animal behavior

Summary

Summary: The observable response an animal makes to any situation.

Top Publications

  1. ncbi Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
    Luca Santarelli
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Science 301:805-9. 2003
  2. ncbi A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila
    S C Renn
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Cell 99:791-802. 1999
  3. ncbi Genetics of mouse behavior: interactions with laboratory environment
    J C Crabbe
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97201, USA
    Science 284:1670-2. 1999
  4. ncbi Applications of the Morris water maze in the study of learning and memory
    R D'hooge
    Laboratory of Neurochemistry and Behavior, Born Bunge Foundation, and Department of Neurology Memory Clinic, Middelheim Hospital, University of Antwerp, Universiteitsplein 1, B 2610, Antwerp, Belgium
    Brain Res Brain Res Rev 36:60-90. 2001
  5. ncbi Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS
    Paul Willner
    Department of Psychology, University of Wales Swansea, Swansea, UK
    Neuropsychobiology 52:90-110. 2005
  6. ncbi Correlates of sleep and waking in Drosophila melanogaster
    P J Shaw
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 287:1834-7. 2000
  7. ncbi Coupled oscillators control morning and evening locomotor behaviour of Drosophila
    Dan Stoleru
    Howard Hughes Medical Institute and National Center for Behavioural Genomics, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 431:862-8. 2004
  8. ncbi Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007
  9. ncbi The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice
    John F Cryan
    Psychiatry Program, Neuroscience Research, The Novartis Institutes for BioMedical Research WSJ 386 344, Novartis Pharma AG, CH 4002 Basel, Switzerland
    Neurosci Biobehav Rev 29:571-625. 2005
  10. ncbi Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain
    Brigitte Grima
    Institut de Neurobiologie Alfred Fessard NGI, CNRS UPR 2216, Centre National de la Recherche Scientifique, av de la Terrasse, 91198 Gif sur Yvette, France
    Nature 431:869-73. 2004

Detail Information

Publications333 found, 100 shown here

  1. ncbi Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
    Luca Santarelli
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Science 301:805-9. 2003
    ..These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus...
  2. ncbi A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila
    S C Renn
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Cell 99:791-802. 1999
    ..These results confirm the assignment of LNv neurons as the principal circadian pacemakers controlling daily locomotion in Drosophila. They also implicate PDF as the principal circadian transmitter...
  3. ncbi Genetics of mouse behavior: interactions with laboratory environment
    J C Crabbe
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97201, USA
    Science 284:1670-2. 1999
    ..For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory...
  4. ncbi Applications of the Morris water maze in the study of learning and memory
    R D'hooge
    Laboratory of Neurochemistry and Behavior, Born Bunge Foundation, and Department of Neurology Memory Clinic, Middelheim Hospital, University of Antwerp, Universiteitsplein 1, B 2610, Antwerp, Belgium
    Brain Res Brain Res Rev 36:60-90. 2001
    ..Through its many applications, MWM testing gained a position at the very core of contemporary neuroscience research...
  5. ncbi Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS
    Paul Willner
    Department of Psychology, University of Wales Swansea, Swansea, UK
    Neuropsychobiology 52:90-110. 2005
    ....
  6. ncbi Correlates of sleep and waking in Drosophila melanogaster
    P J Shaw
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 287:1834-7. 2000
    ..These results implicate the catabolism of monoamines in the regulation of sleep and waking in the fly and suggest that Drosophila may serve as a model system for the genetic dissection of sleep...
  7. ncbi Coupled oscillators control morning and evening locomotor behaviour of Drosophila
    Dan Stoleru
    Howard Hughes Medical Institute and National Center for Behavioural Genomics, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 431:862-8. 2004
    ..Although the two oscillators can function autonomously, cell-specific rescue experiments with circadian clock mutants indicate that they are functionally coupled...
  8. ncbi Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007
    ..These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation...
  9. ncbi The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice
    John F Cryan
    Psychiatry Program, Neuroscience Research, The Novartis Institutes for BioMedical Research WSJ 386 344, Novartis Pharma AG, CH 4002 Basel, Switzerland
    Neurosci Biobehav Rev 29:571-625. 2005
    ..Taken together, we conclude that the tail suspension test is a useful test for assessing the behavioural effects of antidepressant compounds and other pharmacological and genetic manipulations relevant to depression...
  10. ncbi Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain
    Brigitte Grima
    Institut de Neurobiologie Alfred Fessard NGI, CNRS UPR 2216, Centre National de la Recherche Scientifique, av de la Terrasse, 91198 Gif sur Yvette, France
    Nature 431:869-73. 2004
    ..Furthermore, we show that the LN(v)s alone can generate 24 h activity rhythms in constant darkness, indicating that the morning oscillator is sufficient to drive the circadian system...
  11. ncbi The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
    A N Akopian
    Molecular Nociception Group, Department of Biology, Medawar Building, University College, London WC1E 6BT, UK
    Nat Neurosci 2:541-8. 1999
    ..These data show that SNS is involved in pain pathways and suggest that blockade of SNS expression or function may produce analgesia without side effects...
  12. ncbi High-speed imaging reveals neurophysiological links to behavior in an animal model of depression
    Raag D Airan
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Science 317:819-23. 2007
    ..through the dentate gyrus relative to the hippocampal output subfield-accounted for induced changes in animal behavior independent of the underlying mechanism of action of the treatments...
  13. ncbi Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life
    Ian C G Weaver
    Douglas Hospital Research Center, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 25:11045-54. 2005
    ..These results demonstrate that, despite the inherent stability of the epigenomic marks established early in life through behavioral programming, they are potentially reversible in the adult brain...
  14. ncbi The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking
    S Ikemoto
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Brain Res Brain Res Rev 31:6-41. 1999
    ..The present conceptual framework may be valuable in understanding the dynamic interplay of NAS DA neurochemistry and behavior, both normal and pathophysiological...
