alcohol drinking

Summary

Summary: Behaviors associated with the ingesting of alcoholic beverages, including social drinking.

Top Publications

  1. ncbi Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
  2. ncbi Diet, lifestyle, and the risk of type 2 diabetes mellitus in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 345:790-7. 2001
  3. pmc Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis
    Paul E Ronksley
    Department of Community Health Sciences, Faculty of Medicine, Calgary Institute for Population and Public Health, University of Calgary, Alberta, Canada
    BMJ 342:d671. 2011
  4. ncbi Alcohol and public health
    Robin Room
    Centre for Social Research on Alcohol and Drugs, Stockholm University, Stockholm, Sweden
    Lancet 365:519-30. 2005
  5. pmc Can simply answering research questions change behaviour? Systematic review and meta analyses of brief alcohol intervention trials
    Jim McCambridge
    Department of Public Health and Policy, Centre for Research on Drugs and Health Behaviour, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 6:e23748. 2011
  6. pmc Combined impact of health behaviours and mortality in men and women: the EPIC-Norfolk prospective population study
    Kay Tee Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    PLoS Med 5:e12. 2008
  7. pmc Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors
    E B Rimm
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    BMJ 319:1523-8. 1999
  8. pmc The relation between different dimensions of alcohol consumption and burden of disease: an overview
    Jurgen Rehm
    Centre for Addiction and Mental Health, Toronto, Canada
    Addiction 105:817-43. 2010
  9. ncbi Actual causes of death in the United States, 2000
    Ali H Mokdad
    Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    JAMA 291:1238-45. 2004
  10. ncbi Effects of beverage alcohol price and tax levels on drinking: a meta-analysis of 1003 estimates from 112 studies
    Alexander C Wagenaar
    University of Florida, College of Medicine, Department of Epidemiology and Health Policy Research, Gainesville, FL 32610 0177, USA
    Addiction 104:179-90. 2009

Detail Information

Publications375 found, 100 shown here

  1. ncbi Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
    Salim Yusuf
    Population Health Research Institute, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2
    Lancet 364:937-52. 2004
    ..Therefore, the effect of such factors on risk of coronary heart disease in most regions of the world is unknown...
  2. ncbi Diet, lifestyle, and the risk of type 2 diabetes mellitus in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 345:790-7. 2001
    ..Previous studies have examined individual dietary and lifestyle factors in relation to type 2 diabetes, but the combined effects of these factors are largely unknown...
  3. pmc Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis
    Paul E Ronksley
    Department of Community Health Sciences, Faculty of Medicine, Calgary Institute for Population and Public Health, University of Calgary, Alberta, Canada
    BMJ 342:d671. 2011
    ..To conduct a comprehensive systematic review and meta-analysis of studies assessing the effect of alcohol consumption on multiple cardiovascular outcomes...
  4. ncbi Alcohol and public health
    Robin Room
    Centre for Social Research on Alcohol and Drugs, Stockholm University, Stockholm, Sweden
    Lancet 365:519-30. 2005
    ....
  5. pmc Can simply answering research questions change behaviour? Systematic review and meta analyses of brief alcohol intervention trials
    Jim McCambridge
    Department of Public Health and Policy, Centre for Research on Drugs and Health Behaviour, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 6:e23748. 2011
    ..The study objective was to evaluate the size and nature of effects observed in randomized manipulations of the effects of answering questions on drinking behaviour in brief intervention trials...
  6. pmc Combined impact of health behaviours and mortality in men and women: the EPIC-Norfolk prospective population study
    Kay Tee Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    PLoS Med 5:e12. 2008
    ..We aimed to quantify the potential combined impact of four health behaviours on mortality in men and women living in the general community...
  7. pmc Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors
    E B Rimm
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    BMJ 319:1523-8. 1999
    ..To summarise quantitatively the association between moderate alcohol intake and biological markers of risk of coronary heart disease and to predict how these changes would lower the risk...
  8. pmc The relation between different dimensions of alcohol consumption and burden of disease: an overview
    Jurgen Rehm
    Centre for Addiction and Mental Health, Toronto, Canada
    Addiction 105:817-43. 2010
    ....
  9. ncbi Actual causes of death in the United States, 2000
    Ali H Mokdad
    Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    JAMA 291:1238-45. 2004
    ..Modifiable behavioral risk factors are leading causes of mortality in the United States. Quantifying these will provide insight into the effects of recent trends and the implications of missed prevention opportunities...
  10. ncbi Effects of beverage alcohol price and tax levels on drinking: a meta-analysis of 1003 estimates from 112 studies
    Alexander C Wagenaar
    University of Florida, College of Medicine, Department of Epidemiology and Health Policy Research, Gainesville, FL 32610 0177, USA
    Addiction 104:179-90. 2009
    ..A total of 112 studies of alcohol tax or price effects were found, containing 1003 estimates of the tax/price-consumption relationship...
  11. pmc Web-based alcohol intervention for Māori university students: double-blind, multi-site randomized controlled trial
    Kypros Kypri
    Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia
    Addiction 108:331-8. 2013
    ..We tested the effectiveness of web-based alcohol screening and brief intervention (e-SBI) for reducing hazardous drinking among Māori university students...
  12. pmc Online alcohol interventions: a systematic review
    Angela White
    Centre for Youth Substance Abuse Research, Faculty of Health Sciences, The University of Queensland, Queensland, Australia
    J Med Internet Res 12:e62. 2010
    ..There has been a significant increase in the availability of online programs for alcohol problems. A systematic review of the research evidence underpinning these programs is timely...
  13. pmc Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats
    Jeffrey A Simms
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California 94608, USA
    Alcohol Clin Exp Res 32:1816-23. 2008
    ..In this study, we have further characterized this drinking model...
  14. ncbi Heavy episodic drinking among Kenyan female sex workers is associated with unsafe sex, sexual violence and sexually transmitted infections
    M F Chersich
    International Centre for Reproductive Health ICRH, Mombasa, Kenya
    Int J STD AIDS 18:764-9. 2007
    ..Interventions are needed to assist female sex workers adopt safer drinking patterns. Investigation is needed for the effectiveness of such interventions in reducing unprotected sex, sexual violence and sexually transmitted infections...
  15. ncbi Alcohol and depression
    Joseph M Boden
    Christchurch Health and Development Study, University of Otago, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Addiction 106:906-14. 2011
    ..To examine the literature on the associations between alcohol use disorders (AUD) and major depression (MD), and to evaluate the evidence for the existence of a causal relationship between the disorders...
  16. ncbi Hazardous alcohol drinking and premature mortality in Russia: a population based case-control study
    David A Leon
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 369:2001-9. 2007
    ..The reason for the low life expectancy in Russian men and large fluctuations in mortality are unknown. We investigated the contribution of alcohol, and hazardous drinking in particular, to male mortality in a typical Russian city...
