drinking behavior

Summary

Summary: Behaviors associated with the ingesting of water and other liquids; includes rhythmic patterns of drinking (time intervals - onset and duration), frequency and satiety.

Top Publications

  1. ncbi Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population
    Fumihiko Takeuchi
    Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
    Circ J 75:911-8. 2011
  2. ncbi Coffee consumption and risk of liver cancer: a meta-analysis
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Gastroenterology 132:1740-5. 2007
  3. ncbi Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice
    Krisztina M Kovacs
    Laboratory of Neurobehavioral GeneticsNathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Alcohol Clin Exp Res 29:730-8. 2005
  4. ncbi Tea consumption and ovarian cancer risk in a population-based cohort
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, PO Box 210, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Arch Intern Med 165:2683-6. 2005
  5. ncbi Kinematic variables quantifying upper-extremity performance after stroke during reaching and drinking from a glass
    Margit Alt Murphy
    Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Neurorehabil Neural Repair 25:71-80. 2011
  6. ncbi Using the Extrinsic Affective Simon Test as a measure of implicit attitudes towards alcohol: relationship with drinking behavior and alcohol problems
    Peter J de Jong
    University of Groningen, The Netherlands
    Addict Behav 32:881-7. 2007
  7. ncbi Compulsive-like effects of repeated administration of quinpirole on drinking behavior in rats
    Davide Amato
    Department of Human Physiology and Pharmacology Vittorio Erspamer, University of Rome La Sapienza, Piazzale Aldo Moro 5, I 00185 Rome, Italy
    Behav Brain Res 172:1-13. 2006
  8. ncbi The cannabinoid receptor antagonist SR 141716 prevents acquisition of drinking behavior in alcohol-preferring rats
    S Serra
    Neuroscienze S.c.a r.l, Via Palabanda 9, I-09123, Cagliari, Italy
    Eur J Pharmacol 430:369-71. 2001
  9. pmc Controlled water intake: a method for objectively evaluating thirst and hydration state in monkeys by the measurement of blood osmolality
    Hiroshi Yamada
    Center for Neural Science, New York University, New York, NY 10003, USA
    J Neurosci Methods 191:83-9. 2010
  10. pmc Cross-sectional measures and modelled estimates of blood alcohol levels in UK nightlife and their relationships with drinking behaviours and observed signs of inebriation
    Mark A Bellis
    Centre for Public Health, Liverpool John Moores University, 5th Floor Kingsway House, Hatton Garden, Liverpool, L3 2AJ, UK
    Subst Abuse Treat Prev Policy 5:5. 2010

Detail Information

Publications231 found, 100 shown here

  1. ncbi Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population
    Fumihiko Takeuchi
    Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
    Circ J 75:911-8. 2011
    Normative alcohol use (or drinking behavior) influences the risk of cardiovascular disease in a multi-faceted manner...
  2. ncbi Coffee consumption and risk of liver cancer: a meta-analysis
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Gastroenterology 132:1740-5. 2007
    ..We quantitatively assessed the relation between coffee consumption and the risk of liver cancer in a meta-analysis of epidemiologic studies...
  3. ncbi Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice
    Krisztina M Kovacs
    Laboratory of Neurobehavioral GeneticsNathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Alcohol Clin Exp Res 29:730-8. 2005
    ..Here we examined the effects of targeted disruption of kappa-opioid receptor (KOR) on oral alcohol self-administration and other behaviors...
  4. ncbi Tea consumption and ovarian cancer risk in a population-based cohort
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, PO Box 210, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Arch Intern Med 165:2683-6. 2005
    ..Few epidemiologic studies, however, have examined the relationship specifically between tea consumption and risk of ovarian cancer...
  5. ncbi Kinematic variables quantifying upper-extremity performance after stroke during reaching and drinking from a glass
    Margit Alt Murphy
    Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Neurorehabil Neural Repair 25:71-80. 2011
    ..The number of kinematic variables used, however, is diverse, and models for upper-extremity motion analysis vary...
  6. ncbi Using the Extrinsic Affective Simon Test as a measure of implicit attitudes towards alcohol: relationship with drinking behavior and alcohol problems
    Peter J de Jong
    University of Groningen, The Netherlands
    Addict Behav 32:881-7. 2007
    ..Importantly, positive automatic alcohol associations predicted unique variance of alcohol (mis)use and was the single best predictor of individuals' alcohol problems, underlining the idea that they do play a role in alcohol (mis)use...
  7. ncbi Compulsive-like effects of repeated administration of quinpirole on drinking behavior in rats
    Davide Amato
    Department of Human Physiology and Pharmacology Vittorio Erspamer, University of Rome La Sapienza, Piazzale Aldo Moro 5, I 00185 Rome, Italy
    Behav Brain Res 172:1-13. 2006
    ..Fifth, repeated quinpirole produced lasting consequences on drinking behavior, since after rehydration and under drug-free conditions quinpirole-pretreated rats ingested larger amounts ..
  8. ncbi The cannabinoid receptor antagonist SR 141716 prevents acquisition of drinking behavior in alcohol-preferring rats
    S Serra
    Neuroscienze S.c.a r.l, Via Palabanda 9, I-09123, Cagliari, Italy
    Eur J Pharmacol 430:369-71. 2001
    ..3-3 mg/kg, i.p., twice daily for 10 days), prevented the acquisition of alcohol drinking behavior in rats genetically selected for alcohol preference (Sardinian alcohol-preferring (sP) rats), having the ..
  9. pmc Controlled water intake: a method for objectively evaluating thirst and hydration state in monkeys by the measurement of blood osmolality
    Hiroshi Yamada
    Center for Neural Science, New York University, New York, NY 10003, USA
    J Neurosci Methods 191:83-9. 2010
    ..This evidence suggests that osmolality can be used as a tool for monitoring the hydration level of experimental subjects...
  10. pmc Cross-sectional measures and modelled estimates of blood alcohol levels in UK nightlife and their relationships with drinking behaviours and observed signs of inebriation
    Mark A Bellis
    Centre for Public Health, Liverpool John Moores University, 5th Floor Kingsway House, Hatton Garden, Liverpool, L3 2AJ, UK
    Subst Abuse Treat Prev Policy 5:5. 2010
    ..Here we assess mixed survey and modelling techniques as a methodological approach to examining these issues...
  11. ncbi Determinants of adolescents' soft drink consumption
    Elling Bere
    Department of Public Health, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Public Health Nutr 11:49-56. 2008
    ..To identify determinants of adolescents' consumption of carbonated soft drinks (regular and diet), both of total consumption and of consumption at school...
  12. ncbi Central effects of various ligands on drinking behavior in eels acclimated to seawater
    Tomohiro Kozaka
    Laboratory of Integrative Physiology, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    J Exp Biol 206:687-92. 2003
    ..The stimulatory effect of intravenous eANG II disappeared immediately, and was followed by an inhibition, which could be well explained by an increase in eANP secretion from the atrium...
  13. ncbi Coffee, tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey
    Hyon K Choi
    Arthritis Research Centre of Canada, Vancouver General Hospital, University of British Columbia, Vancouver, Canada
    Arthritis Rheum 57:816-21. 2007
    ..Our objective was to evaluate the relationship between coffee, tea, and caffeine intake and serum uric acid level in a nationally representative sample of men and women...
  14. ncbi Effect of water supply method and flow rate on drinking behavior and fluid balance in horses
    S Nyman
    Department of Animal Physiology, Swedish University of Agricultural Sciences, Box 7045, S 750 07 Uppsala, Sweden
    Physiol Behav 73:1-8. 2001
    ..In the second part of the study, drinking behavior and fluid balance were investigated when the horses drank from FV3, PV8, and B for 7 consecutive days in a ..
