delusions

Summary

Summary: A false belief regarding the self or persons or objects outside the self that persists despite the facts, and is not considered tenable by one's associates.

Top Publications

  1. pmc Toward a neurobiology of delusions
    P R Corlett
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Centre, Abraham Ribicoff Research Facility, 34 Park Street, New Haven, CT 06519, USA
    Prog Neurobiol 92:345-69. 2010
  2. ncbi Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia
    Shitij Kapur
    Clarke Division of the Centre for Addiction and Mental Health, 250 College St, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 160:13-23. 2003
  3. ncbi The past and future of delusions research: from the inexplicable to the treatable
    P A Garety
    P A Garety, MA, MPhil, MA Ed, PhD, FBPsS, Department of Psychology, Institute of Psychiatry, King s College London D Freeman, PhD, DClinPsy, CPsychol, FBPsS, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Br J Psychiatry 203:327-33. 2013
  4. ncbi The cognitive and affective structure of paranoid delusions: a transdiagnostic investigation of patients with schizophrenia spectrum disorders and depression
    Richard P Bentall
    School of Psychology, Adeilad Brigantia Bldg, Penrallt Road, Gwynedd, Wales
    Arch Gen Psychiatry 66:236-47. 2009
  5. ncbi A cognitive model of persecutory delusions
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, UK
    Br J Clin Psychol 41:331-47. 2002
  6. ncbi Evidence for sensory prediction deficits in schizophrenia
    Sukhwinder S Shergill
    Institute of Neurology, University College London
    Am J Psychiatry 162:2384-6. 2005
  7. ncbi Emotions, self-esteem, and paranoid episodes: an experience sampling study
    Viviane Thewissen
    Open University of the Netherlands, Heerlen
    Br J Clin Psychol 50:178-95. 2011
  8. ncbi Connecting neurosis and psychosis: the direct influence of emotion on delusions and hallucinations
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, University of London, Denmark Hill, London SE5 8AF, UK
    Behav Res Ther 41:923-47. 2003
  9. ncbi Suspicious minds: the psychology of persecutory delusions
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, Denmark Hill, London, UK
    Clin Psychol Rev 27:425-57. 2007
  10. ncbi Reasoning, emotions, and delusional conviction in psychosis
    Philippa A Garety
    Department of Psychology, Institute of Psychiatry, King s College London, London, England
    J Abnorm Psychol 114:373-84. 2005

Detail Information

Publications340 found, 100 shown here

  1. pmc Toward a neurobiology of delusions
    P R Corlett
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Centre, Abraham Ribicoff Research Facility, 34 Park Street, New Haven, CT 06519, USA
    Prog Neurobiol 92:345-69. 2010
    b>Delusions are the false and often incorrigible beliefs that can cause severe suffering in mental illness. We cannot yet explain them in terms of underlying neurobiological abnormalities...
  2. ncbi Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia
    Shitij Kapur
    Clarke Division of the Centre for Addiction and Mental Health, 250 College St, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 160:13-23. 2003
    ..The objective of this overview is to link the neurobiology (brain), the phenomenological experience (mind), and pharmacological aspects of psychosis-in-schizophrenia into a unitary framework...
  3. ncbi The past and future of delusions research: from the inexplicable to the treatable
    P A Garety
    P A Garety, MA, MPhil, MA Ed, PhD, FBPsS, Department of Psychology, Institute of Psychiatry, King s College London D Freeman, PhD, DClinPsy, CPsychol, FBPsS, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Br J Psychiatry 203:327-33. 2013
    Problems with the diagnosis and treatment of schizophrenia have led for a call to change strategy and focus on individual psychotic experiences. In recent years, research on delusions has led the way.
  4. ncbi The cognitive and affective structure of paranoid delusions: a transdiagnostic investigation of patients with schizophrenia spectrum disorders and depression
    Richard P Bentall
    School of Psychology, Adeilad Brigantia Bldg, Penrallt Road, Gwynedd, Wales
    Arch Gen Psychiatry 66:236-47. 2009
    Paranoid delusions are a common symptom of a range of psychotic disorders...
  5. ncbi A cognitive model of persecutory delusions
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, UK
    Br J Clin Psychol 41:331-47. 2002
    A multifactorial model of the formation and maintenance of persecutory delusions is presented. Persecutory delusions are conceptualized as threat beliefs...
  6. ncbi Evidence for sensory prediction deficits in schizophrenia
    Sukhwinder S Shergill
    Institute of Neurology, University College London
    Am J Psychiatry 162:2384-6. 2005
    Patients with schizophrenia experiencing delusions and hallucinations can misattribute their own actions to an external source...
  7. ncbi Emotions, self-esteem, and paranoid episodes: an experience sampling study
    Viviane Thewissen
    Open University of the Netherlands, Heerlen
    Br J Clin Psychol 50:178-95. 2011
    ..Clinicians need to be aware of the central role of emotion-related processes and especially self-esteem in paranoid thinking...
  8. ncbi Connecting neurosis and psychosis: the direct influence of emotion on delusions and hallucinations
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, University of London, Denmark Hill, London SE5 8AF, UK
    Behav Res Ther 41:923-47. 2003
    ..Psychological theories and experimental evidence concerning the influence of emotion on the content and form of delusions and hallucinations are therefore reviewed...
  9. ncbi Suspicious minds: the psychology of persecutory delusions
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, Denmark Hill, London, UK
    Clin Psychol Rev 27:425-57. 2007
    At least 10-15% of the general population regularly experience paranoid thoughts and persecutory delusions are a frequent symptom of psychosis. Persecutory ideation is a key topic for study...
  10. ncbi Reasoning, emotions, and delusional conviction in psychosis
    Philippa A Garety
    Department of Psychology, Institute of Psychiatry, King s College London, London, England
    J Abnorm Psychol 114:373-84. 2005
    ..One hundred participants with current delusions, recruited for a treatment trial of psychological therapy (PRP trial), were assessed at baseline on measures of ..
  11. pmc Targeting reasoning biases in delusions: a pilot study of the Maudsley Review Training Programme for individuals with persistent, high conviction delusions
    Helen Waller
    Institute of Psychiatry, King s College London, P O Box P077, 16 De Crespigny Park, London SE5 8AF, UK
    J Behav Ther Exp Psychiatry 42:414-21. 2011
    b>Delusions are often resistant to change, persisting despite successful antipsychotic treatment or Cognitive Behavioural Therapy...
  12. ncbi Impact of state anxiety on the jumping to conclusions delusion bias
    Suzanne Ho Wai So
    Department of Psychology, Institute of Psychiatry, King s College, London, London, UK
    Aust N Z J Psychiatry 42:879-86. 2008
    ..This is the first study to investigate the relationship between the level of state anxiety and the jumping to conclusions (JTC) reasoning bias in patients with first-episode psychosis using an experimental manipulation procedure...
  13. ncbi The psychological effect of an urban environment on individuals with persecutory delusions: the Camberwell walk study
    Lyn Ellett
    Department of Psychology, Institute of Psychiatry, King s College London, University of London, UK
    Schizophr Res 99:77-84. 2008
    ..and clinical effects of exposure to one specific deprived urban environment on individuals with persecutory delusions. It was predicted that the urban environment would affect emotional and reasoning processes highlighted in a ..
