running

Summary

Summary: An activity in which the body is propelled by moving the legs rapidly. Running is performed at a moderate to rapid pace and should be differentiated from JOGGING, which is performed at a much slower pace.

Top Publications

  1. pmc Comparison of four ActiGraph accelerometers during walking and running
    Dinesh John
    University of Tennessee, Department of Exercise, Sport, and Leisure Studies, Knoxville, TN 37996 2700, USA
    Med Sci Sports Exerc 42:368-74. 2010
  2. ncbi Enhancing team-sport athlete performance: is altitude training relevant?
    Francois Billaut
    School of Sport and Exercise Science, Institute of Sport, Exercise and Active Living ISEAL, Victoria University, Melbourne, Vic, Australia
    Sports Med 42:751-67. 2012
  3. ncbi Influence of cerebral and muscle oxygenation on repeated-sprint ability
    Kurt J Smith
    Integrative Physiology Unit, University of Lethbridge, Lethbridge, AB, Canada
    Eur J Appl Physiol 109:989-99. 2010
  4. ncbi Motor patterns in human walking and running
    G Cappellini
    Department of Neuromotor Physiology, Scientific Institute Foundation Santa Lucia, 306 via Ardeatina, 00179 Rome, Italy
    J Neurophysiol 95:3426-37. 2006
  5. pmc Significant molecular and systemic adaptations after repeated sprint training in hypoxia
    Raphaël Faiss
    ISSUL Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland
    PLoS ONE 8:e56522. 2013
  6. ncbi High-intensity interval running is perceived to be more enjoyable than moderate-intensity continuous exercise: implications for exercise adherence
    Jonathan D Bartlett
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    J Sports Sci 29:547-53. 2011
  7. pmc Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice
    Michael W Marlatt
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Dev Neurobiol 72:943-52. 2012
  8. pmc Running enhances spatial pattern separation in mice
    David J Creer
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 107:2367-72. 2010
  9. ncbi Computer optimization of a minimal biped model discovers walking and running
    Manoj Srinivasan
    Bio robotics and Locomotion Laboratory, Theoretical and Applied Mechanics, Cornell University, 306 Kimball Hall, Ithaca, New York 14853, USA
    Nature 439:72-5. 2006
  10. ncbi Does 'altitude training' increase exercise performance in elite athletes?
    Carsten Lundby
    Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Br J Sports Med 46:792-5. 2012

Detail Information

Publications398 found, 100 shown here

  1. pmc Comparison of four ActiGraph accelerometers during walking and running
    Dinesh John
    University of Tennessee, Department of Exercise, Sport, and Leisure Studies, Knoxville, TN 37996 2700, USA
    Med Sci Sports Exerc 42:368-74. 2010
    ..Currently, researchers can use the ActiGraph 7164 or one of three different versions of the ActiGraph GT1M to objectively measure physical activity...
  2. ncbi Enhancing team-sport athlete performance: is altitude training relevant?
    Francois Billaut
    School of Sport and Exercise Science, Institute of Sport, Exercise and Active Living ISEAL, Victoria University, Melbourne, Vic, Australia
    Sports Med 42:751-67. 2012
    ..We hope that this will guide the practice of many athletes and stimulate future research to better refine training programmes...
  3. ncbi Influence of cerebral and muscle oxygenation on repeated-sprint ability
    Kurt J Smith
    Integrative Physiology Unit, University of Lethbridge, Lethbridge, AB, Canada
    Eur J Appl Physiol 109:989-99. 2010
    ..By using a hypoxia paradigm, the study suggests that cerebral oxygenation contributes to the impairment of repeated-sprint ability...
  4. ncbi Motor patterns in human walking and running
    G Cappellini
    Department of Neuromotor Physiology, Scientific Institute Foundation Santa Lucia, 306 via Ardeatina, 00179 Rome, Italy
    J Neurophysiol 95:3426-37. 2006
    Despite distinct differences between walking and running, the two types of human locomotion are likely to be controlled by shared pattern-generating networks...
  5. pmc Significant molecular and systemic adaptations after repeated sprint training in hypoxia
    Raphaël Faiss
    ISSUL Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland
    PLoS ONE 8:e56522. 2013
    ..01) in RSH. Our findings show larger improvement in repeated sprint performance in RSH than in RSN with significant molecular adaptations and larger blood perfusion variations in active muscles...
  6. ncbi High-intensity interval running is perceived to be more enjoyable than moderate-intensity continuous exercise: implications for exercise adherence
    Jonathan D Bartlett
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    J Sports Sci 29:547-53. 2011
    ..ratings of perceived enjoyment using the Physical Activity Enjoyment Scale following high-intensity interval running versus moderate-intensity continuous running...
  7. pmc Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice
    Michael W Marlatt
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Dev Neurobiol 72:943-52. 2012
    ..In the present study, 9-month-old female C57Bl/6J mice were housed with or without a running wheel and injected with bromodeoxyuridine (BrdU) to label newborn cells...
  8. pmc Running enhances spatial pattern separation in mice
    David J Creer
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 107:2367-72. 2010
    ..Here, we report that voluntary running enhanced the ability of adult (3 months old) male C57BL/6 mice to discriminate between the locations of two ..
  9. ncbi Computer optimization of a minimal biped model discovers walking and running
    Manoj Srinivasan
    Bio robotics and Locomotion Laboratory, Theoretical and Applied Mechanics, Cornell University, 306 Kimball Hall, Ithaca, New York 14853, USA
    Nature 439:72-5. 2006
    ..Walking feels easiest when going slowly, and running feels easiest when going faster. More unusual gaits seem more tiring...
  10. ncbi Does 'altitude training' increase exercise performance in elite athletes?
    Carsten Lundby
    Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Br J Sports Med 46:792-5. 2012
    ..Another aim is to encourage investigators to design well-controlled studies that will enhance our understanding of the mechanisms and potential benefits of altitude training...
  11. ncbi Straight sprinting is the most frequent action in goal situations in professional football
    Oliver Faude
    Institute of Sports and Preventive Medicine, Saarland University, Saarbrucken, Germany
    J Sports Sci 30:625-31. 2012
    ..In conclusion, straight sprinting is the most frequent action in goal situations. Power and speed abilities are important within decisive situations in professional football and, thus, should be included in fitness testing and training...
  12. ncbi Repeated-sprint ability - part I: factors contributing to fatigue
    Olivier Girard
    Aspetar Qatar Orthopaedic and Sports Medicine Hospital, Research and Education Centre, Doha, Qatar
    Sports Med 41:673-94. 2011
    ..e. running) or a decrease in peak power or total work (i.e. cycling) over sprint repetitions...
  13. ncbi Acute cardiac effects of marathon running
    Justin E Trivax
    Department of Cardiovascular Medicine, William Beaumont Hospital, 3601 W 13 Mile Rd, Royal Oak, MI 48073, USA
    J Appl Physiol (1985) 108:1148-53. 2010
    ..There were no significant arrhythmias. Marathon running causes dilation of the right atrium and right ventricle, reduction of right ventricular ejection fraction, and ..
  14. pmc Age-related changes in 100-km ultra-marathon running performance
    Beat Knechtle
    Facharzt FMH fur Allgemeinmedizin, Gesundheitszentrum St Gallen, Vadianstrasse 26, St Gallen, Switzerland
    Age (Dordr) 34:1033-45. 2012
    ..at the '100 km Lauf Biel' in Switzerland from 1998 to 2010, and (2) to compare the age-related changes in 100-km running performance between males and females. For both sexes, the percent of finishers significantly (P < 0...
