- From inflammation to sickness and depression: when the immune system subjugates the brain
Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana Champaign, Illinois 61801, USA
Nat Rev Neurosci 9:46-56. 2008
..immune signalling to the brain can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals...
- Antidepressant drug effects and depression severity: a patient-level meta-analysis
Jay C Fournier
Department of Psychology, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
JAMA 303:47-53. 2010
..medications represent the best established treatment for major depressive disorder, but there is little evidence that they have a specific pharmacological effect relative to pill placebo for patients with less severe depression.
- An inventory for measuring depression
A T Beck
Arch Gen Psychiatry 4:561-71. 1961
- The PHQ-9: validity of a brief depression severity measure
Regenstrief Institute for Health Care and Department of Medicine, Indiana University, Indianapolis 46202, USA
J Gen Intern Med 16:606-13. 2001
While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity.
- Internet-based psychological treatments for depression
Department of Behavioural Sciences and Learning, Linkoping University, SE 58183 Linkoping, Sweden
Expert Rev Neurother 12:861-9; quiz 870. 2012
Major depression is highly prevalent, and is associated with high societal costs and individual suffering. Evidence-based psychological treatments obtain good results, but access to these treatments is limited...
- Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
Jason S Snyder
National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 476:458-61. 2011
..Decreased neurogenesis has been implicated in the pathogenesis of anxiety and depression, but direct evidence for this role is lacking...
- Neurobiology of depression
Eric J Nestler
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Neuron 34:13-25. 2002
Current treatments for depression are inadequate for many individuals, and progress in understanding the neurobiology of depression is slow...
- Collaborative care for depression: a cumulative meta-analysis and review of longer-term outcomes
Department of Health Sciences, University of York, York, England
Arch Intern Med 166:2314-21. 2006
b>Depression is common in primary care but is suboptimally managed...
- The prevalence of comorbid depression in adults with diabetes: a meta-analysis
R J Anderson
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
Diabetes Care 24:1069-78. 2001
OBJECTIVE--To estimate the odds and prevalence of clinically relevant depression in adults with type 1 or type 2 diabetes...
- Depression and type 2 diabetes over the lifespan: a meta-analysis
Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA
Diabetes Care 31:2383-90. 2008
It has been argued that the relationship between depression and diabetes is bi-directional, but this hypothesis has not been explicitly tested...
- Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
M Bryant Howren
Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
Psychosom Med 71:171-86. 2009
To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples.
- Stress, depression, and neuroplasticity: a convergence of mechanisms
Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT 6508, USA
Neuropsychopharmacology 33:88-109. 2008
..Here we provide an overview of the evidence that chronic stress, which can precipitate or exacerbate depression, disrupts neuroplasticity, while antidepressant treatment produces opposing effects and can enhance ..
- Is guided self-help as effective as face-to-face psychotherapy for depression and anxiety disorders? A systematic review and meta-analysis of comparative outcome studies
Department of Clinical Psychology, VU University Amsterdam, The Netherlands
Psychol Med 40:1943-57. 2010
Although guided self-help for depression and anxiety disorders has been examined in many studies, it is not clear whether it is equally effective as face-to-face treatments...
- Motivators and motivations to persist with online psychological interventions: a qualitative study of treatment completers
Brain and Mind Institute, The University of Sydney, Camperdown, Australia
J Med Internet Res 14:e91. 2012
..However, while studies have begun to explore the predictors of dropout in Internet interventions, few have explored reasons why users persist with the programs, which may not just be the converse of the reasons for dropout...
- Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
Denis J David
Université Paris Sud EA 3544, Faculte de Pharmacie, Chatenay Malabry Cedex F 92296, France
Neuron 62:479-93. 2009
..Importantly, mice deficient in one of these genes, beta-arrestin 2, displayed a reduced response to fluoxetine in multiple tasks, suggesting that beta-arrestin signaling is necessary for the antidepressant effects of fluoxetine...
- Cross-national epidemiology of DSM-IV major depressive episode
Department of Psychiatry, State University of New York at Stony Brook, South Campus, Stony Brook, NY 11794 8790, NY, USA
BMC Med 9:90. 2011
Major depression is one of the leading causes of disability worldwide, yet epidemiologic data are not available for many countries, particularly low- to middle-income countries...
