cardiovascular models

Summary

Summary: Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.

Top Publications

  1. ncbi A general model for the origin of allometric scaling laws in biology
    G B West
    Theoretical Division, T 8, Mail Stop B285, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 276:122-6. 1997
  2. pmc Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a longitudinal study
    Loic Boussel
    Department of Radiology, VA Medical Center, San Francisco, USA 94121, USA
    Stroke 39:2997-3002. 2008
  3. ncbi Finite element modeling of three-dimensional pulsatile flow in the abdominal aorta: relevance to atherosclerosis
    C A Taylor
    Department of Surgery, Stanford University, CA, USA
    Ann Biomed Eng 26:975-87. 1998
  4. ncbi From mouse to whale: a universal scaling relation for the PR Interval of the electrocardiogram of mammals
    Sami F Noujaim
    Institute for Cardiovascular Research and Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Circulation 110:2802-8. 2004
  5. ncbi Minimal model for human ventricular action potentials in tissue
    Alfonso Bueno-Orovio
    Departamento de Matematicas, Universidad de Castilla La Mancha, Ciudad Real, Spain
    J Theor Biol 253:544-60. 2008
  6. ncbi Remodeling of blood vessels: responses of diameter and wall thickness to hemodynamic and metabolic stimuli
    Axel R Pries
    Department of Physiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Hypertension 46:725-31. 2005
  7. ncbi Wall shear stress--an important determinant of endothelial cell function and structure--in the arterial system in vivo. Discrepancies with theory
    Robert S Reneman
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    J Vasc Res 43:251-69. 2006
  8. pmc Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging
    Dao Fu Dai
    Department of Pathology, University of Washington, Seattle, 98195, USA
    Circulation 119:2789-97. 2009
  9. pmc Ionic current basis of electrocardiographic waveforms: a model study
    Kazutaka Gima
    Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    Circ Res 90:889-96. 2002
  10. ncbi Mechanotransduction and the glycocalyx
    J M Tarbell
    Biomedical Engineering Department, The City College of New York, CUNY, New York, NY 10031, USA
    J Intern Med 259:339-50. 2006

Research Grants

  1. Role of Nitric Oxide and Cyclic GMP in Stem Cells
    David G Gorenstein; Fiscal Year: 2010
  2. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2008
  3. INVERSE AND FORWARD PROBLEMS IN ELECTROCARDIOGRAPHY
    Yoram Rudy; Fiscal Year: 2007
  4. Controlled Reperfusion for Whole Body Ischemic Injury
    Gerald Buckberg; Fiscal Year: 2005
  5. Noninvasive Quantification of the Resistance Baroeflex
    Ramakrishna Mukkamala; Fiscal Year: 2006
  6. Continuous Cardiac Output & Filling Pressure Monitoring
    Ramakrishna Mukkamala; Fiscal Year: 2007
  7. Analysis of Large-Scale Biochemical Systems
    DANIEL BEARD; Fiscal Year: 2007
  8. A Novel Polymeric Trileaflet Heart Valve Prosthesis
    SCOTT CORBETT; Fiscal Year: 2008
  9. Platelet adhesion in experimental colitis
    D Granger; Fiscal Year: 2008
  10. ENDOTHELIAL GENE REGULATION BY BIOMECHANICAL FORCES
    MICHAEL GIMBRONE; Fiscal Year: 2003

Detail Information

Publications268 found, 100 shown here

  1. ncbi A general model for the origin of allometric scaling laws in biology
    G B West
    Theoretical Division, T 8, Mail Stop B285, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 276:122-6. 1997
    ..More generally, the model predicts structural and functional properties of vertebrate cardiovascular and respiratory systems, plant vascular systems, insect tracheal tubes, and other distribution networks...
  2. pmc Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a longitudinal study
    Loic Boussel
    Department of Radiology, VA Medical Center, San Francisco, USA 94121, USA
    Stroke 39:2997-3002. 2008
    ..Low wall shear stress (WSS) has been reported to have a negative effect on endothelial cells normal physiology and may be an important contributor to local remodeling of the arterial wall and to aneurysm growth and rupture...
