Genomes and Genes
Summary: A false belief regarding the self or persons or objects outside the self that persists despite the facts, and is not considered tenable by one's associates.
Publications340 found, 100 shown here
- Toward a neurobiology of delusionsP R Corlett
Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Centre, Abraham Ribicoff Research Facility, 34 Park Street, New Haven, CT 06519, USA
Prog Neurobiol 92:345-69. 2010b>Delusions are the false and often incorrigible beliefs that can cause severe suffering in mental illness. We cannot yet explain them in terms of underlying neurobiological abnormalities...
- Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophreniaShitij Kapur
Clarke Division of the Centre for Addiction and Mental Health, 250 College St, Toronto, Ont M5T 1R8, Canada
Am J Psychiatry 160:13-23. 2003..The objective of this overview is to link the neurobiology (brain), the phenomenological experience (mind), and pharmacological aspects of psychosis-in-schizophrenia into a unitary framework...
- The past and future of delusions research: from the inexplicable to the treatableP A Garety
P A Garety, MA, MPhil, MA Ed, PhD, FBPsS, Department of Psychology, Institute of Psychiatry, King s College London D Freeman, PhD, DClinPsy, CPsychol, FBPsS, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
Br J Psychiatry 203:327-33. 2013Problems with the diagnosis and treatment of schizophrenia have led for a call to change strategy and focus on individual psychotic experiences. In recent years, research on delusions has led the way.
- The cognitive and affective structure of paranoid delusions: a transdiagnostic investigation of patients with schizophrenia spectrum disorders and depressionRichard P Bentall
School of Psychology, Adeilad Brigantia Bldg, Penrallt Road, Gwynedd, Wales
Arch Gen Psychiatry 66:236-47. 2009Paranoid delusions are a common symptom of a range of psychotic disorders...
- A cognitive model of persecutory delusionsDaniel Freeman
Department of Psychology, Institute of Psychiatry, King s College London, UK
Br J Clin Psychol 41:331-47. 2002A multifactorial model of the formation and maintenance of persecutory delusions is presented. Persecutory delusions are conceptualized as threat beliefs...
- Evidence for sensory prediction deficits in schizophreniaSukhwinder S Shergill
Institute of Neurology, University College London
Am J Psychiatry 162:2384-6. 2005Patients with schizophrenia experiencing delusions and hallucinations can misattribute their own actions to an external source...
- Emotions, self-esteem, and paranoid episodes: an experience sampling studyViviane Thewissen
Open University of the Netherlands, Heerlen
Br J Clin Psychol 50:178-95. 2011..Clinicians need to be aware of the central role of emotion-related processes and especially self-esteem in paranoid thinking...
- Connecting neurosis and psychosis: the direct influence of emotion on delusions and hallucinationsDaniel Freeman
Department of Psychology, Institute of Psychiatry, King s College London, University of London, Denmark Hill, London SE5 8AF, UK
Behav Res Ther 41:923-47. 2003..Psychological theories and experimental evidence concerning the influence of emotion on the content and form of delusions and hallucinations are therefore reviewed...
- Suspicious minds: the psychology of persecutory delusionsDaniel Freeman
Department of Psychology, Institute of Psychiatry, King s College London, Denmark Hill, London, UK
Clin Psychol Rev 27:425-57. 2007At least 10-15% of the general population regularly experience paranoid thoughts and persecutory delusions are a frequent symptom of psychosis. Persecutory ideation is a key topic for study...
- Reasoning, emotions, and delusional conviction in psychosisPhilippa A Garety
Department of Psychology, Institute of Psychiatry, King s College London, London, England
J Abnorm Psychol 114:373-84. 2005..One hundred participants with current delusions, recruited for a treatment trial of psychological therapy (PRP trial), were assessed at baseline on measures of ..
- Targeting reasoning biases in delusions: a pilot study of the Maudsley Review Training Programme for individuals with persistent, high conviction delusionsHelen Waller
Institute of Psychiatry, King s College London, P O Box P077, 16 De Crespigny Park, London SE5 8AF, UK
J Behav Ther Exp Psychiatry 42:414-21. 2011b>Delusions are often resistant to change, persisting despite successful antipsychotic treatment or Cognitive Behavioural Therapy...
- Impact of state anxiety on the jumping to conclusions delusion biasSuzanne Ho Wai So
Department of Psychology, Institute of Psychiatry, King s College, London, London, UK
Aust N Z J Psychiatry 42:879-86. 2008..This is the first study to investigate the relationship between the level of state anxiety and the jumping to conclusions (JTC) reasoning bias in patients with first-episode psychosis using an experimental manipulation procedure...
- The psychological effect of an urban environment on individuals with persecutory delusions: the Camberwell walk studyLyn Ellett
Department of Psychology, Institute of Psychiatry, King s College London, University of London, UK
Schizophr Res 99:77-84. 2008..and clinical effects of exposure to one specific deprived urban environment on individuals with persecutory delusions. It was predicted that the urban environment would affect emotional and reasoning processes highlighted in a ..
- Developing treatments of persistent persecutory delusions: the impact of an emotional processing and metacognitive awareness interventionClaire Hepworth
Department of Psychology, Institute of Psychiatry, King s College London, London
J Nerv Ment Dis 199:653-8. 2011Worry has been implicated in increasing the levels of distress associated with persecutory delusions. It may partly cause this distress via the impediment of emotional processing of upsetting experiences...
- Evidence that onset of psychosis in the population reflects early hallucinatory experiences that through environmental risks and affective dysregulation become complicated by delusionsFeikje Smeets
Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
Schizophr Bull 38:531-42. 2012To examine the hypothesis that the "natural" combination of delusions and hallucinations in psychotic disorders in fact represents a selection of early subclinical hallucinatory experiences associated with delusional ideation, resulting ..
- Cognitive behavioural treatment of insomnia in individuals with persistent persecutory delusions: a pilot trialElissa Myers
King s College London, Institute of Psychiatry, UK
J Behav Ther Exp Psychiatry 42:330-6. 2011..The clinical implication is that reducing insomnia will reduce paranoid delusions. This study, evaluating for the first time the treatment of insomnia in individuals with persecutory delusions, ..
- Measuring ideas of persecution and social reference: the Green et al. Paranoid Thought Scales (GPTS)C E L Green
Department of Psychology, Institute of Psychiatry, King s College London, UK
Psychol Med 38:101-11. 2008....
- Psychotic-like experiences in major depression and anxiety disorders: a population-based survey in young adultsDaniel Varghese
Department of Psychiatry, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
Schizophr Bull 37:389-93. 2011..However, it is unclear if these experiences are associated with common mental disorders. The aim of this study was to examine the prevalence of psychotic-like experiences in those with affective and anxiety disorders...
