impulsive behavior

Summary

Summary: An act performed without delay, reflection, voluntary direction or obvious control in response to a stimulus.

Top Publications

  1. ncbi Impulsivity, compulsivity, and top-down cognitive control
    Jeffrey W Dalley
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB23EB, UK
    Neuron 69:680-94. 2011
  2. pmc High impulsivity predicts the switch to compulsive cocaine-taking
    David Belin
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 320:1352-5. 2008
  3. pmc Impulsivity as a determinant and consequence of drug use: a review of underlying processes
    Harriet de Wit
    Department of Psychiatry, The University of Chicago, USA
    Addict Biol 14:22-31. 2009
  4. pmc Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
    Barry J Everitt
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 363:3125-35. 2008
  5. ncbi Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies
    Antonio Verdejo-Garcia
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica, Barcelona Biomedical Research Park, Dr Aiguader 88, 08003 Barcelona, Spain
    Neurosci Biobehav Rev 32:777-810. 2008
  6. pmc Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 315:1267-70. 2007
  7. ncbi Evaluation of a behavioral measure of risk taking: the Balloon Analogue Risk Task (BART)
    C W Lejuez
    Department of Psychology, University of Maryland, College Park 20742, USA
    J Exp Psychol Appl 8:75-84. 2002
  8. ncbi Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli
    J D Jentsch
    Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, P O Box 208001, New Haven, CT 06520 8001, USA
    Psychopharmacology (Berl) 146:373-90. 1999
  9. pmc Reconciling the role of serotonin in behavioral inhibition and aversion: acute tryptophan depletion abolishes punishment-induced inhibition in humans
    Molly J Crockett
    Behavioral and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, United Kingdom
    J Neurosci 29:11993-9. 2009
  10. ncbi The neuropharmacology of impulsive behaviour
    Tommy Pattij
    Department of Anatomy and Neurosciences, Center for Neurogenomics and Cognitive Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Trends Pharmacol Sci 29:192-9. 2008

Detail Information

Publications311 found, 100 shown here

  1. ncbi Impulsivity, compulsivity, and top-down cognitive control
    Jeffrey W Dalley
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB23EB, UK
    Neuron 69:680-94. 2011
    ..These results indicate that the vulnerability to stimulant addiction may depend on an impulsivity endophenotype. Implications of these findings for the etiology, development, and treatment of drug addiction are considered...
  2. pmc High impulsivity predicts the switch to compulsive cocaine-taking
    David Belin
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 320:1352-5. 2008
    ..This study shows experimental evidence that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction...
  3. pmc Impulsivity as a determinant and consequence of drug use: a review of underlying processes
    Harriet de Wit
    Department of Psychiatry, The University of Chicago, USA
    Addict Biol 14:22-31. 2009
    ..is an important determinant of drug use during development, and in adults momentary 'state' increases in impulsive behavior may increase the likelihood of drug use, especially in individuals attempting to abstain...
  4. pmc Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
    Barry J Everitt
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 363:3125-35. 2008
    ....
  5. ncbi Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies
    Antonio Verdejo-Garcia
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica, Barcelona Biomedical Research Park, Dr Aiguader 88, 08003 Barcelona, Spain
    Neurosci Biobehav Rev 32:777-810. 2008
    ..Within each of these three lines of enquiry, there is accumulating evidence that impulsivity is a pre-existing vulnerability marker for SUDs...
  6. pmc Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 315:1267-70. 2007
    ..These data demonstrate that trait impulsivity predicts cocaine reinforcement and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences...
  7. ncbi Evaluation of a behavioral measure of risk taking: the Balloon Analogue Risk Task (BART)
    C W Lejuez
    Department of Psychology, University of Maryland, College Park 20742, USA
    J Exp Psychol Appl 8:75-84. 2002
    ..These results indicate that the BART may be a useful tool in the assessment of risk taking...
  8. ncbi Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli
    J D Jentsch
    Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, P O Box 208001, New Haven, CT 06520 8001, USA
    Psychopharmacology (Berl) 146:373-90. 1999
    ..The evidence for cognitive impulsivity in drug abuse associated with dysfunction of the frontostriatal system will be discussed, and an integrative hypothesis for compulsive reward-seeking in drug abuse will be presented...
  9. pmc Reconciling the role of serotonin in behavioral inhibition and aversion: acute tryptophan depletion abolishes punishment-induced inhibition in humans
    Molly J Crockett
    Behavioral and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, United Kingdom
    J Neurosci 29:11993-9. 2009
    ..These findings extend and clarify previous research on the role of serotonin in aversive processing and behavioral inhibition and fit with current theorizing on the involvement of serotonin in predicting aversive outcomes...
  10. ncbi The neuropharmacology of impulsive behaviour
    Tommy Pattij
    Department of Anatomy and Neurosciences, Center for Neurogenomics and Cognitive Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Trends Pharmacol Sci 29:192-9. 2008
    ..However, recent findings also implicate glutamate and cannabinoid neurotransmission in impulsivity. In this review, we will discuss some of the recent developments in the neuropharmacological manipulation of impulsive behaviour...
  11. pmc Dopaminergic network differences in human impulsivity
    Joshua W Buckholtz
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Science 329:532. 2010
    ..Path analysis confirmed that the impact of decreased midbrain D2/D3 autoreceptor availability on trait impulsivity is mediated in part through its effect on stimulated striatal DA release...
  12. ncbi Episodic future thinking reduces reward delay discounting through an enhancement of prefrontal-mediotemporal interactions
    Jan Peters
    NeuroimageNord, Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Neuron 66:138-48. 2010
    ..The present data reveal a mechanism through which neural decision-making and prospection networks can interact to generate future-minded choice behavior...
  13. ncbi The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats
    Andrea Bari
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK
    Nat Protoc 3:759-67. 2008
    ....
  14. pmc Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity
    Buyean Lee
    Department of Psychiatry, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90024, USA
    J Neurosci 29:14734-40. 2009
    ..12 corrected). The findings suggest that low striatal D(2)/D(3) receptor availability may mediate impulsive temperament and thereby influence addiction...
  15. ncbi Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity
    Ahmad R Hariri
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 26:13213-7. 2006
    ..They also highlight a specific neurocognitive mechanism that may contribute to increased risk for addiction...
  16. ncbi The role of impulsive behavior in drug abuse
    Jennifer L Perry
    Minneapolis Medical Research Foundation, S 3, 860, 914 South 8th Street, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 200:1-26. 2008
    ..Impulsivity is a multifaceted construct that has recently been recognized as a factor contributing to enhanced vulnerability to drug abuse...
  17. ncbi Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat
    Emma S J Robinson
    Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:1028-37. 2008
    ....
  18. ncbi Acute administration of d-amphetamine decreases impulsivity in healthy volunteers
    Harriet de Wit
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 27:813-25. 2002
    ..Other measures of impulsive behavior were unaffected...
