smoking

Summary

Summary: Inhaling and exhaling the smoke of tobacco or something similar to tobacco.

Top Publications

  1. doi General and abdominal adiposity and risk of death in Europe
    T Pischon
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    N Engl J Med 359:2105-20. 2008
  2. pmc Tobacco industry control of menthol in cigarettes and targeting of adolescents and young adults
    Jennifer M Kreslake
    Tobacco Control Research Program, Division of Public Health Practice, Harvard School of Public Health, 401 Park Dr, Boston, MA 02215, USA harvard edu
    Am J Public Health 98:1685-92. 2008
  3. doi The menthol smoker: tobacco industry research on consumer sensory perception of menthol cigarettes and its role in smoking behavior
    Jennifer M Kreslake
    Harvard School of Public Health, Division of Public Health Practice Boston, MA 02215, USA
    Nicotine Tob Res 10:705-15. 2008
  4. pmc Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior
    Thorgeir E Thorgeirsson
    1 deCODE genetics, Reykjavik, Iceland 2 Center for Biomolecular Science and Engineering, Jack Baskin School of Engineering, University of California, Santa Cruz, California, USA
    Nat Genet 42:448-53. 2010
  5. ncbi Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
  6. pmc Projections of global mortality and burden of disease from 2002 to 2030
    Colin D Mathers
    Evidence and Information for Policy Cluster, World Health Organization, Geneva, Switzerland
    PLoS Med 3:e442. 2006
  7. pmc Mortality in relation to smoking: 50 years' observations on male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:1519. 2004
  8. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
  9. doi Genetic variations in the TGFβ signaling pathway, smoking and risk of colorectal cancer in a Chinese population
    Rong Zhong
    Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Carcinogenesis 34:936-42. 2013
  10. ncbi Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis
    Carole Willi
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    JAMA 298:2654-64. 2007

Detail Information

Publications373 found, 100 shown here

  1. doi General and abdominal adiposity and risk of death in Europe
    T Pischon
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    N Engl J Med 359:2105-20. 2008
    ....
  2. pmc Tobacco industry control of menthol in cigarettes and targeting of adolescents and young adults
    Jennifer M Kreslake
    Tobacco Control Research Program, Division of Public Health Practice, Harvard School of Public Health, 401 Park Dr, Boston, MA 02215, USA harvard edu
    Am J Public Health 98:1685-92. 2008
    ..We examined whether tobacco manufacturers manipulate the menthol content of cigarettes in an effort to target adolescents and young adults...
  3. doi The menthol smoker: tobacco industry research on consumer sensory perception of menthol cigarettes and its role in smoking behavior
    Jennifer M Kreslake
    Harvard School of Public Health, Division of Public Health Practice Boston, MA 02215, USA
    Nicotine Tob Res 10:705-15. 2008
    ..sensory benefits, and smokers of menthol cigarettes commonly differ from nonmenthol smokers in markers of smoking behavior and addiction...
  4. pmc Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior
    Thorgeir E Thorgeirsson
    1 deCODE genetics, Reykjavik, Iceland 2 Center for Biomolecular Science and Engineering, Jack Baskin School of Engineering, University of California, Santa Cruz, California, USA
    Nat Genet 42:448-53. 2010
    b>Smoking is a common risk factor for many diseases...
  5. ncbi Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
    ..Therefore, the effect of such factors on risk of coronary heart disease in most regions of the world is unknown...
  6. pmc Projections of global mortality and burden of disease from 2002 to 2030
    Colin D Mathers
    Evidence and Information for Policy Cluster, World Health Organization, Geneva, Switzerland
    PLoS Med 3:e442. 2006
    ..This paper describes the methods, assumptions, input data, and results...
  7. pmc Mortality in relation to smoking: 50 years' observations on male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:1519. 2004
    To compare the hazards of cigarette smoking in men who formed their habits at different periods, and the extent of the reduction in risk when cigarette smoking is stopped at different ages.
  8. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
    ....
  9. doi Genetic variations in the TGFβ signaling pathway, smoking and risk of colorectal cancer in a Chinese population
    Rong Zhong
    Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Carcinogenesis 34:936-42. 2013
    ..10 candidate genes involved in the TGFβ signaling pathway and several environmental factors including sex, age, smoking and drinking were examined by random forest (RF) to capture the potential gene-gene and gene-environment ..
  10. ncbi Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis
    Carole Willi
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    JAMA 298:2654-64. 2007
    Observational studies have suggested an association between active smoking and the incidence of type 2 diabetes.
  11. doi Priority actions for the non-communicable disease crisis
    Robert Beaglehole
    University of Auckland, Auckland, New Zealand
    Lancet 377:1438-47. 2011
    ..If widely adopted, these interventions will achieve the global goal of reducing NCD death rates by 2% per year, averting tens of millions of premature deaths in this decade...
  12. pmc C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Stephen Kaptoge
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:132-40. 2010
    ..We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances...
  13. ncbi Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
    C Arden Pope
    Brigham Young University, 130 FOB, Provo, UT 84602 2363, USA
    Circulation 109:71-7. 2004
    ..Associations with specific cardiopulmonary diseases might be useful in exploring potential mechanistic pathways linking exposure and mortality...
  14. pmc A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
    Thorgeir E Thorgeirsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:638-42. 2008
    b>Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year...
  15. pmc Tobacco smoking leads to extensive genome-wide changes in DNA methylation
    Sonja Zeilinger
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 8:e63812. 2013
    Environmental factors such as tobacco smoking may have long-lasting effects on DNA methylation patterns, which might lead to changes in gene expression and in a broader context to the development or progression of various diseases...
  16. ncbi International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study
    A Sonia Buist
    Oregon Health and Sciences University, Portland, OR 97239, USA
    Lancet 370:741-50. 2007
    ..We aimed to measure the prevalence of COPD and its risk factors and investigate variation across countries by age, sex, and smoking status.
  17. pmc The collective dynamics of smoking in a large social network
    Nicholas A Christakis
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 358:2249-58. 2008
    The prevalence of smoking has decreased substantially in the United States over the past 30 years...
  18. ncbi Global burden of COPD: risk factors, prevalence, and future trends
    David M Mannino
    Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY 40536, USA
    Lancet 370:765-73. 2007
    ..It is a global health issue, with cigarette smoking being an important risk factor universally; other factors, such as exposure to indoor and outdoor air pollution, ..
  19. pmc Meta-analysis and imputation refines the association of 15q25 with smoking quantity
    Jason Z Liu
    Department of Statistics, University of Oxford, Oxford, UK
    Nat Genet 42:436-40. 2010
    b>Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits...
  20. ncbi Smoking and mental illness: A population-based prevalence study
    K Lasser
    Department of Medicine, Cambridge Hospital, Macht Bldg, 1493 Cambridge St, Cambridge, MA 02139, USA
    JAMA 284:2606-10. 2000
    ..mental illness, such as those who are institutionalized or seen in mental health clinics, have reported rates of smoking to be higher than in persons without mental illness...
