escape reaction

Summary

Summary: Innate response elicited by sensory stimuli associated with a threatening situation, or actual confrontation with an enemy.

Top Publications

  1. ncbi Omega-3 fatty acids and rodent behavior
    Irina Fedorova
    Laboratory of Membrane Biochemistry and Biophysics, National Institutes on Alcohol Abuse and Alcoholism, National Institutes of Health, MSC 9410, Bethesda, MD 20892 9410, USA
    Prostaglandins Leukot Essent Fatty Acids 75:271-89. 2006
  2. ncbi Prior electrical stimulation of dorsal periaqueductal grey matter or deep layers of the superior colliculus sensitizes rats to anxiety-like behaviors in the elevated T-maze test
    Leandro Pinto de Almeida
    Laboratory of Comparative Psychology, School of Psychology, University Estácio de Sá, 20260 060 Rio de Janeiro, RJ, Brazil
    Behav Brain Res 170:175-81. 2006
  3. ncbi Two months makes a difference in spatial orientation learning in very old FBNF1 rats
    F Josef van der Staay
    Institute of CNS Research, Bayer, Wuppertal, Germany
    Physiol Behav 87:659-65. 2006
  4. ncbi Effects of escapable and inescapable stressors on behavior and interleukin-2 in the brain
    Yen Ti Lee
    Institute of Behavioral Medicine, Cheng Kung University, Taiwan, Republic of China
    Neuroreport 19:1243-7. 2008
  5. ncbi Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task
    Lia R M Bevilaqua
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos 2600 Anexo Porto Alegre, RS 90035 003, Brazil
    Eur J Neurosci 17:897-902. 2003
  6. pmc Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons
    Adam D Douglass
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Curr Biol 18:1133-7. 2008
  7. pmc Nociceptive neurons protect Drosophila larvae from parasitoid wasps
    Richard Y Hwang
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Biol 17:2105-16. 2007
  8. ncbi Animal escapology I: theoretical issues and emerging trends in escape trajectories
    Paolo Domenici
    CNR IAMC Localitá Sa Mardini, 09072 Torregrande Or, Italy
    J Exp Biol 214:2463-73. 2011
  9. pmc Animal escapology II: escape trajectory case studies
    Paolo Domenici
    CNR IAMC Localitá Sa Mardini, 09072 Torregrande Or, Italy
    J Exp Biol 214:2474-94. 2011
  10. ncbi Risk assessment as an evolved threat detection and analysis process
    D Caroline Blanchard
    Pacific Biosciences Research Center and Department of Genetics and Molecular Biology, John A Burns School of Medicine, University of Hawaii, United States
    Neurosci Biobehav Rev 35:991-8. 2011

Research Grants

  1. AMYGDALOID FUNCTION IN FEAR CONDITIONING
    Stephen Maren; Fiscal Year: 2009
  2. Volatile Anesthetic Action in Vertebrate Locomotor Systems
    Steven L Jinks; Fiscal Year: 2010
  3. PPM-PREP: Peer-Mentored Preparedness for Adults with Developmental Disabilities
    DAVID PAUL EISENMAN; Fiscal Year: 2010
  4. Viral Encephalitis, Chemokines and Sleep
    LARRY D contact SANFORD; Fiscal Year: 2010
  5. Fear memory formation in early life
    Christoph Wiedenmayer; Fiscal Year: 2007
  6. ESCAPE BEHAVIOR--INTEGRATION AND PLASTICITY
    FRANKLIN KRASNE; Fiscal Year: 2005
  7. ALTERING BEHAVIORAL RISK FOR DRUG DEPENDENCE
    DON CHEREK; Fiscal Year: 2001
  8. BEHAVIORAL MECHANISM IN HIGH RISK POPULATIONS
    DON CHEREK; Fiscal Year: 2001
  9. JWatcher-event recorder and behavioral analysis program
    DANIEL BLUMSTEIN; Fiscal Year: 2004
  10. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2009

Detail Information

Publications236 found, 100 shown here

  1. ncbi Omega-3 fatty acids and rodent behavior
    Irina Fedorova
    Laboratory of Membrane Biochemistry and Biophysics, National Institutes on Alcohol Abuse and Alcoholism, National Institutes of Health, MSC 9410, Bethesda, MD 20892 9410, USA
    Prostaglandins Leukot Essent Fatty Acids 75:271-89. 2006
    ..The possible role of non-cognitive factors like emotionality and attention in the impaired performance of n-3 fatty acid deficient animals also requires further investigation...
  2. ncbi Prior electrical stimulation of dorsal periaqueductal grey matter or deep layers of the superior colliculus sensitizes rats to anxiety-like behaviors in the elevated T-maze test
    Leandro Pinto de Almeida
    Laboratory of Comparative Psychology, School of Psychology, University Estácio de Sá, 20260 060 Rio de Janeiro, RJ, Brazil
    Behav Brain Res 170:175-81. 2006
    ..Besides, the data supports the view that prior electrical stimulation of DPAG and DLSC is selective in sensitizing rats to anxiety-like behaviors, but not to panic-like behaviors in the elevated T-maze test...
  3. ncbi Two months makes a difference in spatial orientation learning in very old FBNF1 rats
    F Josef van der Staay
    Institute of CNS Research, Bayer, Wuppertal, Germany
    Physiol Behav 87:659-65. 2006
    ..If there are not sufficient animals from one batch, it may be worthwhile to combine animals from different batches per age group, provided that breeding, rearing, housing, and testing conditions are highly standardized...
  4. ncbi Effects of escapable and inescapable stressors on behavior and interleukin-2 in the brain
    Yen Ti Lee
    Institute of Behavioral Medicine, Cheng Kung University, Taiwan, Republic of China
    Neuroreport 19:1243-7. 2008
    ..These data provide insight into the pathophysiological role of IL-2 in stress-related disorders...
  5. ncbi Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task
    Lia R M Bevilaqua
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos 2600 Anexo Porto Alegre, RS 90035 003, Brazil
    Eur J Neurosci 17:897-902. 2003
    ..No action of this drug on locomotor/exploratory activity or general anxiety state could be detected. The significance of these results is discussed in the context of others describing the independence of LTM from STM...
  6. pmc Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons
    Adam D Douglass
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Curr Biol 18:1133-7. 2008
    ..These results establish ChR2 as a powerful tool for the manipulation of neural activity in zebrafish and reveal a degree of efficiency in coding that has not been found in primary sensory neurons...
  7. pmc Nociceptive neurons protect Drosophila larvae from parasitoid wasps
    Richard Y Hwang
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Biol 17:2105-16. 2007
    ..In response, the larvae "roll" with a motor pattern that is completely distinct from the style of locomotion that is used for foraging...
  8. ncbi Animal escapology I: theoretical issues and emerging trends in escape trajectories
    Paolo Domenici
    CNR IAMC Localitá Sa Mardini, 09072 Torregrande Or, Italy
    J Exp Biol 214:2463-73. 2011
    ....
  9. pmc Animal escapology II: escape trajectory case studies
    Paolo Domenici
    CNR IAMC Localitá Sa Mardini, 09072 Torregrande Or, Italy
    J Exp Biol 214:2474-94. 2011
    ....