- A randomized experimental investigation of reasoning training for people with delusionsKerry Ross
Department of Psychology, Institute of Psychiatry, King s College London, DeCrespigny Park, London, UK
Schizophr Bull 37:324-33. 2011..a brief reasoning training module changes the "jumping to conclusions" data gathering bias in people with delusions. A secondary aim was to examine whether improvements in reasoning would lead to greater flexibility in thinking ..
- Testing the continuum of delusional beliefs: an experimental study using virtual realityDaniel Freeman
Department of Psychology, Institute of Psychiatry, King s College London, London, England
J Abnorm Psychol 119:83-92. 2010..The second objective was to investigate, drawing upon a cognitive model of persecutory delusions, whether clinical and nonclinical paranoia are associated with similar causal factors...
- Comments on the content of persecutory delusions: does the definition need clarification?D Freeman
Department of Psychology, King s College London, University of London, UK
Br J Clin Psychol 39:407-14. 2000..In this article, several influential accounts of persecutory delusions are reviewed; differences and difficulties are noted, and their potential effect on cognitive psychological ..
- Improving cognitive treatments for delusionsDaniel Freeman
Department of Psychiatry, Oxford University, Warneford Hospital, Oxford, OX3 7JX, UK
Schizophr Res 132:135-9. 2011..These therapies now lag behind the transformation over the past ten years in understanding the causes of delusions. This paper advocates an interventionist-causal model approach: to focus on one putative causal factor at a time,..
- Dimensional approach to delusions: comparison across types and diagnosesP S Appelbaum
Department of Psychiatry, University of Massachusetts Medical School, Worcester 01655, USA
Am J Psychiatry 156:1938-43. 1999A dimensional approach to the characterization of delusions was used to examine the use of non-content-related descriptors of delusions in revealing differences across diagnostic categories and delusion types.
- Hopping, skipping or jumping to conclusions? Clarifying the role of the JTC bias in delusionsCordelia Fine
Centre for Applied Philosophy and Public Ethics, Department of Philosophy, University of Melbourne, Victoria, Australia
Cogn Neuropsychiatry 12:46-77. 2007There is substantial evidence that patients with delusions exhibit a reasoning bias--known as the "jumping to conclusions" (JTC) bias--which leads them to accept hypotheses as correct on the basis of less evidence than controls...
- Neuropsychological functioning and jumping to conclusions in delusionsPhilippa Garety
Department of Psychology, Institute of Psychiatry, King s College London, London, UK Electronic address
Schizophr Res 150:570-4. 2013It has been consistently demonstrated that delusions are related to jumping to conclusions (JTC), a data-gathering bias and potential candidate endophenotype of psychosis...
- The neurobiology of schizotypy: fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy peopleP R Corlett
Connecticut Mental Health Center, Yale University, Department of Psychiatry, Ribicoff Research Facility 34 Park Street, New Haven, CT 06519, USA
Neuropsychologia 50:3612-20. 2012....
- Self-attacking and self-reassurance in persecutory delusions: a comparison of healthy, depressed and paranoid individualsPaul Hutton
Psychosis Research Unit, Psychology Department, Trust HQ, Greater Manchester West Mental Health Foundation NHS Trust, Bury New Road, Prestwich M25 3BL, United Kingdom
Psychiatry Res 205:127-36. 2013..To investigate this further, we asked 15 people with persecutory delusions, 15 people with depression and 19 non-psychiatric controls to complete several self-report questionnaires ..
- Explaining transitions over the hypothesized psychosis continuumLydia Krabbendam
Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, Maastricht, University, The Netherlands
Aust N Z J Psychiatry 39:180-6. 2005....
- Metacognitive training in schizophrenia: from basic research to knowledge translation and interventionSteffen Moritz
University Medical Center Hamburg Eppendorf, Department for Psychiatry and Psychotherapy, Hamburg, Germany
Curr Opin Psychiatry 20:619-25. 2007..We summarize new evidence on cognitive biases thought to trigger or maintain positive symptoms in schizophrenia and present a new therapeutic intervention...
- Emotion and psychosis: links between depression, self-esteem, negative schematic beliefs and delusions and hallucinationsBen Smith
UCL, Department of Mental Health Sciences, Archway Campus, Holborn Union Building, Highgate Hill, London, UK
Schizophr Res 86:181-8. 2006..A., Kuipers, E.K., Fowler, D., Freeman, D., Bebbington, P.E., 2001. A cognitive model of the positive symptoms of psychosis. Psychological Medicine, 31, 189-195] about the role of emotion and negative evaluative beliefs in psychosis...
- The psychology of persecutory ideation I: a questionnaire surveyDaniel Freeman
Department of Psychology, Institute of Psychiatry, King s College London, London, United Kingdom
J Nerv Ment Dis 193:302-8. 2005..In a recent cognitive model of persecutory delusions, three key factors are highlighted: anomalous experiences, emotion, and reasoning...
- The association between delusional-like experiences and suicidal thoughts and behaviourSukanta Saha
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
Schizophr Res 132:197-202. 2011..Whilst it is well known that psychotic disorders increase the risk of suicide, it is unclear if DLEs are also associated with suicidal thoughts and behaviour. This study aims to explore these variables in a large population-based sample...
- Jumping to delusions? Paranoia, probabilistic reasoning, and need for closureRyan McKay
Macquarie Centre for Cognitive Science, Macquarie University, Sydney, Australia
Cogn Neuropsychiatry 12:362-76. 2007..It was hypothesised that patients with a history of persecutory delusions would display higher need for closure and a more extreme jumping to conclusions bias than healthy control ..
- A pilot study exploring the contribution of working memory to "jumping to conclusions" in people with first episode psychosisJohn Ormrod
Newcastle University, Newcastle upon Tyne, UK
Cogn Neuropsychiatry 17:97-114. 2012..The aim of the present study was to explore the contribution of working memory processes (WM) and IQ to hasty decision making and to investigate the stability of this bias over time...
- Can delusions be self-assessed? Concordance between self- and observer-rated delusions in schizophreniaTania Marie Lincoln
Section for Clinical Psychology and Psychotherapy, Faculty of Psychology, Philipps Universitat Marburg, Gutenbergstr 18, 35032 Marburg, Germany
Psychiatry Res 178:249-54. 2010..This study tested associations of self- and observer-rated delusions as well as factors associated with discrepancies...
- Schizophrenia and monothematic delusionsMax Coltheart
Macquarie Centre for Cognitive Science, Macquarie University, Sydney, NSW 2109, Australia
Schizophr Bull 33:642-7. 2007Numerous delusions have been studied which are highly specific and which can present in isolation in people whose beliefs are otherwise entirely unremarkable - "monothematic delusions" such as Capgras or Cotard delusions...
