8. 2008..Advance care planning is a significant component of the recently published End-of-Life Care Strategy...
- Assisted and surrogate decision making for pregnant patients who have schizophreniaJohn H Coverdale
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Schizophr Bull 30:659-64. 2004..These strategies should substantially enhance patients' autonomy in the psychiatrist-patient relationship and contribute to the quality of their psychiatric and obstetric care...
- Taking resuscitation decisions in the nursing home settingAndrew Makin
Registered Nursing Home Association
Nurs Times 101:28-30. 2005..The way decisions about resuscitation are made in A&E departments is not the same as in nursing homes for older people. This article discusses prompt appropriate decision-making regarding resuscitation in the nursing home setting...
- How to justify enforcing a Ulysses contract when Ulysses is competent to refuseJohn K Davis
California State University, Fullerton, USA
Kennedy Inst Ethics J 18:87-106. 2008..Mental health directives accomplish this, so they are a way of respecting the agent's autonomy even when providers override the agent's current competent refusal...
- The Mental Capacity Act 2005 and decision-making: advance decisionsBridgit Dimond
University of Glamorgan, Wales
Br J Nurs 17:44-6. 2008..The link between advance decisions are lasting powers of attorney is also discussed...
- Advance directives, future selves and decision-makingAlasdair R MacLean
University of Dundee
Med Law Rev 14:291-320. 2006
- Listening to the disabled: end-of-life medical decision making and the never competentEric C Miller
Fordham Law Rev 74:2889-925. 2006
- A comprehensive primer of surgical informed consentJames W Jones
Surg Clin North Am 87:903-18, viii. 2007....
- Competency for creation, use, and revocation of psychiatric advance directivesDebra S Srebnik
Department of Psychiatry and Behavioral Sciences, University of Washington, Box 359911, 325 Ninth Avenue, Seattle, WA 98104, USA
J Am Acad Psychiatry Law 34:501-10. 2006..As more directives are created and used, additional research and statutory refinements are warranted...
- Dementia and the lawSjef Gevers
Academic Medical Center, University of Amsterdam
Eur J Health Law 13:209-17. 2006..This article explores some of the more important topics, i.e. (early) diagnosis of the disease, the availability and provision of care, treatment and non treatment decisions, and medical research with dementia patients...
- Medical research on patients with dementia--the role of advance directives in European legal instrumentsSalla Lotjonen
The University of Manchester, United Kingdom
Eur J Health Law 13:235-61. 2006..This article examines the provisions in these documents and their national applications in Finland and the United Kingdom...
- Best interests. An holistic approach: Part 2(b)Suzanne Fullbrook
Nursing Law and Politics, Faculty of Health, London South Bank University, UK
Br J Nurs 16:746-7. 2007..The situation of enforced treatment and care is a delicate one. Staff have to be aware of the legal principles that apply, with reference to the Mental Capacity Act...
- Best interests: a review of issues that affect nurses' decision makingSuzanne Fullbrook
Nursing Law and Politics, Faculty of Health, London South Bank University, UK
Br J Nurs 16:600-1. 2007....
- What do people at risk for Alzheimer disease think about surrogate consent for research?Dale B Schenk
Neurology 66:1785-6. 2006
- Health care decision-making capacity: a legal perspective for long-term care providersStuart D Zimring
Law Offices of Stuart D Zimring, North Hollywood, CA 91607, USA
J Am Med Dir Assoc 7:322-6. 2006..Sensitivity to multicultural diversity in this context is imperative to maintain individual self-esteem and respect, both for the patient and the patient's family...
- Making decisions for incapable adults. 2: Advanced decisions refusing careRichard Griffith
School of Health Science, Swansea University
Br J Community Nurs 11:162-6. 2006..For the first time in England and Wales a person will be able to appoint another to make consent-to-treatment decisions on their behalf that will be binding on district nurses and other health professionals...
- Whose body is it anyway? An updated model of healthcare decision-making rights for adolescentsKimberly M Mutcherson
Rutgers School of Law Camden, USA
Cornell J Law Public Policy 14:251-325. 2005
- Ethics and law in the intensive care unitC M Danbury
Intensive Care Unit, Royal Berkshire Hospital, London Road, Reading, RGI 5AN, UK
Best Pract Res Clin Anaesthesiol 20:589-603. 2006..We examine some recent cases and discuss the impact that these cases may have on practice in Intensive Care...