  17. ncbi Role of oxidative stress in alcohol-induced liver injury
    Arthur I Cederbaum
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Toxicol 83:519-48. 2009
    ..Special emphasis is placed on CYP2E1, which is induced by alcohol and is reactive in metabolizing and activating many hepatotoxins, including ethanol, to reactive products, and in generating ROS...
  18. ncbi Systematic review of effects of low-moderate prenatal alcohol exposure on pregnancy outcome
    J Henderson
    National Perinatal Epidemiology Unit, University of Oxford, Old Road Campus, Oxford, UK
    BJOG 114:243-52. 2007
    ..4 UK units or 83 g/week) compared with consumption of no alcohol on pregnancy outcome...
  19. ncbi A meta-analysis of alcohol consumption and the risk of 15 diseases
    Giovanni Corrao
    Dipartimento di Statistica, Universita di Milano Bicocca, Milan, Italy
    Prev Med 38:613-9. 2004
    ..To compare the strength of evidence provided by the epidemiological literature on the association between alcohol consumption and the risk of 14 major alcohol-related neoplasms and non-neoplastic diseases, plus injuries...
  20. pmc Comparison of two internet-based interventions for problem drinkers: randomized controlled trial
    John Alastair Cunningham
    Social and Epidemiological Research, Centre for Addiction and Mental Health, Toronto, ON, Canada
    J Med Internet Res 14:e107. 2012
    ..Evaluation of Internet-based interventions that contain a variety of research-validated cognitive-behavioral tools, which have been shown to be helpful to those with more severe alcohol concerns, should be a priority...
  21. pmc Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Mia Hashibe
    IARC, Lifestyle, Environment and Cancer Group, Genetics and Epidemiology Cluster, Lyon, France
    Cancer Epidemiol Biomarkers Prev 18:541-50. 2009
    ..The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden...
  22. ncbi Preventing heavy alcohol use in adolescents (PAS): cluster randomized trial of a parent and student intervention offered separately and simultaneously
    Ina M Koning
    Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands
    Addiction 104:1669-78. 2009
    ..To evaluate the effectiveness of two preventive interventions to reduce heavy drinking in first- and second-year high school students...
  23. ncbi The effectiveness of brief alcohol interventions in primary care settings: a systematic review
    Eileen F S Kaner
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Drug Alcohol Rev 28:301-23. 2009
    ..This review aimed to assess the effectiveness of brief interventions in primary care and determine if outcomes differ between efficacy and effectiveness trials...
  24. ncbi Drinking and drinking patterns and health status in the general population of five areas of China
    Wei Hao
    Mental Health Institute, WHO Collaborating Research Center for Abuse and Health, Second Xiangya Hospital of Central South University, Changsha, Hunan, China
    Alcohol Alcohol 39:43-52. 2004
    ..To understand drinking patterns, health status related to drinking and the level of unrecorded alcoholic beverage consumption for the general population living in five areas of China in 2001...
  25. ncbi Integrating person-centered and variable-centered analyses: growth mixture modeling with latent trajectory classes
    B Muthen
    Graduate School of Education and Information Studies, University of California Los Angeles 90095 1521, USA
    Alcohol Clin Exp Res 24:882-91. 2000
    ..In alcohol, drug, and mental health research the recognition of heterogeneity has led to theories of multiple developmental pathways...
  26. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
    ..to be significantly overrepresented and may play an important role in establishing a high level of voluntary alcohol drinking in these mouse models...
  27. ncbi Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice
    Justin S Rhodes
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and VA Medical Center, Portland, Oregon 97239, USA
    Physiol Behav 84:53-63. 2005
    ..We discuss advantages of the model for high-throughput screening assays where the goal is to find other genotypes of mice that drink excessively, or to screen drugs for their efficacy in blocking excessive drinking...
  28. ncbi Clustering of lifestyle risk factors in a general adult population
    A Jantine Schuit
    Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Prev Med 35:219-24. 2002
    ..The objective of the study was to evaluate the degree of clustering of common lifestyle risk factors in a general adult population and to define subgroups with elevated clustering...
  29. pmc Preclinical studies of alcohol binge drinking
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University and VA Medical Center, Portland, Oregon 97239, USA
    Ann N Y Acad Sci 1216:24-40. 2011
    ..Many preclinical models have been employed to study the genetic risks for and biomedical consequences of alcohol drinking. However, these models historically did not result in blood-alcohol concentrations (BACs) exceeding 80 mg%; ..
  30. ncbi Moderate alcohol intake during pregnancy and risk of fetal death
    Anne Marie Nybo Andersen
    Section of Social Medicine, Department of Public Health, University of Copenhagen, Oster Farimagsgade 5, DK 1014 Copenhagen K, Denmark
    Int J Epidemiol 41:405-13. 2012
    ..The aim of this study was to assess the risk of fetal death (spontaneous abortion and stillbirth) according to maternal alcohol consumption in a large Danish pregnancy cohort...
  31. pmc Internet-based brief personalized feedback intervention in a non-treatment-seeking population of adult heavy drinkers: a randomized controlled trial
    Anders Blædel Gottlieb Hansen
    National Institute of Public Health, Faculty of Health Sciences, University of Southern Denmark, Copenhagen, Denmark
    J Med Internet Res 14:e98. 2012
    ..Internet-based interventions for heavy drinkers show promising results, but existing research is characterized by few studies in nonstudent adult populations and few comparisons with appropriate control groups...
  32. pmc Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis
    Albert E Chudley
    Children s Hospital, Health Sciences Centre, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Man
    CMAJ 172:S1-S21. 2005
    ..These are the first Canadian guidelines for the diagnosis of FAS and its related disabilities, developed by broad-based consultation among experts in diagnosis...
  33. pmc A randomized controlled trial of an internet-based intervention for alcohol abusers
    John A Cunningham
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Addiction 104:2023-32. 2009
    ..The objective of this project is to conduct a randomized controlled evaluation of the internet-based Check Your Drinking (CYD) screener ( http://www.CheckYourDrinking.net)...
  34. ncbi The effectiveness of web-based interventions designed to decrease alcohol consumption--a systematic review
    Bridgette M Bewick
    Leeds Institute of Health Sciences, University of Leeds, Leeds, UK
    Prev Med 47:17-26. 2008
    ..To review the published literature on the effectiveness of web-based interventions designed to decrease consumption of alcohol and/or prevent alcohol abuse...
  35. ncbi Intimate partner violence: causes and prevention
    Rachel Jewkes
    Gender and Health Group, Medical Research Council, Private Bag X385, 0001, Pretoria, South Africa
    Lancet 359:1423-9. 2002
    ..Primary preventive interventions should focus on improving the status of women and reducing norms of violence, poverty, and alcohol consumption...
  36. ncbi AUDIT-C as a brief screen for alcohol misuse in primary care
    Katharine A Bradley
    Health Services Research and Development, VA Puget Sound Health Care System, Seattle, WA 98101, USA
    Alcohol Clin Exp Res 31:1208-17. 2007
    ..However, the AUDIT-C's validity and optimal screening threshold(s) in other clinical populations are unknown...
