motor activity


Summary: The physical activity of a human or an animal as a behavioral phenomenon.

Top Publications

  1. ncbi Tracking of sedentary behaviours of young people: a systematic review
    Stuart J H Biddle
    School of Sport, Exercise and Health Sciences, Loughborough University, UK
    Prev Med 51:345-51. 2010
  2. ncbi The evolving definition of "sedentary"
    Russell R Pate
    Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Exerc Sport Sci Rev 36:173-8. 2008
  3. ncbi Objective measurement of physical activity and sedentary behaviour: review with new data
    J J Reilly
    University Division of Developmental Medicine, 1st Floor Tower Block QMH, Yorkhill Hospitals, Glasgow G3 8SJ, Scotland
    Arch Dis Child 93:614-9. 2008
  4. pmc Amount of time spent in sedentary behaviors in the United States, 2003-2004
    Charles E Matthews
    Institute for Medicine and Public Health, Department of Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232 1738, USA
    Am J Epidemiol 167:875-81. 2008
  5. ncbi Physical activity in the United States measured by accelerometer
    Richard P Troiano
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Med Sci Sports Exerc 40:181-8. 2008
  6. ncbi International physical activity questionnaire: 12-country reliability and validity
    Cora L Craig
    Canadian Fitness and Lifestyle Research Institute, Ottawa, Canada
    Med Sci Sports Exerc 35:1381-95. 2003
  7. ncbi Comparison of accelerometer cut points for predicting activity intensity in youth
    Stewart G Trost
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Med Sci Sports Exerc 43:1360-8. 2011
  8. ncbi 2011 Compendium of Physical Activities: a second update of codes and MET values
    Barbara E Ainsworth
    Exercise and Wellness Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ 85004, USA
    Med Sci Sports Exerc 43:1575-81. 2011
  9. pmc Too much sitting: the population health science of sedentary behavior
    Neville Owen
    The University of Queensland, School of Population Health, Cancer Prevention Research Centre, Brisbane, Australia
    Exerc Sport Sci Rev 38:105-13. 2010
  10. ncbi Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association
    William L Haskell
    Stanford University, USA
    Circulation 116:1081-93. 2007

Detail Information

Publications299 found, 100 shown here

  1. ncbi Tracking of sedentary behaviours of young people: a systematic review
    Stuart J H Biddle
    School of Sport, Exercise and Health Sciences, Loughborough University, UK
    Prev Med 51:345-51. 2010
    ..To review the empirical evidence concerning the strength of tracking of sedentary behaviours from childhood and adolescence...
  2. ncbi The evolving definition of "sedentary"
    Russell R Pate
    Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Exerc Sport Sci Rev 36:173-8. 2008
  3. ncbi Objective measurement of physical activity and sedentary behaviour: review with new data
    J J Reilly
    University Division of Developmental Medicine, 1st Floor Tower Block QMH, Yorkhill Hospitals, Glasgow G3 8SJ, Scotland
    Arch Dis Child 93:614-9. 2008
    ..We also consider unresolved practical issues in paediatric accelerometry by critically reviewing the existing evidence and by providing new evidence...
  4. pmc Amount of time spent in sedentary behaviors in the United States, 2003-2004
    Charles E Matthews
    Institute for Medicine and Public Health, Department of Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232 1738, USA
    Am J Epidemiol 167:875-81. 2008
    ..These data provide the first objective measure of the amount of time spent in sedentary behavior in the US population and indicate that Americans spend the majority of their time in behaviors that expend very little energy...
  5. ncbi Physical activity in the United States measured by accelerometer
    Richard P Troiano
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Med Sci Sports Exerc 40:181-8. 2008
    ..To describe physical activity levels of children (6-11 yr), adolescents (12-19 yr), and adults (20+ yr), using objective data obtained with accelerometers from a representative sample of the U.S. population...
  6. ncbi International physical activity questionnaire: 12-country reliability and validity
    Cora L Craig
    Canadian Fitness and Lifestyle Research Institute, Ottawa, Canada
    Med Sci Sports Exerc 35:1381-95. 2003
    ..The International Physical Activity Questionnaire (IPAQ) was developed as an instrument for cross-national monitoring of physical activity and inactivity...
  7. ncbi Comparison of accelerometer cut points for predicting activity intensity in youth
    Stewart G Trost
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Med Sci Sports Exerc 43:1360-8. 2011
    ..The absence of comparative validity studies has prevented researchers from reaching consensus regarding the application of intensity-related accelerometer cut points for children and adolescents...
  8. ncbi 2011 Compendium of Physical Activities: a second update of codes and MET values
    Barbara E Ainsworth
    Exercise and Wellness Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ 85004, USA
    Med Sci Sports Exerc 43:1575-81. 2011
    ..We provide the second update of the Compendium, called the 2011 Compendium...
  9. pmc Too much sitting: the population health science of sedentary behavior
    Neville Owen
    The University of Queensland, School of Population Health, Cancer Prevention Research Centre, Brisbane, Australia
    Exerc Sport Sci Rev 38:105-13. 2010
    ..Sitting time, TV time, and time sitting in automobiles increase premature mortality risk. Further evidence from prospective studies, intervention trials, and population-based behavioral studies is required...
  10. ncbi Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association
    William L Haskell
    Stanford University, USA
    Circulation 116:1081-93. 2007
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  11. ncbi Evidence based physical activity for school-age youth
    William B Strong
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
    J Pediatr 146:732-7. 2005
    ..To review the effects of physical activity on health and behavior outcomes and develop evidence-based recommendations for physical activity in youth...
  12. ncbi Calibration of two objective measures of physical activity for children
    Kelly R Evenson
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill 27514 USA
    J Sports Sci 26:1557-65. 2008
    ..This calibration study, using indirect calorimetry, suggests that the two accelerometers can be used to distinguish differing levels of physical activity intensity as well as inactivity among children 5 to 8 years of age...
  13. pmc PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
    Seung Hee Yoo
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 101:5339-46. 2004
    ..These results demonstrate that peripheral tissues express self-sustained, rather than damped, circadian oscillations and suggest the existence of organ-specific synchronizers of circadian rhythms at the cell and tissue level...
  14. ncbi A sensitive and reliable locomotor rating scale for open field testing in rats
    D M Basso
    Department of Cell Biology, Neurobiology and Anatomy, Ohio State University, Columbus, USA
    J Neurotrauma 12:1-21. 1995
    ..The BBB Locomotor Rating Scale offers investigators a more discriminating measure of behavioral outcome to evaluate treatments after spinal cord injury...
  15. ncbi Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease
    Marc T Hamilton
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Diabetes 56:2655-67. 2007
  16. ncbi Adults' sedentary behavior determinants and interventions
    Neville Owen
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Am J Prev Med 41:189-96. 2011
    ..It would be informative for the field to have evidence on the outcomes of "natural experiments," such as the introduction of nonseated working options in occupational environments or new transportation infrastructure in communities...