  21. ncbi Complement factor H variant increases the risk of age-related macular degeneration
    Jonathan L Haines
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 308:419-21. 2005
    ..45 and 5.57. This common variant likely explains approximately 43% of AMD in older adults...
  22. ncbi Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths
    Sarah Lewington
    CTSU, University of Oxford, Oxford OX3 7LF, UK
    Lancet 370:1829-39. 2007
    ..This meta-analysis combined prospective studies of vascular mortality that recorded both blood pressure and total cholesterol at baseline, to determine the joint relevance of these two risk factors...
  23. ncbi Obesity, cigarette smoking, and telomere length in women
    A M Valdes
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Lancet 366:662-4. 2005
    Obesity and smoking are important risk factors for many age-related diseases...
  24. ncbi European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by r
    Ian Graham
    Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur Heart J 28:2375-414. 2007
  25. doi Electronic cigarettes for smoking cessation: a randomised controlled trial
    Christopher Bullen
    National Institute for Health Innovation, School of Population Health, The University of Auckland, Auckland, New Zealand Electronic address
    Lancet 382:1629-37. 2013
    ..We investigated whether e-cigarettes are more effective than nicotine patches at helping smokers to quit...
  26. ncbi The pathophysiology of cigarette smoking and cardiovascular disease: an update
    John A Ambrose
    Comprehensive Cardiovascular Center, Saint Vincent Catholic Medical Centers of New York, New York, New York 10011, USA
    J Am Coll Cardiol 43:1731-7. 2004
    Cigarette smoking (CS) continues to be a major health hazard, and it contributes significantly to cardiovascular morbidity and mortality...
  27. pmc Phasing-out tobacco: proposal to deny access to tobacco for those born from 2000
    Deborah Khoo
    National Cancer Centre Singapore, Department of Surgical Oncology, 11 Hospital Drive, Singapore 169610, Singapore
    Tob Control 19:355-60. 2010
    ..In conjunction, a survey that we have conducted in Singapore indicates strong public support (even among current smokers) for the proposal...
  28. doi Current status of cadmium as an environmental health problem
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Toxicol Appl Pharmacol 238:201-8. 2009
    ..Food is the main source of cadmium intake in the non-smoking population...
  29. ncbi Assessment of validity of self-reported smoking status
    Suzy L Wong
    Health Analysis Division, Statistics Canada, Ottawa, Ontario, K1A 0T6
    Health Rep 23:47-53. 2012
    Cigarette smoking is associated with adverse health effects, including cancer, respiratory illness, heart disease and stroke. National data on smoking prevalence often rely on self-reports...
  30. pmc 50-year trends in smoking-related mortality in the United States
    Michael J Thun
    Department of Epidemiology, American Cancer Society, Atlanta, GA 30303 1002, USA
    N Engl J Med 368:351-64. 2013
    The disease risks from cigarette smoking increased in the United States over most of the 20th century, first among male smokers and later among female smokers...
  31. pmc A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci
    Sreekumar G Pillai
    Genetics Division, GlaxoSmithKline Research and Development, Research Triangle Park, NC, USA
    PLoS Genet 5:e1000421. 2009
    ..association study (GWAS) in a homogenous case-control cohort from Bergen, Norway (823 COPD cases and 810 smoking controls) and evaluated the top 100 single nucleotide polymorphisms (SNPs) in the family-based International COPD ..
  32. pmc Lung cancer susceptibility locus at 5p15.33
    James D McKay
    International Agency for Research on Cancer IARC, Lyon, France
    Nat Genet 40:1404-6. 2008
    ..016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology...
  33. ncbi Consequences of smoking for body weight, body fat distribution, and insulin resistance
    Arnaud Chiolero
    Institute of Social and Preventive Medicine IUMSP, University of Lausanne, 17 rue du Bugnon, 1005 Lausanne, Switzerland
    Am J Clin Nutr 87:801-9. 2008
    Our aim was to critically evaluate the relations among smoking, body weight, body fat distribution, and insulin resistance as reported in the literature...
  34. pmc Tobacco-smoking-related differential DNA methylation: 27K discovery and replication
    Lutz P Breitling
    Division C070 Clinical Epidemiology and Aging Research, German Cancer Research Center, D 69120 Heidelberg, Germany
    Am J Hum Genet 88:450-7. 2011
    Tobacco smoking is responsible for substantial morbidity and mortality worldwide, in particular through cardiovascular, pulmonary, and malignant pathology...
  35. pmc Characterisation of COPD heterogeneity in the ECLIPSE cohort
    Alvar Agusti
    Thorax Institute, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Spain
    Respir Res 11:122. 2010
    ..Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE)...
  36. pmc Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
    Tirumalai Rangasamy
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Invest 114:1248-59. 2004
    ..The responsiveness of the Nrf2 pathway may act as a major determinant of susceptibility to tobacco smoke-induced emphysema by upregulating antioxidant defenses and decreasing lung inflammation and alveolar cell apoptosis...
  37. pmc The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors
    Goodarz Danaei
    Harvard School of Public Health, Boston, MA, USA
    PLoS Med 6:e1000058. 2009
    ..and blood pressure; overweight-obesity; high dietary trans fatty acids and salt; low dietary polyunsaturated fatty acids, omega-3 fatty acids (seafood), and fruits and vegetables; physical inactivity; alcohol use; and tobacco smoking.
  38. pmc Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study
    Riccardo Polosa
    Centro per la Prevenzione e Cura del Tabagismo CPCT, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Universita di Catania, Catania, Italy
    BMC Public Health 11:786. 2011
    Cigarette smoking is a tough addiction to break. Therefore, improved approaches to smoking cessation are necessary...
  39. pmc Complement factor H polymorphism in age-related macular degeneration
    Robert J Klein
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 308:385-9. 2005
    ..This polymorphism is in a region of CFH that binds heparin and C-reactive protein. The CFH gene is located on chromosome 1 in a region repeatedly linked to AMD in family-based studies...
  40. ncbi European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by represent
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:S1-113. 2007
  41. doi Smoking prevalence and cigarette consumption in 187 countries, 1980-2012
    Marie Ng
    Institute for Health Metrics and Evaluation, University of Washington, Seattle
    JAMA 311:183-92. 2014
    ..Tobacco is a leading global disease risk factor. Understanding national trends in prevalence and consumption is critical for prioritizing action and evaluating tobacco control progress...
  42. doi 21st-century hazards of smoking and benefits of cessation in the United States
    Prabhat Jha
    Center for Global Health Research, Toronto, ON M5C 1N8, Canada
    N Engl J Med 368:341-50. 2013
    Extrapolation from studies in the 1980s suggests that smoking causes 25% of deaths among women and men 35 to 69 years of age in the United States...
  43. doi Tobacco use in 3 billion individuals from 16 countries: an analysis of nationally representative cross-sectional household surveys
    Gary A Giovino
    Department of Community Health and Health Behavior, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY 14214 8028, USA alo edu
    Lancet 380:668-79. 2012
    ..We assess these patterns through analysis of data from the Global Adult Tobacco Survey (GATS)...