  37. pmc Mental health and HIV sexual risk behavior among patrons of alcohol serving venues in Cape Town, South Africa
    Kathleen J Sikkema
    Department of Psychology and Neuroscience, Duke University, Durham, NC, USA
    J Acquir Immune Defic Syndr 57:230-7. 2011
    ..Understanding the association between mental health and risk behaviors in these settings may inform interventions that address alcohol use and HIV prevention...
  38. pmc The spread of alcohol consumption behavior in a large social network
    J Niels Rosenquist
    Massachusetts General Hospital, Harvard Medical School, and Boston University School of Medicine, 180 A Longwood Avenue, Boston, MA 02115, USA
    Ann Intern Med 152:426-33, W141. 2010
    ..Alcohol consumption has important health-related consequences and numerous biological and social determinants...
  39. ncbi Cost-effectiveness of interventions to prevent alcohol-related disease and injury in Australia
    Linda Cobiac
    School of Population Health, The University of Queensland, Queensland, Australia
    Addiction 104:1646-55. 2009
    ..To evaluate cost-effectiveness of eight interventions for reducing alcohol-attributable harm and determine the optimal intervention mix...
  40. ncbi Alcohol and cancer
    Paolo Boffetta
    International Agency for Research on Cancer, Lyon, France
    Lancet Oncol 7:149-56. 2006
    ..Alcohol consumption is increasing in many countries and is an important cause of cancer worldwide...
  41. ncbi Liver cirrhosis mortality rates in Britain from 1950 to 2002: an analysis of routine data
    David A Leon
    Non communicable Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 367:52-6. 2006
    ..Total recorded alcohol consumption in Britain doubled between 1960 and 2002, giving rise to a need to examine and assess cirrhosis mortality trends...
  42. pmc Substance use and its predictors among undergraduate medical students of Addis Ababa University in Ethiopia
    Wakgari Deressa
    Department of Epidemiology and Biostatistics, School of Public Health, College of Health Sciences, Addis Ababa University, Ethiopia
    BMC Public Health 11:660. 2011
    ..This study was conducted to determine the prevalence of substance use and identify factors that influenced the behavior among undergraduate medical students of Addis Ababa University in Ethiopia...
  43. ncbi Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis
    Yin Ju Chen
    Graduate Institute of Biomedical Science, Chang Gung University, 259 Wen hwa 1 Road, Taoyuan 333, Taiwan
    Cancer Sci 99:1507-14. 2008
    ..Environmental carcinogens such as betel quid chewing, tobacco smoking and alcohol drinking have been identified as major risk factors for head and neck cancer...
  44. ncbi Why do young people drink? A review of drinking motives
    Emmanuel Kuntsche
    Research Department, Swiss Institute for the Prevention of Alcohol and Drug Problems SIPA, PO Box 870, 1001 Lausanne, Switzerland
    Clin Psychol Rev 25:841-61. 2005
    ..Future studies should therefore use well-defined, theoretically based, homogenous instruments to disentangle cultural from measurement differences across surveys...
  45. ncbi Drinking at European universities? A review of students' alcohol use
    Matthias Wicki
    Swiss Institute for the Prevention of Alcohol and Drug Problems SIPA, Research Department, PO Box 870, CH 1001 Lausanne, Switzerland
    Addict Behav 35:913-24. 2010
    ..The vast majority of these studies are based on US and Canadian samples...
  46. ncbi The association between alcohol and reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma
    Lesley A Anderson
    Centre for Public Health, Queen s University, Belfast, Northern Ireland
    Gastroenterology 136:799-805. 2009
    ..However, reports about the association between alcohol and reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma are conflicting...
  47. ncbi Randomized controlled trial of proactive web-based alcohol screening and brief intervention for university students
    Kypros Kypri
    School of Medicine and Public Health, David Maddison Clinical Sciences Bldg, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Arch Intern Med 169:1508-14. 2009
    ..We tested the efficacy of a proactive Web-based alcohol screening and brief intervention program...
  48. pmc Normative misperceptions and temporal precedence of perceived norms and drinking
    Clayton Neighbors
    Department of Psychiatry and Behavioral Sciences, University of Washington, Box 356560, Seattle, Washington 98195 6560, USA
    J Stud Alcohol 67:290-9. 2006
    ..The present research was designed to evaluate (1) the stability of normative misperceptions and (2) temporal precedence of perceived norms and drinking...
  49. ncbi Age of drinking onset and unintentional injury involvement after drinking
    R W Hingson
    Department of Social and Behavioral Sciences, Boston University School of Public Health, MA 02118, USA
    JAMA 284:1527-33. 2000
    ..Onset of drinking at an early age has been found to be associated with alcohol dependence, but whether early-onset drinking increases risk for unintentional injury while drinking is unknown...
  50. pmc Effectiveness of a web-based intervention for problem drinkers and reasons for dropout: randomized controlled trial
    Marloes G Postel
    Nijmegen Institute for Scientist Practitioners in Addiction, Nijmegen, Netherlands
    J Med Internet Res 12:e68. 2010
    ..Online self-help interventions for problem drinkers show promising results, but the effectiveness of online therapy with active involvement of a therapist via the Internet only has not been examined...
  51. ncbi Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    Mia Hashibe
    Gene Environment Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
    J Natl Cancer Inst 99:777-89. 2007
    At least 75% of head and neck cancers are attributable to a combination of cigarette smoking and alcohol drinking. A precise understanding of the independent association of each of these factors in the absence of the other with the risk ..
  52. ncbi Is there an association between alcohol consumption and sexually transmitted diseases? A systematic review
    Robert L Cook
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Sex Transm Dis 32:156-64. 2005
    ..The objective of this study was to conduct a systematic review of published literature on the association between problematic alcohol consumption and sexually transmitted diseases (STDs)...
  53. ncbi Curbing problem drinking with personalized-feedback interventions: a meta-analysis
    Heleen Riper
    Innovation Centre of Mental Health and Technology, Trimbos Institute Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands
    Am J Prev Med 36:247-55. 2009
    ..A meta-analysis was performed to examine the overall effectiveness of brief, single-session personalized-feedback interventions without therapeutic guidance...
  54. ncbi Alcohol, oxidative stress and free radical damage
    Emanuele Albano
    Department of Medical Sciences, University of A Avogadro East Piedmont, Novara, Italy
    Proc Nutr Soc 65:278-90. 2006
    ..Together these observations provide a rationale for the possible clinical application of antioxidants in the therapy for ALD...
  55. ncbi Clustering of risk behaviors with cigarette consumption: A population-based survey
    Arnaud Chiolero
    Prevention Unit, University Institute of Social and Preventive Medicine, 17, Rue du Bugnon, 1005 Lausanne, Switzerland
    Prev Med 42:348-53. 2006
    ..This study assessed clustering of multiple risk behaviors (i.e., low leisure-time physical activity, low fruits/vegetables intake, and high alcohol consumption) with level of cigarette consumption...