  15. pmc Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons
    Sara J Aton
    Department of Biology, One Brookings Drive, Washington University, St Louis, Missouri 63130, USA
    Nat Neurosci 8:476-83. 2005
    ..We conclude that VIP coordinates daily rhythms in the SCN and behavior by synchronizing a small population of pacemaking neurons and maintaining rhythmicity in a larger subset of neurons...
  16. ncbi The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review
    Laetitia Prut
    EA3248, Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite Francois Rabelias, Parc de Grandmont Avenue Monge, 37200 Tours, France
    Eur J Pharmacol 463:3-33. 2003
    ....
  17. ncbi Do early-life events permanently alter behavioral and hormonal responses to stressors?
    H Anisman
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Int J Dev Neurosci 16:149-64. 1998
    ..In contrast, in relatively hardy animals the early-life manipulations may have less obvious effects...
  18. ncbi Cognitive inflexibility after prefrontal serotonin depletion
    H F Clarke
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Science 304:878-80. 2004
    ....
  19. ncbi Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development
    G W Smith
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Neuron 20:1093-102. 1998
    ..These results suggest that CRFR1 plays an important role both in the development of a functional HPA axis and in mediating behavioral changes associated with anxiety...
  20. ncbi Influence of gene action across different time scales on behavior
    Y Ben-Shahar
    Department of Entomology, Neuroscience Program, University of Illinois at Urbana Champaign, 320 Morrill Hall, 505 South Goodwin Avenue, Urbana, IL 61801, USA
    Science 296:741-4. 2002
    ..Previous research showed that allelic differences in PKG expression result in two Drosophila foraging variants. The same gene can thus exert different types of influence on a behavior...
  21. ncbi PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors
    Inge Mertens
    Laboratory of Developmental Physiology, Genomics and Proteomics, K U Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Neuron 48:213-9. 2005
    ..These data establish the first synapse within the Drosophila circadian neural circuit and underscore the importance of Class II peptide GPCR signaling in circadian neural systems...
  22. ncbi The role of the basal ganglia in habit formation
    Henry H Yin
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, TS 13, Bethesda, Maryland 20892, USA
    Nat Rev Neurosci 7:464-76. 2006
    ..How are goal-directed actions transformed into habitual responses? Recent work combining modern behavioural assays and neurobiological analysis of the basal ganglia has begun to yield insights into the neural basis of habit formation...
  23. ncbi The use of behavioral test batteries: effects of training history
    K L McIlwain
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Physiol Behav 73:705-17. 2001
    ..These two studies demonstrate that some behavioral tests appear to be sensitive to previous testing experience, while other tests are immune...
  24. ncbi The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
    J Z Tsien
    Howard Hughes Medical Institute, Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 87:1327-38. 1996
    ..Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories...
  25. ncbi Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies
    L J Vanderschuren
    Research Institute Neurosciences Vrije Universiteit, Department of Pharmacology, Medical Faculty, Free University, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 151:99-120. 2000
    ....
  26. pmc Sex-specific programming of offspring emotionality after stress early in pregnancy
    Bridget R Mueller
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:9055-65. 2008
    ..Overall, these results indicate that stress experience early in pregnancy may contribute to male neurodevelopmental disorders through impacts on placental function and fetal development...
  27. ncbi Drosophila CRY is a deep brain circadian photoreceptor
    P Emery
    Department of Biology, National Science Foundation Center for Biological Timing, Waltham, Massachusetts 02454, USA
    Neuron 26:493-504. 2000
    ..These brain neurons therefore contain an identified deep brain photoreceptor, as well as the other circadian elements: a central pace-maker and a behavioral output system...
  28. pmc Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease
    Colm Cunningham
    Department of Biochemistry, Trinity College Institute of Neuroscience, Trinity College Dublin, Republic of Ireland
    Biol Psychiatry 65:304-12. 2009
    ....
  29. ncbi Increased depression-like behaviors in corticotropin-releasing factor receptor-2-deficient mice: sexually dichotomous responses
    Tracy L Bale
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 23:5295-301. 2003
    ....
  30. ncbi Effects of chronic fluoxetine in animal models of anxiety and depression
    Stephanie C Dulawa
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 29:1321-30. 2004
    ..In the forced swim test, 10 and 18 mg/kg/day increased swimming and reduced immobility. Here we present several novel effects of chronic, but not subchronic, antidepressant treatment...
  31. ncbi Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF
    Seogang Hyun
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Korea
    Neuron 48:267-78. 2005
    ..Therefore, we herein propose that Han is a PDF receptor regulating circadian behavioral rhythm through coordination of activities of clock neurons...
  32. ncbi Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression
    S C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, Box 0520, 503 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuroscience 131:759-68. 2005
    ..Therefore, zebrafish larvae represent a powerful new system to study the underlying basis of seizure generation, epilepsy and epileptogenesis...
  33. ncbi Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat
    Emma S J Robinson
    Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:1028-37. 2008
    ....
  34. ncbi Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning
    Henry H Yin
    Department of Psychology, and Brain Research Institute, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095 1563, USA
    Eur J Neurosci 19:181-9. 2004
    ..Furthermore, it suggests that, when the habit system is disrupted, control over instrumental performance reverts to the system controlling the performance of goal-directed instrumental actions...
  35. ncbi Altruistic helping in human infants and young chimpanzees
    Felix Warneken
    Department of Developmental and Comparative Psychology, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Science 311:1301-3. 2006
    ..This requires both an understanding of others' goals and an altruistic motivation to help. In addition, we demonstrate similar though less robust skills and motivations in three young chimpanzees...
  36. ncbi Reduced sleep in Drosophila Shaker mutants
    Chiara Cirelli
    Department of Psychiatry, 6001 Research Park Blvd, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    Nature 434:1087-92. 2005
    ..Shaker, which encodes a voltage-dependent potassium channel controlling membrane repolarization and transmitter release, may thus regulate sleep need or efficiency...
