Summary: An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of EXERTION or endurance.

Top Publications

  1. pmc Inferring the rules of interaction of shoaling fish
    James E Herbert-Read
    School of Biological Sciences, University of Sydney, 2006 Sydney, Australia
    Proc Natl Acad Sci U S A 108:18726-31. 2011
  2. pmc Inferring the structure and dynamics of interactions in schooling fish
    Yael Katz
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 108:18720-5. 2011
  3. ncbi Antidepressant-like effect of different estrogenic compounds in the forced swimming test
    Erika Estrada-Camarena
    Depto de Farmacobiología CINVESTAV IPN, Calzada de los Tenorios 235, Col Granjas Coapa, Deleg Tlalpan, CP 14330 México DF, Mexico
    Neuropsychopharmacology 28:830-8. 2003
  4. pmc Digital holographic microscopy reveals prey-induced changes in swimming behavior of predatory dinoflagellates
    Jian Sheng
    Department of Mechanical Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 104:17512-7. 2007
  5. pmc Shoaling develops with age in Zebrafish (Danio rerio)
    Christine Buske
    Department of Cell and Systems Biology, Neuroscience, University of Toronto, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 35:1409-15. 2011
  6. ncbi Energetics of median and paired fin swimming, body and caudal fin swimming, and gait transition in parrotfish (Scarus schlegeli) and triggerfish (Rhinecanthus aculeatus)
    Keith E Korsmeyer
    Marine Biological Laboratory, University of Copenhagen, Strandpromenaden 5, Helsingør, DK 3000, Denmark
    J Exp Biol 205:1253-63. 2002
  7. pmc Neuropeptides regulate swimming depth of Platynereis larvae
    Markus Conzelmann
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 108:E1174-83. 2011
  8. ncbi The forced swimming test as a model for core and component behavioral effects of antidepressant drugs
    I Lucki
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104 2648, USA
    Behav Pharmacol 8:523-32. 1997
  9. ncbi Swimming of larval zebrafish: ontogeny of body waves and implications for locomotory development
    Ulrike K Müller
    Wageningen University, Experimental Zoology Group, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
    J Exp Biol 207:853-68. 2004
  10. pmc Control of visually guided behavior by distinct populations of spinal projection neurons
    Michael B Orger
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 11:327-33. 2008

Detail Information

Publications393 found, 100 shown here

  1. pmc Inferring the rules of interaction of shoaling fish
    James E Herbert-Read
    School of Biological Sciences, University of Sydney, 2006 Sydney, Australia
    Proc Natl Acad Sci U S A 108:18726-31. 2011
    ..The last two of these rules are different from the classical models of collective animal motion, raising new questions about how fish and other animals self-organize on the move...
  2. pmc Inferring the structure and dynamics of interactions in schooling fish
    Yael Katz
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 108:18720-5. 2011
    ..We begin by analyzing trajectories of golden shiners (Notemigonus crysoleucas) swimming in two-fish and three-fish shoals to map the mean effective forces as a function of fish positions and velocities...
  3. ncbi Antidepressant-like effect of different estrogenic compounds in the forced swimming test
    Erika Estrada-Camarena
    Depto de Farmacobiología CINVESTAV IPN, Calzada de los Tenorios 235, Col Granjas Coapa, Deleg Tlalpan, CP 14330 México DF, Mexico
    Neuropsychopharmacology 28:830-8. 2003
    ..25-1.0 mg/rat) in ovariectomized adult female Wistar rats using the forced swimming test (FST)...
  4. pmc Digital holographic microscopy reveals prey-induced changes in swimming behavior of predatory dinoflagellates
    Jian Sheng
    Department of Mechanical Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 104:17512-7. 2007
    The shallow depth of field of conventional microscopy hampers analyses of 3D swimming behavior of fast dinoflagellates, whose motility influences macroassemblages of these cells into often-observed dense "blooms...
  5. pmc Shoaling develops with age in Zebrafish (Danio rerio)
    Christine Buske
    Department of Cell and Systems Biology, Neuroscience, University of Toronto, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 35:1409-15. 2011
    ..day 7 post fertilization to over 5months of age by measuring the distance between all pairs of fish in freely swimming groups of ten subjects...
  6. ncbi Energetics of median and paired fin swimming, body and caudal fin swimming, and gait transition in parrotfish (Scarus schlegeli) and triggerfish (Rhinecanthus aculeatus)
    Keith E Korsmeyer
    Marine Biological Laboratory, University of Copenhagen, Strandpromenaden 5, Helsingør, DK 3000, Denmark
    J Exp Biol 205:1253-63. 2002
    To determine the energetic costs of rigid-body, median or paired-fin (MPF) swimming versus undulatory, body-caudal fin (BCF) swimming, we measured oxygen consumption as a function of swimming speed in two MPF swimming specialists, ..
  7. pmc Neuropeptides regulate swimming depth of Platynereis larvae
    Markus Conzelmann
    Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 108:E1174-83. 2011
    ..These changes influenced larval orientation, vertical swimming, and sinking, resulting in upward or downward shifts in the steady-state vertical distribution of larvae...
  8. ncbi The forced swimming test as a model for core and component behavioral effects of antidepressant drugs
    I Lucki
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104 2648, USA
    Behav Pharmacol 8:523-32. 1997
    ..The revised scoring of the forced swimming test corresponds to a behavioral test for antidepressant drugs that meet these criteria.
  9. ncbi Swimming of larval zebrafish: ontogeny of body waves and implications for locomotory development
    Ulrike K Müller
    Wageningen University, Experimental Zoology Group, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
    J Exp Biol 207:853-68. 2004
    ..to formulate a set of functional requirements that the locomotor system must fulfil to generate the observed swimming kinematics...
  10. pmc Control of visually guided behavior by distinct populations of spinal projection neurons
    Michael B Orger
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 11:327-33. 2008
    ..This description of the functional organization of the zebrafish motor system provides a framework for identifying the complete circuit underlying a vertebrate behavior...
  11. pmc Endogenous dopamine suppresses initiation of swimming in prefeeding zebrafish larvae
    Vatsala Thirumalai
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurophysiol 100:1635-48. 2008
    ..Zebrafish larvae exhibit marked changes in swimming behavior between 3 days postfertilization (dpf) and 5dpf...
  12. ncbi Prey capture by larval zebrafish: evidence for fine axial motor control
    Melissa A Borla
    Department of Biology, Northeastern University, Boston, Mass 02115, USA
    Brain Behav Evol 60:207-29. 2002
    b>Swimming and turning behaviors of larval zebrafish have been described kinematically, but prey capture behaviors are less well characterized...
  13. pmc Deep RNA sequencing of the skeletal muscle transcriptome in swimming fish
    Arjan P Palstra
    Departament de Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona and Institut de Biomedicina de la Universitat de Barcelona IBUB, Barcelona, Spain
    PLoS ONE 8:e53171. 2013
    ..mykiss) with the specific objective to identify expressed genes and quantify the transcriptomic effects of swimming-induced exercise...
  14. ncbi Zebrafish response to robotic fish: preference experiments on isolated individuals and small shoals
    G Polverino
    Department of Mechanical and Aerospace Engineering, Polytechnic Institute of New York University, Brooklyn, NY 11201, USA
    Bioinspir Biomim 7:036019. 2012
    ..Such robotic platforms may constitute a valuable tool to investigate the bases of social behaviour and uncover the fundamental determinants of animal functions and dysfunctions...