  56. ncbi Alcohol consumption and the metabolic syndrome in Korean adults: the 1998 Korean National Health and Nutrition Examination Survey
    Yeong Sook Yoon
    Department of Family Medicine, Ilsan Paik Hospital, University of Inje, College of Medicine, Goyang City, Gyunggi Do, Korea
    Am J Clin Nutr 80:217-24. 2004
    ..The metabolic syndrome is associated with a high risk of cardiovascular disease morbidity and mortality. Light and moderate alcohol consumption have been associated with reduced cardiovascular disease morbidity and mortality...
  57. pmc Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
    Gunter Schumann
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London SE5 8AF, United Kingdom
    Proc Natl Acad Sci U S A 108:7119-24. 2011
    ..001). Our finding of a regulator of alcohol consumption adds knowledge to our understanding of genetic mechanisms influencing alcohol drinking behavior.
  58. ncbi Effects of alcohol reduction on blood pressure: a meta-analysis of randomized controlled trials
    X Xin
    Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA
    Hypertension 38:1112-7. 2001
    b>Alcohol drinking has been associated with increased blood pressure in epidemiological studies. We conducted a meta-analysis of randomized controlled trials to assess the effects of alcohol reduction on blood pressure...
  59. ncbi Under-reporting of alcohol consumption in household surveys: a comparison of quantity-frequency, graduated-frequency and recent recall
    Tim Stockwell
    National Drug Research Institute, Perth, Australia
    Addiction 99:1024-33. 2004
    ..To compare alternative survey methods for estimating (a) levels of at risk alcohol consumption and (b) total volume of alcohol consumed per capita in comparison with estimates from sales data and to investigate reasons for under-reporting...
  60. ncbi Economic costs of excessive alcohol consumption in the U.S., 2006
    Ellen E Bouchery
    Mathematica Policy Research, Washington, DC, USA
    Am J Prev Med 41:516-24. 2011
    ..However, its economic cost has not been assessed for the U.S. since 1998...
  61. ncbi Estimated effect of alcohol pricing policies on health and health economic outcomes in England: an epidemiological model
    Robin C Purshouse
    Department of Automatic Control and Systems Engineering, University of Sheffield, Sheffield, UK
    Lancet 375:1355-64. 2010
    ..We assessed effects of alcohol pricing and promotion policy options in various population subgroups...
  62. ncbi Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus
    Manal M Hassan
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Hepatology 36:1206-13. 2002
    ..Exploring the underlying mechanisms for such synergisms may indicate new HCC prevention strategies in high-risk individuals...
  63. ncbi Can stand-alone computer-based interventions reduce alcohol consumption? A systematic review
    Zarnie Khadjesari
    e Health Unit, Research Department of Primary Care and Population Health, University College London, Royal Free Hospital, London, UK
    Addiction 106:267-82. 2011
    ..To determine the effects of computer-based interventions aimed at reducing alcohol consumption in adult populations...
  64. ncbi Global alcohol exposure estimates by country, territory and region for 2005--a contribution to the Comparative Risk Assessment for the 2010 Global Burden of Disease Study
    Kevin D Shield
    Centre for Addiction and Mental Health, Toronto, ON, Canada Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Addiction 108:912-22. 2013
    ....
  65. pmc Alcohol as a risk factor for type 2 diabetes: A systematic review and meta-analysis
    Dolly O Baliunas
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Diabetes Care 32:2123-32. 2009
    ..To clarify the dose-response relationship between alcohol consumption and type 2 diabetes...
  66. ncbi Regular use of alcohol and tobacco in India and its association with age, gender, and poverty
    K J Neufeld
    Johns Hopkins University School of Medicine, Department of Psychiatry, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Drug Alcohol Depend 77:283-91. 2005
    ..Comparisons are made between these results and those found in the United States and elsewhere, highlighting the need to address control of these substances on the public health agenda...
  67. pmc Alcohol use and antiretroviral adherence: review and meta-analysis
    Christian S Hendershot
    Department of Psychology, University of Washington, Seattle, WA 98195, USA
    J Acquir Immune Defic Syndr 52:180-202. 2009
    ..This meta-analysis provides a quantitative evaluation of the alcohol-adherence association by aggregating findings across studies and examining potential moderators...
  68. ncbi Global burden of disease from alcohol, illicit drugs and tobacco
    Jurgen Rehm
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Drug Alcohol Rev 25:503-13. 2006
    ..The burden of disease attributable to the use of legal substances clearly outweighed the use of illegal drugs. A large part of the substance-attributable burden would be avoidable if known effective interventions were implemented...
  69. ncbi Influence of individual and combined health behaviors on total and cause-specific mortality in men and women: the United Kingdom health and lifestyle survey
    Elisabeth Kvaavik
    Department of Nutrition, University of Oslo, PO Box 1046 Blindern, N 0316 Oslo, Norway
    Arch Intern Med 170:711-8. 2010
    ..Physical activity, diet, smoking, and alcohol consumption have been shown to be related to mortality. We examined prospectively the individual and combined influence of these risk factors on total and cause-specific mortality...
  70. ncbi The effect of different alcohol drinking patterns in early to mid pregnancy on the child's intelligence, attention, and executive function
    U S Kesmodel
    Department of Public Health, Section of Epidemiology, Aarhus University, Aarhus, Denmark
    BJOG 119:1180-90. 2012
    ..To conduct a combined analysis of the estimated effects of maternal average weekly alcohol consumption, and any binge drinking, in early to mid pregnancy on general intelligence, attention, and executive function in 5-year-old children...
  71. pmc Brief intervention for heavy-drinking college students: 4-year follow-up and natural history
    J S Baer
    Center of Excellence in Substance Abuse Treatment and Education, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Am J Public Health 91:1310-6. 2001
    ..This study examined long-term response to an individual preventive intervention for high-risk college drinkers relative to the natural history of college drinking...
  72. ncbi The prevalence and etiology of elevated aminotransferase levels in the United States
    Jeanne M Clark
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Gastroenterol 98:960-7. 2003
    ..Unexplained aminotransferase elevation was strongly associated with adiposity and other features of the metabolic syndrome, and thus may represent nonalcoholic fatty liver disease...
  73. ncbi Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma
    Jorge A Marrero
    Division of Gastroenterology, University of Michigan, 3912 Taubman Center, Ann Arbor, MI 48109 0362, USA
    J Hepatol 42:218-24. 2005
    ..The role of tobacco as a risk factor for HCC is controversial. Recently, obesity has been reported to be a risk factor for HCC. We investigated whether these factors increase the risk of HCC in American patients...
  74. ncbi Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma
    Debra Ting Hsiung
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:108-14. 2007
    ..This study aimed to determine whether global methylation in DNA derived from whole blood, a proxy tissue, is associated with HNSCC and to assess potential modification of this property by environmental or behavioral risk factors...
  75. ncbi The prevalence and clustering of four major lifestyle risk factors in an English adult population
    Wouter Poortinga
    Cardiff University, UK
    Prev Med 44:124-8. 2007
    ....