  15. pmc A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs
    Dana S Mosher
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 3:e79. 2007
    ..3619; p approximately 0.00028). These results highlight the utility of performance-enhancing polymorphisms, marking the first time a mutation in MSTN has been quantitatively linked to increased athletic performance...
  16. ncbi Energy cost and metabolic power in elite soccer: a new match analysis approach
    Cristian Osgnach
    School of Sport Sciences, University of Udine, Udine, Italy
    Med Sci Sports Exerc 42:170-8. 2010
    ..of professional soccer players, particularly for the identification of "high intensities" considered as "high running speeds." However, accelerations are also essential elements setting metabolic loads, even when speed is low...
  17. pmc Strain screen and haplotype association mapping of wheel running in inbred mouse strains
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina, Charlotte, NC, USA
    J Appl Physiol (1985) 109:623-34. 2010
    ..Specifically, we measured wheel running activity in male and female mice (average age 9 wk) in 41 inbred strains and used activity data from 38 of these ..
  18. ncbi Validity of simple field tests as indicators of match-related physical performance in top-level professional soccer players
    E Rampinini
    Human Performance Lab, Castellanza, Varese, Italy
    Int J Sports Med 28:228-35. 2007
    ..2 +/- 4.5 yrs, mass 80.8 +/- 7.8 kg, and height 181.9 +/- 3.7 cm) completed an incremental running field test to exhaustion, a vertical-jump and a repeated-sprint ability (RSA) test...
  19. ncbi Prolonged repeated-sprint ability is related to arterial O2 desaturation in men
    Francois Billaut
    School of Sport and Exercise Science, Victoria University, Melbourne VIC, Australia
    Int J Sports Physiol Perform 5:197-209. 2010
    ..The ability to repeatedly generate maximum power output is usually accompanied by neuromuscular adjustments...
  20. ncbi Reproducibility of performance changes to simulated live high/train low altitude
    Eileen Y Robertson
    Department of Physiology, Australian Institute of Sport, Canberra, Australia
    Med Sci Sports Exerc 42:394-401. 2010
    ..Elite athletes often undertake multiple altitude exposures within and between training years in an attempt to improve sea level performance...
  21. ncbi Effectiveness of intermittent training in hypoxia combined with live high/train low
    Eileen Y Robertson
    Department of Physiology, Australian Institute of Sport, Canberra, Australia
    Eur J Appl Physiol 110:379-87. 2010
    ..Changes in 3-km time trial performance and physiological measures including VO2max, running economy and haemoglobin mass (Hb(mass)) were assessed. The LH/TL+TH group substantially improved VO2max (4...
  22. ncbi Runners adjust leg stiffness for their first step on a new running surface
    D P Ferris
    Department of Integrative Biology, University of California, Berkeley 94720 3140, USA
    J Biomech 32:787-94. 1999
    Human runners adjust the stiffness of their stance leg to accommodate surface stiffness during steady state running. This adjustment allows runners to maintain similar center of mass movement (e.g...
  23. ncbi Effect of hypoxic "dose" on physiological responses and sea-level performance
    Randall L Wilber
    Athlete Performance Laboratory, United States Olympic Committee, Colorado Springs, CO 80909, USA
    Med Sci Sports Exerc 39:1590-9. 2007
    ..d(-1)...
  24. pmc New neurons generated from running are broadly recruited into neuronal activation associated with three different hippocampus-involved tasks
    Peter J Clark
    Department of Psychology, The Beckman Institute, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Hippocampus 22:1860-7. 2012
    b>Running increases the formation of new neurons in the adult rodent hippocampus. However, the function of new neurons generated from running is currently unknown...
  25. pmc Do older athletes reach limits in their performance during marathon running?
    Romuald Lepers
    INSERM U, Faculty of Sport Sciences, University of Burgundy, Dijon, France
    Age (Dordr) 34:773-81. 2012
    In the last decades, the participation of elderly trained people in endurance events such as marathon running has dramatically increased...
  26. ncbi Effect of a multistage ultra-endurance triathlon on body composition: World Challenge Deca Iron Triathlon 2006
    B Knechtle
    Gesundheitszentrum St Gallen, St Gallen, Switzerland
    Br J Sports Med 42:121-5; discussion 125. 2008
    ..To investigate the effect of a multistage ultra-endurance triathlon on body composition in ultra-triathletes...
  27. ncbi Repeated-sprint ability - part II: recommendations for training
    David Bishop
    Institute of Sport, Exercise and Active Living ISEAL, School of Sport and Exercise Science, Victoria University, Melbourne, Vic, Australia
    Sports Med 41:741-56. 2011
    ..While research has identified a correlation between RSA and total sprint distance during soccer, future studies need to address whether training-induced changes in RSA also produce changes in match physical performance...
  28. ncbi Endurance running and the evolution of Homo
    Dennis M Bramble
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Nature 432:345-52. 2004
    ..Although bipedal gaits include walking and running, running is generally considered to have played no major role in human evolution because humans, like apes, are ..
  29. ncbi "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance
    B D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas 75231, Dallas, Texas 75235, USA
    J Appl Physiol (1985) 83:102-12. 1997
    ..uptake (VO2 max), anaerobic capacity (accumulated O2 deficit), maximal steady state (MSS; ventilatory threshold), running economy, velocity at VO2 max, and blood compartment volumes...
  30. ncbi Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity
    Peter Peeling
    School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, WA, Australia
    Eur J Appl Physiol 106:51-9. 2009
    The effect of two running sessions completed within a 12-h period on hemolysis, inflammation, and hepcidin activity in endurance athletes was investigated...
  31. pmc Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice
    Rachel A Kohman
    Department of Psychology, University of Illinois, Beckman Institute, Urbana, IL 61801 3873, USA
    Brain Behav Immun 26:803-10. 2012
    ..Adult (3.5 months) and aged (18 months) male BALB/c mice were individually housed with or without running wheels for 8 weeks...
  32. ncbi Reliability of time-to-exhaustion versus time-trial running tests in runners
    Paul B Laursen
    School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
    Med Sci Sports Exerc 39:1374-9. 2007
    ..Both time-to-exhaustion (TTE) and time-trial (TT) exercise tests are commonly used to assess exercise performance, but no study has directly examined the reliability of comparable tests in the same subjects...
  33. ncbi The effect of playing formation on high-intensity running and technical profiles in English FA Premier League soccer matches
    Paul S Bradley
    Department of Sports and Exercise, Soccer Research Group, University of Sunderland, Sunderland, UK
    J Sports Sci 29:821-30. 2011
    The aim of this study was to examine the effect of playing formation on high-intensity running and technical performance during elite soccer matches...
  34. ncbi Increased shelterin mRNA expression in peripheral blood mononuclear cells and skeletal muscle following an ultra-long-distance running event
    Matthew J Laye
    The Center of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Center, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 112:773-81. 2012
    ..We have provided the first evidence that, in humans, proteins within and associated with the shelterin complex increase at the mRNA level in response to a physiological stress differentially in PBMCs and skeletal muscle...
  35. ncbi Analysis of repeated high-intensity running performance in professional soccer
    Christopher Carling
    LOSC Lille Metropole Football Club, Camphin en Pevele, France
    J Sports Sci 30:325-36. 2012
    ..High-intensity running performance (movement at velocities >19...
  36. ncbi Failed excitability of spinal motoneurons induced by prolonged running exercise
    S Racinais
    Faculté des Sciences du Sports, Laboratoire EA 2991, Efficience et Déficience Motrices, Universite de Montpellier 1, 700 Avenue du Pic Saint Loup, 34090 Montpellier, France
    J Neurophysiol 97:596-603. 2007
    ..The second purpose was to compare the development of central fatigue between continuous and intermittent running modes...