- Depression and diabetes: impact of depressive symptoms on adherence, function, and costs
P S Ciechanowski
Box 356560, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
Arch Intern Med 160:3278-85. 2000
b>Depression is common among patients with chronic medical illness...
- The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods
Brenda W J H Penninx
Department of Psychiatry EMGO Institute Institute for Neurosciences, VU University Medical Centre, Amsterdam, The Netherlands
Int J Methods Psychiatr Res 17:121-40. 2008
The Netherlands Study of Depression and Anxiety (NESDA) is a multi-site naturalistic cohort study to: (1) describe the long-term course and consequences of depressive and anxiety disorders, and (2) to integrate biological and psychosocial ..
- Effectiveness of a novel integrative online treatment for depression (Deprexis): randomized controlled trial
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistr 52, Building O59, 20246 Hamburg, Germany
J Med Internet Res 11:e15. 2009
b>Depression is associated with immense suffering and costs, and many patients receive inadequate care, often because of the limited availability of treatment...
- A new approach on stress-related depression & anxiety: Neuro-Psycho- Physical-Optimization with Radio Electric Asymmetric-Conveyer
Rinaldi Fontani Institute, Florence, Italy
Indian J Med Res 132:189-94. 2010
- Association of torture and other potentially traumatic events with mental health outcomes among populations exposed to mass conflict and displacement: a systematic review and meta-analysis
Psychiatry Research and Teaching Unit, School of Psychiatry, University New South Wales, Liverpool New South Wales, Australia
JAMA 302:537-49. 2009
..torture and other potentially traumatic events (PTEs), play in the variation of reported prevalence rates of posttraumatic stress disorder (PTSD) and depression across epidemiologic surveys among postconflict populations worldwide.
- Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness
H S Mayberg
Research Imaging Center, University of Texas Health Science Center at San Antonio, USA
Am J Psychiatry 156:675-82. 1999
..Expanding on this theory, this study examined functional interactions between specific limbic and neocortical regions accompanying normal and disease-associated shifts in negative mood state...
- [Measuring the quality of life in economic evaluations: the Dutch EQ-5D tariff]
L M Lamers
Instituut Beleid en Management Gezondheidszorg, Erasmus MC, Postbus 1738, 3000 DR Rotterdam
Ned Tijdschr Geneeskd 149:1574-8. 2005
..To value EQ-5D health states by a general Dutch public. EQ-5D is a standardised questionnaire that is used to calculate quality-adjusted life-years for cost-utility analysis...
- Effectiveness of a web-based self-help intervention for symptoms of depression, anxiety, and stress: randomized controlled trial
Annemieke van Straten
FPP, Department of Clinical Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
J Med Internet Res 10:e7. 2008
..We developed a new Web-based self-help intervention based on problem-solving therapy, which may be used for people with different types of comorbid problems: depression, anxiety, and work-related stress.
- The Patient Health Questionnaire-2: validity of a two-item depression screener
Regenstrief Institute for Health Care and Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
Med Care 41:1284-92. 2003
A number of self-administered questionnaires are available for assessing depression severity, including the 9-item Patient Health Questionnaire depression module (PHQ-9)...
- Cytokines sing the blues: inflammation and the pathogenesis of depression
Charles L Raison
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
Trends Immunol 27:24-31. 2006
Increasing amounts of data suggest that inflammatory responses have an important role in the pathophysiology of depression. Depressed patients have been found to have higher levels of proinflammatory cytokines, acute phase proteins, ..
- Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): case-control study
Sahlgrenska University Hospital Ostra, Goteborg, Sweden
Lancet 364:953-62. 2004
..The aim of the present analysis was to investigate the relation of psychosocial factors to risk of myocardial infarction in 24767 people from 52 countries...
- Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Nadia M Tsankova
The University of Texas Southwestern Medical Center, Department of Psychiatry and Center for Basic Neuroscience, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
Nat Neurosci 9:519-25. 2006
To better understand the molecular mechanisms of depression and antidepressant action, we administered chronic social defeat stress followed by chronic imipramine (a tricyclic antidepressant) to mice and studied adaptations at the levels ..
- Intimate partner violence against adult women and its association with major depressive disorder, depressive symptoms and postpartum depression: a systematic review and meta-analysis
Hind A Beydoun
Graduate Program in Public Health, Eastern Virginia Medical School, Post Office Box 1980, Norfolk, VA 23501 1980, USA
Soc Sci Med 75:959-75. 2012
..have been conducted to comprehensively evaluate the co-morbidity of intimate partner violence (IPV) and specific depression outcomes in women...
