patient compliance

Summary

Summary: Voluntary cooperation of the patient in following a prescribed regimen.

Top Publications

  1. ncbi Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence
    M R DiMatteo
    Department of Psychology, University of California, Riverside, CA 92521, USA
    Arch Intern Med 160:2101-7. 2000
  2. ncbi Adherence to medication
    Lars Osterberg
    General Medicine Division, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    N Engl J Med 353:487-97. 2005
  3. ncbi Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
    JAMA 296:679-90. 2006
  4. ncbi Medication compliance and persistence: terminology and definitions
    Joyce A Cramer
    Yale University School of Medicine, New Haven, CT, USA
    Value Health 11:44-7. 2008
  5. pmc Mortality of patients lost to follow-up in antiretroviral treatment programmes in resource-limited settings: systematic review and meta-analysis
    Martin W G Brinkhof
    Division of International and Environmental Health, Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    PLoS ONE 4:e5790. 2009
  6. pmc Adherence in internet interventions for anxiety and depression
    Helen Christensen
    Centre for Mental Health Research, Australian National University, Canberra ACT 0200, Australia
    J Med Internet Res 11:e13. 2009
  7. pmc Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders
    Cristian Pop-Eleches
    School of International and Public Affairs, Columbia University, New York, New York, USA
    AIDS 25:825-34. 2011
  8. ncbi Adherence to a Mediterranean diet and survival in a Greek population
    Antonia Trichopoulou
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    N Engl J Med 348:2599-608. 2003
  9. pmc Patient adherence to tuberculosis treatment: a systematic review of qualitative research
    Salla A Munro
    South African Cochrane Centre, Medical Research Council of South Africa, Cape Town, South Africa
    PLoS Med 4:e238. 2007
  10. pmc Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates
    Frank M Sacks
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 360:859-73. 2009

Detail Information

Publications320 found, 100 shown here

  1. ncbi Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence
    M R DiMatteo
    Department of Psychology, University of California, Riverside, CA 92521, USA
    Arch Intern Med 160:2101-7. 2000
    ..This article presents a quantitative review and synthesis of studies correlating medical patients' treatment noncompliance with their anxiety and depression...
  2. ncbi Adherence to medication
    Lars Osterberg
    General Medicine Division, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    N Engl J Med 353:487-97. 2005
  3. ncbi Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
    JAMA 296:679-90. 2006
    ..Concerns about incomplete adherence among patients living in poverty have been an important consideration in expanding the access to antiretroviral therapy in sub-Saharan Africa...
  4. ncbi Medication compliance and persistence: terminology and definitions
    Joyce A Cramer
    Yale University School of Medicine, New Haven, CT, USA
    Value Health 11:44-7. 2008
    ..The aim of the study is to provide guidance regarding the meaning and use of the terms "compliance" and "persistence" as they relate to the study of medication use...
  5. pmc Mortality of patients lost to follow-up in antiretroviral treatment programmes in resource-limited settings: systematic review and meta-analysis
    Martin W G Brinkhof
    Division of International and Environmental Health, Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    PLoS ONE 4:e5790. 2009
    ..The retention of patients in antiretroviral therapy (ART) programmes is an important issue in resource-limited settings. Loss to follow up can be substantial, but it is unclear what the outcomes are in patients who are lost to programmes...
  6. pmc Adherence in internet interventions for anxiety and depression
    Helen Christensen
    Centre for Mental Health Research, Australian National University, Canberra ACT 0200, Australia
    J Med Internet Res 11:e13. 2009
    ..We need to understand more about adherence in order to maximize the impact of Internet-based interventions on the disease burden associated with common mental disorders...
  7. pmc Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders
    Cristian Pop-Eleches
    School of International and Public Affairs, Columbia University, New York, New York, USA
    AIDS 25:825-34. 2011
    ..This study tested the efficacy of short message service (SMS) reminders on adherence to ART among patients attending a rural clinic in Kenya...
  8. ncbi Adherence to a Mediterranean diet and survival in a Greek population
    Antonia Trichopoulou
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    N Engl J Med 348:2599-608. 2003
    ..Adherence to a Mediterranean diet may improve longevity, but relevant data are limited...
  9. pmc Patient adherence to tuberculosis treatment: a systematic review of qualitative research
    Salla A Munro
    South African Cochrane Centre, Medical Research Council of South Africa, Cape Town, South Africa
    PLoS Med 4:e238. 2007
    ..The aim of this systematic review of qualitative studies was to understand the factors considered important by patients, caregivers and health care providers in contributing to TB medication adherence...
  10. pmc Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates
    Frank M Sacks
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 360:859-73. 2009
    ..The possible advantage for weight loss of a diet that emphasizes protein, fat, or carbohydrates has not been established, and there are few studies that extend beyond 1 year...
  11. ncbi Hunger, waiting time and transport costs: time to confront challenges to ART adherence in Africa
    A P Hardon
    University of Amsterdam, Amsterdam School for Social Science Research, Amsterdam, The Netherlands
    AIDS Care 19:658-65. 2007
    ....
  12. ncbi Dropout from Internet-based treatment for psychological disorders
    Katherine M Melville
    Psychological Health Research Unit, Griffith Institute of Health and Medical Research, Griffith University, Brisbane, Queensland, Australia
    Br J Clin Psychol 49:455-71. 2010
    ....
  13. ncbi Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient Care Committee & Adherence Working Group of the Outcomes Committee of the Adult AIDS Clinical Trials Group (AACTG
    M A Chesney
    Department of Medicine, University of California, San Francisco 94105, USA
    AIDS Care 12:255-66. 2000
    ..Responses to the questionnaires were favourable. These questionnaires have been included in six AACTG clinical trials to date and have been widely disseminated to investigators both in the USA and abroad...
  14. ncbi Internet-based treatment of depression: a randomized controlled trial comparing guided with unguided self-help
    Thomas Berger
    Department of Clinical Psychology and Psychotherapy, University of Bern, Bern, Switzerland
    Cogn Behav Ther 40:251-66. 2011
    ..However, all participants were interviewed in a structured diagnostic telephone interview before inclusion, which prohibits conclusions regarding unguided treatments that are without any human contact...
  15. pmc Supportive accountability: a model for providing human support to enhance adherence to eHealth interventions
    David C Mohr
    Department of Preventive Medicine, Northwestern University, Chicago, IL, United States
    J Med Internet Res 13:e30. 2011
    ..Each component of the proposed model is a testable hypothesis. As we develop viable human support models, these should be manualized to facilitate dissemination...
  16. pmc An online community improves adherence in an internet-mediated walking program. Part 1: results of a randomized controlled trial
    Caroline R Richardson
    Department of Family Medicine, University of Michigan, Ann Arbor, MI 48104 1213, United States
    J Med Internet Res 12:e71. 2010
    ..However, the impact of some Internet-mediated programs is limited by high attrition rates. Online communities that allow participants to communicate with each other by posting and reading messages may decrease participant attrition...
  17. ncbi A comparison study of multiple measures of adherence to HIV protease inhibitors
    H Liu
    Division of General Internal Medicine and Health Service Research, 911 Broxton Plaza, Room 102, Los Angeles, CA 90095 1736, USA
    Ann Intern Med 134:968-77. 2001
    ..Poor adherence to HIV protease inhibitors may compromise the effectiveness of treatment. Few studies have compared methods for measuring adherence or have related adherence measures to a clinical outcome...