  37. ncbi Physiological and metabolic responses of repeated-sprint activities:specific to field-based team sports
    Matt Spencer
    Team Sport Research Group, School of Human Movement and Exercise Science, The University of Western Australia, Crawley, Western Australia, Australia
    Sports Med 35:1025-44. 2005
    ..Assessment of RSA, as a training and research tool, is also discussed...
  38. ncbi Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle
    Jonathan D Bartlett
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
    J Appl Physiol (1985) 112:1135-43. 2012
    The aim of the present study was to test the hypothesis that acute high-intensity interval (HIT) running induces greater activation of signaling pathways associated with mitochondrial biogenesis compared with moderate-intensity ..
  39. ncbi Cardiac arrest during long-distance running races
    Jonathan H Kim
    Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 366:130-40. 2012
    Approximately 2 million people participate in long-distance running races in the United States annually. Reports of race-related cardiac arrests have generated concern about the safety of this activity.
  40. ncbi Effects of weather on the performance of marathon runners
    Timo Vihma
    Finnish Meteorological Institute, PO Box 503, 00101 Helsinki, Finland
    Int J Biometeorol 54:297-306. 2010
    ..7 h. Effects of warm weather were less evident for female than male runners, which was probably partly due to female runners' larger ratio of surface area to body mass and slower running speed.
  41. ncbi Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise
    Jurgen Scharhag
    Institute of Sports and Preventive Medicine, University of Saarland, Saarbrücken Homburg, Germany
    Am Heart J 150:1128-34. 2005
    ....
  42. ncbi Physiological regulation of marathon performance
    Edward F Coyle
    Department of Kinesiology and Health Education, University of Texas at Austin, Austin, Texas 78712, USA
    Sports Med 37:306-11. 2007
    b>Running a marathon at the fastest speed possible appears to be regulated by the rate of aerobic metabolism (i.e. marathon oxygen uptake) of a limited amount of carbohydrate energy (i.e...
  43. ncbi Can neuromuscular fatigue explain running strategies and performance in ultra-marathons?: the flush model
    Guillaume Y Millet
    Universite de Lyon, and Laboratoire dePhysiologie de l Exercice EA 4338, Médecine du Sport Myologie, Hopital Bellevue, F 42023, Saint Etienne, France
    Sports Med 41:489-506. 2011
    While the industrialized world adopts a largely sedentary lifestyle, ultra-marathon running races have become increasingly popular in the last few years in many countries...
  44. ncbi Biomechanical factors associated with tibial stress fracture in female runners
    Clare E Milner
    Department of Physical Therapy, University of Delaware, Newark, DE 19716, USA
    Med Sci Sports Exerc 38:323-8. 2006
    Tibial stress fractures (TSF) are among the most serious running injuries, typically requiring 6-8 wk for recovery...
  45. ncbi Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in mice
    D M Thomson
    Dept of Physiology and Developmental Biology, Brigham Young Univ, Provo, UT 84602, USA
    Am J Physiol Endocrinol Metab 292:E196-202. 2007
    ..The LKB1KO mice had difficulty running on the treadmill and exhibited marked reduction in distance run in voluntary running wheels over a 3-wk period (5...
  46. ncbi Distance running in hot environments: a thermal challenge to the elite runner
    R J Maughan
    School of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire LE11 3TU, UK
    Scand J Med Sci Sports 20:95-102. 2010
    ..There is growing evidence that the effects of high ambient temperature and dehydration on performance of exercise may be mediated by effects on the central nervous system. This seems to involve serotonergic and dopaminergic functions...
  47. pmc Muscle contributions to propulsion and support during running
    Samuel R Hamner
    Department of Mechanical Engineering, Stanford University, Stanford, CA 94305 5450, USA
    J Biomech 43:2709-16. 2010
    Muscles actuate running by developing forces that propel the body forward while supporting the body's weight. To understand how muscles contribute to propulsion (i.e., forward acceleration of the mass center) and support (i.e...
  48. ncbi Effect of anti-inflammatory medication on the running-induced rise in patella tendon collagen synthesis in humans
    Britt Christensen
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, and Center of Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 110:137-41. 2011
    ..Both groups were exposed to a prolonged bout of running (36 km)...
  49. ncbi The antidepressant effect of running is associated with increased hippocampal cell proliferation
    Astrid Bjørnebekk
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Int J Neuropsychopharmacol 8:357-68. 2005
    ..In order to identify possible biological underpinnings of depression and the antidepressant effect of running, we analysed cell proliferation, the level of the neurotrophic factor BDNF in hippocampus and dynorphin in ..
  50. ncbi High impact running improves learning
    Bernward Winter
    Department of Neurology, University of Muenster, Muenster, Germany
    Neurobiol Learn Mem 87:597-609. 2007
    ..Learning performance was assessed directly after high impact anaerobic sprints, low impact aerobic running, or a period of rest in 27 healthy subjects in a randomized cross-over design...
  51. pmc Running is the neurogenic and neurotrophic stimulus in environmental enrichment
    Tali Kobilo
    Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, Maryland 21224, USA
    Learn Mem 18:605-9. 2011
    ..However, running is considered an element of EE...
  52. ncbi Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in relation to running distance in a marathon (42.195 km) and an ultra-marathon (200 km) race
    Hyo Jeong Kim
    Human Physiology, Korea National Sport University, Olympic Park, 88 15 Oryun dong, Songpa Gu, Seoul, South Korea
    Eur J Appl Physiol 105:765-70. 2009
    Marathon running is frequently associated with numerous cellular changes, but little information is available on the effects of exercise-mediated prolonged impact-stress on cartilage integrity...
  53. ncbi Acute first-time hamstring strains during high-speed running: a longitudinal study including clinical and magnetic resonance imaging findings
    Carl M Askling
    Swedish School of Sport and Health Sciences, Stockholm, Sweden
    Am J Sports Med 35:197-206. 2007
    ..Hamstring muscle strain is one of the most common injuries in sports. Still, knowledge is limited about the progression of clinical and magnetic resonance imaging characteristics and their association with recovery time in athletes...
  54. ncbi Do gender differences in running performance disappear with distance?
    J Richard Coast
    Department of Exercise Science, Northern Arizona University, Flagstaff, AZ 86001 5092, USA
    Can J Appl Physiol 29:139-45. 2004
    It has been suggested that gender differences in running should disappear as distances increase, particularly past the marathon...
  55. ncbi Running springs: speed and animal size
    C T Farley
    Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138
    J Exp Biol 185:71-86. 1993
    ..The length of time that the feet are in contact with the ground increases with body mass in nearly the same way as the resonant period of vertical vibration...
  56. ncbi Muscle and blood metabolites during a soccer game: implications for sprint performance
    Peter Krustrup
    Institute of Exercise and Sport Sciences, Department of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    Med Sci Sports Exerc 38:1165-74. 2006
    ..To examine muscle and blood metabolites during soccer match play and relate it to possible changes in sprint performance...
  57. pmc Changes in muscle T2 and tissue damage after downhill running in mdx mice
    Sunita Mathur
    Department of Physical Therapy, University of Florida, Gainesville, Florida, USA
    Muscle Nerve 43:878-86. 2011
    In this study we compared the effects of downhill or horizontal treadmill running on the magnetic resonance imaging (MRI) transverse relaxation time constant (T(2)) in mdx mice.
