aggression

Summary

Summary: A form of behavior which leads to self-assertion; it may arise from innate drives and/or a response to frustration; may be manifested by destructive and attacking behavior, by covert attitudes of hostility and obstructionism, or by healthy self-expressive drive to mastery. (Dorland 27th ed)

Top Publications

  1. ncbi Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
  2. pmc Targeted manipulation of serotonergic neurotransmission affects the escalation of aggression in adult male Drosophila melanogaster
    Olga V Alekseyenko
    Neurobiology Department, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 5:e10806. 2010
  3. ncbi Girls' hyperactivity and physical aggression during childhood and adjustment problems in early adulthood: a 15-year longitudinal study
    Nathalie Fontaine
    Department of Psychology, University College London, London, England
    Arch Gen Psychiatry 65:320-8. 2008
  4. pmc Identification of an aggression-promoting pheromone and its receptor neurons in Drosophila
    Liming Wang
    Division of Biology 216 76, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 463:227-31. 2010
  5. ncbi Identification of protein pheromones that promote aggressive behaviour
    Pablo Chamero
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92030, USA
    Nature 450:899-902. 2007
  6. ncbi Dysfunction in the neural circuitry of emotion regulation--a possible prelude to violence
    R J Davidson
    Laboratory for Affective Neuroscience and W M Keck Laboratory for Functional Brain Imaging and Behavior, University of Wisconsin Madison, Madison, WI 53706, USA
    Science 289:591-4. 2000
  7. pmc Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression
    C Marquez
    Laboratory of Behavioral Genetics, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Transl Psychiatry 3:e216. 2013
  8. ncbi Modulation of Fgfr1a signaling in zebrafish reveals a genetic basis for the aggression-boldness syndrome
    William H J Norton
    Zebrafish Neurogenetics, Laboratory of Neurobiology and Development, Institut de Neurobiologie Alfred Fessard, Unité Propre de Recherche 3294, CNRS, Avenue de la Terrasse, Gif sur Yvette, 91190, France
    J Neurosci 31:13796-807. 2011
  9. pmc Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression
    Dongsha Wang
    Sainte Justine Hospital Research Center, Montreal, Quebec, Canada
    PLoS ONE 7:e39501. 2012
  10. ncbi Violent video game effects on aggression, empathy, and prosocial behavior in eastern and western countries: a meta-analytic review
    Craig A Anderson
    Department of Psychology, W112 Lagomarcino Hall, Iowa State University, Ames, IA 50011, USA
    Psychol Bull 136:151-73. 2010

Detail Information

Publications350 found, 100 shown here

  1. ncbi Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
    Mice experiencing repeated aggression develop a long-lasting aversion to social contact, which can be normalized by chronic, but not acute, administration of antidepressant...
  2. pmc Targeted manipulation of serotonergic neurotransmission affects the escalation of aggression in adult male Drosophila melanogaster
    Olga V Alekseyenko
    Neurobiology Department, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 5:e10806. 2010
    Dopamine (DA) and serotonin (5HT) are reported to serve important roles in aggression in a wide variety of animals...
  3. ncbi Girls' hyperactivity and physical aggression during childhood and adjustment problems in early adulthood: a 15-year longitudinal study
    Nathalie Fontaine
    Department of Psychology, University College London, London, England
    Arch Gen Psychiatry 65:320-8. 2008
    ..The co-occurrence of hyperactivity and conduct problems in childhood seems to increase the risk of early adulthood adjustment problems in males. However, little is known about this topic in females...
  4. pmc Identification of an aggression-promoting pheromone and its receptor neurons in Drosophila
    Liming Wang
    Division of Biology 216 76, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nature 463:227-31. 2010
    b>Aggression is regulated by pheromones in many animal species. However, in no system have aggression pheromones, their cognate receptors and corresponding sensory neurons been identified...
  5. ncbi Identification of protein pheromones that promote aggressive behaviour
    Pablo Chamero
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92030, USA
    Nature 450:899-902. 2007
    ..emitted and detected by members of the same species, as cues to regulate social behaviours such as pup suckling, aggression and mating...
  6. ncbi Dysfunction in the neural circuitry of emotion regulation--a possible prelude to violence
    R J Davidson
    Laboratory for Affective Neuroscience and W M Keck Laboratory for Functional Brain Imaging and Behavior, University of Wisconsin Madison, Madison, WI 53706, USA
    Science 289:591-4. 2000
    ..We posit that impulsive aggression and violence arise as a consequence of faulty emotion regulation...
  7. pmc Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression
    C Marquez
    Laboratory of Behavioral Genetics, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Transl Psychiatry 3:e216. 2013
    ..We present a novel animal model for pathological aggression induced by peripubertal exposure to stress with face, construct and predictive validity...
  8. ncbi Modulation of Fgfr1a signaling in zebrafish reveals a genetic basis for the aggression-boldness syndrome
    William H J Norton
    Zebrafish Neurogenetics, Laboratory of Neurobiology and Development, Institut de Neurobiologie Alfred Fessard, Unité Propre de Recherche 3294, CNRS, Avenue de la Terrasse, Gif sur Yvette, 91190, France
    J Neurosci 31:13796-807. 2011
    Behavioral syndromes are suites of two or more behaviors that correlate across environmental contexts. The aggression-boldness syndrome links aggression, boldness, and exploratory activity in a novel environment...
  9. pmc Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression
    Dongsha Wang
    Sainte Justine Hospital Research Center, Montreal, Quebec, Canada
    PLoS ONE 7:e39501. 2012
    ..brain serotonin (5-HT) synthesis, we found in a longitudinal sample that adult males with high childhood-limited aggression (C-LHPA) had lower in vivo 5-HT synthesis in the orbitofrontal cortex (OBFC)...
  10. ncbi Violent video game effects on aggression, empathy, and prosocial behavior in eastern and western countries: a meta-analytic review
    Craig A Anderson
    Department of Psychology, W112 Lagomarcino Hall, Iowa State University, Ames, IA 50011, USA
    Psychol Bull 136:151-73. 2010
    ..Results of various sensitivity analyses revealed these effects to be robust, with little evidence of selection (publication) bias...
  11. ncbi Neural mechanisms of aggression
    Randy J Nelson
    Department of Psychology, Institute for Behavioural Medicine Research, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Rev Neurosci 8:536-46. 2007
    Unchecked aggression and violence exact a significant toll on human societies. Aggression is an umbrella term for behaviours that are intended to inflict harm...
  12. pmc Hierarchical chemosensory regulation of male-male social interactions in Drosophila
    Liming Wang
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    Nat Neurosci 14:757-62. 2011
    ..hydrocarbon that was previously shown to inhibit male-male courtship, was essential for normal levels of aggression. The mechanisms by which (z)-7-tricosene induced aggression and suppressed courtship were independent, but both ..
  13. pmc Hippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats
    Christine Kohl
    Laboratory of Behavioral Genetics, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    PLoS ONE 8:e56871. 2013
    ..in associated behavioral alterations including changes in social and emotional behavior as well as abnormal aggression. Neuronal cell adhesion molecules (nCAMs) and mutations in these genes were found to be strongly implicated in ..
  14. pmc Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males
    Cindy F Yang
    Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 153:896-909. 2013
    ..Strikingly, the corresponding ablation in males reduces mating and aggression. Our findings reveal the functions of a molecularly defined, sexually dimorphic neuronal population in the brain...
  15. ncbi Ultrasonic vocalizations of rats (Rattus norvegicus) during mating, play, and aggression: Behavioral concomitants, relationship to reward, and self-administration of playback
    Jeffrey Burgdorf
    Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University
    J Comp Psychol 122:357-67. 2008
    ..In this study, high frequency recordings of ultrasonic vocalizations were made during mating, aggression, and both conspecific and heterospecific (dubbed "tickling") rough-and-tumble play behavior...