  14. ncbi Developing treatments of persistent persecutory delusions: the impact of an emotional processing and metacognitive awareness intervention
    Claire Hepworth
    Department of Psychology, Institute of Psychiatry, King s College London, London
    J Nerv Ment Dis 199:653-8. 2011
    Worry has been implicated in increasing the levels of distress associated with persecutory delusions. It may partly cause this distress via the impediment of emotional processing of upsetting experiences...
  15. pmc Evidence that onset of psychosis in the population reflects early hallucinatory experiences that through environmental risks and affective dysregulation become complicated by delusions
    Feikje Smeets
    Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands
    Schizophr Bull 38:531-42. 2012
    To examine the hypothesis that the "natural" combination of delusions and hallucinations in psychotic disorders in fact represents a selection of early subclinical hallucinatory experiences associated with delusional ideation, resulting ..
  16. pmc Cognitive behavioural treatment of insomnia in individuals with persistent persecutory delusions: a pilot trial
    Elissa Myers
    King s College London, Institute of Psychiatry, UK
    J Behav Ther Exp Psychiatry 42:330-6. 2011
    ..The clinical implication is that reducing insomnia will reduce paranoid delusions. This study, evaluating for the first time the treatment of insomnia in individuals with persecutory delusions, ..
  17. ncbi Measuring ideas of persecution and social reference: the Green et al. Paranoid Thought Scales (GPTS)
    C E L Green
    Department of Psychology, Institute of Psychiatry, King s College London, UK
    Psychol Med 38:101-11. 2008
    ....
  18. pmc Psychotic-like experiences in major depression and anxiety disorders: a population-based survey in young adults
    Daniel Varghese
    Department of Psychiatry, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia
    Schizophr Bull 37:389-93. 2011
    ..However, it is unclear if these experiences are associated with common mental disorders. The aim of this study was to examine the prevalence of psychotic-like experiences in those with affective and anxiety disorders...
  19. pmc A randomized experimental investigation of reasoning training for people with delusions
    Kerry Ross
    Department of Psychology, Institute of Psychiatry, King s College London, DeCrespigny Park, London, UK
    Schizophr Bull 37:324-33. 2011
    ..a brief reasoning training module changes the "jumping to conclusions" data gathering bias in people with delusions. A secondary aim was to examine whether improvements in reasoning would lead to greater flexibility in thinking ..
  20. pmc Testing the continuum of delusional beliefs: an experimental study using virtual reality
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, London, England
    J Abnorm Psychol 119:83-92. 2010
    ..The second objective was to investigate, drawing upon a cognitive model of persecutory delusions, whether clinical and nonclinical paranoia are associated with similar causal factors...
  21. ncbi Comments on the content of persecutory delusions: does the definition need clarification?
    D Freeman
    Department of Psychology, King s College London, University of London, UK
    Br J Clin Psychol 39:407-14. 2000
    ..In this article, several influential accounts of persecutory delusions are reviewed; differences and difficulties are noted, and their potential effect on cognitive psychological ..
  22. ncbi Improving cognitive treatments for delusions
    Daniel Freeman
    Department of Psychiatry, Oxford University, Warneford Hospital, Oxford, OX3 7JX, UK
    Schizophr Res 132:135-9. 2011
    ..These therapies now lag behind the transformation over the past ten years in understanding the causes of delusions. This paper advocates an interventionist-causal model approach: to focus on one putative causal factor at a time,..
  23. ncbi Dimensional approach to delusions: comparison across types and diagnoses
    P S Appelbaum
    Department of Psychiatry, University of Massachusetts Medical School, Worcester 01655, USA
    Am J Psychiatry 156:1938-43. 1999
    A dimensional approach to the characterization of delusions was used to examine the use of non-content-related descriptors of delusions in revealing differences across diagnostic categories and delusion types.
  24. ncbi Hopping, skipping or jumping to conclusions? Clarifying the role of the JTC bias in delusions
    Cordelia Fine
    Centre for Applied Philosophy and Public Ethics, Department of Philosophy, University of Melbourne, Victoria, Australia
    Cogn Neuropsychiatry 12:46-77. 2007
    There is substantial evidence that patients with delusions exhibit a reasoning bias--known as the "jumping to conclusions" (JTC) bias--which leads them to accept hypotheses as correct on the basis of less evidence than controls...
  25. pmc Neuropsychological functioning and jumping to conclusions in delusions
    Philippa Garety
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK Electronic address
    Schizophr Res 150:570-4. 2013
    It has been consistently demonstrated that delusions are related to jumping to conclusions (JTC), a data-gathering bias and potential candidate endophenotype of psychosis...
  26. pmc The neurobiology of schizotypy: fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people
    P R Corlett
    Connecticut Mental Health Center, Yale University, Department of Psychiatry, Ribicoff Research Facility 34 Park Street, New Haven, CT 06519, USA
    Neuropsychologia 50:3612-20. 2012
    ....
  27. ncbi Self-attacking and self-reassurance in persecutory delusions: a comparison of healthy, depressed and paranoid individuals
    Paul Hutton
    Psychosis Research Unit, Psychology Department, Trust HQ, Greater Manchester West Mental Health Foundation NHS Trust, Bury New Road, Prestwich M25 3BL, United Kingdom
    Psychiatry Res 205:127-36. 2013
    ..To investigate this further, we asked 15 people with persecutory delusions, 15 people with depression and 19 non-psychiatric controls to complete several self-report questionnaires ..
  28. ncbi Explaining transitions over the hypothesized psychosis continuum
    Lydia Krabbendam
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, Maastricht, University, The Netherlands
    Aust N Z J Psychiatry 39:180-6. 2005
    ....
  29. ncbi Metacognitive training in schizophrenia: from basic research to knowledge translation and intervention
    Steffen Moritz
    University Medical Center Hamburg Eppendorf, Department for Psychiatry and Psychotherapy, Hamburg, Germany
    Curr Opin Psychiatry 20:619-25. 2007
    ..We summarize new evidence on cognitive biases thought to trigger or maintain positive symptoms in schizophrenia and present a new therapeutic intervention...
  30. ncbi Emotion and psychosis: links between depression, self-esteem, negative schematic beliefs and delusions and hallucinations
    Ben Smith
    UCL, Department of Mental Health Sciences, Archway Campus, Holborn Union Building, Highgate Hill, London, UK
    Schizophr Res 86:181-8. 2006
    ..A., Kuipers, E.K., Fowler, D., Freeman, D., Bebbington, P.E., 2001. A cognitive model of the positive symptoms of psychosis. Psychological Medicine, 31, 189-195] about the role of emotion and negative evaluative beliefs in psychosis...
  31. ncbi The psychology of persecutory ideation I: a questionnaire survey
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, London, United Kingdom
    J Nerv Ment Dis 193:302-8. 2005
    ..In a recent cognitive model of persecutory delusions, three key factors are highlighted: anomalous experiences, emotion, and reasoning...
  32. ncbi The association between delusional-like experiences and suicidal thoughts and behaviour
    Sukanta Saha
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
    Schizophr Res 132:197-202. 2011
    ..Whilst it is well known that psychotic disorders increase the risk of suicide, it is unclear if DLEs are also associated with suicidal thoughts and behaviour. This study aims to explore these variables in a large population-based sample...