- Explaining delusions: a cognitive perspectiveVaughan Bell
Institute of Psychiatry, King s College London, Psychology Department Box 78, De Crespigny Park, London, SE5 8AF, UK
Trends Cogn Sci 10:219-26. 2006..Although delusions are commonly conceptualized as beliefs, not all models make reference to models of normal belief formation...
- Aberrant connectivity during self-other source monitoring in schizophreniaLiang Wang
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada, V6T 2A1
Schizophr Res 125:136-42. 2011....
- False memory in schizophrenia patients with and without delusionsReena Bhatt
School of Psychology, Cardiff University, Cardiff, UK
Psychiatry Res 178:260-5. 2010b>Delusions are fixed 'false beliefs' and, although a hallmark feature of schizophrenia, no previous study has examined if delusions might be related to 'false memories'...
- The contribution of a cognitive bias against disconfirmatory evidence (BADE) to delusions in schizophreniaTodd S Woodward
University Hospital Hamburg Eppendorf, Germany
J Clin Exp Neuropsychol 28:605-17. 2006..that provides a measure of a bias against disconfirmatory evidence (BADE), and its correspondence with delusions in people with schizophrenia and schizoaffective disorder was investigated...
- From real-world events to psychosis: the emerging neuropharmacology of delusionsPaul D Morrison
Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Schizophr Bull 35:668-74. 2009..Here, we discuss how the 3 modulators regulate learning within the striatum and how their dysfunction may lead to delusional thinking...
- The persistence of neuropsychiatric symptoms in dementia: the Cache County StudyMartin Steinberg
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Int J Geriatr Psychiatry 19:19-26. 2004..To estimate the 18-month persistence of neuropsychiatric symptoms in dementia in a population-based sample, and to compare the severity of neuropsychiatric symptoms at baseline to the severity at 18-month follow-up...
- Dimensional structure of psychotic symptoms: an item-level analysis of SAPS and SANS symptoms in psychotic disordersV Peralta
Psychiatric Unit, Virgen del Camino Hospital, Pamplona, Spain
Schizophr Res 38:13-26. 1999..explaining 64% of the total variance: poverty of affect/speech, thought disorder/inappropriate affect, bizarre delusions, social dysfunction, other delusions, paranoid delusions, bizarre behavior, nonauditory hallucinations, auditory ..
- The contribution of hypersalience to the "jumping to conclusions" bias associated with delusions in schizophreniaWilliam J Speechley
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
J Psychiatry Neurosci 35:7-17. 2010Previous schizophrenia research involving the "beads task" has suggested an association between delusions and 2 reasoning biases: (1) "jumping to conclusions" (JTC), whereby early, resolute decisions are formed on the basis of little ..
- Jumping to conclusions in delusional and non-delusional schizophrenic patientsSteffen Moritz
Universitatsklinikum Hamburg Eppendorf, Klinik fur Psychiatrie und Psychotherapie, Hamburg, Germany
Br J Clin Psychol 44:193-207. 2005Several studies have provided evidence for the claim that a subgroup of (schizophrenic) patients with current delusions share a jumping to conclusions (JTC) bias...
- 'Jumping to conclusions' and delusions in psychosis: relationship and response to treatmentMahesh Menon
Schizophrenia Program and PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Canada
Schizophr Res 98:225-31. 2008Jumping to conclusions' (JTC) on probabilistic reasoning tasks has been shown to be related with delusions in schizophrenia. However, whether JTC is merely correlated with, moderate or mediate delusions is not known...
- Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusionsFlorian Schlagenhauf
Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Mitte, Germany
Biol Psychiatry 65:1032-9. 2009Increased attribution of incentive salience to neutral or aversive stimuli might be associated with dysfunction of neuronal processing of positive and negative reinforcement and contribute to the formation of delusions in schizophrenia.
- Association between cannabis use and psychosis-related outcomes using sibling pair analysis in a cohort of young adultsJohn McGrath
Queensland Brain Institute, University of Queensland, St Lucia, Queensland, Australia
Arch Gen Psychiatry 67:440-7. 2010..The use of sibling pair analysis reduces the influence of unmeasured residual confounding...
- Jumping to conclusions and paranoid ideation in the general populationDaniel Freeman
Department of Psychology, Institute of Psychiatry, King s College London, UK
Schizophr Res 102:254-60. 2008An association of a 'jumping to conclusions' (JTC) reasoning style and delusions has been repeatedly found. The data-gathering bias has been particularly implicated with higher levels of delusional conviction in schizophrenia...
- The continuity of psychotic experiences in the general populationL C Johns
University of Manchester, UK
Clin Psychol Rev 21:1125-41. 2001..paper reviews evidence for the continuity of psychotic symptoms with normal experiences, focusing on the symptoms of hallucinations and delusions. It concludes by discussing the theoretical and treatment implications of such a continuum.
- The association between traumatic experience, paranoia and hallucinations: a test of the predictions of psychological modelsA Gracie
King s College London, Department of Psychology, Institute of Psychiatry, London, UK
Acta Psychiatr Scand 116:280-9. 2007..The current study investigated the relationship between trauma and predisposition to hallucinations and to paranoia in a non-clinical sample...
- Delusions of alien control in the normal brainS J Blakemore
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuropsychologia 41:1058-67. 2003b>Delusions of alien control, or passivity experiences, are symptoms associated with schizophrenia in which patients misattribute self-generated actions to an external source...
- Neural correlates of action attribution in schizophreniaChloe Farrer
Institut des Sciences Cognitives, 67 Boulevard Pinel, 69675 Bron Cedex, France
Psychiatry Res 131:31-44. 2004..The implications of these results for understanding pathological conditions such as schizophrenia are discussed...
- Midbrain activation during Pavlovian conditioning and delusional symptoms in schizophreniaLiana Romaniuk
University of Edinburgh, Royal Edinburgh Hospital, Scotland
Arch Gen Psychiatry 67:1246-54. 2010Recent theories have suggested that the inappropriate activation of limbic motivational systems in response to neutral stimuli may underlie the development of delusions in schizophrenia.
- The relevance of self-esteem and self-schemas to persecutory delusions: a systematic reviewMarie Luise Kesting
Section for Clinical Psychology and Psychotherapy, Department of Psychology, Philipps Universitat Marburg, Gutenbergstraße 18, 35032 Marburg, Germany Electronic address
Compr Psychiatry 54:766-89. 2013Self-esteem is frequently targeted in psychological approaches to persecutory delusions (PD)...