  16. ncbi Testosterone and dominance in men
    A Mazur
    Public Affairs Program, Syracuse University, NY 13244, USA
    Behav Brain Sci 21:353-63; discussion 363-97. 1998
    ..We discuss sociological implications of these models...
  17. pmc Neurobiology of aggression and violence
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, NY, USA
    Am J Psychiatry 165:429-42. 2008
    ..43 million deaths worldwide annually. While violence can occur in many contexts, individual acts of aggression account for the majority of instances...
  18. ncbi Aggression by polyembryonic wasp soldiers correlates with kinship but not resource competition
    David Giron
    Department of Entomology, University of Georgia, Athens, Georgia 30602, USA
    Nature 430:676-9. 2004
    Kin selection theory predicts that individuals will show less aggression and more altruism towards relatives...
  19. pmc Dose-dependent effects of multiple acute cocaine injections on maternal behavior and aggression in Sprague-Dawley rats
    J M Johns
    Department of Psychiatry, University of North Carolina, Chapel Hill, N C 27599 7096, USA
    Dev Neurosci 20:525-32. 1998
    ..30 min following injections for maternal behavior (MB) towards 8 surrogate male pups on PPD 1 and PPD 3 and for aggression towards a male or female intruder in the presence of their litter on PPD 6 and PPD 10...
  20. pmc Functional identification of an aggression locus in the mouse hypothalamus
    Dayu Lin
    Division of Biology 216 76, California Institute of Technology, 1201 East California Boulevard, Pasadena, California 91125, USA
    Nature 470:221-6. 2011
    ..but the exact location of relevant cells within these regions, their requirement for naturally occurring aggression and their relationship to mating circuits have not been clear...
  21. ncbi One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats
    James C DeMar
    Brain Physiology and Metabolism Section, National Institute on Aging, and Child Psychiatry Branch, National Institutes of Health Bethesda, MD, 20892, USA
    J Lipid Res 47:172-80. 2006
    ..Performance on tests of locomotor activity, depression, and aggression was measured in that order during the ensuing 3 weeks, after which brain lipid composition was determined...
  22. ncbi Testosterone and human aggression: an evaluation of the challenge hypothesis
    John Archer
    Department of Psychology, University of Central Lancashire, Preston, Lancashire PR12HE, UK
    Neurosci Biobehav Rev 30:319-45. 2006
    ..assessed in relation to a version of the challenge hypothesis, originally proposed to account for testosterone-aggression associations in monogamous birds...
  23. ncbi Loss of sex discrimination and male-male aggression in mice deficient for TRP2
    Lisa Stowers
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 295:1493-500. 2002
    ..Moreover, we show that male mice deficient in TRP2 expression fail to display male-male aggression, and they initiate sexual and courtship behaviors toward both males and females...
  24. ncbi Primates--a natural heritage of conflict resolution
    F B de Waal
    Living Links, Center for the Advanced Study of Human and Ape Evolution, Yerkes Regional Primate Research Center, and Psychology Department, Emory University, Atlanta, GA 30322, USA
    Science 289:586-90. 2000
    The traditional notion of aggression as an antisocial instinct is being replaced by a framework that considers it a tool of competition and negotiation...
  25. ncbi The neurobiology of aggression and rage: role of cytokines
    Steven S Zalcman
    Department of Psychiatry, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Brain Behav Immun 20:507-14. 2006
    ..Present research is designed to further delineate the roles of cytokines in aggressive behavior and to begin to unravel the possible signaling pathways involved this process...
  26. ncbi Male management: Coping with aggression problems in male laboratory mice
    P L P Van Loo
    Department of Laboratory Animal Science, Utrecht University, PO Box 80 166, 3508 TD Utrecht, The Netherlands
    Lab Anim 37:300-13. 2003
    ..Further research, in particular into the effects of frequency, duration, type and severity of disturbances during an experiment on the degree of aggression, is recommended.
  27. pmc GABA(A) receptor signaling in the lateral septum regulates maternal aggression in mice
    Grace Lee
    Department of Zoology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Behav Neurosci 123:1169-77. 2009
    Maternal aggression (maternal defense) is a fierce aggression produced by lactating females toward intruders that plays an important role in protection of vulnerable offspring...
  28. ncbi The aggressive behavior scale: a new scale to measure aggression based on the minimum data set
    Christopher M Perlman
    Homewood Health Centre, Guelph, Ontario, Canada
    J Am Geriatr Soc 56:2298-303. 2008
    ..To examine the reliability and validity of the Aggressive Behavior Scale (ABS), derived from the Minimum Data Set (MDS 2.0)...
  29. ncbi Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism
    Mariaelvina Sala
    Department of Pharmacology, Chemotherapy and Medical Toxicology, Universita degli Studi di Milano, Milan, Italy
    Biol Psychiatry 69:875-82. 2011
    ..Accordingly, the OT (Oxt(-/-)) and the OT receptor null mice (Oxtr(-/-)) display autistic-like deficits in social behavior, increased aggression, and reduced ultrasonic vocalization.
  30. pmc The introduction history of invasive garden ants in Europe: integrating genetic, chemical and behavioural approaches
    Line V Ugelvig
    Centre for Social Evolution, Department of Biology, University of Copenhagen, Universitetsparken 15, 2100 Copenhagen, Denmark
    BMC Biol 6:11. 2008
    ..microsatellite analysis, chemical analysis of cuticular hydrocarbon profiles and behavioural observations of aggression behaviour...
  31. pmc Neurobiology of aggression and violence in schizophrenia
    Michael Soyka
    Psychiatric Hospital, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Schizophr Bull 37:913-20. 2011
    There is much evidence that schizophrenia patients have an increased risk for aggression and violent behavior, including homicide. The neurobiological basis and correlates of this risk have not been much studied...
  32. ncbi Management of agitation and aggression associated with Alzheimer disease
    Clive G Ballard
    King s College London, London, UK
    Nat Rev Neurol 5:245-55. 2009
    Agitation and aggression are frequently occurring and distressing behavioral and psychological symptoms of dementia (BPSD)...
  33. ncbi Facial structure is a reliable cue of aggressive behavior
    Justin M Carré
    Department of Psychology, Brock University, St Catharines, Ontario, Canada
    Psychol Sci 20:1194-8. 2009
    ..We recently showed that this metric is correlated with behavioral aggression in men...
  34. pmc Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress
    Sharyl L Fyffe
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 59:947-58. 2008
    ..This study demonstrates that deleting Mecp2 in a defined brain region is an excellent approach to map the neuronal origins of complex behaviors and provides new insight about the function of MeCP2 in specific neurons...
  35. ncbi Trajectories of boys' physical aggression, opposition, and hyperactivity on the path to physically violent and nonviolent juvenile delinquency
    D Nagin
    Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Child Dev 70:1181-96. 1999
    ..Four developmental trajectories were identified for the physical aggression, opposition, and hyperactivity externalizing behavior dimensions: a chronic problem trajectory, a high level ..
  36. ncbi Effects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin
    Alexa H Veenema
    Department of Behavioural Neuroendocrinology, Institute of Zoology, University of Regensburg, Regensburg, Germany
    Eur J Neurosci 24:1711-20. 2006
    Early life stress in humans enhances the risk for psychopathologies, including excessive aggression and violence...
  37. ncbi Omega-3 fatty acid deficiencies in neurodevelopment, aggression and autonomic dysregulation: opportunities for intervention
    Joseph R Hibbeln
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, 20892, USA
    Int Rev Psychiatry 18:107-18. 2006
    ..Ensuring optimal intakes of omega-3 fatty acids during early development and adulthood shows considerable promise in preventing aggression and hostility.
