immunological models

Summary

Summary: Theoretical representations that simulate the behavior or activity of immune system, processes, or phenomena. They include the use of mathematical equations, computers, and other electrical equipment.

Top Publications

  1. ncbi Tolerogenic dendritic cells
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021 6399, USA
    Annu Rev Immunol 21:685-711. 2003
  2. ncbi Modelling viral and immune system dynamics
    Alan S Perelson
    Theoretical Division, Los Alamos National Laboratory, New Mexico 87545, USA
    Nat Rev Immunol 2:28-36. 2002
  3. ncbi The dynamic life of natural killer cells
    Wayne M Yokoyama
    Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Department of Pathology and Immunology, St Louis, Missouri 63110, USA
    Annu Rev Immunol 22:405-29. 2004
  4. ncbi Danger signals: SOS to the immune system
    S Gallucci
    Ghost Laboratory, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 111, Bethesda, MD 20892, USA
    Curr Opin Immunol 13:114-9. 2001
  5. ncbi Age-related changes in lymphocyte development and function
    Phyllis Jean Linton
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Nat Immunol 5:133-9. 2004
  6. ncbi Toll-like receptors on regulatory T cells: expanding immune regulation
    Roger P M Sutmuller
    Tumor Immunology Laboratory, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Trends Immunol 27:387-93. 2006
  7. ncbi Prostaglandins as modulators of immunity
    Sarah G Harris
    Dept of Microbiology and the James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Trends Immunol 23:144-50. 2002
  8. ncbi Regulation of Th2 differentiation and Il4 locus accessibility
    K Mark Ansel
    Harvard Medical School, CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 24:607-56. 2006
  9. ncbi Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells
    M L Albert
    Laboratory of Neuro Oncology, The Rockefeller University, 1230 York Avenue, Box 26, New York, NY 10021, USA
    Nat Immunol 2:1010-7. 2001
  10. ncbi Transforming growth factor-beta regulation of immune responses
    Ming O Li
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 24:99-146. 2006

Research Grants

  1. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 2007
  2. A Therapeutic Vaccine for EBV-Associated Malignancies
    Paul M Lieberman; Fiscal Year: 2010
  3. Leprosy/Armadillo Support and Maintenance
    Patrick Brennan; Fiscal Year: 2009
  4. FLOURESCENT MARKERS OF T CELL ACTIVATION
    JEREMY BOSS; Fiscal Year: 2000
  5. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 2010
  6. Mathematical Models of Programmed CTL Proliferation
    Dominik Wodarz; Fiscal Year: 2009
  7. Immunoreceptors
    Michael Dustin; Fiscal Year: 2008
  8. Inverted two photon laser scanning microscope for host defense
    Michael Dustin; Fiscal Year: 2008
  9. Chemokine Receptor Chimeras by Synthetic Gene Library
    Michael Dustin; Fiscal Year: 2007
  10. Tools for Testing HIV Immune-Control and Vaccine Models
    W David Wick; Fiscal Year: 2009

Detail Information

Publications263 found, 100 shown here

  1. ncbi Tolerogenic dendritic cells
    Ralph M Steinman
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021 6399, USA
    Annu Rev Immunol 21:685-711. 2003
    ..We suggest that several clinical situations, including autoimmunity and certain infectious diseases, can be influenced by the antigen-specific tolerogenic role of DCs...
  2. ncbi Modelling viral and immune system dynamics
    Alan S Perelson
    Theoretical Division, Los Alamos National Laboratory, New Mexico 87545, USA
    Nat Rev Immunol 2:28-36. 2002
    ..Mathematical modelling is also improving our understanding of T-cell dynamics and the quantitative events that underlie the immune response to pathogens...
  3. ncbi The dynamic life of natural killer cells
    Wayne M Yokoyama
    Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Department of Pathology and Immunology, St Louis, Missouri 63110, USA
    Annu Rev Immunol 22:405-29. 2004
    ....
  4. ncbi Danger signals: SOS to the immune system
    S Gallucci
    Ghost Laboratory, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 111, Bethesda, MD 20892, USA
    Curr Opin Immunol 13:114-9. 2001
    ....
  5. ncbi Age-related changes in lymphocyte development and function
    Phyllis Jean Linton
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Nat Immunol 5:133-9. 2004
    ..This review aims to provide an overview of age-related changes in lymphocyte development and function and discusses current controversies in the field of aging research...
  6. ncbi Toll-like receptors on regulatory T cells: expanding immune regulation
    Roger P M Sutmuller
    Tumor Immunology Laboratory, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Trends Immunol 27:387-93. 2006
    ..This review examines the ramifications of TLR engagement on Treg cells and conventional T cells, and discusses the potential role of TLRs on Treg cells and the consequences for disease therapy...