  18. pmc Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review
    Sydney Rosen
    Center for International Health and Development, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 4:e298. 2007
    ..In this paper we present a systematic review of patient retention in ART programs in sub-Saharan Africa...
  19. pmc Adherence to Mediterranean diet and health status: meta-analysis
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    BMJ 337:a1344. 2008
    ..To systematically review all the prospective cohort studies that have analysed the relation between adherence to a Mediterranean diet, mortality, and incidence of chronic diseases in a primary prevention setting...
  20. pmc Self-monitoring in weight loss: a systematic review of the literature
    Lora E Burke
    School of Nursing and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Am Diet Assoc 111:92-102. 2011
    ..This review highlights the need for studies in more diverse populations, for objective measures of adherence to self-monitoring, and for studies that establish the required dose of self-monitoring for successful outcomes...
  21. pmc A meta-analysis of the association between adherence to drug therapy and mortality
    Scot H Simpson
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2N8
    BMJ 333:15. 2006
    ..To evaluate the relation between adherence to drug therapy, including placebo, and mortality...
  22. ncbi Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population
    D R Bangsberg
    Epidemiology and Prevention Interventions Center, Division of Infectious Diseases, San Francisco General Hospital, University of California San Francisco, 94110, USA
    AIDS 14:357-66. 2000
    ..To examine the relationship between adherence, viral suppression and antiretroviral resistance in HIV-infected homeless and marginally housed people on protease inhibitor (PI) therapy...
  23. pmc Antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in southern Africa
    Jean B Nachega
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 51:65-71. 2009
    ..To determine adherence to and effectiveness of antiretroviral therapy (ART) in adolescents vs. adults in southern Africa...
  24. ncbi Patient adherence to treatment: three decades of research. A comprehensive review
    E Vermeire
    Centre for General Practice, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    J Clin Pharm Ther 26:331-42. 2001
    ....
  25. ncbi Adherence to antiretroviral treatment in HIV-positive patients in the Cameroon context: promoting the use of medication reminder methods
    Perrine Roux
    INSERM, U912, SE4S, Marseille, Bouches du rhone, France
    J Acquir Immune Defic Syndr 57:S40-3. 2011
    ..Antiretroviral treatment (ART) scale-up in sub-Saharan Africa has made it possible to investigate the maintenance of adherence to HIV medications. We describe here adherence to ART and identify its correlates in the Cameroonian context...
  26. pmc Adherence to continuous positive airway pressure therapy: the challenge to effective treatment
    Terri E Weaver
    Division of Biobehavioral and Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104 6096, USA
    Proc Am Thorac Soc 5:173-8. 2008
    ..Emerging data suggest that various behavioral interventions may be effective in improving CPAP adherence...
  27. ncbi Patients' beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness
    R Horne
    Centre for Health Care Reserach, University of Brighton, UK
    J Psychosom Res 47:555-67. 1999
    ....
  28. pmc Retention in care among HIV-infected patients in resource-limited settings: emerging insights and new directions
    Elvin H Geng
    Division of HIV AIDS at San Francisco General Hospital, 995 Potrero Avenue, San Francisco, CA 94110, USA
    Curr HIV/AIDS Rep 7:234-44. 2010
    ..Research to assess and improve retention in care for HIV-infected patients can be strengthened by incorporating novel methods such as sampling-based approaches and a causal analytic framework...
  29. pmc Using internet and mobile phone technology to deliver an automated physical activity program: randomized controlled trial
    Robert Hurling
    Unilever Corporate Research, Colworth, Bedford, United Kingdom
    J Med Internet Res 9:e7. 2007
    ....
  30. ncbi Responses to a 1 month self-report on adherence to antiretroviral therapy are consistent with electronic data and virological treatment outcome
    John C Walsh
    St Stephen s Centre, Chelsea and Westminster Hospital, London, UK
    AIDS 16:269-77. 2002
    ..The Medication Adherence Self-Report Inventory (MASRI) has been developed and tested for its validity against objective measures and treatment outcome...
  31. pmc Transportation costs impede sustained adherence and access to HAART in a clinic population in southwestern Uganda: a qualitative study
    David M Tuller
    School of Public Health, University of California at Berkeley, Berkeley, CA, USA
    AIDS Behav 14:778-84. 2010
    ..Our findings suggest that transportation costs can compromise both ARV adherence and access to care. Interventions that address this barrier will be important to ensure the success of ARV programs in sub-Saharan Africa...
  32. ncbi Rapid scale-up of antiretroviral therapy at primary care sites in Zambia: feasibility and early outcomes
    Jeffrey S A Stringer
    Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, USA
    JAMA 296:782-93. 2006
    ..The Zambian Ministry of Health has scaled-up human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) care and treatment services at primary care clinics in Lusaka, using predominately nonphysician clinicians...
  33. ncbi Patient adherence and medical treatment outcomes: a meta-analysis
    M Robin Dimatteo
    Department of Psychology, University of California, Riverside, California 92521, USA
    Med Care 40:794-811. 2002
    ..Adherence is a factor in the outcome of medical treatment, but the strength and moderators of the adherence-outcome association have not been systematically assessed...
  34. pmc Pragmatic controlled clinical trials in primary care: the struggle between external and internal validity
    Marshall Godwin
    Centre for Studies in Primary Care, Queen s University, Kingston K7L 5E9, Canada
    BMC Med Res Methodol 3:28. 2003
    ..We describe the design of the trials and the steps taken to deal with the competing demands of external and internal validity...
  35. ncbi Internet-based self-help for depression: randomised controlled trial
    Gerhard Andersson
    Department of Behavioural Sciences, Linkoping University, SE 581 83 Linkoping, Sweden
    Br J Psychiatry 187:456-61. 2005
    ..Many individuals with depression use the internet for discussion of symptoms and to share their experience...
  36. ncbi A systematic review of adherence with medications for diabetes
    Joyce A Cramer
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes Care 27:1218-24. 2004
    ..The purpose of this study was to determine the extent to which patients omit doses of medications prescribed for diabetes...
  37. ncbi Methods for evaluation of medication adherence and persistence using automated databases
    Susan E Andrade
    Meyers Primary Care Institute, University of Massachusetts Medical School, Fallon Foundation, Fallon Community Health Plan, Worcester, MA 01605, USA
    Pharmacoepidemiol Drug Saf 15:565-74; discussion 575-7. 2006
    ..Our aim was to perform a systematic review of the methods currently being used to assess adherence and persistence in pharmacoepidemiological and pharmacoeconomic studies using automated databases...
  38. pmc Universal definition of loss to follow-up in HIV treatment programs: a statistical analysis of 111 facilities in Africa, Asia, and Latin America
    Benjamin H Chi
    University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Med 8:e1001111. 2011
    ..We analyzed data from health facilities across Africa, Asia, and Latin America to empirically determine a standard LTFU definition...
  39. ncbi Adherence as a determinant of effectiveness of internet cognitive behavioural therapy for anxiety and depressive disorders
    Zita Hilvert-Bruce
    Clinical Research Unit for Anxiety and Depression, School of Psychiatry, University of New South Wales at St Vincent s Hospital, Sydney, Australia
    Behav Res Ther 50:463-8. 2012
    ..It is concluded that improved adherence is an important determinant of effectiveness...
  40. pmc Barriers to sustaining antiretroviral treatment in Kisesa, Tanzania: a follow-up study to understand attrition from the antiretroviral program
    Maria Roura
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, University of London, Mwanza, Tanzania
    AIDS Patient Care STDS 23:203-10. 2009
    ..Effectiveness and sustainability of ART roll-out could be strengthened by strategic intervention at different levels, with particular attention to community-level factors such as social networks' influence and support...