  38. pmc Vasopressin: behavioral roles of an "original" neuropeptide
    Heather K Caldwell
    Section on Neural Gene Expression, NIMH, NIH, DHHS, Bethesda, MD 20892, United States
    Prog Neurobiol 84:1-24. 2008
    ..Avp plays a prominent role in the regulation of aggression, generally of facilitating or promoting it...
  39. ncbi Serotonergic functioning and trait-impulsivity in attention-deficit/hyperactivity-disordered boys (ADHD): influence of rapid tryptophan depletion
    Florian Daniel Zepf
    Department of Child and Adolescent Psychiatry and Psychotherapy, J W Goethe University of Frankfurt a M, Germany
    Hum Psychopharmacol 23:43-51. 2008
    ..tryptophan depletion (RTD) and the ensuing reduction of central nervous levels of serotonin (5-HT) on reactive aggression with respect to personality factors comprising aspects of trait-impulsivity and -aggression in boys with ..
  40. ncbi Scoping workplace aggression in nursing: findings from an Australian study
    Gerald A Farrell
    School of Nursing and Midwifery, Faculty of Health Sciences, La Trobe University, Victoria, Australia
    J Adv Nurs 55:778-87. 2006
    This paper reports a study of workplace aggression among nurses in Tasmania, Australia...
  41. ncbi Cruelty's rewards: the gratifications of perpetrators and spectators
    Victor Nell
    Institute for Social and Health Sciences, University of South Africa, Pretoria, South Africa
    Behav Brain Sci 29:211-24; discussion 224-57. 2006
    ..It is nonetheless an essential step in developing effective strategies for the primary prevention of violence...
  42. ncbi Acute cocaine alters oxytocin levels in the medial preoptic area and amygdala in lactating rat dams: implications for cocaine-induced changes in maternal behavior and maternal aggression
    J C Elliott
    Department of Psychology, University of North Carolina at Chapel Hill, NC 27599 3270, USA
    Neuropeptides 35:127-34. 2001
    ..body of evidence suggests that cocaine may alter oxytocin levels leading to impairments in maternal behavior and aggression. The current study assessed whether acute cocaine injections alter oxytocin (OT) levels in the medial preoptic ..
  43. ncbi Does sexual selection explain human sex differences in aggression?
    John Archer
    School of Psychology, University of Central Lancashire, Preston, United Kingdom
    Behav Brain Sci 32:249-66; discussion 266-311. 2009
    I argue that the magnitude and nature of sex differences in aggression, their development, causation, and variability, can be better explained by sexual selection than by the alternative biosocial version of social role theory...
  44. pmc Stress reduction through consolation in chimpanzees
    Orlaith N Fraser
    Research Centre in Evolutionary Anthropology and Palaeoecology, School of Biological and Earth Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom
    Proc Natl Acad Sci U S A 105:8557-62. 2008
    Consolation, i.e., postconflict affiliative interaction directed from a third party to the recipient of aggression, is assumed to have a stress-alleviating function. This function, however, has never been demonstrated...
  45. pmc Reduced genetic variation and the success of an invasive species
    N D Tsutsui
    Department of Biology 0116, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0116, USA
    Proc Natl Acad Sci U S A 97:5948-53. 2000
    ..This loss is associated with reduced intraspecific aggression among spatially separate nests, and leads to the formation of interspecifically dominant supercolonies...
  46. ncbi Sex differences in aggression between heterosexual partners: a meta-analytic review
    J Archer
    Department of Psychology, University of Central Lancashire, United Kingdom
    Psychol Bull 126:651-80. 2000
    Meta-analyses of sex differences in physical aggression to heterosexual partners and in its physical consequences are reported. Women were slightly more likely (d = -...
  47. pmc Seasonal differences of gene expression profiles in song sparrow (Melospiza melodia) hypothalamus in relation to territorial aggression
    Motoko Mukai
    Department of Neurobiology, Physiology, and Behavior, University of California Davis, Davis, California, United States of America
    PLoS ONE 4:e8182. 2009
    ..Microarrays, spotted with EST cDNA clones of zebra finch, were used to explore gene expression profiles in the hypothalamus after territorial aggression in two different seasons.
  48. ncbi Ant nestmate and non-nestmate discrimination by a chemosensory sensillum
    Mamiko Ozaki
    Department of Applied Biology, Faculty of Textile Science, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    Science 309:311-4. 2005
    ..For ants, cuticular hydrocarbon (CHC) blends produced by non-nestmates elicit overt aggression. We describe a sensory sensillum on the antennae of the carpenter ant Camponotus japonicus that functions in ..
  49. pmc Serotonin 5-HT(2) and 5-HT(1A)-like receptors differentially modulate aggressive behaviors in Drosophila melanogaster
    O Johnson
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Neuroscience 158:1292-300. 2009
    ..Significantly, these receptors mediate important behaviors in mammalian systems ranging from feeding, aggression, and sleep, to cognition...
  50. ncbi Genetics of human aggressive behaviour
    Ian W Craig
    SGDP Centre, Institute of Psychiatry, Denmark Hill, PO 82, London SE5 8AF, UK
    Hum Genet 126:101-13. 2009
    A consideration of the evolutionary, physiological and anthropological aspects of aggression suggests that individual differences in such behaviour will have important genetic as well as environmental underpinning...
  51. pmc A cross-national profile of bullying and victimization among adolescents in 40 countries
    Wendy Craig
    Department of Psychology, Queen s University, Ontario, Canada
    Int J Public Health 54:216-24. 2009
    ..1) To compare the prevalence of bullying and victimization among boys and girls and by age in 40 countries. (2) In 6 countries, to compare rates of direct physical, direct verbal, and indirect bullying by gender, age, and country...
  52. pmc Neurobiology of escalated aggression and violence
    Klaus A Miczek
    Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    J Neurosci 27:11803-6. 2007
    Psychopathological violence in criminals and intense aggression in fruit flies and rodents are studied with novel behavioral, neurobiological, and genetic approaches that characterize the escalation from adaptive aggression to violence...
  53. ncbi Trajectories of aggression from toddlerhood to age 9 predict academic and social functioning through age 12
    Susan B Campbell
    Department of Psychology, University of Pittsburgh, PA 15260, USA
    J Child Psychol Psychiatry 47:791-800. 2006
    ..examined behavior problems and social and academic outcomes from ages 9 through 12 in children classified into five trajectories of physical aggression, on the basis of maternal ratings obtained from 24 months through 9 years (N = 1195).
  54. pmc Inductive game theory and the dynamics of animal conflict
    Simon DeDeo
    Santa Fe Institute, Santa Fe, New Mexico, United States of America
    PLoS Comput Biol 6:e1000782. 2010
    ..An appreciation of the empirical foundations of the collective dynamics of conflict is a crucial step towards its effective management...
  55. ncbi Natural variation in a testosterone-mediated trade-off between mating effort and parental effort
    Joel W McGlothlin
    Department of Biology and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, Indiana 47405, USA
    Am Nat 170:864-75. 2007
    ..Initial testosterone levels were positively but nonsignificantly correlated with aggression but did not predict parental behavior...
  56. ncbi High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression
    Deborah K Sokol
    Department of Neurology, Indiana University School of Medicine, 702 Barnhill Drive, Indianapolis, IN 46202, USA
    J Child Neurol 21:444-9. 2006
    ..Children with severe autism and aggression expressed secreted beta-amyloid precursor protein at two or more times the levels of children without autism and ..
  57. ncbi Corticotropin-releasing factor inhibits maternal aggression in mice
    Stephen C Gammie
    Neuroscience Training Program, Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
    Behav Neurosci 118:805-14. 2004
    ..corticotropin-releasing factor (CRF), an activator of fear and anxiety, plays a functional role in maternal aggression. Intracerebroventricular (icv) injections of CRF (1.0 and 0.2 microg, but not 0...