  15. ncbi Effect of drinker type on water intake and waste in newly weaned piglets
    S Torrey
    Agriculture and Agri Food Canada, Dairy and Swine Research and Development Centre, Sherbrooke, Quebec, J1M 1Z3, Canada
    J Anim Sci 86:1439-45. 2008
    ..This excessive drinking and water wastage can be abated through the use of push-lever drinkers without negative implications for feed intake or growth rates...
  16. ncbi Water intake and wastage at nipple drinkers by growing-finishing pigs
    Y Z Li
    Prairie Swine Centre, Saskatoon SK S7J 5N9, Canada
    J Anim Sci 83:1413-22. 2005
    ..The results indicate that growing-finishing pigs can maintain adequate water intake from a variety of drinker types and management. Water wastage can be controlled through drinker management...
  17. ncbi Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption
    Marilyn C Cornelis
    Department of Nutritional Sciences, University of Toronto, Canada
    Am J Clin Nutr 86:240-4. 2007
    ..Caffeine is the most widely consumed stimulant in the world, and individual differences in response to its stimulating effects may explain some of the variability in caffeine consumption within a population...
  18. ncbi Effects of mouth dryness on drinking behavior and beverage acceptability
    Jeffrey M Brunstrom
    Department of Human Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK
    Physiol Behav 76:423-9. 2002
    ..Typically, drinking behavior produces a concomitant reduction in unpleasant dry mouth sensations...
  19. ncbi The area postrema in hindbrain is a central player for regulation of drinking behavior in Japanese eels
    Shigenori Nobata
    Laboratory of Physiology, Atmosphere and Ocean Research Institute, University of Tokyo, Chiba, Japan
    Am J Physiol Regul Integr Comp Physiol 300:R1569-77. 2011
    ..area postrema (AP), a sensory circumventricular organ (CVO) in the medulla oblongata, in the regulation of drinking behavior of seawater (SW) eels...
  20. ncbi Changes in beverage intake between 1977 and 2001
    Samara Joy Nielsen
    Department of Nutrition, University of North Carolina at Chapel Hill, 27516 3997, USA
    Am J Prev Med 27:205-10. 2004
    ..To examine American beverage consumption trends and causes...
  21. ncbi Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions
    Janne Grønli
    Department of Biomedicine, Section of Physiology, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Physiol Behav 84:571-7. 2005
    ..It is concluded that CMS induces comparable alterations to some depression-like symptoms in humans. Saccharine consumption is not a reliable indicator of the hedonic responsiveness to CMS...
  22. ncbi Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress
    Stéphanie Pothion
    Key Obs SA, Parc Technologique, 3 allée du Titane, 16 rue Leonard de Vinci, 45100 Orleans, France
    Behav Brain Res 155:135-46. 2004
    ..In the Y-maze, UCMS did not modify spontaneous alternation. These results show both an anhedonic-like and an amnesic effect of UCMS in CBA/H mice. They also reveal a difference of sensitivity to UCMS according to the strain of mice...
  23. ncbi Behavioral therapies for overactive bladder: making sense of the evidence
    Jill L Milne
    Adjunct Assistant Professor, Department of Obstetrics and Gynecology, Foothills Medical Centre, Calgary Alberta, Canada
    J Wound Ostomy Continence Nurs 35:93-101; quiz 102-3. 2008
    ..Given the prevalence of OAB and growing support for the efficacy of behavioral treatments it is important and timely to augment existing evidence with well-designed multicenter trials...
  24. ncbi Total and specific fluid consumption as determinants of bladder cancer risk
    Cristina M Villanueva
    Respiratory and Environmental Health Research Unit, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    Int J Cancer 118:2040-7. 2006
    ..The association of bladder cancer with tap water consumption, but not with nontap water fluids, suggests that carcinogenic chemicals in tap water may explain the increased risk...
  25. pmc Tea and coffee drinking and ovarian cancer risk: results from the Netherlands Cohort Study and a meta-analysis
    J Steevens
    Department of Epidemiology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Br J Cancer 97:1291-4. 2007
    ..89, 1.00) and 1.04 (95% CI: 0.97, 1.12) per cup per day, respectively. A meta-analysis also produced no significant findings overall, though the cohort studies showed a significant inverse association for tea...
  26. pmc Phasic and tonic fluctuations in brain, muscle, and skin temperatures during motivated drinking behavior in rats: physiological correlates of motivation and reward
    Michael S Smirnov
    Behavioral Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA
    Brain Res 1310:87-102. 2010
    ..recording from the nucleus accumbens (NAcc), temporal muscle, and facial skin, was used to study motivated drinking behavior in rats...
  27. ncbi Central effects of ghrelin, a unique peptide, on appetite and fluid/water drinking behavior
    Hirofumi Hashimoto
    Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Curr Protein Pept Sci 12:280-7. 2011
    ..Here, we summarise recent findings on the integration of central effects of ghrelin that regulate feeding, release hormones from the pituitary and inhibit fluid/water intake...
  28. ncbi Tool-use for drinking water by immature chimpanzees of Mahale: prevalence of an unessential behavior
    Takahisa Matsusaka
    Laboratory of Human Evolution Studies, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Primates 47:113-22. 2006
    ..We should note here that such behaviors that lack obvious benefits or necessity can be prevalent in a group...
  29. ncbi l-Cysteine reduces oral ethanol self-administration and reinstatement of ethanol-drinking behavior in rats
    Alessandra T Peana
    Laboratory of Cognitive Neuroscience, Department of Drug Sciences, Via Muroni, 23, University of Sassari, 07100 Sassari, Italy
    Pharmacol Biochem Behav 94:431-7. 2010
    ..on the acquisition and maintenance of oral EtOH self-administration and on the reinstatement of EtOH-drinking behavior in Wistar rats...
  30. ncbi The genetics of tea and coffee drinking and preference for source of caffeine in a large community sample of Australian twins
    Michelle Luciano
    Genetic Epidemiology, Queensland Institute of Medical Research, Herston, Brisbane, QLD 4029, Australia
    Addiction 100:1510-7. 2005
    ..To investigate the genetic and environmental influences on tea consumption and their commonalities with coffee consumption; and to further examine the genetic and environmental aetiology of preference for tea/coffee...
  31. ncbi Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Hum Mutat 28:506-10. 2007
    ..polymorphisms adds complexity to differentiating the significance of these two genetic polymorphisms on drinking behavior and alcoholism...
  32. ncbi Nutrient-conditioned flavor preference and incentive value measured by progressive ratio licking in rats
    Anthony Sclafani
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, Brooklyn, NY 11210, United States
    Physiol Behav 88:88-94. 2006
    ....
  33. pmc Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system
    Roberto Ciccocioppo
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    Biol Psychiatry 61:4-12. 2007
    ..Here we evaluated whether buprenorphine, a partial agonist at micro-opioid and NOP receptors, would reduce ethanol consumption in msP rats via activation of NOP receptors...
  34. ncbi Reduction of anxiety after restricted feeding in the rat: implication for eating disorders
    Koki Inoue
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Biol Psychiatry 55:1075-81. 2004
    ..Eating-disorder patients exhibit not only abnormal eating attitudes but also pathologic anxiety-like behaviors. The specific nature of the relationship between dieting and anxiety-like behavior is unknown...
  35. ncbi Chorda tympani nerve transection alters linoleic acid taste discrimination by male and female rats
    Jennifer M Stratford
    Department of Psychology and Program in Neuroscience, The Florida State University, Tallahassee, FL 32306 1270, USA
    Physiol Behav 89:311-9. 2006
    ..Furthermore, sex differences in fat preferences may depend on differences in fatty acid taste thresholds as well as on the taste stimuli with which fat is combined...
  36. ncbi Increased water intake by rats maintained on high NaCl diet: analysis of ingestive behavior
    Edward M Stricker
    Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    Physiol Behav 79:621-31. 2003
    ....