  41. pmc Randomized controlled trial of a personalized cellular phone reminder system to enhance adherence to antiretroviral therapy
    Helene Hardy
    Center for HIV AIDS Care and Research, Boston University Medical Center, Massachusetts, USA
    AIDS Patient Care STDS 25:153-61. 2011
    ..A larger and longer prospective study is needed to confirm these findings and to better understand optimal reminder messages and user fatigue...
  42. ncbi Sexual behavior of HIV discordant couples after HIV counseling and testing
    Susan Allen
    Department of Epidemiology and International Health, School of Public Health, University of Alabama in Birmingham, 35294, USA
    AIDS 17:733-40. 2003
    ..Biological markers were used to assess the validity of self-report...
  43. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  44. ncbi Improving adherence and effectiveness of computerised cognitive behavioural therapy without support for depression: a qualitative study on patient experiences
    S A H Gerhards
    Department of Clinical Psychological Science, Faculty of Psychology, Maastricht University, The Netherlands
    J Affect Disord 129:117-25. 2011
    ..Several studies have evaluated the efficacy and effectiveness of computerized cognitive behavioural therapy (CCBT) for depression, but research on the patient perspective is limited...
  45. pmc Loss to follow-up of adults in public HIV care systems in central Mozambique: identifying obstacles to treatment
    Mark A Micek
    Department of Global Health, University of Washington, Seattle, WA 09195, USA
    J Acquir Immune Defic Syndr 52:397-405. 2009
    ..Access to antiretroviral treatment (ART) has expanded dramatically in resource-limited settings. Evaluating loss to follow-up from HIV testing through post-ART care can help identify obstacles to care...
  46. ncbi Interventions to enhance patient adherence to medication prescriptions: scientific review
    Heather P McDonald
    Health Research Methodology Program, McMaster University School of Graduate Studies, Hamilton, Ontario, Canada
    JAMA 288:2868-79. 2002
    ..Low adherence with prescribed treatments is ubiquitous and undermines treatment benefits...
  47. ncbi Interventions to enhance medication adherence in chronic medical conditions: a systematic review
    Sunil Kripalani
    Division of General Medicine, Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    Arch Intern Med 167:540-50. 2007
    ..Approximately 20% to 50% of patients are not adherent to medical therapy. This review was performed to summarize, categorize, and estimate the effect size (ES) of interventions to improve medication adherence in chronic medical conditions...
  48. ncbi Social support and patient adherence to medical treatment: a meta-analysis
    M Robin Dimatteo
    Department of Psychology, University of California, Riverside, CA 92521, USA
    Health Psychol 23:207-18. 2004
    ..Marital status and living with another person (for adults) increase adherence modestly. A research agenda is recommended to further examine mediators of the relationship between social support and health...
  49. pmc The "ART" of linkage: pre-treatment loss to care after HIV diagnosis at two PEPFAR sites in Durban, South Africa
    Elena Losina
    Division of General Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e9538. 2010
    ..Our objective was to determine PTLC in newly identified HIV-infected individuals in South Africa...
  50. pmc Timing of initiation of antiretroviral drugs during tuberculosis therapy
    Salim S Abdool Karim
    Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa
    N Engl J Med 362:697-706. 2010
    ..The optimal timing for the initiation of antiretroviral therapy in relation to tuberculosis therapy remains controversial...
  51. ncbi Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research
    M Robin Dimatteo
    Department of Psychology, University of California, Riverside, CA 92521, USA
    Med Care 42:200-9. 2004
    ..The literature on patient adherence to treatment includes hundreds of empirical studies. A comprehensive examination of the findings requires the organization and quantification that is possible with meta-analysis...
  52. ncbi Patient compliance with paper and electronic diaries
    Arthur A Stone
    Department of Psychiatry and Behavioral Science, Stony Brook University, NY 11794, USA
    Control Clin Trials 24:182-99. 2003
    ..The findings call into question the use of paper diaries and suggest that electronic diaries with compliance-enhancing features are a more effective way of collecting diary information...
  53. ncbi The concordance of self-report with other measures of medication adherence: a summary of the literature
    Mathew C Garber
    Social and Administrative Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109 1065, USA
    Med Care 42:649-52. 2004
    ....
  54. pmc Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease
    Mark J Atkinson
    Worldwide Outcomes Research, La Jolla Laboratories, Pfizer Inc, 10777 Science Center Drive B 95, San Diego, CA 92121 1111, USA
    Health Qual Life Outcomes 2:12. 2004
    ..The objective of this study was to develop and psychometrically evaluate a general measure of patients' satisfaction with medication, the Treatment Satisfaction Questionnaire for Medication (TSQM)...
  55. ncbi Happy ending: a randomized controlled trial of a digital multi-media smoking cessation intervention
    Håvar Brendryen
    Department of Psychology, University of Oslo, Norway
    Addiction 103:478-84; discussion 485-6. 2008
    ..To assess the long-term efficacy of a fully automated digital multi-media smoking cessation intervention...
  56. pmc Effectiveness of a web-based intervention for problem drinkers and reasons for dropout: randomized controlled trial
    Marloes G Postel
    Nijmegen Institute for Scientist Practitioners in Addiction, Nijmegen, Netherlands
    J Med Internet Res 12:e68. 2010
    ..Online self-help interventions for problem drinkers show promising results, but the effectiveness of online therapy with active involvement of a therapist via the Internet only has not been examined...
  57. pmc Internet-based CBT for depression with and without telephone tracking in a national helpline: randomised controlled trial
    Louise Farrer
    Centre for Mental Health Research, The Australian National University, Canberra, Australian Capital Territory, Australia
    PLoS ONE 6:e28099. 2011
    ..Telephone helplines are frequently and repeatedly used by individuals with chronic mental health problems and web interventions may be an effective tool for reducing depression in this population...
  58. ncbi Association between adherence to antiretroviral therapy and human immunodeficiency virus drug resistance
    Ajay K Sethi
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Clin Infect Dis 37:1112-8. 2003
    ..Clinicians and patients must set high adherence goals to avoid the development of resistance...
  59. pmc Effectiveness of exercise-referral schemes to promote physical activity in adults: systematic review
    Nefyn H Williams
    Department of Primary Care and Public Health School of Medicine, Cardiff University, North Wales Clinical School, Wrecsam
    Br J Gen Pract 57:979-86. 2007
    ..Despite the health benefits of physical activity, most adults do not take the recommended amount of exercise...
  60. pmc Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load. A meta-analytic review of randomized controlled trials
    Jane M Simoni
    Department of Psychology, University of Washington, Seattle, Washington 98195 1525, USA
    J Acquir Immune Defic Syndr 43:S23-35. 2006
    ....
  61. ncbi A randomized controlled intervention trial to relieve and prevent neck/shoulder pain
    Lars L Andersen
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Med Sci Sports Exerc 40:983-90. 2008
    ..The objective of this study is to investigate the effect of three different workplace interventions on long-term compliance, muscle strength gains, and neck/shoulder pain in office workers...
  62. ncbi Technological adjuncts to increase adherence to therapy: a review
    Bonnie A Clough
    Griffith Health Institute, Griffith University, Brisbane, Queensland, Australia
    Clin Psychol Rev 31:697-710. 2011
    ..Adjuncts reviewed included appointment reminders, exercises and monitoring delivered by mobile phone, and exercises and data collection delivered by computer. Limitations and directions for future research were addressed and discussed...