- Normative data for the HADS from a large non-clinical sample
J R Crawford
Department of Psychology, King s College, University of Aberdeen, Aberdeen AB24 2UB, UK
Br J Clin Psychol 40:429-34. 2001
To provide normative data for the Hospital Anxiety Depression Scale (HADS).
- Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy
Division of Cardiology, Department of Medicine, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
Circulation 99:2192-217. 1999
..This evidence is composed largely of data relating CAD risk to 5 specific psychosocial domains: (1) depression, (2) anxiety, (3) personality factors and character traits, (4) social isolation, and (5) chronic life stress...
- Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions
Department of Psychiatry, The University of Texas Southwestern Medical Center UTSWMC, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Cell 131:391-404. 2007
- Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
Elisabeth B Binder
Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
Nat Genet 36:1319-25. 2004
..hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the causality as well as the treatment of depression. To investigate a possible association between genes regulating the HPA axis and response to antidepressants and ..
- The association of depression and anxiety with medical symptom burden in patients with chronic medical illness
Department of Psychiatry, University of Washington School of Medicine, Seattle, WA 98195 6560, USA
Gen Hosp Psychiatry 29:147-55. 2007
Primary care patients with anxiety and depression often describe multiple physical symptoms, but no systematic review has studied the effect of anxiety and depressive comorbidity in patients with chronic medical illnesses.
- IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress
Ja Wook Koo
Department of Psychology, Yale University, New Haven, CT 06520 8205, USA
Proc Natl Acad Sci U S A 105:751-6. 2008
..hippocampus, and blockade of this effect is required for the actions of antidepressants in behavioral models of depression. However, the mechanisms underlying these effects of stress have not been identified...
- Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
Tim F Oberlander
Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
Epigenetics 3:97-106. 2008
- Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS
Department of Psychology, University of Wales Swansea, Swansea, UK
Neuropsychobiology 52:90-110. 2005
The chronic mild stress (CMS) model of depression has high validity but has in the past been criticized for being difficult to replicate...
- Real-time self-regulation of emotion networks in patients with depression
David E J Linden
Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, United Kingdom
PLoS ONE 7:e38115. 2012
Many patients show no or incomplete responses to current pharmacological or psychological therapies for depression. Here we explored the feasibility of a new brain self-regulation technique that integrates psychological and ..
- Exercise for depression
University Hospitals Division, NHS Lothian, Edinburgh, Scotland, UK
Cochrane Database Syst Rev 7:CD004366. 2012
b>Depression is a common and important cause of morbidity and mortality worldwide. Depression is commonly treated with antidepressants and/or psychotherapy, but some people may prefer alternative approaches such as exercise...
- The Liebowitz Social Anxiety Scale: a comparison of the psychometric properties of self-report and clinician-administered formats
D M Fresco
Adult Anxiety Clinic of Temple University, Philadelphia, PA 19122-6085, USA
Psychol Med 31:1025-35. 2001
..CONCLUSION: Results of this study suggest that the self-report version of the LSAS compares well to the clinician-administered version and may be validly employed in the assessment of social anxiety disorder...
- Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease
Mary A Whooley
VA Medical Center, San Francisco, California, USA
JAMA 300:2379-88. 2008
..Depressive symptoms predict adverse cardiovascular outcomes in patients with coronary heart disease, but the mechanisms responsible for this association are unknown...
- Dietary pattern and depressive symptoms in middle age
Tasnime N Akbaraly
Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK
Br J Psychiatry 195:408-13. 2009
Studies of diet and depression have focused primarily on individual nutrients.
- Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies
Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Hauptstrasse 5, 79104 Freiburg, Germany
J Affect Disord 135:10-9. 2011
In many patients with depression, symptoms of insomnia herald the onset of the disorder and may persist into remission or recovery, even after adequate treatment...
- Depression and pain comorbidity: a literature review
Matthew J Bair
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Arch Intern Med 163:2433-45. 2003
Because depression and painful symptoms commonly occur together, we conducted a literature review to determine the prevalence of both conditions and the effects of comorbidity on diagnosis, clinical outcomes, and treatment...
- Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
Wayne C Drevets
Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
Brain Struct Funct 213:93-118. 2008
..Such findings hold major implications for models of the neurocircuits that underlie depression. In particular evidence from lesion analysis studies suggests that the MPFC and related limbic and striato-..
- mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
Science 329:959-64. 2010
..of mTOR signaling completely blocked ketamine induction of synaptogenesis and behavioral responses in models of depression. Our results demonstrate that these effects of ketamine are opposite to the synaptic deficits that result from ..
- The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms
Regenstrief Institute for Health Care, Department of Medicine, Indiana University, RG 6 1050 Wishard Blvd, Indianapolis, IN 46202, USA
Psychosom Med 64:258-66. 2002
..However, instruments for identifying and monitoring somatic symptoms are few in number and not widely used. Therefore, we examined the validity of a brief measure of the severity of somatic symptoms...
- A review of psychological risk factors in back and neck pain
S J Linton
Department of Occupational and Environmental Medicine, Orebro Medical Center, Orebro, Sweden
Spine (Phila Pa 1976) 25:1148-56. 2000
..The literature on psychological factors in neck and back pain was systematically searched and reviewed...
- Depression and obesity: a meta-analysis of community-based studies
Leonore de Wit
Department of Clinical Psychology and EMGO Institute, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
Psychiatry Res 178:230-5. 2010
To examine the nature of the association between depression and obesity and to determine possible underlying (demographic) factors, we conducted a meta-analysis of cross-sectional studies in the general population...
- Depression and diabetes treatment nonadherence: a meta-analysis
Jeffrey S Gonzalez
Behavioral Medicine, Department of Psychiatry, Massachusetts General Hospital Boston, Boston, Massachusetts, USA
Diabetes Care 31:2398-403. 2008
b>Depression is common in patients with diabetes and is associated with worse treatment outcomes. Its relationship to treatment adherence, however, has not been systematically reviewed...
- Internet treatment for depression: a randomized controlled trial comparing clinician vs. technician assistance
Clinical Research Unit for Anxiety and Depression, School of Psychiatry, University of New South Wales at St Vincent s Hospital, Sydney, New South Wales, Australia
PLoS ONE 5:e10939. 2010
Internet-based cognitive behavioural therapy (iCBT) for depression is effective when guided by a clinician, less so if unguided.
- The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex
Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
Behav Brain Res 201:239-43. 2009
A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms...
- Exercise for depression
Gary M Cooney
Division of Psychiatry, Royal Edinburgh Hospital, NHS Lothian, Edinburgh, Midlothian, UK, EH9 1ED
Cochrane Database Syst Rev 9:CD004366. 2013
b>Depression is a common and important cause of morbidity and mortality worldwide. Depression is commonly treated with antidepressants and/or psychological therapy, but some people may prefer alternative approaches such as exercise...
- So depression is an inflammatory disease, but where does the inflammation come from?
IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Vic, Australia
BMC Med 11:200. 2013
We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system...
- Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt
Nature 266:730-2. 1977
- NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Anita E Autry
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9111, USA
Nature 475:91-5. 2011
..Our findings indicate that the regulation of protein synthesis by spontaneous neurotransmission may serve as a viable therapeutic target for the development of fast-acting antidepressants...
- Glucocorticoids, cytokines and brain abnormalities in depression
Patricia A Zunszain
Stress, Psychiatry and Immunology Laboratory SPI Lab, Department of Psychological Medicine, Institute of Psychiatry, King s College London, 125 Coldharbour Lane, SE59NU London, United Kingdom
Prog Neuropsychopharmacol Biol Psychiatry 35:722-9. 2011
Major depression (MD) is a common psychiatric disorder with a complex and multifactor aetiology...
- Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
J Neurosci 22:3251-61. 2002
..to test the hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms...
- Socioeconomic inequalities in depression: a meta-analysis
Health Systems Research, School of Public Health, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
Am J Epidemiol 157:98-112. 2003
..Among psychiatric disorders, depression exhibits a more controversial association with SES...
- Exercise builds brain health: key roles of growth factor cascades and inflammation
Carl W Cotman
University of California, Irvine Institute for Brain Aging and Dementia, 1113 Gillespie Building, Irvine, CA 92617 4540, USA
Trends Neurosci 30:464-72. 2007
..of exercise have been best defined for learning and memory, protection from neurodegeneration and alleviation of depression, particularly in elderly populations...
- Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis
School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Diabetologia 53:2480-6. 2010
An earlier meta-analysis showed that diabetes is a risk factor for the development and/or recurrence of depression. Yet whether this risk is different for studies using questionnaires than for those relying on diagnostic criteria for ..
- Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence
David M Clarke
Psychological Medicine, Monash University, Melbourne, Vic, Australia
Med J Aust 190:S54-60. 2009
To review the evidence for an association between depression and anxiety and the National Health Priority Area conditions -- heart disease, stroke, diabetes mellitus, asthma, cancer, arthritis and osteoporosis -- and for the effectiveness ..
- Reconsidering anhedonia in depression: lessons from translational neuroscience
Michael T Treadway
Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
Neurosci Biobehav Rev 35:537-55. 2011
..These proposed modifications to the theoretical definition of anhedonia have implications for research, assessment and treatment of MDD...
- Epidemiology of women and depression
Ronald C Kessler
Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Suite 215, Boston, MA 02115 5899, USA
J Affect Disord 74:5-13. 2003
b>Depression is the leading cause of disease-related disability among women in the world today. Depression is much more common among women than men, with female/male risk ratios roughly 2:1.
- Bidirectional association between depression and type 2 diabetes mellitus in women
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Arch Intern Med 170:1884-91. 2010
Although it has been hypothesized that the diabetes-depression relation is bidirectional, few studies have addressed this hypothesis in a prospective setting.
- Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment
Helen S Mayberg
Department of Psychiatry and the Rotman Research Institute, University of Toronto, Ontario, Canada
Br Med Bull 65:193-207. 2003
While characterization of pathogenetic mechanisms underlying major depression is a fundamental aim of neuroscience research, an equally critical clinical goal is to identify biomarkers that might improve diagnostic accuracy and guide ..
- Cognitive theory and therapy of anxiety and depression: convergence with neurobiological findings
David A Clark
Department of Psychology, University of New Brunswick, P O Box 4400, Fredericton, New Brunswick E3B5A3, Canada
Trends Cogn Sci 14:418-24. 2010
..Beck's cognitive formulation of anxiety and depression is proposed that provides an elaborated account of the cognitive and neural mediational processes of cognitive ..
- The ascent of mouse: advances in modelling human depression and anxiety
John F Cryan
Neuroscience Research, Novartis Institutes for BioMedical Research, Basel CH 4055, Switzerland
Nat Rev Drug Discov 4:775-90. 2005
..The success of this approach is largely contingent on the usefulness of available behavioural models of depression- and anxiety-related behaviours in mice...
- A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults
Jun S Lai
Priority Research Centre for Gender, Health and Ageing JSL and AJH, the Priority Research Centre for Translational Neuroscience and Mental Health SH, and the Centre for Clinical Epidemiology and Biostatistics MM and JA, University of Newcastle, New South Wales, Australia The Hunter Medical Research Institute, Newcastle, New South Wales, Australia AB, AJH, and JA and the John Hunter Hospital, Newcastle, New South Wales, Australia JA
Am J Clin Nutr 99:181-97. 2014
Studies of single nutrients on depression have produced inconsistent results, and they have failed to consider the complex interactions between nutrients...
- Physical activity, exercise, depression and anxiety disorders
Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
J Neural Transm (Vienna) 116:777-84. 2009
..with respect to (1) the association of physical activity, exercise and the prevalence and incidence of depression and anxiety disorders and (2) the potential therapeutic activity of exercise training in patients with ..
- New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors
Maes 998 Rimklongsamsen Road, Bangkok 10310, Thailand
Inflammopharmacology 20:127-50. 2012
This paper reviews new drug targets in the treatment of depression and new drug candidates to treat depression...
- Depressed mood in pregnancy: prevalence and correlates in two Cape Town peri-urban settlements
Department of Psychology, Stellenbosch University, Private Bag X1, Matieland, 7602, South Africa
Reprod Health 8:9. 2011
The disability associated with depression and its impact on maternal and child health has important implications for public health policy...
- The NPY system in stress, anxiety and depression
Division of Psychiatry, Neurotec Department, Karolinska Institute, Huddinge University Hospital M57, Stockholm 141 86, Sweden Laboratory of Clinical Science, NIAAA NIH, Bethesda, MD, USA
Neuropeptides 38:213-24. 2004
..NPY system as a target for novel pharmacological treatments of stress-related disorders, including anxiety and depression. Development of Y2 antagonists presently appears to offer the most promising strategy for developing these ..