  58. ncbi Aggressive behaviour by people with dementia in residential care settings: a review
    D Pulsford
    Division of Mental Health, Department of Nursing, University of Central Lancashire, Preston, UK
    J Psychiatr Ment Health Nurs 13:611-8. 2006
    ..behaviour is defined in the context of people with dementia, and the problem of ascertaining the incidence of aggression among people with dementia is discussed...
  59. ncbi Prosocial benefits of feeling free: disbelief in free will increases aggression and reduces helpfulness
    Roy F Baumeister
    Department of Psychology, Florida State University, Tallahassee, FL 32306, USA
    Pers Soc Psychol Bull 35:260-8. 2009
    ..a sense of thoughtful reflection and willingness to exert energy, thereby promoting helpfulness and reducing aggression, and so disbelief in free will may make behavior more reliant on selfish, automatic impulses and therefore less ..
  60. pmc Serotonin transporter expression is predicted by early life stress and is associated with disinhibited behavior in infant rhesus macaques
    E L Kinnally
    Department of Molecular Imaging and Neuropathology, Columbia University and New York State Psychiatric Institute, 1051 Riverside Drive, Room 2917, New York, NY 10032, USA
    Genes Brain Behav 9:45-52. 2010
    ..The present study investigated whether two types of early life stress, maternal and social aggression, and a serotonin transporter gene promoter polymorphism (rh5-HTTLPR) predicted lower post-stressor peripheral ..
  61. ncbi The presence of aggression cues inverts the relation between digit ratio (2D:4D) and prosocial behaviour in a dictator game
    Kobe Millet
    Department of Marketing and Organization Studies, Katholieke Universiteit Leuven, Leuven, Belgium
    Br J Psychol 100:151-62. 2009
    ..In two studies, we expose participants either to control or to aggression cues. Afterwards, they make a decision in a dictator game...
  62. ncbi Psychiatric comorbidity more common among adolescent females with CD/ODD than among males
    Pirkko Lehto-Salo
    Etela Savo District Hospital, Mikkeli, Finland
    Nord J Psychiatry 63:308-15. 2009
    ..The varied problems and comorbid disorders among females with CD/ODD are important to recognize...
  63. ncbi Association between bullying and psychosomatic problems: a meta-analysis
    Gianluca Gini
    Universita di Padova, Dipartimento di Psicologia dello Sviluppo e della Socializzazione, Via Venezia, 8, 35131 Padova, Italy
    Pediatrics 123:1059-65. 2009
    ..OBJECTIVE. We performed a meta-analysis to quantify the association between involvement in bullying and psychosomatic complaints in the school-aged population...
  64. ncbi The activation of prefrontal cortical neurons in aggression--a double labeling study
    Jozsef Halasz
    Department of Behavioral Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 1083, Hungary
    Behav Brain Res 175:166-75. 2006
    ..Disparate human findings also show that this area is acutely activated by aggression under certain conditions...
  65. pmc GABA(B) receptor modulation of serotonin neurons in the dorsal raphé nucleus and escalation of aggression in mice
    Aki Takahashi
    Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    J Neurosci 30:11771-80. 2010
    ..in the brain has been studied more than any other neurotransmitter for its role in the neurobiological basis of aggression. However, which mechanisms modulate the 5-HT system to promote escalated aggression is not clear...
  66. ncbi Aggression, impulsivity, and suicide behavior: a review of the literature
    Yari Gvion
    Bar Ilan University Department of Psychology, Bar Ilan University, Ramat Gan, Israel
    Arch Suicide Res 15:93-112. 2011
    This article reviews the literature on the association between impulsivity aggression and suicide. The key words impulsivity, aggression, and suicide were entered into the pubmed, psychlit, and proqest databases...
  67. ncbi Disentangling structural brain alterations associated with violent behavior from those associated with substance use disorders
    Boris Schiffer
    Department of Forensic Psychiatry, University of Duisburg Essen, Germany
    Arch Gen Psychiatry 68:1039-49. 2011
    ..Thus, alterations in gray matter (GM) volume that have been reported to be correlates of violent behavior and/or psychopathy may instead be related to lifelong substance use disorders (SUDs)...
  68. ncbi Human aggression
    Craig A Anderson
    Department of Psychology, Iowa State University, Ames, Iowa 50011 3180, USA
    Annu Rev Psychol 53:27-51. 2002
    Research on human aggression has progressed to a point at which a unifying framework is needed...
  69. ncbi Testosterone, paternal behavior, and aggression in the monogamous California mouse (Peromyscus californicus)
    B C Trainor
    Department of Psychology, University of Wisconsin at Madison, Madison, Wisconsin 53706, USA
    Horm Behav 40:32-42. 2001
    Testosterone (T) mediates a trade-off, or negative correlation, between paternal behavior and aggression in several seasonally breeding avian species...
  70. ncbi Corticolimbic function in impulsive aggressive behavior
    Emil F Coccaro
    Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois
    Biol Psychiatry 69:1153-9. 2011
    ..This review focuses on three neural systems involved in impulsive/reactive aggression: 1) subcortical neural systems that support the production of aggressive impulses; 2) decision-making circuits ..
  71. ncbi State anger and prefrontal brain activity: evidence that insult-related relative left-prefrontal activation is associated with experienced anger and aggression
    E Harmon-Jones
    Department of Psychology, University of Wisconsin, Madison 53706, USA
    J Pers Soc Psychol 80:797-803. 2001
    ..The present experiment tested whether state-induced anger is associated with relative left-prefrontal activity and whether this prefrontal activity is also associated with aggression. Results supported these hypotheses.
  72. ncbi Modulation of aggression in male mice: influence of group size and cage size
    P L Van Loo
    Department of Laboratory Animal Science, Utrecht University, PO Box 80 166, 3508 TD, Utrecht, Netherlands
    Physiol Behav 72:675-83. 2001
    b>Aggression in group-housed male mice is known to be influenced by both cage size and group size. However, the interdependency of these two parameters has not been studied yet...
  73. ncbi Aggression in childhood and long-term unemployment in adulthood: a cycle of maladaptation and some protective factors
    K Kokko
    Department of Psychology, University of Jyvaskyla, Finland
    Dev Psychol 36:463-72. 2000
    ..study was designed to shed light on specific risk mechanisms and protective factors in the relation between aggression in childhood and long-term unemployment in adulthood...
  74. pmc Winning fights induces hyperaggression via the action of the biogenic amine octopamine in crickets
    Jan Rillich
    Institute for Neurobiologie, Freie University of Berlin, Berlin, Germany
    PLoS ONE 6:e28891. 2011
    ..We quantified the effect of experiencing successive wins on aggression in adult male crickets (Gryllus bimaculatus) by staging knockout tournaments and investigated its dependence on ..
  75. pmc Better safe than sorry--socio-spatial group structure emerges from individual variation in fleeing, avoidance or velocity in an agent-based model
    Ellen Evers
    Behavioural Biology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 6:e26189. 2011
    ..primates, subordinates often avoid interactions with potentially aggressive group members, thereby preventing aggression and subsequent fleeing...
  76. ncbi Individual differences in plasma catecholamine and corticosterone stress responses of wild-type rats: relationship with aggression
    A Sgoifo
    Department of Animal Physiology, University of Groningen, Haren, The Netherlands
    Physiol Behav 60:1403-7. 1996
    ..stressors were studied in male members of a strain of wild-type rats, widely differing in their level of aggression. The aggressiveness was preliminarily established by measuring the latency time to attack (ALT) a male intruder ..
  77. ncbi Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect
    M Sala
    Dipartimento di Biotecnologie mediche e Medicina traslazionale, Universita degli Studi di Milano, Milan, Italy
    J Neuroendocrinol 25:107-18. 2013
    ..including impaired sociability and preference for social novelty, impaired cognitive flexibility, and increased aggression. Similar to Oxtr(-/-) mice, the Oxtr(+/-) showed impaired sociability and preference for social novelty but, ..
