exploratory behavior

Summary

Summary: The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity.

Top Publications

  1. ncbi Risk taking and novelty seeking in adolescence: introduction to part I
    Ann E Kelley
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Ann N Y Acad Sci 1021:27-32. 2004
  2. pmc The ontogeny of anxiety-like behavior in rats from adolescence to adulthood
    Debra A Lynn
    School of Psychology, University of St Andrews, South Street, St Andrews, Fife, UK
    Dev Psychobiol 52:731-9. 2010
  3. ncbi Conjunctive representation of position, direction, and velocity in entorhinal cortex
    Francesca Sargolini
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 312:758-62. 2006
  4. pmc Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
    Dave G Mumby
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, H4B 1R6, Quebec, Canada
    Learn Mem 9:49-57. 2002
  5. ncbi Life-history trade-offs favour the evolution of animal personalities
    Max Wolf
    Theoretical Biology Group, Centre for Ecological and Evolutionary Studies, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    Nature 447:581-4. 2007
  6. ncbi Hippocampal plasticity across multiple days of exposure to novel environments
    Loren M Frank
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 24:7681-9. 2004
  7. ncbi A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field
    E Choleris
    Room 9222D, Department of Psychology, Social Science Center, University of Western Ontario, London, Ontario, Canada N6A 5C2
    Neurosci Biobehav Rev 25:235-60. 2001
  8. ncbi Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
    C Rampon
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, New Jersey 08540 1014, USA
    Nat Neurosci 3:238-44. 2000
  9. ncbi Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors
    U Maskos
    Unité Récepteurs et Cognition, CNRS URA 2182, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nature 436:103-7. 2005
  10. ncbi Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation
    Victor Ramirez-Amaya
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 25:1761-8. 2005

Detail Information

Publications322 found, 100 shown here

  1. ncbi Risk taking and novelty seeking in adolescence: introduction to part I
    Ann E Kelley
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Ann N Y Acad Sci 1021:27-32. 2004
    ..Moreover, the investigation of mammalian animal models of adolescence-such as those examining impulsivity, reward sensitivity, and decision making-may also provide new opportunities for addressing the problem of adolescent vulnerability...
  2. pmc The ontogeny of anxiety-like behavior in rats from adolescence to adulthood
    Debra A Lynn
    School of Psychology, University of St Andrews, South Street, St Andrews, Fife, UK
    Dev Psychobiol 52:731-9. 2010
    ..These results support the hypothesis that adolescent rats have a more pronounced response to stressors than do adults...
  3. ncbi Conjunctive representation of position, direction, and velocity in entorhinal cortex
    Francesca Sargolini
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 312:758-62. 2006
    ..All cell types were modulated by running speed. The conjunction of positional, directional, and translational information in a single MEC cell type may enable grid coordinates to be updated during self-motion-based navigation...
  4. pmc Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
    Dave G Mumby
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, H4B 1R6, Quebec, Canada
    Learn Mem 9:49-57. 2002
    ..The findings indicate that hippocampal damage impairs memory for contextual or spatial aspects of an experience, whereas memory for objects that were part of the same experience are left relatively intact...
  5. ncbi Life-history trade-offs favour the evolution of animal personalities
    Max Wolf
    Theoretical Biology Group, Centre for Ecological and Evolutionary Studies, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    Nature 447:581-4. 2007
    ..Moreover, it explains the common finding that explorative behaviour and risk-related traits like boldness and aggressiveness are common characteristics of animal personalities...
  6. ncbi Hippocampal plasticity across multiple days of exposure to novel environments
    Loren M Frank
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci 24:7681-9. 2004
    ..These results show that the hippocampus can form new spatial representations quickly but that stable hippocampal representations are not sufficient for a place to be treated as familiar...
  7. ncbi A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field
    E Choleris
    Room 9222D, Department of Psychology, Social Science Center, University of Western Ontario, London, Ontario, Canada N6A 5C2
    Neurosci Biobehav Rev 25:235-60. 2001
    ..e. pulsed magnetic field) on anxiety-like behaviors, but also permits the examination of non-specific effects, in particular those on general activity...
  8. ncbi Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
    C Rampon
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, New Jersey 08540 1014, USA
    Nat Neurosci 3:238-44. 2000
    ..Therefore, our data indicate that CA1 NMDA receptor activity is critical in hippocampus-dependent nonspatial memory, but is not essential for experience-induced synaptic structural changes...
  9. ncbi Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors
    U Maskos
    Unité Récepteurs et Cognition, CNRS URA 2182, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nature 436:103-7. 2005
    ..We thus demonstrate the sufficient role of the VTA in both nicotine reinforcement and endogenous cholinergic regulation of cognitive functions...
  10. ncbi Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation
    Victor Ramirez-Amaya
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 25:1761-8. 2005
    ..This is the first demonstration of network-selective translational events consequent to spatial behavior and suggests a role for immediate-early genes in circuit-specific, late-phase synaptic biology...
  11. ncbi Distinct roles of medial and lateral entorhinal cortex in spatial cognition
    Tiffany Van Cauter
    Laboratory of Cognitive Neuroscience, UMR 7291 Aix Marseille University Centre National de la Recherche Scientifique, 13331 Marseille Cedex 3, France
    Cereb Cortex 23:451-9. 2013
    ..The LEC has some influence on both spatial and nonspatial processes, suggesting that the 2 kinds of information interact at the level of the EC...
  12. ncbi Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition
    S L Dix
    School of Psychology, University of Cardiff Wales, Cardiff, UK
    Behav Brain Res 99:191-200. 1999
    ..In the standard condition and the context condition, the first 2 min were found to be the most sensitive period. In the two conditions involving a position change, discrimination was only evident in the first minute...
  13. ncbi Individual housing of mice--impact on behaviour and stress responses
    Saskia S Arndt
    Department of Animals, Science and Society, Division of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, P O Box 80166, 3508 TD Utrecht, The Netherlands
    Physiol Behav 97:385-93. 2009
    ..However, we observed a within-cage order effect on the hormonal stress response (corticosterone) in socially-housed female C57BL/6 mice. No effects of individual housing on behaviour in the mHB were found...
