circadian rhythm

Summary

Summary: The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, feeding, etc. This rhythm seems to be set by a 'biological clock' which seems to be set by recurring daylight and darkness.

Top Publications

  1. ncbi Phototransduction by retinal ganglion cells that set the circadian clock
    David M Berson
    Department of Neuroscience, Brown University, Providence, RI, 02912 USA
    Science 295:1070-3. 2002
  2. ncbi Coordination of circadian timing in mammals
    Steven M Reppert
    Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 418:935-41. 2002
  3. pmc PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
    Seung Hee Yoo
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 101:5339-46. 2004
  4. pmc Central and peripheral circadian clocks in mammals
    Jennifer A Mohawk
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    Annu Rev Neurosci 35:445-62. 2012
  5. ncbi Coordinated transcription of key pathways in the mouse by the circadian clock
    Satchidananda Panda
    The Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Cell 109:307-20. 2002
  6. pmc The genetics of mammalian circadian order and disorder: implications for physiology and disease
    Joseph S Takahashi
    Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois 60208 3520, USA
    Nat Rev Genet 9:764-75. 2008
  7. pmc Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
    Han Cho
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 485:123-7. 2012
  8. ncbi Circadian topology of metabolism
    Joseph Bass
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 491:348-56. 2012
  9. ncbi The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator
    Nicolas Preitner
    Department of Molecular Biology, Sciences II, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 4, Geneva, Switzerland
    Cell 110:251-60. 2002
  10. pmc Temperature as a universal resetting cue for mammalian circadian oscillators
    Ethan D Buhr
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208 3520, USA
    Science 330:379-85. 2010

Detail Information

Publications351 found, 100 shown here

  1. ncbi Phototransduction by retinal ganglion cells that set the circadian clock
    David M Berson
    Department of Neuroscience, Brown University, Providence, RI, 02912 USA
    Science 295:1070-3. 2002
    ..The sensitivity, spectral tuning, and slow kinetics of this light response matched those of the photic entrainment mechanism, suggesting that these ganglion cells may be the primary photoreceptors for this system...
  2. ncbi Coordination of circadian timing in mammals
    Steven M Reppert
    Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 418:935-41. 2002
    ..However, these independent rhythms are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world...
  3. pmc PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
    Seung Hee Yoo
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 101:5339-46. 2004
    ..These results demonstrate that peripheral tissues express self-sustained, rather than damped, circadian oscillations and suggest the existence of organ-specific synchronizers of circadian rhythms at the cell and tissue level...
  4. pmc Central and peripheral circadian clocks in mammals
    Jennifer A Mohawk
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    Annu Rev Neurosci 35:445-62. 2012
    ..Thus, an emerging view for the adaptive significance of circadian clocks is their fundamental role in orchestrating metabolism...
  5. ncbi Coordinated transcription of key pathways in the mouse by the circadian clock
    Satchidananda Panda
    The Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Cell 109:307-20. 2002
    ..Importantly, rate-limiting steps in these various pathways were key sites of circadian control, highlighting the fundamental role that circadian clocks play in cellular and organismal physiology...
  6. pmc The genetics of mammalian circadian order and disorder: implications for physiology and disease
    Joseph S Takahashi
    Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois 60208 3520, USA
    Nat Rev Genet 9:764-75. 2008
    ..Together, these studies set the scene for applying our knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders...
  7. pmc Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
    Han Cho
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 485:123-7. 2012
    ..data now unite REV-ERB-α and REV-ERB-β with PER, CRY and other components of the principal feedback loop that drives circadian expression and indicate a more integral mechanism for the coordination of circadian rhythm and metabolism.
  8. ncbi Circadian topology of metabolism
    Joseph Bass
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 491:348-56. 2012
    ..Biological clocks capture the imagination because of their tie to geophysical time, and tools are now in hand to analyse their function in health and disease at the cellular and molecular level...
  9. ncbi The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator
    Nicolas Preitner
    Department of Molecular Biology, Sciences II, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 4, Geneva, Switzerland
    Cell 110:251-60. 2002
    ..While REV-ERBalpha influences the period length and affects the phase-shifting properties of the clock, it is not required for circadian rhythm generation.
  10. pmc Temperature as a universal resetting cue for mammalian circadian oscillators
    Ethan D Buhr
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208 3520, USA
    Science 330:379-85. 2010
    ..These results suggest that the evolutionarily ancient temperature resetting response can be used in homeothermic animals to enhance internal circadian synchronization...
  11. ncbi The mammalian circadian timing system: organization and coordination of central and peripheral clocks
    Charna Dibner
    Division of Endocrinology, Diabetes and Nutrition, Geneva University Hospital, Geneva 14, Switzerland
    Annu Rev Physiol 72:517-49. 2010
    ..Thus, some of the SCN output pathways serve as input pathways for peripheral tissues. Here we discuss knowledge acquired during the past few years on the complex structure and function of the mammalian circadian timing system...
  12. pmc Peroxiredoxins are conserved markers of circadian rhythms
    Rachel S Edgar
    Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nature 485:459-64. 2012
    ..Our results suggest an intimate co-evolution of cellular timekeeping with redox homeostatic mechanisms after the Great Oxidation Event ∼2.5 billion years ago...
  13. pmc Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity
    S Hattar
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Science 295:1065-70. 2002
    ..Hence, melanopsin is most likely the visual pigment of phototransducing RGCs that set the circadian clock and initiate other non-image-forming visual functions...
  14. pmc Mop3 is an essential component of the master circadian pacemaker in mammals
    M K Bunger
    The McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, WI 53706, USA
    Cell 103:1009-17. 2000
    ..These results provide genetic evidence that MOP3 is the bona fide heterodimeric partner of mCLOCK. Furthermore, these data demonstrate that MOP3 is a nonredundant and essential component of the circadian pacemaker in mammals...
  15. ncbi SIRT1 regulates circadian clock gene expression through PER2 deacetylation
    Gad Asher
    Department of Molecular Biology, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Cell 134:317-28. 2008
    ..Given the NAD(+) dependence of SIRT1 deacetylase activity, it is likely that SIRT1 connects cellular metabolism to the circadian core clockwork circuitry...
  16. pmc Obesity and metabolic syndrome in circadian Clock mutant mice
    Fred W Turek
    Department of Neurology, Northwestern University, Evanston, IL 60208, USA
    Science 308:1043-5. 2005
    ..These results suggest that the circadian clock gene network plays an important role in mammalian energy balance...