  78. pmc The role of the serotonergic system at the interface of aggression and suicide
    M Bortolato
    Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, USA
    Neuroscience 236:160-85. 2013
    ..a brief overview of the anatomical distribution of the 5-HT-ergic system in the key brain areas that govern aggression and suicidal behaviours, the implication of 5-HT markers (5-HT receptors, transporter as well as synthetic and ..
  79. pmc Characterization of head transcriptome and analysis of gene expression involved in caste differentiation and aggression in Odontotermes formosanus (Shiraki)
    Qiuying Huang
    Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, Huazhong Agricultural University, Wuhan, China
    PLoS ONE 7:e50383. 2012
    ..To date, very little is known about genomic or transcriptomic data for caste differentiation and aggression in O. formosanus...
  80. pmc Social tolerance in wild female crested macaques (Macaca nigra) in Tangkoko-Batuangus Nature Reserve, Sulawesi, Indonesia
    Julie Duboscq
    Junior Research Group for Primate Sexual Selection, Reproductive Biology Unit, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, Goettingen, Germany
    Am J Primatol 75:361-75. 2013
    ..It also highlights the relevance of the social style concept in the assessment of the degree of tolerance/despotism in social systems...
  81. pmc Mutations in many genes affect aggressive behavior in Drosophila melanogaster
    Alexis C Edwards
    Department of Genetics, North Carolina State University, Raleigh, NC, USA
    BMC Biol 7:29. 2009
    ..While the role of neurotransmitters and a few other molecules in mediating and modulating levels of aggression is well established, it is likely that many additional genetic pathways remain undiscovered...
  82. ncbi Bullying among middle-school students in low and middle income countries
    Lila C Fleming
    Department of Global and Community Health, College of Health and Human Services, George MasonUniversity, Fairfax, Virginia, USA
    Health Promot Int 25:73-84. 2010
    ..Bullied students also reported higher rates of tobacco use, alcohol use, drug use and sexual intercourse...
  83. pmc Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection
    F W Albert
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Heredity (Edinb) 107:205-14. 2011
    ..We have previously identified several QTL influencing tameness and aggression in a cross between two lines of wild-derived, outbred rats (Rattus norvegicus) selected for their behavior ..
  84. ncbi Brain oxytocin correlates with maternal aggression: link to anxiety
    Oliver J Bosch
    Institute of Zoology, University of Regensburg, 93040 Regensburg, Germany
    J Neurosci 25:6807-15. 2005
    The oxytocinergic system is critically involved in the regulation of maternal behavior, which includes maternal aggression. Because aggression has been linked to anxiety, we investigated the maternal aggression and the role of brain ..
  85. ncbi Violence against primary health care workers in Al-Hassa, Saudi Arabia
    Abdel Hady El-Gilany
    Mansoura University, Mansoura 35516, Egypt
    J Interpers Violence 25:716-34. 2010
    ..Unmet needs of patients, overcrowding, and reaction to injury or illness were the leading contributing factors for violence. There is a need for violence prevention and control program in health care facilities...
  86. pmc Pathways to aggression in schizophrenia affect results of treatment
    Jan Volavka
    Department of Psychiatry, New York University School of Medicine, New York, NY, USA
    Schizophr Bull 37:921-9. 2011
    ..It is usually effective when aggressive behavior is related to psychotic symptoms. However, in many patients, aggression is at least partly based on other factors such as comorbid substance use disorder, comorbid antisocial ..
  87. ncbi Estimating aggression from emotionally neutral faces: which facial cues are diagnostic?
    Justin M Carré
    Department of Psychology, Brock University, St Catharines, Ontario L2S 3A1, Canada
    Perception 39:356-77. 2010
    ..Furthermore, observers' estimates of aggression from emotionally neutral faces are accurate and are highly correlated with the facial width-to-height ratio...
  88. ncbi Social regulation of aggression by pheromonal activation of Or65a olfactory neurons in Drosophila
    Weiwei Liu
    Beijing Normal University College of Life Sciences, Beijing, China
    Nat Neurosci 14:896-902. 2011
    ..However, prior social grouping of males reduces their aggression. We found olfactory communication to be important for modulating Drosophila aggression...
  89. pmc G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice
    Pablo Chamero
    Department of Physiology, University of Saarland School of Medicine, 66424 Homburg, Germany
    Proc Natl Acad Sci U S A 108:12898-903. 2011
    ..Furthermore, we show that Gαo is an essential requirement for the display of male-male territorial aggression as well as maternal aggression in mice...
  90. pmc Complex genetic architecture of Drosophila aggressive behavior
    Liesbeth Zwarts
    Laboratory of Developmental Genetics, Center for Human Genetics, Catholic University Leuven and Flemish Institute for Biotechnology, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 108:17070-5. 2011
    ..mutations associated with hyperaggressive behavior and showed extensive epistatic and pleiotropic effects on aggression, brain morphology, and genome-wide transcript abundance in head tissues...
  91. pmc Evidence for biological roots in the transgenerational transmission of intimate partner violence
    M I Cordero
    Laboratory of Behavioral Genetics, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Geneva, CH, Switzerland
    Transl Psychiatry 2:e106. 2012
    ..Their offspring also showed increased aggression toward females in the absence of postnatal father-offspring interaction or any other exposure to violence...
  92. ncbi Fish can infer social rank by observation alone
    Logan Grosenick
    Department of Biological Sciences, Stanford University, Stanford, California, 94305, USA
    Nature 445:429-32. 2007
    ..Rather, animals probably use multiple domain-specific representations adapted to different social and ecological pressures that they encounter during the course of their natural lives...
  93. ncbi Neonatal exposure to endocrine active compounds or an ERbeta agonist increases adult anxiety and aggression in gonadally intact male rats
    Heather B Patisaul
    Department of Zoology, North Carolina State University, 127 David Clark Labs, Raleigh, NC 27695, USA
    Horm Behav 53:580-8. 2008
    ..endpoints but less is known about how they might affect other hormone dependent behaviors including anxiety and aggression. Recent evidence suggests that these effects may be mediated through the beta form of the estrogen receptor (..
  94. ncbi Dorsolateral prefrontal cortex and hippocampus sustain impulsivity and aggressiveness in borderline personality disorder
    M Sala
    Department of Mental Health, Azienda Sanitaria Locale Alessandria, Alessandria Italy
    J Affect Disord 131:417-21. 2011
    ..In this study we aimed at investigating whether hippocampus and DLPFC anatomy may sustain impulsive and aggressive behaviours in BPD...
  95. ncbi Reproductive system, social organization, human disturbance and ecological dominance in native populations of the little fire ant, Wasmannia auropunctata
    Julien Foucaud
    INRA, UMR CBGP, INRA IRD Cirad Montpellier SupAgro, Montferrier sur Lez, France
    Mol Ecol 18:5059-73. 2009
    ..and mtDNA data indicated that dominant and non-dominant native populations (supercolonies as determined by aggression tests) of W. auropunctata did not belong to different evolutionary units...
  96. ncbi Association of polymorphisms of the serotonergic pathways with clinical traits of impulsive-aggression and suicidality in adolescents: a multi-center study
    Gil Zalsman
    Child and Adolescent Psychiatry Division, Geha Mental Health Center, Petach Tikva, Israel
    World J Biol Psychiatry 12:33-41. 2011
    ..Suicidal behaviour runs in families. This study evaluated association between common polymorphisms in the serotonergic and adrenergic candidate genes (HTR2A, 5HTTLPR, and MAOA) and suicidality, psychopathology and aggression in adolescents.
  97. ncbi Winning fights elevates testosterone levels in California mice and enhances future ability to win fights
    Temitayo O Oyegbile
    Department of Psychology, University of Wisconsin, 1202 West Johnson Street, Madison, WI 53706, USA
    Horm Behav 48:259-67. 2005
    ..We hypothesize a 'winner-challenge' effect in which increased T levels serve to reinforce the winner effect in male California mice...