  44. pmc Reduction in cadmium exposure in the United States population, 1988-2008: the contribution of declining smoking rates
    Maria Tellez-Plaza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room W7513D, Baltimore, MD 21205 USA
    Environ Health Perspect 120:204-9. 2012
    ..S. adults. However, trends in urine cadmium, a marker of cumulative cadmium exposure, have not been evaluated...
  45. ncbi Prevalence of conventional risk factors in patients with coronary heart disease
    Umesh N Khot
    Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    JAMA 290:898-904. 2003
    ..more than 50% of patients with coronary heart disease (CHD) lack any of the conventional risk factors (cigarette smoking, diabetes, hyperlipidemia, and hypertension)...
  46. pmc Trends in socioeconomic inequalities in smoking prevalence, consumption, initiation, and cessation between 2001 and 2008 in the Netherlands. Findings from a national population survey
    Gera E Nagelhout
    STIVORO Dutch Expert Centre on Tobacco Control, PO Box 16070, 2500 BB, The Hague, The Netherlands
    BMC Public Health 12:303. 2012
    Widening of socioeconomic status (SES) inequalities in smoking prevalence has occurred in several Western countries from the mid 1970's onwards...
  47. doi Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy
    Jean Francois Etter
    Institute of Social and Preventive Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Addiction 106:2017-28. 2011
    ..To assess the profile, utilization patterns, satisfaction and perceived effects among users of electronic cigarettes ('e-cigarettes')...
  48. pmc Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
    PLoS ONE 3:e1651. 2008
    Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the precise molecular alterations induced by smoking in lung that develop into cancer and impact survival have remained obscure.
  49. doi The case for the plain packaging of tobacco products
    Becky Freeman
    School of Public Health, University of Sydney, NSW, Australia
    Addiction 103:580-90. 2008
    ..It critiques legal objections raised by the industry about plain packaging violating laws and international trade agreements...
  50. doi A nationally representative case-control study of smoking and death in India
    Prabhat Jha
    Centre for Global Health Research, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    N Engl J Med 358:1137-47. 2008
    The nationwide effects of smoking on mortality in India have not been assessed reliably.
  51. ncbi Measures of abstinence in clinical trials: issues and recommendations
    John R Hughes
    Department of Psychiatry, Psychology and Family Practice University of Vermont, Burlington 05401 1419, USA
    Nicotine Tob Res 5:13-25. 2003
    ..the Society for Research on Nicotine and Tobacco reviewed the literature on abstinence measures used in trials of smoking cessation interventions. We recommend that trials report multiple measures of abstinence...
  52. doi Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study
    Bartolome R Celli
    Tufts University School of Medicine, Pulmonary and Critical Care Division, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
    Am J Respir Crit Care Med 178:332-8. 2008
    ..Chronic obstructive pulmonary disease (COPD) is characterized by an accelerated decline in lung function. No drug has been shown conclusively to reduce this decline...
  53. ncbi Epidemiology of menthol cigarette use
    Gary A Giovino
    Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Nicotine Tob Res 6:S67-81. 2004
    ..and correlates of menthol cigarette use can guide the development and implementation of strategies to reduce smoking prevalence and smoking-attributable morbidity and mortality...
  54. doi Mass media campaigns to promote smoking cessation among adults: an integrative review
    Sarah Durkin
    Centre for Behavioural Research in Cancer, Cancer Council Victoria, Carlton, Victoria, Australia
    Tob Control 21:127-38. 2012
    ..This review summarises the impact of mass media campaigns on promoting quitting among adult smokers overall and for subgroups; the influence of campaign intensity and different channels; the effects of different message types...
  55. ncbi Effects of cigarette smoke on the immune system
    Mohan Sopori
    Immunology Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Nat Rev Immunol 2:372-7. 2002
    Although the health risks of tobacco smoking are well documented, there is increasing evidence that smokers have a lower incidence of some inflammatory and neurodegenerative diseases...
  56. ncbi Systemic effects of smoking
    Dilyara G Yanbaeva
    Department of Respiratory Medicine, University Hospital Maastricht Maastricht University, 6202 AZ Maastricht, The Netherlands
    Chest 131:1557-66. 2007
    b>Smoking is one of the major lifestyle factors influencing the health of human beings. Life-long cigarette smokers have a higher prevalence of common diseases such as atherosclerosis and COPD with significant systemic impact...
  57. ncbi Lung cancer in never smokers--a different disease
    Sophie Sun
    Division of Haematology and Oncology and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Rev Cancer 7:778-90. 2007
    Although most lung cancers are a result of smoking, approximately 25% of lung cancer cases worldwide are not attributable to tobacco use, accounting for over 300,000 deaths each year...
  58. ncbi Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study
    Ana Maria B Menezes
    Universidade Federal de Pelotas, Pelotas, Brazil
    Lancet 366:1875-81. 2005
    ..The aim of the PLATINO study, launched in 2002, was to describe the epidemiology of COPD in five major Latin American cities: São Paulo (Brazil), Santiago (Chile), Mexico City (Mexico), Montevideo (Uruguay), and Caracas (Venezuela)...
  59. ncbi Major causes of death among men and women in China
    Jiang He
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    N Engl J Med 353:1124-34. 2005
    ..We studied the major causes of death and modifiable risk factors in a nationally representative cohort of 169,871 men and women 40 years of age and older in China...
  60. pmc Adding social deprivation and family history to cardiovascular risk assessment: the ASSIGN score from the Scottish Heart Health Extended Cohort (SHHEC)
    Mark Woodward
    Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK
    Heart 93:172-6. 2007
    ..To improve equity in cardiovascular disease prevention by developing a cardiovascular risk score including social deprivation and family history...
  61. pmc Online social networks and smoking cessation: a scientific research agenda
    Nathan K Cobb
    Schroeder Institute for Tobacco Research and Policy Studies, American Legacy Foundation, Washington, DC 20036, USA
    J Med Internet Res 13:e119. 2011
    b>Smoking remains one of the most pressing public health problems in the United States and internationally...
  62. doi Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking
    Natalie S Shenker
    Epigenetics Unit, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK
    Hum Mol Genet 22:843-51. 2013
    ..The association was analysed between methylation and smoking status, as well as cancer risk...
  63. ncbi Actual causes of death in the United States, 2000
    Ali H Mokdad
    Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    JAMA 291:1238-45. 2004
    ..Modifiable behavioral risk factors are leading causes of mortality in the United States. Quantifying these will provide insight into the effects of recent trends and the implications of missed prevention opportunities...
  64. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions...
  65. ncbi Risk of tuberculosis from exposure to tobacco smoke: a systematic review and meta-analysis
    Michael N Bates
    School of Public Health, University of California, Berkeley, USA
    Arch Intern Med 167:335-42. 2007
    There is no consensus whether tobacco smoking increases risk of tuberculosis (TB) infection, disease, or mortality. Whether this is so has substantial implications for tobacco and TB control policies.