  14. ncbi Effects of chronic fluoxetine in animal models of anxiety and depression
    Stephanie C Dulawa
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 29:1321-30. 2004
    ..In the forced swim test, 10 and 18 mg/kg/day increased swimming and reduced immobility. Here we present several novel effects of chronic, but not subchronic, antidepressant treatment...
  15. pmc An unexpected sequence of events: mismatch detection in the human hippocampus
    Dharshan Kumaran
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    PLoS Biol 4:e424. 2006
    ..The present study also offers broader insights into the nature of essential computations carried out by the hippocampus, which may also underpin its unique contribution to episodic memory...
  16. ncbi Findings from animals concerning when interactions between perirhinal cortex, hippocampus and medial prefrontal cortex are necessary for recognition memory
    E Clea Warburton
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, UK
    Neuropsychologia 48:2262-72. 2010
    ....
  17. ncbi When is the hippocampus involved in recognition memory?
    Gareth R I Barker
    Medical Research Council Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 31:10721-31. 2011
    ..Thus, the hippocampus plays a role in recognition memory when such memory involves remembering that a particular stimulus occurred in a particular place or when the memory contains a temporal or object recency component...
  18. ncbi Performance of different mouse strains in an object recognition task
    Ayhan Sik
    Department of Psychiatry and Neuropsychology, Brain and Behaviour Institute, Maastricht University, 6200 MD Maastricht, The Netherlands
    Behav Brain Res 147:49-54. 2003
    ..The present data show that object memory can be assessed in mice and, in contrast to other memory tasks, appears to be less strain-dependent. The reliability of the discrimination measures is discussed...
  19. pmc Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia
    Christopher J Henry
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 333 W, 10th Ave, Columbus, OH 43210, USA
    J Neuroinflammation 5:15. 2008
    ..The purpose of this study was to determine if minocycline, an anti-inflammatory agent and purported microglial inhibitor, attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia...
  20. pmc Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats
    Melissa J Glenn
    Psychology and Neuroscience, Duke University, Durham, NC, USA
    Brain Res 1237:110-23. 2008
    ....
  21. pmc Hippocampal brain-network coordination during volitional exploratory behavior enhances learning
    Joel L Voss
    Beckman Institute for Advanced Science and Technology, University of Illinois Urbana Champaign, Urbana, Illinois, USA
    Nat Neurosci 14:115-20. 2011
    ..Furthermore, brain structures that are typically seen as passive participants in memory encoding (for example, the hippocampus) are actually part of an active network that controls behavior dynamically as it unfolds...
  22. ncbi Environmental enrichment reverses the effects of maternal separation on stress reactivity
    Darlene D Francis
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 22:7840-3. 2002
    ..We conclude that environmental enrichment leads to a functional reversal of the effects of maternal separation through compensation for, rather than reversal of, the neural effects of early life adversity...
  23. pmc Lateral entorhinal neurons are not spatially selective in cue-rich environments
    D Yoganarasimha
    Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, Texas, USA
    Hippocampus 21:1363-74. 2011
    ..These data strongly support the notion that the MEC and LEC convey fundamentally different types of information to the hippocampus, in terms of their spatial firing characteristics, under various environmental and behavioral conditions...
  24. ncbi Sex differences in the behavioral response to spatial and object novelty in adult C57BL/6 mice
    Karyn M Frick
    Department of Psychology, Yale University, New Haven, Connecticut 06520, USA karyn frick yale edu
    Behav Neurosci 117:1283-91. 2003
    ..Neither sex displayed a preference for the novel object after 7 days. The data suggest that male mice are superior to females at localizing and recognizing objects...
  25. ncbi Double dissociation between the effects of peri-postrhinal cortex and hippocampal lesions on tests of object recognition and spatial memory: heterogeneity of function within the temporal lobe
    Boyer D Winters
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 24:5901-8. 2004
    ..These results provide strong evidence in favor of heterogeneity and independence of function within the temporal lobe...
  26. ncbi Avian personalities: characterization and epigenesis
    Ton G G Groothuis
    Animal Behaviour Group, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Neurosci Biobehav Rev 29:137-50. 2005
    ..These data suggest that variation in selection pressure in time and space and assortative mating are plausible mechanisms accounting for the maintenance of different behavioral profiles within the same population...
  27. ncbi Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex
    Gareth R I Barker
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 27:2948-57. 2007
    ..Importantly, these results provide direct support for the hypothesis that to make discriminations based on associational or recency information, both cortical regions operate within an integrated neural network for recognition memory...
  28. ncbi Exploratory behavior, cortical BDNF expression, and sleep homeostasis
    Reto Huber
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Sleep 30:129-39. 2007
    ..The aim of the study was to determine whether neuronal plasticity underlies the link between waking activities and the SWA response...
  29. pmc Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior
    Francois Frenois
    Integrative Immunology and Behavior Program, University of Illinois at Urbana Champaign, 212 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801, USA
    Psychoneuroendocrinology 32:516-31. 2007
    ....
  30. pmc Social approach in genetically engineered mouse lines relevant to autism
    S S Moy
    Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Genes Brain Behav 8:129-42. 2009
    ..Findings from the fragile X model suggest that the FVB/129 background confers enhanced susceptibility to consequences of Fmr1 mutation on social approach...
  31. pmc General learning ability regulates exploration through its influence on rate of habituation
    Kenneth R Light
    Rutgers University, Department of Psychology, Piscataway, NJ 08854, USA
    Behav Brain Res 223:297-309. 2011
    ..In total, these results indicate that the relationship between exploration and general learning abilities is accounted for by the impact of habituation (itself a form of learning) on behaviors indicative of exploration...
  32. pmc Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: possible anatomical substrates for viscerosensory modulation of exploratory behavior
    Lisa E Goehler
    Department of Psychology, University of Virginia, Charlottesville, VA 22904, USA
    Brain Behav Immun 22:354-66. 2008
    ....
  33. ncbi Characteristics of object location memory in mice: Behavioral and pharmacological studies
    Takeshi Murai
    Pharmacology, Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, 3 Okubo, Tsukuba, Ibaraki 300 2611, Japan
    Physiol Behav 90:116-24. 2007
    ..The object location memory in mice was sensitive to pharmacological manipulation with cholinergic agents and to aging and could be used to identify agents affecting spatial memory...