  10. ncbi Risk assessment as an evolved threat detection and analysis process
    D Caroline Blanchard
    Pacific Biosciences Research Center and Department of Genetics and Molecular Biology, John A Burns School of Medicine, University of Hawaii, United States
    Neurosci Biobehav Rev 35:991-8. 2011
    ..An especially intriguing possibility is that mirror neurons may respond to some of the same types of situational differences that are analyzed during risk assessment, suggesting an additional functional role for these neurons...
  11. ncbi Behavioural and kinematic components of the fast-start escape response in fish: individual variation and temporal repeatability
    Stefano Marras
    UMR 5554, Institut des Sciences de l Evolution de Montpellier, Université de Montpellier 2, Station Mediterraneenne de l Environnement Littoral, 2 rue des Chantiers, F 34200 Sète, France
    J Exp Biol 214:3102-10. 2011
    ....
  12. ncbi Effects of Lorazepam and citalopram on human defensive reactions: ethopharmacological differentiation of fear and anxiety
    Adam M Perkins
    Centre for Neuroimaging Sciences, Institute of Psychiatry, London SE5 8AF, UK
    J Neurosci 29:12617-24. 2009
    ..These data also contribute to the validation of a novel human analog of an established experimental model of rodent fear and anxiety...
  13. pmc Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain
    Minoru Koyama
    Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 108:1170-5. 2011
    ..Many different specialized hindbrain networks may arise similarly from a simple early patterning...
  14. pmc Anthropogenic noise affects risk assessment and attention: the distracted prey hypothesis
    Alvin Aaden Yim Hol Chan
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095 1606, USA
    Biol Lett 6:458-61. 2010
    ..Anthropogenic sounds may thus distract prey and make them more vulnerable to predation...
  15. ncbi Initiation of Mauthner- or non-Mauthner-mediated fast escape evoked by different modes of sensory input
    Tsunehiko Kohashi
    Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464 8602, Japan
    J Neurosci 28:10641-53. 2008
    ..These results suggest that M-cell firing is necessary for fast escape with short latency elicited by acousticovestibular input and that MiD3cm is more involved in non-M-escape driven by head-tactile input...
  16. ncbi Evidence for a widespread brain stem escape network in larval zebrafish
    Ethan Gahtan
    Department of Biology, Northeastern University, Boston, Massachusetts 02115, USA
    J Neurophysiol 87:608-14. 2002
    ..The degree of robustness or redundancy of this system has implications for the descending control of vertebrate locomotion...
  17. pmc Fear in animals: a meta-analysis and review of risk assessment
    Theodore Stankowich
    Department of Psychology, University of California Animal Behavior Graduate Group, Davis, CA 95616, USA
    Proc Biol Sci 272:2627-34. 2005
    ..We find that selection generally acts on prey to be sensitive to predator behaviour, as well as on prey to modify their behaviour and morphology...
  18. pmc Behavioural asymmetry affects escape performance in a teleost fish
    Marco Dadda
    Department of General Psychology, University of Padova, Italy
    Biol Lett 6:414-7. 2010
    ..Therefore, lateralization is likely to result in superior ability to escape from predator attacks, since previous work has shown that escape timing, turning rate and distance travelled are among the main determinants of escape success...
  19. ncbi Escape performance decreases during ontogeny in wild crickets
    O Dangles
    Universite de Tours, IRBI UMR CNRS 6035, Parc Grandmont, 37200 Tours, France
    J Exp Biol 210:3165-70. 2007
    ..We expect that our analysis of size-refuge will also improve our understanding in the development of performance, given its importance in community and population ecology theories...
  20. pmc An alternative theoretical approach to escape decision-making: the role of visual cues
    Veronika Javůrková
    Department of Zoology, Biodiversity Research Group, Charles University, Prague, Czech Republic
    PLoS ONE 7:e32522. 2012
    ....
  21. pmc Neural activity associated with monitoring the oscillating threat value of a tarantula
    Dean Mobbs
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 7EF, United Kingdom
    Proc Natl Acad Sci U S A 107:20582-6. 2010
    ..Our findings fractionate the neurobiological mechanisms associated with basic fear and potentially illuminate the perturbed reactions that characterize clinical phobias...
  22. pmc Learning temporal patterns of risk in a predator-diverse environment
    Yoland J Bosiger
    ARC Centre of Excellence for Coral Reef Studies, and School of Marine and Tropical Biology, James Cook University, Townsville, Queensland, Australia
    PLoS ONE 7:e34535. 2012
    ..Our results provide the first experimental demonstration of a mechanism by which prey in a complex, multi-predator environment can learn and respond to daily patterns of predation risk...
  23. pmc Lesion of the ventral periaqueductal gray reduces conditioned fear but does not change freezing induced by stimulation of the dorsal periaqueductal gray
    D M Vianna
    , Faculdade Filosofia, , , , SP, Brasil
    Learn Mem 8:164-9. 2001
    ..A discussion on different neural circuitries that might underlie different inhibitory and active defensive behavioral patterns that animals display during threatening situations is presented...
  24. pmc A tyramine-gated chloride channel coordinates distinct motor programs of a Caenorhabditis elegans escape response
    Jennifer K Pirri
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Neuron 62:526-38. 2009
    ..Activation of LGC-55 by tyramine coordinates the output of two distinct motor programs, locomotion and head movements that are critical for a C. elegans escape response...
  25. pmc Collective defense of Aphis nerii and Uroleucon hypochoeridis (Homoptera, Aphididae) against natural enemies
    Manfred Hartbauer
    Behavioural Ecology Group, Department of Zoology, Karl Franzens University Graz, Graz, Austria
    PLoS ONE 5:e10417. 2010
    ..This cooperative defense behavior provides an example of a surprising sociality that can be found in some aphid species that are not expected to be social at all...
  26. ncbi Infrasound initiates directional fast-start escape responses in juvenile roach Rutilus rutilus
    Hans E Karlsen
    Institute of Biology, University of Oslo, Blindern N 0316, Norway
    J Exp Biol 207:4185-93. 2004
    ..We conclude that particle acceleration is essential for the directionality of the startle response to infrasound, and that the response is triggered by the synergistic effects of acceleration and compression...
  27. ncbi Optimal flight initiation distance
    William E Cooper
    Department of Biology, Indiana University Purdue University Fort Wayne, Fort Wayne, IN 46805, USA
    J Theor Biol 244:59-67. 2007
    ....
  28. ncbi Behavioural responses of hatchery-reared and wild cod Gadus morhua to mechano-acoustic predator signals
    J J Meager
    Department of Biology, University of Bergen, P O Box 7800, Bergen N 5020, Norway
    J Fish Biol 78:1437-50. 2011
    ..This suggests that experience plays a role in shaping the behavioural response of fishes to MA stimuli...
  29. ncbi Functional role of a specialized class of spinal commissural inhibitory neurons during fast escapes in zebrafish
    Chie Satou
    National Institutes of Natural Sciences, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, Okazaki, Aichi 444 8787, Japan
    J Neurosci 29:6780-93. 2009
    ..This study illustrates (1) a clear example of the behavioral role of a specialized class of interneurons and (2) the capacity of the spinal circuits to filter descending commands and thereby produce the appropriate behavior...