  66. pmc Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls
    Allan Hackshaw
    CRUK and UCL Trials Centre, University College London, 90 Tottenham Court Road, London, UK
    Hum Reprod Update 17:589-604. 2011
    BACKGROUND ; There is uncertainty over whether maternal smoking is associated with birth defects. We conducted the first ever comprehensive systematic review to establish which specific malformations are associated with smoking...
  67. ncbi Tobacco and tuberculosis: a qualitative systematic review and meta-analysis
    K Slama
    The International Union Against Tuberculosis and Lung Disease, Paris, France
    Int J Tuberc Lung Dis 11:1049-61. 2007
    To assess the strength of evidence in published articles for an association between smoking and passive exposure to tobacco smoke and various manifestations and outcomes of tuberculosis (TB)...
  68. ncbi Tobacco smoke carcinogens and lung cancer
    S S Hecht
    University of Minnesota Cancer Center, Minneapolis 55455, USA
    J Natl Cancer Inst 91:1194-210. 1999
    ..By focusing in this review on several important carcinogens in tobacco smoke, the complexities in understanding tobacco-induced cancer can be reduced, and new approaches for lung cancer prevention can be envisioned...
  69. pmc The 21st century hazards of smoking and benefits of stopping: a prospective study of one million women in the UK
    Kirstin Pirie
    Cancer Epidemiology Unit, University of Oxford, Oxford, UK
    Lancet 381:133-41. 2013
    ..Hence, only in the 21st century can we observe directly the full effects of prolonged smoking, and of prolonged cessation, on mortality among women in the UK.
  70. doi Thirty-five-year trends in cardiovascular risk factors in Finland
    Erkki Vartiainen
    National Institute for Health and Welfare, Helsinki, Finland
    Int J Epidemiol 39:504-18. 2010
    ..From 1972 to 2007, risk factor surveys have been carried out to monitor risk factor trends and assess their contribution to declining mortality in Finland...
  71. doi Lung cancer
    Roy S Herbst
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    N Engl J Med 359:1367-80. 2008
  72. pmc Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype
    Alvar Agusti
    Thorax Institute, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona and Centro de investigación en red de enfermedades respiratorias CIBERES, Barcelona, Spain
    PLoS ONE 7:e37483. 2012
    ..To explore if the persistence of systemic inflammation is associated with poor clinical outcomes in COPD we assessed patients recruited to the well-characterized ECLIPSE cohort (NCT00292552)...
  73. doi Mortality attributable to smoking among HIV-1-infected individuals: a nationwide, population-based cohort study
    Marie Helleberg
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Clin Infect Dis 56:727-34. 2013
    We assessed mortality attributable to smoking among patients with human immunodeficiency virus (HIV).
  74. pmc 'The smoking toolkit study': a national study of smoking and smoking cessation in England
    Jennifer A Fidler
    Cancer Research UK Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, London, UK
    BMC Public Health 11:479. 2011
    Up-to-date data tracking of national smoking patterns and cessation-related behaviour is required to evaluate and inform tobacco control strategies. The Smoking Toolkit Study (STS) was designed for this role...
  75. pmc Combined impact of health behaviours and mortality in men and women: the EPIC-Norfolk prospective population study
    Kay Tee Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    PLoS Med 5:e12. 2008
    ..We aimed to quantify the potential combined impact of four health behaviours on mortality in men and women living in the general community...
  76. pmc EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Comprehensive Cancer Center Head and Neck Cancer Program, Ann Arbor, MI 48109, USA
    J Clin Oncol 26:3128-37. 2008
    ..To prospectively identify markers of response to therapy and outcome in an organ-sparing trial for advanced oropharyngeal cancer...
  77. ncbi Shape of the relapse curve and long-term abstinence among untreated smokers
    John R Hughes
    University of Vermont, Department of Psychiatry, Burlington, VT 05401 1419, USA
    Addiction 99:29-38. 2004
    ..To describe the relapse curve and rate of long-term prolonged abstinence among smokers who try to quit without treatment...
  78. pmc Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations
    I S Patel
    Academic Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, London EC1A 7BE, UK
    Thorax 57:759-64. 2002
    ..Stable COPD patients often have lower airway bacterial colonisation which may be an important stimulus to airway inflammation and thereby modulate exacerbation frequency...
  79. ncbi Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study
    John F Keaney
    Evans Memorial Department of Medicine, Boston University School of Medicine, Whitaker Cardiovascular Institute, 715 Albany St, Rm W507, Boston, MA 02118, USA
    Arterioscler Thromb Vasc Biol 23:434-9. 2003
    ..Thus, it has been difficult to evaluate the relative contribution of each cardiovascular risk factor to systemic oxidative stress and to determine whether such risk factors act independently and are applicable to the general population...
  80. ncbi Menthol pharmacology and its potential impact on cigarette smoking behavior
    Karen Ahijevych
    College of Nursing and College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Nicotine Tob Res 6:S17-28. 2004
    ..Subjective effects of smoothness and less harshness have been identified as reasons for menthol cigarette smoking, but findings have been inconclusive regarding the effect of menthol on carbon monoxide exposure and smoking ..
  81. ncbi Are menthol cigarettes a starter product for youth?
    James C Hersey
    RTI International, Washington, DC 20036, USA
    Nicotine Tob Res 8:403-13. 2006
    ..compared with nonmenthol smokers, controlling for demographic background and the length, frequency, and level of smoking. The study suggests that menthol cigarettes are a starter product that may be associated with smoking uptake by ..
  82. doi Socioeconomic status and smoking: a review
    Rosemary Hiscock
    Tobacco Control Research Group, Department of Health, University of Bath, Bath, United Kingdom
    Ann N Y Acad Sci 1248:107-23. 2012
    b>Smoking prevalence is higher among disadvantaged groups, and disadvantaged smokers may face higher exposure to tobacco's harms...
  83. doi The accuracy of self-reported smoking: a systematic review of the relationship between self-reported and cotinine-assessed smoking status
    Sarah Connor Gorber
    Health Measures Analysis Section, Health Information and Research Division, Statistics Canada, 24th Floor R H Coats Building, 100 Tunney s Pasture Driveway, Ottawa, ON, Canada K1A 0T6
    Nicotine Tob Res 11:12-24. 2009
    b>Smoking is a leading cause of premature mortality and preventable morbidity. Surveillance is most often based on self-reported data, but studies have shown that self-reports tend to underestimate smoking status.
  84. pmc Maternal smoking during pregnancy and offspring trajectories of height and adiposity: comparing maternal and paternal associations
    Laura D Howe
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK
    Int J Epidemiol 41:722-32. 2012
    Maternal smoking during pregnancy is associated with reduced offspring birth length and has been postulated as a risk factor for obesity. Causality for obesity is not established...
  85. doi Electronic cigarettes as a smoking-cessation: tool results from an online survey
    Michael B Siegel
    Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Am J Prev Med 40:472-5. 2011
    ..These devices have generated much publicity among the smoking-cessation community and support from dedicated users; however, little is known about the efficacy of the device ..