  17. pmc Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists
    Laura A Solt
    Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA
    Nature 485:62-8. 2012
    ..These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
  18. ncbi System-level identification of transcriptional circuits underlying mammalian circadian clocks
    Hiroki R Ueda
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Nat Genet 37:187-92. 2005
    ..Our analysis further suggests that regulation of E/E' boxes is a topological vulnerability in mammalian circadian clocks, a concept that has been functionally verified using in vitro phenotype assay systems...
  19. pmc Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
    Biliana Marcheva
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 466:627-31. 2010
    ..These results demonstrate a role for the beta-cell clock in coordinating insulin secretion with the sleep-wake cycle, and reveal that ablation of the pancreatic clock can trigger the onset of diabetes mellitus...
  20. ncbi Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage
    Antony N Dodd
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK
    Science 309:630-3. 2005
    ..This explains why plants gain advantage from circadian control...
  21. pmc Sleep state switching
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuron 68:1023-42. 2010
    ..We also review how homeostatic, circadian, and allostatic drives help regulate sleep state switching and discuss how breakdown of the switching mechanism may contribute to sleep disorders such as narcolepsy...
  22. ncbi Hypothalamic regulation of sleep and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Nature 437:1257-63. 2005
    ..These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake-sleep cycles into the optimal pattern for survival...
  23. pmc Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver
    Guillaume Rey
    School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    PLoS Biol 9:e1000595. 2011
    ..Together, our analysis of a dynamic protein-DNA interactome uncovered how genes of the core circadian oscillator crosstalk and drive phase-specific circadian output programs in a complex tissue...
  24. pmc The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
    Yasukazu Nakahata
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Cell 134:329-40. 2008
    ..We propose that SIRT1 functions as an enzymatic rheostat of circadian function, transducing signals originated by cellular metabolites to the circadian clock...
  25. ncbi Posttranslational mechanisms regulate the mammalian circadian clock
    C Lee
    Department of Neurobiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Cell 107:855-67. 2001
    ..We also provide in vivo evidence that casein kinase I delta is a second clock relevant kinase...
  26. pmc Harmonics of circadian gene transcription in mammals
    Michael E Hughes
    Department of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 5:e1000442. 2009
    ....
  27. pmc A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism
    Dan Feng
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 331:1315-9. 2011
    ..We show that histone deacetylase 3 (HDAC3) recruitment to the genome displays a circadian rhythm in mouse liver...
  28. pmc Genetics of circadian rhythms in Mammalian model organisms
    Phillip L Lowrey
    Department of Biology, Rider University, Lawrenceville, New Jersey, USA
    Adv Genet 74:175-230. 2011
    ....
  29. pmc Design principles of biochemical oscillators
    Bela Novak
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nat Rev Mol Cell Biol 9:981-91. 2008
    ..Positive feedback is one mechanism to delay the negative-feedback signal. Biological oscillators can be classified according to the topology of the positive- and negative-feedback loops in the underlying regulatory mechanism...
  30. pmc The circadian clock and pathology of the ageing brain
    Anna A Kondratova
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Nat Rev Neurosci 13:325-35. 2012
    ..Potential molecular mechanisms underlying this link include the circadian control of physiological processes such as brain metabolism, reactive oxygen species homeostasis, hormone secretion, autophagy and stem cell proliferation...
  31. ncbi Crosstalk between components of circadian and metabolic cycles in mammals
    Gad Asher
    Department of Molecular Biology and National Centre of Competence in Research Frontiers in Genetics, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Cell Metab 13:125-37. 2011
    ..The intertwining between these acute regulators and circadian clock components is so tight that the discrimination between metabolic and circadian oscillations may be somewhat arbitrary...
  32. pmc Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
    F Damiola
    , Sciences II, , CH-1211 Geneva, Switzerland
    Genes Dev 14:2950-61. 2000
    ..Food-induced phase resetting proceeds faster in liver than in kidney, heart, or pancreas, but after 1 wk of daytime feeding, the phases of circadian gene expression are similar in all examined peripheral tissues...
  33. ncbi Neurobiology of food anticipatory circadian rhythms
    Ralph E Mistlberger
    Department of Psychology, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada
    Physiol Behav 104:535-45. 2011
    ..Given the dominant role of food as an entraining stimulus for metabolic rhythms, the timing of daily food intake and the fidelity of food entrainment mechanisms are likely to have clinical relevance...
  34. ncbi Rest in Drosophila is a sleep-like state
    J C Hendricks
    Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Neuron 25:129-38. 2000
    ..Finally, normal homeostatic regulation depends on the timeless but not the period central clock gene. Understanding the molecular features of Drosophila rest should shed new light on the mechanisms and function of sleep...
  35. pmc The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops
    Alexandra Pokhilko
    School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Mol Syst Biol 8:574. 2012
    ..As well as matching timeseries and phase-response data, the model provides a new conceptual framework for the plant clock that includes a three-component repressilator circuit in its complex structure...
  36. ncbi Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells
    Emi Nagoshi
    Department of Molecular Biology and NCCR Frontiers in Genetics, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Cell 119:693-705. 2004
    ..Specifically, the circadian oscillator gates cytokinesis to defined time windows, and mitosis elicits phase shifts in circadian cycles...
  37. pmc Adverse metabolic and cardiovascular consequences of circadian misalignment
    Frank A J L Scheer
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:4453-8. 2009
    ..These findings demonstrate the adverse cardiometabolic implications of circadian misalignment, as occurs acutely with jet lag and chronically with shift work...
  38. ncbi Post-translational modifications regulate the ticking of the circadian clock
    Monica Gallego
    Center for Children, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA
    Nat Rev Mol Cell Biol 8:139-48. 2007
    ..Mutations in kinases and phosphatases in hamsters, flies, fungi and humans highlight how our timepieces are regulated and provide clues as to how we might be able to manipulate them...
  39. ncbi Clocks not winding down: unravelling circadian networks
    Eric E Zhang
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive 0130, La Jolla, California 92093 0130, USA
    Nat Rev Mol Cell Biol 11:764-76. 2010
    ....
  40. pmc The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth
    Dmitri A Nusinow
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego 9500 Gilman Drive, La Jolla, California 92093 0130, USA
    Nature 475:398-402. 2011
    ..Therefore, the evening complex underlies the molecular basis for circadian gating of hypocotyl growth in the early evening...
  41. ncbi Resetting of circadian time in peripheral tissues by glucocorticoid signaling
    A Balsalobre
    , Sciences II, , 30 Quai Ernest Ansermet, , Switzerland
    Science 289:2344-7. 2000
    ..In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throughout the day...
  42. ncbi Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
    Yasukazu Nakahata
    Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Science 324:654-7. 2009
    ..Our findings in mouse embryo fibroblasts reveal an interlocked transcriptional-enzymatic feedback loop that governs the molecular interplay between cellular metabolism and circadian rhythms...