  30. ncbi Mammalian herbivore breath alerts aphids to flee host plant
    Moshe Gish
    Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel
    Curr Biol 20:R628-9. 2010
    ..The pea aphids' highly adaptive escape behavior uniquely demonstrates the strength of the selective pressure large mammalian herbivores impose on insect herbivores...
  31. ncbi The fear-avoidance model of musculoskeletal pain: current state of scientific evidence
    Maaike Leeuw
    Department of Medical, Clinical, and Experimental Psychology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    J Behav Med 30:77-94. 2007
    ..Finally, available evidence on recent clinical applications is provided, and unresolved issues that need further exploration are discussed...
  32. ncbi Behavioral measures of anxiety in zebrafish (Danio rerio)
    R E Blaser
    Department of Psychology, University of San Diego, 5998 Alcala Park, San Diego, CA 92110, USA
    Behav Brain Res 208:56-62. 2010
    ..Freezing is therefore suggested to be a viable measure of white-induced anxiety, while interpretation of the other behaviors is more ambiguous and will require further investigation...
  33. ncbi A two-dimensional neuropsychology of defense: fear/anxiety and defensive distance
    Neil McNaughton
    Department Psychology and Neuroscience Research Centre, University of Otago, P O Box 56 Dunedin, New Zealand
    Neurosci Biobehav Rev 28:285-305. 2004
    ..Our current development and these proposed future extensions do not change the core concepts originally proposed by Gray and, we argue, demonstrate their enduring value...
  34. ncbi Lateralization in the escape behaviour of the common wall lizard (Podarcis muralis)
    Beatrice Bonati
    Dipartimento di Biologia Evolutiva e Funzionale, Sezione Museo di Storia Naturale, Universita di Parma, via Farini 90, Parma, Italy
    Behav Brain Res 207:1-6. 2010
    ..Moreover, we found a left bias in turning the head for monitoring the predatory stimulus during escape, supporting the hypothesis that such a preference is likely due to visual lateralization rather than to motor lateralization...
  35. ncbi Avoiding incidental predation by mammalian herbivores: accurate detection and efficient response in aphids
    Moshe Gish
    Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel
    Naturwissenschaften 98:731-8. 2011
    ..The accurate and efficient defense mechanism of U. sonchi emphasizes the significance of incidental predation as a danger to plant-dwelling invertebrates...
  36. ncbi S- and C-start escape responses of the muskellunge (Esox masquinongy) require alternative neuromotor mechanisms
    Melina E Hale
    Department of Organismal Biology and Anatomy, University of Chicago, 1027 East 57th Street, Chicago, IL 60637, USA
    J Exp Biol 205:2005-16. 2002
    ..Alternative models are proposed for S-start neural circuit organization involving reticulospinal and local control of muscle activity...
  37. ncbi Predator avoidance behavior in the pea aphid: costs, frequency, and population consequences
    Erik H Nelson
    Center for Population Biology, Department of Entomology, University of California, Davis, CA 95616, USA
    Oecologia 151:22-32. 2007
    ....
  38. pmc A novel thermosensitive escape behavior in Drosophila larvae
    Matthew Oswald
    Department of Biology and Hull York Medical School, University of York, York, England UK
    Fly (Austin) 5:304-6. 2011
    ..This response is highly reproducible and directly applicable to genetic and neural circuit analysis of a simple escape behavior...
  39. ncbi Accelerometer tags: detecting and identifying activities in fish and the effect of sampling frequency
    Franziska Broell
    Department of Oceanography, Dalhousie University, 1355 Oxford Street, Halifax, NS, Canada, B3H 4R2
    J Exp Biol 216:1255-64. 2013
    ..If battery and/or data storage is limited, we also recommend archiving the events via an on-board algorithm that determines the highest likelihood and subsequent archiving of the various event classes of interest...
  40. ncbi Neuromodulation intrinsic to the central pattern generator for escape swimming in Tritonia
    P S Katz
    Department of Biology, Georgia State University, Atlanta 30302, USA
    Ann N Y Acad Sci 860:181-8. 1998
    ..These neuromodulatory actions intrinsic to the CPG may be important for the initial self-configuration of the system into a function CPG and for experience-dependent changes in the output such as behavioral sensitization and habituation...
  41. pmc Temporal learning of predation risk by embryonic amphibians
    Maud C O Ferrari
    Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, SK, Canada, S7N 5E2
    Biol Lett 6:308-10. 2010
    ....
  42. ncbi Escape behaviors in insects
    Gwyneth M Card
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, United States
    Curr Opin Neurobiol 22:180-6. 2012
    ....
  43. ncbi Partial tail loss has no severe effects on energy stores and locomotor performance in a lacertid lizard, Takydromus septentrionalis
    Zhi hua Lin
    Jiangsu Key Laboratory for Bioresource Technology, College of Life Sciences, Nanjing Normal University, Jiangsu, People s Republic of China
    J Comp Physiol B 175:567-73. 2005
    ..Our data show that partial tail loss due to predatory encounters or other factors may not severely affect energy stores and locomotor performance in T. septentrionalis...
  44. pmc The neuroethology of C. elegans escape
    Jennifer K Pirri
    Department of Neurobiology, LRB 717, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Opin Neurobiol 22:187-93. 2012
    ..elegans, enables a comprehensive neuroethological analysis of behavior. In this review we discuss the neuronal mechanisms and the ecological significance of the C. elegans touch response...
  45. ncbi Behavioral characterization of the alarm reaction and anxiolytic-like effect of acute treatment with fluoxetine in piauçu fish
    Augusto Barbosa Júnior
    Laboratory of Comparative Neurophysiology and Neuroanatomy, Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP 14049 900, Brazil
    Physiol Behav 105:784-90. 2012
    ..In addition, fluoxetine treatment caused an anxiolytic-like effect following CAS exposure. Thus, the alarm reaction in piauçu can be a useful model for neuroethological and pharmacological studies of anxiety-related states...
  46. pmc The aerodynamic signature of running spiders
    Jerome Casas
    University of Tours, Institut de Recherches sur la Biologie de l Insecte, UMR CNRS 6035, 37200 Tours, France
    PLoS ONE 3:e2116. 2008
    ..These findings may be relevant to the large and diverse array of arthropod prey-predator interactions in leaf litter...
  47. ncbi Danger detection and escape behaviour in wood crickets
    Fabienne Dupuy
    Institut de Recherche sur la Biologie de l Insecte, UMR 6035 CNRS Université François Rabelais, av Monge, Parc Grandmont, 37200 Tours, France
    J Insect Physiol 57:865-71. 2011
    ..Nevertheless, neither antennae nor eyes seem to be used for detecting approaching objects, as their inactivation did not reduce their detection and escape abilities in the presence of cerci...
  48. ncbi Molt-related and size-dependent differences in the escape response and post-threat behavior of the American lobster, Homarus americanus
    S I Cromarty
    Biological Sciences Department, University of Rhode Island, Kingston 02881, USA
    Biol Bull 199:265-77. 2000
    ....