  15. pmc Episodic swimming in the larval zebrafish is generated by a spatially distributed spinal network with modular functional organization
    Timothy D Wiggin
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurophysiol 108:925-34. 2012
    ..When zebrafish begin swimming early in development, they perform short episodes of activity separated by periods of inactivity...
  16. ncbi A wake-based correlate of swimming performance and foraging behavior in seven co-occurring jellyfish species
    J O Dabiri
    Graduate Aeronautical Laboratories and Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Biol 213:1217-25. 2010
    ..This enables a quantitative, physically based understanding of how alterations in the fluid dynamics of aquatic and aerial animals throughout their evolution can result in distinct ecological functions...
  17. ncbi Hindbrain V2a neurons in the excitation of spinal locomotor circuits during zebrafish swimming
    Yukiko Kimura
    National Institutes of Natural Sciences, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, Okazaki, Aichi 444 8787, Japan
    Curr Biol 23:843-9. 2013
    ..Many of the V2a neurons in the hindbrain are known to project to the spinal cord in zebrafish, making hindbrain V2a neurons a prime candidate in descending locomotor drive...
  18. ncbi Effect of temperature on maximum swimming speed and cost of transport in juvenile European sea bass (Dicentrarchus labrax)
    Guy Claireaux
    Station Mediterraneenne de l Environnement Littoral, 1 Quai de la Daurade, Sete, 34200 France
    J Exp Biol 209:3420-8. 2006
    ..this study is among the few that have investigated the influence of the seasonal changes in water temperature on swimming performance in fish...
  19. ncbi Energetics and biomechanics as determining factors of swimming performance: updating the state of the art
    Tiago M Barbosa
    Polytechnic Institute of Braganca, Portugal
    J Sci Med Sport 13:262-9. 2010
    The biophysical determinants related to swimming performance are one of the most attractive topics within swimming science...
  20. ncbi Socioeconomic environment, availability of sports facilities, and jogging, swimming and gym use
    Cruz Pascual
    Department of Preventive Medicine and Public Health, Faculty of Medicine, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain
    Health Place 15:553-61. 2009
    ..to evaluate the association of the availability of sports facilities and socioeconomic environment with jogging, swimming and gym use in Spain...
  21. ncbi Hip velocity and arm coordination in front crawl swimming
    C Schnitzler
    Faculty of Sport Science from Rouen, Laboratory CETAPS UPRES EA 3832, University of Rouen, Faculty of Sports Sciences France, Mont Saint Aignan, France
    Int J Sports Med 31:875-81. 2010
    The hip intracyclic velocity variability and the index of coordination in front crawl swimming were examined in relation to performance level...
  22. pmc Spinal interneurons differentiate sequentially from those driving the fastest swimming movements in larval zebrafish to those driving the slowest ones
    David L McLean
    Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA
    J Neurosci 29:13566-77. 2009
    ..larval zebrafish that relates the position of motoneurons and interneurons to their order of recruitment during swimming. Here, we show that the map reflects an orderly pattern of differentiation of neurons driving different movements...
  23. pmc Three-dimensional neurophenotyping of adult zebrafish behavior
    Jonathan Cachat
    Department of Pharmacology and Neuroscience Program, Tulane Neurophenotyping Platform and Zebrafish Neuroscience Research Consortium, Tulane University Medical School, New Orleans, Louisiana, United States of America
    PLoS ONE 6:e17597. 2011
    ..to improve quantification of automated parameters, and suggests that spatiotemporal organization of zebrafish swimming activity can be affected by various experimental manipulations in a manner predicted by their anxiolytic or ..
  24. ncbi Effects of high intensity exercise training on cardiovascular function, oxygen uptake, internal oxygen transport and osmotic balance in chinook salmon (Oncorhynchus tshawytscha) during critical speed swimming
    P E Gallaugher
    Continuing Studies in Science, Simon Fraser University, Burnaby, BC, Canada
    J Exp Biol 204:2861-72. 2001
    ..function, oxygen consumption, oxygen delivery and osmotic balance were measured at velocities up to critical swimming speed (Ucrit) in seawater-adapted chinook salmon. We used two groups of fish...
  25. ncbi Forced swimming test in mice: a review of antidepressant activity
    Benoit Petit-Demouliere
    EA 3256 Neurobiologie de l Anxiété et de la Dépression, Faculte de Medecine, BP 53508, 1 rue Gaston Veil, F44035 Nantes Cedex 01, France
    Psychopharmacology (Berl) 177:245-55. 2005
    Among all animal models, the forced swimming test (FST) remains one of the most used tools for screening antidepressants.
  26. ncbi A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment
    Catharine H Duman
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:661-70. 2007
    ..BDNF-regulated signaling pathways are thus potential targets for investigation of antidepressant mechanisms...
  27. ncbi Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration
    Tatyana Strekalova
    Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Neuropsychopharmacology 29:2007-17. 2004
    ..stress per se, is associated with key analogues of depressive symptoms, such as increased floating during forced swimming and decreased exploration of novelty...
  28. ncbi Fictive swimming motor patterns in wild type and mutant larval zebrafish
    Mark A Masino
    Cornell Univ, Dept of Neurobiology and Behavior, W101 Mudd Hall, Ithaca, NY 14853, USA
    J Neurophysiol 93:3177-88. 2005
    ..a unique model for investigating the mechanisms involved in generating rhythmic patterns of behavior, such as swimming, due to the array of techniques available including genetics, optical imaging, and conventional electrophysiology...
  29. ncbi Prey tracking by larval zebrafish: axial kinematics and visual control
    Melissa B McElligott
    Department of Biology, Northeastern University, Boston, MA 02115, USA
    Brain Behav Evol 66:177-96. 2005
    ..2002]. Tracking movements were classified as either swimming or turning bouts...
  30. ncbi Exposure to novelty and forced swimming evoke stressor-dependent changes in extracellular GABA in the rat hippocampus
    L de Groote
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, Department of Clinical Science at South Bristol, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
    Neuroscience 148:794-805. 2007
    ..Next, rats were exposed to a novel cage or to forced swimming in 25 degrees C water. Interestingly, these two stressors resulted in opposite effects...
  31. ncbi Flow patterns generated by oblate medusan jellyfish: field measurements and laboratory analyses
    John O Dabiri
    Bioengineering and Graduate Aeronautical Laboratories, California Institute of Technology, Mail Code 301 46, Pasadena, CA 91125, USA
    J Exp Biol 208:1257-65. 2005
    ..how this is achieved, we employed dye visualization techniques on scyphomedusae (Aurelia aurita) observed swimming in their natural marine habitat...
  32. pmc Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior
    Michael Demarque
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0357, USA
    Neuron 67:321-34. 2010
    ..of Lmx1b expression, we also demonstrate that changes in the number of serotonergic neurons change larval swimming behavior...
  33. ncbi Bio-inspired magnetic swimming microrobots for biomedical applications
    Kathrin E Peyer
    Institute of Robotics and Intelligent Systems, ETH Zurich, Switzerland
    Nanoscale 5:1259-72. 2013
    ..This article reviews the various swimming methods with particular focus on helical propulsion inspired by E. coli bacteria...