- Mental health legislation should respect decision making capacityLen Doyal
Barts and the London School of Medicine and Dentistry, Queen Mary College, University of London, London E1 2AD
BMJ 331:1467-9. 2005
- Control and compulsory treatment in anorexia nervosa: the views of patients and parentsJacinta O A Tan
Centre for Ethics and Communication Skills in Health Care Practice ETHOX, Institute of Health Sciences, Division of Medicine, University of Oxford, Old Road, Headington, Oxford, Oxfordshire OX3 7LF, England, UK
Int J Law Psychiatry 26:627-45. 2003
- Mental capacity and decision making: defining capacityBridgit Dimond
University of Glamorgan, Wales
Br J Nurs 16:1138-9. 2007..This first article looks at the central feature of the Act: how mental capacity is determined...
- Clinical research with cognitively impaired subjects: issues for nursesJennifer Lanter
Department of Internal Medicine, Division of Digestive Health, Ohio State University, 274A Doan Hall, 410 West 10th Avenue, Columbus, OH 43210, USA
Dimens Crit Care Nurs 25:89-92. 2006..This article provides insight into the ethical principles in clinical research as they pertain to subjects who may have diminished ability to make their own decisions...
- Questioning our principles: anthropological contributions to ethical dilemmas in clinical practiceCarolyn Sargent
Department of Anthropology, Southern Methodist University, Dallas, Texas, USA
Camb Q Healthc Ethics 15:123-34. 2006
- Cardiopulmonary resuscitation: nurses and the lawJ Wood
Faculty of Health and Social Care Sciences, Kingston University and St George s, University of London, London
Nurs Stand 22:35-40. 2007..This article updates nurses on the laws governing cardiopulmonary resuscitation in relation to patients who have capacity at the time of admission to hospital, and promotes thoughtful ethical practice...
- End-of-life patients, intensive care and consent: difficulties facing French intensivistsN Franchitto
Rangueil University Hospital, Department of Anesthesiology and Intensive Care, Toulouse, France
Eur J Anaesthesiol 24:709-13. 2007..The French legislature passed a law in 2005 that assigns a new role to the physician and redefines his liability in end-of-life decisions...
- Systematics of medically important Dermacentor tick vectorsDmitry A Apanaskevich; Fiscal Year: 2011....
- OLIGOCLONAL T CELL EXPANSION AND RHEUMATOID ARTHRITISCornelia M Weyand; Fiscal Year: 2012..The studies will include vaccinating RA patients with an influenza vaccine to test whether they can build sufficient T cells to be protected from infection. ..
- Integrating stress MAP kinase signaling with DNA replication origin licensingJeanette Gowen Cook; Fiscal Year: 2013....
- Cooperative Multicenter Reproductive Medicine Network (U10)MARCELLE IVONNE CEDARS; Fiscal Year: 2013..In this proposal, drawing from studies of somatic aging, we propose a novel treatment to improve mitochondrial function and potentially reverse the age- associated decline in fertility...
- Mitochondrial function and antifungal photodynamic therapyConstantine G Haidaris; Fiscal Year: 2011..abstract_text> ..
- Pbx Homeodomain Proteins in Skeletal Muscle DifferentiationLISA A MAVES; Fiscal Year: 2011..Understanding these mechanisms ultimately may be useful in improving the ability to control muscle precursor differentiation and, therefore, relevant to developing therapies for treating musculoskeletal diseases. ..
- Investigating the role of interleukin-22 in thymus functionJarrod Dudakov; Fiscal Year: 2013....
- IL-22 in Thymic RegenerationMarcel R m van den Brink; Fiscal Year: 2013....
- Chronic ethanol, B cell competence and lymphoid integrityThomas J Waldschmidt; Fiscal Year: 2010..Consortium/Contractual Arrangements N/A 10. Consultants/Collaborators 274 11. Letters of Support 275-278 Appendices on CD: 1 Copy of Figures and 4 Publications PHS 398 (Rev. 04/06) Page 242 Form Page 3 ..
- Screen for Small Molecule Regulators of Retinal Progenitor Epithelial Cell PhagocCHARLES YOON HYUNG CHO; Fiscal Year: 2010..This proposal seeks to develop new assay technology that could test several hundred thousand compounds to speed the development of new treatments for this devastating disease. ..
- Insulin, IGF and Insulin Signaling: effects on Anopheles lifespan and immunityMICHAEL ALLEN RIEHLE; Fiscal Year: 2012..We hope to enhance innate immunity and/or reduce average lifespan of a model mosquito below this development period so that transmission of malaria parasites is reduced or eliminated. ..