  19. ncbi Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: specific deficits in 'waiting' versus 'stopping'
    E S J Robinson
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, Cambridge, UK
    Behav Brain Res 196:310-6. 2009
    ..We thus suggest that an inability to bridge delays to future rewards and reward-related stimuli is a candidate behavioural endophenotype that pre-disposes to clinical psychopathology...
  20. ncbi Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, UK
    Psychopharmacology (Berl) 167:304-14. 2003
    ..However, it is not known precisely how serotonin (5-HT) modulates the medial prefrontal cortex (mPFC) to affect cognitive function and behaviour...
  21. ncbi Impulsivity and cigarette smoking: delay discounting in current, never, and ex-smokers
    W K Bickel
    Human Behavioral Pharmacology Laboratory, Department of Psychiatry, 38 Fletcher Place, University of Vermont, Burlington, VT 05401, USA
    Psychopharmacology (Berl) 146:447-54. 1999
    ..Recent studies show problems with alcohol and opioid dependence are associated with rapid discounting of the value of delayed outcomes. Furthermore, discounting may be particularly steep for the drug of dependence...
  22. ncbi Critical involvement of dopaminergic neurotransmission in impulsive decision making
    Marcel M van Gaalen
    Department of Medical Pharmacology, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, Free University Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 60:66-73. 2006
    ..Commonly prescribed for this condition, amphetamine (Adderall), reduces impulsive decision making; however, the neuropharmacologic mechanism of this effect of amphetamine is unclear...
  23. ncbi Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls
    K N Kirby
    Department of Psychology, Bronfman Science Center, Williams College, Williamstown, Massachusetts 01267, USA
    J Exp Psychol Gen 128:78-87. 1999
    ..05). The results lend external validity to the delay-discounting rate as a measure of impulsiveness, a characteristic associated with substance abuse...
  24. ncbi Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholics
    Anne Beck
    Department of Psychiatry, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Biol Psychiatry 66:734-42. 2009
    ..We explored whether functional brain activation during anticipation of incentive stimuli is associated with impulsiveness in detoxified alcoholics and healthy control subjects...
  25. ncbi L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's disease
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB3 9DF, UK
    Neuropsychologia 41:1431-41. 2003
    ....
  26. ncbi The role of impulsivity in the development of substance use and eating disorders
    Sharon Dawe
    School of Applied Psychology, Griffith University, Brisbane, QLD 4111, Australia
    Neurosci Biobehav Rev 28:343-51. 2004
    ..The evidence supporting the existence of two dimensions of impulsivity is reviewed in relation to substance misuse and binge eating...
  27. pmc Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens
    Morgane Besson
    Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 35:560-9. 2010
    ..the nucleus accumbens (NAcb) as an important brain region underlying inter-individual variation in impulsive behavior. Such variation has been linked to decreased dopamine (DA) D2/3 receptor availability in the ventral ..
  28. ncbi Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats
    Leontien Diergaarde
    Center for Neurogenomics and Cognitive Research, Department of Anatomy and Neurosciences, VU Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 63:301-8. 2008
    ..Although heavy smoking has been associated with impulsivity in humans, it is not clear whether poor impulse control represents a risk factor in the etiology of nicotine dependence...
  29. ncbi Dopaminergic modulation of the orbitofrontal cortex affects attention, motivation and impulsive responding in rats performing the five-choice serial reaction time task
    Catharine A Winstanley
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Behav Brain Res 210:263-72. 2010
    ..Furthermore, D(2)-mediated neurotransmission within the OFC could make a more fundamental contribution to cognitive behaviour...
  30. ncbi Neural response to reward anticipation is modulated by Gray's impulsivity
    Tim Hahn
    University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, Germany
    Neuroimage 46:1148-53. 2009
    ....
  31. pmc Dissociable effects of monoamine reuptake inhibitors on distinct forms of impulsive behavior in rats
    Petra J J Baarendse
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Psychopharmacology (Berl) 219:313-26. 2012
    ..However, impulsive behavior is behaviorally and neurally heterogeneous, and several caveats remain in our understanding of the role of ..
  32. ncbi A comparison of multiple 5-HT receptors in two tasks measuring impulsivity
    John C Talpos
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, UK
    J Psychopharmacol 20:47-58. 2006
    ..SB-270146-A had no effect in either paradigm. The results suggest that the 5-csrtt and the delayed reward task do in fact measure different types of impulsive behaviour, which are at least partially neurochemically distinct...
  33. ncbi Impulsive behavior in adults with attention deficit/ hyperactivity disorder: characterization of attentional, motor and cognitive impulsiveness
    L Malloy-Diniz
    Neuropsychology and Neurosciences Research Group, Health Sciences School, FUMEC University, Bairro São Lucas, Brazil
    J Int Neuropsychol Soc 13:693-8. 2007
    ..Most importantly, this study also highlights the complementary nature of self-report questionnaires and neuropsychological tasks in the assessment of impulsivity in ADHD adults...
  34. pmc Insight into the relationship between impulsivity and substance abuse from studies using animal models
    Catharine A Winstanley
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    Alcohol Clin Exp Res 34:1306-18. 2010
    ....
  35. ncbi 5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 176:376-85. 2004
    ..Mounting evidence suggests that 5-HT(2A) and 5-HT(2C) receptors have opposing effects on behaviour, and that the 5-HT(2C) receptor antagonist SB 242084 produces a pattern of behaviour similar to 5-HT depletion...
  36. ncbi Cognitive impulsivity in cocaine and heroin polysubstance abusers
    Antonio J Verdejo-García
    Dept Personalidad, Evaluacion y Tratamiento Psicologico, Universidad de Granada, Campus de Cartuja, S N, 18071 Granada, Spain
    Addict Behav 32:950-66. 2007
    ..These deficits are prominent in different domains associated with cognitive impulsivity, including response inhibition and decision-making. The extent and nature of these deficits may depend on the principal substance of abuse...
  37. ncbi Reward drive and rash impulsiveness as dimensions of impulsivity: implications for substance misuse
    Sharon Dawe
    School of Applied Psychology, Griffith University, Brisbane, Q 4111, Australia
    Addict Behav 29:1389-405. 2004
    ..In this paper, we propose a model that integrates the findings from research into individual differences with recent models of neural substrates implicated in the development of substance misuse...
  38. ncbi Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity
    Y Chudasama
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Behav Brain Res 146:105-19. 2003
    ..Furthermore, these data provide new insights into the functional organization of the rodent frontal cortex with a particular emphasis on localization of function...
  39. ncbi High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence
    Daina Economidou
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge CB2 3EB, United Kingdom
    Biol Psychiatry 65:851-6. 2009
    ..Relapse is a hallmark feature of cocaine addiction and a main challenge for treatment strategies. Human studies indicate a link between impulsivity and increased susceptibility to relapse...