  7. ncbi Prostaglandins as modulators of immunity
    Sarah G Harris
    Dept of Microbiology and the James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Trends Immunol 23:144-50. 2002
    ..Understanding the diverse activities of these prostaglandins is crucial for the development of new therapies aimed at immune modulation...
  8. ncbi Regulation of Th2 differentiation and Il4 locus accessibility
    K Mark Ansel
    Harvard Medical School, CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 24:607-56. 2006
    ....
  9. ncbi Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells
    M L Albert
    Laboratory of Neuro Oncology, The Rockefeller University, 1230 York Avenue, Box 26, New York, NY 10021, USA
    Nat Immunol 2:1010-7. 2001
    ....
  10. ncbi Transforming growth factor-beta regulation of immune responses
    Ming O Li
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 24:99-146. 2006
    ..This review highlights the findings that have advanced our understanding of TGF-beta in the immune system and in disease...
  11. ncbi A dynamical model of human immune response to influenza A virus infection
    Baris Hancioglu
    Department of Mathematics, 301 Thackeray, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Theor Biol 246:70-86. 2007
    ..This behavior is robust to a wide range of parameter values. The absence of antibody response leads to recurrence of disease and appearance of a chronic state with nontrivial constant viral load...
  12. ncbi Phylogenetic perspectives in innate immunity
    J A Hoffmann
    Institute of Molecular and Cellular Biology, CNRS, Strasbourg, 67084, France
    Science 284:1313-8. 1999
    ..In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity...
  13. pmc Eosinophils in the pathogenesis of allergic airways disease
    S G Trivedi
    Leukocyte Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Cell Mol Life Sci 64:1269-89. 2007
    ..Here we review the highly co-ordinated nature of eosinophil development and trafficking and the evolution of the eosinophil as a multi-factoral leukocyte with diverse functions in asthma...
  14. ncbi Activated TCRs remain marked for internalization after dissociation from pMHC
    Daniel Coombs
    Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Nat Immunol 3:926-31. 2002
    ..We show here that kinetic proofreading provides an explanation for the different requirements for activation observed in naïve and memory T cells...
  15. ncbi HIV disease: fallout from a mucosal catastrophe?
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 7:235-9. 2006
    ....
  16. ncbi Recirculation of germinal center B cells: a multilevel selection strategy for antibody maturation
    Michal Or-Guil
    Systems Immunology Group, Institute for Theoretical Biology, Humboldt University, Berlin, Germany
    Immunol Rev 216:130-41. 2007
    ..The concepts of iteration, all-or-none behavior, and phasic mutation schedule are discussed in the light of this hypothesis...
  17. ncbi Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses
    Seung Yong Seong
    Ghost Lab, Laboratory of Cellular and Molecular Immunology, National Insstitute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Rev Immunol 4:469-78. 2004
  18. ncbi Transforming growth factor beta--a mediator of immune deviation in seminal plasma
    Sarah A Robertson
    Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, Adelaide University, South Australia, Australia
    J Reprod Immunol 57:109-28. 2002
    ..A better understanding of the significance and role of TGFbeta in semen will facilitate development of novel therapies for immune-based infertility disorders...
  19. ncbi A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    J P Ridge
    Ghost Lab, Section on T cell Tolerance and Memory, Laboratory of Cellular and Molecular Immunology, NIAID NIH, Bethesda, Maryland 20892, USA
    Nature 393:474-8. 1998
    ....
  20. pmc Simulating T-cell motility in the lymph node paracortex with a packed lattice geometry
    Gib Bogle
    Maurice Wilkins Centre, University of Auckland, Auckland, New Zealand
    Immunol Cell Biol 86:676-87. 2008
    ..The model is computationally highly efficient and provides a suitable engine for a model capable of simulating the full T-cell population of the paracortex...
  21. ncbi A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage
    Lawrence Steinman
    Interdepartmental Program in Immunology, Department of Neurology and Neurological Sciences, Beckman Center for Molecular Medicine, Stanford University, Stanford, California 94305, USA
    Nat Med 13:139-45. 2007
    ..The evolution of our understanding of the T(H)17 pathway illuminates a shift in immunologists' perspectives regarding the basis of tissue damage, where for over 20 years the role of T(H)1 cells was considered paramount...
  22. ncbi Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression
    Z X Zhang
    Department of Laboratory of Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Hospital Research Institute, UHN, University of Toronto, Toronto, M5G, 2C4, Canada
    Nat Med 6:782-9. 2000
    ..These findings provide a novel mechanism of regulatory T-cell-mediated, antigen-specific suppression...
  23. ncbi NK cell recognition
    Lewis L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco School of Medicine, San Francisco, California 94143 0414, USA
    Annu Rev Immunol 23:225-74. 2005
    ..Here, I review the structure, function, and ligand specificity of the receptors responsible for NK cell recognition...