  34. pmc Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors
    I Inoue
    Department of Molecular Immunology, Kyushu University, Fukuoka, Japan
    Proc Natl Acad Sci U S A 93:13316-20. 1996
    ..In addition, mutant mice significantly reduced exploratory behavior of ambulation and rearings in a new environment...
  35. ncbi Social curiosity and interpersonal perception: a judge x trait interaction
    Freda Marie Hartung
    University of Konstanz, Department of Psychology, Psychological Assessment and Health Psychology, PO Box 47, 78457 Konstanz, Germany
    Pers Soc Psychol Bull 37:796-814. 2011
    ..The results suggest that high socially curious individuals are more accurate in judging visible traits and that this higher accuracy is grounded in a more comprehensive utilization of valid cues...
  36. pmc MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning
    Jacobi I Cunningham
    Laboratory of Neurochemistry, Department of Pharmacology, Boston University School of Medicine, Boston, USA
    Behav Neurosci 123:1076-84. 2009
    ..These results show that prior exposure to MDMA leads to stress-induced impairments in learning behavior that is not otherwise observed with stress alone and appear unrelated to an enhanced depletion of SERT...
  37. ncbi Behavioral profiles and stress-induced corticosteroid secretion in male Wistar rats subjected to short and prolonged periods of maternal separation
    Erika Roman
    Department of Pharmaceutical Biosciences, Division of Pharmacology, Uppsala University, P O Box 591, SE 751 24 Uppsala, Sweden
    Horm Behav 50:736-47. 2006
    ..In contrast to previous results, the outcome of the present investigation does not support the notion that a prolonged period of maternal separation results in an adult phenotype characterized by an increased emotional reactivity...
  38. pmc Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration
    T M Eriksson
    Center of Molecular Medicine, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Mol Psychiatry 17:173-84. 2012
    ....
  39. ncbi Strain and sex differences in anxiety-like and social behaviors in C57BL/6J and BALB/cJ mice
    Xiao Lei An
    Institute of Brain and Behavioral Sciences, Shaanxi Normal University, Xi an 710062, China
    Exp Anim 60:111-23. 2011
    ..This study provides important behavioral phenotypes and confirms the multidimensional behavioral structure of two widely used mice strains...
  40. pmc Steroid sulfatase-deficient mice exhibit endophenotypes relevant to attention deficit hyperactivity disorder
    Simon Trent
    Behavioural Genetics Group, Schools of Psychology and Medicine, Cardiff University, Cardiff, UK
    Psychoneuroendocrinology 37:221-9. 2012
    ....
  41. pmc Lack of involvement of alpha-synuclein in unconditioned anxiety in mice
    Yolanda Peña-Oliver
    Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Behav Brain Res 209:234-40. 2010
    ..Alpha-synuclein knock out mice and wild type controls displayed consistently similar emotionality profiles in all the tests, suggesting a lack of involvement of alpha-synuclein in unconditioned anxiety in mice...
  42. ncbi Voluntary exercise in C57 mice is anxiolytic across several measures of anxiety
    Jasmin N Salam
    Department of Psychology, University of Vermont, 2 Colchester Avenue, Burlington, VT 05405, USA
    Behav Brain Res 197:31-40. 2009
    ..Given the consistency of the anxiolytic effect of voluntary exercise across several measures, it is now possible to begin a systematic analysis of the physiological basis of the anxiolytic effect of exercise...
  43. pmc Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine
    S Rosi
    Brain and Spinal Injury Center, University of California, San Francisco, CA, USA
    Brain 132:2464-77. 2009
    ....
  44. pmc Striatal activity underlies novelty-based choice in humans
    Bianca C Wittmann
    Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London WC1N3BG, UK
    Neuron 58:967-73. 2008
    ..These data indicate that the brain uses perceptual novelty to approximate choice uncertainty in decision making, which in certain contexts gives rise to a newly identified and quantifiable source of human irrationality...
  45. ncbi Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii Dopamine, a missing link between schizophrenia and toxoplasmosis?
    Jaroslav Flegr
    Department of Parasitology, Charles University, Vinicna 7, 128 44, Prague, Czech Republic
    Biol Psychol 63:253-68. 2003
    ..003) and lower probability of achieving a higher education (P(2)<0.0000). Decrease of NS suggests that the increase of dopamine in brain of infected subjects can represent a missing link between toxoplasmosis and schizophrenia...
  46. ncbi Reactivation of experience-dependent cell assembly patterns in the hippocampus
    JOSEPH O'NEILL
    Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
    Nat Neurosci 11:209-15. 2008
    ..Together these data indicate that reactivated patterns are shaped by both positive and negative changes in cofiring, which are determined by recent behavior...
  47. pmc Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome
    Alexia M Thomas
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Brain Res 223:310-21. 2011
    ..Therefore, the goals for this study were to extend our understanding of the effects of modulating Gp1 mGluR activity on Fmr1 KO behavioral responses...
  48. ncbi Behavioural profiles of inbred mouse strains used as transgenic backgrounds. II: cognitive tests
    S P Brooks
    School of Biosciences, Cardiff University, and UWCM, Cardiff, UK
    Genes Brain Behav 4:307-17. 2005
    ....
  49. pmc Qualitatively different modes of perirhinal-hippocampal engagement when rats explore novel vs. familiar objects as revealed by c-Fos imaging
    Mathieu M Albasser
    School of Psychology, Cardiff University, 70 Park Place, Cardiff CF10 3AT, UK
    Eur J Neurosci 31:134-47. 2010
    ..This entorhinal switch provides a potential route by which the rhinal cortex can moderate hippocampal processing, with a dynamic change from temporo-ammonic (familiar stimuli) to perforant pathway (novel stimuli) influences...
  50. ncbi Behavioral effects of chronic fluoxetine in BALB/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptor
    Kerri A Holick
    Department of Pharmacology, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 33:406-17. 2008
    ..These findings suggest that SSRIs can produce antidepressant-like effects via distinct mechanisms in different mouse strains...
  51. ncbi The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids
    Aurelie A Boucher
    Department of Pharmacology, Bosch Institute, University of Sydney, Australia
    Int J Neuropsychopharmacol 14:631-43. 2011
    ..Furthermore, these data reinforce the notion that the VLS is an important brain region involved in Nrg1-cannabinoid interactions...