  40. pmc Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits
    Karen D Ersche
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 68:770-3. 2010
    ..However, it has not been clear whether these personality traits are a cause or an effect of stimulant drug dependence...
  41. ncbi μ-Opioid receptors in the nucleus accumbens shell region mediate the effects of amphetamine on inhibitory control but not impulsive choice
    Joost Wiskerke
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, Vrije Universiteit University Medical Center, 1081 BT Amsterdam, The Netherlands
    J Neurosci 31:262-72. 2011
    Acute challenges with psychostimulants such as amphetamine affect impulsive behavior in both animals and humans...
  42. ncbi Childhood onset neuropsychiatric disorders in adult eating disorder patients. A pilot study
    Elisabet Wentz
    Dept of Child and Adolescent Psychiatry, Goteborg University, Kungsgatan 12, 41119, Goteborg, Sweden
    Eur Child Adolesc Psychiatry 14:431-7. 2005
    ..This study aimed to explore the comorbidity of ASD and other childhood onset neuropsychiatric disorders (COND) [attention-deficit/hyperactivity disorder (AD/HD) and tic disorders] in a group of severe eating disorder (ED) patients...
  43. ncbi Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response control
    Tommy Pattij
    Department of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 191:587-98. 2007
    ..Impaired inhibitory control over behavior is a key feature in various psychiatric disorders, and recent studies indicated an important role for dopamine D(1) and D(2) receptors and the nucleus accumbens (Acb) in this respect...
  44. ncbi Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone
    Neil E Paterson
    Behavioral Pharmacology, PsychoGenics, Inc, Tarrytown, NY 10591, USA
    Neurosci Res 69:41-50. 2011
    ..Finally, tolcapone had no effects on sub-optimal performance in the variable ITI 5-CSRTT. These results suggest minimal potential of tolcapone as a therapeutic agent for ADHD and implicate cortical NE, not DA, in impulsive action...
  45. pmc Investigating the behavioral and self-report constructs of impulsivity domains using principal component analysis
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut 06106, USA
    Behav Pharmacol 20:390-9. 2009
    ..In addition, our supplemental analysis also suggested that the impulsivity constructs were largely, but not entirely the same within the healthy and ARA groups...
  46. pmc Another look at impulsivity: a meta-analytic review comparing specific dispositions to rash action in their relationship to bulimic symptoms
    Sarah Fischer
    Psychology Department, University of Georgia, United States
    Clin Psychol Rev 28:1413-25. 2008
    ..Negative urgency appears especially important for BN; more broadly, researchers should consider the role of emotion-based dispositions to rash acts in their risk theories...
  47. pmc Are executive function and impulsivity antipodes? A conceptual reconstruction with special reference to addiction
    Warren K Bickel
    Addiction Recovery Research Center and Virginia Tech Department of Psychology, Virginia Tech Carilion Research Institute, 2 Riverside Circle, Roanoke, VA 24016, USA
    Psychopharmacology (Berl) 221:361-87. 2012
    ..Although there is considerable interest in how either executive function (EF) or impulsivity relate to addiction, there is little apparent overlap between these research areas...
  48. pmc D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking
    C M Helms
    Oregon National Primate Research Center, Division of Neuroscience, Oregon Health and Science University, Portland, OR 97239, United States
    Pharmacol Biochem Behav 90:387-93. 2008
    ..For both genotypes, more impulsive mice habituated less in the novel open field. These data suggest that the absence of D(4)Rs is not sufficient to cause psychopathologies associated with heightened impulsivity and novelty seeking...
  49. pmc Decision making and binge drinking: a longitudinal study
    Anna E Goudriaan
    University of Missouri Columbia, and the Midwest Alcoholism Research Center, Columbia, Missouri 65211, USA
    Alcohol Clin Exp Res 31:928-38. 2007
    ..This study therefore investigated whether binge drinking is related to disadvantageous decision making, as measured by the IGT. We also examined the relation between decision making and impulsivity...
  50. ncbi Associations between trait impulsivity and prepotent response inhibition
    Désirée S Aichert
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Clin Exp Neuropsychol 34:1016-32. 2012
    ..Implications for studies of patient populations with symptoms of impulsivity are discussed...
  51. ncbi Needle sharing in opioid-dependent outpatients: psychological processes underlying risk
    A L Odum
    Department of Psychiatry, Human Behavioral Pharmacology Laboratory, 38 Fletcher Place, University of Vermont, Burlington, 05401, USA
    Drug Alcohol Depend 60:259-66. 2000
    ..Persistent needle sharing may be related to the relative inability of delayed outcomes to impact current behavior. Training to mitigate the effect of delay on outcome value may offer reductions in needle sharing and drug abuse...
  52. pmc Behavioral components of impulsivity predict alcohol consumption in adults with ADHD and healthy controls
    Jessica Weafer
    Department of Psychology, University of Kentucky Lexington, KY 40506 0044, United States
    Drug Alcohol Depend 113:139-46. 2011
    ..Further, the possibility that this relation might be more pronounced in groups characterized by heightened impulsivity (i.e., individuals with ADHD) has not been tested...
  53. ncbi Learning not to be impulsive: disruption by experience of alcohol withdrawal
    Sophie E Walker
    School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Psychopharmacology (Berl) 217:433-42. 2011
    ..There is extensive evidence that alcoholism and impulsivity are related, but the direction of causality is unclear...
  54. pmc Prefrontal and monoaminergic contributions to stop-signal task performance in rats
    Andrea Bari
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 31:9254-63. 2011
    ..This study advances our understanding of the neuroanatomical and neurochemical determinants of impulsivity, which are relevant for a range of psychiatric disorders...
  55. pmc Relationship between impulsivity and decision making in cocaine dependence
    Kimberly L Kjome
    Department of Psychiatry and Behavioral Science, University of Texas Health Science Center at Houston, TX, USA
    Psychiatry Res 178:299-304. 2010
    ..These results suggest that in cocaine-dependent subjects there is little overlap between decision making as measured by the IGT and impulsivity/behavioural inhibition as measured by the BIS and IMT...
  56. ncbi Impulsivity and decision making
    Ariane Zermatten
    Cognitive Psychopathology and Neuropsychology Unit, University of Geneva, Geneva, Switzerland
    J Nerv Ment Dis 193:647-50. 2005
    ..This suggests that premeditation is related to decision making influenced by somatic (or emotional) markers...
  57. ncbi Dorsal-striatal 5-HT₂A and 5-HT₂C receptors control impulsivity and perseverative responding in the 5-choice serial reaction time task
    Laura Agnoli
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Via G La Masa 19, Milan 20156, Italy
    Psychopharmacology (Berl) 219:633-45. 2012
    ..The relationship between 5-HT and aspects of attention and executive control is complex depending on experimental conditions and the level of activation of different 5-HT receptors within the nuclei of corticostriatal circuitry...