  49. ncbi The Mauthner cell half a century later: a neurobiological model for decision-making?
    Henri Korn
    Laboratoire Recepteurs et Cognition, CNRS, URA 2182, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Neuron 47:13-28. 2005
    ..The M cell sets the behavioral threshold, and, acting in concert with other elements of the brainstem escape network, determines when, where, and how the escape is executed...
  50. ncbi In vivo imaging of zebrafish reveals differences in the spinal networks for escape and swimming movements
    D A Ritter
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794-5230, USA
    J Neurosci 21:8956-65. 2001
    ..The observations lead to predictions of different behavioral roles for particular classes of spinal interneurons that can eventually be tested directly in zebrafish by using laser ablations or mutant lines with interneuronal deficits...
  51. ncbi Role of an identified looming-sensitive neuron in triggering a flying locust's escape
    Roger D Santer
    School of Biology and Psychology, Ridley Building, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU, United Kingdom
    J Neurophysiol 95:3391-400. 2006
    ..This means that the locust's escape behavior can vary in response to the same looming stimulus, meaning that a predator cannot exploit predictability in the locust's collision avoidance behavior...
  52. ncbi Neuroanatomy of anxiety
    Newton Sabino Canteras
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Curr Top Behav Neurosci 2:77-96. 2010
    ..In addition, recent neuroimaging studies also suggest dysfunctions in these systems are probably related to anxiety disorders in humans...
  53. ncbi Role of nitric oxide in brain regions related to defensive reactions
    F S Guimaraes
    Department of Pharmacology, School of Medicine, FMRP, University of Sao Paulo, Ribeirao Preto, SP 14049 900, Brazil
    Neurosci Biobehav Rev 29:1313-22. 2005
    ..These results suggest a modulatory role for NO on brain areas related to defensive reactions, probably by interacting with glutamate, serotonin and/or GABA-mediated neurotransmission...
  54. ncbi Dorsal raphe nucleus regulation of a panic-like defensive behavior evoked by chemical stimulation of the rat dorsal periaqueductal gray matter
    Tatiana Longo Borges Miguel
    Department of Pharmacology, School of Medicine, University of Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, CEP, Brazil
    Behav Brain Res 213:195-200. 2010
    ..However, both compounds fully blocked the escape reaction generated by intra-DPAG injection of the excitatory amino acid d,l-homocysteic acid (DLH)...
  55. ncbi Exploitation of an ancient escape circuit by an avian predator: relationships between taxon-specific prey escape circuits and the sensitivity to visual cues from the predator
    P G Jabłoński
    ARL Division Neurobiology, University of Arizona, Tucson, USA
    Brain Behav Evol 58:218-40. 2001
    ..The present results suggest that these several properties of escape pathways have contributed to the evolution of foraging displays and plumage patterns in flush-pursuing birds...
  56. ncbi Increased plasma corticosterone levels after periaqueductal gray stimulation-induced escape reaction or panic attacks in rats
    Lee Wei Lim
    Department of Neuroscience, Maastricht University, The Netherlands
    Behav Brain Res 218:301-7. 2011
    ..In conclusion, the present study clearly demonstrated that PA or escape response activates the HPA axis and it remains difficult to anticipate the mechanism underlying HPA axis during PAs and its relationship with 5-HT drugs...
  57. ncbi NOC-9, a selective nitric oxide donor, induces flight reactions in the dorsolateral periaqueductal gray of rats by activating soluble guanylate cyclase
    Andréa Arantes Braga
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, SP 14049900, Brazil
    Neurosci Lett 459:79-83. 2009
    ..Moreover, they also indicate that these defensive responses depend on activation of local sGC. The data strengthen the proposal that NO can modulate defensive reactions in the dlPAG...
  58. ncbi Neural representation of object approach in a decision-making motor circuit
    Thomas Preuss
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 26:3454-64. 2006
    ....
  59. pmc Relationship between the phases of sensory and motor activity during a looming-evoked multistage escape behavior
    Haleh Fotowat
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:10047-59. 2007
    ..Our results therefore suggest that distinct phases of the firing patterns of individual sensory neurons may actively contribute to distinct phases of complex, multistage motor behaviors...
  60. pmc From threat to fear: the neural organization of defensive fear systems in humans
    Dean Mobbs
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1 3BG, United Kingdom
    J Neurosci 29:12236-43. 2009
    ....
  61. ncbi Collision detection as a model for sensory-motor integration
    Haleh Fotowat
    Department of Biology, McGill University, Montreal, Quebec, H3A 1B1, Canada
    Annu Rev Neurosci 34:1-19. 2011
    ..A combination of behavioral and in vivo electrophysiological experiments has unraveled many of the cellular and network mechanisms underlying this behavior...
  62. ncbi Escape behavior and neuronal responses to looming stimuli in the crab Chasmagnathus granulatus (Decapoda: Grapsidae)
    Damian Oliva
    Laboratorio de Neurobiologia de la Memoria, Depto Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE CONICET, Buenos Aires 1428, Argentina
    J Exp Biol 210:865-80. 2007
    ..Thereafter, the neurons abruptly stop firing and the animal immediately decelerates its run. The results are discussed in connection with studies of responses to looming stimuli in the locust...
  63. ncbi The predictive start of hunting archer fish: a flexible and precise motor pattern performed with the kinematics of an escape C-start
    Saskia Wöhl
    Universitat Erlangen Nurnberg, Institut für Zoologie II, Staudtstrasse 5, D 91058 Erlangen, Germany
    J Exp Biol 210:311-24. 2007
    ..How the network drives such a rather complex behavior without compromising speed is a wide open question...
  64. ncbi Escape behavior and escape circuit activation in juvenile crayfish during prey-predator interactions
    Jens Herberholz
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    J Exp Biol 207:1855-63. 2004
    ..Overall, tail flipping was found to be a successful behavior in preventing predation, and only a small percentage of crayfish were killed and consumed...
  65. ncbi Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats
    D P Finn
    Institute of Neuroscience, School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Neuropharmacology 45:594-604. 2003
    ..Mechanisms mediating the anti-aversive effects of cannabinoids in the PAG remain to be elucidated. These data implicate a role for the PAG in both cannabinoid-mediated anti-nociceptive and anti-aversive responses...
  66. pmc When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans
    Dean Mobbs
    Wellcome Trust Centre for Neuroimaging, Functional Imaging Laboratory, University College London, London WC1N 3BG, UK
    Science 317:1079-83. 2007
    ..Our findings cast light on the neural dynamics of threat anticipation and have implications for the neurobiology of human anxiety-related disorders...
  67. ncbi Input and output characteristics of collision avoidance behavior in the frog Rana catesbeiana
    Keisuke Yamamoto
    Department of Brain Science and Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu, Fukuoka 808 0196, Japan
    Brain Behav Evol 62:201-11. 2003
    ..07, F(2,14) = 0.46 and F(2,14) = 0.70, respectively; at 4 m/s, F(2,15) = 0.50, F(2,14) = 0.68 and F(2,14) = 0.41, respectively, p > 0.05). Thus, frog collision avoidance behavior seems to have an all or none-like property...