  43. ncbi Entrainment of the circadian clock in the liver by feeding
    K A Stokkan
    National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, P O Box 400328, Charlottesville, VA 22904 4328, USA
    Science 291:490-3. 2001
    ..They also raise the possibility that peripheral circadian oscillators like those in the liver may be coupled to the SCN primarily through rhythmic behavior, such as feeding...
  44. pmc Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision
    Jennifer L Ecker
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuron 67:49-60. 2010
    ..Thus, nonclassical retinal photoreception occurs within diverse cell types and influences circuits and functions encompassing luminance as well as spatial information...
  45. pmc Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
    Kathryn Moynihan Ramsey
    Department of Medicine, Northwestern University Feinberg School of Medicine, 2200 Campus Drive, Evanston, IL 60208 3500, USA
    Science 324:651-4. 2009
    ..In turn, the circadian transcription factor CLOCK binds to and up-regulates Nampt, thus completing a feedback loop involving NAMPT/NAD+ and SIRT1/CLOCK:BMAL1...
  46. ncbi Extensive and divergent circadian gene expression in liver and heart
    Kai Florian Storch
    Department of Neurobiology, Harvard Medical School, Northeastern University, Boston, Massachusetts 02115, USA
    Nature 417:78-83. 2002
    ..A core set of 37 genes with similar circadian regulation in both tissues includes candidates for new clock genes and output genes, and it contains genes responsive to circulating factors with circadian or diurnal rhythms...
  47. ncbi Control mechanism of the circadian clock for timing of cell division in vivo
    Takuya Matsuo
    Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    Science 302:255-9. 2003
    ..In contrast, the circadian clockwork oscillated independently of the cell cycle in single cells. Thus, the intracellular circadian clockwork can control the cell-division cycle directly and unidirectionally in proliferating cells...
  48. pmc JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets
    Michael E Hughes
    Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA
    J Biol Rhythms 25:372-80. 2010
    ..These data suggest that JTK_CYCLE is an ideal tool for identifying and characterizing oscillations in genome-scale data sets...
  49. pmc Molecular genetic analysis of circadian timekeeping in Drosophila
    Paul E Hardin
    Department of Biology and Center for Biological Clocks Research, Texas A and MUniversity, College Station, USA
    Adv Genet 74:141-73. 2011
    ....
  50. ncbi A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila
    S C Renn
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Cell 99:791-802. 1999
    ..These results confirm the assignment of LNv neurons as the principal circadian pacemakers controlling daily locomotion in Drosophila. They also implicate PDF as the principal circadian transmitter...
  51. pmc Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function
    Anne Bugge
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 26:657-67. 2012
    The nuclear receptor Rev-erbα regulates circadian rhythm and metabolism, but its effects are modest and it has been considered to be a secondary regulator of the cell-autonomous clock...
  52. pmc Physiological significance of a peripheral tissue circadian clock
    Katja A Lamia
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:15172-7. 2008
    ..Our findings suggest that the liver clock contributes to homeostasis by driving a daily rhythm of hepatic glucose export that counterbalances the daily cycle of glucose ingestion resulting from the fasting-feeding cycle...
  53. ncbi Physiology of circadian entrainment
    Diego A Golombek
    Laboratory of Chronobiology, Department of Science and Technology, University of Quilmes Consejo Nacional de Investigaciones Científicas y Tecnológicas CONICET, Quilmes, Argentina
    Physiol Rev 90:1063-102. 2010
    ..Finally, we describe and analyze clock gene expression and its importance in entrainment mechanisms, as well as circadian disorders or retinal diseases related to entrainment deficits, including experimental and clinical treatments...
  54. ncbi The pseudo-response regulator Ppd-H1 provides adaptation to photoperiod in barley
    Adrian Turner
    Crop Genetics Department, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Science 310:1031-4. 2005
    ....
  55. ncbi Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
    G T van der Horst
    MGC, Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Nature 398:627-30. 1999
    ..This suggests that, in addition to a possible photoreceptor and antagonistic clock-adjusting function, both proteins are essential for the maintenance of circadian rhythmicity...
  56. pmc PSEUDO-RESPONSE REGULATORS 9, 7, and 5 are transcriptional repressors in the Arabidopsis circadian clock
    Norihito Nakamichi
    RIKEN Plant Science Center, Plant Productivity Systems Research Group, Tsurumi, Yokohama 230 0045, Japan
    Plant Cell 22:594-605. 2010
    ..These results suggest that the repressor activities of PRR9, PRR7, and PRR5 on the CCA1 and LHY promoter regions constitute the molecular mechanism that accounts for the role of these proteins in the feedback loop of the circadian clock...
  57. pmc Temporal orchestration of circadian autophagy rhythm by C/EBPβ
    Di Ma
    Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, 48109, USA
    EMBO J 30:4642-51. 2011
    ..Here, we show that autophagy exhibits robust circadian rhythm in mouse liver, which is accompanied by cyclic induction of genes involved in various steps of autophagy...
  58. ncbi A clockwork web: circadian timing in brain and periphery, in health and disease
    Michael H Hastings
    Division of Neurobiology, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Rev Neurosci 4:649-61. 2003
  59. pmc microRNA modulation of circadian-clock period and entrainment
    Hai Ying M Cheng
    Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
    Neuron 54:813-29. 2007
    ..Collectively, these data reveal miRNAs as clock- and light-regulated genes and provide a mechanistic examination of their roles as effectors of pacemaker activity and entrainment...
  60. ncbi The late elongated hypocotyl mutation of Arabidopsis disrupts circadian rhythms and the photoperiodic control of flowering
    R Schaffer
    John Innes Centre, Norwich, United Kingdom
    Cell 93:1219-29. 1998
    ..Thus, constant expression of LHY disrupts several distinct circadian rhythms in Arabidopsis, and LHY may be closely associated with the central oscillator of the circadian clock...
  61. pmc An expanding universe of circadian networks in higher plants
    Jose L Pruneda-Paz
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093, USA
    Trends Plant Sci 15:259-65. 2010
    ..Future studies will determine the molecular mechanisms involved in these complex regulatory loops...
  62. pmc Intercellular coupling confers robustness against mutations in the SCN circadian clock network
    Andrew C Liu
    Department of Biochemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 129:605-16. 2007
    ....
  63. pmc Circadian rhythms persist without transcription in a eukaryote
    John S O'Neill
    Centre for Systems Biology at Edinburgh, C H Waddington Building, Mayfield Road, Edinburgh EH9 3JD, UK
    Nature 469:554-8. 2011
    ..It is plausible that the oldest oscillator components are non-transcriptional in nature, as in cyanobacteria, and are conserved across kingdoms...