  37. ncbi vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock
    Shawn A Cyran
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Cell 112:329-41. 2003
    ..Thus, VRI and PDP1, together with dClock itself, comprise a second feedback loop in the Drosophila clock that gives rhythmic expression of dClock, and probably of other genes, to generate accurate circadian rhythms...
  38. pmc Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades
    Douglas Wahlsten
    Department of Psychology, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Proc Natl Acad Sci U S A 103:16364-9. 2006
    ..Phenotypic drift over decades for most of the behaviors examined appears to be minimal...
  39. ncbi Critical involvement of dopaminergic neurotransmission in impulsive decision making
    Marcel M van Gaalen
    Department of Medical Pharmacology, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, Free University Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 60:66-73. 2006
    ..Commonly prescribed for this condition, amphetamine (Adderall), reduces impulsive decision making; however, the neuropharmacologic mechanism of this effect of amphetamine is unclear...
  40. ncbi Memory reconsolidation and extinction have distinct temporal and biochemical signatures
    Akinobu Suzuki
    Department of Agricultural Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156 8502, Japan
    J Neurosci 24:4787-95. 2004
    ..These studies demonstrate the dynamic nature of memory processing after retrieval and represent a first step toward a molecular dissection of underlying mechanisms...
  41. ncbi Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia
    M V Pletnikov
    Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 13:173-86, 115. 2008
    ..The present mouse model may facilitate the study of aspects of the pathogenesis of schizophrenia...
  42. ncbi Breeding together: kin selection and mutualism in cooperative vertebrates
    Tim Clutton-Brock
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Science 296:69-72. 2002
    ....
  43. ncbi Complexity, pattern, and evolutionary trade-offs in animal aggregation
    J K Parrish
    Zoology Department, University of Washington, Seattle, WA 98195, USA
    Science 284:99-101. 1999
    ....
  44. pmc Deconstructing memory in Drosophila
    Carla Margulies
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Curr Biol 15:R700-13. 2005
    ..We have attempted to use this integrative approach to evaluate distinct mechanistic hypotheses, and to propose critical experiments that will advance this field...
  45. ncbi Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring
    Limin Shi
    Biology Division, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 23:297-302. 2003
    ..Therefore, maternal viral infection has a profound effect on the behavior of adult offspring, probably via an effect of the maternal immune response on the fetus...
  46. ncbi A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field
    E Choleris
    Room 9222D, Department of Psychology, Social Science Center, University of Western Ontario, London, Ontario, Canada N6A 5C2
    Neurosci Biobehav Rev 25:235-60. 2001
    ..Detailed ethological assessments of animal behavior are lacking...
  47. ncbi Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning
    Hsing Chen Tsai
    Neuroscience Program, W080 Clark Center, 318 Campus Drive West, Stanford University, Stanford, CA 94305, USA
    Science 324:1080-4. 2009
    ..These results demonstrate that phasic dopaminergic activity is sufficient to mediate mammalian behavioral conditioning...
  48. ncbi Visuomotor behaviors in larval zebrafish after GFP-guided laser ablation of the optic tectum
    Tobias Roeser
    Department of Physiology and Programs in Neuroscience, Genetics, Developmental Biology, and Human Genetics, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 23:3726-34. 2003
    ....
  49. pmc Correction of fragile X syndrome in mice
    Gul Dolen
    Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 56:955-62. 2007
    ..Our results demonstrate that mGluR5 contributes significantly to the pathogenesis of the disease, a finding that has significant therapeutic implications for fragile X and related developmental disorders...
  50. ncbi Honeybee navigation: nature and calibration of the "odometer"
    M V Srinivasan
    Centre for Visual Science, Research School of Biological Sciences, Australian National University, Canberra, ACT 2601, Australia
    Science 287:851-3. 2000
    ..The results show that the honeybee's "odometer" is visually driven. They also provide a calibration of the dance and the odometer in visual terms...
  51. pmc The endocannabinoid system controls key epileptogenic circuits in the hippocampus
    Krisztina Monory
    Department of Physiological Chemistry, Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
    Neuron 51:455-66. 2006
    ..The direct endocannabinoid-mediated control of hippocampal glutamatergic neurotransmission may constitute a promising therapeutic target for the treatment of disorders associated with excessive excitatory neuronal activity...
  52. ncbi The influence of visual landscape on the free flight behavior of the fruit fly Drosophila melanogaster
    Lance F Tammero
    UCB UCSF Joint Bioengineering Graduate Group, 3060 Valley Life Science Building, University of California at Berkeley, Berkeley, CA 94720, USA
    J Exp Biol 205:327-43. 2002
    ..In summary, our data suggest that complex behavioral patterns seen during free flight emerge from interactions between the flight control system and the visual environment...
  53. pmc Vasopressin: behavioral roles of an "original" neuropeptide
    Heather K Caldwell
    Section on Neural Gene Expression, NIMH, NIH, DHHS, Bethesda, MD 20892, United States
    Prog Neurobiol 84:1-24. 2008
    ..In this review, we concentrate on the scientific progress that has been made in understanding the role of Avp in regulating these and other behaviors across species. We also discuss the implications for human behavior...
  54. ncbi Designing mouse behavioral tasks relevant to autistic-like behaviors
    Jacqueline N Crawley
    Mouse Behavioral Phenotyping Laboratory, Neurodevelopmental Disorders Research Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Ment Retard Dev Disabil Res Rev 10:248-58. 2004
    ....
  55. pmc Drosophila free-running rhythms require intercellular communication
    Ying Peng
    Department of Biology, Brandeis University, Waltham, Massachusetts, USA
    PLoS Biol 1:E13. 2003
    ..The cooperative function of this network appears to be necessary for maintaining robust molecular oscillations in DD and is the basis of sustained circadian locomotor activity rhythms...