  17. ncbi Physiological and health implications of a sedentary lifestyle
    Mark Stephen Tremblay
    Healthy Active Living and Obesity Research Group, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON K1H 8L1 Canada
    Appl Physiol Nutr Metab 35:725-40. 2010
    ..Evidence relating to associations of sedentary behaviours with major health outcomes and the population prevalence and correlates of sedentary behaviours are reviewed. Recommendations for future research are proposed...
  18. ncbi Global physical activity questionnaire (GPAQ): nine country reliability and validity study
    Fiona C Bull
    School of Sport and Exercise Sciences, University of Loughborough, Perth, Australia
    J Phys Act Health 6:790-804. 2009
    ..Instruments to assess physical activity are needed for (inter)national surveillance systems and comparison...
  19. ncbi Depression: a new animal model sensitive to antidepressant treatments
    R D Porsolt
    Nature 266:730-2. 1977
  20. ncbi Neighborhood SES and walkability are related to physical activity behavior in Belgian adults
    Delfien Van Dyck
    Fund for Scientific Research Flanders FWO, Belgium
    Prev Med 50:S74-9. 2010
    ..To investigate whether neighborhood walkability (higher residential density, land use mix, street connectivity) is positively associated with physical activity in Belgian adults and whether this association is moderated by neighborhood SES...
  21. pmc Mop3 is an essential component of the master circadian pacemaker in mammals
    M K Bunger
    The McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, WI 53706, USA
    Cell 103:1009-17. 2000
    ..These results provide genetic evidence that MOP3 is the bona fide heterodimeric partner of mCLOCK. Furthermore, these data demonstrate that MOP3 is a nonredundant and essential component of the circadian pacemaker in mammals...
  22. ncbi Breaks in sedentary time: beneficial associations with metabolic risk
    Genevieve N Healy
    Cancer Prevention Research Centre, School of Population Health, The University of Queensland, Brisbane, Australia
    Diabetes Care 31:661-6. 2008
    ..In addition to the effects of total sedentary time, the manner in which it is accumulated may also be important. We examined the association of breaks in objectively measured sedentary time with biological markers of metabolic risk...
  23. ncbi Canadian Physical Activity Guidelines for the Early Years (aged 0-4 years)
    Mark S Tremblay
    University of Ottawa, Ottawa, ON, Canada
    Appl Physiol Nutr Metab 37:345-69. 2012
    ..More daily physical activity provides greater benefits...
  24. ncbi Understanding physical activity environmental correlates: increased specificity for ecological models
    Billie Giles-Corti
    School of Population Health, The University of Western Australia, Perth, Australia
    Exerc Sport Sci Rev 33:175-81. 2005
    ..This selective review examines whether the predictive capacity of these models could be improved if behavior-specific measures of the environment were used to predict context-specific behaviors...
  25. pmc Obesity and metabolic syndrome in circadian Clock mutant mice
    Fred W Turek
    Department of Neurology, Northwestern University, Evanston, IL 60208, USA
    Science 308:1043-5. 2005
    ..These results suggest that the circadian clock gene network plays an important role in mammalian energy balance...
  26. ncbi Physical activity in patients with COPD
    H Watz
    Pulmonary Research Institute Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, Grosshansdorf, Germany
    Eur Respir J 33:262-72. 2009
    ..Clinical characteristics of patients with chronic obstructive pulmonary disease only incompletely reflect their physical activity...
  27. ncbi The International Physical Activity Questionnaire (IPAQ): a study of concurrent and construct validity
    Maria Hagstromer
    Unit for Preventive Nutrition Novum, Department of Biosciences, Karolinska Institutet, S 141 57 Huddinge, Sweden
    Public Health Nutr 9:755-62. 2006
    ..The short version of the IPAQ has been tested extensively and is now used in many international studies. The present study aimed to explore the validity characteristics of the long-version IPAQ...
  28. ncbi Characteristics of physical activities in daily life in chronic obstructive pulmonary disease
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 171:972-7. 2005
    ..28 < r < 0.64, p < 0.05). Patients with chronic obstructive pulmonary disease are markedly inactive in daily life. Functional exercise capacity is the strongest correlate of physical activities in daily life...
  29. pmc Leisure time spent sitting in relation to total mortality in a prospective cohort of US adults
    Alpa V Patel
    Epidemiology Research Program, American Cancer Society, 250 Williams Street NW, Atlanta, GA 30303, USA
    Am J Epidemiol 172:419-29. 2010
    ..The time spent sitting was independently associated with total mortality, regardless of physical activity level. Public health messages should include both being physically active and reducing time spent sitting...
  30. ncbi Neighborhood environment and physical activity among youth a review
    Ding Ding
    Graduate School of Public Health, San Diego State University, California, USA
    Am J Prev Med 41:442-55. 2011
    ..An updated review of literature is needed to summarize the current evidence base, and to inform policies and environmental interventions to promote active lifestyles among young people...
  31. pmc Use of global positioning systems to study physical activity and the environment: a systematic review
    Patricia J Krenn
    Institute of Sport Science, University of Graz, Austria
    Am J Prev Med 41:508-15. 2011
    ..The aim of this systematic review was to determine the capability of GPS to collect high-quality data on the location of activities in research on the relationship between physical activity and the environment...
  32. pmc Measuring the built environment for physical activity: state of the science
    Ross C Brownson
    Prevention Research Center in St Louis, George Warren Brown School of Social Work, Washington University in St Louis, St Louis, Missouri 63110, USA
    Am J Prev Med 36:S99-123.e12. 2009
    ..In particular, further research is needed to improve the technical quality of measures, understand the relevance to various population groups, and understand the utility of measures for science and public health...
  33. ncbi Physical activity of Canadian children and youth: accelerometer results from the 2007 to 2009 Canadian Health Measures Survey
    Rachel C Colley
    Children s Hospital of Eastern Ontario Research Institute and the Health Analysis Division at Statistics Canada
    Health Rep 22:15-23. 2011
    ..Physical activity is an important determinant of health and fitness. This study provides contemporary estimates of the physical activity levels of Canadians aged 6 to 19 years...
  34. ncbi Reliability and validity of the combined heart rate and movement sensor Actiheart
    S Brage
    MRC Epidemiology Unit, Institute of Public Health, University of Cambridge, CB1 9NL, UK
    Eur J Clin Nutr 59:561-70. 2005
    ..The Actiheart, a combined heart rate (HR) and movement sensor, is designed to assess physical activity in populations...
  35. ncbi Assessment of physical activity - a review of methodologies with reference to epidemiological research: a report of the exercise physiology section of the European Association of Cardiovascular Prevention and Rehabilitation
    Janet M Warren
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Eur J Cardiovasc Prev Rehabil 17:127-39. 2010
    ..A framework is presented to guide researchers on the selection of the most suitable tool for use in a specific study...