  63. pmc Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators
    Edward J Mills
    Centre for International Health and Human Rights Studies, Toronto, Ontario, Canada
    PLoS Med 3:e438. 2006
    ..We systematically reviewed the literature to determine patient-reported barriers and facilitators to adhering to antiretroviral therapy...
  64. ncbi A systematic review of pediatric adherence to antiretroviral therapy in low- and middle-income countries
    Rachel C Vreeman
    Children s Health Services Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pediatr Infect Dis J 27:686-91. 2008
    ..Sustaining antiretroviral therapy (ART) adherence requires accurate, consistent monitoring, a particular challenge for low-income countries. The optimal strategy to measure pediatric adherence remains unclear...
  65. ncbi Text4Diet: a randomized controlled study using text messaging for weight loss behaviors
    Jennifer R Shapiro
    Santech, Inc, San Diego, CA 92121, USA
    Prev Med 55:412-7. 2012
    ..Text-messaging shows promise as a health intervention. This randomized controlled trial evaluated a daily text-messaging weight loss intervention...
  66. ncbi Adherence to antiretroviral therapy in children attending Mulago Hospital, Kampala
    Nicolette Nabukeera-Barungi
    Department of Paediatrics and Child Health, Faculty of Medicine, Makerere University, Kampala, Uganda
    Ann Trop Paediatr 27:123-31. 2007
    ..Non-adherence reduces the effectiveness of antiretroviral therapy in children attending the paediatric HIV/AIDS clinic at Mulago Hospital, Kampala...
  67. ncbi Adherence with statin therapy in elderly patients with and without acute coronary syndromes
    Cynthia A Jackevicius
    Department of Health Policy, Management, and Evaluation, Pharmacy Department and Women s Health Program, University Health Network Toronto General Hospital, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    JAMA 288:462-7. 2002
    ..Research prior to these trials of older lipid-lowering agents demonstrated low levels of 1-year adherence...
  68. pmc Barriers to accessing highly active antiretroviral therapy by HIV-positive women attending an antenatal clinic in a regional hospital in western Uganda
    Putu Duff
    School of Public Health, University of Alberta, Canada
    J Int AIDS Soc 13:37. 2010
    ....
  69. ncbi Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder
    D Robinson
    Department of Psychiatry, Hillside Hospital, Long Island Jewish Medical Center, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 56:241-7. 1999
    ..We examined relapse after response to a first episode of schizophrenia or schizoaffective disorder...
  70. pmc CBT for depression: a pilot RCT comparing mobile phone vs. computer
    Sarah Watts
    Clinical Research Unit for Anxiety and Depression, School of Psychiatry, University of New South Wales at St Vincent s Hospital, 394 404 Victoria Street, Darlinghurst, NSW, Australia
    BMC Psychiatry 13:49. 2013
    ..The aim was to establish whether a previously validated computerized program (The Sadness Program) remained efficacious when delivered via a mobile application...
  71. ncbi Effect of medication dosing frequency on adherence in chronic diseases
    Sameer D Saini
    Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Am J Manag Care 15:e22-33. 2009
    ..To systematically review available data on the effect of daily medication dosing frequency on medication adherence in chronic disease states, as assessed by precise medication event monitoring systems (MEMS)...
  72. ncbi Older people's recruitment, sustained participation, and adherence to falls prevention interventions in institutional settings: a supplement to the Cochrane systematic review
    Samuel R Nyman
    School of Health and Social Care, University of Reading, Berkshire, UK
    Age Ageing 40:430-6. 2011
    ..randomised controlled trials (RCTs) of falls prevention conducted in institutional settings have recently been systematically reviewed...
  73. pmc Utilization patterns and user characteristics of an ad libitum Internet weight loss program
    Martin Binks
    Binks Behavioral Health PLLC, 2801 Canter Drive, Hillsborough, NC 27278, USA
    J Med Internet Res 12:e9. 2010
    ..There is a paucity of research examining utilization patterns of online weight loss programs, particularly in the rapidly expanding direct-to-consumer arena...
  74. ncbi Effectiveness of antiretroviral therapy among HIV-infected children in sub-Saharan Africa
    Catherine G Sutcliffe
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Lancet Infect Dis 8:477-89. 2008
    ....
  75. ncbi Retention in care: a challenge to survival with HIV infection
    Thomas P Giordano
    Baylor College of Medicine, Houston, Texas, USA
    Clin Infect Dis 44:1493-9. 2007
    ..Patients with human immunodeficiency virus (HIV) infection need lifelong medical care, but many do not remain in care. The effect of poor retention in care on survival is not known, and we sought to quantify that relationship...
  76. pmc Viremia and drug resistance among HIV-1 patients on antiretroviral treatment: a cross-sectional study in Soweto, South Africa
    Ziad El-Khatib
    Division of Global Health IHCAR, Karolinska Institutet, Stockholm, Sweden
    AIDS 24:1679-87. 2010
    ..We assessed risk factors for viremia and drug resistance among long-term recipients of antiretroviral therapy (ART) in South Africa...
  77. ncbi Barriers and facilitators to patients' adherence to antiretroviral treatment in Zambia: a qualitative study
    Nawa Sanjobo
    Copperbelt University
    SAHARA J 5:136-43. 2008
    ..Further research is needed to study interactions between patients and their health care providers. Our findings can inform interventions to improve adherence to ART...
  78. pmc Mamekhaya: a pilot study combining a cognitive-behavioral intervention and mentor mothers with PMTCT services in South Africa
    Donna Futterman
    Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    AIDS Care 22:1093-100. 2010
    ....
  79. ncbi The consistency of adherence to antiretroviral therapy predicts biologic outcomes for human immunodeficiency virus-infected persons in clinical trials
    Sharon Mannheimer
    Harlem Hospital and Columbia University, New York, NY, USA
    Clin Infect Dis 34:1115-21. 2002
    ..001). Nonwhite race was associated with poorer adherence (P<.001), and older age was associated with better adherence (P<.001)...
  80. ncbi Adherence to antiretroviral therapy & its determinants amongst HIV patients in India
    A Sarna
    Horizons Population Council, New Delhi, India
    Indian J Med Res 127:28-36. 2008
    ..There is limited information available from India on adherence to ART and its predictors. We carried out this study to examine adherence levels and to explore the factors associated with adherence among PLHA receiving ART in India...
  81. ncbi Mindfulness-based cognitive therapy to prevent relapse in recurrent depression
    Willem Kuyken
    Mood Disorders Centre, University of Exeter, Exeter, Devon, UK
    J Consult Clin Psychol 76:966-78. 2008
    ..Rates of ADM usage in the MBCT group was significantly reduced, and 46 patients (75%) completely discontinued their ADM. For patients treated with ADM, MBCT may provide an alternative approach for relapse prevention...
  82. pmc Weight loss during the intensive intervention phase of the weight-loss maintenance trial
    Jack F Hollis
    Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon 97227, USA
    Am J Prev Med 35:118-26. 2008
    ..This paper describes methods and results for the initial 6-month weight-loss program (Phase I)...
  83. ncbi Adherence to a six-dose regimen of artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Uganda
    Carole Fogg
    Epicentre, Paris, France
    Am J Trop Med Hyg 71:525-30. 2004
    ..The high adherence to artemether-lumefantrine found in our study suggest that this drug is likely to be very effective in Mbarara provided that patients receive clear dosage explanations...