  56. ncbi Neurons regulating the duration of forward locomotion in Caenorhabditis elegans
    Tokumitsu Wakabayashi
    Laboratory of Bioscience, Faculty of Engineering, Iwate University, 4 3 5 Ueda, Morioka 020 8551, Japan
    Neurosci Res 50:103-11. 2004
    ..Loss of any one of these neurons altered the locomotory behavior...
  57. ncbi The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 163:362-80. 2002
    ..The developmental history and application of the 5-choice serial reaction time task (5CSRTT) for measuring effects of drugs and other manipulations on attentional performance (and stimulus control) in rats is reviewed...
  58. ncbi Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens
    Jeremy J Day
    Department of Psychology, Davie Hall CB no 3270, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Neurosci 10:1020-8. 2007
    ..Consistent with proposed roles in reward prediction and incentive salience, these results indicate that rapid dopamine release provides a reward signal that is dynamically modified by associative learning...
  59. pmc A behavioral switch: cGMP and PKC signaling in olfactory neurons reverses odor preference in C. elegans
    Makoto Tsunozaki
    Howard Hughes Medical Institute, Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA
    Neuron 59:959-71. 2008
    ..These results suggest that alternative modes of neurotransmission can couple one sensory neuron to opposite behavioral outputs...
  60. ncbi Behavioral theories and the neurophysiology of reward
    Wolfram Schultz
    Department of Anatomy, University of Cambridge, CB2 3DY United Kingdom
    Annu Rev Psychol 57:87-115. 2006
    ..The neural activity can be related to basic theoretical terms of reward and uncertainty, such as contiguity, contingency, prediction error, magnitude, probability, expected value, and variance...
  61. pmc Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants
    Tohei Yokogawa
    Howard Hughes Medical Institute, Stanford University, Palo Alto, California, USA
    PLoS Biol 5:e277. 2007
    ..Our study validates the use of zebrafish for the study of sleep and indicates molecular diversity in sleep regulatory networks across vertebrates...
  62. ncbi Involvement of the endocannabinoid system in drug addiction
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Carrer Dr Aiguader 80, 08003 Barcelona, Spain
    Trends Neurosci 29:225-32. 2006
    ..In agreement, clinical trials have suggested that the CB(1) cannabinoid antagonist rimonabant can cause smoking cessation. Thus, CB(1) cannabinoid antagonists could represent a new generation of compounds to treat drug addiction...
  63. ncbi Chimpanzees recruit the best collaborators
    Alicia P Melis
    Max Planck Institute for Evolutionary Anthropology, Leipzig, D 04103, Germany
    Science 311:1297-300. 2006
    ....
  64. ncbi Exposure to acute stress blocks the induction of long-term potentiation of the amygdala-prefrontal cortex pathway in vivo
    Mouna Maroun
    The Brain and Behavior Center, Faculty of Science and Science Education, University of Haifa, Haifa, 31905, Israel
    J Neurosci 23:4406-9. 2003
    ....
  65. ncbi In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice
    J F Cryan
    Neuroscience Research, The Novartis Institutes for BioMedical Research, Basel, Switzerland
    Mol Psychiatry 9:326-57. 2004
    ....
  66. ncbi Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila
    Krisztina Foltenyi
    Department of Biology, University of California San Diego, 9500 Gilman Dr, La Jolla, California 92093, USA
    Nat Neurosci 10:1160-7. 2007
    ..These results suggest that sleep and its regulation by EGFR signaling may be ancestral to insects and mammals...
  67. ncbi Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia
    K A Sluka
    Physical Therapy Graduate Program, 2600 Steindler Bldg, University of Iowa, Iowa City, Iowa 52242, USA
    Muscle Nerve 24:37-46. 2001
    ..2. Thus, this new model of widespread, chronic muscle-induced pain is unrelated to tissue damage and is not maintained by continued primary afferent input from the site of injury...
  68. ncbi Midbrain dopamine neurons encode decisions for future action
    Genela Morris
    Interdisciplinary Center for Neural Computation ICNC, Hebrew University, Jerusalem, Israel
    Nat Neurosci 9:1057-63. 2006
    ....
  69. ncbi Coordinated memory replay in the visual cortex and hippocampus during sleep
    Daoyun Ji
    The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 10:100-7. 2007
    ..These results imply simultaneous reactivation of coherent memory traces in the cortex and hippocampus during sleep that may contribute to or reflect the result of the memory consolidation process...
  70. ncbi Causes and consequences of animal dispersal strategies: relating individual behaviour to spatial dynamics
    Diana E Bowler
    UUniversity of Aberdeen, School of Biological Sciences, Tillydrone Avenue, Aberdeen
    Biol Rev Camb Philos Soc 80:205-25. 2005
    ..Further studies are necessary to explore the importance of incorporating specific condition-dependent dispersal strategies for evolutionary and population dynamic predictions...
  71. ncbi Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Neurosci 11:1153-61. 2008
    ....
  72. pmc Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit
    Michael Y Chao
    Massachusetts General Hospital Center for Cancer Research, 149 7202 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:15512-7. 2004
    ..Our results demonstrate that 5-HT modulation of neuronal activity via G protein signaling underlies behavioral plasticity by rapidly altering the functional circuitry of a chemosensory circuit...
  73. pmc Large ventral lateral neurons modulate arousal and sleep in Drosophila
    Vasu Sheeba
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    Curr Biol 18:1537-45. 2008
    ..To determine whether the lLNvs are involved in arousal and sleep/wake behavior, we examined the effects of altered electrical excitation of the LNvs...
  74. ncbi A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless
    R Allada
    NSF, Center for Biological Timing, and Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    Cell 93:791-804. 1998
    ..The remarkable sequence conservation strongly supports common clock components present in the common ancestor of Drosophila and mammals...
  75. ncbi The genetic basis of individual-recognition signals in the mouse
    Sarah A Cheetham
    Mammalian Behaviour and Evolution Group, Department of Veterinary Preclinical Science, University of Liverpool, Leahurst, Neston CH64 7TE, United Kingdom
    Curr Biol 17:1771-7. 2007
    ..Specific signals for genetic identity recognition in other species now need to be investigated...