  37. ncbi Alpha2-adrenergic activation in the lateral parabrachial nucleus induces NaCl intake under conditions of systemic hyperosmolarity
    C A F Andrade
    Department of Physiology and Pathology, School of Dentistry, Universidade Estadual Paulista, Rua Humaita 1680, Araraquara, SP 14801 903, Brazil
    Neuroscience 142:21-8. 2006
    ..We suggest that during cell dehydration, circuits subserving sodium appetite are activated, but at the same time strongly inhibited through the lateral parabrachial nucleus...
  38. ncbi Unexpected expression of orexin-B in basal conditions and increased levels in the adult rat hippocampus during pilocarpine-induced epileptogenesis
    Anne Morales
    Laboratoire de Physiologie Intégrative Cellulaire et Moléculaire, UMR 5123 CNRS and Université Claude Bernard Lyon 1, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
    Brain Res 1109:164-75. 2006
    ..The present data suggest that the gene encoding OXs can be activated in the hippocampus, which may play a role in the pathogenesis of epilepsy...
  39. ncbi Endogenous opioids encode relative taste preference
    Sharif A Taha
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, CA 94608, USA
    Eur J Neurosci 24:1220-6. 2006
    ..Our results indicate that endogenous opioid signaling contributes to the encoding of relative reward value...
  40. ncbi Further evidence for the mediation of both subtypes of dopamine D1/D2 receptors and cerebral neuropeptide Y (NPY) in amphetamine-induced appetite suppression
    Dong Yih Kuo
    Department of Physiology, Chung Shan Medical University, Taichung City, Taiwan 402, ROC
    Behav Brain Res 147:149-55. 2003
    ..Taken together, the present results confirmed that both subtypes of D1 and D2 receptors and cerebral NPY were involved in the anorectic action of AMPH...
  41. ncbi Independent effects of diet palatability and fat content on bout size and daily intake in rats
    Zoe S Warwick
    Department of Psychology, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Physiol Behav 80:253-8. 2003
    ....
  42. ncbi Voluntary ethanol consumption decreases after the inactivation of central acetaldehyde by d-penicillamine
    Laura Font
    Area de Psicobiologia, Universitat Jaume I, Castello, Spain
    Behav Brain Res 171:78-86. 2006
    ..These findings indicate that the central inactivation of acetaldehyde blocks ethanol intake in rats, and suggest that acetaldehyde plays a key role in the motivational properties of ethanol...
  43. ncbi Tolerance to amphetamine hypophagia: a real-time depiction of learning to suppress stereotyped movements in the rat
    David L Wolgin
    Department of Psychology, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA
    Behav Neurosci 118:470-8. 2004
    ..On post-tolerance dose-response tests, licking was directly proportional to drug dose in some rats. The results support the view that tolerance to amphetamine hypophagia involves a behavioral adaptation to the motor effects of the drug...
  44. ncbi Abecarnil and palatability: taste reactivity in normal ingestion in male rats
    Steven J Cooper
    Kissileff Laboratory for the Study of Human Ingestive Behaviour, School of Psychology, University of Liverpool, Liverpool L69 7ZA, UK
    Pharmacol Biochem Behav 81:517-23. 2005
    ....
  45. ncbi Calcium deficiency cannot induce obesity in rats
    S Paradis
    Département d anatomie et physiologie, Centre de recherche sur le métabolisme énergétique CREME, Universite Laval, Quebec, Canada, G1K 7P4
    Physiol Behav 85:259-64. 2005
    ..In this experiment, low-calcium intake failed to cause obesity and did not raise the body weight set-point. The results indicate that calcium intake probably does not affect body weight...
  46. ncbi Effects of neuropeptide Y and corticotropin-releasing factor on ethanol intake in Wistar rats: interaction with chronic ethanol exposure
    Annika Thorsell
    The Scripps Research Institute, Department of Neuropharmacology, Mail Drop CVN 14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Behav Brain Res 161:133-40. 2005
    ..Furthermore, the results presented here suggest that a balance between the stress-related peptides NPY and CRF may be involved in the regulation of ethanol intake...
  47. ncbi Temporal and qualitative dynamics of conditioned taste aversion processing: combined generalization testing and licking microstructure analysis
    John Paul Baird
    Department of Psychology, Amherst College, Amherst, MA 01002, US
    Behav Neurosci 119:983-1003. 2005
    ..These results suggest that licking microstructure analysis can be used to assay changes in hedonic evaluation caused by treatments that produce aversive states...
  48. ncbi Calcium deprivation increases the palatability of calcium solutions in rats
    Stuart A McCaughey
    Monell Chemical Senses Center, 3500 Market St, Philadelphia, PA 19104 3308, USA
    Physiol Behav 84:335-42. 2005
    ....
  49. ncbi 5-HT2 and 5-HT3 receptors in the lateral parabrachial nucleus mediate opposite effects on sodium intake
    J I F De Gobbi
    Department of Physiology, Bioscience Institute, Paulista State University UNESP, Distrito de Rubiao Junior, S N, 18618 000 Botucatu, SP, Brazil
    Neuroscience 146:1453-61. 2007
    ..The results provide new information concerning the control of sodium intake by LPBN mechanisms...
  50. ncbi Taste aversion learning induced by delayed swimming activity
    Takahisa Masaki
    Department of Integrated Psychological Science, Kwansei Gakuin University, Nishinomiya 662 8501, Japan
    Behav Processes 67:357-62. 2004
    ..The delayed swimming procedure was as effective as an immediate swimming procedure, extending the generality of the swimming-induced taste aversion, which we recently discovered with the immediate swimming procedure...
  51. ncbi Immunomodulatory activity of triphala on neutrophil functions
    Ramasundaram Srikumar
    Department of Medical Physiology, Immunology Laboratory, Dr A L Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    Biol Pharm Bull 28:1398-403. 2005
    ..Hence our study has divulged that oral administration of Triphala appears to stimulate the neutrophil functions in the immunized rats and stress induced suppression in the neutrophil functions were significantly prevented by Triphala...
  52. ncbi Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist'
    Andrew Gardner
    School of Psychology, University of New England, Armidale NSW, Australia
    Eur J Pharmacol 530:103-6. 2006
    ..However, further studies are needed to confirm the status of O-2050 as a cannabinoid CB(1) receptor antagonist devoid of inverse agonist properties...
  53. ncbi Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats
    Katarzyna Stachowicz
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Eur J Pharmacol 498:153-6. 2004
    ..The results indicate that positive allosteric modulation of mGlu4 receptors may be a useful therapeutic approach to anxiety...
  54. ncbi Lesions of the Edinger-Westphal nucleus in C57BL/6J mice disrupt ethanol-induced hypothermia and ethanol consumption
    Ryan K Bachtell
    Department of Behavioural Neuroscience, Oregon Health and Science University and Portland Alcohol Research Center, Portland, OR 97239, USA
    Eur J Neurosci 20:1613-23. 2004
    ..Taken together, the findings suggest that the EW may function as a sensor for ethanol, which can influence ethanol consumption and preference...
  55. pmc Polycose taste pre-exposure fails to influence behavioral and neural indices of taste novelty
    Sabiha K Barot
    Program of Neurobiology and Behavior, Department of Psychology, University of Washington, Seattle, WA 98195 1525, USA
    Behav Neurosci 119:1640-7. 2005
    ..Novel NaCl, on the other hand, showed patterns of FLI activation and aversion learning similar to that of novel sweet tastes. Possible reasons for the resistance of Polycose to typical pre-exposure effects are discussed...
  56. ncbi Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling
    Aleksandra Klodzinska
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31343 Krakow, Poland
    Neuropharmacology 47:342-50. 2004
    ..These data suggest that selective mGlu5 receptor antagonists mediated anxiolysis is not dependent on GABA-ergic system and that these agents may play a role in the therapy of anxiety...
  57. ncbi Flavour aversion produced by running and attenuated by prior exposure to wheels
    Melissa Baysari
    School of Psychology, University of Sydney, NSW, Australia
    Q J Exp Psychol B 57:273-86. 2004
    ..Instead it seems that increasing exposure to a wheel produces habituation of its nausea-inducing properties...