- A randomised controlled trial of a worry intervention for individuals with persistent persecutory delusionsChloe Foster
Department of Psychology, Institute of Psychiatry, King s College London, Denmark Hill, UK
J Behav Ther Exp Psychiatry 41:45-51. 2010..Therefore, the aim was to target worry in a therapeutic intervention for individuals with delusions. It was predicted that a worry intervention would reduce levels of worry and paranoia distress...
- The relationship between delusions and violence: findings from the East London first episode psychosis studyJeremy W Coid
Queen Mary University of London, Forensic Psychiatry Research Unit, Barts and the London School of Medicine and Dentistry, Wolfson Institute of Preventive Medicine, England
JAMA Psychiatry 70:465-71. 2013Psychotic persons who are violent often explain their violence as being due to delusions. However, research has failed to confirm associations between delusions and violent behavior.
- Effect of culture and environment on the phenomenology of delusions and hallucinationsKausar Suhail
Dept of Psychology, Govt College Lahore, Pakistan
Int J Soc Psychiatry 48:126-38. 2002..study was conducted to compare the influence of culture and immediate environment on the phenomenology of schizophrenic symptoms by examining the actual content of delusions and hallucinations in three groups of schizophrenic patients.
- The psychology of persecutory ideation II: a virtual reality experimental studyDaniel Freeman
Department of Psychology, Institute of Psychiatry, King s College London, London, United Kingdom
J Nerv Ment Dis 193:309-15. 2005A cognitive model of persecutory delusions is used to predict the occurrence of nonclinical paranoid thoughts in a virtual reality environment...
- Religious delusions in patients admitted to hospital with schizophreniaRonald Siddle
Department of Clinical Psychology, North Manchester General Hospital, Crumpsall, UK
Soc Psychiatry Psychiatr Epidemiol 37:130-8. 2002Religious delusions are clinically important because they may be associated with selfharm and poorer outcomes from treatment. They have not been extensively researched...
- Striatal lesions in delusional parasitosis revealed by magnetic resonance imagingMarkus Huber
Department of Psychiatry, General Hospital Bruneck, Spitalstrasse 4, 39031 Bruneck, Italy
Prog Neuropsychopharmacol Biol Psychiatry 32:1967-71. 2008..Systematic brain imaging studies are lacking. We aimed to identify a brain region with structural lesions in patients with DP in order to better understand the pathophysiology of DP...
- Old wine in new bottles? Stability and plasticity of the contents of schizophrenic delusionsT Stompe
University Hospital for Psychiatry Vienna, Vienna, Austria
Psychopathology 36:6-12. 2003..the last 20 years described a quick inclusion of new technologies and cultural innovations into schizophrenic delusions which led many of the authors to the conclusion that the 'Zeitgeist' is creating new delusional contents...
- Delusions and decision-making style: use of the Need for Closure ScaleDaniel Freeman
Department of Psychology, Institute of Psychiatry, King s College London, University of London, PO Box 77, Denmark Hill, London, SE5 8AF, UK
Behav Res Ther 44:1147-58. 2006..The aim of the study is to determine whether NFC has such a direct link with delusions. A secondary aim is to examine if NFC is related to the delusion-associated reasoning process of 'jumping to ..
- Cognitive factors maintaining persecutory delusions in psychosis: the contribution of depressionNatasha Vorontsova
Department of Psychology, Institute of Psychiatry, King s College London
J Abnorm Psychol 122:1121-31. 2013..study was to test whether depression and associated cognitive processes predict the maintenance of persecutory delusions. Three groups of participants were tested at baseline: 60 patients with persecutory delusions in the context of ..
- Delusions of Korean patients with Alzheimer's disease: study of drug-naïve patientsYong Tae Kwak
Department of Neurology, Hyoja Geriatric Hospital, Gyeonggi, Korea
Geriatr Gerontol Int 13:307-13. 2013Although delusions are one of the most prominent psychiatric symptoms in Alzheimer's disease (AD), research on the subtypes, prevalence and associated factors of delusions, especially in drug (psychotropic)-naïve patients, has been ..
- Why do people with delusions fail to choose more realistic explanations for their experiences? An empirical investigationDaniel Freeman
Department of Psychology, Institute of Psychiatry, King s College London, University of London, London, United Kingdom
J Consult Clin Psychol 72:671-80. 2004b>Delusions can be viewed as explanations of experiences,. By definition, the experiences are insufficient to merit the delusional explanations...
- Disrupted prediction-error signal in psychosis: evidence for an associative account of delusionsP R Corlett
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
Brain 130:2387-400. 2007b>Delusions are maladaptive beliefs about the world...
- Differences in cognitive and emotional processes between persecutory and grandiose delusionsPhilippa A Garety
Department of Psychology, Institute of Psychiatry, King s College London, PO77, Henry Wellcome Building, De Crespigny Park, London SE5 8AF, UK
Schizophr Bull 39:629-39. 2013..propose that cognitive and emotional processes, in the context of anomalies of experience, lead to and maintain delusions. No large-scale studies have investigated whether persecutory and grandiose delusions reflect differing ..
- Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorderFrancesco Benedetti
Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
J Affect Disord 125:341-4. 2010..Previous studies in bipolar patients reported non-significant trends in the same direction...
- The neuropsychology of delusionsMax Coltheart
Macquarie Centre for Cognitive Science, Macquarie University, Sydney, NSW, Australia
Ann N Y Acad Sci 1191:16-26. 2010..studies in this context suggest that the region of the brain specifically involved in hypothesis evaluation (and therefore, according to the two-factor theory, impaired in people with delusions) is the right lateral prefrontal cortex.
- Relationship between delusions and regional cerebral blood flow in Alzheimer's diseaseSeigo Nakano
Department of Internal Medicine, Fukuoka University, Fukuoka, Japan
Dement Geriatr Cogn Disord 21:16-21. 2006To investigate the association between delusions and cerebral functional deficits in Alzheimer's disease (AD), we evaluated probable AD patients with and without delusions.
- What happened to the voices? A fine-grained analysis of how hallucinations and delusions change under psychiatric treatmentSophia D Schneider
University Medical Center Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martinistr 52, Hamburg, Germany
Psychiatry Res 188:13-7. 2011..Rating Scales (PSYRATS) have demonstrated their usefulness for the dimensional assessment of hallucinations and delusions. However, there is no evaluated German version of the PSYRATS to date...
- Change in delusions is associated with change in "jumping to conclusions"Todd S Woodward
Department of Psychiatry, University of British Columbia, Vancouver, Canada
Psychiatry Res 170:124-7. 2009..that premature termination of data collection and jumping to conclusions behavior (JTC) is associated with delusions. However, few investigations have attempted to track associations between changes in delusions and changes in ..
- Deficits in sensory prediction are related to delusional ideation in healthy individualsChristoph Teufel
Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, University of Cambridge, Cambridge, UK
Neuropsychologia 48:4169-72. 2010..processes in schizophrenic patients and these low-level deficits are thought to contribute to the emergence of delusions of control...