  68. ncbi Escapes with and without preparation: the neuroethology of visual startle in locusts
    Peter J Simmons
    Institute of Neuroscience and School of Biology, Ridley Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
    J Insect Physiol 56:876-83. 2010
    ....
  69. ncbi Involvement of 5-HT1A and 5-HT2 receptors of the dorsal periaqueductal gray in the regulation of the defensive behaviors generated by the elevated T-maze
    Vanessa de Paula Soares
    a Department of Pharmacology, School of Medicine, University of Sao Paulo, 14049 900 Ribeirao Preto, SP, Brazil
    Brain Res Bull 64:181-8. 2004
    ..Both 5-HT1A, 5-HT2A and 5-HT2C receptors seem to mediate the inhibitory action of serotonin on escape...
  70. ncbi Step response analysis of thermotaxis in Caenorhabditis elegans
    Hatim A Zariwala
    Graduate Program in Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    J Neurosci 23:4369-77. 2003
    ..Our results suggest that sensory systems for thermotaxis and chemotaxis may converge on a common behavioral mechanism...
  71. ncbi High-frequency stimulation of the dorsolateral periaqueductal gray and ventromedial hypothalamus fails to inhibit panic-like behaviour
    Lee Wei Lim
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Behav Brain Res 193:197-203. 2008
    ..The neuronal activation pattern resulting from dlPAG and VMH DBS was similar. These findings suggest that DBS of the dlPAG and VMH induces panic-related behaviours even at higher frequencies...
  72. ncbi Involvement of hippocampal nitric oxide in spatial learning in the rat
    Nahid Majlessi
    Department of Physiology and Pharmacology, Pasteur Institute of Iran, Pasteur Ave, Tehran 1316943551, Iran
    Neurobiol Learn Mem 90:413-9. 2008
    ..2 microg, increased heading angle (p<0.01) with no effect on other parameters. On the basis of the present data, it is concluded that processes mediated by NO synthesis in the hippocampus are essentially involved in spatial learning...
  73. ncbi The chemical defense ecology of marine unicellular plankton: constraints, mechanisms, and impacts
    G V Wolfe
    Shannon Pt Marine Center, Western Washington University, Anacortes 98221, USA
    Biol Bull 198:225-44. 2000
    ..Although the exploration of chemical interactions among planktonic microbes is in its infancy, ecological models from macroorganisms provide useful hints of the complexity likely to be found...
  74. ncbi A multi-stage anti-predator response increases information on predation risk
    Jan M Hemmi
    ARC Centre of Excellence in Vision Science and Centre for Visual Sciences, Evolution, Ecology and Genetics, Research School of Biology, The Australian National University, Canberra, ACT 0200, Australia
    J Exp Biol 213:1484-9. 2010
    ..By concentrating on sensory limitations, we can quantify such information deficits and investigate how improving risk assessment helps prey optimise the balance between predation risk and escape costs...
  75. ncbi Local inhibition of hippocampal nitric oxide synthase does not impair place learning in the Morris water escape task in rats
    A Blokland
    Faculty of Psychology, European Graduate School of Neuroscience EURON Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands
    Eur J Neurosci 11:223-32. 1999
    ..On the basis of the present data it was concluded that hippocampal NO is not critically involved in place learning in rats...
  76. ncbi Parasitoid wasp uses a venom cocktail injected into the brain to manipulate the behavior and metabolism of its cockroach prey
    Ram Gal
    Department of Life Sciences, Ben Gurion University, Beer Sheva, Israel
    Arch Insect Biochem Physiol 60:198-208. 2005
    ..The alteration in the octopaminergic neurons' activity could be one of the mechanisms by which the venom modulates the escape circuit in the cockroach's central nervous system and metabolism in the peripheral system...
  77. ncbi Wind generated by an attacking bat: anemometric measurements and detection by the praying mantis cercal system
    Jeffrey D Triblehorn
    Department of Psychology, University of Maryland, College Park, 20742, USA
    J Exp Biol 209:1430-40. 2006
    ..Although it probably would not have time for a full response that completely evades the bat, even a partial response might alter the mantid's trajectory enough to cause the bat to mishandle the insect, allowing it to escape...
  78. ncbi Descending influences on escape behavior and motor pattern in the cockroach
    P L Schaefer
    Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106-7080, USA
    J Neurobiol 49:9-28. 2001
    ..Because of the rapidity of the escape response, such effects are likely due to the elimination of tonic descending inputs...
  79. ncbi Giant fiber activation of an intrinsic muscle in the mesothoracic leg of Drosophila melanogaster
    J R Trimarchi
    Section of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853 2702
    J Exp Biol 177:149-67. 1993
    ..To investigate possible presynaptic inputs activating the TLMn during the escape response, we analyzed the muscle responses of two mutants, giant fiber A1 and bendless. Our analysis suggests that the TLMn is activated by a novel pathway...
  80. ncbi The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning
    Robert Ohle
    Department of Physiology, School of Medicine, University of Dublin, Trinity College, Dublin 2, Ireland
    Behav Brain Res 176:362-6. 2007
    ..Spatial learning in the Morris watermaze was unaffected by exercise. These changes were associated with an increase in expression of brain-derived neurotrophic factor in the dentate gyrus...
  81. ncbi Insulin protects against stress-induced impairments in water maze performance
    M Moosavi
    Department of Physiology, School of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Behav Brain Res 176:230-6. 2007
    ..Insulin alone daily injection had no effect on water maze performance. These results suggest that spatial learning and memory is compromised during chronic stress and insulin may protect against this effect...
  82. ncbi The stress experience dependent long-term depression disassociated with stress effect on spatial memory task
    Wenyong Xiong
    Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, Yunnan, China
    Neurosci Res 46:415-21. 2003
    ..Our results showed that SLTD was disassociated with the effect of stress on memory task but might be related to stress experience-dependent form of aberrant memory...
  83. ncbi MHC-congenic mice (C57BL/6J and B6-H-2K) show differences in speed but not accuracy in learning the Hebb-Williams Maze
    Lianne Stanford
    Department of Psychology, Dalhousie University, Halifax, NS, Canada B3H 4J1
    Behav Brain Res 144:187-97. 2003
    ..These results indicate that these two strains show differences in performance in the Hebb-Williams Maze, but do not differ in cognitive ability...
  84. ncbi The influence of landmark salience in a navigation task: an additive effect between its components
    V D Chamizo
    Departament de Psicologia Basica, Universitat de Barcelona, Barcelona, Spain
    J Exp Psychol Anim Behav Process 32:339-44. 2006
    ..The results of Experiment 2 suggested that the different distances from the goal of the 2 landmarks might not be sufficient to explain the previous results...
  85. ncbi Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice
    Alena Lira
    Division of Developmental Psychobiology, Columbia University, New York, New York 10032, USA
    Biol Psychiatry 54:960-71. 2003
    ..Using mice lacking the SERT (SERT KO), we examined the role of SERT function in anxiety- and depression-related behaviors and serotonergic neuron function...