  58. ncbi Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle
    Hiromi Tsushima
    Department of Cellular and Molecular Pharmacology, Nagoya City University, Japan
    Am J Physiol Regul Integr Comp Physiol 290:R1736-41. 2006
    ..In this study, effects of 4alpha-phorbol 12,13-didecanoate (4alpha-PDD), a TRPV4 agonist, on drinking behavior were examined to investigate roles for TRPV4 as an osmoreceptor in vivo in wild-type animals...
  59. ncbi Intraventricular injections of tachykinin NK3 receptor agonists suppress the intake of "salty" tastes by sodium deficient rats
    Francis W Flynn
    Department of Zoology and Physiology, Graduate Neuroscience Program, University of Wyoming, Laramie, WY 82071, USA
    Behav Brain Res 166:1-8. 2006
    ....
  60. ncbi Involvement of angiotensin II and angiotensin IV in producing the individual characteristics of defensive and feeding behavior in rats
    Yu A Prozherina
    P K Anokhin State Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia
    Neurosci Behav Physiol 38:563-72. 2008
    ..Angiotensin IV had a greater effect than angiotensin II on the defensive behavior of individuals. Individual differences in animal behavior were identified...
  61. ncbi Enhancement of meal-associated hypertonic NaCl intake by moxonidine into the lateral parabrachial nucleus
    Carina A F Andrade
    Department of Physiology and Pathology, School of Dentistry, UNESP, Rua Humaita 1680, Araraquara 14801 903, SP, Brazil
    Behav Brain Res 183:156-60. 2007
    ..Thus, activation of LPBN inhibitory mechanisms seems necessary to restrain sodium intake during a meal...
  62. ncbi Dipsogenic potentiation by sodium chloride but not by sucrose or polyethylene glycol in tuberomammillary-mediated polydipsia
    J Mahía
    Psicobiologia, Universidad de Granada, Campus de Cartuja, Granada, 18071, Spain
    Exp Brain Res 183:27-39. 2007
    ..However, lesions in medial nuclei (E3 or E4) did not produce this increase in food intake. These results are interpreted in relation to the hypothalamic systems involved in food and water intake...
  63. ncbi Temperature and activity responses to sucrose concentration reductions occur on the 1st but not the 2nd day of concentration shifts, and are blocked by low, constant glucocorticoids
    Norman Pecoraro
    Department of Physiology, University of California San Francisco, San Francisco, CA 94113, USA
    Behav Neurosci 121:764-78. 2007
    ....
  64. ncbi Fos-like immunoreactivity and thirst following hyperosmotic loading in rats with subdiaphragmatic vagotomy
    Elizabeth M Starbuck
    Department of Psychology, University of Washington, Box 351525, Seattle 98195 1525, USA
    Brain Res 931:159-67. 2002
    ..Absorption of the larger i.g. load may have activated Fos-ir through more rapidly increasing systemic osmolality, thereby obscuring a role for the vagus at this dose in the SON and magnocellular PVN...
  65. pmc Effects of hindbrain melanin-concentrating hormone and neuropeptide Y administration on licking for water, saccharin, and sucrose solutions
    John Paul Baird
    Department of Psychology and Neuroscience Program, Amherst College, Amherst, MA 01002, USA
    Am J Physiol Regul Integr Comp Physiol 294:R329-43. 2008
    ....
  66. ncbi Neuropeptide Y administration into the third ventricle does not increase sucrose or ethanol self-administration but does affect the cortical EEG and increases food intake
    S N Katner
    The Scripps Research Institute, Department of Neuropharmacology, CVN 14, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 160:146-54. 2002
    ..Several studies have provided indirect evidence that neuropeptide Y (NPY) may play a role in the regulation of ethanol consumption. However, the direct effects of central NPY administration on ethanol drinking are unclear...
  67. pmc Sucrose intake and fasting glucose levels in 5-HT(1A) and 5-HT(1B) receptor mutant mice
    Anita J Bechtholt
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 3403, United States
    Physiol Behav 93:659-65. 2008
    ....
  68. ncbi Ingestive behavior and body temperature during the ovarian cycle in normotensive and hypertensive rats
    Michael E Rashotte
    Department of Psychology, Food, and Exercise Sciences, Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 1270, USA
    Am J Physiol Regul Integr Comp Physiol 282:R216-25. 2002
    ..We propose that estrus-related changes unique to SHR may indicate heightened thermal reactivity to hormonal changes, ingestive behavior, and general locomotor activity...
  69. ncbi Circulating angiotensin II mediates sodium appetite in adrenalectomized rats
    G H Schoorlemmer
    Department of Psychology, University of Iowa, 11 Seashore Hall E, Iowa City, IA 52242-1407, USA
    Am J Physiol Regul Integr Comp Physiol 281:R723-9. 2001
    ..These results indicate that most or all of the sodium appetite of adrenalectomized rats is mediated by circulating ANG II...
  70. ncbi A re-evaluation of the role of tetrahydropapaveroline in ethanol consumption in rats
    John G McCoy
    Department of Psychology, University of Southern Mississippi, Hattiesburg, MS 39406, USA
    Brain Res Bull 60:59-65. 2003
    ..Nonetheless, there are few known compounds that induce a preference for unsweetened alcohol solutions over water in laboratory animals...
  71. pmc Licking for taste solutions by potassium-deprived rats: specificity and mechanisms
    C J Guenthner
    Psychology and Neuroscience, Amherst College, Amherst, MA 01002 United States
    Physiol Behav 93:937-46. 2008
    ..These findings suggest that K(+)-deprivation produces a non-specific appetite that is guided by oral factors. We found no evidence that this response was mediated by ENaC, VR-1, or K(+) channels in taste receptor cells...
  72. pmc Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
    E Tatarczynska
    Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Smetna 12, Poland
    Br J Pharmacol 132:1423-30. 2001
    ..4. These data suggest that selective mGlu5 receptor antagonists may play a role in the therapy of anxiety and/or depression, further studies are required to identify the sites and the mechanism of action of MPEP...
  73. pmc Investigating the motivational mechanism of altered saline consumption following 5-HT(1A) manipulation
    Melissa L Caras
    Program in Neuroscience, Brandeis University, Waltham, MA 02454, USA
    Behav Neurosci 122:407-15. 2008
    ..we use multiple methods to reveal the motivational mechanism whereby 5-HT(1A) receptor activation modulates drinking behavior. Subcutaneous injections of the selective 5-HT(1A) agonist 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT),..
  74. ncbi Synergistic effects of stress and omega-3 fatty acid deprivation on emotional response and brain lipid composition in adult rats
    G Mathieu
    Unité de Nutrition et Régulation Lipidiques des Fonctions Cérébrales, NuReLice, INRA Domaine de Vilvert, 78350 Jouy en Josas, France
    Prostaglandins Leukot Essent Fatty Acids 78:391-401. 2008
    ..The diet-induced AA increase was, however, significantly higher in MS rats. This suggests that n-3 PUFA deficit could be an environmental risk increasing vulnerability to depressive-like response induced by chronic stress...
  75. pmc Hydrogen peroxide-induced inhibition of vasomotor activity: evaluation of single and combined treatments with vitamin A and insulin in streptozotocin-diabetic rats
    Fulya Zobali
    Department of Pharmacology, Faculty of Pharmacy, Ankara University, Tandogan, Turkey
    Int J Exp Diabetes Res 3:119-30. 2002
    ..The use of vitamin A together with insulin provides a better metabolic control and more benefits than use of insulin alone in the reduction of diabetes-induced vascular complications...
  76. ncbi Intake inhibition by NPY: role of appetitive ingestive behavior and aversion
    F Sederholm
    Section of Applied Neuroendocrinology, Karolinska Institutet, Novum S 141 57 Huddinge, Sweden
    Physiol Behav 75:567-75. 2002
    ..It is suggested that NPY decreases intraoral intake and increases appetitive ingestive behavior via partially separable mechanisms that are independent of taste aversion...