  33. ncbi Jumping to delusions? Paranoia, probabilistic reasoning, and need for closure
    Ryan McKay
    Macquarie Centre for Cognitive Science, Macquarie University, Sydney, Australia
    Cogn Neuropsychiatry 12:362-76. 2007
    ..It was hypothesised that patients with a history of persecutory delusions would display higher need for closure and a more extreme jumping to conclusions bias than healthy control ..
  34. ncbi A pilot study exploring the contribution of working memory to "jumping to conclusions" in people with first episode psychosis
    John Ormrod
    Newcastle University, Newcastle upon Tyne, UK
    Cogn Neuropsychiatry 17:97-114. 2012
    ..The aim of the present study was to explore the contribution of working memory processes (WM) and IQ to hasty decision making and to investigate the stability of this bias over time...
  35. ncbi Can delusions be self-assessed? Concordance between self- and observer-rated delusions in schizophrenia
    Tania Marie Lincoln
    Section for Clinical Psychology and Psychotherapy, Faculty of Psychology, Philipps Universitat Marburg, Gutenbergstr 18, 35032 Marburg, Germany
    Psychiatry Res 178:249-54. 2010
    ..This study tested associations of self- and observer-rated delusions as well as factors associated with discrepancies...
  36. pmc Schizophrenia and monothematic delusions
    Max Coltheart
    Macquarie Centre for Cognitive Science, Macquarie University, Sydney, NSW 2109, Australia
    Schizophr Bull 33:642-7. 2007
    Numerous delusions have been studied which are highly specific and which can present in isolation in people whose beliefs are otherwise entirely unremarkable - "monothematic delusions" such as Capgras or Cotard delusions...
  37. ncbi Explaining delusions: a cognitive perspective
    Vaughan Bell
    Institute of Psychiatry, King s College London, Psychology Department Box 78, De Crespigny Park, London, SE5 8AF, UK
    Trends Cogn Sci 10:219-26. 2006
    ..Although delusions are commonly conceptualized as beliefs, not all models make reference to models of normal belief formation...
  38. ncbi Aberrant connectivity during self-other source monitoring in schizophrenia
    Liang Wang
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada, V6T 2A1
    Schizophr Res 125:136-42. 2011
    ....
  39. ncbi False memory in schizophrenia patients with and without delusions
    Reena Bhatt
    School of Psychology, Cardiff University, Cardiff, UK
    Psychiatry Res 178:260-5. 2010
    b>Delusions are fixed 'false beliefs' and, although a hallmark feature of schizophrenia, no previous study has examined if delusions might be related to 'false memories'...
  40. ncbi The contribution of a cognitive bias against disconfirmatory evidence (BADE) to delusions in schizophrenia
    Todd S Woodward
    University Hospital Hamburg Eppendorf, Germany
    J Clin Exp Neuropsychol 28:605-17. 2006
    ..that provides a measure of a bias against disconfirmatory evidence (BADE), and its correspondence with delusions in people with schizophrenia and schizoaffective disorder was investigated...
  41. pmc From real-world events to psychosis: the emerging neuropharmacology of delusions
    Paul D Morrison
    Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Schizophr Bull 35:668-74. 2009
    ..Here, we discuss how the 3 modulators regulate learning within the striatum and how their dysfunction may lead to delusional thinking...
  42. ncbi The persistence of neuropsychiatric symptoms in dementia: the Cache County Study
    Martin Steinberg
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 19:19-26. 2004
    ..To estimate the 18-month persistence of neuropsychiatric symptoms in dementia in a population-based sample, and to compare the severity of neuropsychiatric symptoms at baseline to the severity at 18-month follow-up...
  43. ncbi Dimensional structure of psychotic symptoms: an item-level analysis of SAPS and SANS symptoms in psychotic disorders
    V Peralta
    Psychiatric Unit, Virgen del Camino Hospital, Pamplona, Spain
    Schizophr Res 38:13-26. 1999
    ..explaining 64% of the total variance: poverty of affect/speech, thought disorder/inappropriate affect, bizarre delusions, social dysfunction, other delusions, paranoid delusions, bizarre behavior, nonauditory hallucinations, auditory ..
  44. pmc The contribution of hypersalience to the "jumping to conclusions" bias associated with delusions in schizophrenia
    William J Speechley
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    J Psychiatry Neurosci 35:7-17. 2010
    Previous schizophrenia research involving the "beads task" has suggested an association between delusions and 2 reasoning biases: (1) "jumping to conclusions" (JTC), whereby early, resolute decisions are formed on the basis of little ..
  45. ncbi Jumping to conclusions in delusional and non-delusional schizophrenic patients
    Steffen Moritz
    Universitatsklinikum Hamburg Eppendorf, Klinik fur Psychiatrie und Psychotherapie, Hamburg, Germany
    Br J Clin Psychol 44:193-207. 2005
    Several studies have provided evidence for the claim that a subgroup of (schizophrenic) patients with current delusions share a jumping to conclusions (JTC) bias...
  46. ncbi 'Jumping to conclusions' and delusions in psychosis: relationship and response to treatment
    Mahesh Menon
    Schizophrenia Program and PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Canada
    Schizophr Res 98:225-31. 2008
    Jumping to conclusions' (JTC) on probabilistic reasoning tasks has been shown to be related with delusions in schizophrenia. However, whether JTC is merely correlated with, moderate or mediate delusions is not known...
  47. ncbi Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusions
    Florian Schlagenhauf
    Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Mitte, Germany
    Biol Psychiatry 65:1032-9. 2009
    Increased attribution of incentive salience to neutral or aversive stimuli might be associated with dysfunction of neuronal processing of positive and negative reinforcement and contribute to the formation of delusions in schizophrenia.
  48. ncbi Association between cannabis use and psychosis-related outcomes using sibling pair analysis in a cohort of young adults
    John McGrath
    Queensland Brain Institute, University of Queensland, St Lucia, Queensland, Australia
    Arch Gen Psychiatry 67:440-7. 2010
    ..The use of sibling pair analysis reduces the influence of unmeasured residual confounding...
  49. ncbi Jumping to conclusions and paranoid ideation in the general population
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, UK
    Schizophr Res 102:254-60. 2008
    An association of a 'jumping to conclusions' (JTC) reasoning style and delusions has been repeatedly found. The data-gathering bias has been particularly implicated with higher levels of delusional conviction in schizophrenia...
  50. ncbi The continuity of psychotic experiences in the general population
    L C Johns
    University of Manchester, UK
    Clin Psychol Rev 21:1125-41. 2001
    ..paper reviews evidence for the continuity of psychotic symptoms with normal experiences, focusing on the symptoms of hallucinations and delusions. It concludes by discussing the theoretical and treatment implications of such a continuum.
  51. ncbi The association between traumatic experience, paranoia and hallucinations: a test of the predictions of psychological models
    A Gracie
    King s College London, Department of Psychology, Institute of Psychiatry, London, UK
    Acta Psychiatr Scand 116:280-9. 2007
    ..The current study investigated the relationship between trauma and predisposition to hallucinations and to paranoia in a non-clinical sample...
  52. ncbi Delusions of alien control in the normal brain
    S J Blakemore
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuropsychologia 41:1058-67. 2003
    b>Delusions of alien control, or passivity experiences, are symptoms associated with schizophrenia in which patients misattribute self-generated actions to an external source...