- Burden, depression, and anxiety in caregivers of people with amyotrophic lateral sclerosis
Department of Psychology, Catholic University of Milan, Milan, Italy
Psychol Health Med 15:685-93. 2010
..We conducted a cross-sectional study among 40 ALS caregivers, assessing general worries, burden of care, depression, anxiety, perception of social support, and patients' severity of disease...
- Depression in the elderly
George S Alexopoulos
Weill Medical College of Cornell University and Weill Cornell Institute of Geriatric Psychiatry, 21 Bloomingdale Road, White Plains, New York, NY 10605, USA
Lancet 365:1961-70. 2005
In elderly people, depression mainly affects those with chronic medical illnesses and cognitive impairment, causes suffering, family disruption, and disability, worsens the outcomes of many medical illnesses, and increases mortality...
- Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research Study
J R Ickovics
Yale University, Department of Epidemiology and Public Health, PO Box 208034, 60 College St, Suite 415, New Haven, CT 06520 8034, USA
JAMA 285:1466-74. 2001
The impact of depression on morbidity and mortality among women with human immunodeficiency virus (HIV) has not been examined despite the fact that women with HIV have substantially higher rates of depression than their male counterparts.
- Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial
Lisa F Berkman
Harvard University, Boston, MA, USA
JAMA 289:3106-16. 2003
b>Depression and low perceived social support (LPSS) after myocardial infarction (MI) are associated with higher morbidity and mortality, but little is known about whether this excess risk can be reduced through treatment.
- Depression and cardiac disease: a review
Christopher M Celano
Harvard Medical School, Boston, MA, USA
Cardiol Rev 19:130-42. 2011
b>Depression is highly prevalent in cardiac patients, with 20% to 40% of patients meeting criteria for major depressive disorder or experiencing an elevation in depressive symptoms...
- Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Science 311:864-8. 2006
..These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences...
- Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence
M R DiMatteo
Department of Psychology, University of California, Riverside, CA 92521, USA
Arch Intern Med 160:2101-7. 2000
b>Depression and anxiety are common in medical patients and are associated with diminished health status and increased health care utilization...
- Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
Science 301:386-9. 2003
In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others...
- Family caregiving of persons with dementia: prevalence, health effects, and support strategies
University Center for Social and Urban Research, University of Pittsburgh, Pittsburgh, PA 15260, USA
Am J Geriatr Psychiatry 12:240-9. 2004
..health effects of caregiving, and reviews various intervention approaches to improving caregiver burden, depression, and quality of life...
- The Hospital Anxiety And Depression Scale
R Philip Snaith
Senior Lecturer in Psychiatry, University of Leeds, 21 Gledhow Wood Road, Leeds LS8 4BW, UK
Health Qual Life Outcomes 1:29. 2003
There is a need to assess the contribution of mood disorder, especially anxiety and depression, in order to understand the experience of suffering in the setting of medical practice...
- Systemic inflammation, depression and obstructive pulmonary function: a population-based study
Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, and Department of Psychological Medicine, National University Hospital System, NUHS Tower Block, 9th Floor, 1E Kent Ridge Road, 119228 Singapore, Singapore
Respir Res 14:53. 2013
..are known to be elevated in chronic diseases including chronic obstructive pulmonary disease (COPD) and depression. Comorbid depression is common in patients with COPD, but no studies have investigated whether proinflammatory ..
- The molecular neurobiology of depression
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Nature 455:894-902. 2008
Unravelling the pathophysiology of depression is a unique challenge. Not only are depressive syndromes heterogeneous and their aetiologies diverse, but symptoms such as guilt and suicidality are impossible to reproduce in animal models...
- Yoga for depression: a systematic review and meta-analysis
Department of Internal and Integrative Medicine, Kliniken Essen Mitte, Faculty of Medicine, University of Duisburg Essen, Essen, Germany
Depress Anxiety 30:1068-83. 2013
Mind-body medical interventions are commonly used to cope with depression and yoga is one of the most commonly used mind-body interventions...