  77. ncbi Circadian-dependent and circadian-independent behavioral actions of hypocretin/orexin
    Rodrigo A Espana
    Department of Psychology, University of Wisconsin, 1202 W Johnson St, Madison, WI 53706 1611, USA
    Brain Res 943:224-36. 2002
    ..Additionally, given that chewing and grooming are stress-related behaviors, these observations provide further support for a possible function of HCRT in stress...
  78. ncbi Physical and emotional stress have differential effects on preference for saccharine and open field behaviour in rats
    Femke T A Pijlman
    Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, University Medical Centre Utrecht, P O Box 85060, 3508 AB, Utrecht, The Netherlands
    Behav Brain Res 139:131-8. 2003
    ..In conclusion, stress can induce differential long-term effects on sensitivity to positive stimuli and the response to novelty depending on stress modality...
  79. ncbi Differential spatial representation of taste modalities in the rat gustatory cortex
    Riccardo Accolla
    Flavour Perception Group, Laboratory of Sensory Processing, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Neurosci 27:1396-404. 2007
    ..In summary, we propose that these specific cortical patterns can be used to discriminate among various tastants...
  80. ncbi Intrahippocampal allopregnanolone decreases voluntary chronic alcohol consumption in non-selected rats
    Elena Martin-Garcia
    Institut de Neurociencies, Departament de Psicobiologia i Metodologia de les Ciencies de la Salut, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 31:823-31. 2007
    ..These results indicate that the positive modulation of hippocampal GABA(A) receptors induced by neurosteroids can be an important neurobiological target for reducing chronic alcohol consumption...
  81. ncbi Time of day and access to food alter water intake in rats after water deprivation
    K K Ang
    Department of Medicine, Flinders Medical Centre, The Flinders University of South Australia, Bedford Park, SA Australia
    Clin Exp Pharmacol Physiol 28:764-7. 2001
    ..Our study also supports the validity of performing water intake measurements in thirst studies in rats during the day...
  82. ncbi Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice
    Mufida El-Ghundi
    Department of Pharmacology, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Eur J Neurosci 17:851-62. 2003
    ....
  83. ncbi Rats made cirrhotic by chronic CCl4 treatment still exhibit anticipatory activity to a restricted feeding schedule
    Carolina Escobar
    Departamento de Anatomia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico DF 04510, Mexico
    Chronobiol Int 19:1073-86. 2002
    ..expression of FEO, chronic CCl4-treated cirrhotic rats and oil-treated controls were entrained to RFS and drinking behavior was continuously monitored...
  84. ncbi Anxiolytic-like effect of group III mGlu receptor antagonist is serotonin-dependent
    K Stachowicz
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 52:306-12. 2007
    ....
  85. pmc Intermittent exposure to a social stimulus enhances ethanol drinking in rats
    Arthur Tomie
    Department of Psychology, 152 Freylinghuysen Road, Rutgers University, Piscataway, NJ 08854, USA
    Pharmacol Biochem Behav 87:341-8. 2007
    ..Effects of social stimulation on ethanol drinking are discussed...
  86. ncbi The impact of moderate daily alcohol consumption on aggression and the formation of dominance hierarchies in rats
    Elizabeth A Duncan
    Program in Neuroscience, University of Cincinnati, Cincinnati, OH, USA
    Psychopharmacology (Berl) 189:83-94. 2006
    ..We tested the hypothesis that a history of drinking alcohol would cause SUB rats to consume even greater amounts of alcohol...
  87. ncbi Correlation between fatty acyl composition in neutral and polar lipids and enzyme activities from various tissues of calcium-deficient rats
    Carlos A Marra
    Instituto de Investigaciones Bioquimicas de La Plata, Consejo Nacional de Investigaciones Cientificas y Technicas Universidad Nacional de La Plata, Facultad de Ciencias Medicas, Argentina
    Lipids 37:701-14. 2002
    ..These changes were reflected in the physicochemical properties of the membranes, which in turn inhibits desaturase activities. A possible failure in the transcriptional rate for desaturase-mRNA was also discussed...
  88. ncbi Ventral tegmental lesions reduce overconsumption of normally preferred taste fluid in rats
    Tsuyoshi Shimura
    Laboratory of Behavioral Physiology, Graduate School of Human Sciences, Osaka University, 1 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Behav Brain Res 134:123-30. 2002
    ..0003 M) solution in both the lesioned and sham animals. These results suggest that dopaminergic mediation in the VTA is required to enhance the consumption of normally preferred fluids exclusively...
  89. ncbi Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats
    M Dolores Escarabajal
    Area de Psicobiologia, Universidad de Jaen, 23071, Jaen, Spain
    Psychopharmacology (Berl) 167:130-6. 2003
    ..In spite of many recent studies on the effects of acetaldehyde, it is still unclear whether acetaldehyde mediates the reinforcing and/or aversive effects of ethanol...
  90. ncbi Effects of raclopride in the nucleus accumbens on ethanol seeking and consumption
    C L Czachowski
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Alcohol Clin Exp Res 25:1431-40. 2001
    ..The paradigm used in the present study separated the appetitive or seeking response from the consummatory response to assess the effects of raclopride on both types of ethanol-related behaviors...
  91. ncbi Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior
    Alexander Kuzmin
    Department of Clinical Neuroscience, Division of Drug Dependence, Karolinska University Hospital, Bldg M1 01, 17176, Stockholm, Sweden
    Psychopharmacology (Berl) 203:99-108. 2009
    ....
  92. ncbi Effects of lifelong ethanol consumption on drinking behavior and motor impairment of alcohol-preferring AA and alcohol-avoiding ANA rats
    M Sarviharju
    Department of Mental Health and Alcohol Research, National Public Health Institute, P O Box 719, FIN 00101, Helsinki, Finland
    Alcohol 23:157-66. 2001
    The effects of drinking ethanol throughout a lifetime on voluntary drinking behavior and ethanol-induced motor impairment were studied in alcohol-preferring AA (Alko, Alcohol) and alcohol-avoiding ANA (Alko, Non-Alcohol) rats of both ..
  93. ncbi Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males
    Ru Band Lu
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Alcohol Clin Exp Res 27:889-93. 2003
    ..have the ADH2*2 allele and 50% show ALDH2*1/*2 or ALDH2*2/*2 genotypes, which offer protection against drinking behavior and the risk of developing alcoholism...
  94. ncbi Electroacupuncture stimulation suppresses the increase in alcohol-drinking behavior in restricted rats
    K Yoshimoto
    Department of Legal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi, Kamigyo ku, Kyoto, Japan
    Alcohol Clin Exp Res 25:63S-8S. 2001
    ..The purpose of the present study was to investigate the effect of EAC on changes in alcohol-drinking behavior in rats challenged with restriction and immobilization stress.
  95. pmc Relationship between ethanol's acute locomotor effects and ethanol self-administration in male Long-Evans rats
    Ann M Chappell
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 57157, USA
    Alcohol Clin Exp Res 32:2088-99. 2008
    ..ethanol's stimulant effects may represent important risk factors associated with the development of abusive drinking behavior. Unfortunately, elucidating neurobiologic mechanisms that may underlie these relationships between ethanol ..
  96. ncbi Eating and drinking activity of newly weaned piglets: effects of individual characteristics, social mixing, and addition of extra zinc to the feed
    L Dybkjaer
    Department of Animal Health, Welfare and Nutrition, Danish Institute of Agricultural Sciences, Research Center Foulum, Denmark
    J Anim Sci 84:702-11. 2006
    ..One possibility is that Zn affects eating and drinking behavior. The effects of mixing 4 littermates from each of 2 litters and adding zinc oxide (ZnO; 2,500 ppm of Zn) to ..