  36. ncbi Physical activity levels and patterns of 9- and 15-yr-old European children
    Chris J Riddoch
    Department of Exercise and Health Sciences, University of Bristol, Bristol, UK
    Med Sci Sports Exerc 36:86-92. 2004
    ..Very limited physical activity data exist that have been collected from representative samples of children and even fewer data collected where physical activity has been measured using objective methods...
  37. ncbi How many steps/day are enough? Preliminary pedometer indices for public health
    Catrine Tudor-Locke
    Department of Exercise and Wellness, Arizona State University, Mesa, Arizona 85212, USA
    Sports Med 34:1-8. 2004
    ..or=10000 steps/day indicates the point that should be used to classify individuals as 'active'. Individuals who take >12500 steps/day are likely to be classified as 'highly active'...
  38. pmc Sedentary activity associated with metabolic syndrome independent of physical activity
    Andrea Bankoski
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Diabetes Care 34:497-503. 2011
    ..This study examined the association between objectively measured sedentary activity and metabolic syndrome among older adults...
  39. ncbi Optimal feedback control as a theory of motor coordination
    Emanuel Todorov
    Department of Cognitive Science, University of California, San Diego, 9500 Gilman Dr, La Jolla, California 92093 0515, USA
    Nat Neurosci 5:1226-35. 2002
    ..We present experimental results from a range of motor tasks to support this theory...
  40. pmc Dose response between physical activity and risk of coronary heart disease: a meta-analysis
    Jacob Sattelmair
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Circulation 124:789-95. 2011
    ..Instead, previous reviews have used qualitative estimates such as low, moderate, and high physical activity...
  41. ncbi The built environment and obesity: a systematic review of the epidemiologic evidence
    Jing Feng
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Health Place 16:175-90. 2010
    ..There was very little between-study similarity in methods in both types of approaches, which prevented estimation of pooled effects. The great heterogeneity across studies limits what can be learned from this body of evidence...
  42. pmc A review of accelerometry-based wearable motion detectors for physical activity monitoring
    Che Chang Yang
    Department of Mechanical Engineering, Yuan Ze University 135, Yuan Tung Rd, Chung Li, 32003, Taiwan
    Sensors (Basel) 10:7772-88. 2010
    ..Finally this paper reviews and compares existing commercial products to provide a comprehensive outlook of current development status and possible emerging technologies...
  43. ncbi Tracking of physical activity from childhood to adulthood: a review
    Risto Telama
    LIKES Research Institute, Jyvaskyla, Finland
    Obes Facts 2:187-95. 2009
    ..The results of the tracking studies support the idea that the enhancement of physical activity in children and adolescents is of great importance for the promotion of public health...
  44. pmc Combined impact of health behaviours and mortality in men and women: the EPIC-Norfolk prospective population study
    Kay Tee Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    PLoS Med 5:e12. 2008
    ..We aimed to quantify the potential combined impact of four health behaviours on mortality in men and women living in the general community...
  45. ncbi Correlates of adults' participation in physical activity: review and update
    Stewart G Trost
    School of Human Movement Studies, University of Queensland, Brisbane QLD 4072, Australia
    Med Sci Sports Exerc 34:1996-2001. 2002
    ..To review and update the evidence relating to the personal, social, and environmental factors associated with physical activity (PA) in adults...
  46. pmc Best practices for using physical activity monitors in population-based research
    Charles E Matthews
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 7344, USA
    Med Sci Sports Exerc 44:S68-76. 2012
    ..A checklist and flowchart are provided so that investigators have more guidance when reporting key elements of monitor use in their studies...
  47. ncbi The tail suspension test: a new method for screening antidepressants in mice
    L Steru
    Psychopharmacology (Berl) 85:367-70. 1985
  48. ncbi Overweight in children and adolescents: pathophysiology, consequences, prevention, and treatment
    Stephen R Daniels
    Circulation 111:1999-2012. 2005
    ..In addition, treatment approaches are presented, including behavioral, pharmacological, and surgical treatment. Childhood and adolescent overweight is one of the most important current public health concerns...
  49. ncbi Entrainment of the circadian clock in the liver by feeding
    K A Stokkan
    National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, P O Box 400328, Charlottesville, VA 22904 4328, USA
    Science 291:490-3. 2001
    ..They also raise the possibility that peripheral circadian oscillators like those in the liver may be coupled to the SCN primarily through rhythmic behavior, such as feeding...
  50. ncbi ALE meta-analysis of action observation and imitation in the human brain
    Svenja Caspers
    Institute of Neuroscience and Medicine INM 2, Research Centre Julich, Julich, Germany
    Neuroimage 50:1148-67. 2010
    ..e., caudal BA 44. The present meta-analysis thus summarizes and amends previous descriptions of the human brain networks related to action observation and imitation...
  51. ncbi C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway
    E R Sawin
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 26:619-31. 2000
    ..The basal and enhanced slowing responses are distinct and separable neuromodulatory components of a genetically tractable paradigm of behavioral plasticity...
  52. pmc Neighborhood built environment and income: examining multiple health outcomes
    James F Sallis
    Department of Psychology, San Diego State University, San Diego, CA 92103, USA
    Soc Sci Med 68:1285-93. 2009
    ..Lower- and higher-income groups benefited similarly from living in high-walkability neighborhoods. Adults in higher-income neighborhoods had lower BMI and higher physical QoL...
  53. ncbi Branched equation modeling of simultaneous accelerometry and heart rate monitoring improves estimate of directly measured physical activity energy expenditure
    Søren Brage
    Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense University, DK 5230 Odense, Denmark
    J Appl Physiol (1985) 96:343-51. 2004
    ..7%). In conclusion, combining HR and CSA by branched modeling improves estimates of PAEE. IC may be less crucial with this modeling technique...
  54. ncbi Physical activity change during adolescence: a systematic review and a pooled analysis
    Samuel C Dumith
    Post Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
    Int J Epidemiol 40:685-98. 2011
    ..Therefore, the purpose was to systematically review the international literature regarding PA change during adolescence, and to quantify that change according to a series of study variables, exploring gender-and-age differences...
  55. ncbi The ABC of Physical Activity for Health: a consensus statement from the British Association of Sport and Exercise Sciences
    Gary O'Donovan
    School of Sport and Health Sciences, University of Exeter, Exeter, UK
    J Sports Sci 28:573-91. 2010
    ..Children and young people aged 5-16 years should accumulate at least 60 min of moderate-to-vigorous-intensity aerobic activity per day, including vigorous-intensity aerobic activities that improve bone density and muscle strength...
  56. ncbi Global physical activity levels: surveillance progress, pitfalls, and prospects
    Pedro C Hallal
    Universidade Federal de Pelotas, Brazil
    Lancet 380:247-57. 2012
    ..Continued improvement in monitoring of physical activity would help to guide development of policies and programmes to increase activity levels and to reduce the burden of non-communicable diseases...