  76. ncbi Drinking behaviour among men and women in China: the 2007 China Chronic Disease and Risk Factor Surveillance
    Yichong Li
    National Center for Chronic and Non communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
    Addiction 106:1946-56. 2011
    ..To obtain information on drinking behaviour and to examine the associations between frequency of drinking, usual daily drinking quantity and binge drinking behaviour among Chinese residents aged 15-69 years...
  77. pmc The relationship between neighborhood poverty and alcohol use: estimation by marginal structural models
    Magdalena Cerda
    Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York, NY 10029, USA
    Epidemiology 21:482-9. 2010
    ....
  78. ncbi Alcohol use among Swedes and a psychometric evaluation of the alcohol use disorders identification test
    Hans Bergman
    Department of Clinical Neuroscience, Karolinska Institute and Addiction Center North at Magnus Huss Clinic, Karolinska Hospital, Stockholm, Sweden
    Alcohol Alcohol 37:245-51. 2002
    ..Both the internal and test- retest reliability of the Swedish version of AUDIT were satisfactory. A table for converting raw scores to non-normalized T-scores for each combination of gender and three age intervals is presented...
  79. ncbi Accuracy of self-reported drinking: observational verification of 'last occasion' drink estimates of young adults
    Jeremy Northcote
    School of Social Sciences and Humanities, Faculty of Arts, Education and Creative Media, Murdoch University, South Street, Murdoch, WA, USA
    Alcohol Alcohol 46:709-13. 2011
    ..This study is the first known attempt to validate the accuracy of self-reported alcohol consumption using data from a natural setting...
  80. ncbi Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk
    Ri Cui
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Gastroenterology 137:1768-75. 2009
    ..Therefore, identification of epidemiologic factors that influence the development of ESCC would facilitate prevention and/or early detection of the disease...
  81. pmc Alcohol consumption in relation to aberrant DNA methylation in breast tumors
    Meng Hua Tao
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA
    Alcohol 45:689-99. 2011
    ....
  82. ncbi Alcohol intake, smoking, sleeping hours, physical activity and the metabolic syndrome
    A C Santos
    Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal
    Prev Med 44:328-34. 2007
    ..To evaluate the association between physical activity, sleeping hours, alcohol intake and smoking and metabolic syndrome...
  83. pmc Impact and costs of incentives to reduce attrition in online trials: two randomized controlled trials
    Zarnie Khadjesari
    e Health Unit, Research Department of Primary Care and Population Health, University College London, London, United Kingdom
    J Med Internet Res 13:e26. 2011
    ....
  84. ncbi Alcohol consumption and mortality from all-cause and cancers among 1.34 million Koreans: the results from the Korea national health insurance corporation's health examinee cohort in 2000
    Mi Kyung Kim
    Department of Preventive Medicine, Hanyang University, College of Medicine, Medical School Building A, Room 512, 17 Haengdang dong, Sungdong gu, Seoul 133 791, Republic of Korea
    Cancer Causes Control 21:2295-302. 2010
    ..The relationship between alcohol and cancer death has not been well established in Asian population, particularly among women...
  85. ncbi Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use
    Dorothea Blomeyer
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 63:146-51. 2008
    ..The aim of this study was to examine interactions between two haplotype-tagging single nucleotide polymorphisms (SNPs) covering the CRHR1 gene and adverse life events on heavy drinking in adolescents...
  86. ncbi Meeting recommendations for multiple healthy lifestyle factors. Prevalence, clustering, and predictors among adolescent, adult, and senior health plan members
    Nicolaas P Pronk
    Center for Health Promotion, HealthPartners Research Foundation, HealthPartners, Minneapolis, Minnesota, USA
    Am J Prev Med 27:25-33. 2004
    ..Such data may guide both clinical and health policy decision making and person-centered approaches to population health improvement...
  87. pmc Prevalence of substance use among college students in Eldoret, western Kenya
    Lukoye Atwoli
    Department of Mental Health, Moi University School of Medicine, PO Box 4606, Eldoret 30100, Kenya
    BMC Psychiatry 11:34. 2011
    ..This study therefore aimed to establish the prevalence and factors associated with drug use among university and college students in a low income country...
  88. ncbi Alcohol use and intimate relationships in adolescence: when love comes to town
    R C Engels
    Department of Childhood and Adolescence, Utrecht University, The Netherlands
    Addict Behav 25:435-9. 2000
    ..For females, the differences in changes in consumption between the partnership categories were in most cases not significant...
  89. ncbi Binge drinking and associated health risk behaviors among high school students
    Jacqueline W Miller
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop K 55, Atlanta, GA 30341, USA
    Pediatrics 119:76-85. 2007
    ....
  90. pmc Interactions of the apolipoprotein C-III 3238C>G polymorphism and alcohol consumption on serum triglyceride levels
    Yin Ruixing
    Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, 22 Shuangyong Road, Nanning 530021, Guangxi, People s Republic of China
    Lipids Health Dis 9:86. 2010
    ..The present study was undertaken to detect the interactions of the ApoC-III 3238C>G (rs5128) polymorphism and alcohol consumption on serum TG levels...
  91. pmc Longitudinal patterns and predictors of alcohol consumption in the United States
    Alison A Moore
    David Geffen School of Medicine at UCLA, Division of Geriatrics, 10945 Le Conte Ave, Suite 2339, Los Angeles, CA 90095 1687, USA
    Am J Public Health 95:458-65. 2005
    ..We examined demographic predictors of longitudinal patterns in alcohol consumption...
  92. pmc Cohort profile: the GAZEL Cohort Study
    Marcel Goldberg
    INSERM Unité 687, 14 rue du Val d Osne, 99410 Saint Maurice, France
    Int J Epidemiol 36:32-9. 2007
  93. ncbi A population-based estimate of the prevalence of behavioral risk factors among adult cancer survivors and noncancer controls
    Elliot J Coups
    Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Prev Med 40:702-11. 2005
    ..Behavioral risk factors have significant biomedical and psychosocial effects for cancer survivors. Representative data on the prevalence of a wide range of behavioral risk factors among cancer survivors are lacking...
  94. ncbi Randomized controlled trial of the effects of completing the Alcohol Use Disorders Identification Test questionnaire on self-reported hazardous drinking
    Jim McCambridge
    Centre for Research on Drugs and Health Behaviour, Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
    Addiction 103:241-8. 2008
    ..The direct effects of screening on drinking behaviour have not previously been evaluated experimentally. We tested whether screening reduces self-reported hazardous drinking in comparison with a non-screened control group...
  95. ncbi The validity of self-reports of alcohol consumption: state of the science and challenges for research
    Frances K Del Boca
    Department of Psychology, University of South Florida, Florida, USA
    Addiction 98:1-12. 2003
    ....
  96. ncbi Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    N Engl J Med 348:109-18. 2003
    ..Although moderate drinking confers a decreased risk of myocardial infarction, the roles of the drinking pattern and type of beverage remain unclear...