  97. ncbi Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat
    P J Larsen
    Department of Medical Anatomy, University of Copenhagen, Denmark
    Endocrinology 138:4445-55. 1997
    ..nervous system, glucagon-like peptide-1-(7-36) amide (GLP-1) acts as a transmitter, inhibiting feeding and drinking behavior. Hypothalamic neuroendocrine neurons are centrally involved in the regulatory mechanisms controlling these ..
  98. pmc Drinking behavior and sources of alcohol: differences between Native American and White youths
    Bettina Friese
    Pacific Institute for Research and Evaluation, Prevention Research Center, 1995 University Avenue, Suite 450, Berkeley, California 94704, USA
    J Stud Alcohol Drugs 72:53-60. 2011
    We investigated drinking behavior and sources of alcohol among Native American and White youths, as well as how underage drinking behavior and sources of alcohol may be related to environmental factors.
  99. ncbi Drinking behavior and sources of alcohol: differences between native american and white youths
    Bettina Friese
    Pacifi c Institute for Research and Evaluation PIRE, Prevention Research Center, 1995 University Avenue, Suite 450, Berkeley, California 94704
    J Stud Alcohol Drugs 72:53-60. 2011
    ABSTRACT. Objective: We investigated drinking behavior and sources of alcohol among Native American and White youths, as well as how underage drinking behavior and sources of alcohol may be related to environmental factors...
  100. pmc Differential effects of dopamine and opioid receptor blockade on motivated Coca-Cola drinking behavior and associated changes in brain, skin and muscle temperatures
    E A Kiyatkin
    Behavioral Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA
    Neuroscience 167:439-55. 2010
    ..in the nucleus accumbens (NAcc), temporal muscle, and facial skin associated with motivated Coca-Cola drinking behavior in rats...
  101. ncbi Differences in the opioid system in selected brain regions of alcohol-preferring and alcohol-nonpreferring rats
    P Fadda
    Department of Neuroscience, University of Cagliari, Italy
    Alcohol Clin Exp Res 23:1296-305. 1999
    ..In addition, evidence obtained in both humans and rats indicates that genetic factors may influence alcohol-drinking behavior. In the present study, we examined several components of the opioid system in selected brain regions of rats ..

Research Grants72

  1. DNA Methylation in Ethanol Drinking Behavior
    David P Gavin; Fiscal Year: 2013
    ..Our principal objective is to determine the role of DNA demethylation in alcohol-drinking behavior utilizing two separate animal models...
  2. NeuroMolecular consequences of adolescent binge drinking
    Toni R Pak; Fiscal Year: 2013
    ..approximately 2, 8, 20, and 50% of teenagers aged 12, 14, 16, and 18 years, respectively, engaged in binge drinking behavior in the month prior to the survey...
  3. Role of Mitochondrial Aldehyde Dehydrogenases in Ethanol Metabolism and Toxicity
    Vasilis Vasiliou; Fiscal Year: 2010
    ..is associated with polymorphisms in the human aldehyde dehydrogenase (ALDH) enzymes;these may influence drinking behavior and risk for developing alcoholic liver disease...
  4. Treatment Implications of Trauma Memory Modulation for PTSD & Alcohol Dependence
    Michael E Saladin; Fiscal Year: 2010
    ..is that effective treatment of PTSD should yield significant reductions in motivation to drink and drinking behavior. There is a developing clinical literature that supports this assumption and the present study will ..
  5. Dorsal Column Stimulation as a New Therapy for Motor Disorders
    Miguel A L Nicolelis; Fiscal Year: 2013
    ..will be used to evaluate the effects of DCS and a DCS/L-dopa combination on general mobility and feeding and drinking behavior. Using the analysis of the electrophysiological recordings obtained from both primate species in cortical ..
  6. The Role of CLOCK in Ethanol-Related Behaviors
    Angela Renee Ozburn; Fiscal Year: 2012
    ..we will determine if CLOCK function in the VTA is important in modulating ethanol intake and relapse-like drinking behavior using RNAi...
  7. Adolescent Binge Drinking Increases Adult Alcohol Intake: Glutamate Mechanisms
    Deborah A Finn; Fiscal Year: 2013
    ..produces alterations in the glutamatergic system that can interact with stress to augment subsequent ethanol drinking behavior, and that adolescent mice may be more susceptible than adult mice to the impact of these perturbations...
  8. HYPOTHALAMIC PEPTIDES IN THE CONTROL OF ALCOHOL INTAKE
    Sarah F Leibowitz; Fiscal Year: 2013
    ..and ENK inputs, have opposite effects on the local peptide systems that determine how they influence ethanol drinking behavior. As pharmacological therapies used to treat alcoholism act in part through these neurochemical control ..
  9. Trial of Nurse-delivered Alcohol Brief Intervention for Hospitalized Veterans
    Lauren Matukaitis Broyles; Fiscal Year: 2013
    ..the alcohol screening status, number of drinks/week, number of binge drinking episodes, readiness to change drinking behavior, and adverse consequences of alcohol use in hospitalized hazardous drinkers...
  10. Ethanol-induced conditioned partner preference in mice
    Ruth I Wood; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Drinking behavior and social context are intimately intertwined, particularly among young adults. Peer relations can promote drinking...
  11. Alcohol Advertising, Drinking and Driving: A Study of Underage Youth and Adults
    Dean R Lillard; Fiscal Year: 2013
    ..may affect whether and how much youth drink, evidence suggests that alcohol advertising may play a role in drinking behavior. In 2006 alcohol manufacturers spent $1...
  12. Molecular mechanisms of excessive alcohol consumption and relapse-like behavior
    REGINALD DEVON CANNADY; Fiscal Year: 2012
    The behavioral and molecular mechanisms underlying excessive alcohol drinking behavior and relapse are not fully understood and are vital for mapping the pathological course of alcoholism/dependence...
  13. New Pharmacotherapy for Alcohol and Co-morbid Disorders
    Bankole A Johnson; Fiscal Year: 2013
    ..those with alcohol dependence not only increases the likelihood of abstinence from smoking but also reduces drinking behavior. Few pharmacotherapy studies have sought medicines that are efficacious at treating both alcohol and ..
  14. White Matter Integrity and Alcohol Use Disorders
    Mollie Monnig; Fiscal Year: 2012
    ..treatment and who had been abstinent for shorter periods of time, thus relating AUD severity and recent drinking behavior to white matter damage (Monnig et al., under review-c)...
  15. Self-Control as a Moderator for Effects of Mass Media on Adolescent Substance Use
    Thomas A Wills; Fiscal Year: 2013
    ..field study through testing how pathways from media exposure to expectancies, peer affiliations, and smoking/drinking behavior differ for self-control subgroups...
  16. Varenicline Treatment for Active Alcholic Smokers
    Richard D Hurt; Fiscal Year: 2012
    ..The investigators will also explore whether varenicline has an effect on drinking behavior among currently drinking alcoholics...
  17. Anxiety and Alcohol Drinking in a Genetic Animal Model of Alcoholism
    JULIA ANN CHESTER; Fiscal Year: 2010
    ..the relationship between susceptibility toward learned fear/anxiety and innate propensity toward alcohol drinking behavior in mouse lines that have been selectively bred for high (HAP1 and HAP2) or low (LAP1 and LAP2) alcohol ..
  18. Effects of ethanol on 5-HT1A receptor density, gene expression and function
    Elizabeth J Burnett; Fiscal Year: 2011
    ..Using a monkey selfadministration paradigm that very closely models human drinking behavior, these approaches will provide novel findings on ethanol's effects on this receptor system, may help to ..
  19. Neuroactive Steroids and Allostasis Induced by Ethanol/Stress
    A Leslie Morrow; Fiscal Year: 2013
    ..results will be integrated with changes in neuronal function, neurochemistry, gene expression and ethanol drinking behavior studies by our collaborators under the same experimental conditions...