  53. ncbi Neural correlates of action attribution in schizophrenia
    Chloe Farrer
    Institut des Sciences Cognitives, 67 Boulevard Pinel, 69675 Bron Cedex, France
    Psychiatry Res 131:31-44. 2004
    ..The implications of these results for understanding pathological conditions such as schizophrenia are discussed...
  54. ncbi Midbrain activation during Pavlovian conditioning and delusional symptoms in schizophrenia
    Liana Romaniuk
    University of Edinburgh, Royal Edinburgh Hospital, Scotland
    Arch Gen Psychiatry 67:1246-54. 2010
    Recent theories have suggested that the inappropriate activation of limbic motivational systems in response to neutral stimuli may underlie the development of delusions in schizophrenia.
  55. ncbi The relevance of self-esteem and self-schemas to persecutory delusions: a systematic review
    Marie Luise Kesting
    Section for Clinical Psychology and Psychotherapy, Department of Psychology, Philipps Universitat Marburg, Gutenbergstraße 18, 35032 Marburg, Germany Electronic address
    Compr Psychiatry 54:766-89. 2013
    Self-esteem is frequently targeted in psychological approaches to persecutory delusions (PD)...
  56. pmc A randomised controlled trial of a worry intervention for individuals with persistent persecutory delusions
    Chloe Foster
    Department of Psychology, Institute of Psychiatry, King s College London, Denmark Hill, UK
    J Behav Ther Exp Psychiatry 41:45-51. 2010
    ..Therefore, the aim was to target worry in a therapeutic intervention for individuals with delusions. It was predicted that a worry intervention would reduce levels of worry and paranoia distress...
  57. ncbi The relationship between delusions and violence: findings from the East London first episode psychosis study
    Jeremy W Coid
    Queen Mary University of London, Forensic Psychiatry Research Unit, Barts and the London School of Medicine and Dentistry, Wolfson Institute of Preventive Medicine, England
    JAMA Psychiatry 70:465-71. 2013
    Psychotic persons who are violent often explain their violence as being due to delusions. However, research has failed to confirm associations between delusions and violent behavior.
  58. ncbi Effect of culture and environment on the phenomenology of delusions and hallucinations
    Kausar Suhail
    Dept of Psychology, Govt College Lahore, Pakistan
    Int J Soc Psychiatry 48:126-38. 2002
    ..study was conducted to compare the influence of culture and immediate environment on the phenomenology of schizophrenic symptoms by examining the actual content of delusions and hallucinations in three groups of schizophrenic patients.
  59. ncbi The psychology of persecutory ideation II: a virtual reality experimental study
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, London, United Kingdom
    J Nerv Ment Dis 193:309-15. 2005
    A cognitive model of persecutory delusions is used to predict the occurrence of nonclinical paranoid thoughts in a virtual reality environment...
  60. ncbi Religious delusions in patients admitted to hospital with schizophrenia
    Ronald Siddle
    Department of Clinical Psychology, North Manchester General Hospital, Crumpsall, UK
    Soc Psychiatry Psychiatr Epidemiol 37:130-8. 2002
    Religious delusions are clinically important because they may be associated with selfharm and poorer outcomes from treatment. They have not been extensively researched...
  61. ncbi Striatal lesions in delusional parasitosis revealed by magnetic resonance imaging
    Markus Huber
    Department of Psychiatry, General Hospital Bruneck, Spitalstrasse 4, 39031 Bruneck, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 32:1967-71. 2008
    ..Systematic brain imaging studies are lacking. We aimed to identify a brain region with structural lesions in patients with DP in order to better understand the pathophysiology of DP...
  62. ncbi Old wine in new bottles? Stability and plasticity of the contents of schizophrenic delusions
    T Stompe
    University Hospital for Psychiatry Vienna, Vienna, Austria
    Psychopathology 36:6-12. 2003
    ..the last 20 years described a quick inclusion of new technologies and cultural innovations into schizophrenic delusions which led many of the authors to the conclusion that the 'Zeitgeist' is creating new delusional contents...
  63. ncbi Delusions and decision-making style: use of the Need for Closure Scale
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, University of London, PO Box 77, Denmark Hill, London, SE5 8AF, UK
    Behav Res Ther 44:1147-58. 2006
    ..The aim of the study is to determine whether NFC has such a direct link with delusions. A secondary aim is to examine if NFC is related to the delusion-associated reasoning process of 'jumping to ..
  64. ncbi Cognitive factors maintaining persecutory delusions in psychosis: the contribution of depression
    Natasha Vorontsova
    Department of Psychology, Institute of Psychiatry, King s College London
    J Abnorm Psychol 122:1121-31. 2013
    ..study was to test whether depression and associated cognitive processes predict the maintenance of persecutory delusions. Three groups of participants were tested at baseline: 60 patients with persecutory delusions in the context of ..
  65. ncbi Delusions of Korean patients with Alzheimer's disease: study of drug-naïve patients
    Yong Tae Kwak
    Department of Neurology, Hyoja Geriatric Hospital, Gyeonggi, Korea
    Geriatr Gerontol Int 13:307-13. 2013
    Although delusions are one of the most prominent psychiatric symptoms in Alzheimer's disease (AD), research on the subtypes, prevalence and associated factors of delusions, especially in drug (psychotropic)-naïve patients, has been ..
  66. ncbi Why do people with delusions fail to choose more realistic explanations for their experiences? An empirical investigation
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, University of London, London, United Kingdom
    J Consult Clin Psychol 72:671-80. 2004
    b>Delusions can be viewed as explanations of experiences,. By definition, the experiences are insufficient to merit the delusional explanations...
  67. pmc Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
    P R Corlett
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Brain 130:2387-400. 2007
    b>Delusions are maladaptive beliefs about the world...
  68. pmc Differences in cognitive and emotional processes between persecutory and grandiose delusions
    Philippa A Garety
    Department of Psychology, Institute of Psychiatry, King s College London, PO77, Henry Wellcome Building, De Crespigny Park, London SE5 8AF, UK
    Schizophr Bull 39:629-39. 2013
    ..propose that cognitive and emotional processes, in the context of anomalies of experience, lead to and maintain delusions. No large-scale studies have investigated whether persecutory and grandiose delusions reflect differing ..
  69. ncbi Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    J Affect Disord 125:341-4. 2010
    ..Previous studies in bipolar patients reported non-significant trends in the same direction...
  70. ncbi The neuropsychology of delusions
    Max Coltheart
    Macquarie Centre for Cognitive Science, Macquarie University, Sydney, NSW, Australia
    Ann N Y Acad Sci 1191:16-26. 2010
    ..studies in this context suggest that the region of the brain specifically involved in hypothesis evaluation (and therefore, according to the two-factor theory, impaired in people with delusions) is the right lateral prefrontal cortex.
  71. ncbi Relationship between delusions and regional cerebral blood flow in Alzheimer's disease
    Seigo Nakano
    Department of Internal Medicine, Fukuoka University, Fukuoka, Japan
    Dement Geriatr Cogn Disord 21:16-21. 2006
    To investigate the association between delusions and cerebral functional deficits in Alzheimer's disease (AD), we evaluated probable AD patients with and without delusions.