  3. ncbi Finite element modeling of three-dimensional pulsatile flow in the abdominal aorta: relevance to atherosclerosis
    C A Taylor
    Department of Surgery, Stanford University, CA, USA
    Ann Biomed Eng 26:975-87. 1998
    ..Monogr. Atheroscler. 15:13-19, 1990). This numerical investigation provides detailed quantitative data on hemodynamic conditions in the abdominal aorta heretofore lacking in the study of the localization of atherosclerotic disease...
  4. ncbi From mouse to whale: a universal scaling relation for the PR Interval of the electrocardiogram of mammals
    Sami F Noujaim
    Institute for Cardiovascular Research and Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Circulation 110:2802-8. 2004
    ..Hierarchical branching networks have been proposed to be the underlying mechanism for the 1/4 power allometric law...
  5. ncbi Minimal model for human ventricular action potentials in tissue
    Alfonso Bueno-Orovio
    Departamento de Matematicas, Universidad de Castilla La Mancha, Ciudad Real, Spain
    J Theor Biol 253:544-60. 2008
    ..The MV model also can be fitted to reproduce the dynamics of other models and is computationally more efficient: the times required to simulate the MV, TNNP, PB and IMW models follow the ratio 1:31:50:8084...
  6. ncbi Remodeling of blood vessels: responses of diameter and wall thickness to hemodynamic and metabolic stimuli
    Axel R Pries
    Department of Physiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Hypertension 46:725-31. 2005
    ....
  7. ncbi Wall shear stress--an important determinant of endothelial cell function and structure--in the arterial system in vivo. Discrepancies with theory
    Robert S Reneman
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    J Vasc Res 43:251-69. 2006
    ..Applications of wall shear stress as in flow-mediated arterial dilation, clinically in use to assess endothelial cell (dys)function, are also addressed. This review starts with some background considerations and some theoretical aspects...
  8. pmc Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging
    Dao Fu Dai
    Department of Pathology, University of Washington, Seattle, 98195, USA
    Circulation 119:2789-97. 2009
    ..We have previously shown that overexpression of catalase targeted to mitochondria (mCAT) prolongs murine median lifespan by 17% to 21%...
  9. pmc Ionic current basis of electrocardiographic waveforms: a model study
    Kazutaka Gima
    Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    Circ Res 90:889-96. 2002
    ..5) Activation of the ATP-sensitive potassium current, I(K(ATP)), is sufficient to cause ST elevation during acute ischemia. These principles provide a mechanistic cellular basis for interpretation of electrocardiographic waveforms...
  10. ncbi Mechanotransduction and the glycocalyx
    J M Tarbell
    Biomedical Engineering Department, The City College of New York, CUNY, New York, NY 10031, USA
    J Intern Med 259:339-50. 2006
    ..This review focuses on mechanotransduction of shear stress by ECs and considers the evidence in support of the surface glycocalyx acting as a mechanotransducer...
  11. ncbi Microvascular blood viscosity in vivo and the endothelial surface layer
    A R Pries
    Charite Berlin, Dept of Physiology, Arnimallee 22, D 14195 Berlin, Germany
    Am J Physiol Heart Circ Physiol 289:H2657-64. 2005
    ..These results show that flow resistance in vivo can be explained by in vitro blood viscosity and the presence of an ESL and indicate the rheologically effective thickness of the ESL in microvessels...
  12. ncbi 3-D numerical simulation of blood flow through models of the human aorta
    L Morris
    Centre for Applied Biomedical Engineering Research, Dept Mechanical and Aeronautical Eng and Material and Surface Science Institute, University of Limerick, Castletroy, Limerick, Ireland
    J Biomech Eng 127:767-75. 2005
    ..Flow patterns obtained from transient 3-D computational fluid dynamics are influenced by different reconstruction methods and the pulsatility of the flow. Caution is required when analyzing models based on CT scans...
  13. ncbi Wall stress analysis in small asymptomatic, symptomatic and ruptured abdominal aortic aneurysms
    M Truijers
    Department of Vascular Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Vasc Endovasc Surg 33:401-7. 2007
    ..To evaluate the potential of wall stress analysis for the identification of abdominal aortic aneurysm (AAA) at elevated risk of rupture in spite of small diameter...