  58. ncbi Variation in top level soccer match performance
    E Rampinini
    Human Performance Laboratory, S S MAPEI srl, Castellanza, Italy
    Int J Sports Med 28:1018-24. 2007
    ..Match activities (standing, walking, jogging, running, high-speed running and sprinting), distances (total distance [TD], high-intensity running [HIR] and very high-..
  59. ncbi Historical analysis of participation in 161 km ultramarathons in North America
    Martin D Hoffman
    Department of Veterans Affaris, Northern California Health Care System, and University of California Davis Medical Center, Sacramento
    Int J Hist Sport 27:1877-91. 2010
    Participation trends in 100 m (161 km) ultramarathon running competitions in North America were examined from race results from 1977 through 2008. A total of 32, 352 finishes accounted for by 9815 unique individuals were identified...
  60. pmc The Western States 100-Mile Endurance Run: participation and performance trends
    Martin D Hoffman
    Department of Physical Medicine and Rehabilitation, Department of Veterans Affairs, Northern California Health Care System, and University of California Davis Medical Center, Sacramento, CA, USA
    Med Sci Sports Exerc 41:2191-8. 2009
    ..Examine changes in demographics of participants and performance trends at the Western States 100-Mile Endurance Run (WSER) since its inception in 1974...
  61. ncbi Maximal lactate steady state in running mice: effect of exercise training
    Julio C B Ferreira
    School of Physical Education and Sport, Department of Biodynamics, University of Sao Paulo, Sao Paulo, Brazil
    Clin Exp Pharmacol Physiol 34:760-5. 2007
    ..The present study was undertaken to determine MLSSw and MLSSc in running mice. In addition, we provide an exercise training protocol for mice based on MLSSw. 2...
  62. pmc Running induces widespread structural alterations in the hippocampus and entorhinal cortex
    Alexis M Stranahan
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Hippocampus 17:1017-22. 2007
    ..Using Golgi impregnation and the lipophilic tracer DiI, we show that long-term voluntary running increases the density of dendritic spines in the entorhinal cortex and hippocampus of adult rats...
  63. ncbi Artificial selection for intrinsic aerobic endurance running capacity in rats
    L G Koch
    Functional Genomics Laboratory, Medical College of Ohio, Toledo, Ohio 43614 5804, USA
    Physiol Genomics 5:45-52. 2001
    Artificial selection for intrinsic aerobic endurance running capacity was started using genetically heterogeneous N:NIH stock of rats as a founder population (n = 168)...
  64. pmc Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain
    Andrew S Naylor
    Center for Brain Repair and Rehabilitation, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30, Sweden
    Proc Natl Acad Sci U S A 105:14632-7. 2008
    ..C57/BL6 mice on postnatal day 9 and evaluated both the acute effects of irradiation and the effects of voluntary running on hippocampal neurogenesis and behavior 3 months after irradiation...
  65. ncbi Impact of weather on marathon-running performance
    Matthew R Ely
    U S Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
    Med Sci Sports Exerc 39:487-93. 2007
    Marathon running performance slows in warm weather conditions, but the quantitative impact of weather has not been established.
  66. ncbi Repeated-sprint performance and vastus lateralis oxygenation: effect of limited O₂ availability
    F Billaut
    Institut national du sport du Québec, Montreal, Canada
    Scand J Med Sci Sports 23:e185-93. 2013
    ..These results extend previous findings that muscle O2 availability is important for prolonged repeated-sprint performance, in particular when the exercise is taken in hypoxia...
  67. pmc Removal of movement artifact from high-density EEG recorded during walking and running
    Joseph T Gwin
    Human Neuromechanics Laboratory, School of Kinesiology University of Michigan, Ann Arbor, Michigan, USA
    J Neurophysiol 103:3526-34. 2010
    ..spatial filtering approach to remove gait-related movement artifact from EEG signals recorded during walking and running. We first used stride time warping to remove gait artifact from high-density EEG recorded during a visual oddball ..
  68. pmc Running stability is enhanced by a proximo-distal gradient in joint neuromechanical control
    M A Daley
    Concord Field Station, MCZ, Harvard University, 100 Old Causeway Road, Bedford, MA 01730, USA
    J Exp Biol 210:383-94. 2007
    We currently know little about how animals achieve dynamic stability when running over uneven and unpredictable terrain, often characteristic of their natural environment...
  69. ncbi Shoe midsole hardness, sex and age effects on lower extremity kinematics during running
    Benno M Nigg
    Human Performance Laboratory HPL, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada
    J Biomech 45:1692-7. 2012
    Previous studies investigating the effects of shoe midsole hardness on running kinematics have often used male subjects from within a narrow age range...
  70. ncbi Children's OMNI Scale of Perceived Exertion: walking/running evaluation
    Alan C Utter
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 34:139-44. 2002
    ..The Children's OMNI-walk/run Scale of Perceived Exertion (category range, 0-10) was evaluated using male and female children (6-13 yr of age) during a treadmill graded exercise test...
  71. ncbi Predictors of running-related injuries in novice runners enrolled in a systematic training program: a prospective cohort study
    Ida Buist
    University Center for Sport, Exercise and Health, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Sports Med 38:273-80. 2010
    The popularity of running is still growing. As participation increases, running-related injuries also increase. Until now, little is known about the predictors for injuries in novice runners.
  72. ncbi Validity and reliability of GPS for measuring instantaneous velocity during acceleration, deceleration, and constant motion
    Matthew C Varley
    Institute of Sport, Exercise and Active Living, Victoria University, Melbourne, Victoria, Australia
    J Sports Sci 30:121-7. 2012
    ..for measuring instantaneous velocity during acceleration, deceleration, and constant velocity while straight-line running. Three participants performed 80 running trials while wearing two GPS units each (5 Hz, V2.0 and 10 Hz, V4...
  73. ncbi Physiological strain associated with high-intensity hypoxic intervals in highly trained young runners
    Martin Buchheit
    Sport Science Department, ASPIRE Academy for Sports Excellence, Doha, Qatar
    J Strength Cond Res 26:94-105. 2012
    ..The present results also confirm that HHIT may not be optimal for training both the cardiorespiratory and neuromuscular determinants of running performance in this population.
  74. ncbi Running, breathing and visceral motion in the domestic rabbit (Oryctolagus cuniculus): testing visceral displacement hypotheses
    R S Simons
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Biol 202:563-77. 1999
    The relative motion of the visceral mass may be important to ventilation during running. A visceral piston hypothesis predicts that, during galloping, cranial motion of the liver during expiration and caudal motion of the liver during ..
  75. ncbi Manipulating high-intensity interval training: effects on VO2max, the lactate threshold and 3000 m running performance in moderately trained males
    Fahimeh Esfarjani
    School of Science and Physical Education, Esfahan University, Esfahan, Iran
    J Sci Med Sport 10:27-35. 2007
    ..VO(2max)), the lactate threshold (LT) and 3000 m running performance in moderately trained male runners. .VO(2max), the running speed associated with .VO(2max) (V...
  76. pmc The role of intrinsic muscle mechanics in the neuromuscular control of stable running in the guinea fowl
    Monica A Daley
    Structure and Motion Laboratory, Royal Veterinary College, University of London, Hatfield, Hertfordshire, UK
    J Physiol 587:2693-707. 2009
    ..the interplay between intrinsic mechanical and neural factors in muscle contractile performance during running, which has been less studied than during walking...
  77. pmc The effects of exercise and stress on the survival and maturation of adult-generated granule cells
    Jason S Snyder
    Unit on Neuroplasticity, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hippocampus 19:898-906. 2009
    Stress strongly inhibits proliferation of granule cell precursors in the adult dentate gyrus, whereas voluntary running has the opposite effect...