- A cognitive bias against disconfirmatory evidence (BADE) is associated with schizotypyLisa Buchy
Department of Research, Riverview Hospital, Coquitlam, B C, Canada V3C 4J2
Schizophr Res 90:334-7. 2007..This result provides support for the "schizophrenia spectrum" account of psychosis...
- Attentional modulation of external speech attribution in patients with hallucinations and delusionsLana Marija Ilankovic
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
Neuropsychologia 49:805-12. 2011A range of psychological theories have been proposed to account for the experience of auditory hallucinations and delusions in schizophrenic patients...
- Misattribution of external speech in patients with hallucinations and delusionsPaul P Allen
Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, P O BOX 67, Denmark Hill, London SE5 8AF, UK
Schizophr Res 69:277-87. 2004..We examined whether patients with hallucinations and delusions would demonstrate an externalising bias on a task that did not involve cognitive self-monitoring.
- Cognitive and emotional predictors of predisposition to hallucinations in non-patientsAnthony P Morrison
Psychology Services, Mental Health Services of Salford, UK
Br J Clin Psychol 41:259-70. 2002..We aimed to test the specific hypothesis that positive interpretations of voices would predict frequency of hallucinatory experiences...
- Why we need more debate on whether psychotic symptoms lie on a continuum with normalityA S David
Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College, London, UK
Psychol Med 40:1935-42. 2010..Finding the distinctive characteristics of psychotic phenomena in people with clinical disorders, in addition to their origins in 'normal' cognitive processes, is a worthwhile goal...
- Persecutory ideation and insomnia: findings from the second British National Survey of Psychiatric MorbidityDaniel Freeman
King s College London, Department of Psychology, PO Box 077, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK
J Psychiatr Res 44:1021-6. 2010..The results are consistent with recent developments in the cognitive understanding of persecutory delusions, in which insomnia, negative affect, and substance use are identified as key factors...
- Alteration of rCBF in Alzheimer's disease patients with delusions of theftR Fukuhara
Department of Neuropsychiatry, Ehime University School of Medicine, Shigenobu-chou, Onsen-gun, Ehime 791-0295, Japan
Neuroreport 12:2473-6. 2001..Nine AD patients with only one type of delusion (delusions of theft) and nine age, cognitive function-matched AD patients without any type of delusions were selected from ..
- Neuroimaging of delusions in Alzheimer's diseaseZahinoor Ismail
Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario, Canada
Psychiatry Res 202:89-95. 2012..searched using the keywords "imaging", "neuroimaging", "CT", "MRI", "PET", "SPECT", "Alzheimer's", "dementia", "delusions" and "psychosis" to find studies specifically assessing or reporting on neuroimaging of delusions in Alzheimer's ..
- Perceptions of hostility by persons with and without persecutory delusionsDennis R Combs
Department of Psychology, University of Texas at Tyler, Tyler, TX 75799, USA
Cogn Neuropsychiatry 14:30-52. 2009..cues regarding the intentions of others are lacking, may be perceived as hostile by persons with persecutory delusions (PD). Thus, a social-cognitive bias for the perception of hostility may be present...
- Abductive inference and delusional beliefMax Coltheart
Centre for Cognitive Science, Macquarie University, Sydney, NSW 2019, Australia
Cogn Neuropsychiatry 15:261-87. 2010..Second, we argue that in relation to many delusions (we consider seven) one can clearly identify what the abnormal cognitive data are which prompted the delusion ..
- Delusions of Japanese patients with Alzheimer's diseaseManabu Ikeda
Department of Neuropsychiatry, Ehime University School of Medicine, Ehime, Japan
Int J Geriatr Psychiatry 18:527-32. 2003b>Delusions constitute one of the most prominent psychiatric complications in Alzheimer's disease (AD). However, there is little consensus of the prevalence and associated factors for delusions in AD.
- Are screening instruments valid for psychotic-like experiences? A validation study of screening questions for psychotic-like experiences using in-depth clinical interviewIan Kelleher
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
Schizophr Bull 37:362-9. 2011..Our results suggest that it may be possible to screen the general adolescent population for psychotic-like experiences with a high degree of accuracy using a short self-report questionnaire...
- The Psychotic Symptom Rating Scales (PSYRATS): their usefulness and properties in first episode psychosisRichard Drake
Division of Psychiatry, University of Manchester, 2nd Floor Education and Research Centre, Wythenshawe Hospital, Manchester, M23 9PL, United Kingdom
Schizophr Res 89:119-22. 2007..The PSYRATS have been shown to assess dimensions of hallucination and delusions reliably and validly in chronically psychotic patients but not in first episode patients...
- Are theory of mind deficits in understanding intentions of others associated with persecutory delusions?Stephanie Mehl
Department of Psychiatry, Rheinische Friedrich Wilhelms University, Bonn, Germany
J Nerv Ment Dis 198:516-9. 2010..of this study was to investigate the association of the Theory of Mind ability to infer intentions of others and delusions in patients with schizophrenia-spectrum disorders...
- Belief inflexibility in schizophreniaTodd S Woodward
Department of Psychiatry, University of British Columbia, and BC Mental Health and Addictions Research Institute, PHSA Research and Networks, Vancouver, BC, Canada
Cogn Neuropsychiatry 13:267-77. 2008..using delusion-neutral material have demonstrated that patients with schizophrenia, particularly those with delusions, display a bias against disconfirmatory evidence (BADE)...
- Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer diseaseSuzanne Reeves
Section of Old Age Psychiatry, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, De Crespigny Park, Camberwell, London SE5 8AF, UK
Neurology 72:528-34. 2009..This study aimed to test the hypothesis that the symptom domains delusions and apathy would be associated with striatal dopamine (D2) receptor function in AD.
- Relationship between hallucinations, delusions, and rapid eye movement sleep behavior disorder in Parkinson's diseaseClaudio Pacchetti
Parkinson s Disease and Movement Disorders Unit, IRCCS C Mondino Institute of Neurology, Pavia, Italy
Mov Disord 20:1439-48. 2005..of the subjects presented with psychotic disorders; 30% (n = 86) had experienced hallucinations; 2% (n = 6) had delusions without hallucinations. Sixty-two (72%) hallucinators reported nocturnal hallucinations. A total of 6...
- ApoE epsilon4 allele is associated with incidental hallucinations and delusions in patients with ADJ B Chang
Department of Neurology, National Yang Ming University School of Medicine, Taipei County, Taiwan
Neurology 63:1105-7. 2004..The presence of the ApoE epsilon4 allele carried a 19.0-fold risk for developing hallucinations and a 3.4-fold risk for delusions.