  14. pmc A mathematical treatment of integrated Ca dynamics within the ventricular myocyte
    Thomas R Shannon
    Department of Molecular Biophysics and Physiology, Rush University, Chicago, Illinois, USA
    Biophys J 87:3351-71. 2004
    ..We conclude that this model is more robust than many previously existing models and reproduces many experimental results using parameters based largely on experimental measurements in myocytes...
  15. ncbi Computer model of action potential of mouse ventricular myocytes
    Vladimir E Bondarenko
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214 3078, USA
    Am J Physiol Heart Circ Physiol 287:H1378-403. 2004
    ..The attribution of putative molecular bases for several of the component currents enables our mouse model to be used to simulate the behavior of genetically modified transgenic mice...
  16. pmc Spiral waves in two-dimensional models of ventricular muscle: formation of a stationary core
    J Beaumont
    Department of Pharmacology, SUNY Health Science Center at Syracuse, Syracuse, New York 13210 USA
    Biophys J 75:1-14. 1998
    ..As such, the results set the stage for an understanding of functional reentry in terms of ionic mechanisms...
  17. pmc Cardiac resynchronization: insight from experimental and computational models
    R C P Kerckhoffs
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Prog Biophys Mol Biol 97:543-61. 2008
    ..In this paper, we focus on to what extent animal experiments and mathematical models can help in order to understand the pathophysiology of asynchrony to further improve CRT...
  18. ncbi Blood flow and structure interactions in a stented abdominal aortic aneurysm model
    Zhonghua Li
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, 3198 Broughton Hall, Raleigh, NC 27695 7910, USA
    Med Eng Phys 27:369-82. 2005
    ..The time-varying drag force on the EVG exerted by physiological blood flow is unavoidable, where for patients with severe hypertension the risk of EVG migration is very high...
  19. ncbi Unsteady and three-dimensional simulation of blood flow in the human aortic arch
    N Shahcheraghi
    Department of Mechanical and Aeronautical Engineering, Institute for Theoretical Dynamics, University of California, Davis 95616, USA
    J Biomech Eng 124:378-87. 2002
    ..Comparison of our numerical results with the localization of early atherosclerotic lesions broadly suggests preferential development of these lesions in regions of extrema (either maxima or minima) in wall shear stress and pressure...
  20. pmc Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation
    Colleen E Clancy
    Dept of Physiology and Biophysics, Insitute for Computational Biomedicine, Weill Medical College of Cornell Univeristy, 1300 York Ave, LC 501E, New York, NY 10021, USA
    Am J Physiol Heart Circ Physiol 292:H66-75. 2007
    ..The simulations also suggest that inactivation state block by lidocaine is less effective in restoring normal repolarization and adversely suppresses peak Na(+) current...
  21. ncbi Shear stress biology of the endothelium
    Peter F Davies
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Ann Biomed Eng 33:1714-8. 2005
    ....
  22. ncbi FEM analysis of predicting electrode-myocardium contact from RF cardiac catheter ablation system impedance
    Hong Cao
    Department of Electrical and Computer Engineering, University of Wisconsin, Madison 53706, USA
    IEEE Trans Biomed Eng 49:520-6. 2002
    ..The FEM result of resistance versus catheter penetration depth matches well with our experimental data...
  23. ncbi Role of gap junctions in the propagation of the cardiac action potential
    Stephan Rohr
    Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Cardiovasc Res 62:309-22. 2004
    ..Whereas computer simulations show the feasibility of conduction in the absence of gap junctional coupling, a definite answer to this question must await further investigations into the biophysical properties of the intercalated disc...
  24. ncbi Single-beat estimation of end-systolic elastance using bilinearly approximated time-varying elastance curve
    T Shishido
    Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka, Japan
    Circulation 102:1983-9. 2000
    ....
  25. ncbi Measurement of myocardial frequency offsets during first pass of a gadolinium-based contrast agent in perfusion studies
    Pedro Ferreira
    National Heart and Lung Institute, Imperial College, London, UK
    Magn Reson Med 60:860-70. 2008
    ..However, when added to other sources of off-resonance it can cause dark rims in particular regions of the myocardium wall in balanced-SSFP sequences...