  78. pmc Vigorous exercise, fitness and incident hypertension, high cholesterol, and diabetes
    Paul T Williams
    Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Med Sci Sports Exerc 40:998-1006. 2008
    ..Analyses were undertaken to determine the dose-response relationships of fitness to incident hypertension, hypercholesterolemia, and diabetes independent of activity...
  79. ncbi Changes in spring-mass model characteristics during repeated running sprints
    Olivier Girard
    Research and Education Centre, ASPETAR, Qatar Orthopaedic and Sports Medicine Hospital, PO Box 29222, Doha, Qatar
    Eur J Appl Physiol 111:125-34. 2011
    This study investigated fatigue-induced changes in spring-mass model characteristics during repeated running sprints. Sixteen active subjects performed 12 × 40 m sprints interspersed with 30 s of passive recovery...
  80. pmc Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running
    K Ostrowski
    The Copenhagen Muscle Research Centre, Department of Infectious Diseases, Rigshospitalet, Section 7652, Tagensvej 20, DK 2200 Copenhagen N, Denmark
    J Physiol 508:949-53. 1998
    ..4. This study suggests that exercise-induced destruction of muscle fibres in skeletal muscles may trigger local production of IL-6, which stimulates the production of IL-1ra from circulating BMNC...
  81. ncbi Increased high-intensity activity in elite Australian football finals matches
    Robert J Aughey
    Institute of Sport, Exercise and Active Living, Victoria University, Melbourne, Australia
    Int J Sports Physiol Perform 6:367-79. 2011
    ..intermittent sport, requiring athletes to accelerate hundreds of times with repeated bouts of high-intensity running (HIR)...
  82. ncbi Validation of the Adult OMNI Scale of perceived exertion for walking/running exercise
    Alan C Utter
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA
    Med Sci Sports Exerc 36:1776-80. 2004
    ..Concurrent and construct validity of the OMNI-Walk/Run Scale of Perceived Exertion was examined using young adult women and men (18-36 yr)...
  83. pmc Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation
    Sarah J E Wong-Goodrich
    Department of Psychology and Neuroscience, Duke University, Durham, North Carolina 27708, USA
    Cancer Res 70:9329-38. 2010
    ..the short- and long-term effects of WBI on spatial learning and memory retention and determined whether voluntary running after WBI aids recovery of brain and cognitive function...
  84. ncbi Voluntary dehydration in runners despite favorable conditions for fluid intake
    Dennis Passe
    Gatorade Sports Science Institute, Barrington, IL 60010, USA
    Int J Sport Nutr Exerc Metab 17:284-95. 2007
    ....
  85. ncbi Physiological and biological factors associated with a 24 h treadmill ultra-marathon performance
    G Y Millet
    Exercise Physiology Laboratory, Jean Monnet University, Saint Etienne, France
    Scand J Med Sci Sports 21:54-61. 2011
    ..Maximal oxygen uptake (VO(2max)), velocity associated with VO(2max)(VO(2max)) and running economy (RE) at 8 km/h were measured. A muscle biopsy was also performed in the vastus lateralis muscle...
  86. ncbi Athletic experience influences shoulder rotations when running through apertures
    Takahiro Higuchi
    Department of Health Promotion Science, Graduate School of Human Health Science, Tokyo Metropolitan University, Hachioji, Tokyo, Japan
    Hum Mov Sci 30:534-49. 2011
    ..The present study investigated whether athletes who have extensive experience playing sports that require running through narrow spaces while wearing shoulder pads control their shoulder rotations differently while performing ..
  87. pmc The TransEurope FootRace Project: longitudinal data acquisition in a cluster randomized mobile MRI observational cohort study on 44 endurance runners at a 64-stage 4,486 km transcontinental ultramarathon
    Uwe H W Schütz
    Department of Diagnostic and Interventional Radiology, University Hospital of Ulm, Germany
    BMC Med 10:78. 2012
    ..2009 (TEFR09) was one of the longest transcontinental ultramarathons with an extreme endurance physical load of running nearly 4,500 km in 64 days...
  88. ncbi Upregulation of circulating IL-15 by treadmill running in healthy individuals: is IL-15 an endocrine mediator of the beneficial effects of endurance exercise?
    Yoshiaki Tamura
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Charlestown, MA 02129, USA
    Endocr J 58:211-5. 2011
    ..Here, we show that in opposition to previous findings, 30-min treadmill running at 70% of age-predicted maximum heart rate resulted in a significant increase in circulating IL-15 level in ..
  89. ncbi Magnetic resonance imaging of myocardial injury and ventricular torsion after marathon running
    Henner Hanssen
    Department of Prevention and Sports Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Clin Sci (Lond) 120:143-52. 2011
    ..Although marathon running leads to a transient increase of cardiac biomarkers, no detectable myocardial necrosis was observed as evidenced ..
  90. ncbi Changes in total body water content during running races of 21.1 km and 56 km in athletes drinking ad libitum
    Nicholas Tam
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, Western Cape, South Africa
    Clin J Sport Med 21:218-25. 2011
    ..To measure changes in body mass (BM), total body water (TBW), fluid intake, and blood biochemistry in athletes during 21.1-km and 56-km foot races...
  91. ncbi Running performance differences between men and women:an update
    Samuel N Cheuvront
    US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
    Sports Med 35:1017-24. 2005
    ..More than a decade ago it was reported in the journal Nature that the slope of improvement in the men's and women's running records, extrapolated from mean running velocity plotted against historical time, would eventually result in a ..
  92. ncbi Uphill running improves rat Achilles tendon tissue mechanical properties and alters gene expression without inducing pathological changes
    K M Heinemeier
    Institute of Sports Medicine, Department of Orthopedic Surgery M81, Bispebjerg Hospital and Centre of Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 113:827-36. 2012
    ..02) in runners compared with controls further supported that tendons successfully adapted to uphill running. Several genes of interest were regulated after 12 wk of running...
  93. pmc Impact of environmental parameters on marathon running performance
    Nour El Helou
    IRMES bioMedical Research Institute of Sports Epidemiology, INSEP, Paris, France
    PLoS ONE 7:e37407. 2012
    ..The objectives of this study were to describe the distribution of all runners' performances in the largest marathons worldwide and to determine which environmental parameters have the maximal impact...
  94. ncbi Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon
    Tomas G Neilan
    Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02115 2696, USA
    Circulation 114:2325-33. 2006
    ....
  95. ncbi Running has differential effects on NPY, opiates, and cell proliferation in an animal model of depression and controls
    Astrid Bjørnebekk
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 31:256-64. 2006
    ..Recently, we found an antidepressant-like effect of running in an animal model of depression, the Flinders Sensitive Line (FSL) and demonstrated that it was associated with ..
  96. ncbi Single muscle fiber contractile properties of young competitive distance runners
    Matthew Harber
    Human Performance Laboratory, Ball State University, Muncie, IN 47306, USA
    J Appl Physiol (1985) 105:629-36. 2008
    ..These characteristics of the fast-twitch muscle fibers have not been previously reported in competitive endurance athletes and may contribute to the high level of running performance in these athletes.
  97. ncbi Effect of carbohydrate intake on half-marathon performance of well-trained runners
    Louise M Burke
    Dept of Sports Nutrition, Australian Institute of Sport, Belconnen, ACT, Australia
    Int J Sport Nutr Exerc Metab 15:573-89. 2005
    ..Although benefits to half marathon performance were not detected, the theoretical improvement during 1-h exercise with CHO intake merits further investigation...