  84. ncbi Directly observed therapy and tuberculosis: how can a systematic review of qualitative research contribute to improving services? A qualitative meta-synthesis
    Jane Noyes
    Cochrane Qualitative Research Methods Group University of Wales, Bangor, UK
    J Adv Nurs 57:227-43. 2007
    ..This paper reports the findings from a qualitative meta-synthesis concerning people with, or at risk of, tuberculosis, service providers and policymakers and their experiences and perceptions of tuberculosis and treatment...
  85. pmc Adherence to anti-tuberculosis treatment among pulmonary tuberculosis patients: a qualitative and quantitative study
    Weiguo Xu
    Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, PR China
    BMC Health Serv Res 9:169. 2009
    ..Efforts to improve treatment outcomes require better understanding of adherence as a complex behavioral issue and of the particular barriers to and facilitators of patient adherence...
  86. pmc Predictors of adherence to antiretroviral therapy among HIV-infected persons: a prospective study in Southwest Ethiopia
    Alemayehu Amberbir
    Butajira Birth Cohort Study, School of Public Health, Addis Ababa University, P O Box 80596, Addis Ababa, Ethiopia
    BMC Public Health 8:265. 2008
    ..The present study was undertaken to investigate the rate and predictors of adherence to antiretroviral therapy among HIV-infected persons in southwest Ethiopia...
  87. ncbi Treatment supporter to improve adherence to antiretroviral therapy in HIV-infected South African adults. A qualitative study
    Jean B Nachega
    Department of International Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21215, USA
    J Acquir Immune Defic Syndr 43:S127-33. 2006
    ..In addition, our results suggest that interventions tailored to treatment supporter characteristics and relationship factors may be effective in influencing patients' antiretroviral therapy adherence...
  88. pmc Patient retention and adherence to antiretrovirals in a large antiretroviral therapy program in Nigeria: a longitudinal analysis for risk factors
    Man Charurat
    Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e10584. 2010
    ..We used pharmacy refill records to evaluate risk factors for loss to follow-up (LTFU) and non-adherence to ART in a large treatment cohort in Nigeria...
  89. ncbi Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa
    J B Nachega
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 20:1053-6. 2004
    ..Strategies to maximize adherence in this setting should emphasize ready access to affordable and simple ART regimens, as well as HIV education programs to help increase awareness and decrease disease stigmatization...
  90. ncbi The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
    Michael A Kass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 120:701-13; discussion 829-30. 2002
    ..There is no consensus on the efficacy of medical treatment in delaying or preventing the onset of POAG in individuals with elevated IOP. Therefore, we designed a randomized clinical trial, the Ocular Hypertension Treatment Study...
  91. ncbi Correlates and predictors of adherence to highly active antiretroviral therapy: overview of published literature
    Adriana Ammassari
    Clinica delle Malattie Infettive, Universita Cattolica del S Cuore, Roma, Italy
    J Acquir Immune Defic Syndr 31:S123-7. 2002
    ..These limitations concern the measurement of adherence, the assessment of correlates and predictors of adherence, the study population, and the study design...
  92. ncbi The role of patient-physician trust in moderating medication nonadherence due to cost pressures
    John D Piette
    Center for Practice Management and Outcomes Research, Veterans Affairs Ann Arbor Health Care System, Ann Arbor, MI 48113 0170, USA
    Arch Intern Med 165:1749-55. 2005
    ..We examined the extent to which patients' trust in their physicians may moderate the impact of economic constraints and other risk factors for cost-related adherence problems...
  93. ncbi Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV infection
    A Ammassari
    Clinica delle Malattie Infettive, Universita Cattolica del S Cuore, Roma, Italy
    J Acquir Immune Defic Syndr 28:445-9. 2001
    ..To identify variables predictive of nonadherence to highly active antiretroviral therapy (HAART) and to assess whether self-reported symptoms or medication side effects are related to adherence...
  94. ncbi Efficacy of antiretroviral therapy adherence interventions: a research synthesis of trials, 1996 to 2004
    K Rivet Amico
    Center for Health HIV Intervention and Prevention, University of Connecticut, 2006 Hillside Road, Storrs, CT 06269 1248, USA
    J Acquir Immune Defic Syndr 41:285-97. 2006
    ..To conduct a quantitative review of published trials of antiretroviral therapy (ART) adherence interventions...
  95. ncbi Highly active antiretroviral therapies among HIV-1-infected children in Abidjan, Côte d'Ivoire
    Patricia Fassinou
    Pediatric Service, Centre Hospitalier of Yopougon, the Children s Programme Yopougon, France
    AIDS 18:1905-13. 2004
    ..To describe the effect of highly active antiretroviral therapy (HAART) in HIV-1-infected African children...
  96. ncbi Adherence to highly active antiretroviral therapy assessed by pharmacy claims predicts survival in HIV-infected South African adults
    Jean B Nachega
    Department of International Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 43:78-84. 2006
    ..42-7.72, for CD4+ T-cell count<or=50 cells/microL vs >200 cells/microL). Pharmacy-based records may be a simple and effective population-level tool for monitoring adherence as HAART programs in Africa are scaled up...
  97. pmc Self-report measures of antiretroviral therapy adherence: A review with recommendations for HIV research and clinical management
    Jane M Simoni
    Department of Psychology, University of Washington, Seattle, Washington, 98195 1525, Box 351525, USA
    AIDS Behav 10:227-45. 2006
    ..We conclude that even brief self-report measures of antiretroviral adherence can be robust, and recommend items and strategies for HIV research and clinical management...
  98. ncbi Objective adherence monitoring in multiple sclerosis: initial validation and association with self-report
    Jared M Bruce
    Department of Psychology, University of Missouri Kansas City, Kansas City, KS 64110, USA
    Mult Scler 16:112-20. 2010
    ..In contrast, studies employing only self-report may underestimate poor adherence. Larger scale studies that employ prospective objective methods are necessary to gain a better understanding of adherence patterns in multiple sclerosis...
  99. ncbi Physicians encouraging colorectal screening: a randomized controlled trial of enhanced office and patient management on compliance with colorectal cancer screening
    Bruce S Ling
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Arch Intern Med 169:47-55. 2009
    ..Colorectal cancer screening is underused. Our objective was to evaluate methods for promoting colorectal cancer screening in primary care practice...
  100. ncbi Doubts, denial and divine intervention: understanding delayed attendance and poor retention rates at a HIV treatment programme in rural Tanzania
    Alison Wringe
    Centre for Population Studies, London School of Hygiene and Tropical Medicine, London, UK
    AIDS Care 21:632-7. 2009
    ..Decentralisation of HIV services to rural communities should be considered as a priority to redress the balance between perceived barriers to, and benefits of accessing HIV treatment programmes...
  101. ncbi Toward universal access to HIV counseling and testing and antiretroviral treatment in Ethiopia: looking beyond HIV testing and ART initiation
    Yibeltal Assefa
    Medical Services Directorate, Ministry of Health, Addis Ababa, Ethiopia
    AIDS Patient Care STDS 24:521-5. 2010
    ..In conclusion, in spite of the rapid scale-up of HCT and ART services in Ethiopia, linkage and retention were not adequate. Therefore, strategies should be developed and implemented to improve linkage and retention...

Research Grants82

  1. Modulation of host immune defense by Pneumocystis beta-glucans
    EVA MARIA CARMONA PORQUERA; Fiscal Year: 2013
    ..the duration of therapy, fear of secondary effects from the preventive drugs, drug allergies and patient compliance have all contributed to the failure of adequate prophylactic treatments...
  2. Effects of spinal cord injury on vagal afferents from the rat bladder and colon.
    April N Herrity; Fiscal Year: 2013
    ..this area, but current urological treatment options for patients are often difficult to sustain and have low patient compliance 33...