  72. ncbi What happened to the voices? A fine-grained analysis of how hallucinations and delusions change under psychiatric treatment
    Sophia D Schneider
    University Medical Center Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martinistr 52, Hamburg, Germany
    Psychiatry Res 188:13-7. 2011
    ..Rating Scales (PSYRATS) have demonstrated their usefulness for the dimensional assessment of hallucinations and delusions. However, there is no evaluated German version of the PSYRATS to date...
  73. ncbi Change in delusions is associated with change in "jumping to conclusions"
    Todd S Woodward
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychiatry Res 170:124-7. 2009
    ..that premature termination of data collection and jumping to conclusions behavior (JTC) is associated with delusions. However, few investigations have attempted to track associations between changes in delusions and changes in ..
  74. pmc Deficits in sensory prediction are related to delusional ideation in healthy individuals
    Christoph Teufel
    Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuropsychologia 48:4169-72. 2010
    ..processes in schizophrenic patients and these low-level deficits are thought to contribute to the emergence of delusions of control...
  75. ncbi A cognitive bias against disconfirmatory evidence (BADE) is associated with schizotypy
    Lisa Buchy
    Department of Research, Riverview Hospital, Coquitlam, B C, Canada V3C 4J2
    Schizophr Res 90:334-7. 2007
    ..This result provides support for the "schizophrenia spectrum" account of psychosis...
  76. ncbi Attentional modulation of external speech attribution in patients with hallucinations and delusions
    Lana Marija Ilankovic
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychologia 49:805-12. 2011
    A range of psychological theories have been proposed to account for the experience of auditory hallucinations and delusions in schizophrenic patients...
  77. ncbi Misattribution of external speech in patients with hallucinations and delusions
    Paul P Allen
    Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, P O BOX 67, Denmark Hill, London SE5 8AF, UK
    Schizophr Res 69:277-87. 2004
    ..We examined whether patients with hallucinations and delusions would demonstrate an externalising bias on a task that did not involve cognitive self-monitoring.
  78. ncbi Cognitive and emotional predictors of predisposition to hallucinations in non-patients
    Anthony P Morrison
    Psychology Services, Mental Health Services of Salford, UK
    Br J Clin Psychol 41:259-70. 2002
    ..We aimed to test the specific hypothesis that positive interpretations of voices would predict frequency of hallucinatory experiences...
  79. ncbi Why we need more debate on whether psychotic symptoms lie on a continuum with normality
    A S David
    Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King s College, London, UK
    Psychol Med 40:1935-42. 2010
    ..Finding the distinctive characteristics of psychotic phenomena in people with clinical disorders, in addition to their origins in 'normal' cognitive processes, is a worthwhile goal...
  80. pmc Persecutory ideation and insomnia: findings from the second British National Survey of Psychiatric Morbidity
    Daniel Freeman
    King s College London, Department of Psychology, PO Box 077, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK
    J Psychiatr Res 44:1021-6. 2010
    ..The results are consistent with recent developments in the cognitive understanding of persecutory delusions, in which insomnia, negative affect, and substance use are identified as key factors...
  81. ncbi Alteration of rCBF in Alzheimer's disease patients with delusions of theft
    R Fukuhara
    Department of Neuropsychiatry, Ehime University School of Medicine, Shigenobu-chou, Onsen-gun, Ehime 791-0295, Japan
    Neuroreport 12:2473-6. 2001
    ..Nine AD patients with only one type of delusion (delusions of theft) and nine age, cognitive function-matched AD patients without any type of delusions were selected from ..
  82. ncbi Neuroimaging of delusions in Alzheimer's disease
    Zahinoor Ismail
    Centre for Addiction and Mental Health, Geriatric Mental Health Program, Toronto, Ontario, Canada
    Psychiatry Res 202:89-95. 2012
    ..searched using the keywords "imaging", "neuroimaging", "CT", "MRI", "PET", "SPECT", "Alzheimer's", "dementia", "delusions" and "psychosis" to find studies specifically assessing or reporting on neuroimaging of delusions in Alzheimer's ..
  83. ncbi Perceptions of hostility by persons with and without persecutory delusions
    Dennis R Combs
    Department of Psychology, University of Texas at Tyler, Tyler, TX 75799, USA
    Cogn Neuropsychiatry 14:30-52. 2009
    ..cues regarding the intentions of others are lacking, may be perceived as hostile by persons with persecutory delusions (PD). Thus, a social-cognitive bias for the perception of hostility may be present...
  84. ncbi Abductive inference and delusional belief
    Max Coltheart
    Centre for Cognitive Science, Macquarie University, Sydney, NSW 2019, Australia
    Cogn Neuropsychiatry 15:261-87. 2010
    ..Second, we argue that in relation to many delusions (we consider seven) one can clearly identify what the abnormal cognitive data are which prompted the delusion ..
  85. ncbi Delusions of Japanese patients with Alzheimer's disease
    Manabu Ikeda
    Department of Neuropsychiatry, Ehime University School of Medicine, Ehime, Japan
    Int J Geriatr Psychiatry 18:527-32. 2003
    b>Delusions constitute one of the most prominent psychiatric complications in Alzheimer's disease (AD). However, there is little consensus of the prevalence and associated factors for delusions in AD.
  86. pmc Are screening instruments valid for psychotic-like experiences? A validation study of screening questions for psychotic-like experiences using in-depth clinical interview
    Ian Kelleher
    Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Schizophr Bull 37:362-9. 2011
    ..Our results suggest that it may be possible to screen the general adolescent population for psychotic-like experiences with a high degree of accuracy using a short self-report questionnaire...
  87. ncbi The Psychotic Symptom Rating Scales (PSYRATS): their usefulness and properties in first episode psychosis
    Richard Drake
    Division of Psychiatry, University of Manchester, 2nd Floor Education and Research Centre, Wythenshawe Hospital, Manchester, M23 9PL, United Kingdom
    Schizophr Res 89:119-22. 2007
    ..The PSYRATS have been shown to assess dimensions of hallucination and delusions reliably and validly in chronically psychotic patients but not in first episode patients...
  88. ncbi Are theory of mind deficits in understanding intentions of others associated with persecutory delusions?
    Stephanie Mehl
    Department of Psychiatry, Rheinische Friedrich Wilhelms University, Bonn, Germany
    J Nerv Ment Dis 198:516-9. 2010
    ..of this study was to investigate the association of the Theory of Mind ability to infer intentions of others and delusions in patients with schizophrenia-spectrum disorders...
  89. ncbi Belief inflexibility in schizophrenia
    Todd S Woodward
    Department of Psychiatry, University of British Columbia, and BC Mental Health and Addictions Research Institute, PHSA Research and Networks, Vancouver, BC, Canada
    Cogn Neuropsychiatry 13:267-77. 2008
    ..using delusion-neutral material have demonstrated that patients with schizophrenia, particularly those with delusions, display a bias against disconfirmatory evidence (BADE)...
  90. pmc Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease
    Suzanne Reeves
    Section of Old Age Psychiatry, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, De Crespigny Park, Camberwell, London SE5 8AF, UK
    Neurology 72:528-34. 2009
    ..This study aimed to test the hypothesis that the symptom domains delusions and apathy would be associated with striatal dopamine (D2) receptor function in AD.