  86. ncbi Size at birth and early childhood growth in relation to maternal smoking, parity and infant breast-feeding: longitudinal birth cohort study and analysis
    Ken K L Ong
    Department of Paediatrics, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Pediatr Res 52:863-7. 2002
    ..We examined the relationship between maternal smoking, parity, and breast- or bottle-feeding to size at birth and childhood growth between 0 and 5 y in a large ..
  87. ncbi Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies
    Kaarin J Anstey
    Centre for Mental Health Research, School of Psychology, The Australian National University, Canberra, Australia
    Am J Epidemiol 166:367-78. 2007
    The authors assessed the association of smoking with dementia and cognitive decline in a meta-analysis of 19 prospective studies with at least 12 months of follow-up...
  88. pmc Impact of an electronic cigarette on smoking reduction and cessation in schizophrenic smokers: a prospective 12-month pilot study
    Pasquale Caponnetto
    CTA Villa Chiara Psychiatric Rehabilitation Clinic and Research, Mascalucia, Catania 95030, Italy
    Int J Environ Res Public Health 10:446-61. 2013
    Cigarette smoking is a tough addiction to break. This dependence is the most common dual diagnosis for individuals with schizophrenia...
  89. doi Acute impact of active and passive electronic cigarette smoking on serum cotinine and lung function
    Andreas D Flouris
    FAME Laboratory, Centre for Research and Technology Thessaly, Karies, Trikala, Greece
    Inhal Toxicol 25:91-101. 2013
    ..Electronic cigarettes (e-cigarettes) are becoming increasingly popular yet their effects on health remain unknown...
  90. doi School-based programmes for preventing smoking
    Roger E Thomas
    Department of Family Medicine, Faculty of Medicine, University of Calgary, Calgary, Canada
    Cochrane Database Syst Rev 4:CD001293. 2013
    Helping young people to avoid starting smoking is a widely endorsed public health goal, and schools provide a route to communicate with nearly all young people. School-based interventions have been delivered for close to 40 years.
  91. ncbi Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey
    Nanshan Zhong
    Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical College, 151 Yanjiang Road, Guangzhou, Guangdong 510120, China
    Am J Respir Crit Care Med 176:753-60. 2007
    ..The prevalence of chronic obstructive pulmonary disease (COPD) in China is largely unknown...
  92. doi Effect of an electronic nicotine delivery device (e cigarette) on desire to smoke and withdrawal, user preferences and nicotine delivery: randomised cross-over trial
    C Bullen
    Clinical Trials Research Unit, The University of Auckland, Auckland, New Zealand
    Tob Control 19:98-103. 2010
    ..To measure the short-term effects of an electronic nicotine delivery device ("e cigarette", ENDD) on desire to smoke, withdrawal symptoms, acceptability, pharmacokinetic properties and adverse effects...
  93. doi Can data from primary care medical records be used to monitor national smoking prevalence?
    Lisa Szatkowski
    Division of Primary Care, Queen s Medical Centre, UK Centre for Tobacco Control Studies, University of Nottingham, Derby Road, Nottingham NG7 2UH, UK
    J Epidemiol Community Health 66:791-5. 2012
    Data from primary care records could potentially provide more comprehensive population-level information on smoking prevalence at lower cost and in a more timely fashion than commissioned national surveys...
  94. ncbi Epidemiology of nasopharyngeal carcinoma
    Mimi C Yu
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Semin Cancer Biol 12:421-9. 2002
    ..Other recognized risk factors for NPC are cigarette smoking, and occupational exposure to formaldehyde and wood dust.
  95. doi Ending appreciable tobacco use in a nation: using a sinking lid on supply
    George Thomson
    University of Otago, Wellington, Box 7343, Wellington, New Zealand
    Tob Control 19:431-5. 2010
    ..which in turn would reflect the impact of other interventions to reduce demand and the changing normality of smoking. Higher priced tobacco could result in increased smuggling, theft, illegal sales and short-to-medium-term ..
  96. ncbi Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    Anthony J Alberg
    Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas St, PO Box 250955, Charleston, SC 29425, USA
    Chest 132:29S-55S. 2007
    ..The objective of this study was to summarize the published literature concerning the epidemiology of lung cancer...
  97. pmc Variants in FAM13A are associated with chronic obstructive pulmonary disease
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 42:200-2. 2010
    ..2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83)...
  98. doi Online support for smoking cessation: a systematic review of the literature
    Lion Shahab
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK
    Addiction 104:1792-804. 2009
    To examine the efficacy and acceptability of online, interactive interventions for smoking cessation and to identify treatment effect moderators and mediators.
  99. ncbi Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    Peter M A Calverley
    University Hospital Aintree, Liverpool, United Kingdom
    N Engl J Med 356:775-89. 2007
    ..Long-acting beta-agonists and inhaled corticosteroids are used to treat chronic obstructive pulmonary disease (COPD), but their effect on survival is unknown...
  100. doi Socioeconomic inequalities in health in 22 European countries
    Johan P Mackenbach
    Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 358:2468-81. 2008
    ..Comparisons among countries can help to identify opportunities for the reduction of inequalities in health. We compared the magnitude of inequalities in mortality and self-assessed health among 22 countries in all parts of Europe...

Research Grants90

  1. Assessment of Nicotine Metabolism Among Underserved Pregnant Women from NE SCRIPT
    Donna Parker; Fiscal Year: 2007
    ..Project Summary/Abstract: Smoking during pregnancy is of particular concern because smoking affects not only the health of the woman but also the ..
  2. Bupropion for Smoking Cessation in Postpartum Women
    Nancy Rigotti; Fiscal Year: 2007
    ..to prepare for a future randomized controlled trial testing the efficacy of the antidepressant bupropion for smoking cessation in postpartum women...
  3. Molecular Epidemiology of Smoking & Breast Cancer
    KATHLEEN CONWAY DORSEY; Fiscal Year: 2005
    Despite considerable research, the relationship between cigarette smoking and breast cancer remains controversial...
  4. Folate, Smoking, Race and Cervical Cancer Risk
    Capri Mara Fillmore; Fiscal Year: 2004
    ..assess the interrelationships of these three factors in cervical cancer, by examining the interaction of folate, smoking, and race...
  5. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..Moreover, since smoking and alcohol use are the two most prevalent risk factors associated with HNSCC, field cancerization leads to ..
  6. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..Importantly, periodontal disease is exacerbated by diabetes and smoking, and periodontitis substantially increases the risk of systemic illness such as cardiovascular and renal disease, ..
  7. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..For Aim 1 we will test the importance of multiple factors (poor diet, stage of CLD, smoking, insulin resistance, age and race) as independent predictors of serum antioxidant levels...
  8. Regulation of mural cells during pulmonary capillary formation
    Stephen E McGowan; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE: Although the prevalence of smoking has declined, chronic obstructive pulmonary disease (COPD) and its attendant pathological pulmonary abnormality, ..