  26. ncbi Electromechanical model of excitable tissue to study reentrant cardiac arrhythmias
    Martyn P Nash
    Bioengineering Institute and Department of Engineering Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Prog Biophys Mol Biol 85:501-22. 2004
    ..We show that tissue mechanics significantly contributes to the dynamics of electrical propagation, and that a coupled electromechanical approach should be pursued in future electrophysiological modelling studies...
  27. pmc Effects of premature stimulation on HERG K(+) channels
    Y Lu
    Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK
    J Physiol 537:843-51. 2001
    ..6. These properties of HERG K(+) channels may help to suppress arrhythmias initiated by early afterdepolarizations and premature beats in the ventricles, Purkinje fibres or atria...
  28. pmc Drift and breakup of spiral waves in reaction-diffusion-mechanics systems
    A V Panfilov
    Department of Theoretical Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands
    Proc Natl Acad Sci U S A 104:7922-6. 2007
    ..We study mechanisms of these effects and discuss their applicability to the theory of cardiac arrhythmias. Overall, we demonstrate the importance of RD-mechanics systems for mathematics applied to life sciences...
  29. ncbi Structural adaptation of microvascular networks: functional roles of adaptive responses
    A R Pries
    Department of Physiology, Freie Universitat Berlin, D 14195 Berlin, Germany
    Am J Physiol Heart Circ Physiol 281:H1015-25. 2001
    ..In summary, the distribution of vessel diameters generated by the simulated adaptive process allows the network to meet the functional demands of tissue while avoiding excessive viscous energy dissipation...
  30. ncbi Determination of wave speed and wave separation in the arteries
    A W Khir
    Physiological Flow Studies Group, Department of Biological and Medical Systems, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    J Biomech 34:1145-55. 2001
    ..In cases where reflected waves are prominent, this separation of waves can help clarify the pattern of waves in the arteries throughout the cardiac cycle...
  31. ncbi A comparative study of aortic wall stress using finite element analysis for ruptured and non-ruptured abdominal aortic aneurysms
    A K Venkatasubramaniam
    Academic Vascular Unit, Vascular Laboratory, Alderson House, Hull Royal Infirmary, Hull, East Yorkshire HU3 2JZ, UK
    Eur J Vasc Endovasc Surg 28:168-76. 2004
    ..5 cm without rupturing. Hence the need to predict the risk of rupture on an individual patient basis is important. This study aims to calculate and compare wall stress in ruptured and non-ruptured AAA...
  32. ncbi Computational tools for modeling electrical activity in cardiac tissue
    Edward J Vigmond
    Department of Electrical and Computer Engineering, University of Calgary, Alberta, Canada
    J Electrocardiol 36:69-74. 2003
    ..Performance results are given for a large-scale simulation which utilized a comprehensive membrane ionic current description...
  33. pmc Coupling of a 3D finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulation
    Roy C P Kerckhoffs
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Ann Biomed Eng 35:1-18. 2007
    ..The coupling method allows for simulations of multiple cardiac cycles for normal and pathophysiology, encompassing levels from cell to system...
  34. ncbi Relaxation-systolic pressure relation. A load-independent assessment of left ventricular contractility
    T C Gillebert
    Cardiovascular Research Unit Department of Experimental Surgery, University of Antwerp, Belgium
    Circulation 95:745-52. 1997
    ..Assessment of contractility with systolic LVP-relaxation relation is precise and load independent and can be performed with the sole use of a high-fidelity pressure gauge positioned in the left ventricular cavity...
  35. ncbi A dynamical model for generating synthetic electrocardiogram signals
    Patrick E McSharry
    Department of Engineering Science, University of Oxford, Parks Road, Oxford OX1 3PJ, UK
    IEEE Trans Biomed Eng 50:289-94. 2003
    ..This model may be employed to assess biomedical signal processing techniques which are used to compute clinical statistics from the ECG...