  24. ncbi Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
    Sanjeev Mariathasan
    Department of Translational Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Rev Immunol 7:31-40. 2007
    ..Here we review recent work on the activation of the inflammasome in response to various bacterial pathogens and tissue damage...
  25. ncbi TCR specificity dictates CD94/NKG2A expression by human CTL
    Bana Jabri
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Immunity 17:487-99. 2002
    ..These findings suggest that TCR antigenic specificity dictates NKG2A commitment, which critically regulates subsequent activation of CTL...
  26. ncbi Src and Syk kinases: key regulators of phagocytic cell activation
    Giorgio Berton
    Department of Pathology, Section of General Pathology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Trends Immunol 26:208-14. 2005
    ..Elucidating the regulation of these tyrosine kinase-based signaling pathways in leukocytes remains an important goal in understanding how immune cells respond to the multitude of activating agents they encounter...
  27. ncbi Turnover rates of B cells, T cells, and NK cells in simian immunodeficiency virus-infected and uninfected rhesus macaques
    Rob J de Boer
    Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    J Immunol 170:2479-87. 2003
    ..Because the viral load and the CD4 T cell count are negatively correlated we cannot determine which of the two plays the most important role in this generalized immune activation...
  28. ncbi MicroRNAs and immunity: tiny players in a big field
    Konstantin D Taganov
    Division of Biology, California Institute of Technology, 1200 East California Blvd, Pasadena, CA 91125, USA
    Immunity 26:133-7. 2007
    ..Here, Taganov et al. discuss the role of miRNAs in the innate immune response to microbial infection...
  29. ncbi Regulatory T cells in the control of immune pathology
    K J Maloy
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Immunol 2:816-22. 2001
    ..We will review here recent findings in these areas, outline a model for how T(R) cells may inhibit the development of immune pathology and discuss potential therapeutic benefits that may arise from the manipulation of T(R) cell function...
  30. ncbi Immunodominance in TCD8+ responses to viruses: cell biology, cellular immunology, and mathematical models
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Immunity 21:149-53. 2004
    ....
  31. ncbi Sequence space localization in the immune system response to vaccination and disease
    Michael W Deem
    Department of Bioengineering and Department of Physics and Astronomy, Rice University, Houston, Texas 77005 1892, USA
    Phys Rev Lett 91:068101. 2003
    ..This localization is a result of the roughness in sequence space of the evolved antibody affinity constant for antigen and is observed for diseases with high year-to-year mutation rates, such as influenza...
  32. pmc The receptor deformation model of TCR triggering
    Zhengyu Ma
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    FASEB J 22:1002-8. 2008
    ..By introducing mechanical force into a model of T cell signal initiation, the receptor deformation model provides potential mechanistic solutions to the sensitivity and specificity of TCR triggering...
  33. ncbi Regulatory T cells and organ transplantation
    Herman Waldmann
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX13RE, UK
    Semin Immunol 16:119-26. 2004
    ..The role of these cells is to moderate immune responses to prevent tissue destruction while allowing microbial elimination...
  34. ncbi Molecular mechanisms regulating Th1 immune responses
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health Boston, Massachusetts 02115, USA
    Annu Rev Immunol 21:713-58. 2003
    ..Although the picture is still incomplete, the basic pathways leading to Th1 differentiation can now be understood in in vitro and a number of infection and disease models...
  35. ncbi The human immune response to Mycobacterium tuberculosis in lung and lymph node
    Simeone Marino
    Department of Microbiology and Immunology, University of Michigan Medical School, 6730 Medical Science Building II, Ann Arbor, MI 48109 0620, USA
    J Theor Biol 227:463-86. 2004
    ..Then we use the model to predict key processes determining these different disease trajectories (i.e. identify bifurcation parameters), suggesting directions for further basic science study and potential new treatment strategies...
  36. ncbi A model to predict cell-mediated immune regulatory mechanisms during human infection with Mycobacterium tuberculosis
    J E Wigginton
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 166:1951-67. 2001
    ..A balance in Th1 and Th2 immune responses governed by IFN-gamma, IL-10, and IL-4 facilitate this down-regulation. These results are further explored through virtual deletion and depletion experiments...
  37. ncbi Imaging of germinal center selection events during affinity maturation
    Christopher D C Allen
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Science 315:528-31. 2007
    ..On the basis of these observations, we propose a model in which competition for T cell help plays a more dominant role in the selection of GC B cells than previously appreciated...
  38. ncbi CD4 memory T cells on trial: immunological memory without a memory T cell
    Eric B Bell
    Faculty of Life Sciences, Immunology Section, University of Manchester, Manchester M13 9PT, UK
    Trends Immunol 29:405-11. 2008
    ..In addition, residual antigen will significantly influence the longevity of a memory response. Our model offers a new insight into immunological memory that could assist the development of CD4 T cell-based vaccines...