  97. ncbi Alcohol as a risk factor for global burden of disease
    Jurgen Rehm
    Addiction Research Institute, Zurich, Switzerland
    Eur Addict Res 9:157-64. 2003
    ..To make quantitative estimates of the burden of disease attributable to alcohol in the year 2000 on a global basis...
  98. ncbi Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Addict Biol 17:452-64. 2012
    ..This investigation suggests that ghrelin is potentially able to affect alcohol-seeking behaviors, such as alcohol drinking and craving, representing a new potential neuropharmacological target for AD.
  99. ncbi Web-based self-help for problem drinkers: a pragmatic randomized trial
    Heleen Riper
    Trimbos Institute, Utrecht, The Netherlands
    Addiction 103:218-27. 2008
    ..Self-help interventions for adult problem drinkers in the general population have proved effective. The question is whether this also holds for self-help interventions delivered over the internet...
  100. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
    ..The absence of study-wide significant effects on AD results from the low P-value required when testing multiple single nucleotide polymorphisms and phenotypes...
  101. pmc Providing web-based feedback and social norms information to reduce student alcohol intake: a multisite investigation
    Bridgette M Bewick
    Academic Unit of Psychiatry and Behavioural Sciences, Leeds Institute of Health Sciences, University of Leeds, Leeds, United Kingdom
    J Med Internet Res 12:e59. 2010
    ..Further evidence is needed of the effectiveness of Internet-delivered interventions and of their generalizability across educational institutions...

Research Grants69

  1. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2013
    ..Thus, alcohol tolerance can thereby promote increased alcohol drinking and maintain alcohol addictive behaviors...
  2. DNA Methylation in Ethanol Drinking Behavior
    David P Gavin; Fiscal Year: 2013
    ..Ultimately, these studies will identify novel molecular targets in the actions of ethanol and ethanol drinking behavior, and promote the development of pharmacotherapy for alcoholism. ..
  3. Signaling Mechanisms in Alcohol Drinking Behaviors
    Subhash C Pandey; Fiscal Year: 2013
    ....
  4. Role of AIE in Epigenetic and Behavioral Changes at Adulthood
    Subhash C Pandey; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Binge alcohol drinking occurs at a high rate among adolescents, which can lead to anxiety and alcohol abuse disorders during ..
  5. Dissecting the Role of Unfolded Protein Response in Alcoholic Liver Disease
    Ling Qi; Fiscal Year: 2013
    ..IRE11-XBP1 branch of UPR directly regulates the lipogenic program in the liver in response to chronic-binge alcohol drinking, thereby playing a key role in the pathogenesis of alcoholic fatty liver disease...
  6. Effect of Baclofen on Alcohol Cue-Elicited Urges to Drink and Smoke
    GEORGE ANTHONY KENNA; Fiscal Year: 2011
    ..Currently, there are no approved medications able to reduce both alcohol drinking and smoking in individuals with alcohol and nicotine co-dependencies...
  7. Head and Neck Cancer Risk Prediction Model
    Yuan Chin Amy Lee; Fiscal Year: 2013
    ..The risk factors under investigation will include tobacco smoking, alcohol drinking, family history of HNC, HPV infection, select genetic variants, involuntary smoking, sexual behaviors, oral ..
  8. Neurochemical &Behavioral Correlates of ETOH Effects
    Rueben A Gonzales; Fiscal Year: 2013
    ..Training in psychosocial aspects of alcohol research (Fromme) and the interaction of genotype and effects of alcohol drinking in humans (Fromme, Harris) will also be done...
  9. Personalized Treatment with Pharmacotherapy and CBT for Moderate Problem Drinking
    Andrew C Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Problematic alcohol drinking (the extreme form of which is alcohol dependence) is an etiologically and clinically heterogeneous phenomenon that is most likely caused by an interaction of genetic ..
  10. Gene-environment interaction: the brain CRF system in alcohol preferring msP rats
    Marisa Roberto; Fiscal Year: 2013
    ..that will be critical to understanding the link between genetically determined vulnerability to excessive alcohol drinking, innate hypersensitivity to stress and ethanol-induced neuroadaptation of the brain stress system...
  11. Early binge drinking and gene regulation
    Howard J Edenberg; Fiscal Year: 2013
    ..to heavy exposure to alcohol in a binge drinking paradigm, contribute to the development of excessive alcohol drinking. We hypothesize that alcohol exposure will affect DNA methylation which will have lasting effects on gene ..
  12. Molecular mechanism of ADNF and ADNP peptides in prevention of mitochondrial dysf
    Youssef Sari; Fiscal Year: 2010
    ..established liquid diet mixed with alcohol in a model of fetal alcohol exposure (FAE) that mimics moderate alcohol drinking. Because the molecular mechanisms of action of both SAL and NAP in protecting mitochondria against alcohol ..
  13. Molecular mechanisms of excessive alcohol consumption and relapse-like behavior
    REGINALD DEVON CANNADY; Fiscal Year: 2012
    The behavioral and molecular mechanisms underlying excessive alcohol drinking behavior and relapse are not fully understood and are vital for mapping the pathological course of alcoholism/dependence...
  14. Ethanol, Lung Mesenchymal Stem Cells and Pulmonary Inflammation After Burn Injury
    JILL ANN IPPOLITO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Binge alcohol drinking is practiced by an estimated 38 million adults in the United States and factors into more than 50 different injuries or diseases including burn injury...
  15. Dependence Induced Changes in Ethanol Reinforcement
    Christopher L Cunningham; Fiscal Year: 2013
    ..mechanisms involved in dependence-enhanced alcohol intake in mouse lines selectively bred for differences in alcohol drinking preference (HAP3/LAP3) or alcohol withdrawal severity (WSP/WSR) by testing the hypothesis that common genes ..
  16. Paternal preconception alcohol on epigenetics and offspring drinking
    Andrey Finegersh; Fiscal Year: 2013
    ..Our proposal presents a novel approach to study transmission of alcohol drinking behaviors that contribute to risk for AUDs...
  17. Anxiety and Alcohol Drinking in a Genetic Animal Model of Alcoholism
    JULIA ANN CHESTER; Fiscal Year: 2010
    ..by examining the relationship between susceptibility toward learned fear/anxiety and innate propensity toward alcohol drinking behavior in mouse lines that have been selectively bred for high (HAP1 and HAP2) or low (LAP1 and LAP2) ..
  18. CRF regulation of BNST target control in alcohol withdrawal
    Yuval Silberman; Fiscal Year: 2012
    ..disease hypothesized to develop due a transition in the neurocircuitry responsible for initial excessive alcohol drinking and latter dependency...
  19. The impact of HPA axis dysregulation on the interoceptive effects of alcohol
    Joyce Besheer; Fiscal Year: 2013
    ..Impaired HPA axis function is also evident in populations that are at risk for increased alcohol drinking such as nonalcoholic individuals with a family history of alcoholism, and individuals suffering from some ..
  20. Neuropeptide Y: Role in ethanol intake and sensitivity
    Todd E Thiele; Fiscal Year: 2013
    ..However, heavy alcohol use and binge alcohol drinking by non-dependent individuals have received far less attention...