- Demographic correlates of psychotic-like experiences in young Australian adultsJ Scott
Child and Youth Mental Health Service, Royal Children s Hospital, Herston, Australia
Acta Psychiatr Scand 118:230-7. 2008..Psychotic-like experiences (PLE) in the general community are common. The aims of this study were to examine the prevalence and demographic correlates of PLE in young adults...
- Delusions in frontotemporal lobar degenerationRohani Omar
Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
J Neurol 256:600-7. 2009We assessed the significance and nature of delusions in frontotemporal lobar degeneration (FTLD), an important cause of young-onset dementia with prominent neuropsychiatric features that remain incompletely characterised...
- Delusions and processing of discrepant information: an event-related brain potential studyJ Bruno Debruille
Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
Schizophr Res 89:261-77. 2007One possible explanation for why delusions persist despite the awareness of contradictory information is that the new information fails to be integrated...
- Delusions and hallucinations are associated with worse outcome in Alzheimer diseaseNikolaos Scarmeas
Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, New York, NY 10032, USA
Arch Neurol 62:1601-8. 2005b>Delusions and hallucinations are common in Alzheimer disease (AD) and there are conflicting reports regarding their ability to predict cognitive decline, functional decline, and institutionalization...
- Delusional infestation, including delusions of parasitosis: results of histologic examination of skin biopsy and patient-provided skin specimensSara A Hylwa
Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Arch Dermatol 147:1041-5. 2011To review the results of skin biopsies and patient-provided specimens from patients whose assessment was consistent with delusional infestation, including delusions of parasitosis.
- Measuring delusional ideation: the 21-item Peters et al. Delusions Inventory (PDI)Emmanuelle Peters
Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
Schizophr Bull 30:1005-22. 2004..Norms are reported for a new 21-item version of the Peters et al. Delusions Inventory (PDI; Peters et al. 1999b)...
- The self in action: lessons from delusions of controlChris Frith
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, UK
Conscious Cogn 14:752-70. 2005Patients with delusions of control are abnormally aware of the sensory consequences of their actions and have difficulty with on-line corrections of movement. As a result they do not feel in control of their movements...
- A generalized bias against disconfirmatory evidence in schizophreniaSteffen Moritz
University of Hamburg, University Hospital of Psychiatry, Germany
Psychiatry Res 142:157-65. 2006Fixation onto false/unrealistic beliefs is a core feature of schizophrenic delusions. A recent study conducted by our research group has provided evidence for the presence of a bias against disconfirmatory evidence (BADE) in patients ..
- Do antipsychotics improve reasoning biases? A reviewSuzanne H So
Department of Psychology, Institute of Psychiatry, King s College London, London, United Kingdom
Psychosom Med 72:681-93. 2010..Patients with schizophrenia, especially those with delusions, show not only cognitive deficits but also "reasoning biases," namely, "jumping to conclusions," reduced belief ..
- Genetics and Haloperidol ResponseRobert J Hitzemann; Fiscal Year: 2012..Current treatment, while generally effective for reducing positive psychotic symptoms(delusions, hallucinations, thought disorder) frequently leads to a number of untoward side-effects...
- A multi-faceted approach to epigenomic profiling in Alzheimer's disorderJonathan Mill; Fiscal Year: 2012..seen in AD, many patients exhibit a range of non-cognitive symptoms that include depression, aggression, delusions and hallucinations...
- Serotonergic modulation of claustro-cortical circuitsJay A Gingrich; Fiscal Year: 2013..in these brain functions offers possible insight into the symptoms of disorganization, hallucinations, delusions, lack of relatedness, involution, distractedness, and cognitive decline that characterize these disorders...
- Structural and Functional Alterations of Interneurons in Models of SchizophreniaIstvan Mody; Fiscal Year: 2012..treatments for schizophrenia are most effective in treating positive symptoms, comprising hallucinations and/or delusions. However, such antipsychotics yield little amelioration of the burden of negative symptoms and cognitive ..
- In vitro tools for preclinical analysis of cognitive therapies for schizophreniaKRISTEN RICHARDSON; Fiscal Year: 2012..Symptoms of schizophrenia are classified into three categories: positive (delusions and hallucinations), negative (flattened affect, social isolation) and cognitive (impaired attention, executive ..
- Mechanism-based, pro-cognitive therapies for schizophreniaDAVID JULIAN GERBER; Fiscal Year: 2010..Symptoms of schizophrenia can be grouped into three categories: positive symptoms, including hallucinations and delusions;negative symptoms, such as social isolation and flattened affect;and cognitive symptoms, which include impaired ..
- Influence of Psychosis on Brain-Behavior Endophenotypes for Bipolar DisorderDavid C Glahn; Fiscal Year: 2012..and neuroimaging endophenotypes for the disorder must account for the potential impact of hallucinations and delusions on these markers...
- First-Episode Psychosis and Pre-Onset Cannabis UseMichael T Compton; Fiscal Year: 2012..e., hallucinations and delusions), and the nature of negative, cognitive, neurological, and positive symptoms of schizophrenia...
- GABAergic and Reelin Deficits in SchizophreniaSEYYED HOSSEIN FATEMI; Fiscal Year: 2013..e., apathy, poor or nonexistent social functioning) and positive (presence of hallucinations, delusions) symptoms, and a lifetime prevalence of 1%...
- Plasticity-Based Adaptive Cognitive Remediation for SchizophreniaHENRY WILTSHIRE MAHNCKE; Fiscal Year: 2010..challenges in functional abilities were caused by the overt symptoms of schizophrenia, like hallucinations and delusions;however research has now shown that these challenges are largely a result of problems with cognitive abilities, ..
- Towards understanding cellular mechanisms of positive symptoms of schizophreniaStanislav S Zakharenko; Fiscal Year: 2013..the world's population and is characterized by a constellation of symptoms that include hallucinations and delusions (positive symptoms), antisocial behavior and blunted emotions (negative symptoms), deficits in working memory, ..
- Engrafting human neurons into animal models to study schizophreniaKrishnan Padmanabhan; Fiscal Year: 2013..is a debilitating psychiatric disorder characterized by an array of symptoms including hallucinations, delusions, difficulty expressing emotions, and deficits in attention and memory...
- Microstructural Characterization of White Matter in SchizophreniaMariana Lazar; Fiscal Year: 2010Schizophrenia is a chronic, severe, and disabling disorder that is characterized by hallucinations, delusions, and motor deficits...
- Using fMRI to Measure Negative Symptoms in SchizophreniaEDWARD E contact SMITH; Fiscal Year: 2010..Schizophrenia, a devastating psychiatric disorder, is chiefly characterized by positive symptoms, such as delusions and hallucinations, and negative symptoms, such as anhedonia (lack of pleasure), avolition (lack of willed-..