  39. ncbi Statistical analysis of antigen receptor spectratype data
    Thomas B Kepler
    Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708, USA
    Bioinformatics 21:3394-400. 2005
    ..The purpose of this paper is to describe the systematic derivation and application of statistical methods for the analysis of spectratype data...
  40. ncbi Modelling antigenic drift in weekly flu incidence
    B F Finkenstädt
    Department of Statistics, University of Warwick, Coventry CV4 7AL, UK
    Stat Med 24:3447-61. 2005
    ..The SIR-S approach adopted here can also be shown to improve forecasting in comparison to conventional methods...
  41. pmc T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell
    Pablo A González
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8331010, Chile
    Proc Natl Acad Sci U S A 102:4824-9. 2005
    ..According to these results, effective T cell activation depends on a complex interplay between inherent TCR-pMHC binding kinetics and the epitope density on the APC...
  42. ncbi Division of labor with a workforce of one: challenges in specifying effector and memory T cell fate
    Steven L Reiner
    Abramson Family Cancer Research Institute of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 317:622-5. 2007
    ....
  43. ncbi The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms
    Britta Engelhardt
    Theodor Kocher Institute, University of Bern, CH 3012 Bern, Switzerland
    Trends Immunol 26:485-95. 2005
    ..An update on findings from clinical trials of natalizumab is also provided...
  44. pmc Review series on helminths, immune modulation and the hygiene hypothesis: immunity against helminths and immunological phenomena in modern human populations: coevolutionary legacies?
    Joseph A Jackson
    School of Biology, The University of Nottingham, University Park, Nottingham, UK
    Immunology 126:18-27. 2009
    ..The absence of immunoregulatory stimuli from helminths may therefore uncover maladaptations that were not previously exposed to selection...
  45. ncbi IgG Fc receptors
    J V Ravetch
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Annu Rev Immunol 19:275-90. 2001
    ..Fc gamma Rs offer a paradigm for the biological significance of balancing activation and inhibitory signaling in the expanding family of activation/inhibitory receptor pairs found in the immune system...
  46. ncbi T-cell regulation by CD28 and CTLA-4
    M L Alegre
    Department of Medicine, Section of Rheumatology and Committee in Immunology, Chicago, Illinois 60637, USA
    Nat Rev Immunol 1:220-8. 2001
    ....
  47. ncbi Cytokines and autoimmunity
    JOHN J O'SHEA
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch and Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:37-45. 2002
    ..The balance between the pro-inflammatory and immunosuppressive functions of these well-known cytokines and the implications for the pathogenesis of autoimmune disease is the focus of this review...
  48. ncbi Type I interferons (alpha/beta) in immunity and autoimmunity
    Argyrios N Theofilopoulos
    Immunology Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Immunol 23:307-36. 2005
    ....
  49. pmc Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells
    Helmut Jonuleit
    Department of Dermatology, University of Mainz, 55101 Mainz, Germany
    J Exp Med 196:255-60. 2002
    ..This explains previously published conflicting data on the role of TGF-beta in CD25(+) Treg cell-induced immunosuppression...
  50. ncbi Measurement and modeling of human T cell kinetics
    Derek C Macallan
    Department of Infectious Diseases, St George s Hospital Medical School, London, GB
    Eur J Immunol 33:2316-26. 2003
    ..The new kinetic model fits the data closely and avoids the need to postulate a large external source of lymphocytes to maintain equilibrium...
  51. ncbi Target cell limited and immune control models of HIV infection: a comparison
    R J De Boer
    Theoretical Biology, Utrecht University, Padualaan 8, CH Utrecht, 3584, The Netherlands
    J Theor Biol 190:201-14. 1998
    ..Additionally, we find that both types of models can adequately describe the clinically observed changes in the plasma HIV-1 RNA loads in response to retroviral therapies...
  52. ncbi Ecoimmunology: is there any room for the neuroendocrine system?
    Enzo Ottaviani
    Department of Animal Biology, University of Modena and Reggio Emilia, Italy
    Bioessays 30:868-74. 2008
    ....
  53. ncbi The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    Arlene H Sharpe
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Immunol 8:239-45. 2007
    ..Here we examine the functions of PD-1 and its ligands in regulating antimicrobial and self-reactive T cell responses and discuss the therapeutic potential of manipulating this pathway...
  54. ncbi Quantifying the relevance of different mediators in the human immune cell network
    P Tieri
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via San Giacomo 12, 40126 Bologna, Italy
    Bioinformatics 21:1639-43. 2005
    ..Nevertheless, a quantitative analysis of the topological properties of an immunological network involving this complex interchange of mediators among immune cells is still lacking...
  55. ncbi A review of immune cells and molecules in women with recurrent miscarriage
    S M Laird
    Biomedical Research Centre BMRC, Sheffield Hallam University, Sheffield, UK
    Hum Reprod Update 9:163-74. 2003
    ....