  20. Integrated system for phenotyping energy balance and metabolism in animal models
    Daniel Pomp; Fiscal Year: 2010
    ..calorimetry (O2 consumption &CO2 production, respiratory exchange rate, energy expenditure), feeding and drinking behavior (including amounts and time patterns, food preference, and control of food/liquid access), and spontaneous ..
  21. Role of BDNF in Ethanol Dependence and Escalation of Drinking
    Howard C Becker; Fiscal Year: 2013
    ..environmental and experiential factors is known to govern motivation and regulation of alcohol (ethanol) drinking behavior throughout the addiction process...
  22. Ethanol Remodeling of Striatal Microcircuits
    BRIAN NEIL MATHUR; Fiscal Year: 2013
    ..the inhibitory microcircuitry will be reversibly inhibited on-line, with millisecond precision, durng drinking behavior in the DID paradigm using an optogenetics approach in vivo...
  23. Drinking Patterns and Post MI Prognosis in Women
    Murray A Mittleman; Fiscal Year: 2010
    ..We will also evaluate current trends in drinking behavior among women in the US who have coronary heart disease or are at high risk of developing it.
  24. PSYCHOPHYSICAL EVALUATION OF TASTE FUNCTION
    Alan C Spector; Fiscal Year: 2010
    It is uncontested that taste interacts with postingestive physiology to control feeding and drinking behavior, and thus it follows that abnormalities in gustatory processes likely influence more complex clinical disorders nvolving ..
  25. CNS SITES MEDIATING ALCOHOL DRINKING BEHAVIOR
    James M Murphy; Fiscal Year: 2010
    ..by applicant): The objectives of this research are to investigate dopamine (DA) regulation of alcohol drinking behavior within central nervous system (CMS) sites of the mesocorticolimbic DA system that are thought to mediate ..
  26. Citalopram Effects on Craving and Dopamine Receptor Availability in Alcoholics
    Todd Zorick; Fiscal Year: 2013
    ..more severe "Type B" alcohol dependence). Type A alcoholics show decreased drinking behavior in clinical trials with SSRIs, whereas type B alcoholics show increased drinking...
  27. The role of GLT1 in the modulation of alcohol-drinking behavior in P rats.
    Youssef Sari; Fiscal Year: 2013
    ..We will also investigate the effects of GLT1 activation in EtOH-drinking behavior in Wistar rats as comparison control groups...
  28. Effects of Chronic Alcohol Exposure on Synaptic Plasticity in the Prefrontal Cort
    Sven Kroener; Fiscal Year: 2010
    ..plasticity, which could contribute to a loss of response inhibition in the PFC that may underlie alcohol drinking behavior. We provide preliminary data that supports this idea...
  29. Consequences of voluntary intake of ethanol &nicotine during peri-adolescence
    Eric A Engleman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Accumulating evidence points to an intersection between binge drinking behavior, smoking, and the ongoing development of the medial prefrontal cortex, during adolescence...
  30. Social, Familial, Neighborhood Factors and Drinking in Puerto Rico
    Glorisa J Canino; Fiscal Year: 2013
    ..problems, and DSM-IV abuse and dependence;2) To examine the impact of the present economic recession on drinking behavior and associated consequences by examining the association between unemployment and underemployment, stress, ..
  31. Optogenetic studies of hypocretin in binge drinking and negative hedonic valence
    William J Giardino; Fiscal Year: 2013
    ..CRF) and hypocretin systems, and determine how these interactions control the stress response and EtOH drinking behavior. Stress hormone measurements, subtype-specific pharmacology, and transcription factor mapping will provide ..
  32. FAS Prevention: A Trial of the IOM Model
    Philip May; Fiscal Year: 2009
    ..measure change in adult knowledge, attitudes, beliefs, and drinking behavior (KABB) as well as community readiness for change;4...
  33. Epigenetic Profiles Associated with Alcohol Use in At-risk Samples
    Nicole Harlaar; Fiscal Year: 2013
    ..period in which some individuals are at high risk for making the transition from initial alcohol us to risky drinking behavior. It is anticipated that this work will identify a set of reliable and biologically-relevant CpG markers that ..
  34. Circadian Modulation of Alcohol Sensitivity and Tissue Injury in Drosophila
    LISA CARLSON LYONS; Fiscal Year: 2013
    ..Differential sensitivity to alcohol can result in differences in drinking behavior and variation in alcohol toxicity at the cellular and tissue levels...
  35. Mu receptors and ethanol/dopamine interactions
    RUEBEN GONZALES; Fiscal Year: 2009
    The neurochemical and cellular mechanisms that contribute to the control of ethanol drinking behavior are not fully understood, but the involvement of dopamine in the mesolimbic system has been hypothesized for some time...
  36. Genetic architecture of alcohol misuse candidate endophenotypes
    Godfrey D Pearlson; Fiscal Year: 2010
    ..based on several elements, derived from 6-month data on subjects'existing monthly self-reports of drinking behavior on a secure website...
  37. TRAINING GRANT ON GENETIC ASPECTS OF ALCOHOLISM
    Cristine L Czachowski; Fiscal Year: 2013
    ..research training on various aspects of the genetics of alcoholism, and mechanisms underlying high alcohol drinking behavior. The main focus of the research training is on the genetic, biological and molecular basis of high alcohol -..
  38. CNS SITES FOR THE REWARDING ACTIONS OF ALCOHOL
    William J McBride; Fiscal Year: 2013
    ..A better understanding of the complex basic brain mechanisms that contribute to high alcohol drinking behavior is critical for the development of treatment strategies for alcohol abuse.
  39. Neighborhoods, Alcohol Outlets and Intimate Partner Violence
    Carol B Cunradi; Fiscal Year: 2012
    ..By linking individual/couple factors, such as drinking behavior, to environmental factors, this study will help to illuminate the interrelationships between individual and ..
  40. Socially-facilitated excessive alcohol drinking in a novel prairie vole model
    ALLISON MJ ANACKER; Fiscal Year: 2012
    ..2 Determine whether social dominance is linked with influential drinking behavior. As in 1, high and low drinkers will be paired to assess drinking...
  41. Alcohol Involvement in Asian American Men and Women
    Tamara L Wall; Fiscal Year: 2010
    ..in an understudied population, Asian American men and women, during a period of high environmental risk for drinking behavior (college attendance)...
  42. Selectively targeting delta opioid receptor subtypes to control drinking behavior
    Jennifer L Whistler; Fiscal Year: 2013
    ....
  43. Alcohol Epidemiological Data System (AEDS)
    Hsiao ye Yi; Fiscal Year: 2011
    ..studies by applying the lifespan perspective -- the consideration of how the emergence and progression of drinking behavior is influenced by multiple changes (in biology, psychology, and in exposure to social and environmental ..
  44. Alcohol Epidemiological Data System (AEDS)
    Hsiao ye Yi; Fiscal Year: 2012
    ..studies by applying the lifespan perspective -- the consideration of how the emergence and progression of drinking behavior is influenced by multiple changes (in biology, psychology, and in exposure to social and environmental ..
  45. Alcohol Epidemiological Data System (AEDS)
    Hsiao ye Yi; Fiscal Year: 2009
    ..studies by applying the lifespan perspective -- the consideration of how the emergence and progression of drinking behavior is influenced by multiple changes (in biology, psychology, and in exposure to social and environmental ..
  46. Alcohol and Epidemiological Data System (AEDS)
    KAREN STEINMETZ; Fiscal Year: 2011
    ..studies by applying the lifespan perspective -- the consideration of how the emergence and progression of drinking behavior is influenced by multiple changes (in biology, psychology, and in exposure to social and environmental ..
  47. Alcohol Marketing and Underage Drinking
    James D Sargent; Fiscal Year: 2013
    ..planning circuitry is expected in response to viewing the ads, and response levels should predict future drinking behavior. Consistent with our model of marketing effects proposing favorite brand to drink as a key mediating ..