  52. ncbi Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system
    Pauline Lafenetre
    INSERM U862 NeuroCentre Magendie Université de Bordeaux, Equipe 8 Endocannabinoids and Neuroadaptation, 146 rue Leo Saignat, 33077 Bordeaux, France
    Neuropharmacology 57:715-21. 2009
    ..These data show a tightly regulated influence of the ECS on impulsive behaviors and suggest the involvement of endocannabinoid signaling in the pathophysiological modulation of ADHD and related disorders...
  53. pmc Estradiol and ERβ agonists enhance recognition memory, and DPN, an ERβ agonist, alters brain monoamines
    Luis F Jacome
    Biopsychology and Behavioral Science Subprogram, Graduate Program in Psychology, Graduate Center of City University of New York, NY 10016, USA
    Neurobiol Learn Mem 94:488-98. 2010
    ....
  54. pmc Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration
    Nicolas Maubourguet
    Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Institut Pasteur, Paris, France
    PLoS Comput Biol 4:e1000229. 2008
    ....
  55. ncbi One-trial object recognition in rats and mice: methodological and theoretical issues
    A Ennaceur
    University of Sunderland, Sunderland Pharmacy School, Wharncliffe Street, Sunderland, UK
    Behav Brain Res 215:244-54. 2010
    ..In addition, we discussed whether one-trial object recognition involves working memory and how it involves memory of an episode...
  56. ncbi Bidirectional cannabinoid modulation of social behavior in adolescent rats
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Psychopharmacology (Berl) 197:217-27. 2008
    ..Marijuana use in adolescents is a highly social activity, and interacting endocannabinoid and opioid systems may modulate social reward. However, cannabinoid exposure has been reported to reduce social behavior...
  57. ncbi Information theory, novelty and hippocampal responses: unpredicted or unpredictable?
    Bryan A Strange
    Wellcome Department of Imaging Neuroscience, Functional Imaging Laboratory, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Neural Netw 18:225-30. 2005
    ..In short, we show that the probabilistic structure or context in which events occur is an important predictor of hippocampal activity...
  58. pmc Paradoxical anxiogenic response of juvenile mice to fluoxetine
    Ji Eun Oh
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Neuropsychopharmacology 34:2197-207. 2009
    ....
  59. ncbi Fearfulness in red junglefowl and domesticated White Leghorn chickens
    Magnus Campler
    Division of Zoology, IFM Biology, Linkoping University, Linkoping, Sweden
    Behav Processes 81:39-43. 2009
    ..The results suggest that selection for low fearfulness has been an important element of domestication...
  60. pmc Intracellular determinants of hippocampal CA1 place and silent cell activity in a novel environment
    Jérôme Epsztein
    Bernstein Center for Computational Neuroscience, Humboldt University, Berlin 10115, Germany
    Neuron 70:109-20. 2011
    ..Our results provide new insight into hippocampal memory formation...
  61. ncbi Dead reckoning (path integration) requires the hippocampal formation: evidence from spontaneous exploration and spatial learning tasks in light (allothetic) and dark (idiothetic) tests
    I Q Whishaw
    Canadian Center for Behavioral Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Behav Brain Res 127:49-69. 2001
    ..These, tests of spontaneous exploration and foraging suggest a role for the hippocampal formation in dead reckoning...
  62. pmc New behavioral protocols to extend our knowledge of rodent object recognition memory
    Mathieu M Albasser
    School of Psychology, Cardiff University, Cardiff, CF10 3AT Wales, United Kingdom
    Learn Mem 17:407-19. 2010
    ..The overall findings demonstrate the efficacy of this new behavioral task and advance our understanding of object recognition...
  63. ncbi Differential modulation of CA1 and dentate gyrus interneurons during exploration of novel environments
    Douglas Nitz
    Department of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724, USA
    J Neurophysiol 91:863-72. 2004
    ....
  64. pmc Fear of novelty in infant rats predicts adult corticosterone dynamics and an early death
    S A Cavigelli
    Department of Psychology and Institute for Mind and Biology, University of Chicago, 940 East 57th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 100:16131-6. 2003
    ....
  65. ncbi Chronic restraint or variable stresses differently affect the behavior, corticosterone secretion and body weight in rats
    Marcelo T Marin
    Laboratory of Pharmacology, School of Pharmaceutical Sciences, UNESP Sao Paulo State University, Rod Araraquara Jaú Km 1, 14801 902, Araraquara, Sao Paulo, Brazil
    Physiol Behav 90:29-35. 2007
    ....
  66. ncbi Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior
    Andrew Holmes
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 28:2077-88. 2003
    ..findings demonstrate abnormal behavioral phenotypes in 5-HTT null mutant mice in tests for anxiety-like and exploratory behavior, and suggest a role for the 5-HT(1A) receptor in mediating these abnormalities...
  67. ncbi Mechanical characteristics of rat vibrissae: resonant frequencies and damping in isolated whiskers and in the awake behaving animal
    Mitra J Hartmann
    Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California 91109, USA
    J Neurosci 23:6510-9. 2003
    ..We discuss the potential roles of resonance during natural exploratory behavior and specifically suggest that resonant oscillations may be important in the rat's tactile detection of ..
  68. pmc The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, New York, USA
    Nat Protoc 2:322-8. 2007
    ..An increase in open arm activity (duration and/or entries) reflects anti-anxiety behavior. In our laboratory, rats or mice are exposed to the plus maze on one occasion; thus, results can be obtained in 5 min per rodent...
  69. ncbi Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task
    Lia R M Bevilaqua
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos 2600 Anexo Porto Alegre, RS 90035 003, Brazil
    Eur J Neurosci 17:897-902. 2003
    ..No action of this drug on locomotor/exploratory activity or general anxiety state could be detected. The significance of these results is discussed in the context of others describing the independence of LTM from STM...
  70. ncbi Heterozygous neuregulin 1 mice are more sensitive to the behavioural effects of Delta9-tetrahydrocannabinol
    A A Boucher
    Neuroscience Institute of Schizophrenia and Allied Disorders, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia
    Psychopharmacology (Berl) 192:325-36. 2007
    ..Cannabis use may precipitate schizophrenia especially if the individual has a genetic vulnerability to this mental disorder. Human and animal research indicates that neuregulin 1 (Nrg1) is a susceptibility gene for schizophrenia...