  76. ncbi Functional ethanol tolerance in Drosophila
    H Scholz
    Department of Anatomy, University of California, San Francisco 94143, USA
    Neuron 28:261-71. 2000
    ..Taken together, these data show that Drosophila is a suitable model system in which to study the molecular and neuroanatomical bases of ethanol tolerance...
  77. ncbi Culture in whales and dolphins
    L Rendell
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Behav Brain Sci 24:309-24; discussion 324-82. 2001
    ..We hope to stimulate discussion and research on culture in these animals...
  78. ncbi Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine
    R Ranganathan
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 21:5871-84. 2001
    ..Further analysis of the MOD-5-independent behavioral effects of fluoxetine could lead to the identification of novel targets of fluoxetine and could facilitate the development of more specific human pharmaceuticals...
  79. ncbi Shaping of hooks in New Caledonian crows
    Alex A S Weir
    Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
    Science 297:981. 2002
  80. pmc Mutations in many genes affect aggressive behavior in Drosophila melanogaster
    Alexis C Edwards
    Department of Genetics, North Carolina State University, Raleigh, NC, USA
    BMC Biol 7:29. 2009
    ..Here, we present the results of a screen of 170 Drosophila P-element insertional mutations for quantitative differences in aggressive behavior from their co-isogenic control line...
  81. pmc Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
    A Zimmer
    Laboratory of Genetics, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:5780-5. 1999
    ..Thus, most, but not all, CNS effects of Delta9-THC are mediated by the CB1 receptor...
  82. pmc Hypoxia activates a latent circuit for processing gustatory information in C. elegans
    Roger Pocock
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University Medical Center, New York, New York, USA
    Nat Neurosci 13:610-4. 2010
    ..Thus, physiological detection of hypoxia results in the activation of an additional, previously unrecognized circuit for processing sensory information that is not required for sensory processing under normoxic conditions...
  83. pmc The effect of Toxoplasma gondii on animal behavior: playing cat and mouse
    Joanne P Webster
    Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, St Mary s Campus, Norfolk Place, London, UK
    Schizophr Bull 33:752-6. 2007
    ..This article reviews evidence of behavioral alterations in animal hosts and considers what these may elucidate about the potential mechanisms involved and what implications such alterations could have on animal and human health...
  84. ncbi Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response control
    Tommy Pattij
    Department of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 191:587-98. 2007
    ..Impaired inhibitory control over behavior is a key feature in various psychiatric disorders, and recent studies indicated an important role for dopamine D(1) and D(2) receptors and the nucleus accumbens (Acb) in this respect...
  85. ncbi Dissociable contributions of the orbitofrontal and infralimbic cortex to pavlovian autoshaping and discrimination reversal learning: further evidence for the functional heterogeneity of the rodent frontal cortex
    Y Chudasama
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom CB2 3EB
    J Neurosci 23:8771-80. 2003
    ..In contrast, the ILC lesion had no effect on response inhibitory control in either of these settings. The findings are discussed in the context of dissociable executive functions in ventral sectors of the rat prefrontal cortex...
  86. pmc Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans
    Suparna Sanyal
    Departments of Psychiatry, Pharmacology, Institute of Medical Science, University of Toronto and Centre for Addiction and Mental Health, Toronto, Canada
    EMBO J 23:473-82. 2004
    ..The tyrosine hydroxylase-deficient C. elegans mutant (cat-2) also displays these specific behavioral deficits. These observations provide genetic evidence that dopamine signaling modulates behavioral plasticity in C. elegans...
  87. ncbi Primates--a natural heritage of conflict resolution
    F B de Waal
    Living Links, Center for the Advanced Study of Human and Ape Evolution, Yerkes Regional Primate Research Center, and Psychology Department, Emory University, Atlanta, GA 30322, USA
    Science 289:586-90. 2000
    ..It is only when social relationships are valued that one can expect the full complement of natural checks and balances...
  88. ncbi A critical review of fear tests used on cattle, pigs, sheep, poultry and horses
    B Forkman
    Department of Large Animal Sciences, Roy Vet Agricult Univ, 1870 Frederiksberg, Denmark
    Physiol Behav 92:340-74. 2007
    ..e., what aspects can be changed without affecting the validity of the tests. The relative absence of standardized tests hampers the development of applied ethology as a science...
  89. ncbi The mentality of crows: convergent evolution of intelligence in corvids and apes
    Nathan J Emery
    Sub Department of Animal Behaviour, University of Cambridge, CB3 8AA, UK
    Science 306:1903-7. 2004
    ....
  90. ncbi Long-term effects of early life deprivation on brain glia in Fischer rats
    Michail Leventopoulos
    School of Human and Life Sciences, Whitelands College, Roehampton University, London SW15 4JD, UK
    Brain Res 1142:119-26. 2007
    ..This study provides evidence that early life stress leads to long-term changes in the density of astroglia in the brain regions involved in stress responses in the rat...
  91. ncbi Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice
    Fraser Murray
    Merck Sharp and Dohme, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR United Kingdom
    Eur J Pharmacol 583:115-27. 2008
    ..The results presented here demonstrate that moderately elevated corticosterone for a prolonged period is sufficient to induce cellular changes in the hippocampus that are prevented by chronic administration of antidepressants...
  92. ncbi Rodent models of prefrontal cortical function
    Verity J Brown
    School of Psychology, University of St Andrews, St Andrews KY16 9JU, UK
    Trends Neurosci 25:340-3. 2002
    ..Nevertheless, we argue here that studies of the computational functions within the relatively undifferentiated prefrontal cortex of rats can shed light on processing in primate prefrontal cortex...
  93. ncbi The interactions and dissociations of the dorsal hippocampus subregions: how the dentate gyrus, CA3, and CA1 process spatial information
    Naomi J Goodrich-Hunsaker
    Department of Psychology, University of Utah, Salt Lake City 84112, USA
    Behav Neurosci 122:16-26. 2008
    ..Dorsal CA3 and dCA1 then receive these metric representations transmitted from dDG along the trisynaptic loop. The present data add to a growing body of literature suggesting a diversity of function among the hippocampal subregions...