  86. ncbi Spatial learning in male mice with different levels of aggressiveness: effects of housing conditions and nicotine administration
    I Moragrega
    Area de Psicobiologia, Facultad de Psicologia, Universitat de Valencia, Blasco Ibañez, 21, Valencia 46010, Spain
    Behav Brain Res 147:1-8. 2003
    ....
  87. ncbi Infusions of midazolam into the medial prefrontal cortex produce anxiolytic effects in the elevated plus-maze and shock-probe burying tests
    Akeel A Shah
    Department of Psychology, University of Alberta, P217 Biological Sciences Building, T6G 2E9, Edmonton, AB, Canada
    Brain Res 996:31-40. 2004
    ..Furthermore, these anxiolytic effects were found in both the dorsal and ventral regions of the MPFC. The present findings indicate that the benzodiazepine receptors of the MPFC are capable of modulating fear-related behaviors...
  88. ncbi Analysis of the role of the 5-HT1B receptor in spatial and aversive learning in the rat
    Maria Ahlander-Lüttgen
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 28:1642-55. 2003
    ..These results suggest that 5-HT1B receptor antagonists may have a potential in the treatment of cognitive deficits resulting from loss of cholinergic transmission...
  89. ncbi Behavioral alterations induced by HgCl2 depend on the postnatal period of exposure
    Nilce C Peixoto
    Programa de Pos Graduacao em Bioquimica Toxicologica, Universidade Federal de Santa Maria, 97105 900 Santa Maria, RS, Brazil
    Int J Dev Neurosci 25:39-46. 2007
    ..In short, the first days of postnatal life (1st phase) appeared to be more sensitive to mercury exposure than the other phases studied, since they presented behavioral deficits even at a time period somewhat after the exposure...
  90. ncbi Activation of post-synaptic 5-HT(1A) receptors in the dorsal hippocampus prevents learned helplessness development
    Sâmia Regiane Lourenço Joca
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Brain Res 978:177-84. 2003
    ..These data suggest that facilitation of serotonergic neurotransmission in the dorsal hippocampus mediates adaptation to severe inescapable stress, probably through the activation of post-synaptic 5-HT(1A) receptors...
  91. ncbi Different vulnerability in female's spatial behaviour after unilateral hippocampal inactivation
    Jose Manuel Cimadevilla
    Department of Neuroscience, University of Almeria, Carretera de Sacramento s n, 04120 Almeria, Spain
    Neurosci Lett 439:89-93. 2008
    ..This data points to a different role of the hippocampus or a different distribution of memories in both sexes...
  92. ncbi Effects of bilateral vestibular deafferentation on anxiety-related behaviours in Wistar rats
    Yiwen Zheng
    Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand
    Behav Brain Res 193:55-62. 2008
    ..These results suggest that BVD causes changes in the performance of rats in the EPM and ETM that might reflect emotional changes, or could be due to the cognitive impairment and hyperactivity caused by BVD...
  93. ncbi Integrating the open field, elevated plus maze and light/dark box to assess different types of emotional behaviors in one single trial
    Andre Ramos
    Laboratório de Genética do Comportamento, Departamento de Biologia Celular, Embriologia e Genetica, Universidade Federal de Santa Catarina, 88 040 900 Florianópolis, SC, Brazil
    Behav Brain Res 193:277-88. 2008
    ..Together, these results suggest that the new integrated apparatus may contribute to the study of anxiety, by providing a rapid, comprehensive and reliable method of assessing emotionality-related behaviors and its underlying components...
  94. ncbi Effects of BNST lesions in female rats on forced swimming and navigational learning
    Pinar Pezuk
    Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
    Brain Res 1228:199-207. 2008
    ....
  95. ncbi Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio
    Zhifang Dong
    Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, PR China
    Brain Res 1207:164-73. 2008
    ..These findings suggest that delayed-escape behaviour enabled by repeated low-dose morphine treatment may be a useful and simple rat model for studying addictive memories to be retrieved by stress exposure...
  96. ncbi Nitric oxide involvement and neural substrates of the conditioned and innate fear as evaluated in the T-maze test in rats
    A V Calixto
    Department of Pharmacology, CCB, Federal University of Santa Catarina, Florianopolis, SC, Brazil
    Behav Brain Res 189:341-9. 2008
    ..These results are compatible with the proposal that NO exerts a positive modulatory role on defensive reactions in rats, exerting among them an anxiogenic-like effect as evaluated in rats submitted to ETM...
  97. ncbi Cognitive performance of healthy young rats following chronic donepezil administration
    Debora Cutuli
    IRCCS Santa Lucia Foundation, Rome, Italy
    Psychopharmacology (Berl) 197:661-73. 2008
    ..However, few studies have analyzed the effects of chronic donepezil treatment on the cognitive functions of intact animals...
  98. ncbi The effects of overtraining in the Morris water maze on allocentric and egocentric learning strategies in rats
    John Kealy
    Department of Psychology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Behav Brain Res 192:259-63. 2008
    ..Further, with overtraining animals do not always switch from allocentric to an egocentric learning strategy perhaps challenging suggestions of a stored hierarchy of strategies...
  99. ncbi Dorsal hippocampal kindling produces a selective and enduring disruption of hippocampally mediated behavior
    D K Hannesson
    Departments of Psychology and Psychiatry, Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E4
    J Neurosci 21:4443-50. 2001
    ..This preparation may be useful for studying the mechanisms of mnemonic dysfunction associated with temporal lobe epilepsy and may offer unique insights into the mechanisms underlying normal hippocampal function...
  100. ncbi Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents
    Nicholas Jones
    Department of Psychology, University College London, Gower Street, WC1E 6BT, UK
    Psychopharmacology (Berl) 161:314-23. 2002
    ..The sensitivity of the UEEPM to two further putative anxiogenic agents, the benzodiazepine partial inverse agonist FG 7142 and pentylenetetrazole (PTZ), was also assessed...
  101. ncbi 5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze
    Nicholas Jones
    Department of Psychology, University College London, Gower Street, London WC1E 6BT, UK
    Psychopharmacology (Berl) 164:214-20. 2002
    ..This study aimed to examine the involvement of the 5-HT2C receptor in the unconditioned fear responses observed in the UEEPM (after an acute dose of mCPP) by pre-treatment with the selective 5-HT2C receptor antagonist SB-242084...

Research Grants68

  1. AMYGDALOID FUNCTION IN FEAR CONDITIONING
    Stephen Maren; Fiscal Year: 2009
    ..The outcome of these experiments will have an important impact on current conceptions of both amygdaloid function and on clinical disorders of fear that depend on emotional learning and memory. ..
  2. Volatile Anesthetic Action in Vertebrate Locomotor Systems
    Steven L Jinks; Fiscal Year: 2010
    ..Results from these projects will increase our understanding of how and where anesthetics act in the nervous system, contributing to the development of safer anesthetics and clinical practices. ..
  3. PPM-PREP: Peer-Mentored Preparedness for Adults with Developmental Disabilities
    DAVID PAUL EISENMAN; Fiscal Year: 2010
    ..Lessons learned will lend support for rigorously testing this intervention in broader samples. ..