  64. pmc Altered circadian rhythms regulate growth vigour in hybrids and allopolyploids
    Zhongfu Ni
    Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, One University Station, A 4800, Austin, Texas 78712, USA
    Nature 457:327-31. 2009
    ..The causal effects of CCA1 on output traits suggest that hybrids and allopolyploids gain advantages from the control of circadian-mediated physiological and metabolic pathways, leading to growth vigour and increased biomass...
  65. pmc Suprachiasmatic nucleus: cell autonomy and network properties
    David K Welsh
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Annu Rev Physiol 72:551-77. 2010
    ..Thus, even though individual SCN neurons can be cell-autonomous circadian oscillators, neuronal network properties are integral to normal function of the SCN...
  66. ncbi High-fat diet disrupts behavioral and molecular circadian rhythms in mice
    Akira Kohsaka
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Cell Metab 6:414-21. 2007
    ..These results indicate that consumption of a high-calorie diet alters the function of the mammalian circadian clock...
  67. ncbi Delay in feedback repression by cryptochrome 1 is required for circadian clock function
    Maki Ukai-Tadenuma
    Laboratory for Systems Biology, RIKEN Center for Developmental Biology, Chuo Ku, Kobe, Hyogo, Japan
    Cell 144:268-81. 2011
    ..Taken together, our data suggest that phase delay in Cry1 transcription is required for mammalian clock function...
  68. pmc Circadian rhythms and metabolic syndrome: from experimental genetics to human disease
    Eleonore Maury
    Northwestern University, Pancoe ENH Pavilion Room 4405, 2200 Campus Dr, Evanston, IL 60208, USA
    Circ Res 106:447-62. 2010
    ..Consideration of the cell and molecular links between disorders of circadian rhythms and sleep with metabolic syndrome has begun to open new opportunities for mechanism-based therapeutics...
  69. ncbi CONSTANS mediates between the circadian clock and the control of flowering in Arabidopsis
    P Suárez-López
    John Innes Centre, Norwich Research Park, Colney Lane, Norwich NR4 7UH, UK
    Nature 410:1116-20. 2001
    ..In addition, the late flowering phenotype of such mutants is corrected by overexpressing CO. Thus, CO acts between the circadian clock and the control of flowering, suggesting mechanisms by which day length regulates flowering time...
  70. ncbi A functional genomics strategy reveals Rora as a component of the mammalian circadian clock
    Trey K Sato
    Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, California 92121, USA
    Neuron 43:527-37. 2004
    ..These results suggest that opposing activities of the orphan nuclear receptors Rora and Rev-erb alpha, which represses Bmal1 expression, are important in the maintenance of circadian clock function...
  71. pmc Integration of microRNA miR-122 in hepatic circadian gene expression
    David Gatfield
    Department of Molecular Biology, Sciences III, University of Geneva, Geneva, Switzerland
    Genes Dev 23:1313-26. 2009
    ....
  72. ncbi A serum shock induces circadian gene expression in mammalian tissue culture cells
    A Balsalobre
    Departement de Biologie Moleculaire, Sciences II, Universite de Geneve, Switzerland
    Cell 93:929-37. 1998
    ..The serum shock of rat-1 fibroblasts also results in a transient stimulation of c-fos and rper expression and thus mimics light-induced immediate-early gene expression in the suprachiasmatic nucleus...
  73. pmc CONSTANS and the CCAAT box binding complex share a functionally important domain and interact to regulate flowering of Arabidopsis
    Stephan Wenkel
    Max Planck Institute for Plant Breeding Research, D 50829 Cologne, Germany
    Plant Cell 18:2971-84. 2006
    ..During plant evolution, the number of genes encoding HAP proteins was greatly amplified, and these proteins may have acquired novel functions, such as mediating the effect of CCT domain proteins on gene expression...
  74. ncbi Correlates of sleep and waking in Drosophila melanogaster
    P J Shaw
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 287:1834-7. 2000
    ..These results implicate the catabolism of monoamines in the regulation of sleep and waking in the fly and suggest that Drosophila may serve as a model system for the genetic dissection of sleep...
  75. pmc System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock
    Benoît Kornmann
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    PLoS Biol 5:e34. 2007
    ..The finding that rhythmic mPer2 expression can be driven by both systemic cues and local oscillators suggests a plausible mechanism for the phase entrainment of subsidiary clocks in peripheral organs...
  76. pmc The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines
    Julie E Gibbs
    Faculty of Life Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 109:582-7. 2012
    ..REV-ERBα may therefore represent a unique therapeutic target in human inflammatory disease...
  77. pmc AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
    Katja A Lamia
    Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Science 326:437-40. 2009
    ..Thus, phosphorylation by AMPK enables cryptochrome to transduce nutrient signals to circadian clocks in mammalian peripheral organs...
  78. pmc The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1
    Hyeong Min Lee
    Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA
    Proc Natl Acad Sci U S A 108:16451-6. 2011
    ..and genetic studies have shown that changes in PER phosphorylation kinetics are associated with changes in circadian rhythm period and phase, which can lead to sleep disorders such as Familial Advanced Sleep Phase Syndrome in humans...
  79. pmc Transcription factors in light and circadian clock signaling networks revealed by genomewide mapping of direct targets for neurospora white collar complex
    Kristina M Smith
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, 97331 7305, USA
    Eukaryot Cell 9:1549-56. 2010
    ..Our findings provide links between the key circadian activator and effectors in downstream regulatory pathways...
  80. ncbi Night eating syndrome and nocturnal snacking: association with obesity, binge eating and psychological distress
    S L Colles
    Centre for Obesity Research and Education, The Alfred Hospital, Monash University, Melbourne, Victoria, Australia
    Int J Obes (Lond) 31:1722-30. 2007
    ..This study aimed to investigate the clinical significance of NES and nocturnal snacking by exploring the relationship between NES and (1) obesity, (2) binge eating disorder (BED) and (3) psychological distress...
  81. pmc Analysis of gene regulatory networks in the mammalian circadian rhythm
    Jun Yan
    CAS MPG Partner Institute for Computational Biology, Shanghai Institutes of Biological Sciences, Shanghai, China
    PLoS Comput Biol 4:e1000193. 2008
    b>Circadian rhythm is fundamental in regulating a wide range of cellular, metabolic, physiological, and behavioral activities in mammals...
  82. pmc Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms
    D J Dijk
    Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 516:611-27. 1999
    ....
  83. ncbi Cumulative sleepiness, mood disturbance, and psychomotor vigilance performance decrements during a week of sleep restricted to 4-5 hours per night
    D F Dinges
    Department of Psychiatry, University of Pennyslvania School of Medicine, Philadelphia 19104-6021, USA
    Sleep 20:267-77. 1997
    ..These findings suggest that cumulative nocturnal sleep debt had a dynamic and escalating analog in cumulative daytime sleepiness and that asymptotic or steady-state sleepiness was not achieved in response to sleep restriction...