  91. ncbi Relationship between hallucinations, delusions, and rapid eye movement sleep behavior disorder in Parkinson's disease
    Claudio Pacchetti
    Parkinson s Disease and Movement Disorders Unit, IRCCS C Mondino Institute of Neurology, Pavia, Italy
    Mov Disord 20:1439-48. 2005
    ..of the subjects presented with psychotic disorders; 30% (n = 86) had experienced hallucinations; 2% (n = 6) had delusions without hallucinations. Sixty-two (72%) hallucinators reported nocturnal hallucinations. A total of 6...
  92. ncbi ApoE epsilon4 allele is associated with incidental hallucinations and delusions in patients with AD
    J B Chang
    Department of Neurology, National Yang Ming University School of Medicine, Taipei County, Taiwan
    Neurology 63:1105-7. 2004
    ..The presence of the ApoE epsilon4 allele carried a 19.0-fold risk for developing hallucinations and a 3.4-fold risk for delusions.
  93. ncbi Demographic correlates of psychotic-like experiences in young Australian adults
    J Scott
    Child and Youth Mental Health Service, Royal Children s Hospital, Herston, Australia
    Acta Psychiatr Scand 118:230-7. 2008
    ..Psychotic-like experiences (PLE) in the general community are common. The aims of this study were to examine the prevalence and demographic correlates of PLE in young adults...
  94. pmc Delusions in frontotemporal lobar degeneration
    Rohani Omar
    Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Neurol 256:600-7. 2009
    We assessed the significance and nature of delusions in frontotemporal lobar degeneration (FTLD), an important cause of young-onset dementia with prominent neuropsychiatric features that remain incompletely characterised...
  95. ncbi Delusions and processing of discrepant information: an event-related brain potential study
    J Bruno Debruille
    Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Schizophr Res 89:261-77. 2007
    One possible explanation for why delusions persist despite the awareness of contradictory information is that the new information fails to be integrated...
  96. pmc Delusions and hallucinations are associated with worse outcome in Alzheimer disease
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, New York, NY 10032, USA
    Arch Neurol 62:1601-8. 2005
    b>Delusions and hallucinations are common in Alzheimer disease (AD) and there are conflicting reports regarding their ability to predict cognitive decline, functional decline, and institutionalization...
  97. ncbi Delusional infestation, including delusions of parasitosis: results of histologic examination of skin biopsy and patient-provided skin specimens
    Sara A Hylwa
    Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Dermatol 147:1041-5. 2011
    To review the results of skin biopsies and patient-provided specimens from patients whose assessment was consistent with delusional infestation, including delusions of parasitosis.
  98. ncbi Measuring delusional ideation: the 21-item Peters et al. Delusions Inventory (PDI)
    Emmanuelle Peters
    Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Schizophr Bull 30:1005-22. 2004
    ..Norms are reported for a new 21-item version of the Peters et al. Delusions Inventory (PDI; Peters et al. 1999b)...
  99. ncbi The self in action: lessons from delusions of control
    Chris Frith
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, UK
    Conscious Cogn 14:752-70. 2005
    Patients with delusions of control are abnormally aware of the sensory consequences of their actions and have difficulty with on-line corrections of movement. As a result they do not feel in control of their movements...
  100. ncbi A generalized bias against disconfirmatory evidence in schizophrenia
    Steffen Moritz
    University of Hamburg, University Hospital of Psychiatry, Germany
    Psychiatry Res 142:157-65. 2006
    Fixation onto false/unrealistic beliefs is a core feature of schizophrenic delusions. A recent study conducted by our research group has provided evidence for the presence of a bias against disconfirmatory evidence (BADE) in patients ..
  101. ncbi Do antipsychotics improve reasoning biases? A review
    Suzanne H So
    Department of Psychology, Institute of Psychiatry, King s College London, London, United Kingdom
    Psychosom Med 72:681-93. 2010
    ..Patients with schizophrenia, especially those with delusions, show not only cognitive deficits but also "reasoning biases," namely, "jumping to conclusions," reduced belief ..

Research Grants63

  1. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..Current treatment, while generally effective for reducing positive psychotic symptoms(delusions, hallucinations, thought disorder) frequently leads to a number of untoward side-effects...
  2. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2012
    ..seen in AD, many patients exhibit a range of non-cognitive symptoms that include depression, aggression, delusions and hallucinations...
  3. Serotonergic modulation of claustro-cortical circuits
    Jay A Gingrich; Fiscal Year: 2013
    ..in these brain functions offers possible insight into the symptoms of disorganization, hallucinations, delusions, lack of relatedness, involution, distractedness, and cognitive decline that characterize these disorders...
  4. Structural and Functional Alterations of Interneurons in Models of Schizophrenia
    Istvan Mody; Fiscal Year: 2012
    ..treatments for schizophrenia are most effective in treating positive symptoms, comprising hallucinations and/or delusions. However, such antipsychotics yield little amelioration of the burden of negative symptoms and cognitive ..
  5. In vitro tools for preclinical analysis of cognitive therapies for schizophrenia
    KRISTEN RICHARDSON; Fiscal Year: 2012
    ..Symptoms of schizophrenia are classified into three categories: positive (delusions and hallucinations), negative (flattened affect, social isolation) and cognitive (impaired attention, executive ..
  6. Mechanism-based, pro-cognitive therapies for schizophrenia
    DAVID JULIAN GERBER; Fiscal Year: 2010
    ..Symptoms of schizophrenia can be grouped into three categories: positive symptoms, including hallucinations and delusions;negative symptoms, such as social isolation and flattened affect;and cognitive symptoms, which include impaired ..
  7. Influence of Psychosis on Brain-Behavior Endophenotypes for Bipolar Disorder
    David C Glahn; Fiscal Year: 2012
    ..and neuroimaging endophenotypes for the disorder must account for the potential impact of hallucinations and delusions on these markers...
  8. First-Episode Psychosis and Pre-Onset Cannabis Use
    Michael T Compton; Fiscal Year: 2012
    ..e., hallucinations and delusions), and the nature of negative, cognitive, neurological, and positive symptoms of schizophrenia...
  9. GABAergic and Reelin Deficits in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2013
    ..e., apathy, poor or nonexistent social functioning) and positive (presence of hallucinations, delusions) symptoms, and a lifetime prevalence of 1%...
  10. Plasticity-Based Adaptive Cognitive Remediation for Schizophrenia
    HENRY WILTSHIRE MAHNCKE; Fiscal Year: 2010
    ..challenges in functional abilities were caused by the overt symptoms of schizophrenia, like hallucinations and delusions;however research has now shown that these challenges are largely a result of problems with cognitive abilities, ..
  11. Towards understanding cellular mechanisms of positive symptoms of schizophrenia
    Stanislav S Zakharenko; Fiscal Year: 2013
    ..the world's population and is characterized by a constellation of symptoms that include hallucinations and delusions (positive symptoms), antisocial behavior and blunted emotions (negative symptoms), deficits in working memory, ..
  12. Engrafting human neurons into animal models to study schizophrenia
    Krishnan Padmanabhan; Fiscal Year: 2013
    ..is a debilitating psychiatric disorder characterized by an array of symptoms including hallucinations, delusions, difficulty expressing emotions, and deficits in attention and memory...