  57. ncbi Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders
    E Masliah
    Department of Neurosciences, Department of Pathology, University of California San Diego, La Jolla, CA 92093 0624, USA
    Science 287:1265-9. 2000
    ..These results suggest that accumulation of wild-type alpha-synuclein may play a causal role in Parkinson's disease and related conditions...
  58. ncbi Targeting sedentary time or moderate- and vigorous-intensity activity: independent relations with adiposity in a population-based sample of 10-y-old British children
    Rebekah M Steele
    Medical Research Council Epidemiology Unit, Cambridge, United Kingdom
    Am J Clin Nutr 90:1185-92. 2009
    ..It is unclear whether subcomponents of physical activity (PA) are associated with adiposity independent of time spent while sedentary...
  59. ncbi Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
    D Michele Basso
    Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurotrauma 23:635-59. 2006
    ..05). The differing behavioral response to SCI suggests inherent genetic factors significantly impact locomotor recovery and must be considered in studies with inbred or genetically engineered mouse strains...
  60. ncbi Potential environmental determinants of physical activity in adults: a systematic review
    W Wendel-Vos
    Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Obes Rev 8:425-40. 2007
    ..However, most studies used cross-sectional designs and non-validated measures of environments and/or behaviour. Therefore, no strong conclusions can be drawn and more research of better quality is clearly needed...
  61. pmc Internet-based physical activity interventions: a systematic review of the literature
    Marleen H van den Berg
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    J Med Internet Res 9:e26. 2007
    ..The Internet has been brought forward as an effective tool to change physical activity behavior. However, little is known about the evidence regarding such Internet-based interventions...
  62. ncbi Telephone-delivered interventions for physical activity and dietary behavior change: an updated systematic review
    Ana D Goode
    Cancer Prevention Research Centre, School of Population Health, The University of Queensland, Brisbane, Queensland, Australia
    Am J Prev Med 42:81-8. 2012
    ..The purpose of this systematic review is to update the evidence for their potential to inform translation, including effectiveness in promoting maintenance, reporting on implementation, and costs...
  63. ncbi Reactive astrocytes protect tissue and preserve function after spinal cord injury
    Jill R Faulkner
    Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
    J Neurosci 24:2143-55. 2004
  64. ncbi Parietal lobe: from action organization to intention understanding
    Leonardo Fogassi
    Dipartimento di Psicologia, Universita di Parma, Borgo Carissimi 10, 43100 Parma, Italy
    Science 308:662-7. 2005
    ..Thus, these neurons not only code the observed motor act but also allow the observer to understand the agent's intentions...
  65. ncbi Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical
    Paul D Thompson
    Circulation 107:3109-16. 2003
  66. ncbi Genetics of mouse behavior: interactions with laboratory environment
    J C Crabbe
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97201, USA
    Science 284:1670-2. 1999
    ..For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory...
  67. pmc Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation
    Jason Rihel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 327:348-51. 2010
    ..These results demonstrate the power of high-throughput behavioral profiling in zebrafish to discover and characterize psychotropic drugs and to dissect the pharmacology of complex behaviors...
  68. ncbi Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
    G T van der Horst
    MGC, Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Nature 398:627-30. 1999
    ..This suggests that, in addition to a possible photoreceptor and antagonistic clock-adjusting function, both proteins are essential for the maintenance of circadian rhythmicity...
  69. ncbi Levels and patterns of objectively assessed physical activity--a comparison between Sweden and the United States
    Maria Hagstromer
    Department of Neurobiology, Karolinska Institutet, Huddinge, Sweden
    Am J Epidemiol 171:1055-64. 2010
    ..These results provide a framework for international comparisons of physical activity levels and patterns, and they represent strong evidence for the importance of investment in objective measurement of physical activity...
  70. ncbi Seeing or doing? Influence of visual and motor familiarity in action observation
    Beatriz Calvo-Merino
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, 17 Queen Square, WC1N 3AR London, United Kingdom
    Curr Biol 16:1905-10. 2006
    ..We understand actions not only by visual recognition, but also motorically. In addition, we confirm that the cerebellum is part of the action observation network...
  71. ncbi Associations of TV viewing and physical activity with the metabolic syndrome in Australian adults
    D W Dunstan
    International Diabetes Institute, Melbourne, Victoria, Australia
    Diabetologia 48:2254-61. 2005
    ..We analysed a sample of Australian adults to determine the strength of associations of TV viewing and participation in physical activity with the metabolic syndrome...
  72. ncbi Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo
    Edor Kabashi
    Centre of Excellence in Neuromics, Department of Medicine, Universite de Montre al, Montreal, Quebec, Canada
    Hum Mol Genet 19:671-83. 2010
  73. ncbi Understanding participation in sport and physical activity among children and adults: a review of qualitative studies
    Steven Allender
    Public Health, University of Oxford, Rosemary Rue Building, Old Road Campus, Oxford, UK
    Health Educ Res 21:826-35. 2006
    ..Challenges to identity such as having to show others an unfit body, lacking confidence and competence in core skills or appearing overly masculine were barriers to participation...
  74. pmc TV viewing and physical activity are independently associated with metabolic risk in children: the European Youth Heart Study
    Ulf Ekelund
    Epidemiology Unit, Medical Research Council, Cambridge, United Kingdom
    PLoS Med 3:e488. 2006
    ..TV viewing has been linked to metabolic-risk factors in youth. However, it is unclear whether this association is independent of physical activity (PA) and obesity...
  75. ncbi Physical activity questionnaires for adults: a systematic review of measurement properties
    Mireille N M van Poppel
    Department of Public and Occupational Health, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Sports Med 40:565-600. 2010
    ..We searched MEDLINE, EMBASE and SportDiscus, using 'exercise', 'physical activity', 'motor activity' and 'questionnaire' as keywords...
  76. ncbi Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association
    Miriam E Nelson
    Tufts University
    Circulation 116:1094-105. 2007
    ..To issue a recommendation on the types and amounts of physical activity needed to improve and maintain health in older adults...
  77. pmc Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
    Tsuyoshi Miyakawa
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory and RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:8987-92. 2003
    ..Collectively, the abnormalities of CN mutant mice are strikingly similar to those described for schizophrenia. We propose that alterations affecting CN signaling could comprise a contributing factor in schizophrenia pathogenesis...
  78. ncbi The effect of season and weather on physical activity: a systematic review
    P Tucker
    Faculty of Health Sciences, University of Western Ontario, Ontario, Canada
    Public Health 121:909-22. 2007
    ..This study reviewed previous studies to explore the effect of season, and consequently weather, on levels of physical activity...
  79. ncbi Functional mapping of human sensorimotor cortex with electrocorticographic spectral analysis. II. Event-related synchronization in the gamma band
    N E Crone
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Brain 121:2301-15. 1998
    ..In addition, gamma ERS may provide complementary information about cortical neurophysiology that is useful for mapping brain function in humans...