  36. ncbi Analysis of blood flow in the entire coronary arterial tree
    N Mittal
    Dept of Biomedical Engineering, Univ of California, Irvine, 204 Rockwell Engineering Center, Irvine, CA 92697 2715, USA
    Am J Physiol Heart Circ Physiol 289:H439-46. 2005
    ..The model of normal hearts will serve as a physiological reference state. Pathological states can then be studied in relation to changes in model parameters that alter coronary perfusion...
  37. ncbi Towards a noninvasive method for determination of patient-specific wall strength distribution in abdominal aortic aneurysms
    Jonathan P Vande Geest
    Department of Surgery, Division of Vascular Surgery, Pittsburgh, PA 15219, USA
    Ann Biomed Eng 34:1098-106. 2006
    ..Coupling this model with our stress analysis technique may provide a more accurate means to estimate patient-specific rupture potential of AAA...
  38. ncbi Dynamical and cellular electrophysiological mechanisms of ECG changes during ischaemia
    O V Aslanidi
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    J Theor Biol 237:369-81. 2005
    ..These results complement simulations of the effects of cardiac geometry on the ECG, and dissect spatio-temporal and cellular electrophysiological mechanisms of ST depression seen in sub-endocardial ischaemia...
  39. ncbi On the passive cardiac conductivity
    Jeroen G Stinstra
    Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT 84112 5000, USA
    Ann Biomed Eng 33:1743-51. 2005
    ..06 S/m (transverse). The latter values are within the range of measured values reported in literature. Furthermore, we anticipate that this method can be used to simulate pathological conditions for which measured data is far more sparse...
  40. ncbi Virtual electrodes and deexcitation: new insights into fibrillation induction and defibrillation
    I R Efimov
    Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Cardiovasc Electrophysiol 11:339-53. 2000
    ..In addition, deexcitation can lead to rapid propagation through newly excitable regions, resulting in the elimination of excitable gaps soon after the shock and causing defibrillation to succeed...
  41. ncbi Shape optimization in steady blood flow: a numerical study of non-Newtonian effects
    Feby Abraham
    Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Comput Methods Biomech Biomed Engin 8:127-37. 2005
    ..For this problem we study the influence of the inflow velocity, and thus the shear rate. Furthermore, we introduce an additional factor in the form of a geometric parameter, and study its effect on the optimal shape obtained...
  42. ncbi Alterations in wall shear stress predict sites of neointimal hyperplasia after stent implantation in rabbit iliac arteries
    John F LaDisa
    Department of Pediatric Cardiology, Stanford University, Stanford, California, USA
    Am J Physiol Heart Circ Physiol 288:H2465-75. 2005
    ..This NH abolished spatial disparity in distributions of WSS. The results suggest that stents may introduce spatial alterations in WSS that modulate NH in vivo...
  43. ncbi Agent-based simulation of notch-mediated tip cell selection in angiogenic sprout initialisation
    Katie Bentley
    Biomolecular Modelling Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    J Theor Biol 250:25-36. 2008
    ....
  44. ncbi A simulated dye method for flow visualization with a computational model for blood flow
    T Kim
    Department of Mathematics, University of California, One Shields Avenue, Davis, CA 95616, USA
    J Biomech 37:1125-36. 2004
    ..Moreover, this method could be useful in investigating the influence of flow and geometry on the local introduction of medication...
  45. ncbi The enigma of Mayer waves: Facts and models
    Claude Julien
    Laboratoire de Physiologie, Faculte de Pharmacie, 8, avenue Rockefeller, Universite Claude Bernard Lyon 1, Lyon 69373 Cedex 08, France
    Cardiovasc Res 70:12-21. 2006
    ..Within this frame, the amplitude of Mayer waves would be determined both by the strength of the triggering perturbations and the sensitivity of the sympathetic component of the baroreceptor reflex...
  46. ncbi Flow-induced wall shear stress in abdominal aortic aneurysms: Part I--steady flow hemodynamics
    Ender A Finol
    Mechanical Engineering, Biomedical and Health Engineering, and institute for Complex Engineered Systems, Carnegie Mellon University, Pittsburgh, PA, USA
    Comput Methods Biomech Biomed Engin 5:309-18. 2002
    ..The temporal distribution of hemodynamic stresses in pulsatile flow and their physical implications in AAA rupture are discussed in Part II of this paper...