  13. Microstructural Characterization of White Matter in Schizophrenia
    Mariana Lazar; Fiscal Year: 2010
    Schizophrenia is a chronic, severe, and disabling disorder that is characterized by hallucinations, delusions, and motor deficits...
  14. Using fMRI to Measure Negative Symptoms in Schizophrenia
    EDWARD E contact SMITH; Fiscal Year: 2010
    ..Schizophrenia, a devastating psychiatric disorder, is chiefly characterized by positive symptoms, such as delusions and hallucinations, and negative symptoms, such as anhedonia (lack of pleasure), avolition (lack of willed-..
  15. Identifying the clinicopathologic basis of dementia-related psychosis
    Katherine P Rankin; Fiscal Year: 2013
    ..datasets to identify the clinical phenomenology, neuroanatomy, and neuropathology underlying different types of delusions and hallucinations in three diseases of aging: Alzheimer's disease (AD), behavioral variant frontotemporal ..
  16. Schizophrenia Pharmacogenetics: cognition and symptom response to antipsychotics
    Jeffrey R Bishop; Fiscal Year: 2013
    ..Psychotic symptoms like hallucinations and delusions that occur with this disease often respond well to antipsychotic agents like risperidone...
  17. Control of Attention by Working Memory
    Steven J Luck; Fiscal Year: 2013
    ..Although hallucinations and delusions are the most salient symptoms of this disease, schizophrenia also involves pervasive cognitive deficits that are ..
  18. Optimization of Novel NR2C and NR2D subunit-selective NMDA receptor potentiators
    KAMALESH RUPPA; Fiscal Year: 2013
    ..Current therapies to treat this disorder have been effective in ameliorating positive symptoms (hallucinations, delusions, irrational fear), but are less effective in controlling negative symptoms (social withdrawal, anhedonia) and ..
  19. Dextras1, Brain Iron Homeostasis and Mental Health
    Sangwon F Kim; Fiscal Year: 2010
    Schizophrenia is commonly recognized by its psychotic symptoms such as delusions and hallucinations, which often leads to social and functional impairment...
  20. Prediction of Psychosis in Alzheimer Disease
    Robert A Sweet; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer Disease (AD+Psychosis, AD+P), affecting ~ 40% to 60% of individuals with AD...
  21. The Neural Basis of Delusions in Schizophrenia: Studies of Emotional Perception
    Daphne J Holt; Fiscal Year: 2010
    ..application for an NIMH Patient-Oriented Research Career Development Award (K-23) entitled "The Neural Basis of Delusions in Schizophrenia: Studies of Emotional Perception...
  22. Novel serotonergic, pro-cognitive antipsychotic therapies
    Silvana Leit; Fiscal Year: 2012
    ..The symptoms of schizophrenia can be grouped into three major categories: positive (e.g. hallucinations and delusions), negative (e.g. social isolation and inappropriate emotional response), and cognitive symptoms...
  23. Evaluation of Mouse Hallucinations by fMRI
    Paul H Patterson; Fiscal Year: 2012
    ..gating, it is said to be impossible to evaluate the positive symptoms of schizophrenia, hallucinations and delusions. Thus, this disorder is often considered to be "uniquely human"...
  24. Dcycloserine Augmentation of Cognitive Behavioral Therapy for Delusions
    Donald C Goff; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Antipsychotic-resistant delusions are common in schizophrenia and are frequently responsible for incarceration and self injury...
  25. Corollary Discharge Dysfunction in Schizophrenia: ERPs and EEG
    Judith M Ford; Fiscal Year: 2012
    ..It may also contribute to symptoms such as hallucinations, delusions, and even the desire to engage with people and in activities...
  26. Clinical and Computational Studies of Dopamine Function in Schizophrenia
    James M Gold; Fiscal Year: 2013
    ..deficits and negative symptoms than it is with the positive symptoms of the illness including hallucinations and delusions. Negative symptoms are generally defined as the absence of normal function, but the actual mechanisms involved ..
  27. Quantitative Behavioral and Imaging Phenotypes of Amotivation in Schizophrenia
    Daniel H Wolf; Fiscal Year: 2013
    ..Unlike positive symptoms (hallucinations, delusions) which are generally responsive to antipsychotic medications, negative symptoms including amotivation respond ..
  28. Anxiolytic Property of Atypical Antipsychotics
    Ming Li; Fiscal Year: 2009
    ..Although both groups show similar efficacy against psychosis (e.g., delusions, hallucinations), it is unclear whether atypicals as a class have intrinsic and superior benefits over typicals ..
  29. Molecular biology of mesocortical and mesoaccumbens dopamine neurons
    JEFFREY EELLS; Fiscal Year: 2009
    ..dopamine neurotransmission contributing to positive symptoms of schizophrenia (paranoia, hallucinations, delusions, and bizarre behavior) and attenuated mesocortical dopamine neurotransmission affecting negative symptoms (..
  30. Cognitive Control and Language Impairments in Schizophrenia
    Tamara Y Swaab; Fiscal Year: 2013
    ..Although hallucinations and delusions are the most salient symptoms of this disease, language abnormalities are among the most prominent cognitive ..
  31. Subtype Specific Agonists for D1-D5 Dopamine Receptors
    William Goddard; Fiscal Year: 2007
    ..Dopamine receptor antagonists have been developed to block hallucinations and delusions that occur in schizophrenic patients, whereas dopamine receptor agonists are effective in alleviating the ..
  32. Antipsychotic Treatment Effects on Attention &Working Memory in Schizophrenia
    James L Reilly; Fiscal Year: 2013
    ..in antipsychotic pharmacotherapy have resulted in important gains for treating symptoms of hallucinations and delusions, cognitive deficits have been far less responsive to standard treatments...
  33. SIGMA LIGAND ELECTROPHYSIOLOGY IN RAT HIPPOCAMPAL SLICE
    Christine Eccles; Fiscal Year: 1991
    ..At appropriate doses, however, they can cause psychotomimetic effects such as delusions, hallucination, depersonalization and dysphoria which are not blocked by the mu/kappa opiate antagonist naloxone...
  34. Longitudinal Imaging of Patients at Clinical Risk for Psychosis.
    Scott A Small; Fiscal Year: 2013
    ..with schizophrenia itself, related to the severity of positive psychotic symptoms across illness stages such as delusions, and predicted progression to psychosis from a prodromal or clinical high-risk state in a small cohort (Schobel, ..
  35. PARTIAL DOPAMINEAGONIST TREATMENT OF SCHIZOPHRENIA
    Carol Tamminga; Fiscal Year: 2002
    ..of these three aims will be evaluated in the three primary symptom cluster of schizophrenia: 1) hallucinations/delusions; 2) disorganization, and 3) negative symptoms, and on cognitive function...
  36. EPILEPSY AS A NEUROLOGICAL MODEL OF SCHIZOPHRENIA
    Laura Marsh; Fiscal Year: 2000
    ..be tested: Hypothesis 1: ESZ and ISZ will demonstrate similar profiles of positive symptoms (hallucinations, delusions, and thought disorder) and negative symptoms (e.g...
  37. DNA EXPANSION IN SCHIZOPHRENIA
    Cynthia McMurray; Fiscal Year: 2000
    ..from applicant's abstract): Schizophrenia is a severe disorder characterized by psychotic symptoms such as delusions and hallucinations and/or debilitating behavioral symptoms...