  98. ncbi Courtship, aggression and avoidance: pheromones, receptors and neurons for social behaviors in Drosophila
    Anupama Dahanukar
    Department of Entomology, University of California, Riverside, CA, USA
    Fly (Austin) 5:58-63. 2011
    ..for social behaviors required for survival and reproduction, such as con-specific recognition, courtship, aggression and avoidance of odor from "stressed" flies...
  99. pmc Fluoxetine treatment of alcoholic perpetrators of domestic violence: a 12-week, double-blind, randomized, placebo-controlled intervention study
    David T George
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bldg 10, Clinical Research Center, 10 Center Drive, Bethesda, MD 20892 1540, USA
    J Clin Psychiatry 72:60-5. 2011
    ..the effects of a selective serotonin reuptake inhibitor on the irritability subscale score of the Modified Overt Aggression Scale...
  100. ncbi Neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus
    Yumiko Kito
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, D3 2 2 Yamadaoka, Suita City, Osaka, Japan
    Behav Neurol 21:165-74. 2009
    ..To clarify the characteristics of neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus (iNPH)...
  101. ncbi Opposing hormonal mechanisms of aggression revealed through short-lived testosterone manipulations and multiple winning experiences
    Brian C Trainor
    Department of Psychology, University of Wisconsin at Madison, Madison, WI 53706, USA
    Horm Behav 45:115-21. 2004
    Territorial aggression is influenced by many social and environmental factors...

Research Grants79

  1. Effects of Testosterone and Genetic Factors on Psychological and Motor Function i
    NICOLE RENEE TARTAGLIA; Fiscal Year: 2013
    ..psychological factors (executive function, attention/inhibition, verbal fluency), behavior (social adjustment, aggression) and motor skills (strength, coordination) in testosterone versus placebo after 6 and 12 months of therapy...
  2. Neuropeptide modulation of biogenic amine function and aggression in a crustacean
    Maria A Sosa; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Neuropeptide modulation of biogenic amine function and aggression in a crustacean...
  3. Environmental regulation of estrogen dependent aggression
    Brian C Trainor; Fiscal Year: 2013
    ..This suggests that estrogens may decrease aggression by driving transcription...
  4. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..frequently in women, but deficits in serotonin in men often underlie irritability, hostility, anger, rage, and aggression leading to violence...
  5. Genetic and Optogenetic Models to Dissect the Role of the Serotonin 1B Receptor
    Katherine M Nautiyal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aggression and impulsivity are two understudied aspects of behavior that are significant symptoms in a number of psychiatric disorders...
  6. How do Amine Neurons Work?
    Edward A Kravitz; Fiscal Year: 2013
    ..Arousal, reward, learning and memory, risk taking behavior, aggression and stress related behavioral and physiological responses are some of the multitude of essential human behaviors ..
  7. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2012
    ..dementia seen in AD, many patients exhibit a range of non-cognitive symptoms that include depression, aggression, delusions and hallucinations...
  8. Biomarkers in HPA axis and inflammatory pathways for suicidal behavior in youth
    Nadine M Melhem; Fiscal Year: 2013
    ..These biological measures will be associated with increased sleep disturbances, impulsive aggression, emotion dysregulation, and reduced distress tolerance...
  9. Anabolic-androgenic steroids enhance motivation
    Ruth I Wood; Fiscal Year: 2013
    ..We hope to understand why AAS abuse predisposes individuals to engage in inappropriate and excessive aggression, sexual behavior and drug use, and to unravel the underlying neural mechanisms...
  10. Brain aromatase availability in steroid users: PET studies with [11C]vorozole
    Thomas B Hildebrandt; Fiscal Year: 2013
    ..desirable psychological and behavioral effects of AAS use that include increases in social dominance, sex drive, aggression, goal directed behavior, and self-esteem, which all share a common increase in behavioral disinhibition...
  11. Implementation of Microfluidic Automation for Large-Scale Searches of Olfactory N
    Albert Folch; Fiscal Year: 2012
    ..are volatile organic compounds that elicit or modulate innate behaviors such as mating, rearing of young, aggression and territory marking...
  12. Novel Therapeutics in PTSD: A Randomized Clinical Trial of Mifepristone
    Gerardo Villarreal; Fiscal Year: 2013
    ..untreated or under-treated, it can become a chronic condition associated with significant distress, depression, aggression, family disruption, and substance abuse...
  13. Mapping Etiological Pathways to SV Perpetration from Childhood to Young Adulthood
    Michele Ybarra; Fiscal Year: 2011
    ..General sexual aggression has been measured at each wave with the following question: "In the past 12 months, have you kissed, touched, or ..
  14. Metabolic Effects of Antipsychotics in Children
    John W Newcomer; Fiscal Year: 2010
    ..The use of atypical antipsychotics in children is increasing, and has been stimulated by reported efficacy for aggression and irritability in a variety of psychiatric conditions...
  15. A Program of Research and Mentorship on Alcohol Use and Intimate Partner Violence
    Gregory L Stuart; Fiscal Year: 2013
    ..and learn the necessary skills to expand my program of research to the genetics of alcohol treatment and aggression. This will involve obtaining training in molecular genetics, advanced statistical modeling of genetic variants ..
  16. Octopamine Neuroanatomy and Functioning in Fruit Fly Social Behavior
    KYLE LYNN GOBROGGE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aggression is an innate behavioral trait that has numerous ecological functions...
  17. Interactions of MAO A with vulnerability factors for aggression
    Marco Bortolato; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Pathological aggression has a devastating socio-economic impact, and is a leading mortality in young male Americans...
  18. Hormonal Modulation of Aggression in Drosophila
    Edward A Kravitz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aggression is an innate behavior that is a nearly universal feature of the social behavior of animals...
  19. Validating a novel biomarker of clinical progression and survival in CLL
    Randall S Davis; Fiscal Year: 2013
    ..in the field was the discovery that CLL can be segregated into two major subtypes that differ in their clinical aggression according to the degree of somatic hypermutation in the immunoglobulin heavy-chain variable region (IGHV) gene...
  20. Neurobiology of Aggression Co-morbidity in Mouse Model of Idic15 Autism
    Matthew P Anderson; Fiscal Year: 2013
    ..diagnosed with autism spectrum disorders (ASDs) are, in addition to signature traits, often burdened by excess aggression (~70% incidence), but knowledge on how this co-morbidity develops and current treatment options are limited...
  21. NEURONAL CONTROL OF INTERACTIONS AMONG BEHAVIORS
    William B Kristan; Fiscal Year: 2013
    ..has been implicated in almost every conceivable physiologic or behavioral function-affect, aggression, appetite, cognition, emesis, endocrine function, gastrointestinal function, motor function, neurotropism, ..
  22. Suicide Endophenotypes and Molecular Mechanisms of Lithium Action
    Todd D Gould; Fiscal Year: 2013
    ..endophenotypes (deconstructed components of complex behavioral phenotypes) associated with suicide including aggression and impulsivity...
  23. Metrics and tools for phenotyping sociality and development in animal models
    Jeffrey C Schank; Fiscal Year: 2011
    ..Traditionally, behavioral phenotyping uses categorical measures, such as exploration, sleep, anxiety, feeding, aggression, etc...
  24. ADOLESCENT ANABOLIC STEROIDS, VASOPRESSIN AND AGGRESSION
    Richard H Melloni; Fiscal Year: 2013
    ..It is well documented that anabolic steroid use is associated with a higher incidence of aggression and violence, yet little is known about how these drugs produce the aggressive phenotype...