  34. ncbi Antidepressant-like effects of sodium butyrate in combination with estrogen in rat forced swimming test: involvement of 5-HT(1A) receptors
    Hong Zhu
    Hefei National Laboratory for Physical Sciences at Microscale, Department of Neurobiology, School of Life Science, University of Science and Technology of China, Hefei, China
    Behav Brain Res 196:200-6. 2009
    ..whether NaB administered in combination with estradiol benzoate (EB) exerted antidepressant-like effect in forced swimming test (FST) in ovariectomized female rats...
  35. ncbi Movement and function of the pectoral fins of the larval zebrafish (Danio rerio) during slow swimming
    Matthew H Green
    Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60637, USA
    J Exp Biol 214:3111-23. 2011
    Pectoral fins are known to play important roles in swimming for many adult fish; however, their functions in fish larvae are unclear...
  36. pmc Deciphering interactions in moving animal groups
    Jacques Gautrais
    Centre de Recherches sur la Cognition Animale, UMR CNRS 5169, Universite Paul Sabatier, Toulouse, France
    PLoS Comput Biol 8:e1002678. 2012
    ..that both positional and orientational effects are present, act upon the fish turning speed, and depend on the swimming speed, yielding a novel schooling model whose parameters are all estimated from data...
  37. ncbi Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus
    Lêda S B Garcia
    Laboratorio de Neurociencias, Programa de Pos Graduacao em Ciencias da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 88806 000 Criciuma, SC, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 32:140-4. 2008
    ..5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) and animal behavioral was assessed in the forced swimming and open-field tests...
  38. ncbi Morphological diversity of medusan lineages constrained by animal-fluid interactions
    John O Dabiri
    Graduate Aeronautical Laboratories and Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Biol 210:1868-73. 2007
    ..demonstrates that constraints in available locomotor muscular force result in a trade-off between high-thrust swimming via jet propulsion and high-efficiency swimming via a combined jet-paddling propulsion...
  39. ncbi Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress
    Seiji Hitoshi
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5 1 Higashiyama, Myodaiji, Okazaki, Japan
    J Neurosci Res 85:3574-85. 2007
    ..These data provide insights into the molecular mechanisms underlying the pharmacological actions of antidepressant drugs...
  40. ncbi Metamorphosis-induced changes in the coupling of spinal thoraco-lumbar motor outputs during swimming in Xenopus laevis
    Anna Beyeler
    Universite de Bordeaux, Centre National de la Recherche Scientifique, Laboratoire Mouvement Adaptation Cognition UMR 5227 Bordeaux, France
    J Neurophysiol 100:1372-83. 2008
    ..we have investigated the coordination between postural back and hindlimb muscle activity during free forward swimming. Axial/dorsal muscles, which contract in bilateral alternation during undulatory swimming in premetamorphic ..
  41. pmc A review of fish swimming mechanics and behaviour in altered flows
    James C Liao
    Department of Neurobiology and Behaviour, Cornell University, Ithaca, NY 1480, USA
    Philos Trans R Soc Lond B Biol Sci 362:1973-93. 2007
    ..of abiotic and biotic sources that alter otherwise uniform flows, which then have the potential to perturb the swimming motions of fishes...
  42. ncbi Antidepressant-like effects of the CRF family peptides, urocortin 1, urocortin 2 and urocortin 3 in a modified forced swimming test in mice
    Masaru Tanaka
    Institute of Pathophysiology, University of Szeged, Semmelweis u 1, H 6701 Szeged, Hungary
    Brain Res Bull 75:509-12. 2008
    ..13, 0.25 and 0.5 microg/2 microl, i.c.v.) were assayed in mice in a modified forced swimming test (FST)...
  43. ncbi Sink fast and swim harder! Round-trip cost-of-transport for buoyant divers
    Patrick J O Miller
    Sea Mammal Research Unit, School of Biology, University of St Andrews, Fife KY16 9QQ, UK
    J Exp Biol 215:3622-30. 2012
    ..However, at body-density extremes, both models predict that savings in the aided direction do not fully offset the increased COT imposed by the greater thrusting required in the hindered direction...
  44. ncbi Adaptation of rainbow fish to lake and stream habitats
    Katrina McGuigan
    Department of Zoology and Entomology, The University of Queensland, Brisbane, Queensland, Australia 4072
    Evolution 57:104-18. 2003
    ..As predicted, decreased demand for sustained swimming in lakes resulted in a reduction in caudal red muscle area of lake fish relative to their stream counterparts...
  45. ncbi Does net energy cost of swimming affect time to exhaustion at the individual's maximal oxygen consumption velocity?
    R J Fernandes
    Faculty of Sport Sciences and Physical Education, Swimming Department, University of Porto, Porto, Portugal
    J Sports Med Phys Fitness 46:373-80. 2006
    ..limit at the minimum velocity that elicits the individual's maximal oxygen consumption (TLim-v VO2max) and three swimming economy related parameters: the net energy cost corresponding to v VO2max (Cv VO2max), the slope of the ..
  46. ncbi Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test
    C Lopez-Rubalcava
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Neuropsychopharmacology 22:191-9. 2000
    ..response to different types of antidepressant drugs between WKY and Sprague-Dawley (SD) rats in the forced swimming test (FST). WKY rats displayed significantly greater immobility than SD rats during their exposure to the FST...
  47. ncbi Numerical investigation of the hydrodynamics of carangiform swimming in the transitional and inertial flow regimes
    Iman Borazjani
    St Anthony Falls Laboratory, University of Minnesota, Minneapolis, MN 55402, USA
    J Exp Biol 211:1541-58. 2008
    ..The propulsive efficiency at St* is an increasing function of Re while the power required for swimming is decreasing with Re...
  48. ncbi Visual control of steering in the box jellyfish Tripedalia cystophora
    Ronald Petie
    Department of Biology, Lund University, Biology Building B, Sölvegatan 35, 223 62 Lund, Sweden
    J Exp Biol 214:2809-15. 2011
    ..However, it is not known how visual input controls the swimming behaviour...
  49. ncbi Differences in locomotor performance between individuals: importance of parvalbumin, calcium handling and metabolism
    Frank Seebacher
    School of Biological Sciences A08, University of Sydney, NSW 2006, Australia
    J Exp Biol 215:663-70. 2012
    ..We provide mechanistic explanations of why locomotor performance differs between individuals, which is important for understanding ecological and sporting success, disease and the evolutionary processes underlying selection...
  50. pmc Rapidly measured indicators of recreational water quality and swimming-associated illness at marine beaches: a prospective cohort study
    Timothy J Wade
    United States Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, North Carolina, USA
    Environ Health 9:66. 2010
    ..United States and elsewhere, recreational water quality is monitored for fecal indicator bacteria to help prevent swimming-associated illnesses. Standard methods to measure these bacteria take at least 24 hours to obtain results...
  51. ncbi Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice
    Fraser Murray
    Merck Sharp and Dohme, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR United Kingdom
    Eur J Pharmacol 583:115-27. 2008
    ..The results presented here demonstrate that moderately elevated corticosterone for a prolonged period is sufficient to induce cellular changes in the hippocampus that are prevented by chronic administration of antidepressants...