  94. ncbi Microstimulation of the frontal eye field and its effects on covert spatial attention
    Tirin Moore
    Department of Psychology, Princeton University, Princeton, New Jersey 08544 1010, USA
    J Neurophysiol 91:152-62. 2004
    ..These results demonstrate that transient, but potent improvements in the deployment of covert spatial attention can be obtained by microstimulation of FEF sites from which saccadic eye movements are also evoked...
  95. ncbi Drosophila melanogaster, a genetic model system for alcohol research
    Douglas J Guarnieri
    Department of Anatomy, Program in Neuroscience, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Int Rev Neurobiol 54:199-228. 2003
    ....
  96. ncbi Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications
    Robert H Ring
    Depression and Anxiety Disorders, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Psychopharmacology (Berl) 185:218-25. 2006
    ..Notably, evidence from studies in females has revealed an important role for OT in regulating anxiety behavior...
  97. ncbi Social insects: Cuticular hydrocarbons inform task decisions
    Michael J Greene
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Nature 423:32. 2003
  98. ncbi Pleasures of the brain
    Kent C Berridge
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Brain Cogn 52:106-28. 2003
    ..The same subcortical 'liking' network, via connection to brain systems involved in explicit cognitive representations, may also in turn cause conscious experiences of sensory pleasure...
  99. ncbi A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
    G F Koob
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 848:141-52. 1999
    ....
  100. ncbi Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy
    Sarah J L Flatters
    Anaesthesia Research Unit, McIntyre Building, Room 1213, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, Canada H3G 1Y6
    Pain 109:150-61. 2004
    ..These data suggest that T-type calcium channels may play a role in chemotherapy-induced neuropathy and moreover identify ethosuximide as a new potential treatment for chemotherapy-induced pain...
  101. ncbi Maintaining a behaviour polymorphism by frequency-dependent selection on a single gene
    Mark J Fitzpatrick
    Department of Biology, University of Toronto at Mississauga, Mississauga, Ontario L5L 1C6, Canada
    Nature 447:210-2. 2007
    ..Our study represents a clear demonstration of frequency-dependent selection, and we are able to attribute this effect to a single, naturally polymorphic gene known to affect behaviour...

Research Grants75

  1. OLFACTORY FUNCTION IN GENE-TARGETED MICE
    Burton Slotnick; Fiscal Year: 2002
    ..A final report of these studies will incorporate a detailed description of apparatus, methods protocol and files of raw data and summary statistics presented in database and spreadsheet format. ..
  2. Evaluation in Primates of Cocaine Esterase for the Treatment of Cocaine Toxicity
    Mei Chuan Ko; Fiscal Year: 2010
    ..Dose-response functions for each enzyme will be obtained repeatedly and blood samples analyzed for titer development so that tolerance to the effects of CocE can be monitored. ..
  3. Mechanisms of Associative Learning in Aging: Mouse Models
    Diana S Woodruff Pak; Fiscal Year: 2010
    ..This proposal has the potential to expand perspectives and devise treatments to facilitate learning and memory in older adults. ..
  4. Valence Coding and Regulation of Approach-Avoidance in Social and Asocial Species
    James L Goodson; Fiscal Year: 2010
    ..We additionally propose the development of VT RNA interference that will enable us to specifically knock down VT production, thus allowing the functional investigation of specific VT cell groups. ..
  5. Steroid Receptors and Brain Sex Differences
    Anthony P Auger; Fiscal Year: 2010
    ....
  6. Intrathecal Opioid-Induced Pruritus
    Mei Chuan Ko; Fiscal Year: 2003
    ..These studies would provide a systematic understanding of the pharmacology of intrathecal morphine-induced pruritus in primates and establish the basis for identifying potential therapeutically effective antipruritics. ..
  7. Can beta-lactam antibiotics decrease morphine physical dependence?
    SCOTT RAWLS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  8. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
  9. Prenatal ethanol, social behavior, and prefrontal cortex
    Derek Hamilton; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. Mid-Brain Modulation of Social Attachment
    Joseph Curtis; Fiscal Year: 2008
    ..The results of these studies will further our understanding of the brain circuitry involved in social attachment, and thus provide insights into the causes of a variety of human ailments. [unreadable] [unreadable]..
  11. Novel Delta Opioids: Analgesic Effects & Abuse Liability
    SIDNEY NEGUS; Fiscal Year: 2009
    ....
  12. Molecular Basis of D1 and D2 Priming
    Alexia Pollack; Fiscal Year: 2003
    ..Elucidation of this mechanism could lead to treatment strategies aimed to prevent these dyskinesias, which would, in turn, lengthen the time that dopamine replacement therapy is effective to treat patients with PD. ..
  13. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..
  14. Aging and Sites of Action of Cognition-Enhancing Drugs
    DIANA WOODRUFF PAK; Fiscal Year: 2008
    ..These studies will likely support hypotheses about ACh mechanisms in learning and memory and may identify the cerebellum as an additional site of drug action. [unreadable] [unreadable]..
  15. Genetics of Wing and Cell-Size Evolution in Nasonia
    John Werren; Fiscal Year: 2008
    ....
  16. OLFACTORY CODING
    Burton Slotnick; Fiscal Year: 2003
    ..Behavior tasks will use precision olfactometry. Anterograde transport of horseradish peroxidase will be used to assess connections between the olfactory epithelium and olfactory bulb in experimental rats. ..
  17. in vivo characterization of D2/D3 agonists & antagonists
    Gregory Collins; Fiscal Year: 2007
    ..abstract_text> ..