  58. ncbi Association of the COMT Met¹⁵⁸ allele with trait impulsivity in healthy young adults
    Márcio Gerhardt Soeiro-de-Souza
    Mood Disorders Unit GRUDA, Department and Institute of Psychiatry, School of Medicine, University of São Paulo HC FMUSP, Sao Paulo, Brazil
    Mol Med Rep 7:1067-72. 2013
    Dopamine (DA) is considered to be an important neurotransmitter in the control of impulsive behavior, however, its underlying mechanisms have not been fully elucidated...
  59. ncbi Altered regional cerebral glucose metabolism in internet game overusers: a 18F-fluorodeoxyglucose positron emission tomography study
    Hyun Soo Park
    Seoul National University College of Medicine, South Korea
    CNS Spectr 15:159-66. 2010
    ....
  60. pmc Adults with a family history of alcohol related problems are more impulsive on measures of response initiation and response inhibition
    Ashley Acheson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Drug Alcohol Depend 117:198-203. 2011
    ..However, drawing conclusions is tenuous because these different measures have not been administered together in the same group of participants...
  61. ncbi Obesity and the four facets of impulsivity
    Olivia Mobbs
    Cognitive Psychopathology and Neuropsychology Unit, Psychology Department, University of Geneva, Switzerland
    Patient Educ Couns 79:372-7. 2010
    ..The objective of this article is to examine how obesity and eating disorder symptoms may be related to the four facets of impulsivity...
  62. ncbi High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress
    Anna C Molander
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 215:721-31. 2011
    ..However, inter-relationships between impulsivity, novelty seeking and anxiety traits are poorly understood...
  63. ncbi Performance on the IOWA card task by adolescents and adults
    William H Overman
    Psychology Department, University of North Carolina, 601 South College Road, Wilmington, NC 28401, USA
    Neuropsychologia 42:1838-51. 2004
    ..Males tended to choose on the basis of long-term outcome. Results are discussed in terms of adolescent brain development and decision-making differences between males and females...
  64. ncbi Remediation of attentional dysfunction in rats with lesions of the medial prefrontal cortex by intra-accumbens administration of the dopamine D(2/3) receptor antagonist sulpiride
    Marie A Pezze
    Department of Experimental Psychology, University of Cambridge, Downing St, Cambridge CB23EB, UK
    Psychopharmacology (Berl) 202:307-13. 2009
    ..The prefrontal cortex (PFC) and nucleus accumbens (NAC) are key brain loci considered to mediate many of the cognitive deficits associated with schizophrenia and related disorders...
  65. ncbi Neurobehavioral mechanisms of impulsivity: fronto-striatal systems and functional neurochemistry
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge, CB2 3EB, UK
    Pharmacol Biochem Behav 90:250-60. 2008
    ..is reviewed from several well-established paradigms with putative utility in assessing distinct forms of impulsive behavior in rodents, including the 5-choice serial reaction time (5CSRT) task and the delay discounting paradigm...
  66. ncbi Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective
    Antoine Bechara
    Institute for the Neurological Study of Emotion and Creativity, Department of Psychology, University of Southern California, Los Angeles, California 90089 2520, USA
    Nat Neurosci 8:1458-63. 2005
    ....
  67. ncbi Dissociable elements of human foresight: a role for the ventromedial frontal lobes in framing the future, but not in discounting future rewards
    Lesley K Fellows
    Center for Cognitive Neuroscience, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Neuropsychologia 43:1214-21. 2005
    ..Apathy may deserve more attention in understanding both impaired future thinking and the impaired decision making that may result...
  68. ncbi Self-rated executive function: development of the executive function index
    Marcello Spinella
    Division of Social and Behavioral Sciences, Richard Stockton College of New Jersey, Pomona, New Jersey 08240 0195, USA
    Int J Neurosci 115:649-67. 2005
    ....
  69. ncbi BMI predicts emotion-driven impulsivity and cognitive inflexibility in adolescents with excess weight
    Elena Delgado-Rico
    Department of Clinical Psychology, Universidad de Granada, Granada, Spain
    Obesity (Silver Spring) 20:1604-10. 2012
    ....
  70. ncbi Preliminary evidence for a role for impulsivity in cognitive disinhibition in bulimia nervosa
    Eva Kemps
    Flinders University, Adelaide, SA 5001, Australia
    J Clin Exp Neuropsychol 32:515-21. 2010
    ....
  71. ncbi Deficits in impulse control associated with tonically-elevated serotonergic function in rat prefrontal cortex
    Jeffrey W Dalley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neuropsychopharmacology 26:716-28. 2002
    Converging lines of evidence suggest that dysfunction of brain serotonergic systems may underlie impulsive behavior. However, the nature of this deficit remains poorly understood because indirect indices of serotonin (5-HT) function are ..
  72. ncbi The neural correlates of intertemporal decision-making: contributions of subjective value, stimulus type, and trait impulsivity
    Chandra Sekhar Sripada
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 2700, USA
    Hum Brain Mapp 32:1637-48. 2011
    ..These findings significantly advance our understanding of the specificity and overlap of functions subserved by different regions involved in intertemporal decision-making, and help to reconcile conflicting accounts in the literature...
  73. ncbi Childhood trauma, impulsivity, and executive functioning in crack cocaine users
    Joana C M Narvaez
    Bipolar Disorders Program and INCT Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre CEP 90035 003, Brazil
    Compr Psychiatry 53:238-44. 2012
    ..This study had the objective of evaluating the relationship of childhood trauma with executive functioning and impulsivity in outpatients with crack cocaine use disorders...
  74. ncbi A systematic review of impulsivity in eating disorders
    Samantha E Waxman
    Department of Psychology, Queen s University, Kingston, Canada
    Eur Eat Disord Rev 17:408-25. 2009
    ..The current findings have important clinical implications for our understanding and treatment of both impulsivity and eating disorders...
  75. pmc Similarities and differences between pathological gambling and substance use disorders: a focus on impulsivity and compulsivity
    Robert F Leeman
    Department of Psychiatry, Yale University School of Medicine, CMHC, 34 Park Street, New Haven, CT 06405, USA
    Psychopharmacology (Berl) 219:469-90. 2012
    ..Specific relationships with impulsivity and compulsivity may be central to understanding PG and SUDs...
  76. ncbi Trait impulsivity and prefrontal gray matter reductions in cocaine dependent individuals
    Laura Moreno-López
    Department of Clinical Psychology, School of Psychology, University of Granada, Spain
    Drug Alcohol Depend 125:208-14. 2012
    ....
  77. pmc The utility of rat models of impulsivity in developing pharmacotherapies for impulse control disorders
    Catharine A Winstanley
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Br J Pharmacol 164:1301-21. 2011
    ..Novel targets within the glutamatergic and serotonergic system are also suggested...