- Self-Determination Theory and Lifestyle Behaviors in Barrett's Esophagus PatientsHODA J BADR; Fiscal Year: 2010..Thus, the proposed project involves a relatively small investment that could yield great progress in understanding the health promotion needs of this understudied population. ..
- Feasibility and Preliminary Efficacy of Yoga in Head and Neck Cancer SurvivorsSheila H Ridner; Fiscal Year: 2013..If our aims are achieved, in the future we will explore a web and/or community based Yoga intervention for HNC survivors. ..
- Using Mixed Reality to build peer resistance skills in Latina middle schoolersANNE E contact NORRIS; Fiscal Year: 2010..Study results will also be helpful to other researchers developing technology based health games designed to promote health. ..
- Perinatal Stress and programming of childhood wheeze and lung functionRosalind J Wright; Fiscal Year: 2013..Knowledge gained from the proposed research may inform new pathways linking stress to lung structure-function changes. ..
- The Significance of Leptin Signals to Neonatal Somatotropes and GonadotropesGwen V Childs; Fiscal Year: 2013..This proposal thus addresses important questions about how leptin can affect reproductive competence at the level of the pituitary. ..
- P. papatasi midgut molecules: gene function and assessing TBV candidatesJOSE MARCELO contact RAMALHO ORTIGAO; Fiscal Year: 2010....
- Role of Fetal Steroids in Formation and Activation of Bovine Ovarian FolliclesJoanne E Fortune; Fiscal Year: 2010..We propose to use cattle as an animal model to test the hypothesis that steroids made by the fetal ovary play a role in regulating these earliest stages of ovarian follicular development. ..
- Control of developmental timing and body size in DrosophilaMICHAEL BRENDAN O'CONNOR; Fiscal Year: 2013....
- Integrated MRI-Based Examination for Evaluation of Peripheral Arterial DiseaseFelix W Wehrli; Fiscal Year: 2010....
- The effect of inter-species interactions on the virulence of Streptococcus mutansBing yan Wang; Fiscal Year: 2009..The S. mutans quorum-sensing system may be an appropriate target for interruption to reduce dental caries. The disruption of CSP-dependent regulation has the potential to attenuate the bacterium so that it is less virulent. ..
- Project LOVE: Preventing Adolescent Dating Violence among Rural African AmericansDionne Smith Coker-Appiah; Fiscal Year: 2013....
- Role of complement in alpha-synuclein based models of Parkinson diseaseHEATHER ELIZABETH ALLEN; Fiscal Year: 2013..This proposal aims to provide evidence for a role for the complement system in PD pathology. This study would serve as rationale for the complement system as an innovative target for the development of PD therapies and biomarkers. ..
- Mitochondrial Gene TherapyShoukhrat M Mitalipov; Fiscal Year: 2013..In this study, we will explore feasibility, efficiency and safety of this novel mitochondrial gene replacement therapy in a clinically relevant nonhuman primate model. ..
- Hampton University Skin of Color Research Institute Skin of Color Symposium 2011:Meena Katdare; Fiscal Year: 2011....
- Connexin 43 in Bone RemodelingRoberto Civitelli; Fiscal Year: 2013..Results will establish the mechanisms by which Cx43 modulates cortical bone and how such mechanisms cause the skeletal abnormalities of ODDD, findings that may be translated to clinical settings and lead to pharmacologic targeting. ..
- Coordinate regulation of competence and pneumocin production in S. pneumoniaeSUZANNE RACHEL DAWID; Fiscal Year: 2013..Understanding how the variably expressed pneumocins contribute to this diversity will allow us to better anticipate and perhaps block attempts at escape from control measures via genetic exchange. ..
- MOLECULAR MANIPULATION TO ENHANCE ANTI-MYELOMA RESPONSENikhil C Munshi; Fiscal Year: 2013..The proposed studies will identify the mechanism of immune suppression in myeloma, develop methods to improve immune function and develop peptide-based vaccination strategies to preclinical rational for their clinical application. ..
- Dorsal Column Stimulation as a New Therapy for Motor DisordersMiguel A L Nicolelis; Fiscal Year: 2013..abstract_text> ..
- Flexibility and Commitment in Post-Effector Cd4 LymphocytesMark R Boothby; Fiscal Year: 2013....
- Furlow Palatoplasty with Tensor Tenopexy for Otitis MediaJoseph E Losee; Fiscal Year: 2013..abstract_text> ..
- High Resolution Peripheral Quantitative CTMARY BETH LEONARD; Fiscal Year: 2013..We have a detailed and ready-to-execute plan for operation that includes technical expertise and support, and full institutional commitment. ..