  18. Alcohol disrupts TLR4 signaling in lipid rafts
    Angela Dolganiuc; Fiscal Year: 2008
    ..Investigation of the early steps of LPS signaling may identify strategies for interfering with the effects of LPS and design therapeutic approaches for improving immunity against infections. [unreadable] [unreadable] [unreadable]..
  19. Alcoholism risk and protective factors in Trinidad
    Cindy Ehlers; Fiscal Year: 2006
    ..Study findings can be compared to similar studies being conducted in the US. We believe these studies will allow for the identification of risk and protective factors for alcoholism in these islands. [unreadable] [unreadable]..
  20. Dynamic Models of Reconditioning
    Peter Killeen; Fiscal Year: 2006
    ..By providing statistically powerful tests of competing models of underlying behavioral machinery, we may get closer to understanding how to mitigate such fatal obsessions. ..
  21. Genetic Manipulation of Phasic Dopaminergic Activity
    Jeff Beeler; Fiscal Year: 2007
    ..A computational model formalizing a hypothesized relationship between reinforcement learning and motivation and incorporating both phasic and tonic activity will be developed. ..
  22. Function of Casein Kinase 2 in the Circadian Clock
    Ravi Allada; Fiscal Year: 2007
    ..The discovery of a circadian function of CK2 in plants, animals, and fungi suggests these studies will be relevant to many biological systems, including humans. ..
  23. Regulation of Ethanol Reward by 5HT1B Receptors
    John Neumaier; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  24. NEUROPEPTIDERGIC CONTROL OF MATERNAL BEHAVIOR
    BENJAMIN NEPHEW; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  25. Neurophysiology and Neurochemistry of Decision-Making
    Arwen Long; Fiscal Year: 2006
    ..Therefore, a better understanding of decision-making processes will improve our understanding of these neuropsychological diseases and contribute to the development of better treatments. [unreadable] [unreadable] [unreadable]..
  26. Somatosensory Cortical Influences on Subcortical Processing
    KEVIN ALLOWAY; Fiscal Year: 2007
    ..Aim 4. Support or refute the hypothesis that stimulus-induced neuronal activity in SI barrel cortex and the pons are more strongly correlated than stimulus-induced activity in SI cortex and the neostriatum. ..
  27. Ethanol and mesolimbic GABAergic neurons
    Jiang Hong Ye; Fiscal Year: 2007
    ..Such results will provide valuable information on novel mechanisms underlying the addictive properties of alcohol and a firm scientific foundation for future neurobiological studies. [unreadable] [unreadable] [unreadable]..
  28. Effects of Early Experience
    Carol Carter; Fiscal Year: 2009
    ..Intergenerational effects of these experiences will be examined as well. ..
  29. ELECTROPHYSIOLOGY & PHARMACOLOGY OF SLEEP-WAKEFULNESS
    Mahesh Thakkar; Fiscal Year: 2004
    ..Preliminary data suggest a strong suppressive effect of microdialysis-applied 8-OH-DPAT on state-related discharge activity of the dorsal raphe nucleus, and we will also investigate the effects of 5HT1A antagonists. ..
  30. Early Life Infection, Neuroinflammation, and Memory
    Staci D Bilbo; Fiscal Year: 2010
    ....
  31. Circadian organization in the aged rodent
    Alec Davidson; Fiscal Year: 2004
    ....
  32. Pathophysiology of glia following traumatic brain injury
    RAIMONDO D AMBROSIO; Fiscal Year: 2005
    ..Investigations on these post-traumatic changes will allow a more rational treatment to TBI. ..
  33. RSA Lecture Series
    Jennifer Thomas; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. RESULT OF MODALITY CONVERGENCE IN THE BRAIN
    Barry Stein; Fiscal Year: 2005
    ....
  35. Pharmacogenetics in Tourette Syndrom
    Harvey Singer; Fiscal Year: 2004
    ..The identification of genetic polymorphisms that are associated with clinical disease or treatment success, has obvious benefits. ..
  36. Behavior/Drug Interactions in Striatal gene Regulation
    Heinz Steiner; Fiscal Year: 2003
    ..These studies should provide new insights into how the behavior executed during the drug action can influence drug-induced neuroplasticity in the striaturn. ..
  37. Centrifugal Modulation of Visual Sensitivity
    Lei Li; Fiscal Year: 2010
    ..The results from the proposed research will shed light on the mechanisms of centrifugal modulation of visual sensitivity. ..
  38. PERIPHERAL SOMATOSTATIN CONTROLS INFLAMMATORY PAIN
    Susan Carlton; Fiscal Year: 2004
    ..Peripheral SST receptors offer novel targets for nociceptor modulation and are likely targets for further development of non-opioid therapies to aid in reducing the pain and long-term deleterious changes that can accompany inflammation. ..
  39. Errors and Expectancies in OFC and VTA and their Roles in Associative Learning
    GEOFFREY M SCHOENBAUM; Fiscal Year: 2010
    ..This proposal will test this hypothesis, using inactivation and single-unit recording to ask how OFC is involved learning and in the calculation of prediction errors in dopaminergic VTA neurons during Pavlovian blocking. ..
  40. Antipsychotic Drugs and Maternal Behavior: A Preclinical Investigation
    Ming Li; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  41. Understanding the Mechanisms of Neuropathogenesis
    MICHAEL JOHN PALLADINO; Fiscal Year: 2010
    ..Together these specific experiments will elucidate the mechanisms of neuropathogenesis in ATPalpha mutants and lead to a better understanding of age-related neurodegeneration and senescence. ..
  42. Genetic approach to the assembly of parallel circuits in the visual system
    Herwig Baier; Fiscal Year: 2010
    ..This study proposes to identify the molecules that are important for this process during development and growth of the vertebrate organism, thus. ..
  43. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  44. A Novel Animal Model of Relevance to Schizophrenia
    David Feifel; Fiscal Year: 2009
    ..The successful development of this animal model could significantly enhance the understanding of the underlying causes of schizophrenia-associated abnormalities and improve drug discovery. ..