- Patterns of association between alcohol consumption and symptoms of depression and anxiety in young adults
T M Caldwell
Centre for Mental Health Research, Australian National University, Canberra, ACT
Addiction 97:583-94. 2002
..Little is known about the age at which this develops. This paper examines levels of affect, depression and anxiety over the full range of alcohol consumption in young adults.
- Collaborative care for depression and anxiety problems
School of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK
Cochrane Database Syst Rev 10:CD006525. 2012
Common mental health problems, such as depression and anxiety, are estimated to affect up to 15% of the UK population at any one time, and health care systems worldwide need to implement interventions to reduce the impact and burden of ..
- Association of perceived medical errors with resident distress and empathy: a prospective longitudinal study
Colin P West
Division of General Internal Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
JAMA 296:1071-8. 2006
..Medical errors are associated with feelings of distress in physicians, but little is known about the magnitude and direction of these associations...
- Depression and risk of stroke morbidity and mortality: a meta-analysis and systematic review
Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
JAMA 306:1241-9. 2011
Several studies have suggested that depression is associated with an increased risk of stroke; however, the results are inconsistent.
- Burnout and self-reported patient care in an internal medicine residency program
Tait D Shanafelt
University of Washington, Veterans Affairs Northwest Health Services Research and Development Center of Excellence, and Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
Ann Intern Med 136:358-67. 2002
..Burnout is a syndrome of depersonalization, emotional exhaustion, and a sense of low personal accomplishment. Little is known about burnout in residents or its relationship to patient care...
- Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Prog Neuropsychopharmacol Biol Psychiatry 39:112-9. 2012
..We investigated the effects of chronic restraint stress (CRS: 6 hours × 28 days) on anxiety- and depression-like behaviors in rats and on the possible changes in glucocorticoid receptor (GR) expression as well as brain-..
- Review of internet-based prevention and treatment programs for anxiety and depression in children and adolescents
Alison L Calear
Centre for Mental Health Research, Australian National University, Canberra, ACT, Australia
Med J Aust 192:S12-4. 2010
To identify and describe current internet-based prevention and treatment programs for anxiety and depression in children and adolescents.
- Adherence in internet interventions for anxiety and depression
Centre for Mental Health Research, Australian National University, Canberra ACT 0200, Australia
J Med Internet Res 11:e13. 2009
Open access websites which deliver cognitive and behavioral interventions for anxiety and depression are characterised by poor adherence...
- Social ties and mental health
The Department of Health and Social Behavior, Harvard Center for Society and Health, 677 Huntington Avenue, Boston, MA 02115, USA
J Urban Health 78:458-67. 2001
- Psychosocial factors at work and risk of depression: a systematic review of the epidemiological evidence
J P E Bonde
Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, Building 2C, DK 8000 Aarhus C, Denmark
Occup Environ Med 65:438-45. 2008
Major depression is a leading cause of psychiatric morbidity and may be influenced by psychosocial factors in the workplace, although evidence so far remains circumstantial...
- The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling
J M Bessa
Life and Health Science Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
Mol Psychiatry 14:764-73, 739. 2009
The mechanisms underlying the initiation/onset of, and the recovery from, depression are still largely unknown; views that neurogenesis in the hippocampus may be important for the pathogenesis and amelioration of depressive symptoms have ..
- Enhanced depression care for patients with acute coronary syndrome and persistent depressive symptoms: coronary psychosocial evaluation studies randomized controlled trial
Karina W Davidson
Department of Medicine, Columbia University College of Physicians and Surgeons, PH9 Center, 622 W 168th St, Room 948, New York, NY 10032, USA
Arch Intern Med 170:600-8. 2010
..This study was conducted to determine the acceptability and efficacy of enhanced depression treatment in patients with ACS.
- A yoga intervention for young adults with elevated symptoms of depression
University of California, Los Angeles, USA
Altern Ther Health Med 10:60-3. 2004
Yoga teachers and students often report that yoga has an uplifting effect on their moods, but scientific research on yoga and depression is limited.
- The relation between work-related psychosocial factors and the development of depression
Clinic of Occupational Medicine, Hillerød Hospital, Helsevej 2, DK 3400 Hillerød, Denmark
Epidemiol Rev 30:118-32. 2008
..criteria: 1) a longitudinal study, 2) exposure to work-related psychosocial factors, 3) the outcome a measure of depression, 4) relevant statistical estimates, and 5) nonduplicated publication...