- Physiological Mechanisms Underlying Heightened Responsiveness of Gonadotropes toColin M Clay; Fiscal Year: 2013....
- Control of NF-kappaB ActivityALBERT SIDNEY BALDWIN; Fiscal Year: 2013..abstract_text> ..
- VICTORY-Virtual Video Game Therapy for Substance Cessation and RecoveryB Eugene Parker; Fiscal Year: 2013..The proposed VICTORY system will use the proven models of self-determination theory and cue/reaction therapy to create a low-cost video game therapy approach for nicotine abuse treatment. ..
- Fatal Choice - Behavioral Economics of Vulnerability for Late-Life SuicideKATALIN NONE SZANTO; Fiscal Year: 2011..Applying behavioral economics theory and methods to the study of suicide, the proposed research program offers an experimental approach to understanding the dynamics of the suicidal crisis and may lead to novel preventive interventions. ..
- PETS-D: Parent Education Through Simulation-DiabetesSusan Sullivan-Bolyai; Fiscal Year: 2013..School-aged children and adolescents could also be instructed in self-management with this type of enhanced educational strategy. ..
- Genetic and Biochemical Analysis of DNA Exchange in Helicobacter pyloriMARION SHONN DORER; Fiscal Year: 2010..Studying the bacterium will help us develop new drugs that will rid people of the infection and reduce greatly their risk of developing ulcers or stomach cancer. ..
- Tsetse Transmitted African TrypanosomiasisSerap Aksoy; Fiscal Year: 2013..4) Develop a community of researchers/mentors in DECs with strong knowledge in bioethics, good clinical and laboratory practice, biosafety, data management and research administration as well as strong publication skills and ethics ..
- Innate Immune Protection by Clean Genome E. coliFrederick R Blattner; Fiscal Year: 2012..Further, development costs would be much lower than for conventional drugs, and pharmaceutical production of clean bacteria would be economical and highly efficient. ..
- Highly finished chromosome-based genome assembly for Anopheles gambiaeIgor V Sharakhov; Fiscal Year: 2012..Toward this goal, the proposed project will develop a high-quality genome assembly for Anopheles gambiae using high-throughput technologies. ..
- Mechanisms underlying loss of neural stem cell competence.Minoree Kohwi; Fiscal Year: 2013..Together, the above information will provide crucial insight into the origins of neural diversity and have wide implications in harnessing stem cells for tissue replacement therapies. ..
- B7-based, CD28 or CTLA-4-specific agonists and antagonists for tolerance inductioRoland K Strong; Fiscal Year: 2013....
- Drugs of Abuse Affecting AIDS PathogenesisThomas J Rogers; Fiscal Year: 2012..This application also includes administrative, animal, flow cytometry, and immunohistopathology cores to support the four research projects. PROGRAM PROJECT CHARACTERISTICS ..
- Regulation of Forebrain Neurogenesis by the Energy Sensor AMP KinaseBiplab Dasgupta; Fiscal Year: 2013..Identification of novel AMPK effectors and AMPK subunit-specific small molecule modulators could one day potentially lead to novel therapeutics for neurodegenerative and metabolic diseases. ..
- Post-transplant vaccines to enhance graft-versus-leukemia responsesCATHERINE JU YING WU; Fiscal Year: 2013..End of Abstract) ..
- 2/3 CBT for Anxiety Disorders in Autism: Adapting Treatment for AdolescentsEric A Storch; Fiscal Year: 2010..With more youth being diagnosed with ASD after the early childhood period, a treatment protocol such as that proposed could contribute to public health efforts to address the mental health needs of early adolescents with ASD. ..
- 3/3 CBT for Anxiety Disorders in Autism: Adapting Treatment for AdolescentsJILL EHRENREICH MAY; Fiscal Year: 2010..With more youth being diagnosed with ASD after the early childhood period, a treatment protocol such as that proposed could contribute to public health efforts to address the mental health needs of early adolescents with ASD. ..
- Health Care Partners in Cancer Prevention and Care Among Aged - Competing RenewalEva Kahana; Fiscal Year: 2013..Our focus on communication skills training among low health literacy and minority elders should also contribute to minimizing health disparities. ..
- Cyclic AMP Action During Sperm FunctionGeorge L Gerton; Fiscal Year: 2012..Understanding the role of SACY during spermatogenesis in the testis, sperm maturation in the epididymis, and sperm capacitation will allow us to improve the efficacy of sperm becoming fertilization-competent. ..
- From Child Maltreatment to Adolescent Substance Abuse: Risks, Protective FactorsPenelope K Trickett; Fiscal Year: 2010..abstract_text> ..