  78. ncbi Borderline personality disorder, impulsivity, and the orbitofrontal cortex
    Heather A Berlin
    Department of Experimental Psychology, University of Oxford
    Am J Psychiatry 162:2360-73. 2005
    ..The authors investigated whether aspects of borderline personality disorder, in particular impulsivity, are associated with orbitofrontal cortex dysfunction...
  79. pmc Impulsiveness and cigarette smoking
    Janine D Flory
    Department of Psychology, Queens College, 65 30 Kissena Blvd, Flushing, NY 11367, USA
    Psychosom Med 71:431-7. 2009
    ..g., any tobacco use versus dependence) or considered more than one variety of impulsiveness simultaneously...
  80. ncbi Asymmetric discounting in intertemporal choice: a query-theory account
    E U Weber
    Columbia University, NY 10027, USA
    Psychol Sci 18:516-23. 2007
    ..The results of Experiment 3, which used an implicit-memory task, support a memory-interference account of the effect of query order...
  81. ncbi Acute yohimbine increases laboratory-measured impulsivity in normal subjects
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, Texas 77030, USA
    Biol Psychiatry 57:1209-11. 2005
    ....
  82. ncbi Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians
    Cindy L Ehlers
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Twin Res Hum Genet 10:805-11. 2007
    ..001), rs2023239 (p = .004), rs1049353 (p < .001) and rs806368 (p < .0006). These studies provide data to suggest that the CNR1 receptor gene may be significantly associated with impulsivity in SWC Indians...
  83. pmc Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants
    Ajna Hamidovic
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA
    Exp Clin Psychopharmacol 17:374-83. 2009
    ..The significant relationship between DRD2 genotype and both behavioral inhibition and impulsivity suggests a possible common genetic influence on behavioral and self-report measures of impulsivity...
  84. pmc Impulsivity predicts the escalation of cocaine self-administration in rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Pharmacol Biochem Behav 93:343-8. 2009
    ..This study suggests that individual differences in impulsivity predict escalation of cocaine self-administration in female rats, which may have implications in the prediction of binge-like patterns of cocaine intake in women...
  85. ncbi Maturation of limbic corticostriatal activation and connectivity associated with developmental changes in temporal discounting
    Anastasia Christakou
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Neuroimage 54:1344-54. 2011
    ....
  86. ncbi Construct validity of the Balloon Analog Risk Task (BART): associations with psychopathy and impulsivity
    Melissa K Hunt
    University of Tennessee Knoxville, 37996, USA
    Assessment 12:416-28. 2005
    ..Findings also revealed interesting gender differences in self-reported psychopathy and a trend for men to engage in riskier behavior. Limitations and research directions are presented...
  87. ncbi Response inhibition and impulsivity: an fMRI study
    N R Horn
    Neuroscience and Psychiatry Unit, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, UK
    Neuropsychologia 41:1959-66. 2003
    ..It may also allow study of the effects of physical and psychological interventions on response inhibition in clinical conditions such as antisocial personality disorder...
  88. ncbi Heroin and cocaine abusers have higher discount rates for delayed rewards than alcoholics or non-drug-using controls
    Kris N Kirby
    Department of Psychology, Williams College, Williamstown, MA, USA
    Addiction 99:461-71. 2004
    ..The delay-discount rate refers to the rate of reduction in the present value of a future reward as the delay to that reward increases...
  89. ncbi Neuropsychological and behavioural disinhibition in adult ADHD compared to borderline personality disorder
    K Lampe
    Department of Psychiatry and Psychotherapy, RWTH Aachen, University Hospital, Rostock, Germany
    Psychol Med 37:1717-29. 2007
    ....
  90. ncbi Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
    J Neurosci 24:4718-22. 2004
    ..This is the first time that lesions to these two structures have produced opposite behavioral effects, indicating their distinct contributions to cognition...
  91. ncbi Sex differences in impulsivity: a meta-analysis
    Catharine P Cross
    Department of Psychology, Durham University, Queens Campus, University Boulevard, Thornaby, Stockton on Tees TS17 6BH, United Kingdom
    Psychol Bull 137:97-130. 2011
    ....
  92. pmc Subthalamic nucleus stimulation influences expression and suppression of impulsive behaviour in Parkinson's disease
    Scott A Wylie
    Neurology Department, University of Virginia Health Systems, Charlottesville, VA 22908, USA
    Brain 133:3611-24. 2010
    ....
  93. ncbi Effects of atomoxetine and methylphenidate on attention and impulsivity in the 5-choice serial reaction time test
    Rachel Navarra
    Discovery Neuroscience, Wyeth Research, 500 Arcola Road, PA 19426 USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:34-41. 2008
    ..Those data suggest that the 5CSRT test can be used to differentiate stimulant and non-stimulant pharmacotherapies on measures of impulsivity...
  94. pmc Intact reward learning but elevated delay discounting in Parkinson's disease patients with impulsive-compulsive spectrum behaviors
    Charlotte R Housden
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 35:2155-64. 2010
    ..Instead, our data are more consistent with a model in which excessive dopaminergic transmission induces a strong preference for immediate over future rewards, driving maladaptive behavior in PD patients with ICBs...
  95. ncbi Integration of impulsivity and positive mood to predict risky behavior: development and validation of a measure of positive urgency
    Melissa A Cyders
    Department of Psychology, University of Kentucky, Lexington, KY 40506 0044, USA
    Psychol Assess 19:107-18. 2007
    ..and showed that positive urgency was distinct from impulsivity-like constructs identified in 2 models of impulsive behavior. In Study 2, they showed that positive urgency explained variance in risky behavior not explained by ..
  96. pmc Gene-environment interactions and response to social intrusion in male and female rhesus macaques
    Melanie L Schwandt
    Laboratory of Clinical and Translational Studies, National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, Poolesville, Maryland, USA
    Biol Psychiatry 67:323-30. 2010
    ..In this study, we investigated the possibility of sex-specific gene-environment interactions in a nonhuman primate model of response to social threat...
  97. pmc Impulsivity characterization in the Roman high- and low-avoidance rat strains: behavioral and neurochemical differences
    Margarita Moreno
    Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almeria, Almeria, Spain
    Neuropsychopharmacology 35:1198-208. 2010
    ..These findings characterize the Roman rat strains as a valid model for studying the different aspects of impulsive behavior and for analyzing the mechanisms involved in individual predisposition to impulsivity and its related ..
  98. ncbi Single units in the pigeon brain integrate reward amount and time-to-reward in an impulsive choice task
    Tobias Kalenscher
    Department of Biopsychology, Institute of Cognitive Neuroscience, GAFO 05 618, Ruhr University Bochum, Universitatsstrasse 150, 44780 Bochum, Germany
    Curr Biol 15:594-602. 2005
    ..Despite increasing knowledge about the pharmacology and anatomy underlying impulsivity, it is still unknown how the brain combines reward amount and time-to-reward information to represent subjective reward value...