  48. Hangovers and Traffic Injuries: Is Alcohol's Influence Greater Than Expected?
    GORDON STEPHEN SMITH; Fiscal Year: 2013
    ..Aim 1 defines the quantitative relationship between biomarkers for residual effects, self-reported recent drinking behavior and alcohol problems, time of last drink, and symptom scores from the validated "Hangover Scale" among ..
  49. Rat Animal Models and Gene Testing Core
    RICHARD LOWELL BELL; Fiscal Year: 2013
    ..the complex molecular and cellular events that lead to the development and maintenance of excessive alcohol drinking behavior in animal models is highly significant since these findings will provide the necessary foundation for ..
  50. Role of the Endocannabinoid Signaling in Fetal Alcohol Spectrum Disorders
    VINOD K YARAGUDRI; Fiscal Year: 2012
    ..selective abnormalities in the components of endocannabinoid system in the striatum and a greater alcohol drinking behavior in utero alcohol exposed adolescent offspring mice...
  51. Robust Transition Models for the Analysis of Longitudinal Drinking Outcomes
    Stacia DeSantis; Fiscal Year: 2012
    ..drinking do not provide information about the effect of treatment and time dependent comorbidities on daily drinking behavior. To appropriately model the evolution of drinking and non drinking outcomes in response to these variables, ..
  52. Phosphorylation and the CNS Actions of Ethanol
    Dorit Ron; Fiscal Year: 2012
    ..long-lasting facilitation of NR2B-containing NMDAR-mediated activity after ethanol exposure and in ethanol drinking behavior. The NMDAR is an important mediator of ethanol's actions in the brain, and our results suggest that ..
  53. Development & validation of an implicit measure of alcohol-related self-identity
    DEBI A contact LAPLANTE; Fiscal Year: 2010
    ..alcohol abuse among college students require college students to self-report about the antecedents of their drinking behavior. Such assessments present two main limitations: (1) they are relatively insensitive to implicit cognitive ..
  54. Phosphatidylethanol as an Alcohol Biomarker in Patients with Liver Disease
    Scott H Stewart; Fiscal Year: 2011
    ..Thus, it is important to assess drinking behavior in all patients who present with liver disease...
  55. Developing a Dual-Process Intervention for Alcohol Use among Young Adults
    Dana M Litt; Fiscal Year: 2013
    ..relative to an assessment only control, determine if college student status (currently enrolled or not) and drinking behavior (light versus heavy) moderates the efficacy of reasoned versus social interventions, and to determine ..
  56. Behavioral Dysregulation: Impact on Alcohol Cue-Reactivity and Demand for Alcohol
    Joel Erblich; Fiscal Year: 2013
    ..reliably modeled under laboratory conditions, and the magnitude of cue-reactivity has been shown to predict drinking behavior in persons with AUDs...
  57. Monocyte chemotactic protein-1 (MCP-1) modulation of ethanol self-administration
    John Valenta; Fiscal Year: 2013
    ..will investigate the role of a particular neuroimmune signaling molecule, MCP-1, in an animal model of drinking behavior. We will increase or decrease the amount of MCP-1 signaling in the brain and measure the effect on drinking ..
  58. Brief Alcohol Intervention for School-to-Work Transitions
    Suzanne M Colby; Fiscal Year: 2010
    ..specifically designed to test a number of potential mediators that may explain how BMI exerts influence on drinking behavior, including BMI's effects on motivation to change drinking, discrepancy-related processes (e.g...
  59. Ethanol Dependence and Stress Effects on Ethanol Drinking: Role of CRF
    Howard C Becker; Fiscal Year: 2013
    ..an important contributing factor to alcohol abuse and alcoholism, the interaction between stress and ethanol drinking behavior, as well as mechanisms underlying this interaction in the context of dependence are not well understood...
  60. Alcohol Effects on SDF1-Mediated Stem Cell Homing Following Bone Fracture Injury
    John J Callaci; Fiscal Year: 2013
    ..alcohol consumption, and indirectly due to the increased risk for traumatic injury caused by alcohol drinking behavior. Fracture non-union is a condition where a bone fracture injury fails to heal normally requiring surgical ..
  61. Alcohol Research Training: Methods &Mechanisms
    Barbara S McCrady; Fiscal Year: 2013
    ..training to prepare future scientists to conduct research to elucidate the processes of change in drinking behavior, develop and test effective methods to effect change through improved approaches to treatment and indicated ..
  62. Acute effects of alcohol and energy drinks on behavioral control
    Cecile A Marczinski; Fiscal Year: 2010
    ..S. appear to be relatively unchanged from year 2000 levels. The constancy of underage and binge drinking behavior in young people, despite increased attention to this crisis, begs the question of what unexamined factors ..
  63. Involvement of Aldehydes in Alcohol Addiction
    William McBride; Fiscal Year: 2009
    ..ethanol (EtOH), and salsolinol (SAL) from ACD and dopamine (DA) contribute to the promotion of high alcohol drinking behavior. The alcohol-preferring (P) line of rats meets the criteria as an animal model of alcoholism, and is a well ..
  64. ECONOMIC CONDITIONS AND DRINKING BEHAVIOR
    CHRISTOPHER RUHM; Fiscal Year: 2000
    ..It will also supply new information on the costs and benefits of macroeconomic stabilization policies and on the interrelationships between the economic and psychological determinants of health. ..
  65. HBAA--A MARKER OF FETAL ALCOHOL EXPOSURE
    Lewis Holmes; Fiscal Year: 1993
    ..biologic marker that could identify early the high-risk mother, who could be counseled to change her drinking behavior, or that could provide reassurance to the worried pregnant woman concerned about her drinking before she ..
  66. MATERNAL INFLUENCE ON DEVELOPING 24-HOUR PERIODICITY
    STEVEN REPPERT; Fiscal Year: 1991
    ..a biological clock in the fetal suprachiasmatic nuclei (SCN), while pineal N-acetyltransferase activity and drinking behavior are used to monitor the developing circadian system during the postnatal period...
  67. Controlling for Endogeneity Biases in Estimating AA Effects on Drinking Outcomes
    Stephen Magura; Fiscal Year: 2010
    ..drinking;that is, high motivation could well "explain" the observed correlation between AA participation and drinking behavior. The second possible type of artifact is reverse causation, i.e...
  68. RESPONSE TO ALCOHOL IN ASIAN MEN AND WOMEN
    TAMARA WALL; Fiscal Year: 2000
    ..is little information, however, about how these enzyme polymorphisms actually influence an individual's drinking behavior or how sociocultural variables might interact with these biological variables...
  69. LEAD & DEVELOPMENT--IMMUNE & BRAIN STUDIES
    Richard Mailman; Fiscal Year: 1992
    ..One hypothesis, based on our rodent data, is that monkeys will show similar permanent changes in drinking behavior, as well as increases in dipsogenic effects of lithium...
  70. WORK RETIREMENT AND DRINKING AMONG BLUE COLLAR WORKERS
    Samuel Bacharach; Fiscal Year: 2009
    ..of our current 5-year, NIAAA study, which prospectively examines the effect of retirement on the drinking behavior of workers. The purpose of the research is to examine how different levels of social isolation (i.e...
  71. ALCOHOL CONSUMPTION & SPECIFIC CAUSES OF FATAL INJURIES
    Li Hui Chen; Fiscal Year: 2002
    The broad objectives of this proposal are to better understand the relationship between usual drinking behavior and the incidence of various types of fatal injuries among different age, gender, and race/ethnic groups, and to use this to ..
  72. NOVEL NEUROSTEROIDS FOR ALCOHOL-RELATED CONDITIONS
    YUE WEI LEE; Fiscal Year: 2002
    ..have demonstrated that 3alpha,5alpha-THP reduces anxiety and aggression, symptoms that may promote alcohol-drinking behavior. Collectively, these observations suggest a crucial role for 3alpha,5alpha-THP in the regulation of brain ..