  56. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression...
  57. ncbi NF-kappaB regulation in the immune system
    Qiutang Li
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Immunol 2:725-34. 2002
    ..We also discuss the role of NF-kappaB proteins as potential therapeutic targets in clinical applications...
  58. ncbi Contribution of receptor editing to the antibody repertoire
    R Casellas
    Laboratory of Molecular Immunology, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA
    Science 291:1541-4. 2001
    ..These results suggest that receptor editing represents a major force in shaping the antibody repertoire...
  59. ncbi IL-12p40: an inherently agonistic cytokine
    Andrea M Cooper
    Trudeau Institute Inc, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Trends Immunol 28:33-8. 2007
    ..An appreciation of the independent function of IL-12p40 is important for improving our understanding of both protective and pathogenic immune responses...
  60. pmc Estimation of the rate of killing by cytotoxic T lymphocytes in vivo
    Roland R Regoes
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:1599-603. 2007
    ..These models allow us to estimate the rate constant for killing of target cells by CTL...
  61. ncbi Tolerance and immunity in a mathematical model of T-cell mediated suppression
    Kalet Leon
    Centro de Inmunologia Molecular, PO Box 16040, Habana, Cuba
    J Theor Biol 225:107-26. 2003
    ..This result highlights the importance of repertoire selection in dominant tolerance proposing a novel role for the processes of positive and negative selection within this framework...
  62. pmc Deriving a germinal center lymphocyte migration model from two-photon data
    Marc Thilo Figge
    Frankfurt Institute for Advanced Studies, Frankfurt am Main, Germany
    J Exp Med 205:3019-29. 2008
    ..In addition, we discuss some statistical limitations for the interpretation of two-photon cell motility measurements in general...
  63. ncbi Spatial models of virus-immune dynamics
    Georg A Funk
    School of Biological Sciences, Royal Holloway University of London, Egham Surrey TW20 0EX, UK
    J Theor Biol 233:221-36. 2005
    ..Finally, we discuss the implications of spatially structured models on medical treatment of infectious diseases, and note that a huge gap exists in data accurately describing infection dynamics in solid tissues...
  64. pmc Prevalence and boosting of antibodies to Plasmodium falciparum glycosylphosphatidylinositols and evaluation of their association with protection from mild and severe clinical malaria
    J Brian de Souza
    Department of Immunology and Molecular Pathology, Royal Free and University College London Medical School, London W1T 4JF, United Kingdom
    Infect Immun 70:5045-51. 2002
    ..Further case-control studies, ideally of a prospective nature, are required to elucidate the role of antiglycolipid antibodies in protection from severe malaria...
  65. ncbi The flip side of immune surveillance: immune dependency
    Richmond T Prehn
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98118, USA
    Immunol Rev 222:341-56. 2008
    ..This knowledge may help to explain some clinical observations concerning the relationships among tumor types and the organ distribution of metastases...
  66. ncbi IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    Yong Jun Liu
    Department of Immunology and Center for Cancer Immunology Research, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Annu Rev Immunol 23:275-306. 2005
    ..Understanding IPC biology holds future promise for developing cures for infectious diseases, cancer, and autoimmune diseases...
  67. ncbi Epstein-Barr virus: exploiting the immune system
    D A Thorley-Lawson
    Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nat Rev Immunol 1:75-82. 2001
    ....
  68. ncbi Two-step binding mechanism for T-cell receptor recognition of peptide MHC
    Lawren C Wu
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, B221 Beckman Center, Stanford, California 94305, USA
    Nature 418:552-6. 2002
    ....
  69. ncbi Cross-presentation in viral immunity and self-tolerance
    W R Heath
    Immunology Division, The Walter and Eliza Hall Institute, Melbourne Hospital, Parkville, Victoria, Australia
    Nat Rev Immunol 1:126-34. 2001
    ..This function, known as cross-presentation, provides the immune system with an important mechanism for generating immunity to viruses and tolerance to self...
  70. pmc Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice
    Gabrielle T Belz
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 76:12388-93. 2002
    ..These findings are consistent with mathematical models that predict virus-host dynamics in this, and other, models of infection...
  71. ncbi Migration of dendritic cell subsets and their precursors
    Gwendalyn J Randolph
    Department of Gene and Cell Medicine, Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Annu Rev Immunol 26:293-316. 2008
    ..Finally, to gain a more molecular appreciation of the specialized migratory properties of DCs, we review the signaling cascades that govern the process of DC migration...
  72. ncbi On T-cell dynamics and the hyperactivation theory of AIDS pathogenesis
    D Wick
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104 2092, USA
    Math Biosci 158:127-44. 1999
    ..Memory-cell 'amnesia' is not required. T-cell lifetimes come out much shorter than previously estimated...