  80. pmc Contribution of transcranial magnetic stimulation to the understanding of cortical mechanisms involved in motor control
    Janine Reis
    Human Cortical Physiology Section, National Institute of Health, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Bldg 10, Rm 5 N226, Bethesda, MD 20892, USA
    J Physiol 586:325-51. 2008
    ..Finally, areas of uncertainty and limitations in the interpretation of TMS studies are discussed in some detail...
  81. ncbi Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial
    Steven L Wolf
    Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    JAMA 296:2095-104. 2006
  82. ncbi Objectively measured time spent sedentary is associated with insulin resistance independent of overall and central body fat in 9- to 10-year-old Portuguese children
    Luis B Sardinha
    Faculty of Human Movement, Technical University of Lisbon, Lisbon, Portugal
    Diabetes Care 31:569-75. 2008
    ..We examined the independent relationships between objectively measured physical activity and insulin resistance in Portuguese children...
  83. ncbi Grip strength, postural control, and functional leg power in a representative cohort of British men and women: associations with physical activity, health status, and socioeconomic conditions
    Diana Kuh
    MRC National Survey of Health and Development, Department of Epidemiology and Public Health, Royal Free and University College Medical School, 1 19 Torrington Place, London, United Kingdom, WC1E 6BT
    J Gerontol A Biol Sci Med Sci 60:224-31. 2005
  84. ncbi Accelerometer-determined physical activity in adults and older people
    Bjørge Herman Hansen
    Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway
    Med Sci Sports Exerc 44:266-72. 2012
    ..We conducted a cross-sectional population-based multicenter study to describe the levels of PA and sedentary activity and to determine adherence to current national PA recommendations in Norwegian adults and older people...
  85. pmc Objectively measured physical activity and fat mass in a large cohort of children
    Andy R Ness
    Department of Oral and Dental Science, University of Bristol, United Kingdom
    PLoS Med 4:e97. 2007
    ..Previous studies have been unable to characterise the association between physical activity and obesity, possibly because most relied on inaccurate measures of physical activity and obesity...
  86. ncbi Trend and prevalence estimates based on the 2008 Physical Activity Guidelines for Americans
    Susan A Carlson
    National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, Georgia 30341, USA
    Am J Prev Med 39:305-13. 2010
    ..In addition to aerobic activity, the 2008 Guidelines recommend that adults participate in muscle-strengthening activities on 2 or more days/week...
  87. pmc Aging in neighborhoods differing in walkability and income: associations with physical activity and obesity in older adults
    Abby C King
    Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Soc Sci Med 73:1525-33. 2011
    ..The results add to the small literature aimed at understanding how neighborhood design may influence physical activity and related aspects of health linked with day-to-day function and independence as people age...
  88. pmc Using internet and mobile phone technology to deliver an automated physical activity program: randomized controlled trial
    Robert Hurling
    Unilever Corporate Research, Colworth, Bedford, United Kingdom
    J Med Internet Res 9:e7. 2007
  89. ncbi American College of Sports Medicine Position Stand: physical activity and bone health
    Wendy M Kohrt
    Med Sci Sports Exerc 36:1985-96. 2004
  90. pmc Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish
    Rupert J Egan
    Stress Physiology and Research Center SPaRC, Department of Physiology and Biophysics, Georgetown University Medical School, 3900 Reservoir Road, Washington, DC 20057, USA
    Behav Brain Res 205:38-44. 2009
    ..Collectively, our results confirm zebrafish as a valid, reliable, and high-throughput model of stress and affective disorders...
  91. ncbi Exercise physiology versus inactivity physiology: an essential concept for understanding lipoprotein lipase regulation
    Marc T Hamilton
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, MO, USA
    Exerc Sport Sci Rev 32:161-6. 2004
    ..The most powerful process known to regulate lipoprotein lipase protein and activity in muscle capillaries may be initiated by inhibitory signals during physical inactivity, independent of changes in lipoprotein lipase messenger RNA...
  92. ncbi Effect of lifestyle intervention on dietary habits, physical activity, and gestational weight gain in obese pregnant women: a randomized controlled trial
    Isabelle Guelinckx
    Department of Nutrition Public Health Medicine, LFoRCe, Catholic University Leuven, Leuven, Belgium
    Am J Clin Nutr 91:373-80. 2010
    ..Maternal obesity and excessive gestational weight gain (GWG) are major short- and long-term risk factors for maternal and fetal complications...
  93. ncbi A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field
    E Choleris
    Room 9222D, Department of Psychology, Social Science Center, University of Western Ontario, London, Ontario, Canada N6A 5C2
    Neurosci Biobehav Rev 25:235-60. 2001
    ..e. pulsed magnetic field) on anxiety-like behaviors, but also permits the examination of non-specific effects, in particular those on general activity...
  94. ncbi Revisiting Lévy flight search patterns of wandering albatrosses, bumblebees and deer
    Andrew M Edwards
    British Antarctic Survey, High Cross, Madingley Road, Cambridge CB3 0ET, UK
    Nature 449:1044-8. 2007
    ..Our results question the strength of the empirical evidence for biological Lévy flights...
  95. pmc Stimulus onset quenches neural variability: a widespread cortical phenomenon
    Mark M Churchland
    Department of Electrical Engineering, Stanford University School of Medicine, Stanford University, Stanford, California, USA
    Nat Neurosci 13:369-78. 2010
    ..This widespread variability decline suggests a rather general property of cortex, that its state is stabilized by an input...
  96. pmc Physical activity and the association of common FTO gene variants with body mass index and obesity
    Evadnie Rampersaud
    Department of Medicine, University of Maryland, Baltimore, USA
    Arch Intern Med 168:1791-7. 2008
    ..The role of lifestyle factors (such as physical activity) in those with an underlying FTO genetic predisposition is unknown...
  97. ncbi The prevalence and clustering of four major lifestyle risk factors in an English adult population
    Wouter Poortinga
    Cardiff University, UK
    Prev Med 44:124-8. 2007
  98. ncbi Physical activity questionnaires for youth: a systematic review of measurement properties
    Mai J M Chinapaw
    Department of Public and Occupational Health, The EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Sports Med 40:539-63. 2010
    ..Considerably more high-quality research is required to examine the validity and reliability of promising PA questionnaires for youth...
  99. ncbi Methodological considerations in using accelerometers to assess habitual physical activity in children aged 0-5 years
    Dylan P Cliff
    Child Obesity Research Centre, University of Wollongong, Australia
    J Sci Med Sport 12:557-67. 2009
    ..Recommendations for further research are outlined, based on the above findings, which, if undertaken, will enhance the accuracy of accelerometer-based assessments of habitual physical activity in young children...