  71. ncbi The novelty exploration bonus and its attentional modulation
    Ruth M Krebs
    Department of Neurology and Center for Advanced Imaging, Otto von Guericke University, Magdeburg, Germany
    Neuropsychologia 47:2272-81. 2009
    ....
  72. ncbi Rearing on hind legs, environmental novelty, and the hippocampal formation
    Colin Lever
    Department ofAnatomy and Developmental Biology, University College London, London, UK
    Rev Neurosci 17:111-33. 2006
    ..The review concludes with testable predictions about rearing, environmental novelty and the hippocampus...
  73. pmc The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome
    Nadia P Belichenko
    Department of Neurology and Neurological Sciences and the Center for Research and Treatment of Down Syndrome, Stanford University Medical Center, Stanford, California 94305 5489, USA
    J Neurosci 29:5938-48. 2009
    ..The stage is now set for studies to decipher the gene(s) that play a conspicuous role in creating these phenotypes...
  74. ncbi The stress-induced hyperthermia paradigm as a physiological animal model for anxiety: a review of pharmacological and genetic studies in the mouse
    J Adriaan Bouwknecht
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neurosci Biobehav Rev 31:41-59. 2007
    ..The advantages and disadvantages of the SIH procedure as a physiological model of anxiety are discussed...
  75. ncbi Scototaxis as anxiety-like behavior in fish
    Caio Maximino
    Laboratório de Neurociências e Comportamento, Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, Brazil
    Nat Protoc 5:209-16. 2010
    ..When individual animals are exposed to the apparatus on only one occasion, results can be obtained in 20 min per fish...
  76. ncbi Relationship between dopamine system genes and extraversion and novelty seeking
    V E Golimbet
    Scientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow
    Neurosci Behav Physiol 37:601-6. 2007
    ..These results are consistent with current theoretical concepts of the regulation of dopamine transmission in the brain...
  77. pmc Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition
    Giulio Taglialatela
    Department of Neurosciences and Cell Biology, The University of Texas Medical Branch at Galveston, TX 77555, USA
    Behav Brain Res 200:95-9. 2009
    ..In human AD, CaN inhibition may lead the way for therapeutics to improve declarative memory performance as demonstrated in a mouse model for AD...
  78. ncbi Strain and gender differences in the behavior of mouse lines commonly used in transgenic studies
    V Voikar
    Laboratory of Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, PO Box 56, Viikinkaari 5, FIN 00014 Helsinki, Finland
    Physiol Behav 72:271-81. 2001
    ....
  79. ncbi Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal
    Alexandre Surget
    U930, INSERM, Universite Francois Rabelais de Tours, Tours, France
    Biol Psychiatry 64:293-301. 2008
    ..We investigated causality between changes in hippocampal neurogenesis and the effects of both chronic stress and chronic ADs...
  80. ncbi Improved behavior and neuropathology in the mouse model of Sanfilippo type IIIB disease after adeno-associated virus-mediated gene transfer in the striatum
    Arnaud Cressant
    Unité Rétrovirus et Transfert Génétique, Institut National de la Sante et de la Recherche Medicale, Paris, France
    J Neurosci 24:10229-39. 2004
    ..These results indicate that NaGlu delivery from intracerebral sources has the capacity to alleviate most disease manifestations in the MPSIIIB mouse model...
  81. ncbi Analyzing habituation responses to novelty in zebrafish (Danio rerio)
    Keith Wong
    Department of Pharmacology, Tulane University Medical School, New Orleans, LA 70112, USA
    Behav Brain Res 208:450-7. 2010
    ..In general, our study parallels literature on rodent habituation responses to novelty, and reconfirms zebrafish as a promising model for cognitive neurobehavioral research...
  82. pmc Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging
    Henrieta Scholtzova
    Department of Neurology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci Res 86:2784-91. 2008
    ..In addition, our study shows, for the first time, the utility of micro MRI in conjunction with gadolinium-labeled A beta labeling agents to monitor the therapeutic response to amyloid-reducing agents...
  83. ncbi Behavioral alterations induced by repeated testing in C57BL/6J and 129S2/Sv mice: implications for phenotyping screens
    V Voikar
    Neuroscience Center and Department of Biosciences, University of Helsinki, Finland
    Genes Brain Behav 3:27-38. 2004
    ..Therefore, the experience has substantial consequences on the behavior, mainly by reducing exploratory activity, and the previous experience of the animals has always to be considered in the analysis of genetically modified mice...
  84. ncbi Targeted gene deletion of the 5-HT3A receptor subunit produces an anxiolytic phenotype in mice
    Stephen P Kelley
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
    Eur J Pharmacol 461:19-25. 2003
    ..This evidence indicates that the 5-HT(3A) molecular subunit influences anxiety-like behavior. Pharmacotherapy that targets specifically the 5-HT(3A) receptor subunit may provide a novel treatment for anxiety disorders...
  85. pmc Anticipation of novelty recruits reward system and hippocampus while promoting recollection
    Bianca C Wittmann
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, UK
    Neuroimage 38:194-202. 2007
    ..In more general terms, the data suggest that dopaminergic processing of novelty might be important in driving exploration of new environments...
  86. pmc Object recognition memory and the rodent hippocampus
    Nicola J Broadbent
    Department of Psychiatry, University of California, La Jolla, California 92093, USA
    Learn Mem 17:5-11. 2010
    ..Hippocampal lesions produced moderate and reliable memory impairment. The results suggest that the hippocampus is important for object recognition memory...
  87. ncbi Enhanced anxiety, depressive-like behaviour and impaired recognition memory in mice with reduced expression of the vesicular glutamate transporter 1 (VGLUT1)
    R M Tordera
    Department of Pharmacology, University of Navarra, 31080 Pamplona, Spain
    Eur J Neurosci 25:281-90. 2007
    ..These observations suggest that a VGLUT1-mediated presynaptic alteration of the glutamatergic synapses, in specific brain regions, leads to a behavioural phenotype resembling certain aspects of psychiatric and cognitive disorders...
  88. ncbi Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
    Gerd Kempermann
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    Ann Neurol 52:135-43. 2002
    ..This cellular plasticity occurred in the context of significant improvements of learning parameters, exploratory behavior, and locomotor activity...