  73. ncbi In vivo developmental stages in murine natural killer cell maturation
    Sungjin Kim
    Howard Hughes Medical Institute and Rheumatology Division, Department of Internal Medicine, Barnes Jewish Hospital and Washington University School of Medicine, St Louis, MO 63110, USA
    Nat Immunol 3:523-8. 2002
    ....
  74. ncbi Altered TCR signaling from geometrically repatterned immunological synapses
    Kaspar D Mossman
    Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA
    Science 310:1191-3. 2005
    ..These results are consistent with a model of the synapse in which spatial translocation of TCRs represents a direct mechanism of signal regulation...
  75. ncbi Effective membrane model of the immunological synapse
    Subhadip Raychaudhuri
    Department of Chemical Engineering, University of California Berkeley, Berkeley, California 94720, USA
    Phys Rev Lett 91:208101. 2003
    ..We obtain a minimalist model that captures this experimentally observed phenomenology. A functional renormalization group analysis provides further insights...
  76. ncbi Autoimmune inflammation from the Th17 perspective
    Janette Furuzawa-Carballeda
    Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15 Tlalpan, Mexico City 14000, Mexico
    Autoimmun Rev 6:169-75. 2007
    ..The IL-17/23 axis of inflammation and related molecules may rise as therapeutic targets for treating these and perhaps other autoimmune diseases...
  77. ncbi Toll-like receptors in systemic autoimmune disease
    Ann Marshak-Rothstein
    Department of Microbiology, Boston University School of Medicine, 80 East Concord Street, Boston, Massachusetts 02118, USA
    Nat Rev Immunol 6:823-35. 2006
    ....
  78. ncbi Role of C5a in inflammatory responses
    Ren Feng Guo
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    Annu Rev Immunol 23:821-52. 2005
    ..Herein, we review human and animal data describing the cellular and molecular mechanisms of C5a in the development of inflammatory disorders, sepsis, acute lung injury, ischemia-reperfusion injury, and asthma...
  79. ncbi The kinetic-segregation model: TCR triggering and beyond
    Simon J Davis
    Nuffield Department of Clinical Medicine, The University of Oxford, and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    Nat Immunol 7:803-9. 2006
    ..We also consider the capacity of the model, versus that of other proposals, to account for the established features of TCR triggering...
  80. ncbi Models of CD8+ responses: 1. What is the antigen-independent proliferation program
    Rustom Antia
    Department of Biology, Emory University, Atlanta, GA, 30322, USA
    J Theor Biol 221:585-98. 2003
    ..Finally we examine some of the consequences of the "program" for pathogen-host coevolution...
  81. ncbi Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?
    C Benoist
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, One Joslin Place, Boston, MA, USA
    Nat Immunol 2:797-801. 2001
    ..Nonetheless, many of the associations appear less than convincing and, even for those that seem to be on solid footing, there is no real understanding of the underlying mechanism(s)...
  82. ncbi Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis
    J J Goronzy
    Departments of Medicine and Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Trends Immunol 22:251-5. 2001
    ..Increased risk of autoimmunity, as a consequence of abnormal T-cell population dynamics, could be a common mechanism in chronic inflammatory diseases...
  83. ncbi Autoimmunity during lymphopenia: a two-hit model
    Tom Krupica
    Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Clin Immunol 120:121-8. 2006
    ....
  84. ncbi Toll-like receptors and innate immunity
    R Medzhitov
    Section of Immunobiology, Yale University School Medicine, and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Rev Immunol 1:135-45. 2001
    ..Recognition of microbial products by Toll-like receptors expressed on dendritic cells triggers functional maturation of dendritic cells and leads to initiation of antigen-specific adaptive immune responses...
  85. pmc The Basic Immune Simulator: an agent-based model to study the interactions between innate and adaptive immunity
    Virginia A Folcik
    Pulmonary, Allergy, Critical Care and Sleep Medicine Division, Department of Internal Medicine, The Ohio State University College of Medicine, 3102 Cramblett Hall, 456 W 10th St, Columbus, Ohio 43210, USA
    Theor Biol Med Model 4:39. 2007
    ..The BIS includes a Graphical User Interface (GUI) to facilitate its use as an educational and research tool...
  86. ncbi Homeostatic proliferation and survival of naïve and memory T cells
    Onur Boyman
    Division of Immunology and Allergy, University Hospital of Lausanne CHUV, CH 1011 Lausanne, Switzerland
    Eur J Immunol 39:2088-94. 2009
    ..Thus, the factors controlling T-cell homeostasis can be seen to vary considerably from one subset to another as described in detail in this review...
  87. pmc Adoptive immunotherapy of cancer using CD4(+) T cells
    Pawel Muranski
    National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Curr Opin Immunol 21:200-8. 2009
    ....