  100. pmc Factors related to objectively measured physical activity in preschool children
    Karin A Pfeiffer
    Department of Kinesiology, Michigan State University, East Lansing, MI 48824, USA
    Pediatr Exerc Sci 21:196-208. 2009
    ..The NSA model included the latter two variables, explaining 35% of the variance. Demographic factors were correlates of PA; parent perceptions of children's...
  101. pmc Physical activity, obesity and cardiometabolic risk factors in 9- to 10-year-old UK children of white European, South Asian and black African-Caribbean origin: the Child Heart And health Study in England (CHASE)
    C G Owen
    Division of Community Health Sciences, St George s University of London, Cranmer Terrace, London SW17 ORE, UK
    Diabetologia 53:1620-30. 2010
    ..We examined these associations in UK children of South Asian, black African-Caribbean and white European origin...

Research Grants75

  1. Validation of Measures of Restless Legs Syndrome for Elders with Memory Disorders
    Kathy Richards; Fiscal Year: 2009
    ..b>Motor activity such as leg movement, signs of leg discomfort such as rubbing the legs, and iron deficiency may indicate RLS...
  2. Subtype Specific Agonists for D1-D5 Dopamine Receptors
    William Goddard; Fiscal Year: 2007
    ..applicant): The dopaminergic system plays an important role in the control of a variety of functions including motor activity, cognition, emotion, positive reinforcement, pleasure and reward, food intake, and endocrine regulation...
  3. Developmental Psychopharmacology of Antipsychotics
    JENNY WILEY; Fiscal Year: 2007
    ..of selected antipsychotics; subsequently, they will be evaluated in behavioral procedures designed to measure motor activity (locomotion and catalepsy)...
  4. Ventral Mesopontine Junction and Motor Activity
    Yuan Yang Lai; Fiscal Year: 2006
    ..We hypothesize that VMPJ projections to the caudal brainstem regulate motor activity in SWS and REM sleep...
    JAY WEISS; Fiscal Year: 2001
    ..and therapy of depression, basic research implicates dopamine (DA) in depression-related responses (motor activity changes, hedonic responses) much more so than NE...
  6. Respiratory and autonomic plasticity following intermittent hypoxia
    JASON HAROLD MATEIKA; Fiscal Year: 2012
    ..This phenomenon is characterized by a gradual increase in respiratory motor activity and SNSA during successive periods of normoxia that separate hypoxic episodes and by activity that persists ..
  7. Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null Mic
    Yuqing Li; Fiscal Year: 2010
    ..These experiments will reveal whether mutant Btbd9 mice show any circadian variation of motor activity. 3...
  8. Low level exposure to PBDEs: testing the hormetic and epigenetic hypotheses
    Lucio G Costa; Fiscal Year: 2013
    ..prenatal and/or postnatal periods causes long-lasting behavioral abnormalities, particularly in the domains of motor activity and cognition...
  9. Molecular control of differential peptide transmitter exocytosis.
    COREY B SMITH; Fiscal Year: 2013
    ..event, subsequent recruitment of a multimeric pore-expansion complex, and requirement for myosin motor activity in the regulation of fusion pore expansion...
  10. Testing Compounds that Increase SMN levels for Efficacy in Mouse Models of SMA
    Elliot J Androphy; Fiscal Year: 2010
    ..this proposal is identification of pharmacologically suitable compounds that increase SMN levels and restore motor activity in SMA model mice that can be advanced to human trials...
  11. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2012
    ..Basal ganglia DA plays a pivotal role in regulating multiple behaviors including mood, motivation/reward, motor activity, sleep and cognition...
  12. Developmental defects in serotonin neurons and the response to O2 and CO2
    George B Richerson; Fiscal Year: 2011
    ..We will expose adult and neonatal mice to hypercapnia and hypoxia, and measure ventilation, heart rate, motor activity and EEG. We will also examine the effect on wild-type and mutant mice of prenatal exposure to cigarette smoke...
  13. CB1 Receptor Regulation by Cannabinoid Receptor Interacting Protein CRIP1a
    DANA E contact SELLEY; Fiscal Year: 2010
    ..This endocannabinoid system plays important roles in regulating motor activity and coordination, short-term memory, pain perception, metabolic homeostasis and drug reward and craving...
  14. Cooperative lead development program for treatment of spinal muscular atrophy
    Elliot J Androphy; Fiscal Year: 2012 identification of pharmacologically suitable drug-like compounds that increase SMN levels and restore motor activity in SMA model mice that can be rapidly advanced to human trials...
  15. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013 be important for a range of functions, including attention, early sensory processing, short term memory, motor activity. Mental illnesses, notably schizophrenia, are associated with pathologies in this rhythm, and many people are ..
  16. Inflammatory Cytokine regulation of POMC and Orexin neurons in cachexia.
    AARON GROSSBERG; Fiscal Year: 2012
    ..inflammation, activity of orexin neurons will be evauated histochemically and correlated to measurements of motor activity, food intake, and body composition...
  17. Regulation of striatal cannabinoid CB1 receptors by DARPP32 and deltaFosB mediate
    Matthew F Lazenka; Fiscal Year: 2012
    ..RELEVANCE: Marijuana and cannabinoid drugs modulate the function of brain regions that control motivation and motor activity. The proposed studies will determine the effects of repeated cannabinoid administration on biochemical ..
  18. Cytokine Effects on Amphetamine-Induced Dopamine Release using PET Neuroimaging
    Jennifer C Felger; Fiscal Year: 2011
    ..Basal ganglia DA plays a pivotal role in regulating behaviors including mood, motor activity, motivation and reward, and mounting evidence indicates that the DA system may be targeted by innate immune ..
  19. Alteration of circadian rhythm and sleep by HIV protein Tat
    Jian M Ding; Fiscal Year: 2012
    ..and sleep pattern in the Tat-expressing mouse is comparable to clinical findings, characterized with reduced motor activity and impaired synchronization to the environmental light dark cycle...
  20. Gastrointestinal Smooth Muscle in Health &Disease
    Joseph H Szurszewski; Fiscal Year: 2012 experimental animal models and in the human and the role of H2S in ganglion neurons that regulate colonic motor activity. We anticipate our studies will provide mechanistic information relevant not only to the gastrointestinal ..
  21. Molecular roles in active and passive mechanics in cochlear hair bundles
    ANTHONY WEI PENG; Fiscal Year: 2013
    ..will be performed using these novel MEMS devices to characterize mechanics of the hair bundle when modifying motor activity. From these experiments, the role of molecular motors as well as the upper tip-link region in cochlear hair ..
  22. Pathogenesis of Sleep Disordered Breathing in Spinal Cord Injury Patients
    ABDUL SANKRI-TARBICHI; Fiscal Year: 2013
    ..Specific Aim (3): To determine the stimulatory effect of systemic serotonin receptors agonists on ventilatory motor activity in SCI patients during sleep...