  89. ncbi Environmental enrichment reverses the impaired exploratory behavior and altered gene expression induced by early-life seizures
    Sookyong Koh
    Children s Memorial Hospital, Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    J Child Neurol 20:796-802. 2005
    ..To investigate the efficacy of environmental enrichment in reversing early-life seizure-induced changes in exploratory behavior and gene expression, we injected postnatal day 20 to 25 rats with kainic acid or saline and placed them ..
  90. ncbi Novelty responses to relational and non-relational information in the hippocampus and the parahippocampal region: a comparison based on event-related fMRI
    Stefan Köhler
    Department of Psychology, University of Western Ontario, London, Ontario, Canada
    Hippocampus 15:763-74. 2005
    ....
  91. ncbi Juvenile stress induces a predisposition to either anxiety or depressive-like symptoms following stress in adulthood
    Michael Tsoory
    Department of Psychology and The Brain and Behavior Research Center, University of Haifa, Mount Carmel, 31905 Haifa, Israel
    Eur Neuropsychopharmacol 17:245-56. 2007
    ..The results suggest that the presented "Juvenile stress" model may be relevant to the reported predisposition to develop both anxiety and depression following childhood trauma...
  92. ncbi The role of hippocampal subregions in detecting spatial novelty
    Inah Lee
    Center for Memory and Brain, Boston University, Boston, MA, USA
    Behav Neurosci 119:145-53. 2005
    ..The results suggest that the DG-CA3 network is essential in detecting novelty for spatial, but not for individual object, information...
  93. ncbi Ventromedial prefrontal cortex is obligatory for consolidation and reconsolidation of object recognition memory
    Irit Akirav
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    Cereb Cortex 16:1759-65. 2006
    ..These results indicate that both protein synthesis and NMDA receptors are required for consolidation and reconsolidation of recognition memory in the vmPFC...
  94. ncbi Ontogenesis of behavioral sensitization and conditioned place preference induced by psychostimulants in laboratory rodents
    Ezio Tirelli
    Behavioral Neuroscience and Experimental Psychopharmacology Laboratory, Department of Cognitive Sciences, University of Liege, Boulevard du Rectorat B32, B 4000 Liege, Belgium
    Neurosci Biobehav Rev 27:163-78. 2003
    ..These age-related changes do imply very different degrees of vulnerability to drug addiction and several other neuropsychiatric disorders...
  95. ncbi Antidepressant-like effects of serotonin type-3 antagonist, ondansetron: an investigation in behaviour-based rodent models
    Rajkumar Ramamoorthy
    Pharmacy Group, Birla Institute of Technology and Science, Faculty Division III, Pilani, Rajasthan, India
    Behav Pharmacol 19:29-40. 2008
    ..Summing up, it is observed that OND exhibits antidepressant-like effects, possibly mediated through postsynaptic 5-HT3 receptors...
  96. ncbi A follow-up study: acute behavioural effects of Delta(9)-THC in female heterozygous neuregulin 1 transmembrane domain mutant mice
    Leonora E Long
    Schizophrenia Research Institute, 405 Liverpool St, Darlinghurst, NSW 2010, Australia
    Psychopharmacology (Berl) 211:277-89. 2010
    ..We report data from a follow-up study in female Nrg1 HET mice, investigating THC effects on behaviours with some relevance to schizophrenia...
  97. pmc Lateral entorhinal cortex is critical for novel object-context recognition
    David I G Wilson
    School of Psychology, University of St Andrews, St Mary s Quad, St Andrews, Fife, United Kingdom
    Hippocampus 23:352-66. 2013
    ..This is consistent with the suggestion that contextual features of an event are processed in LEC and that this information is combined with spatial information from medial entorhinal cortex to form episodic memory in the hippocampus...
  98. ncbi Parametric analyses of anxiety in zebrafish scototaxis
    Caio Maximino
    Laboratório de Neurociências e Comportamento, Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem PA, Brazil
    Behav Brain Res 210:1-7. 2010
    ..In this work, we analyzed avoidance of the white compartment by analysis of the spatiotemporal pattern of exploratory behavior (time spent in the white compartment of the apparatus and shuttle frequency between compartments) and ..
  99. pmc Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humans
    David H Zald
    Department of Psychology, Vanderbilt University Nashville, Tennessee 37240, USA
    J Neurosci 28:14372-8. 2008
    ..We speculate that the lower midbrain (auto)receptor availability seen in high novelty seekers leads to accentuated dopaminergic responses to novelty and other conditions that induce dopamine release...
  100. ncbi Depressive-like-behavior and proinflamatory interleukine levels in the brain of rats submitted to pneumococcal meningitis
    Tatiana Barichello
    Laboratory of Experimental Microbiology and National Institute for Translational Medicine INCT TM, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806 000 Criciuma, SC, Brazil
    Brain Res Bull 82:243-6. 2010
    ..pneumoniae. These findings suggest that the meningitis model could be a good research tool for the study of the biological mechanisms involved in the behavioral alterations secondary to pneumococcal meningitis...
  101. ncbi Housing supplementation decreases the magnitude of inflammation-induced nociception in rats
    Jill M Tall
    Department of Biological Sciences, Youngstown State University, One University Plaza, Youngstown, OH 44555, USA
    Behav Brain Res 197:230-3. 2009
    ..These data indicate that environmental enrichment significantly affects nociceptive responses...

Research Grants62

  1. Sleep in Rats: From Conceptualization to Measurement, Analysis and Interpretation
    Gayle Giboney Page; Fiscal Year: 2010
    ..the in vivo immunosuppressive and tumor-enhancing effects of experimental laparotomy and normalize exploratory behavior. Inclusion of females in my experimental designs is a mainstay...
  2. MONOAMINE AND HALLUCINOGEN EFFECTS ON RODENT BEHAVIOR
    Mark A Geyer; Fiscal Year: 2013
    ..and identify the mechanism by which synthetic equivalents of Ayahuasca tea ("Pharmahuasca") alter exploratory behavior in rats...
  3. Rodent Behavioral Model of Ongoing Headache Pain
    ANDREW MARK STRASSMAN; Fiscal Year: 2013
    ..The core finding is a suppression of the normal exploratory behavior, and a concomitant increase in the amount of "resting'behavior or quiet wakefulness...