  99. ncbi Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 29:1331-43. 2004
    Reducing levels of 5-HT in the central nervous system has been associated with increases in impulsive behavior. However, the impulsivity construct describes a wide range of behaviors, including the inability to withhold a response, ..
  100. ncbi Differences in risk-taking propensity across inner-city adolescent ever- and never-smokers
    C W Lejuez
    Department of Psychlogy, University of Maryland, College Park, MD 20742, USA
    Nicotine Tob Res 7:71-9. 2005
    ..e., self-report measures and behavioral tasks) to identify adolescents' risk-taking susceptibilities and engagement in smoking and other risk-taking behaviors...
  101. ncbi Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in rats
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 170:320-31. 2003
    ..Although most behavioural effects of amphetamine are attributed to the dopaminergic system, some recent evidence suggests a role for serotonin in this paradoxical "calming" effect...

Research Grants67

  1. Early social stress, novelty seeking, and impulsive behavior
    David M Lyons; Fiscal Year: 2013
    ..whether early social stress increases anticipatory impulsivity without impairing non-anticipatory forms of impulsive behavior. The studies designed to address these aims will provide mechanistic insights for understanding the pathways ..
  2. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..Since the serotonin system mediates impulsive behavior and aggression, it has been reasoned that androgens act on the serotonin system to reduce serotonin and ..
  3. Genetic and Optogenetic Models to Dissect the Role of the Serotonin 1B Receptor
    Katherine M Nautiyal; Fiscal Year: 2013
    ..The serotonin 1B receptor (5-HT1B R) has been implicated in aggressive and impulsive behavior using pharmacology, constitutive knock-out mouse models, and human gene polymorphism association studies...
  4. Neurobehavioral and fMRI Research in HIV Infection and Cocaine Dependence
    Christina S Meade; Fiscal Year: 2013
    ..to the high prevalence of co-occurring HIV infection and stimulant abuse, and the high rates of risky and impulsive behavior in this population...
  5. Adolescence, Impulsivity, and Drug Abuse: Sex/Hormones
    Marilyn E Carroll; Fiscal Year: 2012
    ..behaviors will be compared to the results of the impulsivity tests to determine whether they covary with impulsive behavior and have predictive value;such as, extinction and reinstatement (Ext/Reinst) of drug-seeking behavior (..
  6. COMT Genotype and Risky Decision Making in HIV and Methamphetamine Dependence
    Mariana Cherner; Fiscal Year: 2010
    ..DA) is the primary neurotransmitter involved in the brain's reward system and is associated with impulsive behavior, hypersexuality, and many aspects of cognitive functioning, all of which contribute to decision-making ..
  7. Delay Discounting in Children with ADHD: Neuroimaging and Behavioral Correlates
    Keri Shiels Rosch; Fiscal Year: 2013
    ..to improved understanding of the behavior dysregulation which characterizes ADHD, and more generally impulsive behavior, with the ultimate goal of improving the identification of and outcomes for individuals with this ..
  8. Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol
    David W Crabb; Fiscal Year: 2013
    ..family history of alcohol use disorders (AUD), externalizing behaviors (including different forms of impulsive behavior), patterns of binge drinking, and GABRA2 alleles) and: 1) measures of craving alcohol (assessed by operant ..
  9. Characterizing Two Distinct ADHD Neurobiologies with fMRI
    Michael C Stevens; Fiscal Year: 2012
    ..There is evidence from cognitive studies of ADHD youth that impulsive behavior may arise from two markedly different types of neurobiological dysfunction...
  10. Presynaptic Mechanisms for Variability in Human Dopamine Function and Impulsivity
    JOSHUA WILLIAM BUCKHOLTZ; Fiscal Year: 2012
    ..pathways that translate causal risk factors into deleterious decision-making biases and manifestly impulsive behavior. To that end, we have recently reported several findings suggesting a novel systems-level biological ..
  11. CSIA-Center for the Study of Impulsivity in Addiction
    Kelvin O Lim; Fiscal Year: 2010
    ..The proposed Center for the Study of Impulsivity in Addiction (CSIA) will focus on impulsive behavior, the GABA system, and neuroimaging in addiction-prone and -resistant individuals...
  12. Early experience and low 5-HT markers in alcohol abuse
    Mark Laudenslager; Fiscal Year: 2009
    ..maternal care during development will demonstrate increased risk for the expression of aggressive and impulsive behavior patterns as adolescents...
  13. Combined effects of alcohol and caffeine on agency judgment, impulsivity and risk
    ADRIENNE JULIE HEINZ; Fiscal Year: 2011
    ..We predict that individuals who drink alcohol and caffeine will manifest less risky and impulsive behavior to the extent that caffeine does, or is expected to, mitigate the cognitive impairments induced by alcohol ..
  14. The genetic basis of impulsive behavior in humans
    Harriet de Wit; Fiscal Year: 2013
    ..Here, the investigators will examine the two main components of impulsive behavior: Impulsive Choice (maladaptive decision-making) and Impulsive Action (i.e...
  15. Neurobiological consequences of binge alcohol consumption in young adults
    Marisa M Silveri; Fiscal Year: 2013
    ..improvements in frontally mediated decision-making and response inhibition abilities, while decreasing impulsive behavior. Previous work has identified that heavy alcohol consumption is associated with structural and functional ..
  16. NMDA receptor NR2D subtype-selective allosteric modulator for the treatment of im
    YUELIAN XU; Fiscal Year: 2013
    ..like properties and establish their therapeutic potential by demonstrating efficacy in an animal model of impulsive behavior (the five choice serial reaction time task or 5-CSRTT) that is used industry wide for screening drugs to ..
  17. Translational Addiction Sciences Center
    Kathryn A Cunningham; Fiscal Year: 2013
    ..progressive nature of this disorder stymies efforts to stay abstinent with relapse oft precipitated by impulsive behavior and craving in the face of exposure to cocaine-associated cues (cue reactivity)...
  18. Impact of In Utero Cocaine Exposure on Vulnerability to Drug Abuse in Monkeys.
    Michael A Nader; Fiscal Year: 2012
    ..no preclinical studies involving nonhuman primates that assessed the effects of prenatal cocaine exposure on impulsive behavior and vulnerability to cocaine abuse...
  19. Developmental Origins of Aggressive and Impulsive Behavior
    MARK SASCHA ANSORGE; Fiscal Year: 2013
    ..Together with the mechanistic insight we will provide, our data could lead to improved diagnosis, prevention and treatment strategies in psychiatry. ..