- First Step: Home/School Intervention for Preschoolers with Disruptive BehaviorsHILL M WALKER; Fiscal Year: 2013..abstract_text> ..
- Mucosal Immune Ontogeny and Intestinal Microbiota in InfantsEdward N Janoff; Fiscal Year: 2010..Children are particularly susceptible to mucosal infections. We do not as yet know how the immune response, which protects us against infections, develops in children. This proposal addresses this issue. ..
- Linking DNA Replication Origin Licensing with Cell Cycle ProgressionKate E Coleman; Fiscal Year: 2013..Ultimately, we anticipate that the long-term analysis of newly identified origin licensing regulators from these studies will guide the development of novel therapeutics for many human cancers. ..
- Epidemiology and Ecology of Vibrio cholerae in BangladeshRichard Bradley Sack; Fiscal Year: 2013..We postulate that factors in the marine environment play important roles in triggering the onset of epidemics. The study is being done in rural Bangladesh, using recently developed technology to further define these factors. ..
- Molecular basis for spotted fever group Rickettsia vector competence in ticksKevin R Macaluso; Fiscal Year: 2013....
- Role of PLAB1B in the Development of Hyperlipidemia Associated AtherosclerosisNORRIS ISAAC HOLLIE; Fiscal Year: 2013..Furthermore, the effect of Pla2g1b competence upon atherosclerosis development and systemic inflammation will be investigated in a mouse model of diet-induced atherosclerosis. ..
- Cognitive and Psychosocial Benefit of Caregiver Training for Ugandan HIV ChildrenMICHAEL JOSEPH BOIVIN; Fiscal Year: 2010....
- Best Practices in Mental Health Research Ethics Conference SeriesJames M DuBois; Fiscal Year: 2010..The proposed conference series will review empirical studies that address the ethical aspects of mental health research to identify best practices and areas requiring further investigation. ..
- MOUNT SINAI EMERGENCY MEDICINE RESEARCH CAREER DEVELOPMENT PROGRAMLynne D Richardson; Fiscal Year: 2013..abstract_text> ..
- Early experience and emotional development in free-ranging primatesKaren J Parker; Fiscal Year: 2013....
- Coaching Parents to Manage Youth Stress through Recreation and CultureHoward C Stevenson; Fiscal Year: 2010....
- MAPPING OF FILARIAL VECTOR COMPETENCE IN AEDES AEGYPTIDennis Knudson; Fiscal Year: 2002....
- Paracrine dysregulation of oocyte competence in PCOSDANIEL DUMESIC; Fiscal Year: 2006..abstract_text> ..
- Microfluidic devices for studying genetic competence in Streptococcus mutansSTEPHEN JAMES HAGEN; Fiscal Year: 2010..The goal of this project is to develop new laboratory devices with which we can study, and perhaps learn to control, this behavior. ..
- PROTEIN PHOSPHATASES AND OOCYTE MEIOSISGary Smith; Fiscal Year: 2002..These studies will provide novel information concerning control of oocyte maturation and spindle formation that may subsequently influence the developmental competency of resulting embryos. ..
- Comparative genomics of the 2La inversion breakpoints in Anopheles gambiaeIgor Sharakhov; Fiscal Year: 2009..The proposed research will identify candidate genes for vector competence. Our ability to control genes responsible for interference with parasite development will lead to the elimination of malaria transmission. ..
- The competence regulon in Streptococcus mutans biofilmsDennis G Cvitkovitch; Fiscal Year: 2011..mutans and potentially other biofilm-forming pathogens for optimal survival in biofilms and will hopefully lead to the design of means to control them. ..
- NONINVASIVE ASSESSMENT OF TRABECULAR ARCHITECTURESharmila Majumdar; Fiscal Year: 1999....
- Parent-Derived Measures of Parenting Competence for Low-Income African AmericansChristine McWayne; Fiscal Year: 2009..Further, we anticipate that any findings will have implications for early childhood programs serving low-income, African American families and children across our nation. ..
- Mothers as caregivers for survivors of brain tumorsJanet Deatrick; Fiscal Year: 2009....
- Provider Cultural Competence and Patient OutcomesKathryn Paez; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Antigen Specific T Cell Tolerance by Anti CD3 AntibodieClaudio Anasetti; Fiscal Year: 2001..2) Select for low avidity CD3 ligands which induce apoptosis of antigen- activated T cell but no pathogenicity. 3) Define signaling pathways which activate T cell apoptosis in response to CD3 ligation. ..