  52. ncbi Swimming speeds and buoyancy compensation of migrating adult chum salmon Oncorhynchus keta revealed by speed/depth/acceleration data logger
    H Tanaka
    National Institute of Polar Research, 1 9 10 Kaga, Itabashi, Tokyo 173 8515, Japan
    J Exp Biol 204:3895-904. 2001
    Although the homing migration of Pacific salmon is well documented, the swimming behaviour of the returning salmon has been poorly described, principally as a result of the difficulties encountered in monitoring salmon behaviour in the ..
  53. ncbi Reductions in prolonged swimming capacity following freshwater colonization in multiple threespine stickleback populations
    Anne C Dalziel
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    Evolution 66:1226-39. 2012
    ..stickleback (Gasterosteus aculeatus) populations to examine the outcome of relaxed selection on prolonged swimming performance...
  54. ncbi Performance limits of labriform propulsion and correlates with fin shape and motion
    Jeffrey A Walker
    Department of Biology, University of Southern Maine, 96 Falmouth Street, Portland, ME 04103
    J Exp Biol 205:177-87. 2002
    ..and the results of the simulation experiment are consistent with natural variation, we compared the steady swimming performance (critical swimming speed) of four species of labrid fish (Cirrhilabrus rubripinnis, Pseudocheilinus ..
  55. ncbi Effects of swimming training on blood pressure and vascular function in adults >50 years of age
    Nantinee Nualnim
    Cardiovascular Aging Research Laboratory, Department of Kinesiology and Health Education, The University of Texas at Austin, USA
    Am J Cardiol 109:1005-10. 2012
    b>Swimming is ideal for older adults because it includes minimum weight-bearing stress and decreased heat load. However, there is very little information available concerning the effects of regular swimming exercise on vascular risks...
  56. ncbi In the rat forced swimming test, chronic but not subacute administration of dual 5-HT/NA antidepressant treatments may produce greater effects than selective drugs
    Jean Philippe Reneric
    Laboratoire de Neuropsychobiologie des Desadaptations, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5541, BP31, Universite Bordeaux II, 33076 Bordeaux Cedex, France
    Behav Brain Res 136:521-32. 2002
    The rat forced swimming test (FST) distinguishes selective serotonin (5-HT) and selective noradrenaline (NA) reuptake-inhibitors, which respectively increase swimming and climbing behaviours...
  57. ncbi Time limit at VO2max velocity in elite crawl swimmers
    R J Fernandes
    Swimming, Faculty of Sport, University of Porto, Porto, Portugal
    Int J Sports Med 29:145-50. 2008
    ..Additionally, O2SC seems to be a determinant of TLim-vVO2max...
  58. ncbi Involvement of NMDA receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test
    Andrea D E Zomkowski
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, 88040 900, SC, Brazil
    Eur Neuropsychopharmacol 20:793-801. 2010
    ..This study investigated the effect of escitalopram in forced swimming test (FST) and in the tail suspension test (TST) in mice, and tested the hypothesis that the inhibition of NMDA ..
  59. pmc Intracerebroventricular administration of HIV-1 Tat induces brain cytokine and indoleamine 2,3-dioxygenase expression: a possible mechanism for AIDS comorbid depression
    Marcus A Lawson
    Neuroscience Program University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Brain Behav Immun 25:1569-75. 2011
    ..The results reveal a potential role for Tat in the development of comorbid depression in HIV-infected individuals...
  60. ncbi An energy balance of the 200 m front crawl race
    Pedro Figueiredo
    Faculty of Sport, Center of Research, Education, Innovation and Intervention in Sport, University of Porto, Porto, Portugal
    Eur J Appl Physiol 111:767-77. 2011
    ..was measured during the 200 m swim and blood samples were collected before and after each swim; the C of swimming was calculated as the ratio of E (tot) to distance (where E (tot) = Aer + AnL + AnAl)...
  61. ncbi On the mechanism of antidepressant-like action of berberine chloride
    Shrinivas K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Eur J Pharmacol 589:163-72. 2008
    ..Further, nitric oxide pathway and/or sigma receptors are involved in mediating its antidepressant-like activity in mouse forced swim test...
  62. ncbi Morphology, swimming performance and propulsive mode of six co-occurring hydromedusae
    Sean P Colin
    Department of Marine Sciences, University of Connecticut, 1084 Shennecossett Road, Groton, CT 06340, USA
    J Exp Biol 205:427-37. 2002
    Jet propulsion, based on examples from the Hydrozoa, has served as a valuable model for swimming by medusae...
  63. ncbi Modeling the links between young swimmers' performance: energetic and biomechanic profiles
    Tiago M Barbosa
    Polytechnic Institute Bragança, Bragança, Portugal
    Pediatr Exerc Sci 22:379-91. 2010
    ..For biomechanical assessment the stroke length, the stroke frequency and the swimming velocity were analyzed...
  64. ncbi Aging performance for masters records in athletics, swimming, rowing, cycling, triathlon, and weightlifting
    A Barry Baker
    Department of Anaesthesia, University of Sydney at Royal Prince Alfred Hospital, Sydney, Australia
    Exp Aging Res 36:453-77. 2010
    Record performances for Masters sporting events for swimming, cycling, triathlon, rowing, and weightlifting were analyzed and then compared with the authors' previously published results for Masters running, walking, and jumping sports ..
  65. pmc Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice
    J C O'Connor
    Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Mol Psychiatry 14:511-22. 2009
    ..These results implicate IDO as a critical molecular mediator of inflammation-induced depressive-like behavior, probably through the catabolism of tryptophan along the kynurenine pathway...
  66. ncbi Intracyclic velocity variations and arm coordination during exhaustive exercise in front crawl stroke
    M Alberty
    Laboratoire d Etudes de la Motricite Humaine, Faculte des Sciences du Sport, Universite de Lille 2, France
    Int J Sports Med 26:471-5. 2005
  67. ncbi D4 Dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour
    W Boehmler
    Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA
    Genes Brain Behav 6:155-66. 2007
    ..Our data suggest that the inhibitory effect of clozapine on the locomotor activity of larval zebrafish may be mediated through D4Rs...
  68. ncbi Habitual throwing and swimming correspond with upper limb diaphyseal strength and shape in modern human athletes
    Colin N Shaw
    Leverhulme Centre for Human Evolutionary Studies, Department of Biological Anthropology, University of Cambridge, Cambridge CB2 1QH, UK
    Am J Phys Anthropol 140:160-72. 2009
    ..The reported correspondence between habitual activity patterns and upper limb diaphyseal properties may inform future behavioral interpretations involving hominin skeletal remains...
  69. ncbi Effect of fatigue on the intra-cycle acceleration in front crawl swimming: a time-frequency analysis
    V Tella
    Departamento de Educacion Fisica, Universidad de Valencia, Spain
    J Biomech 41:86-92. 2008
    ..5%, respectively. Our results show that the acceleration analysis of the swimmer with Fourier analysis permits a more precise understanding of which propulsive forces contribute to the swimmer performance before and after fatigue appears...