  20. Determining the neurological and behavioral substrates of ethanol and discounting
    Travis M Moschak; Fiscal Year: 2013
    ..and magnitude circuits and how drugs (including but not limited to ethanol) interact with them to increase impulsive behavior. Additional research may expand the examined circuitry to include other measures of impulsivity, as well as ..
  21. Alcohol Binging: Disruptions in Impulse Control and 5-HT as Underlying Mechanisms
    Nathalie Hill-Kapturczak; Fiscal Year: 2012
    ..This study will yield data to clarify the role of impulsive behavior and serotonin function as mechanisms that contribute to the maintenance of an alcohol binge-drinking episode...
  22. A Translational Model of Mood-Based Drug Abuse
    Cassandra D Gipson; Fiscal Year: 2010
    ..This work will advance our basic knowledge about the neural mechanisms of impulsive behavior and drug abuse.
  23. Impulsive Behavior in Adolescent Health Weight and Obese Smokers and Nonsmokers
    SHERECCE ANTOINETTE FIELDS; Fiscal Year: 2013
    ..Results from this additional aim may improve interpretation of our primary question, by allowing the exploration of specific eating motivations and behaviors both across and within the different weight- and smoking-status categories. ..
  24. Genetic influences on developmental heterogeneity of alcohol use disorder
    Alexis C Edwards; Fiscal Year: 2013
    ..g., one associated with impulsive behavior, another with depressive symptoms, etc...
  25. A Web-Based Intervention with Adolescent Smokers of Appalachian Ohio
    BRADY A REYNOLDS; Fiscal Year: 2010
    ..A secondary goal of this research is to explore pre-treatment assessments of different dimensions of impulsive behavior as predictors of treatment outcome...
  26. PRENATAL PCB EXPOSURE AND COGNITIVE DEVELOPMENT
    Paul Stewart; Fiscal Year: 2013
    ..2006;Preliminary Studies). This investigative team has shown a link between exposure to PCBs and impulsive behavior, or more specifically, impaired response inhibition (Stewart et al. 2003, 2005, 2006)...
  27. Impulsivity and Stimulant Response in Early- and Late-Onset CD with Comorbid ADHD
    Charles W Mathias; Fiscal Year: 2013
    ..of this study is to determine the dose-response effects of methylphenidate treatment on laboratory-measured impulsive behavior of two groups of adolescents, those with either childhood- or adolescent-onset Conduct Disorder comorbid ..
  28. Implicit Attitudes and HIV Risk Behavior in Virtual Environments
    Kerry L Marsh; Fiscal Year: 2012
    ..and in university laboratories are designed to test the personal, social, and environmental factors that cue impulsive behavior. In each experiment, implicit measures of attitudes are hypothesized to predict participants'HIV risk- ..
  29. Role of orexin (hypocretin) in impulsive behavior
    John W Muschamp; Fiscal Year: 2013
    ..Conversely, in Aim 4 genetically elevated orexin is predicted to increase impulsive behavior. In Aim 5, it is anticipated that high-impulsive rats will show higher Fos expression in orexin neurons and ..
  30. PRENATAL PCB EXPOSURE AND COGNITIVE DEVELOPMENT
    Paul Stewart; Fiscal Year: 2010
    ..This goal is informed recent data by which show that prenatal PCB exposure predicts impulsive behavior and impaired inhibitory control from ages 4 years through 13 years of age...
  31. Impulsivity and Biological Markers for Suicidality and Drug Use in Adolescents
    Donald M Dougherty; Fiscal Year: 2012
    ..Furthermore, the relationships between impulsive behavior and 5-HT, while often included in theories of suicide, have not been firmly established...
  32. Consequences of Adolescent Substance Use on the Development of Impulse Control
    Donald M Dougherty; Fiscal Year: 2013
    ..Healthy adolescence is defined by an increasing ability to control impulsive behavior. Deviations from normal development that are produced by substance use and environmental factors are thought ..
  33. Impulsive Behavior and Treatment Outcomes for Adolescent Smoking
    BRADY A REYNOLDS; Fiscal Year: 2012
    ..applicant): The primary goal of this research is to assess the relationships between different dimensions of impulsive behavior and treatment response for adolescent smokers receiving treatment to quit or reduce their smoking...
  34. Neural substrates of impulsive behavior in methamphetamine dependence
    ANGELICA MARIE MORALES; Fiscal Year: 2013
    ..The overarching goal of the proposed work is to help clarify the neural networks that underlie impulsive behavior and to determine how the structural integrity of these networks influences impulsive behaviors in healthy ..
  35. Cerebro-Cerebellar Contributions to Cognitive Function in Drug Addiction
    Cherie L Marvel; Fiscal Year: 2013
    ..to drug addiction because impairments of executive control over behavior are thought to lead to risky and impulsive behavior. The proposed research will characterize the function and interdependence of specific nodes within the ..
  36. Web-Based Contingency Management for Smoking Abstinence with Adolescents
    BRADY A REYNOLDS; Fiscal Year: 2013
    ..A secondary goal of this research is to explore pre-treatment assessments of different dimensions of impulsive behavior as predictors of treatment outcome...
  37. Future Self Simulation and Substance Abuse
    Adam Waytz; Fiscal Year: 2010
    ..relationship than previous models of impulsivity, and potentially provide an intervention to reduce this impulsive behavior. PUBLIC HEALTH RELEVANCE: The proposed research tests the extent to which impulsivity increases substance ..
  38. Sustained-Release Naltrexone for Opioid Dependence: Longitudinal Study in Humans
    Sandra D Comer; Fiscal Year: 2010
    ..Specifically, impulsive behavior will be measured before and repeatedly after administration of the naltrexone implant...
  39. Neural mechanisms and social influence in delay discounting and impulsive choice
    Jonathan D Cohen; Fiscal Year: 2010
    ..of these mechanisms, in an effort to better understand the mechanisms that mediate social influences on impulsive behavior. An understanding of the neural mechanisms underlying impulsivity, and how these are impacted by social ..
  40. BEHAVIORAL MECHANISM IN HIGH RISK POPULATIONS
    DON CHEREK; Fiscal Year: 2001
    ..mechanisms operating in certain individuals who exhibit high or low probabilities of aggressive and/or impulsive behavior. Members of the three behaviorally defined groups will be described in terms of diagnostic categories: ..
  41. Long-Term Cocaine Effects on Impulsive Choice and Orbitofrontal Cortex Activity
    NICHOLAS SIMON; Fiscal Year: 2009
    ..b>Impulsive behavior in drug abusers is associated with structural and functional changes in the orbitofrontal cortex, a frontal ..
  42. ALTERING BEHAVIORAL RISK FOR DRUG DEPENDENCE
    DON CHEREK; Fiscal Year: 2001
    ..We propose to examine the alteration of aggressive and impulsive behavior under controlled laboratory conditions employing drugs which have been used to treat patients with similar ..