  3. Modifiers of hepcidin expression as new therapies for iron overload
    PAULA GOODMAN FRAENKEL; Fiscal Year: 2013
    ..phlebotomy (hemochromatosis) or chelation therapy (thalassemia), both of which are associated with poor patient compliance because of inconvenience and significant side effects...
  4. Validation of a Novel NF-kB Inhibitor in Inflammatory Bowel Disease
    Anthony Blikslager; Fiscal Year: 2013
    ..This would be an important advancement to minimize toxicity, increase patient compliance, and improve quality of life...
  5. Nanomedicine and NeuroAIDS
    Howard E Gendelman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Drug toxicities, patient compliance and limited penetrance into viral reservoirs (notably the central nervous system (CNS), gut and lymphatic organs) have diminished long-term antiretroviral therapy (..
  6. Novel Phosphate Binder: Effects on Hyperphosphatemia, Vascular Calcification & Bo
    DEANNA J contact NELSON; Fiscal Year: 2010
    ..bind phosphorus effectively, all current forms of phosphate binder therapy are associated with very poor patient compliance due to a host of problems, including side effects that run the gamut of poor taste, halitosis, gastric ..
  7. Hepatic Lipase and HCV Infection
    Tianyi Wang; Fiscal Year: 2010
    ..However, severe side effects are associated with this treatment, leading to poor patient compliance. For these reasons, it is crucial to develop effective vaccine and alternative therapies, a goal that cannot ..
  8. Rocker Shoes for Natural Immobilization of the Ankle during Single Limb Support
    Andrew H Hansen; Fiscal Year: 2012
    ..Walking casts and boots are also highly noticeable interventions that may negatively affect patient compliance. Recent work has shown that rocker shoes can be manufactured that lead to little or no motion at the ankle ..
  9. Delivery of Polyphenols in Gum for Treatment of Gingivitis
    Craig S Miller; Fiscal Year: 2013
    ..To address the unmet need for safe, cost-effective anti-gingivitis product/technology that promotes high patient compliance and could be incorporated into daily use, we have developed a novel, direct compression chewing gum ..
  10. Optimal Prevention and Control of Periodontal Disease: The Periodontal Pocket Irr
    Thomas E Van Dyke; Fiscal Year: 2011
    ..The overwhelming challenge for any periodontal therapy remains dependent on patient compliance to both regular professional and home care...
  11. Development of Transdermal Films for the the Delivery of HIV Therapeutics
    Anthony Sang Won Ham; Fiscal Year: 2010
    ..transdermal films delivery has many advantages over conventional administration such as improved patient compliance in long-term therapy, bypassing first-pass metabolism, sustained drug delivery, avoiding drug peak and ..
  12. Treating cutaneous leishmaniasis by radio-frequency induced heat (RFH) therapy
    Abhay R Satoskar; Fiscal Year: 2012
    ..Current treatment of CL involves 20 injections of pentavalent antimonial drugs which are toxic and have poor patient compliance. The goal of this proposal is to plan a Phase III open label multicenter clinical trial to compare long-term ..
  13. A Diarylheptanoid Scaffold to Treat Taopathies
    Chad A Dickey; Fiscal Year: 2013
    ..that would be suitable for once-daily, oral administration for the treatment of tauopathies, to increase patient compliance and penetration...
  14. Characterization of the Plasma Proteome in Mouse Models of Colon Cancer
    Kenneth E Hung; Fiscal Year: 2010
    ..However, this is an invasive screening procedure limited by available endoscopy resources and patient compliance. Clearly, a robust non-invasive assay is necessary...
  15. Development of novel therapeutics for a neglected tropical disease leishmaniasis
    ABHAY R contact SATOSKAR; Fiscal Year: 2010
    ..Unfortunately these drugs are toxic and have poor patient compliance because many of them require systemic administration for periods ranging from 3-5 wks, and the emergence of ..
  16. Validation and development of trypanosomal phosphodiesterase inhibitors for treat
    Michael P Pollastri; Fiscal Year: 2013
    ..All of these limitations contribute to lower rates of patient compliance, reducing the likelihood of successful treatments...
  17. Hit to Lead Optimization of Small Molecule Therapeutics for Muscular Dystrophy
    Bradley L Hodges; Fiscal Year: 2010
    ..not respond to Ataluren or exon skipping, [5] intervention with orally available compounds should facilitate patient compliance, and lastly [6] small molecules typically have a uncomplicated development path...
  18. Regulation of Intestinal Bile Acid Transport
    Waddah A Alrefai; Fiscal Year: 2013
    ..Although, bile acid sequestrants are clinically proven to lower cholesterol, poor patient compliance necessitates the development of better therapeutic modalities to directly inhibit bile acid absorption...
  19. Protease Operated Depot for Delivery of GLP-1
    Ashutosh Chilkoti; Fiscal Year: 2013
    ..formulations of GLP-1 analogs and other peptide drugs are hence needed to improve drug efficacy and increase patient compliance. Motivated by this rationale, the overall objective of this proposal is to develop a novel biomaterials ..
  20. Engineering a Supplemental Phenylalanine Metabolic Pathway to Prevent mPKU
    Stephen K Hunter; Fiscal Year: 2011
    ..Some treated children still suffer mild cognitive defects. Main inhibitors of patient compliance include the foul taste, expense, and restrictiveness of the diet...
  21. Use of Electronic Protocols to improve provider and client adherence
    MARC D MITCHELL; Fiscal Year: 2010
    ..and Specific Challenge Topic 01-TW-102 Improving health through ICT/mobile technologies: enhancing patient compliance. The Priority topic is implementation research on the use of ICT to adopt and integrate evidence based ..
  22. Maintenance of Skeletal Integrity in Frail Elders
    Susan L Greenspan; Fiscal Year: 2013
    ..The intravenous therapy omits concerns regarding poor oral absorption or patient compliance. Participants will reside in the long term care settings associated with the Division of Geriatric Medicine, ..
  23. Glucose monitoring using polarized light
    Gerard L Cote; Fiscal Year: 2010
    ..Thus a noninvasive device such as the one proposed here would serve to facilitate better patient compliance for monitoring blood glucose...
  24. Novel Therapy and Mechanisms in Glaucoma
    Tonia S Rex; Fiscal Year: 2013
    ..The need for daily treatment can lead to poor patient compliance. We offer an alternative IOP-independent neuroprotective therapy, a modified form of erythropoietin (EPO)...
  25. A Phase II Pivotal Trial to Evaluate the Safety and Efficacy of Notrogen Mustard
    Stuart R Lessin; Fiscal Year: 2010
    ..to the heavy Aquaphor(r) (AP) vehicle which can be difficult to apply to the skin and can compromise patient compliance. A multi-center, randomized, observer-blind trial has been initiated to test the safety and efficacy of a ..
  26. Eliciting protective mechanisms against alcoholism
    Emanuel Rubin; Fiscal Year: 2010
    ..has two main drawbacks that have reduced its use;marked toxicity due to nonspecific action and poor patient compliance with daily intake...
  27. MicroRNA-directed modulation of intraocular pressure
    Benjamin R tenOever; Fiscal Year: 2013
    ..have limitations: they are disruptive, non-specific, do not restore tissue function, and are dependent on patient compliance for daily administration...
  28. pH Sensitive Complex Hydrogels for Protein Drug Release
    Nicholas A Peppas; Fiscal Year: 2013
    ..oral delivery system for protein drugs could lead to the development of new therapeutics with increased patient compliance and efficacy...