  70. ncbi Endurance exercise training ameliorates insulin resistance and reticulum stress in adipose and hepatic tissue in obese rats
    Gabrielle Da Luz
    Laboratorio de Fisiologia e Bioquimica do Exercicio, Programa de Pos Graduacao em Ciencias da Saude, Universidade do Extremo Sul Catarinense, Criciuma, SC 88806 000, Brazil
    Eur J Appl Physiol 111:2015-23. 2011
    ..After that rats were submitted to swimming training (1 h per day, 5 days for week with 5% overload of the body weight for 8 weeks)...
  71. ncbi The role of 5-HT₁A receptors in fish oil-mediated increased BDNF expression in the rat hippocampus and cortex: a possible antidepressant mechanism
    Aparecida Vines
    Laboratorio de Neurofisiologia, Departamento de Fisiologia, Universidade Federal do Parana, 81 531 990 Curitiba, PR, Brazil
    Neuropharmacology 62:184-91. 2012
    ..This article is part of a Special Issue entitled 'Anxiety and Depression'...
  72. ncbi Aspartame-fed zebrafish exhibit acute deaths with swimming defects and saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein activity in hypercholesterolemia
    Jae Yong Kim
    School of Biotechnology, Yeungnam University, Gyeongsan 712 749, Republic of Korea
    Food Chem Toxicol 49:2899-905. 2011
    ..After 12 days, 30% of zebrafish, which consumed aspartame and HCD, died with exhibiting swimming defects. The aspartame group had 65% survivability, while the control and saccharin groups had 100% survivability...
  73. pmc The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior
    Gor Sarkisyan
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Behav Brain Res 209:99-108. 2010
    ..The data furthermore support the hypothesis that the 5-HT(7) receptor might be a suitable target for treating depression...
  74. pmc Swimming physiology of European silver eels (Anguilla anguilla L.): energetic costs and effects on sexual maturation and reproduction
    Arjan P Palstra
    Molecular Cell Biology, Institute of Biology, Leiden University IBL, Leiden, The Netherlands
    Fish Physiol Biochem 36:297-322. 2010
    ..Because they venture into the ocean in a pre-pubertal state and reproduce after swimming for months, a strong interaction between swimming and sexual maturation is expected...
  75. ncbi Both incubation temperature and posthatching temperature affect swimming performance and morphology of wood frog tadpoles (Rana sylvatica)
    Timothy B Watkins
    Department of Biology, Macalester College, St Paul, MN, 55105, USA
    Physiol Biochem Zool 79:140-9. 2006
    ..We measured body size, size-independent morphology, and burst swimming speed at one developmental stage...
  76. ncbi An epidemiological investigation of an outbreak of leptospirosis associated with swimming, Beaufort, Sabah
    T K Koay
    Kudat Health Office, Beg Berkunci No 6, Kudat, Sabah
    Med J Malaysia 59:455-9. 2004
    ..October 13 to October 21, 1999, a total of 46 males, aged 8 to 19 years, were admitted to Beaufort Hospital after swimming in the creek near an oil palm plantation in Kampung (Kg) Kebatu, Beaufort...
  77. ncbi Excess post-exercise oxygen consumption in adult sockeye (Oncorhynchus nerka) and coho (O. kisutch) salmon following critical speed swimming
    C G Lee
    Biological Sciences, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada
    J Exp Biol 206:3253-60. 2003
    The present study measured the excess post-exercise oxygen cost (EPOC) following tests at critical swimming speed (Ucrit) in three stocks of adult, wild, Pacific salmon (Oncorhynchus sp...
  78. ncbi Visually guided obstacle avoidance in the box jellyfish Tripedalia cystophora and Chiropsella bronzie
    A Garm
    Department of Cell and Organism Biology, Lund University, Helgonavagen 3, 22362 Lund, Sweden
    J Exp Biol 210:3616-23. 2007
    ..In the flow chamber Tripedalia cystophora displayed a stronger obstacle avoidance response than Chiropsella bronzie since they had less contact with the obstacles. This seems to follow differences in their habitats...
  79. ncbi Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression
    Haixia Dang
    Research Center of Pharmacology and Toxicology, Peking Union Medical College, Institute of Medicinal Plant Development, Beijing, 100193, PR China
    Prog Neuropsychopharmacol Biol Psychiatry 33:1417-24. 2009
    ..In the present study, two classic animal models: the forced swimming test (FST) and the chronic mild stress (CMS) model were used to evaluate the antidepressant-like activities of ..
  80. pmc Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin
    Andrés Vidal-Gadea
    Section of Neurobiology, Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 108:17504-9. 2011
    ..We demonstrate that C. elegans uses biogenic amines to switch between distinct crawling and swimming gaits. Dopamine is necessary and sufficient to initiate and maintain crawling after swimming...
  81. pmc Continuous shifts in the active set of spinal interneurons during changes in locomotor speed
    David L McLean
    Department of Neurobiology and Behavior, w103 Mudd Hall Cornell University, Ithaca, New York 14853, USA
    Nat Neurosci 11:1419-29. 2008
    ..We explored the activity of pools of spinal interneurons in larval zebrafish and found that increases in swimming speed were not associated with the simple addition of cells to the active pool...
  82. ncbi Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine
    Inge Sillaber
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Psychopharmacology (Berl) 200:557-72. 2008
    ..Monoamine-based antidepressants inhibit neurotransmitter reuptake within short time. However, it commonly takes several weeks until clinical symptoms start to resolve--indicating the involvement of effects distant from reuptake inhibition...
  83. ncbi Growth and metabolism of larval zebrafish: effects of swim training
    B Bagatto
    Department of Biological Sciences, University of North Texas, Denton, Texas, 76203, USA
    J Exp Biol 204:4335-43. 2001
    ..Danio rerio) of three different age classes ('yolk-sac' larvae, 96 h; 'swim-up' larvae, 9 days old; and 'free-swimming' larvae, 21 days old) were trained for 2, 6 and 11 days, respectively, to swim at 0 body lengths per second (BL s(..
  84. pmc Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression
    Britta Haenisch
    Institute of Pharmacology and Toxicology, University of Bonn, Bonn, Germany
    J Neurochem 111:403-16. 2009
    ..In addition, these mice represent a useful model to study depression-resistant behaviors, and they might help to provide deeper insights into the identification of downstream targets involved in the mechanisms of antidepressants...
  85. ncbi Swimming of larval zebrafish: fin-axis coordination and implications for function and neural control
    Dean H Thorsen
    Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA
    J Exp Biol 207:4175-83. 2004
    Adult actinopterygian fishes typically perform steady forward swimming using either their pectoral fins or their body axis as the primary propulsor...
  86. ncbi Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test
    Andréa Dias Elpo Zomkowski
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Campus Universitario, Trindade, Florianopolis 88040 900, SC, Brazil
    Brain Res 1023:253-63. 2004
    ..involvement of 5-HT(1) and 5-HT(2) receptors in the antidepressant-like effect of agmatine in the mouse forced swimming test (FST). Pretreatment with p-chlorophenylalanine methyl ester (PCPA; 100 mg/kg, intraperitoneally (i.p...
  87. ncbi Oceanic spawning migration of the European eel (Anguilla anguilla)
    Kim Aarestrup
    Technical University of Denmark DTU, National Institute of Aquatic Resources, Vejlsøvej 39, DK 8600 Silkeborg, Denmark
    Science 325:1660. 2009
    ..Here, we present information about the swimming direction, depth, and migratory behavior of European eels during spawning migration, based on a miniaturized pop-..