- Identifying the clinicopathologic basis of dementia-related psychosisKatherine P Rankin; Fiscal Year: 2013..datasets to identify the clinical phenomenology, neuroanatomy, and neuropathology underlying different types of delusions and hallucinations in three diseases of aging: Alzheimer's disease (AD), behavioral variant frontotemporal ..
- Schizophrenia Pharmacogenetics: cognition and symptom response to antipsychoticsJeffrey R Bishop; Fiscal Year: 2013..Psychotic symptoms like hallucinations and delusions that occur with this disease often respond well to antipsychotic agents like risperidone...
- Control of Attention by Working MemorySteven J Luck; Fiscal Year: 2013..Although hallucinations and delusions are the most salient symptoms of this disease, schizophrenia also involves pervasive cognitive deficits that are ..
- Optimization of Novel NR2C and NR2D subunit-selective NMDA receptor potentiatorsKAMALESH RUPPA; Fiscal Year: 2013..Current therapies to treat this disorder have been effective in ameliorating positive symptoms (hallucinations, delusions, irrational fear), but are less effective in controlling negative symptoms (social withdrawal, anhedonia) and ..
- Dextras1, Brain Iron Homeostasis and Mental HealthSangwon F Kim; Fiscal Year: 2010Schizophrenia is commonly recognized by its psychotic symptoms such as delusions and hallucinations, which often leads to social and functional impairment...
- Prediction of Psychosis in Alzheimer DiseaseRobert A Sweet; Fiscal Year: 2013DESCRIPTION (provided by applicant): Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer Disease (AD+Psychosis, AD+P), affecting ~ 40% to 60% of individuals with AD...
- The Neural Basis of Delusions in Schizophrenia: Studies of Emotional PerceptionDaphne J Holt; Fiscal Year: 2010..application for an NIMH Patient-Oriented Research Career Development Award (K-23) entitled "The Neural Basis of Delusions in Schizophrenia: Studies of Emotional Perception...
- Novel serotonergic, pro-cognitive antipsychotic therapiesSilvana Leit; Fiscal Year: 2012..The symptoms of schizophrenia can be grouped into three major categories: positive (e.g. hallucinations and delusions), negative (e.g. social isolation and inappropriate emotional response), and cognitive symptoms...
- Evaluation of Mouse Hallucinations by fMRIPaul H Patterson; Fiscal Year: 2012..gating, it is said to be impossible to evaluate the positive symptoms of schizophrenia, hallucinations and delusions. Thus, this disorder is often considered to be "uniquely human"...
- Dcycloserine Augmentation of Cognitive Behavioral Therapy for DelusionsDonald C Goff; Fiscal Year: 2013DESCRIPTION (provided by applicant): Antipsychotic-resistant delusions are common in schizophrenia and are frequently responsible for incarceration and self injury...
- Corollary Discharge Dysfunction in Schizophrenia: ERPs and EEGJudith M Ford; Fiscal Year: 2012..It may also contribute to symptoms such as hallucinations, delusions, and even the desire to engage with people and in activities...
- Clinical and Computational Studies of Dopamine Function in SchizophreniaJames M Gold; Fiscal Year: 2013..deficits and negative symptoms than it is with the positive symptoms of the illness including hallucinations and delusions. Negative symptoms are generally defined as the absence of normal function, but the actual mechanisms involved ..
- Quantitative Behavioral and Imaging Phenotypes of Amotivation in SchizophreniaDaniel H Wolf; Fiscal Year: 2013..Unlike positive symptoms (hallucinations, delusions) which are generally responsive to antipsychotic medications, negative symptoms including amotivation respond ..
- Anxiolytic Property of Atypical AntipsychoticsMing Li; Fiscal Year: 2009..Although both groups show similar efficacy against psychosis (e.g., delusions, hallucinations), it is unclear whether atypicals as a class have intrinsic and superior benefits over typicals ..
- Molecular biology of mesocortical and mesoaccumbens dopamine neuronsJEFFREY EELLS; Fiscal Year: 2009..dopamine neurotransmission contributing to positive symptoms of schizophrenia (paranoia, hallucinations, delusions, and bizarre behavior) and attenuated mesocortical dopamine neurotransmission affecting negative symptoms (..
- Cognitive Control and Language Impairments in SchizophreniaTamara Y Swaab; Fiscal Year: 2013..Although hallucinations and delusions are the most salient symptoms of this disease, language abnormalities are among the most prominent cognitive ..
- Subtype Specific Agonists for D1-D5 Dopamine ReceptorsWilliam Goddard; Fiscal Year: 2007..Dopamine receptor antagonists have been developed to block hallucinations and delusions that occur in schizophrenic patients, whereas dopamine receptor agonists are effective in alleviating the ..
- Antipsychotic Treatment Effects on Attention &Working Memory in SchizophreniaJames L Reilly; Fiscal Year: 2013..in antipsychotic pharmacotherapy have resulted in important gains for treating symptoms of hallucinations and delusions, cognitive deficits have been far less responsive to standard treatments...
- SIGMA LIGAND ELECTROPHYSIOLOGY IN RAT HIPPOCAMPAL SLICEChristine Eccles; Fiscal Year: 1991..At appropriate doses, however, they can cause psychotomimetic effects such as delusions, hallucination, depersonalization and dysphoria which are not blocked by the mu/kappa opiate antagonist naloxone...
- Longitudinal Imaging of Patients at Clinical Risk for Psychosis.Scott A Small; Fiscal Year: 2013..with schizophrenia itself, related to the severity of positive psychotic symptoms across illness stages such as delusions, and predicted progression to psychosis from a prodromal or clinical high-risk state in a small cohort (Schobel, ..
- PARTIAL DOPAMINEAGONIST TREATMENT OF SCHIZOPHRENIACarol Tamminga; Fiscal Year: 2002..of these three aims will be evaluated in the three primary symptom cluster of schizophrenia: 1) hallucinations/delusions; 2) disorganization, and 3) negative symptoms, and on cognitive function...
- EPILEPSY AS A NEUROLOGICAL MODEL OF SCHIZOPHRENIALaura Marsh; Fiscal Year: 2000..be tested: Hypothesis 1: ESZ and ISZ will demonstrate similar profiles of positive symptoms (hallucinations, delusions, and thought disorder) and negative symptoms (e.g...
- DNA EXPANSION IN SCHIZOPHRENIACynthia McMurray; Fiscal Year: 2000..from applicant's abstract): Schizophrenia is a severe disorder characterized by psychotic symptoms such as delusions and hallucinations and/or debilitating behavioral symptoms...