  29. The Role of Apathy in Glycemic Control
    Cyrus V Desouza; Fiscal Year: 2011
    ..Thus, apathy influences all stages of self-care. Apathy could also influence patient compliance to diabetes medications. Together this could result in poor control of diabetes and increased complications...
  30. Long-Acting Mucus-Penetrating Steroid Particles for Treatment of Eye Inflammation
    Hongming Chen; Fiscal Year: 2011
    ..Such a regimen greatly reduces patient compliance and increases the risk of adverse effects...
  31. Brain-targeted nanomedicine via buccal administration
    Hu Yang; Fiscal Year: 2010
    ..The ease of buccal drug administration will reduce treatment cost and societal burden, increase patient compliance as well as improve the quality of the overall treatment...
  32. Enhancing Intestinal &Brain Uptake of Anti-AIDS Drugs
    Patrick J Sinko; Fiscal Year: 2013
    ..research will develop novel anti-HIV therapeutics that will dramatically increase potency resulting in reduced doses, less frequent administration, reduced side effects, higher patient compliance rates and better therapeutic outcomes.
  33. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..differences of two or more drugs, drug-drug interactions, overlapping toxicities, cost of multiple drugs and patient compliance are important facets of combination chemotherapy failure...
  34. Sensor-Enabled Elder Social Support Platform
    MARTIN LEWIS GRISS; Fiscal Year: 2010
    ..g., weight, blood pressure) is error-prone and often incomplete due to poor patient compliance, even with customized, context-aware reminders...
  35. Expanding the Clinical Utility of Ultrasound-Assisted Transdermal Drug Delivery
    ROBERT SAMUEL LANGER; Fiscal Year: 2013
    ..circumventing issues related to absorption in the gastrointestinal tract, liver metabolism, and poor patient compliance. The proposed research aims to design a more effective ultrasound-assisted skin treatment regimen in order ..
  36. Novel Method for the Ocular Iontophoretic Delivery of Avastin and Lucentis
    William I Higuchi; Fiscal Year: 2010
    ..to the posterior segment of the eye: * A safe, noninvasive ocular drug delivery method, thereby improving patient compliance. * A system operated by nurses, paraprofessionals, or even patient themselves, making anti- VEGF therapy ..
  37. Formulation of Fenretinide Nanoparticles for Enhanced Bioavailability
    LEVON BOSTANIAN; Fiscal Year: 2013
    ..Lowering the drug dose will also reduce the incidence of adverse side effects and enhance patient compliance. The proposed project will help the principal investigator develop his skills in nanotechnology and the ..
  38. Development of a Practical Non-contact ECG Sensor for Arrhythmia Diagnosis
    Yu M Chi; Fiscal Year: 2012
    ..Issues relating to patient compliance and patient comfort make long-term ECG monitoring problematic, despite the simple and inexpensive nature of ..
  39. Natural Product-Inspired Method for Enhancing HIV Protease Inhibitors
    Jason E Gestwicki; Fiscal Year: 2013
    ..However, patient compliance with HAART is often variable due to treatment- related complications...
  40. Controlling Blood Pressure in Treatment Resistant Hypertension: A Pilot Study
    Marilyn Laken; Fiscal Year: 2012
    ..In clinical trials, where patient compliance is confirmed and BP meds are systematically titrated to attain control, ~20% of patients have TRH, which ..
  41. Therapeutic Intermittent Compression Socket
    TODD RICHARD FARRELL; Fiscal Year: 2010
    ..Increasing perfusion of the limb will both limit ulcer formation and promote ulcer healing. Patient compliance has been shown to be important to successful outcomes with IC therapy...
  42. Healthy Ideas Exchange
    CHIHHUNG JASON WANG; Fiscal Year: 2011
    DESCRIPTION (Provided by the applicant) Abstract: Becker and Maiman wrote ""patient compliance has become the best documented, but least understood, health behavior...
  43. Decision Aid for Cigarette Smokers Undergoing Surgery
    David O Warner; Fiscal Year: 2012
    ..Potential benefits of using decision aids, beyond maximizing patient autonomy, include increased patient compliance with choices, and hopefully, improved health outcomes...
  44. Ocular Drug Delivery Devices for Improved Postoperative Cataract Care
    Buddy D Ratner; Fiscal Year: 2010
    ..been made in the lenses and the procedure, significant issues remain - cost of the surgery and post-op care, patient compliance with post-surgical care, infection, secondary cataracts and post-surgical inflammation...
  45. Cell-based Gene Therapy for Multiple Sclerosis
    KATHERINE LOUIE; Fiscal Year: 2010
    ..that Anergix is developing for the clinic promises to reduce side effects, reduce the burden of more frequent treatments, and thereby improve patient compliance, leading to better disease management over the lifetime of the patient.
  46. Purine biosynthesis as a therapeutic target for Helicobacter pylori infection
    Joanna B Goldberg; Fiscal Year: 2013
    ..In addition to problems with patient compliance, resistance to commonly used antibiotics is becoming an important problem...
  47. A Cardiovascular Risk Reduction Learning Community in DARTNet
    Karl Hammermeister; Fiscal Year: 2010
    ..2) Other factors within the control of care providers (relatively mutable factors, such as drug doses, patient compliance, etc.), and 3) Relatively immutable factors beyond the control of care providers (e.g...
  48. Oral transmucosal drug delivery system for naltrexone for alcohol dependence trea
    HOCK TAN; Fiscal Year: 2009
    ..The former suffers from low bioavailability, poor patient compliance, and significant side effects...
  49. In Vivo Detection of Flat Colorectal Neoplasms with CT Colonography
    JANNE JOHANNES NAPPI; Fiscal Year: 2010
    ..by CTC followed by optional therapeutic OC could be used to provide adequate screening capacity and maximize patient compliance in large-scale colorectal examinations...
  50. Understanding Racial Disparities in Surgical Outcomes
    Jeffrey H Silber; Fiscal Year: 2012
    ..is that it reflects precisely what the surgical and anesthesia team have done, and is not confounded by patient compliance or preferences, as some other measures of process and outcome may be...
  51. Prevention of HIV Acquisition by Long-acting Antiretroviral PrEP
    J VICTOR GARCIA-MARTINEZ; Fiscal Year: 2013
    ..This approach offers major benefits including: (a) the ability to mitigate poor patient compliance with daily systemic PrEP dosing;(b) the potential for a reduced reliance on frequently used HIV therapeutic ..
  52. Conjugation of anticancer drugs
    Swati Nagar; Fiscal Year: 2010
    Colorectal cancer is a preventable yet highly prevalent disease worldwide. Poor patient compliance with screening procedures increases the mortality due to colorectal cancer...
  53. Delivery and Adjuvantation of Nicotine Vaccine by Laser Illumination
    Xinyuan Chen; Fiscal Year: 2013
    ..The novel immunization is also expected to improve patient compliance by elimination of needle injection and induce an early-onset and long-lasting immune response...
  54. A Six-Month, RCT of Probuphine Safety and Efficacy in Opioid Addiction
    Katherine L Beebe; Fiscal Year: 2010
    ..First, patient compliance is low due to the need for frequent dosing, the nature of addictive behavior, and the highly unstable ..
  55. Gyrase B Inhibitors for Mycobacterium Tuberculosis
    Peter B Madrid; Fiscal Year: 2013
    ..The development of a shorter, more effective treatment regimen will increase patient compliance and thereby slow down the emergence of drug resistance and protect vulnerable populations worldwide.