  23. Endocannabinoid modulation of pain-depressed behavior
    LAURA J SIMSELLEY; Fiscal Year: 2013 indicated by absences from work or school, lack of interest in customary activities, overall decreases in motor activity, and is most often associated with clinical depression...
  24. Regulation of outer hair cell electromotility and noise-induced hearing loss
    Gregory I Frolenkov; Fiscal Year: 2013
    ..Our preliminary data show that direct activation of TRPA1 channels by specific agonists inhibits the motor activity of prestin in the outer hair cells...
  25. The Antidepressant Action of Ketamine:Brain Chemistry
    MATE ISTVAN MILAK; Fiscal Year: 2013
    ..increase in synaptic signaling proteins, the number of new spine dendrites, synaptogenesis, and increased motor activity in animal models of depression ensues...
    NEIL ALAN SHNEIDER; Fiscal Year: 2013
    ..differentiation and survival and on the functional development of spinal motor circuits required for normal motor activity. By high-throughput RNA sequencing (RNA Seq), we will explore the normal role of FUS in the regulation of gene ..
    Don W Cleveland; Fiscal Year: 2013
    ..We will now determine how this switch modulates CENP-E motor activity and the role of PP1-bound CENP-E in reactivating capture of spindle microtubules by kinetochores of initially ..
  28. CaMKII, endocannabinoids, synaptic plasticity and motor function
    Roger J Colbran; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The striatum plays a key role in motor activity/coordination and goal-directed, habitual learning...
  29. Viral Encephalitis, Chemokines and Sleep
    LARRY D contact SANFORD; Fiscal Year: 2010 a model for examining the role of chemokines and cytokines in modulating sleep, temperature and motor activity in response to infection...
  30. Microtubule Complexes Involved in Intracelluar Transport
    Ronald D Vale; Fiscal Year: 2013
    ..We will study activators of the dynein motor protein, in particular testing the notion that they affect dynein motor activity. We have also identified a new protein that may regulate dynein at kinetochores, and we will pursue further ..
  31. Sleep, proprioception, and forebrain activity in infant mutant mice
    MARK SAMUEL BLUMBERG; Fiscal Year: 2013
    ..Accordingly, it has been suggested that spontaneous, sleep-related motor activity contributes to the development of neural circuits within and between neocortex and hippocampus, just as ..
  32. L-DOPA-induced dyskinesias and dysregulation of striatopallidal neurons
    STEVEN MICHAEL GRAVES; Fiscal Year: 2013
    ..nigra resulting in dopamine depletion of the striatum, part of the basal ganglia circuitry controlling motor activity and action selection...
    Pinfen Yang; Fiscal Year: 2009
    ..The important questions include how the dynein motor activity is coordinated and how calcium and cyclic nueleotides modulate the dynein-driven motility...
    Grant Hennig; Fiscal Year: 2011
    ..gastric antrum of mouse models of T2DM, then perform high resolution imaging in areas which showed abnormal motor activity and measure changes in the structure and density of ICC in the ICC-MY network...
  35. Multiscale Model of Neural Control of Breathing
    Ilya A Rybak; Fiscal Year: 2013
    ..The respiratory CPG generates rhythmic patterns of motor activity that produce coordinated movements of the respiratory pump (diaphragm, thorax, and abdomen), controlling lung ..
    Stephen M King; Fiscal Year: 2013
    ..The first aim will focus on Lis1 which is known to regulate cytoplasmic dynein motor activity. Lis1 is also present in cilia/flagella and intra-flagella levels of Lis1 are modulated in response to imposed ..
  37. Enzymatic and motor properties of myosin III
    Christopher M Yengo; Fiscal Year: 2012
    ..loop which stimulates autophosphorylation of loop 2 in the motor domain and results in downregulation of motor activity. Phosphatase activity returns the motor to its active state and inactivates the kinase domain...
  38. Mechanisms of age-related motor activity decline in C. elegans
    AO LIN ALLEN HSU; Fiscal Year: 2013
    ..e. functional aging) and an increased likelihood of death at later adult ages. Motor activity decline represents one of the most prominent physiological declines in aging animals and humans...
  39. Identification and Characterization of a Novel Regulator of Dopamine Signaling
    DANIEL BERMINGHAM; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dopamine (DA) signaling modulates multiple behaviors including patterned motor activity, reward seeking and executive function...
  40. Modulation of Colonic Response to Stress by Peripheral CRF2 Receptors
    MILLION MULUGETA; Fiscal Year: 2012
    ..and mechanisms through which peripheral CRF2 activation dampen stress- or CRF-related increases in colonic motor activity and visceral pain will have important clinical implications for functional gut diseases such as IBS, for which ..
  41. Role of microtubule-based transport in neuronal polarity
    JILL C WILDONGER; Fiscal Year: 2011
    ..Next, I will extend my studies in vitro and develop a new dynein motor construct to determine how dynein motor activity is affected by microtubule modifications (Aim 2). To do so, I will collaborate with Dr...
  42. Mitosis, Aneuploidy and Cancer
    Beth A Weaver; Fiscal Year: 2013
    ..These findings may have therapeutic implications, particularly since an inhibitor of CENP-E motor activity is currently in clinical trials...
  43. Endocannabinoid system and inhibition in bipolar disorder
    William Perry; Fiscal Year: 2013
    ..The relationship between CSF HVA and motor activity in BD subjects will also be quantified, enabling confirmation of the role of DA in the disorder and validation ..
  44. Small Molecule Approaches to Studying T. gondii Invasion
    Gary E Ward; Fiscal Year: 2013
    ..Isolated T. gondii motor complexes containing the modified TgMLC1 show decreased motor activity in an in vitro motility assay...
  45. Dual-hit hypothesis of aging-related DA dysfunction
    ..The midbrain dopaminergic neurons, which are important for regulation of motor activity, appear to be especially vulnerable to age-related factors, leading to a specific increase in ..
  46. Role of microtubule-based transport in neuronal polarity
    JILL C WILDONGER; Fiscal Year: 2013
    ..Next, I will extend my studies in vitro and develop a new dynein motor construct to determine how dynein motor activity is affected by microtubule modifications (Aim 2). To do so, I will collaborate with Dr...
  47. The Roles of Endothelial PECAM and the LBRC in Leukocyte Transmigration
    William A Muller; Fiscal Year: 2013
    ..Targeted recycling requires intact microtubules and microtubule molecular motor activity. Aim 2 will test the hypothesis that a specific microtubule molecular motor (kinesin) is required for targeted ..
  48. CRCNS: Analysis of synchronization in hybrid neural circuits
    CARMEN CASTRO CANAVIER; Fiscal Year: 2013
    ..These phenomena underlie central pattern generation for the production of repetitive motor activity such as locomotion and respiration...
  49. Study of Cell Adhesion Through an Analysis of Myosin 7
    Margaret A Titus; Fiscal Year: 2010
    ..The next question is whether M7 motor activity is required for its role in amoeboid adhesion...