  9. The Habenulo-Interpeduncular Pathway and Nicotine
    Christie D Fowler; Fiscal Year: 2013
    ..provide a basis for further identification of novel drug targets with the goal of developing more efficacious smoking cessation therapeutics...
  10. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..The extensive database permits examination of confounding and interaction by relevant variables including smoking, medications, and usual dental care...
  11. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    ..b>Smoking and aging can result in higher amounts of citrullination...
  12. Nanoparticle Coupled Antioxidants for Respiratory Illness in Veterans
    RODNEY JON SCHLOSSER; Fiscal Year: 2013
    ..Nearly half of OEF/OIF Veterans started or re-started smoking during deployment...
  13. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-Lead
    CYNTHIA T MCEVOY; Fiscal Year: 2013
    ..study to determine if vitamin C supplementation (500 mg daily) can decrease the effect of maternal smoking in pregnancy on offspring pulmonary function (VC-SIP)...
  14. Tobacco Control Research Branch Scientific and Technical Services Support
    KOURTNEY MARSHALL; Fiscal Year: 2009
    ..change the tobacco and tobacco smoke constituents; 10) The epidemiologic, clinical or experimental nature of the smoking relationship with specific diseases or conditions...
  15. Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    Arthur Brody; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite improvements in tobacco control, the prevalence of cigarette smoking remains high at 27% among Veterans and 21% among the general U.S. population (~46 million U.S. adults)...
  16. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    ..to the failure of anti-HCV therapy, including obesity, diabetes, alcohol abuse, oxidative stress, cigarette smoking and environmental pollutants...
  17. MOLECULAR MECHANISMS OF COMPLEX MIXTURE TOXICITY
    Alvaro Puga; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Environmental exposure to hexavalent chromium in drinking water and cigarette smoking and occupational exposure in the workplace are often compounded with concomitant exposures to aromatic ..
  18. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..Despite an overall decline in the smoking prevalence in the United States, smoking incidence remains higher in veterans when compared to the same age group ..
  19. Efficacy of Yoga for Treatment-Resistant PTSD
    Bessel Van der Kolk; Fiscal Year: 2010
    ..risk to develop alcoholism, depression, drug abuse, and to make suicide attempts, a 2-4 times greater risk for smoking, a 1.4- 1.6 times greater risk for physical inactivity and obesity, and a 1.6-2...
  20. Expanding Vietnamese Community and Academic Infrastructure for Health Research
    Bang H Nguyen; Fiscal Year: 2010
    ..proposal review panels and submission, and community health forums;2) research topics - to include diet, smoking cessation, hepatitis B, occupational exposure reduction, comparative- and cost-effectiveness of mobile ..
  21. FOLLOW UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY
    Jarmo Virtamo; Fiscal Year: 2010
    ..At entry, medical, dietary, smoking, and occupational data were obtained, along with physical measurements, a chest x-ray, and serum and toenail ..
  22. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..includes a strong genetic component as well as lifestyle factors such as physical inactivity, dietary habits and smoking. While there has been a trend over the last half century showing a general decline in the age-adjusted death ..
  23. Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
    Michelle A Williams; Fiscal Year: 2013
    ..We will use the self-matched case-crossover design to evaluate the acute effects of: 1) maternal smoking and alcohol consumption;2) physical exertion;3) sexual activity;4) abdominal trauma secondary to falls or motor ..
  24. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..of the atherogenic response, with elevated levels of blood cholesterol, high blood pressure, diabetes, and smoking recognized as primary risk factors...
  25. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2012
    ..variation in the regulatory regions that may alter gene expression or are reportedly associated with risk of smoking-related cancers...
  26. ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURY
    Irfan Rahman; Fiscal Year: 2013
    ..key intracellular molecular events in the sirtuin 1 (an anti-aging and anti-inflammatory protein) pathway which will allow us to identify therapeutic targets for COPD-emphysema and other chronic inflammatory diseases linked to smoking.
  27. Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01
    W Michael Foster; Fiscal Year: 2010
    ..Importantly additional observations by us in a healthy cohort of non-smoking human subjects (n=135) demonstrates that a homozygotic genotype for a single nucleotide polymorphism of the ..
  28. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-DCC
    Cynthia D Morris; Fiscal Year: 2013
    ..study to determine if vitamin C supplementation (500 mg daily) can decrease the effect of maternal smoking in pregnancy on offspring pulmonary function (VC-SIP)...
  29. Randomized trial of PEITC as a modifier of NNK metabolism in smokers
    Jian Min Yuan; Fiscal Year: 2012
    ..Cigarette smoking causes approximately 90% of lung cancer...
  30. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..cell responses that may contribute to the persistence of auto-reactive T cells in subjects that have long ceased smoking but continue to have a decline in lung function...
  31. Multivariate CART for survival with dental applications
    Martha E Nunn; Fiscal Year: 2013
    ..time until tooth loss, complete restorative and periodontal records with follow-up, significant medical history, smoking, oral hygiene, special needs, compliance, frequency of dental visits and other parameters that are collected as ..
  32. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2012
    ..prevention;for preventing the first occurrence of bladder cancer in those with risk factors such as cigarette smoking and industrial exposures...
  33. Health Care Disparities in the Pacific Islands Pacific Regional Medical Conferenc
    SAIED SAFABAKHSH; Fiscal Year: 2011
    ..in Need: Treating Tobacco Dependence among Diverse Smokers in the Inpatient Psychiatry Setting Culture, Smoking, Readiness to Quit, and Cessation: Exploring the Role of Discrimination and Ethnic Identity on Tobacco ..
  34. EPIDEMIOLOGY: OXIDATIVE STRESS AND EARLY ATHEROSCLEROSIS
    David Jacobs; Fiscal Year: 2009
    ..relates to inflammation and endothelial dysfunction, interacting with conditions such as adiposity, glycemia and smoking. Such oxidative stress, even in young adulthood, may contribute to long term disease risk long before clinical ..
  35. EPIDEMIOLOGY: OXIDATIVE STRESS AND EARLY ATHEROSCLEROSIS
    David R Jacobs; Fiscal Year: 2013
    ..relates to inflammation and endothelial dysfunction, interacting with conditions such as adiposity, glycemia and smoking. Such oxidative stress, even in young adulthood, may contribute to long term disease risk long before clinical ..
  36. Impact of smoking on immune response and arthritis in humanized mice
    Veena Taneja; Fiscal Year: 2011
    ..Epidemiological studies in humans have suggested smoking as a major environmental risk factor for seropositive RA...
  37. Imaging of Aortic Atherosclerosis and Inflammation in the Metabolic Syndrome
    Warren J Manning; Fiscal Year: 2012
    ..heart disease (CHD) risk factors include age, male gender, family history of premature CHD, hypertension, smoking, diabetes, elevated LDL-C, and low HDL-C...
  38. High Throughput Methods to Measure Disparities in Childhood Exposure to Tobacco
    Sharon E Murphy; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Children are involuntarily exposed to tobacco both in utero through maternal smoking and during childhood from secondhand smoke (SHS)...