  21. Excessive Alcohol Drinking Associated with GABA Alpha 2-Regulated TLR4 Expression
    Adam C Puche; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Excessive alcohol drinking is an enormous public health burden in need of more radical therapy...
  22. Alcoholism and Schizophrenia: A Translational Approach to Treatment
    Alan I Green; Fiscal Year: 2012
    ..dopamine D2 receptor and the norepinephrine a2 receptor, which by itself has a minimal ability to decrease alcohol drinking in patients with SCZ or in alcohol-preferring rodents, will decrease alcohol drinking in rodents when ..
  23. Histone modifications in transcriptional regulation by alcohol dependence
    Pietro P Sanna; Fiscal Year: 2013
    ..level of the G protein beta 1 subunit (0(31), which was identified by the INIA consortium as a regulator of alcohol drinking that can directly regulate chromatin dynamics...
  24. Phosphodiesterease-4 (PDE4) as a Novel Target to Reduce Ethanol Consumption
    Han Ting Zhang; Fiscal Year: 2012
    ..a prototypical inhibitor of PDE4, on ethanol consumption in well recognized animal models of excessive alcohol drinking, including C57BL/6J mice and high alcohol-preferring mice (HAP2 and HAP3 lines)...
  25. UNC-CH NADIA Administrative Core
    Fulton T Crews; Fiscal Year: 2013
    ..motivation, social functioning, decision-making cognitive assessments, impulsivity, circadian rhythms, and alcohol drinking behaviors using AIE...
  26. Microglial activation in alcohol dependence: A [C-11]PBR28 PET study.
    Kelly P Cosgrove; Fiscal Year: 2013
    ..Rodent and postmortem human studies suggest this activation is a consequence of chronic alcohol drinking and that it is persistent...
  27. Impulsivity and reward in adult rats exposed to alcohol during adolescence
    Athina Markou; Fiscal Year: 2013
    ..of the reward system in the adolescent brain, a system whose functioning may be altered by excessive alcohol drinking in adolescence...
  28. Stress and alcohol drinking: early life dysregulation of neuropeptides
    LARA STEPHANIE HWA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The link between stress and alcohol drinking is complex, but some crucial neuroadaptations in stress pathways are beginning to be understood...
  29. The effect of alcohol drinking on NPY modulation of inhibition in the BNST
    KRISTEN ELIZABETH PLEIL; Fiscal Year: 2013
    ..Repeated cycles of withdrawal after binge alcohol drinking may cause persistent adaptations in brain regions that regulate alcohol drinking and anxiety-related ..
  30. Indiana Gene Array Core
    Howard J Edenberg; Fiscal Year: 2010
    ..to alcohol or its withdrawal (gene-environment interactions) contribute to the development of excessive alcohol drinking. The Indiana Gene Array Core will focus on the use of Affymetrix microarrays to measure gene expression in ..
  31. Center for Neuroregulation in Alcohol Dependence (CeNiAD)
    Andrew J Saxon; Fiscal Year: 2010
    ..observation that the CNS active generic CM adrenoreceptor (AR) antagonist prazosin reduced or eliminated alcohol drinking in veterans with posttraumatic stress disorder (PTSD) and comorbid alcohol dependence...
  32. Preclinical Assessment of Medications for Alcohol Abuse
    Elise M Weerts; Fiscal Year: 2011
    ..behavioral efficacy of compounds that target receptor mechanisms believed to be influential in maintaining alcohol drinking and alcohol- seeking behaviors that are relevant to compulsive alcohol use and relapse in humans...
  33. CNS SITES MEDIATING ALCOHOL DRINKING BEHAVIOR
    James M Murphy; Fiscal Year: 2010
    ..provided by applicant): The objectives of this research are to investigate dopamine (DA) regulation of alcohol drinking behavior within central nervous system (CMS) sites of the mesocorticolimbic DA system that are thought to ..
  34. Negative Affect, Urges and Distress Tolerance, Effects on Cognition in AUDs
    Travis Cook; Fiscal Year: 2013
    ..Relapse to alcohol drinking following alcohol treatment often occurs when an individual feels strong negative emotions such as sadness, ..
  35. Ghrelin antogonism and excessive drinking
    Andrey E Ryabinin; Fiscal Year: 2013
    ..by US indicate that the ghrelin antagonist D-Lys3-GHRP-6 (DLys) strongly and preferentially decreases alcohol drinking in the mouse "drinking-in-the-dark" (DID) model of binge-like excessive alcohol consumption, and that this ..
  36. Habits and cues in alcohol drinking: Dynamic striatal activity
    Donita L Robinson; Fiscal Year: 2012
    ..The learning processes underlying habit formation may contribute to continued alcohol drinking and render the behavior resistant to change...
  37. Noradrenergic Agents As Potential New Pharmacotherapies for Alcohol Drinking
    Dennis D Rasmussen; Fiscal Year: 2013
    ..be done to determine the most effective way to use prazosin and to determine how prazosin works to decrease alcohol drinking. Accordingly, one aim of the proposed work is to conduct translational studies to identify the conditions ..
  38. Effects of Chronic Alcohol Exposure on Synaptic Plasticity in the Prefrontal Cort
    Sven Kroener; Fiscal Year: 2010
    ..in aberrant plasticity, which could contribute to a loss of response inhibition in the PFC that may underlie alcohol drinking behavior. We provide preliminary data that supports this idea...
  39. Rodents with genetic differences in alcohol preference
    RICHARD LOWELL BELL; Fiscal Year: 2013
    ..This high line with both high alcohol drinking preference and high nicotine iv self- administration will then be used to investigate the effects of ..
  40. The role of GLT1 in the modulation of alcohol-drinking behavior in P rats.
    Youssef Sari; Fiscal Year: 2013
    ..The findings generated from this proposal will provide ample information about the role of GLT1 in the regulation of EtOH consumption and will pave the path toward finding a potential therapeutic target for alcohol addiction. ..
  41. Effects of adolescent alcohol exposure on sleep and arousal in adulthood
    Cindy L Ehlers; Fiscal Year: 2013
    ..In the combined model, rats are initiated to limited access alcohol drinking in a runway and are subsequently exposed to intermittent alcohol vapor during the adolescent period...
  42. Molecular Mechanisms of Ethanol Reinforcement
    Clyde W Hodge; Fiscal Year: 2012
    ..We have discovered that voluntary alcohol drinking increases CaMKII1 protein expression in mouse amygdala and that reinstatement of alcohol-seeking behavior is ..
  43. Neurochemical Bases for the Rewarding Effects of Ethanol
    Patricia H Janak; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE The elucidation of the neurotransmitter and receptor systems that support alcohol drinking is critical for understanding how the pharmacological actions of alcohol lead to voluntary intake of alcohol, ..
  44. Myelodysplastic Syndromes: Previous Exposures, Survival, and Quality of Life
    Xiaomei Ma; Fiscal Year: 2010
    ..g. family history, medical history, cigarette smoking, alcohol drinking, exposure to occupational and environmental chemicals, and exercise);3) describe the survival patterns of ..