  43. Development of a Novel Trial-by-Trial Consequence Human Delay Discounting Task
    Matthew Johnson; Fiscal Year: 2009
    ..resulting from cocaine abuse is known to result in public health harms, including the spread of HIV, through impulsive behavior, this study should ultimately lead to important information for cocaine prevention and treatment efforts.
  44. Activation of Neuronal Networks Related to Risk for Addiction: A fMRI Study
    Iliyan Ivanov; Fiscal Year: 2009
    ..activation in brain areas associated with reward circuitry and regulatory control networks associated with impulsive behavior, and to study the contribution of these neural systems to the pathophysiology of addiction in at risk pre-..
  45. Frontal White Matter and Impulsivity in Schizophrenia
    Matthew Hoptman; Fiscal Year: 2007
    b>Impulsive behavior in the mentally ill carries tremendous costs including increased violence risk lengthened hospital stays, increased ward turmoil, and complicated treatment planning...
  46. MONOAMINE PREDICTORS OF DRUG ABUSE/SOCIOPATHY
    Roy King; Fiscal Year: 1992
    ..be related to a low level of aversive arousal in the face of internally and externally imposed restraints on impulsive behavior, it may be that a subgroup of substance abusers share this tendency for low aversive arousal...
  47. SOCIAL RISK AND SELF REGULATION PROBLEMS IN CHILDHOOD
    Sheryl Olson; Fiscal Year: 2002
    DESCRIPTION (Adapted from applicant's abstract): Aggressive impulsive behavior is a normal characteristic of pre-school children that dissipates during middle-childhood as they develop more advanced self-regulation abilities...
  48. CHRONIC METHAMPHETAMINE ADMINISTRATION
    LEWIS SEIDEN; Fiscal Year: 1999
    ..that transmitter depletions seen after drug administration lead to changes in reaction time or increased impulsive behavior in rats...
  49. Genetic Variation in Amphetamine Response
    Ajna Hamidovic; Fiscal Year: 2009
    ..in healthy volunteers, in three domains: i) subjective or mood altering effects, ii) effects of the drug on impulsive behavior, and iii) effects of the drug on other measures of cognition...
  50. IMPULSIVITY--PRECURSOR AND SEQUEL OF TOXICANT EXPOSURE
    FRANS VAN HAAREN; Fiscal Year: 2000
    ..suggested that prolonged (prenatal) exposure to environmental toxicants (lead, for instance) may result in impulsive behavior, which may then facilitate further drug abuse, or hamper 'normal' development...
  51. Smoking Abstinence and Impulsive Behavior: A Multi-Process Model
    REBECCA ASHARE; Fiscal Year: 2009
    ..use have proposed a self-medication model in which abstinence-related deficits may potentially lead to impulsive behavior. However, impulsivity is a broadly defined construct making it difficult to determine which dimensions are ..
  52. DISCOUNTING MODELS OF IMPULSIVENESS AND SELF CONTROL
    KRIS KIRBY; Fiscal Year: 2000
    ..The broad long-term objectives of the proposed research are: (1) to refine the discounting model of impulsive behavior through a systematic investigation of the quantitative form of the discounting function and the variables ..
  53. Cholinergic Effects on Inhibition and Delay in ADHD
    Alexandra Potter; Fiscal Year: 2005
    ..Recent evidence suggests that two models of the cognitive underpinnings of impulsive behavior, the behavioral inhibition model (Bl) and the delay aversion (DA) model, contribute independently to ADHD ..
  54. Impulsivity and Emotion Dysregulation in BPD
    SCOTT COFFEY; Fiscal Year: 2006
    ..by using psychophysiological methods to more thoroughly measure emotion, and laboratory measures to assess impulsive behavior, theoretical models of BPD can be further developed and refined...
  55. A PC Based Low Cost Stimulator for Driver's Education
    R WADE ALLEN; Fiscal Year: 2002
    ..Cognitive test data will be obtained from all subjects to be used for classification purposes (e.g. impulsive behavior)...
  56. Social skills training for aggressive adolescents
    MELISSA DEROSIER; Fiscal Year: 2003
    ..PF will build on S.S.GRIN and extend skill training for decreasing antisocial and impulsive behavior and more directly address social triggers for aggression, such as bullying...
  57. Waiting for a better future: Deciding when to "cash in" when outcomes are continu
    MICHAEL E contact YOUNG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The proposed research extends prior work on impulsive behavior and delay discounting...
  58. Models of Impulsive Behavior in Mice
    Jerry Richards; Fiscal Year: 2003
    ..objective of the proposed research is to adapt three procedures that we are currently using to measure impulsive behavior in rats to mice and to standardize these procedures in mice using parametric and pharmacological ..
  59. Norepinephrine and Impulsivity
    Alan Swann; Fiscal Year: 2009
    ..Most existing knowledge concerns impulsivity as a stable trait rather than the near term likelihood of impulsive behavior. The overall hypothesis of this proposal is that state-dependent flucutations in impulsivity are related to ..
  60. Regulating Approach Impulses:Implications of Orbitofrontal Function for Addiction
    JENNIFER BEER; Fiscal Year: 2005
    ..a basis for developing a larger program of research aimed at understanding the neural basis of addictive, impulsive behavior. Ultimately, this reseach program will have important implications for developing both cognitive and ..
  61. Dopamine D4 Receptor in Sustained Attention
    Kehong Zhang; Fiscal Year: 2003
    ..Attention-deficit/hyperactivity disorder (ADHD) is a common disorder of attention, hyperactivity and excessive impulsive behavior. Although the cause of this syndrome is unknown, genetic factors contribute strongly to its etiology...
  62. Fluoxetine and Divalproex:Treatment Correlates in Intermittent Explosive Disorder
    EMIL COCCARO; Fiscal Year: 2007
    ..Duration of treatment will be twelve weeks. ..
  63. Impulsive Aggression : A Twin Study of Behavior and 5-HT
    EMIL COCCARO; Fiscal Year: 2006
    ..abstract_text> ..
  64. Social Information Processing: Assessment Development
    EMIL COCCARO; Fiscal Year: 2007
    ..Development of such measures is critical for the further scientific study of SIP and for its integration in neurobiologhical research. [unreadable] [unreadable]..
  65. Intermittent Explosive Disorder: A Family Study
    EMIL COCCARO; Fiscal Year: 2005
    ..e., relatives of IED probands with and without IED). ..
  66. TREATMENT FOR DUALLY DEPENDENT METHADONE PATIENTS
    Nancy Petry; Fiscal Year: 2002
    ....
  67. Mood and Substance Use Among College Students
    Jeffrey Simons; Fiscal Year: 2003
    ..Better understanding of the etiological paths of substance use problems may be useful for early identification of individuals at risk for substance use problems and may inform the development of effective interventions. ..