  39. RRSS #08: Evaluating Prevalence HPV Infection Among Head and Neck Cancer Patients
    Dennis M Deapen; Fiscal Year: 2009
    ..Patients with HPV-positive HNSCC tend to be younger and free of smoking and drinking history, the majority of them are females...
  40. Validation of a multi-gene test for lung cancer risk
    James C Willey; Fiscal Year: 2010
    Lung cancer is the leading cause of cancer mortality in both men and women in the United States with cigarette smoking being the primary known risk factor and has a low survival rate in part because it typically is at an advanced stage ..
  41. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..US, several states (Idaho, Wyoming, Colorado, New Mexico, and Arizona) exhibit a puzzling disparity between smoking attributable mortality, and the much higher mortality from COPD...
  42. The New England Family Study: Fifty Year Post-Perinatal Follow-Up for Life Course
    ERIC contact LOUCKS; Fiscal Year: 2010
    ..g. intrauterine growth restriction, maternal serum cortisol levels, maternal smoking and socioeconomic adversity) with epigenetic processes (often measured as DNA methylation) that could alter gene ..
  43. Epidemiological Research on Autism in Jamaica
    Mohammad H Rahbar; Fiscal Year: 2010
    ..and controls we will administer a questionnaire to assess the demographic and socioeconomic position, occupation, smoking and drinking status of the parents...
  44. Mediators of Atherosclerosis in South Asians Living in America
    Alka M Kanaya; Fiscal Year: 2013
    ..We found that South Asians had higher socioeconomic attainment, lower smoking and alcohol use, relatively low BMI and waist circumference, and higher hypertension and diabetes prevalence...
  45. The RAGE of COPD
    John R Hoidal; Fiscal Year: 2013
    ..It will impact our ability to prevent or reduce the enormous medical burden caused by cigarette smoking. Nowhere is the need for new approaches with clinical application more important in pulmonary diseases than in ..
  46. Role of Id1 in NSCLC Progression and Metastasis
    Srikumar P Chellappan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-small cell lung carcinoma (NSCLC) is highly correlated with smoking and smokers constitute about 75% of NSCLC patients...
  47. Reducing Preterm Births in Underserved Pregnant Women
    JAMES G CHRISTIAN; Fiscal Year: 2011
    ..woman's unique risks in six modifiable areas associated with increased risks of preterm birth including smoking cessation, poor nutrition, domestic violence, maternal depression and stress, urinary and reproductive tract ..
  48. Resolving the role of nicotine-mediated phosphorylation on pancreatic fibrosis
    Joao A Paulo; Fiscal Year: 2013
    ..Pancreatic stellate cells (PaSC) are key mediators of pancreatic fibrosis. Smoking is an independent risk factor for pancreatic disease...
  49. The Role of Vascular Innervation on Tissue-type Plasminogen Activator Release
    JAMES ANTHONY SHEERIN MULDOWNEY; Fiscal Year: 2013
    ..Physiologic release of t-PA is deleteriously altered by modifiable cardiac risk factors such as smoking, hypertension, hyperlipidemia and obesity...
  50. Lifestyle and Molecular Factors of Bone Health in Breast Cancer Survivors
    Song Yao; Fiscal Year: 2013
    ..with 1) modifiable lifestyle factors such as physical activity, diet, vitamin D and calcium supplement use, smoking, and alcohol consumption;2) germline genetic variations in estrogen and bone metabolism pathways with validation ..
  51. Integrated PTSD and Smoking Treatment
    Mark B Powers; Fiscal Year: 2013
    ..Here, my clinical and research experiences have guided me to focus on smoking cessation...
  52. Web-based Patient-Reported Outcomes (PRO) System for Breast Cancer Survivors
    JOHN CHRISTOPHER WEISS; Fiscal Year: 2010
    ..g., dietician, smoking cessation, exercise program, peer support, etc...
  53. Shared Mechanisms of Valvular and Vascular Calcification
    JOEL DAVID MORRISETT; Fiscal Year: 2012
    ..levels and is particularly associated with age, male gender, high blood pressure, high lipid levels, smoking, type II diabetes, and obesity. Many aspects of CAVD resemble atherosclerosis and vascular calcification...
  54. Cancer induction in the ovary by an environmental pollutant, dibenzo[a,l]pyrene
    Kun Ming Chen; Fiscal Year: 2013
    ..Recent studies have shown that tobacco smoking is associated with cancer of the ovary...
  55. North Lawndale Diabetes Community Action Project
    STEVEN contact WHITMAN; Fiscal Year: 2010
    ..a validated instrument assessing general diet, specific diet, exercise, blood-glucose testing, foot care, and smoking behaviors. It will be administered at baseline and 1-yr anniversary follow-up...
  56. Translational Approaches to Reducing Health Disparities in Lung Disease
    Joe G N Garcia; Fiscal Year: 2012
    ..African Americans are three times more likely to succumb to asthma compared to Caucasians. Despite the lower smoking rates, the incidence, the severity and mortality related to lung cancer are much higher in African Americans...
  57. Statins for Pulmonary and Cardiac Complications of Chronic HIV (The SPARC Trial)
    Stephen R Wisniewski; Fiscal Year: 2013
    ..Our work has demonstrated that a syndrome of "cardiopulmonary dysfunction" exists even in non-smoking or antiretroviral-treated HIV+ individuals and is associated with increased respiratory symptoms as well as with ..
  58. Brain Nicotine Receptor Density &Response to Nicotine Patch
    Arthur Brody; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Even though the health risks and societal costs of cigarette smoking are well-known, roughly 19.8% of American adults continue to smoke...
  59. Extending Sleep in Obese Adults to Promote Weight Loss
    Ann E Rogers; Fiscal Year: 2010
    ..marketing practices, the increased use of central heating and air conditioning, increasing gravid age, decreased smoking rates, and decreased sleep durations...
  60. Epidemiological Research on Autism in Jamaica - Phase II
    Mohammad H Rahbar; Fiscal Year: 2013
    ..and controls we will administer a questionnaire to assess the demographic and socioeconomic position, occupation, smoking and drinking status of the parents...
  61. International Conf on Alzheimer Disease and Related Disorders in the Middle East
    Changiz Geula; Fiscal Year: 2013
    ..the Middle East, a region with unique features valuable for research, including a high rate of consanguinity and smoking, relatively homogenous populations, and high fat diet...
  62. Human Papillomavirus Association with Subsets of Colorectal Cancer
    Polly A Newcomb; Fiscal Year: 2010
    ..the association between colorectal HPV infection and personal characteristics, including: gender, age and smoking status...
  63. Cigarette Smoke-derived Electrophilic Aldehydes and Airway Inflammation
    Albert van Der Vliet; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cigarette smoking remains a major global health burden and is strongly associated with increased childhood respiratory infections and development of chronic lung diseases such as COPD, asthma and ..