  4. Viral Encephalitis, Chemokines and Sleep
    LARRY D contact SANFORD; Fiscal Year: 2010
    ..Such understanding may provide insight that could lead to improved therapies and improved prognosis for infectious diseases. ..
  5. Fear memory formation in early life
    Christoph Wiedenmayer; Fiscal Year: 2007
    ..A better understanding of fear memory formation in early development is the critical first step in building a translational model of childhood trauma. [unreadable] [unreadable]..
  6. ESCAPE BEHAVIOR--INTEGRATION AND PLASTICITY
    FRANKLIN KRASNE; Fiscal Year: 2005
    ..and electrophysiological methods, we study these processes in a relatively simple system, the lateral giant escape reaction circuit of crayfish, which is subject to a variety of forms of modulation and of simple learning...
  7. ALTERING BEHAVIORAL RISK FOR DRUG DEPENDENCE
    DON CHEREK; Fiscal Year: 2001
    ..Pharmacological effects of these therapeutics drugs on such behavior in a high risk population may provide information relating to alternative strategies in dealing with drug dependence. ..
  8. BEHAVIORAL MECHANISM IN HIGH RISK POPULATIONS
    DON CHEREK; Fiscal Year: 2001
    ..Demonstrating such fundamental differences may lead to different approaches in attempts to modify antisocial behavior among high risk populations with such behavioral tendencies. ..
  9. JWatcher-event recorder and behavioral analysis program
    DANIEL BLUMSTEIN; Fiscal Year: 2004
    ..While we will continue to freely-distribute the software, on-going support and routine updates will be supported by the sales of a detailed users manual, which will include laboratory exercises suitable for teaching. ..
  10. DEVELOPMENTAL EFFECTS OF METHAMPHETAMINE-LIKE STIMULANTS
    Charles Vorhees; Fiscal Year: 2009
    ..The number of prenatally MA exposed children continues to grow. Our goal is to develop models of early MA exposure that permit an understanding of the long-term consequences on brain development and cognition. ..
  11. Effects of Neonatal MDMA on Brain and Behavior
    Charles V Vorhees; Fiscal Year: 2010
    ....
  12. Olfactory Development: Cell Proliferation and Maturation
    CHARLES DERBY; Fiscal Year: 2007
    ..abstract_text> ..
  13. DEVELOPMENTAL EFFECTS OF METHLENEDIOXYMETHAMPHETAMINE
    Charles Vorhees; Fiscal Year: 2002
    ..Such data will help identify risks associated with the prenatal use of MDMA on brain and cognitive development. ..
  14. Antidepressant Effect on Hippocampal Synaptogenesis
    Tibor Hajszan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. ONTOGENY OF STRESS: MOLECULAR AND NEURAL MECHANISMS
    Christoph Wiedenmayer; Fiscal Year: 2004
    ....
  16. 5-HT Modulation of Predator-induced Anxiety in Rats
    RUTH GRAHN; Fiscal Year: 2004
    ..Future studies will build on the goals of the present research by exploring how anxious behavior can be prevented. ..
  17. Central control of rhythmic movement in a vertebrate
    Melina Hale; Fiscal Year: 2006
    ..Such work is critical for understanding the neural basis of movement disruption through injury and disease. [unreadable] [unreadable]..
  18. Contribution of the PAG to morphine tolerance
    Michael Morgan; Fiscal Year: 2002
    ..In the long term, such knowledge should improve the treatment of pain by allowing therapies that disrupt tolerance to be developed. ..
  19. TRANSCRIPTION FACTOR GENES,NEURONAL PLASTICITY AND AGING
    Carol Barnes; Fiscal Year: 2006
    ..The strength of this interaction is the ability to combine and apply the most powerful available methods to test the hypothesis under study, which could not be accomplished in either laboratory in isolation. ..
  20. Associatively-activated event representations
    Peter Holland; Fiscal Year: 2006
    ..The proposed research provides a basis for the understanding of basic processing of imaginal events in associative learning. ..
  21. NeuronBank: A Database for Identified Neurons and Synaptic Connections
    Paul Katz; Fiscal Year: 2007
    ..It is likely to have a high impact on future neuroscience research as it implements a unique neuroinformatics approach to neuron identification and neural circuit analysis. [unreadable] [unreadable]..
  22. Human Laboratory Model of Cocaine Treatment: Behavioral Economic Analysis
    Mark K Greenwald; Fiscal Year: 2010
    ....
  23. New Directions in Migration Modeling
    Joshua Epstein; Fiscal Year: 2008
    ..Agent-based Modeling of migration may assist in this task, and potentially provide public policy leaders an important tool to analyze and possibly test public policy interventions. [unreadable] [unreadable] [unreadable]..
  24. Regulation and function of cGMP in the nervous system
    David B Morton; Fiscal Year: 2011
    ..Viagra and other pharmacological treatments for erectile disfunction are probably just the tip of the iceberg for compounds that target cGMP mediated processes. ..
  25. Neonatal Ethanol-Induced Memory Impairments in Rats
    Pamela Hunt; Fiscal Year: 2009
    ..The potential for amelioration of these cognitive deficits using both behavioral and pharmacological strategies will provide important information regarding treatment approaches for afflicted individuals. ..
  26. NOCICEPTIVE MEMORY: MECHANISMS OF HYPEREXCITABILITY
    EDGAR WALTERS; Fiscal Year: 2009
    ..abstract_text> ..
  27. Ethanol effects on behavior: genes and environment
    Douglas Wahlsten; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  28. Noninvasive monitoring of physiological parameters in mice
    LARRY SANFORD; Fiscal Year: 2008
    ..The proposed applications have particular significance for studies of behavior and sleep. [unreadable] [unreadable] [unreadable]..
  29. Validating microRNA Analysis in Human Postmortem Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. Ca and Na Transport in Heart Failure
    Donald Bers; Fiscal Year: 2008
    ..This should help in developing new therapeutic targets and strategies for the treatment of human HF. ..
  31. Nicotinic Acetylcholine Receptors in Neuropathic Pain
    Michelle Vincler; Fiscal Year: 2008
    ..The results of these studies will further define spinal nicotinic anatomy and functioning in the nerve-injured animal thereby, providing unique potential targets for the pharmacological treatment of neuropathic pain. ..
  32. Affective biasing of attentional processing and control
    JEFFREY MAXWELL; Fiscal Year: 2006
    ..Specifically, this research proposes to examine mechanisms of voluntary inhibition and selective attention under different conditions of emotional arousal, manipulated by incidental variations in threat-evoked anxiety. ..
  33. Estrogen and Cognition Following Ischemia
    NOAH SANDSTROM; Fiscal Year: 2005
    ..abstract_text> ..
  34. CA REGULATION IN INTACT VENTRICULAR MYOCYTES
    Donald Bers; Fiscal Year: 2004
    ..Local calcium transients (calcium sparks and sarcolemmal calcium transients) will be visualized as fluo-3 fluorescence with laser scanning confocal microscopy. ..
  35. POSTRECEPTOR DYSREGULATION IN DEPRESSION
    Yogesh Dwivedi; Fiscal Year: 2004
    ..abstract_text> ..