  50. Fetal Neurobehavioral Development &Postnatal Continuity
    JANET A DI PIETRO; Fiscal Year: 2012
    ..and neurohormonal (salivary cortisol) activation;fetal measures focus on heart rate and its patterning, motor activity, and the relation between the two...
  51. Preterm Infants'Mu-rhythm Suppression Evaluation Study (PrIMES)
    JULIA MARIE STEPHEN; Fiscal Year: 2013
    ..the following specific aim: To characterize and compare the development of the mu rhythm associated with motor activity in young infants at 3 and 6 months corrected-age in two participant groups: a) healthy full-term infants and b)..
  52. Endocannabinoid transmission in schizophrenia
    Andrea Giuffrida; Fiscal Year: 2013
    ..drugs affect behaviors relevant to schizophrenia (working memory, social interaction and motor activity) in PCP-treated and normal rats, and analyze their underlying pharmacological mechanisms...
  53. Neural pathway of REM sleep atonia
    Jun Lu; Fiscal Year: 2013
    ..tegmental nucleus (SLD) project to the spinal cord inhibitory interneurons, which proposed to suppress the motor activity during REM sleep...
  54. Role of myosin 1e in podocyte biology and renal filtration
    Mira Krendel; Fiscal Year: 2013
    ..We propose a hypothesis that myo1e motor activity is required for its role in normal podocyte functions...
  55. Energy Balance and Neurodegenerative Disease
    Robert G Kalb; Fiscal Year: 2013
    ..This can not be attributed to poor nutrition, hyperthyroidism, fever, excessive motor activity or excessive brown fat activity...
  56. Investigating the generation of mechanical forces during tissue invagination
    ADAM CHRISTOPHER MARTIN; Fiscal Year: 2013
    ..First, we will determine the function of myosin motor activity and actin filament depolymerization during pulsatile contraction...
  57. Synthetic Nanofiber Vaccines for Cocaine Addiction
    Jia Zhou; Fiscal Year: 2013 platform for eliciting high titers of anti-cocaine antibodies and test their efficacy in a mouse motor activity assay...
  58. Microtubule Dynamics and Chromosome Segregation
    LINDA G WORDEMAN; Fiscal Year: 2013
    ..Using hig resolution imaging, selective depletions of kinesins and mutant analogs we will evaluate how kinesin motor activity is used within the mitotic spindle...
  59. Genomic Dissection of Circuit Dynamics
    David J Schulz; Fiscal Year: 2010
    ..of the stomatogastric ganglion by deprivation of descending modulatory inputs results in silencing of pyloric motor activity. However, the isolated circuit is able to restore its excitability and rhythmic properties within 2-3 days...
  60. Functional Analysis of Inhibitory Spinal Cord Interneurons
    Martyn D Goulding; Fiscal Year: 2012
    ..Finally, we will test our hypothesis that V2B INs play an essential role in securing flexor-extensor motor activity in the mammalian locomotor CPG...
  61. Alcohol withdrawal and tonic inhibition in the thalamus.
    ROLA BEKDASH; Fiscal Year: 2013
    ..roles that are often disrupted in chronic alcoholics, including sleep regulation and co-ordination of motor activity. The thalamus can also be involved in motor seizures...
  62. The Relation of Sleep Disturbances and Cognition in Parkinson's Disease
    KARINA STAVISKY; Fiscal Year: 2010
    ..adults (NC) using a self-report sleep scale, a self-report sleepiness scale, two actigraphs that will monitor motor activity during the 24-hour sleep-wake cycle, and a sleep diary...
  63. CRCNS: Organization of the locomotor CPG in the rodent spinal cord
    Ilya A Rybak; Fiscal Year: 2013
    ..genetically defined interneurons during spontaneous and evoked deletions in flexor and/or extensor rhythmic motor activity, to define the possible function of these interneurons in the locomotor CPG...
  64. Re-training locomotor circuitry in a rat model of Spinal Cord Injury
    David S K Magnuson; Fiscal Year: 2010
    ..included, contains complex neuronal circuitry that participates in the generation of the repeating pattern of motor activity (step-cycle) associated with normal over-ground locomotion...
  65. Autonomic consequences of brief seizures
    Mark Stewart; Fiscal Year: 2004
    ..changes are entirely secondary to motor manifestations or if autonomic consequences are independent have motor activity, perhaps even being significant in a non-convulsive seizure...
  66. Function of the Sigma-1 Receptor in Motoneurons
    ARNOLD EINO RUOHO; Fiscal Year: 2013
    ..b>Motor activity)...
  67. Enzymatic and Motor Properties of Myosin 19
    OMAR ALBERTO QUINTERO; Fiscal Year: 2013
    ..and motor characteristics of Myo19 in vitro will allow the determination of the mechanism by which Myo19 motor activity generates force, and determination of factors that may regulate its function in vivo...
  68. Central Cholinergic System, Its History &Current Status
    ALEXANDER KARCZMAR; Fiscal Year: 2002
    ..and their pre-and post-synaptic aspects, central functions with cholinergic correlates such as respiration, motor activity, phases of sleep and endocrine activities; and cholinergically linked behaviors such as addiction, aggression, ..
  69. Primate Model of Stroke and Recovery in Aging
    Tara Moore; Fiscal Year: 2009
    ..observed in late middle age and early senescence, results in cortical injury that frequently affects motor activity of the extremities...
  70. Cone snail venom peptides that modulate zebrafish spinal motor activity
    Joseph Schulz; Fiscal Year: 2009
    ..the fish- hunting cone snail, Conus catus utilizes to subdue its prey through the rapid modulation of spinal motor activity. A prominent neuroexcitatory peptide in the venom of this species,c4a causes repetitive firing in motor ..
  71. Melatonin Receptors as Therapeutic Targets in Primates
    Margarita Dubocovich; Fiscal Year: 2006
    ..The effects of melatonin on sleep parameters, and circadian phase of motor activity and core body temperature will be assessed by actigraphy and radiotelemetry...
  72. Field Measures of Functional Tasks for CIT Intervention
    Paolo Bonato; Fiscal Year: 2006
    ..outcomes to the home and community is currently limited, however, to patient interview measures such as the Motor Activity Log...
    Mitsuo Ikebe; Fiscal Year: 2004
    ..It is well accepted that the motor activity of smooth muscle myosin is regulated by phosphorylation of the regulatory light chain (RLC) at Ser19...
    David He; Fiscal Year: 2004
    ..potentials produced by transducer current in response to acoustic stimulation provide the input to the cell's motor activity. Consequently, the OHC is thought to perform two transducer functions, a conventional mechanoelectrical or ..
    Norman Capra; Fiscal Year: 2005
    ..Altered jaw muscle spindles activity may disturb motor activity and kinesthetic sensibility...