  84. pmc REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis
    Gwendal Le Martelot
    Department of Molecular Biology and NCCR Frontiers in Genetics, Sciences III, University of Geneva, Geneva, Switzerland
    PLoS Biol 7:e1000181. 2009
    ..In conclusion, our study suggests that rhythmic cholesterol and bile acid metabolism is not just driven by alternating feeding-fasting cycles, but also by REV-ERBalpha, a component of the circadian clockwork circuitry...
  85. pmc Circadian genes, rhythms and the biology of mood disorders
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Pharmacol Ther 114:222-32. 2007
    ..In this review, the evidence linking circadian rhythms and mood disorders, and what is known about the underlying biology of this association, is presented...
  86. ncbi A review of the multiple actions of melatonin on the immune system
    Antonio Carrillo-Vico
    Department of Medical Biochemistry and Molecular Biology, The University of Seville School of Medicine and Virgen Macarena Hospital, Seville, Spain
    Endocrine 27:189-200. 2005
    ..The review focuses on melatonin's actions in several immune pathologies including infection, inflammation, and autoimmunity together with the relation between melatonin, immunity, and cancer...
  87. ncbi Constitutive expression of the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) gene disrupts circadian rhythms and suppresses its own expression
    Z Y Wang
    Department of Molecular, Cell, and Developmental Biology, UCLA, Los Angeles, California 90095 1606, USA
    Cell 93:1207-17. 1998
    ..Expression of the CCA1 gene is transiently induced by phytochrome and oscillates with a circadian rhythm. Constitutive expression of CCA1 protein in transgenic plants abolished the circadian rhythm of several genes ..
  88. pmc The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors
    Isabelle Schmutz
    Department of Medicine, Unit of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
    Genes Dev 24:345-57. 2010
    ..The concept that PER2 may propagate clock information to metabolic pathways via nuclear receptors adds an important facet to the clock-dependent regulation of biological networks...
  89. pmc Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior
    M H Vitaterna
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208
    Science 264:719-25. 1994
    ..The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals...
  90. ncbi PERIOD3, circadian phenotypes, and sleep homeostasis
    Derk Jan Dijk
    Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XP, UK
    Sleep Med Rev 14:151-60. 2010
    ..These findings highlight the interrelatedness of circadian rhythmicity and sleep homeostasis...
  91. ncbi Synchronization of cellular clocks in the suprachiasmatic nucleus
    Shun Yamaguchi
    Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Science 302:1408-12. 2003
    ..Na+-dependent action potentials contributed to establishing cellular synchrony and maintaining spontaneous oscillation across the SCN...
  92. ncbi Nuclear receptor expression links the circadian clock to metabolism
    Xiaoyong Yang
    Gene Expression Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 126:801-10. 2006
    ....
  93. pmc Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression
    Christopher Vollmers
    Regulatory Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:21453-8. 2009
    ..Livers of mice held under constant darkness exhibit circadian rhythm in abundance in up to 15% of expressed transcripts...
  94. ncbi Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways
    Lei Yin
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 318:1786-9. 2007
    ..Thus, Rev-erbalpha serves as a heme sensor that coordinates the cellular clock, glucose homeostasis, and energy metabolism...
  95. pmc Circadian oscillation of hippocampal MAPK activity and cAmp: implications for memory persistence
    Kristin L Eckel-Mahan
    Department of Pharmacology, University of Washington, 1959 NE Pacific St, Seattle, Washington 98195, USA
    Nat Neurosci 11:1074-82. 2008
    ..These data suggest that the persistence of long-term memories may depend on reactivation of the cAMP/MAPK/CREB transcriptional pathway in the hippocampus during the circadian cycle...
  96. ncbi Haematopoietic stem cell release is regulated by circadian oscillations
    Simon Mendez-Ferrer
    Mount Sinai School of Medicine, Department of Medicine and Department of Gene and Cell Medicine, New York, New York 10029, USA
    Nature 452:442-7. 2008
    ..These data indicate that a circadian, neurally driven release of HSC during the animal's resting period may promote the regeneration of the stem cell niche and possibly other tissues...
  97. pmc Chronic phase shifts of the photoperiod throughout pregnancy programs glucose intolerance and insulin resistance in the rat
    Tamara J Varcoe
    Research Centre for Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia
    PLoS ONE 6:e18504. 2011
    ..These results highlight the need for a thorough analysis of shift work exposure in utero on the health of the adult offspring in humans...
  98. ncbi Timing of plant immune responses by a central circadian regulator
    Wei Wang
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Nature 470:110-4. 2011
    ..Temporal control of the defence genes by CCA1 differentiates their involvement in basal and R-gene-mediated defence. Our study has revealed a key functional link between the circadian clock and plant immunity...
  99. pmc Emergence of noise-induced oscillations in the central circadian pacemaker
    Caroline H Ko
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Biol 8:e1000513. 2010
    ..The emergence of stochastic circadian oscillations from the SCN network in the absence of cell-autonomous circadian oscillatory function highlights a previously unrecognized level of circadian organization...
  100. ncbi Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study
    Ramon C Hermida
    Bioengineering and Chronobiology Laboratories, University of Vigo, Campus Universitario, Vigo, Spain
    Chronobiol Int 27:1629-51. 2010
    ....
  101. ncbi Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
    Gad Asher
    Department of Molecular Biology, University of Geneva, 1211 Geneva 4, Switzerland
    Cell 142:943-53. 2010
    ..Our results show that Parp-1 knockout mice exhibit impaired food entrainment of peripheral circadian clocks and support a role for PARP-1 in connecting feeding with the mammalian timing system...

Research Grants72

  1. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..nutrient status and energy metabolism to the brain which integrates the signals with central inputs of circadian rhythm and psychological stressors...
  2. Iron, Metabolic Regulation and Type 2 Diabetes Risk
    Donald A McClain; Fiscal Year: 2013
    ..pathways provide novel links between iron and the known diabetes risk factors of inflammation and disturbed circadian rhythm. We propose to study the mechanisms for these associations in animal models because it is crucial to ..
  3. Modulation of immune senescence by androgen treatment in aged male macaques
    Henryk F Urbanski; Fiscal Year: 2013
    ..a novel paradigm of androgen replacement in which testosterone and DHEA are administered to mimic the natural circadian rhythm of these hormones...
  4. Calcium Signaling in the Pubertal Activation of the GnRH Pulse Generator
    Daniel J Spergel; Fiscal Year: 2011
    ..neurons that convey information about age, growth, availability of metabolic fuels such as glucose and fats, circadian rhythm, and other factors...