  45. CNS Stress Pathways and the Development of Acute HAAF
    Dianne Lattemann; Fiscal Year: 2003
    ..abstract_text> ..
  46. Somatosensory Cortical Influences on Subcortical Processing
    KEVIN DOUGLAS ALLOWAY; Fiscal Year: 2010
    ....
  47. Does Nasal Stimulation Activate Presympathetic Neurons?
    Paul McCulloch; Fiscal Year: 2005
    ..As such, this research has implications for understanding the etiology of neurogenic hypertension. ..
  48. Intrinsic Anatomy of the Circadian Rhythm System
    LAWRENCE MORIN; Fiscal Year: 2005
    ..The results will provide the anatomical framework necessary for interpretation of future physiological and molecular experiments. ..
  49. Endogenous Agmatine in Glutamatergic Pain Processing
    CAROLYN FAIRBANKS; Fiscal Year: 2005
    ..Elucidation of the role of the endogenous agmatine during hyperalgesia and allodynia may lead to the development of a novel class of analgesic drugs or the identification of therapeutic targets. ..
  50. ALCOHOL APPETITE--A NUTRIENT CONDITIONING ANALYSIS
    Karen Ackroff; Fiscal Year: 2001
    ..It will advance our basic knowledge of the psychobiology of alcohol appetite and may provide practical benefits for controlling alcohol consumption in humans. ..
  51. Ethological Categorization and the Prefrontal Cortex
    YALE COHEN; Fiscal Year: 2006
    ..provided by applicant): Communication is one of the fundamental components of both human and non-human animal behavior. While the benefits and importance of language in human evolution are obvious, other non-human communication ..
  52. ELEMENTARY SCHOOL NEUROSCIENCE LITERACY
    Gary Duncan; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  53. Hearing in Belgian Waterslager Canaries
    AMANDA LAUER; Fiscal Year: 2004
    ..Thus, the proposed experiments will increase our understanding of the functional consequences of hearing impairment in these birds, and of hearing impairment in general. ..
  54. Mechanisms of Inhibitory Glycine Receptor Modulation
    KWEE THIO; Fiscal Year: 2006
    ..abstract_text> ..
  55. GNE 2007: Global NeuroEngineering 2007
    Miguel Nicolelis; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. Developmental Differences in Brain Androgen Synthesis
    Sarah London; Fiscal Year: 2004
    ..They will also indicate potential regulatory mechanisms for androgen synthesis in other species, including humans. ..
  57. Behavioral Economics in Closed Economies
    GREGORY MADDEN; Fiscal Year: 2003
    ..Correct predictions will support the behavioral economic account of relative reinforcer efficacy. Experiment 2 will assess the same predictions using drug (alcohol self-administration) and non-drug reinforcers. ..
  58. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 2003
    ....
  59. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  60. The Role of Areas V1 and V2 in Target Selection
    Peter Schiller; Fiscal Year: 2008
    ..abstract_text> ..
  61. CHARACTERIZING SPECIALIZED CHEMOSENSORY NEURONS
    STEVEN MUNGER; Fiscal Year: 2002
    ..In addition, GC-D transgenic mice will be used to examine the ability of neonates to attach to nipples and suckle. ..
  62. Chemosensory receptors and the basis of specificity
    STEVEN MUNGER; Fiscal Year: 2009
    ..abstract_text> ..
  63. NEURAL CONTROL OF VISUALLY GUIDED EYE MOVEMENTS
    Peter Schiller; Fiscal Year: 2007
    ..abstract_text> ..
  64. "Post-partum steroid withdrawal-induced depression"
    REBECCA CRAFT; Fiscal Year: 2006
    ..Findings from the proposed model will enhance our understanding of the etiology of PPD and possibly lead to improved treatment options. ..
  65. Evolutionary Graph Theory and Its Applications
    Martin Nowak; Fiscal Year: 2009
    ..The results promise a new structuralevolutionary framework for understanding processes that are of vital importance to medicine. ..
  66. IBANGS Annual Meeting support
    John Crabbe; Fiscal Year: 2005
    ..This young society represents an opportunity to attract a core group of young investigators to alcohol research during their formative years. ..
  67. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  68. Algorithm for drug discovery
    GREGORY ELMER; Fiscal Year: 2007
    ..Second, it will establish a core database for data mining and provide a template for use in screening novel compounds with potential clinical efficacy. [unreadable] [unreadable] [unreadable]..
  69. ADOLESCENT MARIJUANA USE IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2008
    ..abstract_text> ..
  70. Function of the Novel Ion Channel narrow abdomen in Daily Rhythms
    Ravi Allada; Fiscal Year: 2008
    ..Given the conservation of clocks and NA, this proposal should illuminate human daily rhythms and their contribution to disease. ..
  71. MOLECULAR MECHANISMS OF CONDITIONED TASTE AVERSION
    THOMAS HOUPT; Fiscal Year: 2004
    ..These experiments will contribute to an understanding of the neural pathways and molecular mechanisms underlying changes in food preferences that occur in eating disorders such as obesity and anorexia nervosa. ..
  72. Eleventh Meeting of the Society for Research on Biological Rhythms
    Ravi Allada; Fiscal Year: 2008
    ..The research presented at the 11th meeting of the Society for Research on Biological Rhythms investigates these links, and could ultimately lead to better diagnostics and therapeutics. [unreadable] [unreadable] [unreadable]..
  73. Microarray analysis of morphine's behavioral effects
    GREGORY ELMER; Fiscal Year: 2007
    ..abstract_text> ..
  74. Trigeminal Autonomic Interactions
    Paul McCulloch; Fiscal Year: 2002
    ..Having a better understanding of brainstem cardiorespiratory integration might provide a neurological basis for the etiology of SIDS. ..
  75. RISK FACTORS FOR ALCOHOLISM IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2006
    ..The identification of such variables may potentially be useful in the development of specific prevention and treatment programs for this population as well as other Native American tribes. ..