  56. Glycopeptide Fusions to Increase Serum Half-life of Therapeutic Proteins
    ROBERT HEINRIKSON; Fiscal Year: 2010
    ..This means that doses must be administered more often, impacting both patient compliance and cost of treatment...
  57. Electronic system for wireless monitoring of patient medication adherence
    MARK DOUGLAS BURROWS; Fiscal Year: 2012
    ..by applicant): Our objective is to provide patients and physicians with an effective new tool to increase patient compliance (aka adherence) to prescription drug regimens...
  58. Saliva Analyzer for Diagnosing SRD Patient Drug Use
    Stuart Farquharson; Fiscal Year: 2012
    ..with the identification and quantitation abilities of GC-MS so that health care personnel can assess SRD patient compliance in outpatient settings...
  59. Transcriptional Blockades of HIV-1
    Carlos F Barbas; Fiscal Year: 2010
    ..the face of HIV-1 disease, viral resistance, toxicity, side-effects of the drug cocktail, cost issues, and patient compliance are problematic for a significant percentage of the affected population We propose to develop a powerful new ..
  60. WiFi-enabled hand-portable real-time force sensor to objectively assess strength
    DAVID GRANDIN; Fiscal Year: 2013
    ..e., able to test the full rnge of motion). It would also be helpful for therapists to track patient compliance (exercises by reps, sets, resistance, and timing) between therapy sessions...
  61. BIOMEDICAL (APPLIED/EXPLORATORY)
    JUDITH GWATHMEY; Fiscal Year: 2009
    ..reduce patient iron overload, eliminate the need for pump delivery, reduce treatment cost, and increase patient compliance. Phase II will finalize the formulation in preparation for clinical studies...
  62. Oral transmucosal drug delivery system for naltrexone
    HOCK SENG TAN; Fiscal Year: 2013
    ..The former suffers from low bioavailability, poor patient compliance, and significant side effects...
  63. Novel Rinse to Treat Oral Candidiasis in Cancer Patients
    Bakul Bhatt; Fiscal Year: 2007
    ..Its side effects include an altered sense of taste, nausea, and an upset stomach. Once again, patient compliance with the prescribed drug regimen can be an issue not only because of the side effects but also because the ..
  64. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2001
    ..threatening situations, such as postmenopausal osteoporosis, parenteral administration will lead to poor patient compliance and thus restricted utility...
  65. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2003
    ..threatening situations, such as postmenopausal osteoporosis, parenteral administration will lead to poor patient compliance and thus restricted utility...
  66. ORAL CONTROLLED-RELEASE DELIVERY SYSTEMS
    H Rawls; Fiscal Year: 1991
    ..low level presence of a therapeutic agent while minimizing the need for professional involvement and patient compliance. Toward this goal the initial objective is to demonstrate the feasibility of developing a controlled-release ..
  67. Long Acting Beta Interferon for Treating Multiple Sclerosis - Phase II Continuing
    George Cox; Fiscal Year: 2009
    ..per patient, reduce toxicity, reduce immunogenicity and incidence of neutralizing antibodies, improve patient compliance and quality of life and result in considerable cost savings to patients and healthcare providers...
  68. Developing an inactivated whole cell H. pylori vaccine
    GARY NABORS; Fiscal Year: 2006
    ..ubiquitous gastric pathogen Helicobacter pylori, and drug therapy for the infection is complicated by poor patient compliance, the high cost of treatment, and ineffectiveness against drug resistant strains...
  69. Vidarabine Prodrugs as Anti-Pox Virus Agents
    John Hilfinger; Fiscal Year: 2007
    ..of highly effective antiviral agents and reduce undesirable properties such as drug toxicity, poor patient compliance, and high costs associated with current therapy...
  70. SIMPLIFIED POPULATION SCREENING FOR ADULT HYPOTHYROIDISM
    Edwin Naylor; Fiscal Year: 2000
    ..to monitor patients during therapy, providing greater cost effectiveness, comparable accuracy and greater patient compliance than found with traditional methods...
  71. DIABETIC FOOT ULCER DEVICE
    PAUL BUREK; Fiscal Year: 2000
    ..Total contact casts (TCC) off-weight the wound while allowing for ambulation and healing without strict patient compliance. TCC's facilitate healing in up to 90% of cases...
  72. REGULATION OF GLANDULAR MUCOUS CELL SECRETION
    DAVID CULP; Fiscal Year: 2001
    ..in a regulated manner at a higher and more effective dose, but with reduced side effects and increased patient compliance. It is, therefore, imperative to understand how secretory cell receptors are regulated by exposure to ..
  73. Protein Stabilization in Ionic Liquids
    Gloria Elliott; Fiscal Year: 2009
    ..b>Patient compliance decreases as the complexity of administration increases, consequently liquid formulation of parenterals is ..
  74. URINALYSIS FOR PATIENT COMPLIANCE TO CAM THERAPY
    Rama Ramanujam; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): URINALYSIS FOR PATIENT COMPLIANCE TO CAM THERAPY: In recent years, with increasing dissatisfaction with modern medicines coupled with a desire for healthy living, there has been a ..
  75. Novel Anti-Obesity Drugs Targeting Fat Processing Pathway
    Henry Pelish; Fiscal Year: 2009
    ..While providing a critical proof-of-concept in humans, Orlistat suffers from low patient compliance because the unprocessed fats cause gastrointestinal side effects such as fecal urgency and oily spotting...
  76. A Novel Implant-based Approach for Treating Retrognathic Hyperdivergent Patients
    Peter Buschang; Fiscal Year: 2007
    ..simple treatment approach uses mini-screw implants (MSI) to intrude the posterior teeth, it requires minimal patient compliance, and it is expected to produce a large treatment effect...
  77. Nanosphere-Antibiotic Corneal Contact Lens Delivery System
    CHARLES LEAHY; Fiscal Year: 2009
    ..The sustained delivery of ciprofloxacin precludes the use of topical antibiotic drops, resulting in improved patient compliance, convenience, and subsequent efficacy...
  78. Improving Absorption and Targeting of Antiviral Drugs
    John Hilfinger; Fiscal Year: 2009
    ..development of more effective antiviral agents and reduce undesirable outcomes such as drug toxicity, poor patient compliance, and high costs...
  79. Genetic Reconstitution for Phenylketonuria
    Savio Woo; Fiscal Year: 2006
    ..by dietary restriction, the treatment suffers from the need of life-long patient management and poor patient compliance. Discontinuation of dietary restriction during pregnancy in female PKU patients has also caused various ..
  80. Mitochondrial dysfunction in HAART: Point of care tests
    Michael F Marusich; Fiscal Year: 2010
    ..complications from mitochondrial toxicities that can be life-threatening, and limit effectiveness and patient compliance. Adverse metabolic effects are now managed by adept clinicians who monitor patients closely for clinical ..
  81. Diabetic Foot Ulcer Healing by Load Relieving Dressings
    Joseph Loomis; Fiscal Year: 2006
    ..it mechanically off-loads the wound and, since it cannot be removed by the patient, does so without need for patient compliance. Despite its significant superiority over "usual care" in terms of efficacy, acceptance of the TCC by ..
  82. Autonomous Treatment of Opioid Abuse
    Roger J Narayan; Fiscal Year: 2010
    ..to intramuscular or sublingual formulations for treatment of opioid dependence because it (a) increases patient compliance, (b) minimizes diversion of the buprenorphine for illicit use, (c) reduces the frequency of medical ..