  64. Genetic Susceptibility Factors in Porphyria Cutanea Tarda (PCT)
    Karl Anderson; Fiscal Year: 2009
    ..Susceptibility factors include hepatitis C, alcohol use, smoking, iron overload, HIV, estrogens and an inherited partial deficiency of UROD...
  65. Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular Risk
    Sheila Gahagan; Fiscal Year: 2012
    ..Detailed information about family history, smoking, health, and psychosocial functioning will also be collected...
  66. Characterizing Mitochondrial DNA Susceptibility to Breast, Colorectal, and Prosta
    Iona Cheng; Fiscal Year: 2012
    ..grade, ER+/- breast tumors, colon/rectum tumors), environmental factors related to mitochondrial activity (smoking, BMI, fat, carotenoids, vitamin C, vitamin E, iron, lycopene and selenium) and susceptibility loci for breast, ..
  67. INTERNATIONAL GENETIC EPIDEMIOLOGY OF ORAL CLEFTS
    Terri H Beaty; Fiscal Year: 2013
    ..2) To consider models for assessing gene-environment (GxE) interactions with common maternal exposures (maternal smoking, alcohol consumption and vitamin supplementation) by analyzing the entire genome wide SNP array using our GWAS ..
  68. Mediators of Lithium Action in Olfactory Epithelium
    Evaristus A Nwulia; Fiscal Year: 2013
    ..project, we propose to use our successful recruitment approach of BD subjects, to ascertain 40 non-medicated, non-smoking subjects with acute episodes of BD and 20 gender-, age-, and race- matched non-smoking normal controls (CTL) for ..
  69. Development of Pharmacotherapies for Nicotine Addiction
    Frank Carroll; Fiscal Year: 2009
    ..In response to PAR-04-009, we are pleased to submit this application whose overall goal is to find a better smoking cessation drug...
  70. Improving the efficacy of anti-nicotine immunotherapy
    Alexey G Mukhin; Fiscal Year: 2010
    ..long-term goal of this research project is to improve the efficacy of anti-nicotine vaccination/immunotherapy for smoking cessation...
  71. Preventing Postpartum Smoking Relapse: A C-SHIP Based Text Messaging Intervention
    Suzanne M Miller; Fiscal Year: 2010
    ..OBSSR)-101*, Using new technologies to improve or measure adherence, and is entitled "Preventing postpartum smoking relapse: A C-SHIP based Text Messaging intervention...
  72. Using Ecolog. Momentary Assess. To Examine Pain & Smoking In Head & Neck Cancer P
    CHO YAN LAM; Fiscal Year: 2010
    Continued smoking after cancer has been diagnosed is associated with a poor treatment outcome and a low overall survival rate. However, on learning about their cancer diagnosis, many patients who smoke continue to use tobacco...
  73. Clinical Response to Biomarker Documentation of Child Secondhand Smoke Exposure
    ANNE JOSEPH; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Smoking and secondhand smoke (SHS) are responsible for nearly a half-million preventable deaths in the United States every year...
  74. Translational approaches to multilevel models of prenatal exposure to cigarettes
    Vanja Dukic; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Assessing smoking, like assessing and quantifying many other addictive behaviors, often suffers from recall bias, deliberate misreporting and even non-disclosure...
  75. Scripps Florida Product Development Partnership for smoking cessation therapeutic
    Paul J Kenny; Fiscal Year: 2011
    ..It is predicted that ~0.6 billion current smokers worldwide will die from smoking-related illnesses, such as chronic obstructive pulmonary disorder (COPD), lung cancer, and cardiovascular disease...
  76. Development of a Next Generation Vaccine for Smoking Cessation and Relapse Preven
    Grayson B Lipford; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The goal of this project is to develop a superior anti-nicotine vaccine for smoking cessation...
  77. Promoting Oral Health Among Tobacco Users: A Pilot Feasibility Study
    JENNIFER B MC CLURE; Fiscal Year: 2010
    ..data to support the development of an oral health promotion program designed to be integrated into standard smoking cessation treatment offered through state tobacco quitlines...
  78. A Cohort Study of Active and Passive Smoking in Korea
    Jonathan Samet; Fiscal Year: 2003
    Although 50 years of research findings have causally linked active and passive smoking to cancer and other diseases, further epidemiologic research on the risks of tobacco smoking is still needed...
  79. Predictive Smoking Cessation Preclinical Battery
    Daniela Brunner; Fiscal Year: 2012
    ..great advances in both the understanding of the neurobiology of addiction and the development and approval of smoking cessation therapies, a significant need remains for better smoking cessation aids...
  80. The Impact of Smoke-Free Policy on Quitline Utilization and Smoking Outcomes
    ANITA FAY FERNANDER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cigarette smoking produces substantial and staggering health and health-related economic costs to society...
  81. CIGARETTE TAXES AND PRENATAL SMOKING
    Theodore Joyce; Fiscal Year: 2002
    DESCRIPTION: Prenatal smoking is the most important modifiable risk factor for poor pregnancy outcomes in the United States...
  82. Integrated Web and phone smoking cessation counseling
    CHRISTIAN CARTTER; Fiscal Year: 2003
    ..S., especially for health information. Self-help treatments for smoking cessation are effective, are greatly preferred by smokers, and have the potential to reach more individuals than ..
  83. The effect of antismoking parenting practices on adolescent smoking
    Daniel Rodriguez; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Adolescence is a critical period for smoking initiation and progression...
  84. Exploring the Role of Race/Ethnicity & Family Influences to Reduce Youth Smoking
    E MELINDA MELINDA MAHABEE GITTENS; Fiscal Year: 2010
    ..have been indicated as explanatory factors for some of the differences in national trends in adolescent smoking initiation and progression...
  85. Maternal Smoking and the Developing Lung
    Kathleen J Haley; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Despite aggressive public education campaigns, maternal tobacco smoking remains an important public health problem...
  86. Mood Management Phone Counseling in Smoking Cessation
    David Strong; Fiscal Year: 2007
    ..a history of recurrent major depression (MDD) report higher levels of depressive symptoms when presenting for smoking cessation treatment and have poor smoking outcomes relative to other smokers...
  87. Supportive Behaviors to Assist in Smoking Cessation
    Kimber Richter; Fiscal Year: 2005
    Social support is an important but frequently under-examined factor in smoking cessation...
  88. NEUROCOGNITIVE PREDICTORS OF SMOKING CESSATION
    Andrey P Anokhin; Fiscal Year: 2010
    ..The overall goal of the proposed study is to identify neurophysiological and behavioral markers of sensitivity to smoking cessation treatment...
  89. COMBINING SCHEDULED REDUCTION WITH WEIGHT CONTROL
    William Riley; Fiscal Year: 1999
    The overall goal of this project is to develop a self-help smoking cessation with an integrated weight control component...
  90. SMS Turkey: Harnessing the power of TXT messaging to promote smoking cessation
    Michele Ybarra; Fiscal Year: 2010
    b>Smoking has long been recognized as a significant public health concern associated with great morbidity and mortality...