  25. Postnatal Serotonin Deficits in Behavioral Pathogenesis: A Novel Genetic Approach
    MEREDITH SORENSON WHITNEY; Fiscal Year: 2013
    ..Tph2CKO mice will be evaluated for changes in anxiety like behaviors, fear conditioning, and inter-male aggression. This study will take advantage of my innovative approaches to determine the importance, specifically, of ..
  26. From Child Maltreatment to Adolescent Substance Abuse: Risks, Protective Factors
    Penelope K Trickett; Fiscal Year: 2010
    ..or neglect is associated with substance abuse and a variety of other problems, including anxiety and depression;aggression and delinquency;cognitive delays and school achievement problems;problems with interpersonal relationships;and ..
  27. RNAi therapy for Huntingtons disease: safety & efficacy in the nonhuman primate
    Jodi L McBride; Fiscal Year: 2010
    ..limbs and neck), loss of short-term memory and emotional disturbances that can include anxiety, depression and aggression. RNA interference (RNAi) has recently emerged as a leading candidate approach to reduce expression of disease ..
  28. Quantitative Comparisons between genotypes and model species
    Lauren M McIntyre; Fiscal Year: 2013
    ..In addition, intoxication can increase aggression, cause impotence, and decrease sexual inhibition and locomotor skills...
  29. Synaptic Aromatase: a Novel Form of Estrogen Delivery
    Colin J Saldanha; Fiscal Year: 2012
    ..These endpoints include aggression, mood, balance, neuroprotection, and learning...
  30. First Step: Home/School Intervention for Preschoolers with Disruptive Behaviors
    HILL M WALKER; Fiscal Year: 2013
    ..will produce the following benefits: 1) amelioration and/or elimination of serious behavior problems such as aggression, opposition- defiance, and other indicators of emerging antisocial behavior and externalizing behavior disorders,..
  31. Interplay between intrinsic and extrinsic force and glioma aggression
    Matt Barnes; Fiscal Year: 2013
    ..Progress in this underdeveloped area will be important to reveal new and more successful avenues for brain tumor therapy. ..
  32. Self-complementary rAAV9 Systemic Gene Delivery Treatment for MPS Type IIIA
    Douglas M McCarty; Fiscal Year: 2013
    ..are typically asymptomatic at birth, but at age 1-4 begin to develop severe behavioral problems including aggression and sleep disturbances, and cognitive deterioration that progresses to dementia...
  33. Dynamic Interactions Between G Proteins and Calcium at SNARE Complexes
    Simon T Alford; Fiscal Year: 2013
    ..diseases, in which GPCR function is treated by pharmacological intervention, cover conditions ranging from aggression, depression and schizophrenia. Inhibitory presynaptic GPCRs alter synaptic function by many mechanisms...
  34. Social and Motivational Properties of Vasoactive Intestinal Polypeptide Circuits
    James L Goodson; Fiscal Year: 2013
    ..Specific Aim 2 will employ similar manipulations for tests of aggression and anxiety-like behavior in the highly territorial violet-eared waxbill (Uraeginthus granatina)...
  35. Coaching Parents to Manage Youth Stress through Recreation and Culture
    Howard C Stevenson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Academic disengagement and peer aggression among Black youth often reflect mismanagement of stereotype threat in classrooms and on playgrounds where the pressures of resolving coping stress conflicts ..
  36. Vasopressin in the regulation of serotonin and anxiety
    BENJAMIN DAVID ROOD; Fiscal Year: 2013
    ..Because affiliative behaviors such as mating as opposed to antagonistic behaviors such as inter-male aggression are known to activate AVP cells in the BNST, animals will be exposed to these respective stimuli and their ..
  37. X-linked Genes, Histone Modifications, and Behavior
    Jun Xu; Fiscal Year: 2013
    ..XY) on behaviors such as aggression. Jarid1c encodes a histone demethylase that represses expression of specific genes...
  38. Neurogenetic Model of Social Behavior Heterogeneity in Autism Spectrum Disorders
    Michael L Platt; Fiscal Year: 2010
    ..Our proposed research will first characterize variability in social reward, social attention, and social aggression in a natural population of rhesus macaques living in large groups on Cayo Santiago Island in Puerto Rico, then ..
  39. Integrative Neurobiology of Social Processes
    S Marc Breedlove; Fiscal Year: 2013
    ..on social behaviors in humans and other species, we hope to gain a better understanding of disorders such as autism, ADHD, anorexia and schizophrenia, as well as societal issues such as aggression and parental behavior.
  40. Circadian dysfunction and GSK3 in neurodegenerative disease
    Karen L Gamble; Fiscal Year: 2013
    ..a constellation of symptoms including late afternoon/evening hyperactivity, restlessness, confusion, and aggression, along with misaligned core body temperature and activity rhythms...
  41. Genetic components influencing the feline - human social bond
    Leslie A Lyons; Fiscal Year: 2011
    ..Various behaviors, such as boldness, novelty seeking, and aggression have been linked to genetic variation of the genes within these biological pathways in humans, primates, rodents,..
  42. Developmental Genetics of Serotonin Neuron Subtypes in Brain Reward Circuits
    Susan M Dymecki; Fiscal Year: 2010
    ..5HT) and are implicated in human disorders ranging from psychiatric conditions of mind, mood, aggression and drug-seeking behaviors to disorders of cardiorespiratory homeostasis...
  43. Transduction mechanisms and CNS targets of GC-D neurons
    Steven D Munger; Fiscal Year: 2013
    ..g., pheromones or social cues) can promote mating or aggression behaviors or can contribute to transmission of food preferences between individual mice...
  44. RNAi therapy for Huntingtons disease: safety &efficacy in the nonhuman primate
    Jodi L McBride; Fiscal Year: 2013
    ..limbs and neck), loss of short-term memory and emotional disturbances that can include anxiety, depression and aggression. RNA interference (RNAi) has recently emerged as a leading candidate approach to reduce expression of disease ..
  45. AUTOMATED METHODS TO SUPPORT THE DETECTION OF DEPRESSION IN DEMENTIA
    HOWARD D contact WACTLAR; Fiscal Year: 2010
    ..however, activity and behavioral correlates of depression such as verbal and motor agitation, physical aggression, care resistance, and food/fluid refusal become important markers of possible depression [Bielinski06]...
  46. TWO TYPES OF MONOAMINE OXIDASE
    Jean Chen Shih; Fiscal Year: 2013
    ..stages are critically important for monoamine oxidase (MAO) A to induce long-term effects on neuroplasticity and aggression through the regulation of serotonin (5-hydroxytryptamine, 5-HT) levels and the activation of 5-HT receptors in ..
  47. Long-term benefits of dog ownership: Effects on stress and social behavior
    Kristen Jacobson; Fiscal Year: 2013
    ..g., aggression, depression, prosocial behavior), person characteristics (e.g...
  48. Limbic-Basal Ganglia Circuitry in PTSD
    Ludise Malkova; Fiscal Year: 2013
    ..social behavior research still lacks appropriate animal models for social pathology that leads to inappropriate aggression, social anxiety/phobias, social withdrawal/detachment, impulsivity, or defensiveness...
  49. Genes, Brain, and Behavior in Human Aggression
    Nelly Alia-Klein; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Aggression toward others is a socially destructive behavior repeatedly perpetrated by individuals of distinct genetic cognitive and affective characteristics...
  50. Paternal Care, Affiliation and Vasopressin: Mechanisms of Monogamy
    Alexander G Ophir; Fiscal Year: 2012
    ..Monogamy is characterized by parental care, social affiliation, and territorial aggression. Unfortunately, most studies investigating specific mechanisms underlying monogamy typically focus on these ..
  51. Refining Borderline Personality Disorder Using Flexible Latent Variable Modeling
    MICHAEL NELSON HALLQUIST; Fiscal Year: 2011
    ..of severity, but that subtypes of the disorder will be identified on the basis of additional markers, including aggression, mistrustfulness, preoccupied attachment, and rejection sensitivity...