  98. ncbi Maximal strength training improves running economy in distance runners
    Oyvind Støren
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Med Sci Sports Exerc 40:1087-92. 2008
    The present study investigated the effect of maximal strength training on running economy (RE) at 70% of maximal oxygen consumption (V[spacing dot above]O2max) and time to exhaustion at maximal aerobic speed (MAS)...
  99. ncbi Acute changes in endocrine and fluid balance markers during high-intensity, steady-state, and prolonged endurance running: unexpected increases in oxytocin and brain natriuretic peptide during exercise
    Tamara Hew-Butler
    University of Cape Town, Cape Town, 7725 South Africa
    Eur J Endocrinol 159:729-37. 2008
    ..Seven endurance-trained runners completed three separate running trials: a maximal test to exhaustion (high intensity), a 60-min treadmill run (steady state), and a 56 km ..
  100. ncbi Hormonal responses to a 160-km race across frozen Alaska
    W J Kraemer
    University of Connecticut, Human Performance Laboratory, Storrs, Connecticut 06269 1110, USA
    Br J Sports Med 42:116-20; discussion 120. 2008
    ..Examining hormonal responses to an extreme 160-km competition across frozen Alaska provides a unique opportunity to study this intense stress...
  101. ncbi Validity and reliability of GPS devices for measuring movement demands of team sports
    Aaron J Coutts
    School of Leisure, Sport and Tourism, University of Technology Sydney, Australia
    J Sci Med Sport 13:133-5. 2010
    ..Performance measures were: (1) total distance covered for each bout and each lap; (2) high-intensity running distance (>14.4 km h(-1), HIR); very high-intensity running distance (>20 km h(-1), VHIR) during each bout...

Research Grants77

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2013
    ..My overall career goal is to become a fully independent scientist running a laboratory dedicated to answering fundamental biological questions aimed at human health and disease...
  3. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..However, there have been no studies evaluating the health effects of exposure to emissions from equipment running on diesel fuel as compared with a biodiesel blend, and some in vitro studies suggest greater toxicity from ..
  4. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..will establish test's performance criteria (optimal sampling preparation, preservation, storage &running conditions) to ensure that the assay will perform the same way in any Lab., by any trained personnel...
  5. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..To this end we have built custom cages with sensors in running wheels and cameras which track infrared light emitters in the implanted pumps, allowing us to determine ..
  6. Overcoming Temozolomide Resistance using MGMT-targeting Spherical Nucleic Acids
    TIMOTHY L SITA; Fiscal Year: 2013
    ..Prior to running in vivo experiments, we will establish a relationship between MGMT, TMZ, and cell death in our TNS cultures...
  7. SYSTEM FOR AUTOMATED NONINVASIVE MONITORING OF MOUSE SLEEP AND BEHAVIOR
    Sridhar Sunderam; Fiscal Year: 2013
    ..Behavioral monitoring of mice is usually limited to actigraphic measurements such as video tracking, wheel-running, and photoelectric beam-breaking...
  8. Protein composition and interactions of telemeric chromatin
    Michael P Killoran; Fiscal Year: 2010
    ..Once these new approaches are up and running, I plan to apply them in my own research program to ask questions of how telomere structure/composition changes ..
  9. Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null Mic
    Yuqing Li; Fiscal Year: 2010
    ..In addition, the mutant mice will be tested in cages with free access running wheels that are ported to a computer...
  10. Characterizing Ankle Function During Sloped Locomotion For Prosthesis Development
    Alena Grabowski; Fiscal Year: 2012
    ..The proposed Career Development Award aims to characterize biological ankle joint function during walking and running on slopes in order to further develop advanced powered ankle-foot prostheses...
  11. Endothelial Cell Dysregulation in Neovascular AMD
    Mark E Kleinman; Fiscal Year: 2013
    ..The candidate aims to have an independent laboratory up and running within the initial 12-18 months of the award period in order to gain early independence with his research project ..
  12. TOLLIP and Tuberculosis Immunopathogenesis
    JAVEED ALI SHAH; Fiscal Year: 2013
    ..at an academic center, develop sources of independent research funding, and devote >75% of his time to running a lab and collaborative clinical studies...
  13. A dataset for the study of the social determinants of health.
    Peter A Muennig; Fiscal Year: 2010
    ..We propose to link over thirty years of data from the longest running social science dataset to mortality data, creating the first major prospective sociomedical dataset...
  14. The Toxic Environment and the Epigenetics of Fetal Growth
    HEATHER HERSON BURRIS; Fiscal Year: 2013
    ..administrative skills needed to manage a large cohort study so that transition to an independent research career running her own birth cohort is accomplished...
  15. The role fo the TPP1 peotein in telomerase function and cancer cell survival
    Jayakrishnan Nandakumar; Fiscal Year: 2013
    ..In the long-term, I wish to become an independent investigator, running a lab consisting of people from various backgrounds (biochemistry, structural biology, and cell biology) working ..
  16. Protein Phosphatase Regulation of the Principal Renal Sodium Transporter NHE3
    Ion Alexandru Bobulescu; Fiscal Year: 2013
    ..b>Running a research laboratory, managing and nurturing people, fostering collaborations, being an effective mentor and ..
  17. Inhibitors of the ENT4 Adenosine Transporter for Cardioprotection
    John K Buolamwini; Fiscal Year: 2010
    ..the number one cause of death in the Nation, claiming the lives of nearly one million Americans each year, and running up medical costs estimated at $286.5 billion per year...
  18. Novel CNS Target for Sleep-Wake and Psychiatric Disorders
    SCOTT MCNEAR THACHER; Fiscal Year: 2010
    ..In Aim 2, we characterize circadian phase shifting by short-term exposure to ligand in mice free running on a 24 h period in the dark, a classic test of a potential chronotherapeutic...
  19. Separation-of-function Mutants to Study the Biological Significance of Telomerase
    Jayakrishnan Nandakumar; Fiscal Year: 2012
    ..In the long-term, I wish to become an independent investigator, running a lab consisting of people from various backgrounds (biochemistry, structural biology, and cell biology) working ..
  20. Metabolic flux in a model of reduced oxidative capacity
    CHARLES ROBERT EVANS; Fiscal Year: 2013
    ..quantitative targeted metabolomic assays will be performed in skeletal muscle and plasma of LCR and HCR running rats at rest and during exercise...
  21. A Protein Biologic for the Treatment of Sepsis
    Rafal M Smigrodzki; Fiscal Year: 2010
    ..Behaviorally, healthy mice treated with rhTFAM increased running endurance (rotarod latency) by 300%, and there were no significant side-effects over up to 10 months of dosing ..
  22. CHEMOPREVENTION OF SKIN CANCER PROGRAM PROJECT
    George Timothy Bowden; Fiscal Year: 2013
    ..While this PPG will not take on the task of delivery by running phase III clinical trials, progress of earlier agents discovered and developed previously by the investigators ..
  23. STRUCTURAL STUDIES OF NUCLEOPROTEIN COMPLEXES
    Edward H Egelman; Fiscal Year: 2012
    This long running project has been focused on nucleoprotein complexes active in DNA recombination and replication. The main tools that we have been using are electron microscopy and computational image analysis...
  24. NIH Director's Pioneer Award
    Karl Deisseroth; Fiscal Year: 2009
    ..abstract_text> ..
  25. Muscle viscosity as a protective mechanism for absorbing mechanical shock
    Armen Sarvazyan; Fiscal Year: 2013
    ..shock in time and space and unload skeletal joints is of key importance in physical activities, such as running and jumping, playing soccer, wrestling, etc...