  4. Behavioral effects of deep brain stimulation in rats with chronic pain
    THOMAS JEFFREY MARTIN; Fiscal Year: 2013
    ..in rats following nerve injury othr than reflexive withdrawal from external stimuli include decreased exploratory behavior, increased anxiety-like behavior, conditioned place preference with analgesics, and analgesic self-..
  5. Operant Sensation Seeking in the Mouse
    Christopher M Olsen; Fiscal Year: 2013
    ..recombinant inbred strains of mice (BXDs) that are divergent in limbic structure, stress responsivity, and exploratory behavior. These data will reveal the contributions of genetic factors that underlie reinforcement and persistent "..
  6. Sensory pathways for stimulus detection during behavior
    Manuel A Castro-Alamancos; Fiscal Year: 2013
    ..We propose that the superior colliculus is a major sensory relay that serves to detect touch signals during exploratory behavior by differentiating movement-related and contact-related activity...
  7. Neurological sequelae in survivors of West Nile virus infection: a hamster model
    Cynthia Smeraski; Fiscal Year: 2009
    ..e. memory, Morris water maze, exploratory behavior), and 2) utilize immunohistochemistry to identify discrete regions of the nervous system that exhibit signs ..
  8. Neonatal Pain, Adult Biobehavioral Responses to Stress
    Gayle Page; Fiscal Year: 2005
    ..2) neuroendocrine outcomes: plasma levels of corticosterone and B-endorphin; and (3) behavioral outcomes: exploratory behavior, escape behavior and open field testing...
  9. DRUGS OF ABUSE--COMPLEXITY MEASURES CLASSIFY BEHAVIOR
    Mark Geyer; Fiscal Year: 1992
    ..and, second, a practical demonstration of the potential utility of this approach in the study of the exploratory behavior of rats...
  10. Satiety signaling in Caenorhabditis elegans
    Leon Avery; Fiscal Year: 2007
    ..C. elegans may also be subject to satiety: feeding motions and exploratory behavior are reduced when worms are starved for 24 hours, then refed for 6 hours. This study aims to define C...
  11. STARTLE GATING AND LOCOMOTION IN D2-FAMILY KNOCKOUT MICE
    Mark Geyer; Fiscal Year: 2004
    ..characterize the effects of amphetamine and selected direct dopamine agonists on patterns of locomotor and exploratory behavior in each of the mutant strains; and (5) characterize the effects of amphetamine and selected direct dopamine ..
  12. Central role of JNK/Jun cascade in visceral nociception
    Li Fang; Fiscal Year: 2006
    ..following visceral pain and determine if changes occur in cellular response of PSDC neurons, as well as in exploratory behavior; III) the expression of neurokinin NK1 receptors in spinal cord and PSDC neurons following inhibition of ..
  13. Information theoretic assays of exploration in aged mice
    Stephen Bonasera; Fiscal Year: 2007
    ..b>Exploratory behavior is modulated in a specific manner by different neurotransmitter systems; thus, sophisticated analyses of ..
  14. COCAINE EFFECTS ON ATTENTION AND AROUSAL IN NEONATES
    BERNARD KARMEL; Fiscal Year: 2000
    ..motivational development between 10 and 19 months, as measured by focused attention, distractibility, and exploratory behavior and (b) general cognitive growth particularly as altered by CNS status...
  15. INTRINSIC SYNAPTIC CIRCUITRY IN THE CEREBRAL CORTEX
    Asaf Keller; Fiscal Year: 2004
    ..Based on preliminary data we propose that SRFs are continually modulated by whisking frequency during exploratory behavior. We will test this hypothesis in vivo, and determine the mechanisms responsible for this dynamic regulation ..
  16. Dopamine and Exploration in Development
    Gregory Goodwin; Fiscal Year: 2004
    ..proposal is that an age-dependent enhancement of novelty-evoked accumbens dopamine activity facilitates exploratory behavior during the third postnatal week...
  17. Algorithm for drug discovery
    GREGORY ELMER; Fiscal Year: 2007
    ..Our approach uses an automated procedure for analyzing exploratory behavior in the open field...
  18. NITRIC OXIDE AND RESPONSES TO HYPOXIA IN DROSOPHILA
    PATRICK O FARRELL; Fiscal Year: 2003
    ..In preliminary work, we have shown that hypoxia induces an exploratory behavior in larvae, and arrests the cell cycle...
  19. MDMA & Amphetamine--Behavioral Organization in Mice
    Martin Paulus; Fiscal Year: 2003
    ..In rats, methamphetamine increases locomotor activity and exploratory behavior, has no effect on the geometric patterns of behavior but increases the unpredictability of movement ..
  20. PHENOTYPING OF EXPLORATORY BEHAVIOR
    Ilan Golani; Fiscal Year: 2002
    ..focus on establishing an objective, standardized, and high-throughput method for quantifying open field exploratory behavior in the mouse...
  21. VISUAL CONTROL OF MOBILITY IN LOW VISION
    Kathleen Turano; Fiscal Year: 2005
    ..Preliminary data demonstrate that VE is likely to be valid in studying exploratory behavior.
  22. DEVELOPMENTAL EFFECTS OF METHLENEDIOXYMETHAMPHETAMINE
    Charles Vorhees; Fiscal Year: 2002
    ..Such data will help identify risks associated with the prenatal use of MDMA on brain and cognitive development. ..
  23. Effects of Neonatal MDMA on Brain and Behavior
    Charles V Vorhees; Fiscal Year: 2010
    ....
  24. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2009
    ..The number of prenatally MA exposed children continues to grow. Our goal is to develop models of early MA exposure that permit an understanding of the long-term consequences on brain development and cognition. ..
  25. Social Anxiety Disorder and Emotion Regulation
    TODD KASHDAN; Fiscal Year: 2007
    ..Findings could ultimately lead to the development of more effective intervention efforts. [unreadable] [unreadable] [unreadable]..
  26. Risk for Depression Stress and Neuroendocrine Function
    AUDREY TYRKA; Fiscal Year: 2008
    ..This R01 proposal will entail a prospective longitudinal investigation of the effects of childhood adversity and maternal mood and anxiety disorders on the development of neuroendocrine dysfunction and psychopathology. ..