  36. The influence of social context on early aggression
    Jennifer McComas; Fiscal Year: 2004
    ..Longitudinal studies are needed to determine how early patterns of high-rate aggression in preschool classrooms is influenced by social context. ..
  37. SOCIAL LEARNING AND ALCOHOL INTAKE IN ADOLESCENT RATS
    Pamela Hunt; Fiscal Year: 2004
    ..The end result of this work will be an increased understanding of the neurochemical and behavioral factors underlying social acquisition of ethanol preferences. ..
  38. SYNAPTIC INTEGRATION AND PLASTICITY IN COMMAND NEURONS
    Donald Edwards; Fiscal Year: 2005
    ..This will be studied with standard electrophyiological techniques. ..
  39. PHYLOGENY AND ONTOGENY OF AN AUDITORY SYSTEM
    DAVID YAGER; Fiscal Year: 2004
    ..This line of research will lead to a clearer understanding of the neural and non-neural characteristics that define a hot spot for auditory system evolution. ..
  40. Role of amygdala systems in associative learning
    Peter Holland; Fiscal Year: 2005
    ..abstract_text> ..
  41. NEUROBIOLOGICAL EFFECTS OF ALTERED MOTOR CONTROL IN REM
    LARRY SANFORD; Fiscal Year: 2001
    ..These studies may lead to a better understanding of disorders of REM, such as REM behavior disorder, which, like REM-A, is characterized by overt behavior during sleep. ..
  42. Anatomical Plasticity and HPA Axis Dysfunction
    James Herman; Fiscal Year: 2009
    ..Overall, this project will provide critical new information on hypothalamic mechanisms mediating neuroendocrine dysfunction in affective disease states. ..
  43. Supraspinal Processing of Pain Affect
    PERRY FUCHS; Fiscal Year: 2003
    ..Once established, the overall goal of exploring the limbic system neural circuit related to the selection of competing motivational drives can then be explored. ..
  44. EXPERIENCE AND DECISION-MAKING IN A REAL NEURAL NETWORK
    William Frost; Fiscal Year: 2003
    ..Each aim will employ the combined methodologies of electrophysiology and realistic computer simulations. ..
  45. Exercise and the Aged Brain: Neurotrophins and Stress
    David Albeck; Fiscal Year: 2002
    ..Possible disorders include Parkinson's disease and depression. This project will establish a new and productive research program that will provide increased research opportunities for UCD students. ..
  46. Reducing Cocaine/Heroin Abuse with SR-Amphetamine and Buprenorphine
    Mark Greenwald; Fiscal Year: 2009
    ..The innovative aims, rigorous methods and clinical/public health significance of this project (i.e. whether SR-AMP has potential efficacy for reducing cocaine use) is highly concordant with this RFA. ..
  47. Mathematical Development in Learning Diasbled Children
    DAVID GEARY; Fiscal Year: 2003
    ..g., working memory) that underlie MD children's developmental delays and deficits in these competencies. ..
  48. Tailored Intervention for Melanoma Patients' Families
    Sharon Manne; Fiscal Year: 2008
    ..396 family members will complete the study. Outcomes will be evaluated in terms of TCE, SSE and sun protection habits, as well as changes in attitudes and knowledge about CMM [unreadable] [unreadable]..
  49. SECRETIONS OF ARTHROPODS
    Thomas Eisner; Fiscal Year: 2008
    ..Insects are major vectors of disease. An understanding of how insects depend on natural products for regulation of their biotic interactions is of broad applied significance to both medicine and agriculture. [unreadable] [unreadable]..
  50. Cognitive control deficits in alcoholism risk
    John J Curtin; Fiscal Year: 2010
    ..This will allow mediation tests to determine if predicted alcohol challenge and family history of alcoholism effects on behavior and emotion regulation are the result of impaired attention function. ..
  51. CELL ASSEMBLIES, PATTERN COMPLETION AND THE AGING BRAIN
    Carol Barnes; Fiscal Year: 2003
    ..NMDA receptor antagonists are expected to prevent experience-dependent place field changes in the young rats, and AMPA current enhancers are expected to ameliorate place field properties in the old rats. ..
  52. Signal Transduction Mechanisms in Suicide Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..abstract_text> ..
  53. Glucocorticoid Receptor Mechanisms, Stress and Aging
    James Herman; Fiscal Year: 2006
    ..abstract_text> ..
  54. Genetic Mapping of Functional Neural Networks & Circuits
    Carol Barnes; Fiscal Year: 2006
    ..abstract_text> ..
  55. Amygdala, CREB, and Neuropathic Pain Facilitation
    JENNIFER PETTA; Fiscal Year: 2007
    ..Thus, the experiments in the current proposal investigating the role of the amygdala in chronic pain are timely and may lead to more effective drug targets. [unreadable] [unreadable] [unreadable]..
  56. INTRISIC NEUROMODULATION OF A SMALL NEURONAL NETWORK
    Paul Katz; Fiscal Year: 2006
    ..abstract_text> ..
  57. Biomechanics and the lamprey central pattern generator
    ERIC TYTELL; Fiscal Year: 2008
    ..abstract_text> ..
  58. BOLD fMRI in MR research to map learning histories
    MICHAEL SCHLUND; Fiscal Year: 2004
    ..abstract_text> ..
  59. EFFECTS OF EXCITOTOXIC INJURY ON SPINAL SENSORY PATHWAYS
    Robert Yezierski; Fiscal Year: 2003
    ..abstract_text> ..
  60. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Michael Baratta; Fiscal Year: 2006
    ..abstract_text> ..
  61. Determinants of Reward Value
    REBECCA SINGER; Fiscal Year: 2007
    ..This model is also used to study risk-taking and gambling behavior. [unreadable] [unreadable] [unreadable]..
  62. Approach and Avoidance Motivation and Risky Behavior
    Amy Strachman; Fiscal Year: 2006
    ..abstract_text> ..
  63. Social Anxiety Disorder and Emotion Regulation
    TODD KASHDAN; Fiscal Year: 2007
    ..Findings could ultimately lead to the development of more effective intervention efforts. [unreadable] [unreadable] [unreadable]..
  64. QUALITY OF LIFE IN ADULT CANCER SURVIVORS
    Charles Carver; Fiscal Year: 2002
    ..These people can continue providing important information about the experience of cancer survivorship and what qualities make the process easier or harder. ..
  65. AMYGDALOID FUNCTION IN FEAR CONDITIONING
    Stephen Maren; Fiscal Year: 2002
    ..The outcome of these experiments will have an important impact on current conceptions of both amygdaloid function and emotional learning and memory. ..
  66. NEURAL SUBSTRATE OF OPIATE ANALGESIA
    Howard Fields; Fiscal Year: 2003
    ..Hopefully, by increasing knowledge of what limits the efficacy of opioid analgesia, new pharmacological strategies can be devised to produce more potent and selective analgesics. ..
  67. Induction of Conditional Fear Extinction
    CHRISTOPHER CAIN; Fiscal Year: 2003
    ..Since extinction serves as the explicit model for behavior therapy of anxiety disorders, the findings may provide a foundation for improved psyhotherapies and adjunctive treatments. ..