  88. ncbi NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment
    A I Roberts
    Department of Medicine, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    J Immunol 167:5527-30. 2001
    ..Uncontrolled secretion of IL-15 could lead to excessive induction of NKG2D and thus contribute to the development of autoimmune disease by facilitating the activation of autoreactive T cells...
  89. ncbi Natural endogenous adjuvants
    Kenneth L Rock
    Department of Pathology, UMass Medical School, Worcester, MA 01655, USA
    Springer Semin Immunopathol 26:231-46. 2005
    ..The potential biological roles of this class of adjuvants are discussed...
  90. ncbi No one is naive: the significance of heterologous T-cell immunity
    Raymond M Welsh
    Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA
    Nat Rev Immunol 2:417-26. 2002
    ..Here, we discuss evidence from studies in mice and humans that shows the importance of this phenomenon in determining the outcome of infection...
  91. ncbi CD4+ CD25+ suppressor T cells: more questions than answers
    Ethan M Shevach
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:389-400. 2002
    ....
  92. ncbi How do natural killer cells find self to achieve tolerance?
    Wayne M Yokoyama
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Immunity 24:249-57. 2006
    ..Although these studies begin to clarify the means by which NK cell tolerance is achieved, much more investigation is needed because NK cell tolerance is relevant to clinical observations in patients with infections and cancer...
  93. ncbi Cytokines as a link between innate and adaptive antitumor immunity
    Filippo Belardelli
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Trends Immunol 23:201-8. 2002
    ..With regard to type I interferons - cytokines with a long history of clinical use - this new knowledge could be translated easily into novel strategies for the prevention and treatment of human malignancies...
  94. pmc Naïve and memory cell turnover as drivers of CCR5-to-CXCR4 tropism switch in human immunodeficiency virus type 1: implications for therapy
    Ruy M Ribeiro
    Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    J Virol 80:802-9. 2006
    ..We also investigate the effects of different antiviral strategies. Surprisingly, these results suggest that both conventional antiretroviral regimens and CCR5 receptor-blocking drugs will promote R5 virus over X4 virus...
  95. ncbi Strength of signal: a fundamental mechanism for cell fate specification
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    Immunol Rev 209:170-5. 2006
    ..In this review, we compare the alphabeta/gammadelta fate decision with other cell fate decisions that occur outside of the lymphoid system to attain a better picture of the quantitative signaling mechanism for cell fate specification...
  96. ncbi Resource competition determines selection of B cell repertoires
    R J De Boer
    Theoretical Biology, Utrecht University, The Netherlands
    J Theor Biol 212:333-43. 2001
    ....
  97. ncbi Dynamical behaviour of epidemiological models with sub-optimal immunity and nonlinear incidence
    M G M Gomes
    Instituto Gulbenkian de Ciencia, Apartado 14, 2781 901 Oeiras, Portugal
    J Math Biol 51:414-30. 2005
    ..In these models we assume that the force of infection is a nonlinear function of density of infectious individuals, I. Conditions for the existence of backwards bifurcations, oscillations and Bogdanov-Takens points are given...
  98. pmc Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells
    S M Kaech
    Emory Vaccine Center, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    Nat Immunol 2:415-22. 2001
    ..These data indicate that initial antigen encounter triggers an instructive developmental program that does not require further antigenic stimulation and does not cease until memory CD8+ T cell formation...
  99. ncbi Immunology: how do T cells recognize antigen?
    Kaushik Choudhuri
    Sir William Dunn School of Pathology, University of Oxford, UK
    Curr Biol 15:R382-5. 2005
    ..The mechanism by which these receptors signal into T cells is controversial, but two recent studies provide important new clues...
  100. ncbi Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
    Almudena R Ramiro
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10021, USA
    Nat Immunol 4:452-6. 2003
    ..coli RNA polymerase. Our results establish a direct link between AID and transcription and suggest that the role of transcription in facilitating mutation is to provide AID with access to single-stranded DNA...
  101. ncbi A spatial model of germinal center reactions: cellular adhesion based sorting of B cells results in efficient affinity maturation
    Can Kesmir
    Department of Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands
    J Theor Biol 222:9-22. 2003
    ..We here show that this all-or-none behavior can be obtained if B cells are sorted based on their affinity on the FDC surface. Affinity-proportional selection models, in contrast, always produce mixed GCs...

Research Grants25

  1. PATHOGENIC MECHANISMS OF ANAEROBES IN SEPSIS
    Dennis Kasper; Fiscal Year: 2007
    ..abstract_text> ..
  2. A Therapeutic Vaccine for EBV-Associated Malignancies
    Paul M Lieberman; Fiscal Year: 2010
    ..This new vaccine strategy will be tested in mouse and rhesus macaques, which serve as the most relevant immunological models for human infection and viral- carcinogenesis...