  88. pmc Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training
    Jason S Snyder
    National Institutes of Health, Bethesda, Maryland 20892, USA
    Hippocampus 19:360-70. 2009
  89. pmc A parallel cholinergic brainstem pathway for enhancing locomotor drive
    Roy Smetana
    Department of Biological Sciences and Laboratory in Neurobiology, University of Illinois at Chicago, Chicago, Illinois, USA
    Nat Neurosci 13:731-8. 2010
    ..The presence of these neurons forces us to rethink the organization of supraspinal locomotor control, to include a sustained feedforward loop that boosts locomotor output...
  90. pmc Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease
    Nigel I Wood
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e9077. 2010
    ..We have also shown previously that HD patients and R6/2 mice have disrupted circadian rhythms, treatment of which may improve cognition, general health, and survival...
  91. ncbi Sink or swim: strategies for cost-efficient diving by marine mammals
    T M Williams
    Department of Biology, EMS A316, University of California, Santa Cruz, CA 95064, USA
    Science 288:133-6. 2000
    ..2 to 59.6% reduction in diving energetic costs. This energy-conserving strategy allows marine mammals to increase aerobic dive duration and achieve remarkable depths despite limited oxygen availability when submerged...
  92. ncbi Ethanol effects on three strains of zebrafish: model system for genetic investigations
    Cynthia A Dlugos
    Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, 317 Farber Hall, Buffalo, NY 14214 3000, USA
    Pharmacol Biochem Behav 74:471-80. 2003
    ..Although preliminary, the present study indicates that the zebrafish is an excellent model system to investigate the genetic determinants involved in regulating the responses to ethanol...
  93. pmc Outbreaks of waterborne infectious intestinal disease in England and Wales, 1992-2003
    A Smith
    Health Protection Agency, Centre for Infections London, UK
    Epidemiol Infect 134:1141-9. 2006
    ..Public water supplies were implicated in 24 outbreaks (27%), private water supplies in 25 (28%), swimming pools in 35 (39%) and other sources in five outbreaks (6%)...
  94. ncbi Interaction of hypercaloric diet and physical exercise on lipid profile, oxidative stress and antioxidant defenses
    Regina C M Burneiko
    Department of Chemistry and Biochemistry, Institute of Biological Sciences, Sao Paulo State University, UNESP, 18618 000 Botucatu, Sao Paulo, Brazil
    Food Chem Toxicol 44:1167-72. 2006
    ..The swimming was selected as a model for exercise performance...
  95. ncbi Maximal lactate steady state in rats submitted to swimming exercise
    C A Gobatto
    Department of Physical Education, Bioscience Institute, University of Sao Paulo State Unesp, Avenida 24 A, 1515 Bela Vista, Rio Claro, Sao Paulo, 13506 900 Brazil
    Comp Biochem Physiol A Mol Integr Physiol 130:21-7. 2001
    ..The aim of the present study was to determine MLSS in rats during swimming exercise. Adult male Wistar rats, which were adapted to water for 3 weeks, were used...
  96. ncbi Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats
    K Sairam
    Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Phytomedicine 9:207-11. 2002
  97. ncbi Axonal regrowth after spinal cord transection in adult zebrafish
    T Becker
    Department of Neurobiology, Swiss Federal Institute of Technology, Honggerberg, Zurich, Switzerland
    J Comp Neurol 377:577-95. 1997
    ..Terminal fields were not re-established in the torus semicircularis and the eminentia granularis following spinal cord transection...
  98. ncbi Protein and lipid oxidative damage in streptozotocin-induced diabetic rats submitted to forced swimming test: the insulin and clonazepam effect
    Carlos Alberto Yasin Wayhs
    Programa de Pós Graduação em Ciências Farmacêuticas, Porto Alegre, RS, Brazil
    Metab Brain Dis 25:297-304. 2010
    ..We investigated oxidative stress parameters in streptozotocin-induced diabetic rats submitted to forced swimming test (STZ) and evaluated the effect of insulin (STZ-INS) and/or clonazepam (STZ-CNZ and STZ-INS-CNZ) acute ..
  99. ncbi Early remodeling of rat cardiac muscle induced by swimming training
    R M M Verzola
    Departamento de Ciencias Fisiologicas, Universidade Federal de Sao Carlos, Sao Carlos, SP, Brasil
    Braz J Med Biol Res 39:621-7. 2006
    The aim of the present investigation was to study the effect of acute swimming training with an anaerobic component on matrix metallopeptidase (MMP) activity and myosin heavy chain gene expression in the rat myocardium...
  100. ncbi Fast-swimming hydromedusae exploit velar kinematics to form an optimal vortex wake
    John O Dabiri
    Graduate Aeronautical Laboratories and Bioengineering, California Institute of Technology, Mail Code 138 78, Pasadena, CA 91125, USA
    J Exp Biol 209:2025-33. 2006
    Fast-swimming hydromedusan jellyfish possess a characteristic funnel-shaped velum at the exit of their oral cavity that interacts with the pulsed jets of water ejected during swimming motions...
  101. ncbi Behavioural responses of hatchery-reared and wild cod Gadus morhua to mechano-acoustic predator signals
    J J Meager
    Department of Biology, University of Bergen, P O Box 7800, Bergen N 5020, Norway
    J Fish Biol 78:1437-50. 2011
    ..This suggests that experience plays a role in shaping the behavioural response of fishes to MA stimuli...

Research Grants62

    THOMAS W OWEN; Fiscal Year: 2011
    ..coli O157:H7 infections can spread through contaminated food, contaminated drinking water, contaminated swimming water, and from toddler to toddler at a day care center...
  2. 5-HT transporter function: Interaction of hormones and antidepressants
    Alan Frazer; Fiscal Year: 2013
    ..The new techniques to be used are in vivo microdialysis and the forced swimming test (FST)...
  3. Presynaptic Mechanisms Regulating the Dopamine Transporter
    JAMES A HARDAWAY; Fiscal Year: 2013
    ..spillover of DA produced by pharmacological or genetic loss of DAT (DAT-1) induces a locomotory phenotype called Swimming Induced Paralysis (SWIP)...
    NINA REDA SALAMA; Fiscal Year: 2010
    ..All mutants tested show slight, but reproducible defects in halo formation in soft agar suggesting compromised swimming or chemotaxis...
  5. Effect of Helicobacter pylori cell shape on pathogenesis
    ..Our preliminary studies suggest that cell shape plays a role in H. pylori's swimming velocity or some other aspect of swimming behavior. We hypothesize that helical cell shape is important for H...
  6. 5-HT transporter function: Interaction of antidepressants and hormones
    Alan Frazer; Fiscal Year: 2013
    ..to extend these studies using other measures, either neurochemical (in vivo microdialysis) or behavioral (forced swimming test (FST)), to see if additional types of evidence can be obtained showing that treatment with female sex ..
  7. Temporal Requirements for Intracellular Pathogenesis
    Darren E Higgins; Fiscal Year: 2012
    ..Lm uses flagellar (swimming) motility to survive in extracellular environmental niches and aid in the invasion of host cells...