  45. Molecular Mechanisms of Ethanol Reinforcement
    Clyde W Hodge; Fiscal Year: 2013
    ..We have discovered that voluntary alcohol drinking increases CaMKII1 protein expression in mouse amygdala and that reinstatement of alcohol-seeking behavior is ..
  46. Neuroimmune Interactions in High Alcohol Drinking
    PETER JOHN SYAPIN; Fiscal Year: 2013
    ..Thus, control of high alcohol drinking is an important problem that requires greater understanding at all scientific levels...
  47. Chronic pain and alcohol dependence
    Igor Spigelman; Fiscal Year: 2013
    ..examines the dual consequences of alcohol dependence and chronic (neuropathic) pain development on voluntary alcohol drinking. This aim will be achieved through the combined use of three well-characterized rat models of: a) alcohol ..
  48. Alcohol and inhibition in the prefrontal cortex
    MICHAEL CHARLES SALLING; Fiscal Year: 2013
    ..on GABA and glycine-mediated synaptic and tonic inhibition in the adolescent PFC, and to determine if chronic alcohol drinking during adolescence leads to specific alterations of inhibition that affect neuronal excitability...
  49. TRAINING GRANT ON GENETIC ASPECTS OF ALCOHOLISM
    Cristine L Czachowski; Fiscal Year: 2013
    ..research training on various aspects of the genetics of alcoholism, and mechanisms underlying high alcohol drinking behavior...
  50. CNS SITES FOR THE REWARDING ACTIONS OF ALCOHOL
    William J McBride; Fiscal Year: 2013
    ..the CNS rewarding actions of ethanol, and the contribution of these rewarding effects toward maintaining high alcohol drinking. The overall hypothesis to be tested is that responsiveness of the limbic system to the reinforcing, ..
  51. Ethanol and nicotine co-abuse: cross sensitization of their reinforcing actions
    WILLIAM JOSEPH MCBRIDE; Fiscal Year: 2010
    ..Since alcohol drinking and smoking affect millions of people, this project has potential far reaching impact on improving the health ..
  52. Synaptic mRNA and microRNA: Regulation by chronic alcohol consumption
    Dana Most; Fiscal Year: 2013
    ..The use of mice undergoing an alcohol drinking paradigm will enable us to identify alcohol-responsive synaptic RNAs...
  53. Mouse Target Assessment Core
    Amanda J Roberts; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Heavy alcohol drinking and binge drinking are patterns of alcohol consumption considered abusive and which are associated with increased risk of injuries, physical maladies, mental illness, and ..
  54. Stress and Ethanol Dependence: SK Channels and Glutamate
    Patrick J Mulholland; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Heavy alcohol drinking and repeated withdrawals are associated with increased relapse and allostatic adaptations in the hypothalamic-pituitary-adrenal (HPA) axis...
  55. Molecular regulation of CeA glutamate and binge drinking
    Karen Kathleen Szumlinski; Fiscal Year: 2013
    Abstract/Project Summary Binge alcohol drinking is the most prevalent form of alcoholism within the United States yet the neurobiology of binge drinking is not well-understood...
  56. Doxazosin an a1 Antagonist for Alcohol Dependence
    GEORGE ANTHONY KENNA; Fiscal Year: 2012
    ..target for AD, recent studies have shown that the prototype a1 NE receptor antagonist prazosin reduces alcohol drinking in different animal models...
  57. Socially-facilitated excessive alcohol drinking in a novel prairie vole model
    ALLISON MJ ANACKER; Fiscal Year: 2012
    ..The objective of the proposed studies is to understand the effects of social affiliations on alcohol drinking in a novel animal model for this behavior, the prairie vole, which exhibits strong social bonds and a ..
  58. NAPS2 Continuation - Genome-Wide Association Study of Pancreatitis
    David C Whitcomb; Fiscal Year: 2010
    ..cases of recurrent acute and chronic pancreatitis, plus nearly 700 controls and discovered that excessive alcohol drinking is only found in a minority of patients...
  59. Behavioral Neurobiology of Aggression, Alcohol, GABA, and 5-HT
    Klaus A Miczek; Fiscal Year: 2013
    ..use molecular genetic tools to characterize the CRF and GABA receptor systems during escalated intermittent alcohol drinking and during the ensuing withdrawal aggression...
  60. The Role of Brain Stress Systems in the Prefrontal Cortex in Compulsive Drinking
    Olivier George; Fiscal Year: 2013
    ..of the stress systems in the prefrontal cortex prevents cognitive deficits and the development of compulsive alcohol drinking. The approach combines neuroanatomical, neuropharmacological, and molecular techniques and the use of ..
  61. Colorado Gene Array Core
    Boris Tabakoff; Fiscal Year: 2010
    ..This information will allow for eQTL mapping for rat brain gene expression as well as mapping of QTLs for alcohol drinking in the rat strains...
  62. The role of corticotropin releasing factor in binge-like ethanol drinking
    Todd E Thiele; Fiscal Year: 2013
    ..However, heavy alcohol use and binge alcohol drinking by non-dependent individuals have received far less attention...
  63. Involvement of Aldehydes in Alcohol Addiction
    William McBride; Fiscal Year: 2009
    ..ACD from ethanol (EtOH), and salsolinol (SAL) from ACD and dopamine (DA) contribute to the promotion of high alcohol drinking behavior...
  64. A Forty-Year Followup of Men at High Risk for Alcoholism
    ELIZABETH PENICK; Fiscal Year: 2004
    ..The 30-year followup found that 29 of 73 risk factors predicted alcohol drinking at that point in time...
  65. Alcohol drinking in affiliative rodents
    Andrey Ryabinin; Fiscal Year: 2009
    ..because most laboratory rodents don't display strong affiliative behaviors and don't show high alcohol drinking. However, the situation has changed with increased research on prairie and pine voles, microtine rodents that ..
  66. ALCOHOL EFFECT ON SERUM APOLIPOPROTEINS
    Mark Deeg; Fiscal Year: 2000
    ..cardiovascular disease (ACVD) with moderate alcohol intake but the mortality due to ACVD increases with heavy alcohol drinking and alcohol abuse...
  67. Spirituality and Motives for Drinking and Not Drinking
    Thomas Johnson; Fiscal Year: 2003
    ..The project also provides a means of integrating and testing specific hypotheses regarding the causal links between religiousness/spirituality and alcohol use and problems. ..
  68. BENZODIAZEPINE ACTIONS ON ALCOHOL REINFORCEMENT
    HARRY JUNE; Fiscal Year: 2001
    ..To accomplish this goal, the high alcohol drinking (HAD) rat and measures of ETOH reinforcement will be used...
  69. BENZODIAZEPINE ACTIONS ON ALCOHOL REINFORCEMENT
    HARRY JUNE; Fiscal Year: 2000
    ..To accomplish this goal, the high alcohol drinking (HAD) rat and measures of ETOH reinforcement will be used...