  26. Biology of Aerobic Capacity and Insulin Resistance
    Charles F Burant; Fiscal Year: 2012
    ..heterogeneous colony of rats with inherited differences in oxidative capacity base on low (LCR) and high (HCR) running capacity show differences in the propensity to develop a phenotype consistent with the 'metabolic syndrome&..
  27. Role of 12/15-lipoxygenase in mechanisms of muscle atrophy during aging
    Arunabh Bhattacharya; Fiscal Year: 2013
    ..is designed to provide valuable experience in other aspects of research including managing a research budget, running a laboratory independently, forging collaborations and writing grant applications to national funding agencies ..
  28. Screening for allosteric modulators of the protease activated receptor 4
    Heidi E Hamm; Fiscal Year: 2013
    ..on Vanderbilt's many successes in generating novel ligands that target the allosteric sites of GPCRs by running a triple add HTS screen, 2) we will identify compounds which inhibit thrombin stimulation of PAR4 and are ..
  29. Effect of Articular Neurotoxin on Joint Pain and Neurochemical Signature
    Maren Lawson Mahowald; Fiscal Year: 2012
    ..measure arthritis pain behaviors by observing and quantifying spontaneous pain behaviors such as nocturnal wheel-running and spontaneous nocturnal activity, as well as induced behaviors such as vocalizations, biting and fighting the ..
  30. Health benefits of vigorous exercise in middle-aged versus older men and women
    Paul T Williams; Fiscal Year: 2010
    ..The study was initiated in 1991 through recruitment at foot race events and through solicitation of running magazine subscribers...
  31. Genomewide Determinants Of Prognosis And Treatment Of Early-Onset Breast Cancer
    Habibul Ahsan; Fiscal Year: 2010
    ..we will characterize and validate the function and molecular basis of the effects of the prognostic alleles, by running whole genome gene expression, microRNA expression and methylation profiles in tumor tissues for 200 breast cancer ..
  32. Maternal Overweight: Consequences for Insulin Signaling in the Offspring
    Kartik Shankar; Fiscal Year: 2013
    ..prior to conception as an intervention and will test the hypothesis that increased physical activity (treadmill running) in the OW dams prior to conception will improve offspring insulin sensitivity and mitigate increased adipose ..
  33. Intermediate Filaments & Costamere Structure & Function
    Robert J Bloch; Fiscal Year: 2010
    ..In Aim 2, we will characterize the contractile activity, running ability, and susceptibility to eccentric injury of the individual mutants and the DKO...
  34. Defining the role of mast cells during influenza A virus infection
    Joshua J Obar; Fiscal Year: 2012
    ..to a 10-color BD LSRII cytometer, a g-cell irradiator for making bone marrow chimeras, and BioPlex200 machine for running Luminex plates...
  35. PHYSIOLOGICAL DISSECTION OF THE SCN
    Rae Silver; Fiscal Year: 2010
    ..testicular hormones play a major role in regulating locomotor activity;gonadectomy produces a lengthening of free-running period, a loss of precision and complete loss of the daily activity onset bout...
  36. Maternal Exercise Protects Offspring from Obesity and Insulin Resistance
    KEVIN JOSEPH PEARSON; Fiscal Year: 2013
    ..The exercise dams will have 24 hour access to running wheels before mating and throughout pregnancy and nursing...
  37. Cortical Synapses and Psychosis in AD
    Robert A Sweet; Fiscal Year: 2012
    ..4400 with dual 733 MHz Xeon processors Novell Server, used for maintaining the database of brain specimens and running the web server. It is also used as the file server...
  38. RESOURCE FOR RAT GENETIC MODELS OF AEROBIC CAPACITY
    Steven Loyal Britton; Fiscal Year: 2013
    ..of low capacity runners (LCR) and high capacity runners (HCR) that differ by over 5-fold in aerobic treadmill running capacity...
  39. Durable CD4+ T-cell Tumor Immunity Following Gene-modified HPSC
    Christopher E Touloukian; Fiscal Year: 2013
    ..Over the past 25 years, cancer immunotherapy has undergone tremendous innovation and progress with developments running parallel to advances in basic immunology, molecular genetics and gene therapy...
  40. Genetics and biology of a viable mutant mouse with dystonic movements
    Kathleen J Sweadner; Fiscal Year: 2013
    ..Although the symptoms are severe, a key feature is that the mice are capable of normal walking and running on a wheel, functions that are largely mediated by spinal pattern generators and spinal sensorimotor integration...
  41. Rapid-onset Dystonia Parkinsonism (DYT12 Dystonia): Pathophysiology &Atp1a3 Mice
    Yuqing Li; Fiscal Year: 2011
    ..to distinguish from behaviorally penetrant and non-penetrant Atp1a3 mutant mice using a novel voluntary wheel running paradigm...
  42. Brain Tumor-Penetrating Nanoparticle Delivery with MR-Guided Focused Ultrasound
    Richard J Price; Fiscal Year: 2013
    ..In Aim 2, running in parallel with Aim 1, we will determine FUS pressure thresholds for safe and reversible MR-guided BBB opening ..
  43. Myostatin Regulation of Skeletal Muscle Energy Metabolism
    SUZANNE PORSZASZ-REISZ; Fiscal Year: 2013
    ..Outcomes will include: force-velocity relationship, maximal exercise tolerance as measured by VO2max, maximal running speed and the endurance will be characterized by the running speed- endurance curves, as well as mitochondrial ..
  44. Whole Genome Sequencing to Identify Causal Genetic Variants Influencing CVD Risk
    David C Glahn; Fiscal Year: 2013
    ..This long- running highly successful project has produced a large number of quantitative trait locus (QTL) localizations of ..
  45. Effect of Satellite Cell Ablation on the Aging Diaphragm
    Esther E Dupont-Versteegden; Fiscal Year: 2013
    ..cells will be ablated at 4 months of age and mice will be subjected to normobaric hypoxia for 4 weeks or running activity for 8 weeks. Analyses will be performed as in Aim 1 and compared to measures obtained from mice in Aim 1...
  46. A Genetic Study of Blood Metabolites and Their Relationship To Diabetes Risk.
    HARALD HEINZ HERBERT GORING; Fiscal Year: 2013
    ..at 2 time points 15-20 years apart) from 1,500 participants in the San Antonio Family Study (SAFS), a long-running study investigating genetic risk for complex diseases and associated quantitative risk factors in Mexican ..
  47. A spinning disk confocal microscope for live-cell imaging
    Anthony Brown; Fiscal Year: 2012
    ..a Masters degree in cell biology and 15 years experience as a laboratory research assistant, including 5 years running a DNA sequencing core facility and 6 years running the Imaging Core Facility in the Center for Molecular ..
  48. Peptidergic Control of Appetitive Ingestive Behaviors
    TIMOTHY JON BARTNESS; Fiscal Year: 2013
    ..that mimics FH in nature, 3) our unique housing system where hamsters earn food pellets to eat and hoard by wheel running, and 4) several approaches: fluorescent in situ hybridization, an unique inhibitor of ghrelin activation (GO-CoA-..
  49. Impacts of universal access to HIV/AIDS care among HIV+ injection drug users
    Evan Wood; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The purpose of this application is to seek renewed funding for a long-running prospective cohort of HIV- infected individuals who use injection drugs (IDU) linked to comprehensive HIV clinical ..