  5. A Functional Role for the Circadian Clock Protein Per1 in the Regulation of ??ENa
    Michelle L Gumz; Fiscal Year: 2013
    ..Recent data suggest a role for the aldosterone target Period 1, a circadian rhythm gene, in mediating the aldosterone-dependent and independent regulation of the alpha subunit of ENaC ((ENaC), ..
  6. Circadian Rhythm in Cone Photoreceptors: Cellular Mechanisms
    GLADYS Y KO; Fiscal Year: 2012
    ..of this proposal is that protein kinase B (Akt)-related signaling is the major pathway that regulates the circadian rhythm of photoreceptor L-VGCCs, and intense light stimulation at night causes drastic changes of Akt- dependent ..
  7. Novel CNS Target for Sleep-Wake and Psychiatric Disorders
    SCOTT MCNEAR THACHER; Fiscal Year: 2010
    ..the SCN, or entraining and consolidating signals from the SCN, will have widespread therapeutic potential in circadian rhythm sleep disorders (CRSDs) such as delayed sleep phase disorder (DSPD), jet lag, shift work sleep disorder, and ..
  8. Genome-wide epigenetic control of circadian metabolism by heme receptor Rev-erb
    Mitchell A Lazar; Fiscal Year: 2010
    ..was identified by the PI in 1989, and has since emerged as an important repressor of key genes controlling circadian rhythm and glucose metabolism...
  9. HEMOPROTEIN OXIDATION AND HEME CATABOLISM
    Paul R Ortiz de Montellano; Fiscal Year: 2013
    ..HO-2 has been specifically shown to be involved in the regulation of a potassium channel and control of a circadian rhythm clock...
  10. PPAR delta functions in liver
    Chih Hao Lee; Fiscal Year: 2013
    ..Interestingly, the circadian rhythm of the hepatic lipogenic program correlates with the daily cycling of muscle fatty acid uptake/utilization, ..
  11. Effects of sleep deprivation and high fat diet on human CYP7A1 circadian rhythm
    JESSICA MARIE FERRELL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Circadian rhythm disturbances are associated with metabolic syndrome and obesity in humans, leading to altered homeostatic regulation of glucose, insulin, and lipids...
  12. Biology of nuclear receptor rev-erb alpha in circadian rhythm and metabolism
    Lei Yin; Fiscal Year: 2009
    ..Although several hypotheses link obesity and insulin resistance, the role of circadian rhythm in the pathogenesis of diabetes has not been well addressed...
  13. Investigating the Mechanisms Regulating RORgamma Activity
    LAURA ANN SOLT; Fiscal Year: 2013
    ..1, -2, and -3 (ROR1, ROR2, and ROR3), play important roles in regulating glucose and lipid metabolism, circadian rhythm, and have been implicated in the pathology of several diseases, including osteoporosis, autoimmune diseases, ..
  14. Biology of nuclear receptor rev-erb alpha in circadian rhythm and metabolism
    Lei Yin; Fiscal Year: 2011
    ..Although several hypotheses link obesity and Insulin resistance, the role of circadian rhythm in the pathogenesis of diabetes has not been well addressed...
  15. CELL BIOLOGY OF THE NEURONAL SODIUM CHANNEL
    William A Catterall; Fiscal Year: 2013
    ..the features of DS, including susceptibility to thermally induced seizures and spontaneous seizures, ataxia, circadian rhythm and sleep disorders, cognitive deficit, autistic-like features, and premature death...
  16. Functional role of the Spot 14 gene in dietary regulation of milk fat synthesis
    KEVIN JOHN HARVATINE; Fiscal Year: 2013
    ..decreased by substitution of dietary fat for carbohydrate, and milk fat concentration and profile follows a circadian rhythm on some diets...
  17. Treatment of Alcohol Induced Hepatic Injury with REV-ERB Ligands
    Thomas P Burris; Fiscal Year: 2013
    ..Alterations in the circadian rhythm of gene expression (both clock genes and metabolic genes) are associated with alterations in lipid metabolism ..
  18. Calcineurin's role in circadian regulation of cardiac function and remodeling
    Beverly A Rothermel; Fiscal Year: 2012
    ..tachycardia, and death from ischemic heart disease, vary according to the time of day, and forced changes in circadian rhythm are associated with increased risk for heart failure...
  19. Alteration of circadian rhythm and sleep by HIV protein Tat
    Jian M Ding; Fiscal Year: 2012
    ..individuals have a robust circadian oscillation of circulating lymphocytes with the peak at night, but this circadian rhythm is diminished in HIV-infected patients...
  20. CIRCADIAN-COUPLED CELLULAR AND LUNG FUNCTION IN COPD
    Irfan Rahman; Fiscal Year: 2012
    ..Patients with COPD have abnormal circadian rhythm, reflected in circadian changes in the airway caliber and resistance and respiratory symptoms...
  21. Sleep promotion in zebrafish by hypocretin neuronal networks
    Philippe Mourrain; Fiscal Year: 2012
    ..have shown that a genuine sleep-like state exists in this species, as defined using behavioral criteria (circadian rhythm, reversible periods of immobility, place preference, characteristic posture, increased arousal threshold, ..
  22. A chemical genetic approach to dissect CKId &CKIe function in circadian rhythm
    Ying Hui Fu; Fiscal Year: 2011
    ..substrates and studies aimed at understanding substrates that are important for the functional consequences of CKI?/? in circadian rhythm. We will also examine phenotypes resulting from reversibly inactivating these kinases in vivo.
  23. Role of circadian clocks in maintaining a healthy nervous system
    SVETLANA NIKOLAEVNA RADYUK; Fiscal Year: 2012
    ..We revealed a circadian rhythm in the expression of the catalytic (GCLc) and modulatory (GCLm) subunits of glutamate cysteine ligase (GCL), ..
  24. ROCK and Obesity
    JAMES KUANG JAN LIAO; Fiscal Year: 2013
    ..Furthermore, ROCK2 mice exhibit circadian rhythm disturbances, impaired adaptive thermogenesis, and 43% reduction in whole-body oxygen consumption;features ..
  25. Cycling of Circadian Rhythm Proteins
    Amita Sehgal; Fiscal Year: 2013
    ..Through a small molecule inhibitor screen, we have identified classes of kinase required for TIM degradation by light. We will identify the specific kinases involved. ..
  26. Regulation of RPE phagocytosis via avb5 integrin
    Silvia C Finnemann; Fiscal Year: 2012
    ..by the retinal pigment epithelium (RPE) to phagocytose photoreceptor outer segment fragments (POS) shed in a circadian rhythm in the mammalian eye and to understand how specific changes in these mechanisms due to aging and mutations ..