  38. Understanding Delusions: Aberrant Salience and Defensive Self-Processing
    DAVID COLIN CICERO; Fiscal Year: 2010
    ..g., low self-concept clarity) may be related to delusions in schizophrenia. However, the mechanisms that underlie anomalous experiences have been largely unexplored...
  39. SCHIZOPHRENIC COGNITION: A LONGITUDINAL STUDY
    Martin Harrow; Fiscal Year: 1992
    ..phase, during partial recovery, and are being followed up at various phases during the posthospital period, for delusions, hallucinations, disordered thinking, and negative symptoms...
  40. Cognitive Treatments of Hallucinations in Schizophrenia
    Sandra Wilkniss; Fiscal Year: 2005
    ..are not responsive to antipsychotic medication and continue to suffer from distressing positive symptoms such as delusions and hallucinations...
  41. A thyroid receptor co-activator hypothesis for psychosis
    Robert Philibert; Fiscal Year: 2005
    ..S. population and is characterized by the presence of hallucinations and delusions. Genetic factors are thought to account for the majority of the vulnerability to illness for this syndrome...
  42. DEVICE AND METHOD FOR BIOMARKERS IN SCHIZOPHRENIA
    George Hu; Fiscal Year: 2009
    ..a biomarker for schizophrenia, which is a severe, heterogeneous mental disorder that leads to hallucinations and delusions, social withdrawal, and cognitive decline...
  43. Ampakines in Schizophrenia
    Steven Johnson; Fiscal Year: 2002
    ..Applicant's Abstract) Currently available antipsychotics effectively control positive symptoms (hallucinations, delusions), but persistent negative symptoms (withdrawal, apathy) and cognitive deficits are little affected and can be ..
  44. Computerized Interactive Assessment of Functional Skills for Schizophrenia Drug T
    KOLLEEN HURLEY; Fiscal Year: 2009
    ..2000). Unfortunately, while current antipsychotic treatments control the delusions and hallucinations found in people with schizophrenia, these drugs are unable to provide more than minimal ..
  45. Neural Patterns of Visual Learning in Schizophrenia
    Nicola Cascella; Fiscal Year: 2006
    ..multiple symptom manifestations that cluster into at three domains: (1) reality distortion (hallucinations and delusions), (2) negative symptoms (psychomotor retardation), and (3) disorganization (thought disorder)...
  46. SCHIZOPHRENIC COGNITION--A LONGITUDINAL STUDY
    Martin Harrow; Fiscal Year: 2001
    ..phase, during partial recovery, and are being followed up at various phases during the posthospital period, for delusions, hallucinations, disordered thinking, and negative symptoms...
  47. DELUSIONS AND CEREBRAL METABOLISM IN ALZHEIMERS DISEASE
    David Sultzer; Fiscal Year: 2001
    ..b>Delusions are common in patients with AD and contribute substantially to behavioral disturbances and other morbid aspects ..
  48. fMRI Localization of Psychotic Symptoms in Schizophrenia
    David Silbersweig; Fiscal Year: 2005
    ..Psychosis, consisting of the symptoms of delusions and- hallucinations, represents the most striking and severe part of the psychiatric symptom spectrum, and ..
  49. Neural Correlates of Source Monitoring in Schizophrenia
    Anthony Weiss; Fiscal Year: 2007
    ..eventual goal of examining the role of these faulty cognitive processes in the production of hallucinations and delusions. In addition to the proposed research described below, the candidate seeks training in functional neuroimaging ..
  50. EFFECTS OF AGING ON MEMORY FOR SOURCE OF INFORMATION
    Marcia Johnson; Fiscal Year: 2003
    ..where, to potential increased vulnerability to false memories in eyewitness situations or to the development of delusions. The proposed research focuses on the retrieval and evaluation phase of episodic remembering (source monitoring)...
  51. GERIATRIC MAJOR DEPRESSION AND DELUSIONS
    Barnett Meyers; Fiscal Year: 1991
    ..unipolar major depressives will be separated into three clinical groups based upon presence and type of delusions: mood-congruent delusional depressives; mood- incongruent delusional depressives; and depressives without ..
  52. Neuroanatomy of Emotion in Treatment Resistant Psychosis
    Stephan Taylor; Fiscal Year: 2006
    ..We hypothesize that positive symptoms of psychosis involve the inappropriate attribution of salience, such as delusions of reference, while negative symptoms involve a failure to respond to emotional stimuli...
  53. TREATMENT AND OUTCOME OF EARLY ONSET BIPOLAR DISORDER
    Vivian Kafantaris; Fiscal Year: 2005
    ..In adolescents, bipolar disorder is often accompanied by delusions, hallucinations, or severe assaultive or destructive behaviors that require acute treatment with adjunctive ..
  54. NEUROPSYCHOLOGY OF PSYCHOSIS IN ALZHEIMERS DISEASE
    Jane Paulsen; Fiscal Year: 2000
    ..Until research finds a means of treating AD with curative measures, symptoms such as delusions and hallucinations must be aggressively identified, diagnosed, and managed...
  55. Cannabinoids and cortical-cerebellar function
    Sachin Patel; Fiscal Year: 2005
    Cannabis intoxication is known to produce psychotic symptoms such as delusions, and disorganized thoughts resembling schizophrenia...
  56. LANGUAGE DISTURBANCE IN SCHIZOPHRENIA
    William Sledge; Fiscal Year: 1991
    ..impatient and one outpatient; two groups of affective disorder (major depression with mood congruent delusions) patients - one inpatient and one outpatient; and a group of non-psychiatric volunteers...
  57. Semantic processing in schizophrenia: Symptoms & memory
    JOSCELYN FISHER; Fiscal Year: 2005
    Positive symptoms, such as delusions and thought disorder, are some of the most puzzling aspects of schizophrenia...
  58. Emotional Awareness and Peculiar Beliefs
    MATTHEW BODEN; Fiscal Year: 2006
    ..emotions/emotional processes, interact with which (b) cognitive biases (previously found to be associated with delusions), and with which (c) individual differences (e.g...
  59. Epigenetic Variation and its Determinants in Depression
    James Potash; Fiscal Year: 2008
    ..Results from the novel studies proposed in this application should shed light on the epigenetic mechanisms and gene-environment interactions that result in vulnerability to depression. ..
  60. Genetic Linkage and Association in Bipolar Disorder
    James Potash; Fiscal Year: 2009
    ..These new variants would then be tested for association in our sample. The important findings that have already emerged from our very carefully assessed sample argue for the benefits of extending this valuable resource. ..
  61. Neural Network Models of Language
    Ralph Hoffman; Fiscal Year: 2005
    ..such as derailment and illogicality), (II) negative thought disorder (reduced language outputs), and (III) delusions of the idee fixe type...
  62. rTMS Clinical Trial for Auditory Hallucinations
    RALPH EDWARD HOFFMAN; Fiscal Year: 2010
    ..This study will provide critical information regarding positioning strategies that optimize rTMS for AHs, as well as new insights regarding underlying pathophysiology. ..
  63. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Constantine Lyketsos; Fiscal Year: 2007
    ..unreadable] [unreadable]..