- Understanding Delusions: Aberrant Salience and Defensive Self-ProcessingDAVID COLIN CICERO; Fiscal Year: 2010..g., low self-concept clarity) may be related to delusions in schizophrenia. However, the mechanisms that underlie anomalous experiences have been largely unexplored...
- SCHIZOPHRENIC COGNITION: A LONGITUDINAL STUDYMartin Harrow; Fiscal Year: 1992..phase, during partial recovery, and are being followed up at various phases during the posthospital period, for delusions, hallucinations, disordered thinking, and negative symptoms...
- Cognitive Treatments of Hallucinations in SchizophreniaSandra Wilkniss; Fiscal Year: 2005..are not responsive to antipsychotic medication and continue to suffer from distressing positive symptoms such as delusions and hallucinations...
- A thyroid receptor co-activator hypothesis for psychosisRobert Philibert; Fiscal Year: 2005..S. population and is characterized by the presence of hallucinations and delusions. Genetic factors are thought to account for the majority of the vulnerability to illness for this syndrome...
- DEVICE AND METHOD FOR BIOMARKERS IN SCHIZOPHRENIAGeorge Hu; Fiscal Year: 2009..a biomarker for schizophrenia, which is a severe, heterogeneous mental disorder that leads to hallucinations and delusions, social withdrawal, and cognitive decline...
- Ampakines in SchizophreniaSteven Johnson; Fiscal Year: 2002..Applicant's Abstract) Currently available antipsychotics effectively control positive symptoms (hallucinations, delusions), but persistent negative symptoms (withdrawal, apathy) and cognitive deficits are little affected and can be ..
- Computerized Interactive Assessment of Functional Skills for Schizophrenia Drug TKOLLEEN HURLEY; Fiscal Year: 2009..2000). Unfortunately, while current antipsychotic treatments control the delusions and hallucinations found in people with schizophrenia, these drugs are unable to provide more than minimal ..
- Neural Patterns of Visual Learning in SchizophreniaNicola Cascella; Fiscal Year: 2006..multiple symptom manifestations that cluster into at three domains: (1) reality distortion (hallucinations and delusions), (2) negative symptoms (psychomotor retardation), and (3) disorganization (thought disorder)...
- SCHIZOPHRENIC COGNITION--A LONGITUDINAL STUDYMartin Harrow; Fiscal Year: 2001..phase, during partial recovery, and are being followed up at various phases during the posthospital period, for delusions, hallucinations, disordered thinking, and negative symptoms...
- DELUSIONS AND CEREBRAL METABOLISM IN ALZHEIMERS DISEASEDavid Sultzer; Fiscal Year: 2001..b>Delusions are common in patients with AD and contribute substantially to behavioral disturbances and other morbid aspects ..
- fMRI Localization of Psychotic Symptoms in SchizophreniaDavid Silbersweig; Fiscal Year: 2005..Psychosis, consisting of the symptoms of delusions and- hallucinations, represents the most striking and severe part of the psychiatric symptom spectrum, and ..
- Neural Correlates of Source Monitoring in SchizophreniaAnthony Weiss; Fiscal Year: 2007..eventual goal of examining the role of these faulty cognitive processes in the production of hallucinations and delusions. In addition to the proposed research described below, the candidate seeks training in functional neuroimaging ..
- EFFECTS OF AGING ON MEMORY FOR SOURCE OF INFORMATIONMarcia Johnson; Fiscal Year: 2003..where, to potential increased vulnerability to false memories in eyewitness situations or to the development of delusions. The proposed research focuses on the retrieval and evaluation phase of episodic remembering (source monitoring)...
- GERIATRIC MAJOR DEPRESSION AND DELUSIONSBarnett Meyers; Fiscal Year: 1991..unipolar major depressives will be separated into three clinical groups based upon presence and type of delusions: mood-congruent delusional depressives; mood- incongruent delusional depressives; and depressives without ..
- Neuroanatomy of Emotion in Treatment Resistant PsychosisStephan Taylor; Fiscal Year: 2006..We hypothesize that positive symptoms of psychosis involve the inappropriate attribution of salience, such as delusions of reference, while negative symptoms involve a failure to respond to emotional stimuli...
- TREATMENT AND OUTCOME OF EARLY ONSET BIPOLAR DISORDERVivian Kafantaris; Fiscal Year: 2005..In adolescents, bipolar disorder is often accompanied by delusions, hallucinations, or severe assaultive or destructive behaviors that require acute treatment with adjunctive ..
- NEUROPSYCHOLOGY OF PSYCHOSIS IN ALZHEIMERS DISEASEJane Paulsen; Fiscal Year: 2000..Until research finds a means of treating AD with curative measures, symptoms such as delusions and hallucinations must be aggressively identified, diagnosed, and managed...
- Cannabinoids and cortical-cerebellar functionSachin Patel; Fiscal Year: 2005Cannabis intoxication is known to produce psychotic symptoms such as delusions, and disorganized thoughts resembling schizophrenia...
- LANGUAGE DISTURBANCE IN SCHIZOPHRENIAWilliam Sledge; Fiscal Year: 1991..impatient and one outpatient; two groups of affective disorder (major depression with mood congruent delusions) patients - one inpatient and one outpatient; and a group of non-psychiatric volunteers...
- Semantic processing in schizophrenia: Symptoms & memoryJOSCELYN FISHER; Fiscal Year: 2005Positive symptoms, such as delusions and thought disorder, are some of the most puzzling aspects of schizophrenia...
- Emotional Awareness and Peculiar BeliefsMATTHEW BODEN; Fiscal Year: 2006..emotions/emotional processes, interact with which (b) cognitive biases (previously found to be associated with delusions), and with which (c) individual differences (e.g...
- Epigenetic Variation and its Determinants in DepressionJames Potash; Fiscal Year: 2008..Results from the novel studies proposed in this application should shed light on the epigenetic mechanisms and gene-environment interactions that result in vulnerability to depression. ..
- Genetic Linkage and Association in Bipolar DisorderJames Potash; Fiscal Year: 2009..These new variants would then be tested for association in our sample. The important findings that have already emerged from our very carefully assessed sample argue for the benefits of extending this valuable resource. ..
- Neural Network Models of LanguageRalph Hoffman; Fiscal Year: 2005..such as derailment and illogicality), (II) negative thought disorder (reduced language outputs), and (III) delusions of the idee fixe type...
- rTMS Clinical Trial for Auditory HallucinationsRALPH EDWARD HOFFMAN; Fiscal Year: 2010..This study will provide critical information regarding positioning strategies that optimize rTMS for AHs, as well as new insights regarding underlying pathophysiology. ..
- Depression in Alzheimer's Disease Study 2 (DIADS-2)Constantine Lyketsos; Fiscal Year: 2007..unreadable] [unreadable]..