  3. Leprosy/Armadillo Support and Maintenance
    Patrick Brennan; Fiscal Year: 2009
    ..Also supports collaborative research to continuously improve biochemical, microbiological and immunological models for leprosy research in an effort to provide the most up-to-date resource and expertise for mycobacterial ..
  4. FLOURESCENT MARKERS OF T CELL ACTIVATION
    JEREMY BOSS; Fiscal Year: 2000
    ..Because these measurements are critical in most immunological models that employ Tg and gene disrupted strains of mice, other assays are required...
  5. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 2010
    ..The influx of mathematicians and computer modelers is clearly changing the way we analyze immune behavior. ..
  6. Mathematical Models of Programmed CTL Proliferation
    Dominik Wodarz; Fiscal Year: 2009
    ..These are the role of effector molecules (such as perform and IFN-g) for CTL dynamics, and the role of CD4 T cell help. The modeling work will be complemented by experiments with VSV and LCMV infected mice. ..
  7. Immunoreceptors
    Michael Dustin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  8. Inverted two photon laser scanning microscope for host defense
    Michael Dustin; Fiscal Year: 2008
    ..The impact on public health will be to develop better strategies to fight infections and reduce the incidence of pathogen triggered autoimmunity. [unreadable] [unreadable] [unreadable]..
  9. Chemokine Receptor Chimeras by Synthetic Gene Library
    Michael Dustin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. Tools for Testing HIV Immune-Control and Vaccine Models
    W David Wick; Fiscal Year: 2009
    ..These theoretical models and experimental protocols should aid in understanding the outcome of a T-cell vaccine trial and in formulating better candidate vaccines. ..
  11. FASEB Research Conference: Lymphocytes and Antibodies
    Leo Lefrancois; Fiscal Year: 2004
    ..In Vivo T Cell Activation - Marc Jenkins (UMINN), Session Organizer 9. Cytokine Control of Immunity - Leo Lefrancois (UCHC), Session Organizer ..
  12. Mechanisms of immunomodulatory and anti-tumor actions of Polysaccharide Krestin
    Mary L Disis; Fiscal Year: 2010
    ..Results from these studies will help us understand the immune modulating effect of PSK and contribute to the clinical translation of this CAM molecule as an anti-cancer agent and/or a vaccine adjuvant. ..
  13. MIDCAREER INVESTIGATOR AWARD IN PATIENT ORIENTED RESEARC
    MARY DISIS; Fiscal Year: 2004
    ....
  14. HER2 VACCINATION FOR THE TREATMENT OF CANCER
    MARY DISIS; Fiscal Year: 2004
    ....
  15. Immunologic Correlates of Immunization for Cancer
    MARY DISIS; Fiscal Year: 2006
    ..abstract_text> ..
  16. Multi-Antigen Vaccines for Breast Cancer
    MARY DISIS; Fiscal Year: 2007
    ..abstract_text> ..
  17. Planning Grant for Institutional Clinical and Translational Science Award
    MARY DISIS; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  18. Phase I Trial of a HER2 ICD Plasmid-Based DNA Vaccine
    MARY DISIS; Fiscal Year: 2007
    ..The long-term goal will be to use this study as a platform to develop multi-antigen plasmid based vaccines for the prevention of common solid tumors. ..
  19. Cardiac Inflammation in Resuscitated Hemorrhagic Shock
    Douglas Mann; Fiscal Year: 2008
    ..Taken together, Specific Aims 1-4 should provide definitive new information regarding the mechanisms of activation, as well as the role of the innate immune system in resuscitated hemorrhagic shock. ..
  20. Chemokine Dynamics in the HIV-1/SIV Infected Lung
    Denise Kirschner; Fiscal Year: 2006
    ..End of Abstract) [unreadable] [unreadable]..
  21. Functional studies on normal neural aneuploidy
    Jerold Chun; Fiscal Year: 2007
    ..This proposal will provide a framework for, and data towards, understanding the functional importance of neural aneuploidy in the nervous system. ..
  22. HPV DNA VACCINE FOR CERVICAL PRE NEOPLASIA
    Jeffrey Weber; Fiscal Year: 2003
    ..To insure that spontaneous regression does not account for a portion of the responses, baseline measurements will be followed one month later by a second set of assessments prior to the start of the vaccine. ..
  23. AMID in Apoptosis and p53-Mediated Downstream Effects
    Philippa Marrack; Fiscal Year: 2009
    ..Successful completion of the proposed studies will help to understand the molecular mechanisms of caspase-independent apoptosis and roles of AMID in p53-mediated biological effects and tumorigenesis. ..
  24. Dengue Virus Determinants of Virulence and Transmission
    Rebeca Rico Hesse; Fiscal Year: 2009
    ..Hypothesis: Aedes aegypti saliva facilitates and/or potentiates dengue virus infection of initial target (dendritic) cells. ..