  8. Linking Limnology to Cyanotoxins in Drinking Water Using Buoy Sensors and Auto-Sa
    Todd R Miller; Fiscal Year: 2013
    ..As a result there is increasing risk associated with lake recreational activities (e.g. swimming, boating), and consumption of fish...
  9. Rapid Point-of-Care Test Kit for the Detection of Bacteriuria Calibrated for Imme
    MARK GEISBERG; Fiscal Year: 2010
    ..based on the applicant Company's proprietary Watersafe(r) Bacteria Test, a rapid immunoassay for bacteria in swimming pools, which is currently manufactured and marketed by the Company...
  10. Point-of-Care Diagnostic Assay for Direct Detection of Pathogenic Leptospira
    Jeffrey Smith; Fiscal Year: 2010
    ..workers to children playing in rain puddles or mud, as well as people engaging in recreational activities such as swimming, boating, caving or fishing. In short, there are few people who are not at risk of leptospirosis infection...
  11. Mechanotransduction Approach to Improve Bone Quality in Osteogenesis Imperfecta
    Charlotte L Phillips; Fiscal Year: 2012
    ..molecular mechanisms [G610C/+ (models human type I and IV OI)] to investigate the impact of non-weight bearing (swimming) and weight bearing (treadmill) exercise on muscle strength and bone quality and strength...
  12. Genetic basis of sperm competition in Peromyscus
    Heidi S Fisher; Fiscal Year: 2010
    ..mouse, the genus Peromyscus, exhibit striking differences in testes size, ejaculate traits, sperm morphology and swimming performance between species...
  13. Computational Genomics of Signal Transduction
    IGOR B JOULINE; Fiscal Year: 2013
    ..allows bacteria to detect external stimuli via chemoreceptors in the cell membrane and control the cell's swimming behavior through phosphorylation of a response regulator protein by a histidine protein kinase...
  14. Presynaptic Regulation of C.elegans Dopamine Transporter
    Randy D Blakely; Fiscal Year: 2013
    ..5, dat-1). The present effort arises from our discovery of a simple DA and dat-1 dependent phenotype termed Swimming-Induced Paralysis (SWIP)...
  15. Forward Genetics and the Presynaptic Dopamine Transporter
    Randy D Blakely; Fiscal Year: 2010
    ..elegans, termed Swimming-Induced Paralysis (SWIP), to identify proteins involved in the localization and regulation of cocaine and ..
  16. Zebrafish as a natural host model for Vibrio cholerae
    Jeffrey H Withey; Fiscal Year: 2012
    ..of zebrafish, which is important for the design of future experiments and will illuminate the dynamics of free swimming V. cholerae and fish in the natural environment. Finally, we will determine how secreted factors from V...
  17. Assembly and Function of Bacterial Chemotaxis Receptor Signaling Complexes
    Robert M Weis; Fiscal Year: 2013
    ..These pathways are already known to mediate chemotaxis and phototaxis in free-swimming and surface-associated bacteria, but are being recognized increasingly to regulate multicellular aggregation, ..
  18. Genetic Analysis of Inner Ear Development in Xenopus tropicalis
    Richard M Harland; Fiscal Year: 2013
    ..Furthermore, defects in ear development lead to abnormal swimming behavior and loss of the righting response, so that defects that may not be anatomically obvious can also be ..
  19. Elucidation of a bacterial cell shape generating program and pathogenic functions
    NINA REDA SALAMA; Fiscal Year: 2013
    ..by which the helical cell shape generating program promotes stomach colonization including modulation of swimming behavior and niche utilization within the stomach...
  20. Structural Components of the Campylobacter jejuni Polar Flagellar Motor
    David R Hendrixson; Fiscal Year: 2013
    ..The stators generate an ion gradient to power the rotor to turn the rod and the filament, which results in swimming motility...
  21. Identification and Characterization of a Novel Regulator of Dopamine Signaling
    DANIEL BERMINGHAM; Fiscal Year: 2013
    ..highly-penetrant, DA signaling-dependent, paralysis phenotype when worms are placed in water, a phenotype we term Swimming- Induced Paralysis (Swip)...
  22. Machine Vision Analysis of C. Elegans Phenotypic Patterns
    Weiwei Zhong; Fiscal Year: 2013
    ..In addition to locomotion on food, we will also score locomotion off food, and both during crawling and swimming. We will cluster the phenotypes to infer genetic modules, and expand these modules using other available genome- ..
  23. Developing Models of Retinal and Eye Defects
    James M Fadool; Fiscal Year: 2010
    ..mosaic patterning of photoreceptor cells through an in situ immunohistochemical screen of the rod mosaic in free swimming, 5 day old larvae...
  24. Direct gas sensing and repellent response to toxic gases in anaerobic pathogens
    Charles W Hespen; Fiscal Year: 2013
    ..sensing is chemotaxis, a two-component signaling pathway responsible for directional change in bacterial swimming. Recently, methyl-accepting chemotaxis proteins (MCP) fused to Heme Nitric oxide/Oxygen (H-NOX) sensor domains ..
    James L Howard; Fiscal Year: 2011
    ..relapse in a rat cocaine self-administration paradigm and significantly decreased immobility and increased swimming time in the forced-swim test (FST) in rats, a test that suggests antidepressant activity...
  26. Mathematical models of membrane biophysics and microbial locomotion
    George F Oster; Fiscal Year: 2013
    ..g. Flavobacteria), and (ii) the swimming of the cyanobacterium, Synechococcus...
  27. Mechanics of Bacterial Swarming
    Howard C Berg; Fiscal Year: 2011
    ..flagella of cells exhibiting such movement and identified a remarkable maneuver wherein cells back up by swimming through the middle of the flagellar bundle, a process promoted by changes in shape of flagellar filaments...
    Jonathan T Pierce-Shimomura; Fiscal Year: 2013
    ..and neuronal ablation, we have found that dopamine release is both necessary and sufficient to transition from swimming to crawling...
  29. Microbial community profiles identify new indicators of waterborne pathogens
    Sandra L McLellan; Fiscal Year: 2013
    ..Human may be exposed to waterborne pathogens through contaminated drinking water or from swimming at contaminated recreational beaches...
  30. Analysis of the shocked zebrafish motility mutant
    Julia Dallman; Fiscal Year: 2009
    ..Preliminary data suggests that excessive electrical coupling underlies the defective swimming phenotype in shocked fish...
  31. Watching a vertebrate brain learn and behave in a virtual environment
    Florian Engert; Fiscal Year: 2013
    ..I propose to establish a fictive swimming assay that allows paralyzed larval zebrafish to navigate through- and interact with a virtual environment...
  32. Watching a vertebrate brain learn and behave in a virtual environment
    Florian Engert; Fiscal Year: 2011
    ..I propose to establish a fictive swimming assay that allows paralyzed larval zebrafish to navigate through- and interact with a virtual environment...
  33. Predictive Modeling of collective swimming in bacterial supensions
    Leonid Berlyand; Fiscal Year: 2013
    Collective swimming -- a highly correlated motion of bacteria -- plays an important role in the life cycle of many bacterial species...
  34. Child health risks attributable to swimming in contaminated water at beaches in t
    John M Colford; Fiscal Year: 2013
    ..Numerous studies have measured swimming-related health risks associated with fecal indicator bacteria exposure in the general population (all ages), but ..