  52. Development of Personalized Assistive Technology to Improve Dementia Care at Home
    CHANTAL M F E KERSSENS; Fiscal Year: 2012
    ..is on ameliorating common behavioral and neuropsychiatric symptoms identified by caregivers, such as apathy, aggression and trouble with ADL...
  53. From Pheromone Receptors to Social Behaviors
    HUBERT O AMREIN; Fiscal Year: 2012
    ..system to elucidate the roles of pheromones and their receptors in social behaviors, such as courtship, mating, aggression etc...
  54. MOLECULAR GENETICS OF OLFACTION IN DROSOPHILA
    Trudy F Mackay; Fiscal Year: 2013
    ..Chemical signals also drive aggression, courtship and, in mammals, affiliative behaviors and parental care...
  55. Emotion processing: Risk for psychopathology
    Seth D Pollak; Fiscal Year: 2013
    ..stress undermines children's regulatory control of emotion processing, relevant to behaviors such as aggression and poor emotion regulation...
  56. Children's Responses to Sibling Death in NICU/PICU in 3 Racial/Ethnic Groups
    JoAnne M Youngblut; Fiscal Year: 2012
    ..Many children respond to a sibling's death with anger, aggression, guilt, depression, suicidal thoughts and attempts, anxiety, poor school performance distance from parents, and ..
  57. Integration and independence of neuroendocrine mechanisms of behavior
    Kimberly A Rosvall; Fiscal Year: 2011
    ..The proposed research will probe co-variation among these levels of organization, with a focus on aggression and sex steroid hormones...
  58. Cortactin Binding Partners in HNSCC Phenotypes
    CHRISTI LYNN FRENCH; Fiscal Year: 2013
    ..To determine the molecular interactions of cortactin that are important in promoting tumor aggression, I propose two specific aims: 1, to determine which cortactin binding interactions are critical for cortactin-..
  59. Dissecting Estrogen Control of Sexual Differentiation of the Brain
    Jessica Tollkuhn; Fiscal Year: 2010
    ..BNST), an important node in the neural circuits that generate sexually dimorphic behaviors such as mating and aggression. The BNST is reciprocally connected with the hypothalamus and amygdala, and its structure is sexually dimorphic, ..
  60. Insulin Resistance and Breast Cancer Prognosis in Black &White Women
    Derek LeRoith; Fiscal Year: 2013
    ..women with a newly diagnosed breast cancer, to investigate the links between insulin resistance, breast cancer aggression, and race...
  61. Alcohol Servers Applying Psychology
    ADAM JOHN WENDT; Fiscal Year: 2011
    ..to: 1) understand the effects of consumption of alcohol and other drugs on behavior, including intimidation, aggression, and sexual harassment;2) comprehend the impact of the physical environment on patron behavior;3) use proactive ..
  62. MI Youth Violence Prevention Center
    Marc A Zimmerman; Fiscal Year: 2013
    ..which provides counseling to adolescents who present in the ED with an intentional injury or history of aggression;4) Mentoring for adolescents adjudicated in family court;5) Clean and Green, which partners with neighborhood ..
  63. COCAINE & MATERNAL AGGRESSION--OXYTOCINERGIC MECHANISMS
    JOSEPHINE JOHNS; Fiscal Year: 2005
    ..Gestational cocaine (COC) treatment has been shown to increase aggression towards an intruder (maternal aggression) and reduce the levels of oxytocin (OXY) in the amygdala of rats on ..
  64. COCAINE AND MATERNAL NEGLECT: INTERGENERATIONAL EFFECTS
    JOSEPHINE JOHNS; Fiscal Year: 2003
    ..Chronic cocaine treatment also increases postpartum maternal aggression towards intruders to the extent that pups are often injured, while acute cocaine treatment decreases protection ..
  65. RELATION BETWEEN SPACE AND AGGRESSION IN RHESUS MACAQUES
    Frans De Waal; Fiscal Year: 1992
    ..The literature, however, suggest a more complex relation between space and aggression. A comparison between free-ranging temple monkeys in Kathmandu, monkeys in a large corral, and caged monkeys ..
  66. EVOLUTION OF MATING SYSTEMS
    PATRICIA GOWATY; Fiscal Year: 2000
    ..original funded K02 proposal described a research plan designed to evaluate the relationship of within family aggression, conflict, and cooperation to kinship asymmetries (from alternative reproductive tactics) and the relationship ..
  67. ANGER ESCALATION AND DEESCALATION IN AGGRESSIVE MEN
    RICHARD HEYMAN; Fiscal Year: 2000
    ..is to propose and test a model of anger escalation and de-escalation in couples with and without husband-to-wife aggression. This model integrates social learning, feminist, and systems theories...
  68. Neural Analysis of Maternal Aggression
    STEPHEN GAMMIE; Fiscal Year: 2006
    To help understand and mitigate human aggression, it is critical to develop appropriate animal models to understand all the different forms of aggression...
  69. Efficacy of Various Positive Reinforcers in the Treatment of Destructive Behavior
    HENRY ROANE; Fiscal Year: 2010
    ..g., self-injury, aggression) may impede the development of many individuals with disabilities...
  70. SEROTONIN AND IMPULSIVE AGGRESSION--TREATMENT CORRELATES
    EMIL COCCARO; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract): Human aggression constitutes a complex a multidetermined act which results in physical or verbal assault to others, self, or objects...
  71. Validation of a Laboratory Measure of Self-Aggression
    Michael McCloskey; Fiscal Year: 2005
    Research in the areas of suicide and self-aggression has traditionally relied on non-experimental methodologies (e.g., case studies and correlational findings)...
  72. Neural Correlates of Emotion
    N Keele; Fiscal Year: 2003
    ..We hypothesize that low serotonin-induced aggression is associated with (1) changes in other emotional behavior and (2) increased membrane excitability in amygdala ..
  73. Mutant studies of territorial aggression in Drosophila
    Edward Kravitz; Fiscal Year: 2002
    b>Aggression is a nearly universal feature of the behavior of social animals. In the wild, it is regularly used for access to food and shelter, for protection from predation and for selection of mates...
  74. BEHAVIORAL MECHANISM IN HIGH RISK POPULATIONS
    DON CHEREK; Fiscal Year: 2001
    ..We will define these three groups using laboratory measures of aggression and impulsivity...
  75. Physical Abuse and Child Aggression:Role of ANS Arousal
    Elana Gordis; Fiscal Year: 2006
    ..coursework and close mentoring with experts in research on child abuse, domestic violence, psychophysiology, aggression,, measurement design, and multi-variate data analysis...
  76. Sexual Aggression and HIV Risk in Young Heterosexual Men
    ZOE PETERSON; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Rape and sexual assault are highly prevalent, and sexual aggression potentially places men and their unwilling female partners at risk for HIV and other sexually transmitted infections (STIs)...
  77. Promoting Sibling Bonds in Foster Care
    LOURDES ORIANA LINARES; Fiscal Year: 2010
    ..adversity, foster children are a high-risk population for negative sibling relationships and frequent physical aggression toward a sibling leading to increased risk for physical aggression toward other children i.e., non sibling peers...
  78. AGGRESSION AND VIOLENCE IN COMMUNITY BASED AD FAMILIES
    Gregory Paveza; Fiscal Year: 1999
    ..behavior; (3) to determine specific patient and caregiver characteristics that place families at risk for aggression and violence; (4) to specify characteristics that tend to prohibit the development of violence or aggression in ..
  79. Health Risk Behavior in Late Childhood: Impact of Longitudinal Randomized Trial
    STEPHANIE contact JONES; Fiscal Year: 2010
    ..The transition from elementary to middle school entails increased likelihood of health risk behaviors including aggression/violence, depression, substance use, and school disengagement/failure...