  50. Medications Prescribed in Emergency Departments for Non-Traumatic Dental Conditio
    Christopher Okunseri; Fiscal Year: 2010
    ..study, the 1996-2006 National Hospital Ambulatory Medical Care Survey (NHAMCS), is the longest continuously running nationally representative survey of ED utilization maintained by the National Center for Health Statistics...
  51. Spinning Disk Confocoal Microscope
    Judy Drazba; Fiscal Year: 2010
    ..Dr. Judith Drazba, LRI Imaging Core Director, has over twenty years'confocal experience, fifteen of them running this facility. Three full-time technicians and a Research Associate assist her...
  52. Low Cost Multi-pathogen Laser Diagnostic for HIV and AIDS Co-Infections
    CHRISTOPHER JOHN MYATT; Fiscal Year: 2011
    ..Unfortunately, running such a series of parallel diagnostic tests is cost prohibitive, particularly in low-resource settings...
  53. Rewarding experience and the aging brain
    Erica R Glasper; Fiscal Year: 2010
    ..those of a negative nature, positive experiences involve a rewarding or motivating component-examples including running, eating a high fat diet, and sexual behavior. Each of these experiences activates the HPA axis...
  54. Mechanotransduction Approach to Improve Bone Quality in Osteogenesis Imperfecta
    Charlotte L Phillips; Fiscal Year: 2012
    ..In Aim 3 we will determine if swimming (non-weight bearing) and/or running on a treadmill (weight bearing) exercise regimens will increase muscle contractile generating capacity and ..
  55. Development of a Low Cost, Real-time Biofeedback Gait Retraining System
    SAUNDERS WHITTLESEY; Fiscal Year: 2012
    ..The product will be a commercial system for gait (walking and running) retraining, consisting of a treadmill, streaming 3D Motion Capture and biomechanical analyses, and a video ..
  56. Adolescence, Impulsivity, and Drug Abuse: Sex/Hormones
    Marilyn E Carroll; Fiscal Year: 2012
    ..g., cocaine, heroin) and nondrug (e.g., wheel-running, and sucrose intake) rewards...
  57. Role of Serotonin in Mediating Stress-Induced Infertility
    Judy L Cameron; Fiscal Year: 2013
    ..stress (moving to a new room) and a moderate metabolic stress (a 20% decrease in calorie intake and moderate running for an hour a day, 5 days a week). To date, we have studied monkeys in non-stressed conditions...
  58. UAB Multi-user Fermentation Facility Upgrade
    NORMAN P HIGGINS; Fiscal Year: 2010
    ..Y., L. Zhai, et al. (2007). Nature 449(7165): 1068-72. The lab runs on a break even strategy to recover running costs and salary for the two essential workers. This has worked well since 2001...
  59. The Role of Glucocorticoids in Development and Function of the Endocrine Pancreas
    RONADIP RALPH BANERJEE; Fiscal Year: 2013
    ..experience necessary to achieve his long-term goal of becoming a well-rounded physician-scientist capable of running a research laboratory at a leading academic medical center...
  60. Role of C/EBPbeta in mechanical regulation of MSC potential
    Maya Styner; Fiscal Year: 2013
    ..will be analyzed using substrate stretch to deliver mechanical input in vitro and using wheel based running exercise in mice in vivo...
  61. Acquisition of an Orbitrap XL ETD Mass Spectrometer through Upgrading an LTQ
    Edward Hawrot; Fiscal Year: 2010
    ..As detailed in this proposal, such studies are presently an integral part of a number of existing and long-running NIH-sponsored research projects and with the recent investments in new faculty lines at Brown University in the ..
  62. CRCNS: Multiresolution Modeling of Human Thalamocortical Upstates and Downstates
    Eric Halgren; Fiscal Year: 2013
    ..All of the software for running the models will be shared with other researchers and will be available through the internet in accordance with ..
  63. MUSCULOSKELETAL STIFFNESS AND LOCOMOTION
    CLAIRE FARLEY; Fiscal Year: 2000
    ..However, in some multi-jointed movements, including mammalian running, the elements of the musculoskeletal system are integrated together so that the overall musculoskeletal system ..
  64. Randomized trial of HIV / STD prevention in Zimbabwean youth
    Frances Cowan; Fiscal Year: 2006
    ..is going extremely well however the difficult economic and political climate in Zimbabwe has affected the cost of running the study both because the cost of implementation as originally outlined is more expensive than envisaged and ..
  65. DO 3-D COMPUTER MODELS OF ANATOMY ENHANCE LEARNING?
    James Johnson; Fiscal Year: 2002
    ..Human Project will be used to construct 3-D surface contours using a computer program written by the Co-PI running on a Silicon Graphics Workstation...
  66. Real-time Gait Retraining to Reduce Loading in Runners
    Irene Davis; Fiscal Year: 2009
    ..b>Running is one of the most popular fitness activities that Americans engage in...
  67. PROSPECTIVE STUDY OF HEALTH IN RUNNERS AND WALKERS
    Paul Williams; Fiscal Year: 2002
    ..g., walking) versus vigorous exercise (e.g., running)...
  68. EXERCISE--EFFECTS ON ETOH IMPAIRMENT OF BEHAVIOR IN MICE
    SANDRA MOLLENAUER; Fiscal Year: 1993
    ..Preliminary work has established that five weeks of voluntary wheel running given before EtOH challenge causes significant resistance to EtOH-induced behavioral intoxication, i.e...
  69. BIOMEDICAL RESEARCH SUPPORT
    Peter Henson; Fiscal Year: 1991
    ..Expertise for running extraordinarily high resolution ("giant") 2-D gels exists at Duke University...
  70. COMORBIDITY AND TREATMENT PATHS FOR INDIAN ADOLESCENTS
    Douglas Novins; Fiscal Year: 1999
    ..Depression, suicide, conduct disorder, school dropout, delinquency, and running away have been shown to be related to substance abuse among American Indian adolescents...
  71. Development of an anti-bias caster system
    TODD HARGRODER; Fiscal Year: 2010
    ..Outdoors, sloped terrains are unavoidable-running-slopes (in the direction of travel) are necessary to transitions from one grade to another, and cross-slopes are ..
  72. COMPUTER SYSTEM FOR PATIENT DATA-BASE MANAGEMENT
    Andrew Schachat; Fiscal Year: 1990
    ..An IBM 11/45 running under the UNIX operating systems sufficed for about 10 yrs...
  73. GSH: Protecting Ovarian Follicles from Oxidant Injury
    Ulrike Luderer; Fiscal Year: 2006
    ..Luderer to achieve her goal of running a successful research program resolving the mechanisms of action of ovarian toxicants, translating the findings ..
  74. Foot Prosthesis Using Tensegrity Design Principles
    JEROME RIFKIN; Fiscal Year: 2010
    ..are popular with younger, more-active amputees, because this stiff athletic technology is inherently suited to running and cannot be used by the majority of lower-activity amputees...
  75. Rapid, Universal, Low Cost Automated Genomic DNA Purification from Micro Samples
    WILLIAM MACCONNELL; Fiscal Year: 2007
    ..technology that our company developed for automated plasmid DNA purification with technology we developed for running agarose gels without liquid buffer...
  76. Virtual Realty Systems for Neural Circuit Dynamics
    David W Tank; Fiscal Year: 2010
    ..The technology revolves around the use of head-restrained rodents walking and running on the surface of a levitated sphere...
  77. CNS CCK IN APPETITIVE AND CONSUMMATORY FOOD MOTIVATION
    ELIOT STELLAR; Fiscal Year: 1991
    ..The appetitive measure is the running speed to very small food rewards in a meter-long runway, where postingestional effects are negligible...