  27. Upper airway control during disrupted and misaligned sleep
    LESZEK K KUBIN; Fiscal Year: 2013
    ..sleep differs between the rest and active periods, and that it is depressed by sleep loss or when the circadian rhythm of sleep is abolished...
  28. Cellular Circadian Clocks in Mood Disorders
    David K Welsh; Fiscal Year: 2013
    ..by introducing a firefly luciferase reporter of Per2 clock gene expression, so that the cells glow with a circadian rhythm. Using a luminometer to measure the cells'bioluminescence, we will then be able to monitor cellular ..
  29. Mechanisms of Circadian Rhythmicity in CLOCK-Deficient Mice
    DAVID RAYMOND WEAVER; Fiscal Year: 2013
    ..Mice with disruption of two genes involved in circadian rhythm generation, CLOCK and NPAS2, not only lose their circadian rhythms, but they are also infertile and developed ..
  30. Hearing circadian rhythms.
    Barbara Canlon; Fiscal Year: 2013
    ..Exactly how this circadian rhythm in the auditory system is controlled is not known...
  31. Synapt G2-S System with HXMS Automation
    Elizabeth A Komives; Fiscal Year: 2013
    ..analyze the conformational changes in interleukins and kinases;Shan will map the substrate- and receptor- interactions in the chloroplast Signal Recognition Particle;and Kay will screen modulators of circadian rhythm-control proteins.
  32. Malaria melatonin receptor signaling as a novel drug target
    Andrew P Thomas; Fiscal Year: 2013
    ..to regulate parasite proliferation and entrain the Plasmodium cell cycle to be synchronized with the host circadian rhythm. Validation of pMTR as a potential target for small molecule drug therapy would represent a paradigm shift, ..
  33. Neural Mechanisms of Diurnality: Role of the Intergeniculate Leaflet
    ANDREW JASON GALL; Fiscal Year: 2013
    ..Disease (AD), Parkinson's Disease (PD), and other dementia related neurological disorders exhibit circadian rhythm dysfunction...
  34. Brain-gut circadian rhythm interactions in alcohol-induced gut leakiness
    Fred W Turek; Fiscal Year: 2013
    ..Identifying how alcohol affects these biological rhythms in these organs may help us design new treatments for alcoholic liver disease and other alcohol related diseases. ..
  35. Understanding the basis of circadian rhythms in the model system Arabidopsis
    ELAINE MUNSEY TOBIN; Fiscal Year: 2010
    ..To understand how degradation of the CCA1 and LHY proteins (which themselves cycle with a circadian rhythm) is regulated, c...
  36. Neuromodulators and Circadian Clocks: Roles in Retinal Function and Dysfunction
    P Michael Iuvone; Fiscal Year: 2013
    ..photoreceptor, and retinal pigment epithelial (RPE) cells, that modulate visual processing and generate a circadian rhythm of protection from photo-oxidative stress...
  37. Epidemiology and Genetics of Tanning Addiction
    Brenda Cartmel; Fiscal Year: 2012
    ..genes that are thought to be related to multiple types of addiction (members of the opioid pathway, and circadian rhythm genes) in tanning addiction...
  38. Modifying age-related changes in mouse neuroinflammation &functional behaviors
    Stephen J Bonasera; Fiscal Year: 2013
    ..Measures of overall behavior, including those of circadian rhythm, time budget, &properties (duration, frequency, etc...
  39. GENETIC AND MOLECULAR DISSECTION OF THE NEUROSPORA CLOCK
    Jay C Dunlap; Fiscal Year: 2013
    ..examined have been shown to possess the capacity for endogenous temporal control and organization known as a circadian rhythm. The cellular machinery responsible for generating rhythms is collectively known as the biological clock...
  40. Effects of the circadian clock and light on the production of estrogens
    Steven W Lockley; Fiscal Year: 2010
    ..We have gathered some preliminary evidence to suggest that there is an endogenous circadian rhythm in urinary estrone-3-glucuronide with a day-time peak that is 12 hours out of phase with the urinary 6- ..
  41. NR1D1 pathway in breast cancer
    Douglas S Conklin; Fiscal Year: 2012
    ..The normal function of this gene is to regulate circadian rhythm and fat storage...
  42. The Regulation of Human Hydroxysteroid Sulfotransferase by Nuclear Receptor ROR
    Wen Xie; Fiscal Year: 2012
    ..RORs were previously known to play a role in tissue development and circadian rhythm. Among three ROR isoforms, ROR? and ROR? are expressed in the liver, but their hepatic function remains ..
  43. 2012 Pineal Cell Biology Gordon Research ConferenceLinks to circadian clocks, sl
    Vincent M Cassone; Fiscal Year: 2011
    ..Metabolic disorders (metabolic syndrome, diabetes, obesity), sleep restriction and circadian rhythm disorders (e.g...
  44. Circadian Timing, Sleep, and Adiposity
    Kelly Glazer Baron; Fiscal Year: 2013
    ..Obesity is one of the nation's greatest health problems and sleep and circadian rhythm disturbances are thought to play a role in the development of obesity...
  45. Genetic and behavioral analysis of developmental ethanol exposure in Drosophila
    KIMBERLY DEVON MCCLURE; Fiscal Year: 2010
    ..commonly associated with fetal alcohol syndrome, such as learning and memory deficits, motor dysfunction, circadian rhythm deregulation, as well as eating and sleeping disturbances will be evaluated in both ethanol-reared and ..
  46. SLEEP, AGING AND CIRCADIAN RHYTHM DISORDERS
    Charles A Czeisler; Fiscal Year: 2013
    ..This research has important implications for the development of strategies to prevent, and therapies to treat, obesity and diabetes in older adults. ..
  47. Integration of Circadian Rhythm and Metabolism through Coactivator PGC-1alpha
    Jiandie D Lin; Fiscal Year: 2012
    ..Our study has the potential to elucidate key molecular components that link the circadian timing system to energy homeostasis, and to gain insights into pathogenic mechanisms of metabolic and cardiovascular diseases. ..
  48. Cross-talk between the circadian clock and the cAMP signaling pathway
    Satchidananda Panda; Fiscal Year: 2013
    ..In parallel, the self sustaining hepatic circadian clock mediates circadian rhythm in expression of metabolic genes- a number of which are regulated by CREB and CRTC2- with peak levels aligned ..
  49. Circadian disruption and bariatric surgery: impact on metabolism, clock biology
    Deanna Marie Arble; Fiscal Year: 2013
    ..risk for metabolic disorders are also observed within populations subjected to a disruption of their normal circadian rhythm (e.g., night-shift workers and patients with Night Eating Syndrome)...