  35. History dependence of chemosensing strategy in Escherichia coli
    Ned S Wingreen; Fiscal Year: 2013
    ..stimulation (via fluorescence resonance energy transfer), and chemotactic behavior (via tracking of single cells swimming in microfluidic gradients)...
  36. Chemical biology of bacterial symbionts
    Jon Clardy; Fiscal Year: 2013
    ..This aim will define the small molecule signal(s) that turns a free-swimming larva into a sessile hydroid...
  37. Determining function of flagellar regulatory protein IC138 in trypanosomes.
    Amy L Springer; Fiscal Year: 2012
    ..Flagellar motility directs swimming in some cell types but can also be critical for proper development or function of tissue such as mammalian kidney,..
  38. "Mechanisms underlying nicotine induced neuronal toxicity in zebrafish"
    Kurt R Svoboda; Fiscal Year: 2011
    ..al, 2002). Embryos acutely exposed to nicotine exhibit a swimming-like behavior at time when they typically do not swim...
  39. Genetic Analysis of Inner Ear Development in tropicalis
    Richard M Harland; Fiscal Year: 2010
    ..This pilot study reveals several loci involved in ear morphology, otolith formation, and balancing/swimming behavior. Importantly, the major events of X...
  40. Control of Locomotor Activity by Identified Premotor Spinal Interneurons
    Mark A Masino; Fiscal Year: 2013
    ..hypotheses in an attempt to progress our understanding of the organization of the spinal network that produces swimming in larval zebrafish...
    John Ruby; Fiscal Year: 1993
    ..denticola's role as a pathogen in oral disease. Spirochete swimming is mediated by the periplasmic flagella (PFs) which reside between the protoplasmic cylinder and outer membrane ..
  42. California Environmental Health Specialist Network (EHS-Net) Food Safety and Wate
    SUSAN ELIZABETH STRONG; Fiscal Year: 2013
    ..Requirements Although good pool operation and maintenance can reduce the incidence of waterborne disease in swimming facilities, even the best maintained pools may be associated with outbreaks...
  43. B.pseudomallei bioterrorism and quorum sensing
    DANIEL HASSETT; Fiscal Year: 2003
    ..A major area of concern is the distribution and survival of pathogenic bacteria in lakes, rivers, streams, swimming pools, our water supply and soils...
  44. V3 Spinal Cord Neurons Participate in Driving Locomotion in Vertebrates
    TIMOTHY DAVID WIGGIN; Fiscal Year: 2013
    ..g., walking, swimming, flying), even in isolation from the brain...
  45. Cone snail venom peptides that modulate zebrafish spinal motor activity
    Joseph Schulz; Fiscal Year: 2009
    ..of this species,c4a causes repetitive firing in motor neurons and disrupts rhythmic motor activity that controls swimming in zebrafish (Danio rerio)...
    Wenyuan Shi; Fiscal Year: 2010
    ..xanthus. Furthermore, these studies could discover the possible evolutionary connections between flagella based swimming motility and TFP dependent gliding motility...
    JOSEPH KIESECKER; Fiscal Year: 2002
    ..The digenetic trematodes, or flukes, are a prominent example whose members usually have free-swimming aquatic forms and whose hosts are often freshwater organisms...
  48. Neural Circulatory Control in the Long QT Syndrome
    Virend Somers; Fiscal Year: 2006
    ..Events in patients with LQT1 occur during exertion, particularly during swimming. Excitement and auditory stimuli typically trigger events in LQT2 patients. Most events in LQT3 occur at rest...
    Barry Bavister; Fiscal Year: 1993
    ..a heat stable factor present in the ovulated cumulus oophorus that facilitates acrosome reactions in free-swimming (i.e., non-zona bound) sperm...
  50. Diffusion of an Effective Skin Cancer Prevention Program
    Karen Glanz; Fiscal Year: 2007
    ..The efficacy of the Pool Cool program in aquatic settings (swimming pools) was demonstrated in a previous trial, and a Dissemination Pilot Study with 186 swimming pools was ..
  51. Photoreceptors Involved in Chlamydomonas reinhardtii Circadian Entrainment
    SIGRID JACOBSHAGEN; Fiscal Year: 2007
    ..The extent of adjustment will be monitored based on the circadian rhythm of phototaxis (swimming towards light) because its measurement has been automated...
    PAUL WASSARMAN; Fiscal Year: 2007
    ..One of the glycoproteins, mZP3, is recognized in a species-specific manner by free-swimming, acrosome-intact sperm when they bind to unfertilized eggs...
    David Nelson; Fiscal Year: 1990
    ..signal transduction by which the ciliated protozoan paramecium tetraurelia responds to stimuli by changing its swimming speed and direction...
  54. Endogenous Opioid Mechanisms Modulating Stress
    JAY MCLAUGHLIN; Fiscal Year: 2006
    ..Mice will be exposed to forced swimming to induce the release of endogenous opioid peptides known to activate kappa opioid receptors...
    Michael Bennett; Fiscal Year: 1991
    The tunicate embryo, which proceeds from fertilization to swimming larva in about 18 hours (in the case of Ciona intestinalis), provides a remarkable preparation for the study of the role of intercellular communication in development...
  56. Modulation of Muscle Activation and Strain in Turtles
    RICHARD BLOB; Fiscal Year: 2001
    ..hindlimb kinematics with hindlimb muscle length changes (strain), as well as activity patterns (EMG), during swimming and walking in turtle species that possess different degrees of specialization for aquatic locomotion...
  57. The contribution of phenotypic variability to chemotactic performance
    Thierry Emonet; Fiscal Year: 2013
    ..An experimental platform recently developed in our lab allows for measurement of the trajectories of swimming cells and the abundance of fluorescently labeled proteins in the same live individual as they navigate controlled ..
  58. Aerotactic Signaling by the Escherichia coli Aer Protein
    John Parkinson; Fiscal Year: 2004
    ..oxygen levels and how that stimulus information is transmitted through the Aer molecule to control the cell's swimming movements...
  59. Behavioral consequences of 5-lipoxygenase deficiency
    Radmila Manev; Fiscal Year: 2007
    ..e., plus maze and marble burying) and depression-like behaviors (forced swimming), suggesting that suppression of 5- LOX may be anxiolytic/antidepressant...
  60. An ATP receptor-operated ionic conductance in Paramecium
    Todd Hennessey; Fiscal Year: 2002
    ..The eukaryotic unicell Paramecium shows ATP-induced behavioral responses (backward swimming), inhibition of these responses by a vertebrate ATP receptor antagonist (PPNDS), ATP-induced depolarizations, ..
    Michael Behbehani; Fiscal Year: 2001
    ..Our recent studies have shown that OI analgesia (OIA) produced by stress of swimming rats in cold water can be blocked by injection of an NT antagonist (SR48692) or by blocking adrenergic receptors...
  62. SP004, a sigma-1 ligand with AchE inhibition properties
    Laurent Lecanu; Fiscal Year: 2004
    ..improve memory impairment in rats and mice, (2) display anti-depressant effects on rats submitted to the forced swimming test, (3) increase the Ach release in rats brain, (4) rescue neuronal cells against excitotoxicity, which ..