  27. The Amygdala, Individual Differences, and Conditioned Hyperactivity
    Mary Cain; Fiscal Year: 2007
    ..The findings of these experiments are intended to advance the understanding of vulnerability for stimulant abuse, and will potentially lead to better prevention and treatment interventions. [unreadable] [unreadable] [unreadable]..
  28. Aromatase regulation of paternal behavior and aggression
    BRIAN TRAINOR; Fiscal Year: 2002
    ..In summary, this proposal examines how aromatase mediates the effects of testosterone and social behavior. ..
  29. Estrogen receptors, photoperiod, and aggression
    BRIAN TRAINOR; Fiscal Year: 2007
    ..The proposed research should provide a novel and important framework to understand how the environment interacts with ER function to modulate behavior. ..
  30. The Amygdala and Amphetamine Self-Administration
    Mary Cain; Fiscal Year: 2003
    ..The findings from these experiments are intended to advance the understanding of vulnerability for stimulant abuse, and will potentially lead to better prevention and treatment interventions. ..
  31. OPTOTRAK MOTION MEASUREMENT SYSTEM
    KAREN ADOLPH; Fiscal Year: 2001
    ..abstract_text> ..
  32. Brain DHA, Dopamine, and Behavior: Roles in ADHD
    Beth Levant; Fiscal Year: 2006
    ..Such insights may identify a means by which certain risk factors for ADHD may be reduced or eliminated or the severity of the disease may be reduced through appropriate pre- and postnatal nutrition. [unreadable] [unreadable]..
  33. Behavioral Genetics and Toxic Response
    Edward Levin; Fiscal Year: 2002
    ....
  34. Cotinine for Cognitive Impairment in Neurological and Neuropsychiatric Disorders
    Alvin V Terry; Fiscal Year: 2010
    ..The partly translational design of the study will provide results leading to eventual clinical trials with cotinine or a relevant analog. ..
  35. Alcohol drinking behavior and prefrontal cortex neuron loss during adolescence
    JANICE JURASKA; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] ..
  36. Measuring Striatal Neurotransmission in Behaving Rats after Experimental TBI
    Amy Wagner; Fiscal Year: 2008
    ..the controlled cortical impact (CCI) model of experimental traumatic brain injury (TBI), spatial memory and exploratory behavior in novel environments is impaired...
  37. Dopamine Genetic Variants Modulating Recovery After TBI
    Amy Wagner; Fiscal Year: 2008
    ..Through neurolmaging, we hope to better understand how genetics Influences who may benefit from a relevant rehabilitation-based pharmacological treatment strategy. [unreadable] [unreadable] [unreadable]..
  38. RSA Lecture Series
    Jennifer Thomas; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  39. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  40. The Secure Base Function of Caregiving in Relationships
    BROOKE FEENEY; Fiscal Year: 2004
    ..g., influence on feelings of competency and exploratory behavior) and over time (e.g...
  41. Early Chronic Stress and Prefrontal Development
    David Lyons; Fiscal Year: 2005
    ..abstract_text> ..
  42. Genetics of spatial learning and memory
    Valerie Bolivar; Fiscal Year: 2005
    ..abstract_text> ..
  43. Dopamine Function in TBI--Therapeutic Intervention
    Amy Wagner; Fiscal Year: 2005
    ..The Departments of Physical Medicine and Rehabilitation, Neurosurgery, Anesthesia/Critical Care Medicine, and Safar Center for Resuscitation Research provide the environment for this study of experimental and clinical brain injury. ..
  44. Amphetamine Sensitization and Prefrontal Cortex Function
    JOSHUA GULLEY; Fiscal Year: 2005
    ..Ultimately, these experiments will help clarify the role of mPFC plasticity in behavioral sensitization and will further our understanding of the neuroadaptations associated with repeated drug intake. ..
  45. Amphetamine Sensitization: Role of Dopamine Transporters
    JOSHUA GULLEY; Fiscal Year: 2003
    ..These experiments will help elucidate the role of the DAT in behavioral sensitization and further our understanding of the neuroadaptations associated with repeated drug intake. ..
  46. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  47. Antipsychotics: Temporal Effects on Cognitive Function
    Alvin Terry; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  48. Infant-Mother Negotiation of Motor Risk
    KAREN ADOLPH; Fiscal Year: 2006
    ..abstract_text> ..
  49. Neuroimaging of shape similarity in object recognition
    Jane Joseph; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  50. Brain LC-PUFAs and Maternal Mental Health
    Beth Levant; Fiscal Year: 2006
    ..These findings will also suggest novel treatments for such illnesses when they occur. ..
  51. Genetics of complex behaviors in the mouse.
    Valerie Bolivar; Fiscal Year: 2007
    ..It is anticipated that the successful positional cloning of this gene will lead to new information on the pathways involved in the habituation process. ..
  52. Gender Differences in Dopamine Function after TBI
    Amy Wagner; Fiscal Year: 2003
    ....
  53. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  54. FLEXIBILITY OF LEARNING IN INFANT SKILL ACQUISITION
    KAREN ADOLPH; Fiscal Year: 2005
    ..In addition, results may have practical applications for promoting new skills in typically developing infants and children with motor impairments. ..
  55. DIFFERENTIAL FACIAL ENCODING IN MONKEY AMYGDALOID NUCLEI
    KATALIN GOTHARD; Fiscal Year: 2004
    ..abstract_text> ..
  56. HIV TREATMENT ADHERENCE FOR PERSONS WITH LOW-LITERACY
    Seth Kalichman; Fiscal Year: 2002
    ..Results of the proposed research will provide critical information about improving HIV treatment adherence with low-literacy populations that is needed prior to conducting larger and more expensive clinical trials. ..
  57. Brainstem-Diencephalic Modulation of the Hippocampus
    ROBERT VERTES; Fiscal Year: 2006
    ..This work may have important implications for disorders of memory including Korsakoff's syndrome, diencephalic amnesia and Alzheimer's disease. ..
  58. Dopaminergic Mechanisms of Reward in Schizophrenia
    James Gold; Fiscal Year: 2007
    ..If successful, the proposed work is designed to establish the conceptual foundation and preliminary data needed to support individual RO1 applications and a Translational Center. [unreadable] [unreadable]..