  50. Establishing zebrafish as a model for rai1 gene dosage
    James A Lister; Fiscal Year: 2010
    ..variable developmental delays, mild craniofacial anomalies, obesity, and significant abnormalities in sleep, circadian rhythm, attention, and self-control...
  51. FASEB SRC on Melatonin Receptors: Actions and Therapeutics
    David Blask; Fiscal Year: 2011
    ..on the treatment and prevention of a wide range of diseases, including insomnia and other sleep disorders, circadian rhythm disturbances, neurological diseases, depression, cancer, immunological disorders, metabolic disorders and ..
  52. Circadian Rhythms and Sleep-Wake Cycles in Parkinson's Disease
    Aleksandar Videnovic; Fiscal Year: 2013
    ..skills in circadian biology, sleep medicine, and clinical research methodology so as to investigate potential circadian rhythm abnormalities in PD. Dr. Videnovic has assembled a team of researchers who will mentor him during this award...
  53. Circadian regulation of microRNA biogenesis and function
    Peter W Vanderklish; Fiscal Year: 2012
    ..these processes - including synaptic plasticity, neurogenesis, and memory formation - are also regulated by circadian rhythm. We have obtained evidence for a mechanistic link between translational control and circadian rhythm that ..
  54. Mapping and rescuing EMS-induced lethal mutations on the Drosophila X Chromosome
    Hugo J Bellen; Fiscal Year: 2010
    ..including homeotic genes, genes controlling numerous signaling pathways, trp and potassium channels, and circadian rhythm genes...
  55. CIRCADIAN REGULATION OF INNATE IMMUNE MECHANISMS OF VIRAL RECOGNITION
    Erol Fikrig; Fiscal Year: 2010
    ..Nearly all organisms have adapted their physiology and behavior to a circadian rhythm. Circadian (daily) rhythms refer to physiologic phenomena that oscillate with a period of 24 hours, providing ..
  56. Effects of Sleep Deprivation on Infection Induced Organ Failure
    Leigh A Callahan; Fiscal Year: 2013
    ..Recent studies indicate that critically ill patients experience poor sleep, frequent disruptions, loss of circadian rhythm and a marked reduction of the percentage of sleep time spent in restorative stages...
  57. Sensitization of Human Circadian Responses to Light
    Charles A Czeisler; Fiscal Year: 2013
    ..b>Circadian rhythm sleep disorders form a distinct class of sleep disorders characterized by misalignment between the timing of ..
  58. Regulation of Masking and Circadian Rhythm Phase
    Lawrence P Morin; Fiscal Year: 2012
    ..On the one hand, it has been considered to be either an inconvenience for circadian rhythm assessment insofar as it can obscure underlying events...
  59. Sleep Length and Circadian Regulation in Humans
    HELEN JULIA BURGESS; Fiscal Year: 2012
    SUMMARY Millions of Americans suffer from circadian rhythm sleep disorders, which include shift work sleep disorder, jet lag, delayed sleep phase syndrome and possibly winter depression...
  60. DETERMINATION AND EXPRESSION OF AMELOGENIN GENE PRODUCTS
    Malcolm L Snead; Fiscal Year: 2012
    ..a circadian cycle for amelogenin transcript abundance that cycles out of phase to the negative limb of the circadian rhythm. By binary gene ablation, we knocked-out C/EBP-alpha expression in ameloblasts and found that C/EBP-delta ..
  61. Circadian Phase Assessments at Home
    HELEN JULIA BURGESS; Fiscal Year: 2013
    ..by applicant): An estimated 23 million Americans, including adolescents and the elderly, suffer from circadian rhythm sleep disorders, such as delayed sleep phase disorder, advanced sleep phase disorder and winter depression...
  62. Period in Cardio Protection
    Tobias Eckle; Fiscal Year: 2013
    ..In this study, we present data from a microarray where we identified two circadian rhythm proteins, Period 1 and Period 2, as adenosine dependant molecules...
  63. Race Related Stressors and Preterm Birth in African American Women
    Carmen Giurgescu; Fiscal Year: 2009
    ..with preterm birth and women with full term birth when controlling for gestational age at data collection and circadian rhythm;and (6) preliminary evidence of the promise of our theoretical model with this sample...
  64. MOLECULAR ANALYSIS OF CONGENITAL ANOPHTHALMIA
    Thomas Glaser; Fiscal Year: 2004
    ..Affected mice lack eyes and optic tracts, have attenuated brain visual centers and primary circadian rhythm disturbances...
  65. Circadian rhythm genes and sleep disturbances in the elderly
    Gregory J Tranah; Fiscal Year: 2010
    ..Our specific aims are to test common genetic variants and haplotypes in 21 circadian rhythm and 4 melatonin metabolism genes for association with rest activity rhythms and sleep characteristics as ..
  66. Sleep Activity Patterns and Temperature in Childhood Onset Bipolar Disorder
    Patricia Murphy; Fiscal Year: 2009
    Sleep and circadian rhythm disturbances are common features of bipolar disorder. Childhood onset bipolar disorder (COBD), in particular, is characterized by symptoms suggestive of altered regulation of sleep and wakefulness...
  67. Photoreceptors Involved in Chlamydomonas reinhardtii Circadian Entrainment
    SIGRID JACOBSHAGEN; Fiscal Year: 2007
    ..The extent of adjustment will be monitored based on the circadian rhythm of phototaxis (swimming towards light) because its measurement has been automated...
  68. REGULATION OF RENAL BICARBONATE AND CHLORIDE ABSORPTION
    Robert Alpern; Fiscal Year: 2009
    ..Nocturnin is a circadian rhythm gene...
  69. MECHANISMS UNDERLYING THE CIRCADIAN RHYTHM OF IOP
    Douglas Gregory; Fiscal Year: 1999
    ..Measurement of tissue cyclic nucleotide levels in vivo provides a powerful tool for elucidating their role in control of the circadian rhythms of aqueous flow and IOP. ..
  70. CIRCADIAN MECHANISMS REGULATING OSTEOGENESIS
    Jeffrey Gimble; Fiscal Year: 2005
    ..Aim 1 will use real time PCR to document the temporal expression profile of circadian rhythm genes in murine bone...
  71. CIRCADIAN PATTERNS OF SLEEP TENDENCY IN THE ELDERLY
    Daniel Buysse; Fiscal Year: 2000
    ..The elderly may have a different pattern, marked by reduced amplitude of the circadian rhythm in sleep tendency...
  72. Circadian Regulation of Dopaminergic Activity and Restless Legs Syndrome
    Colleen McClung; Fiscal Year: 2009
    ..In this study we will determine if dopamine cells have an intrinsic circadian rhythm in activity and if a mutation in the CLOCK gene disrupts this rhythm...