  47. ncbi Scaling laws of vascular trees: of form and function
    Ghassan S Kassab
    Dept of Biomedical Engineering, Univ of California, Irvine, 204 Rockwell Engineering Ctr, Irvine, CA 92697 2715, USA
    Am J Physiol Heart Circ Physiol 290:H894-903. 2006
    ..The present study reveals the similarity of nature's scaling laws that dictate the design of various vascular trees and the underlying physical and physiological principles...
  48. ncbi The effect of vagally induced dispersion of action potential duration on atrial arrhythmogenesis
    Edward J Vigmond
    Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada
    Heart Rhythm 1:334-44. 2004
    ..The purpose of this study is to ascertain the effects of spatially variable ACh distributions on arrhythmogenesis in a morphologically realistic computer model of canine atria...
  49. ncbi From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I
    Morteza Naghavi
    The Center for Vulnerable Plaque Research, University of Texas Houston, The Texas Heart Institute, and President Bush Center for Cardiovascular Health, Memorial Hermann Hospital, Houston, USA
    Circulation 108:1664-72. 2003
    ..We encourage healthcare policy makers to promote translational research for screening and treatment of vulnerable patients...
  50. ncbi Pulsatile flow in fusiform models of abdoiminal aortic aneurysms: flow fields, velocity patterns and flow-induced wall stresses
    Robert A Peattie
    Department of Chemical Engineering, Oregon State University, Corvallis, OR 97331, USA
    J Biomech Eng 126:438-46. 2004
    ..Concomitantly, increased turbulence may contribute significantly to wall stress magnitude and thereby to risk of rupture...
  51. ncbi Factors influencing blood flow patterns in the human right coronary artery
    J G Myers
    Department of Mechanical and Industrial Engineering, University of Toronto, Ontario, Canada
    Ann Biomed Eng 29:109-20. 2001
    ....
  52. ncbi Staged growth of optimized arterial model trees
    R Karch
    Department of Medical Computer Sciences, University of Vienna, Austria
    Ann Biomed Eng 28:495-511. 2000
    ....
  53. ncbi Voronoi polyhedra analysis of optimized arterial tree models
    Rudolf Karch
    Department of Medical Computer Sciences, University of Vienna, Spitalgasse 23, A 1090 Wien, Austria
    Ann Biomed Eng 31:548-63. 2003
    ..77 +/- 0.01 for arterial cross-sectional area. Setting terminal flows proportional to the associated VP volumes during tree construction yields a relative dispersion of terminal flows of 37% and a coefficient of skewness of 1.12...
  54. ncbi Effects of elastic property of the wall on flow characteristics through arterial stenoses
    M S Moayeri
    Department of Mechanical Engineering, Shiraz University, Shiraz, Iran
    J Biomech 36:525-35. 2003
    ..The results indicate that deformability of the wall causes an increase in the time average of pressure drop, but a decrease in the maximum wall shear stress. Displacement and stress distributions in the wall are presented...
  55. pmc Influence of dynamic gap junction resistance on impulse propagation in ventricular myocardium: a computer simulation study
    A P Henriquez
    Microelectronics Center of North Carolina, North Carolina Supercomputing Center, Research Triangle Park, North Carolina 27709, USA
    Biophys J 81:2112-21. 2001
    ..The results suggest that the dynamics of the gap junction enhance cellular decoupling as a possible protective mechanism of isolating injured cells from their neighbors...
  56. ncbi Generation of an anatomically based geometric coronary model
    N P Smith
    Department of Engineering Science, University of Auckland, New Zealand
    Ann Biomed Eng 28:14-25. 2000
    ..The local finite element coordinates of the coronary nodes within the ventricular mesh are calculated such that the coronary geometry can be recalculated within a deformed ventricular mesh...
  57. ncbi Effects of cardiac motion on right coronary artery hemodynamics
    Dehong Zeng
    Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada
    Ann Biomed Eng 31:420-9. 2003
    ..The hemodynamic effects of RCA motion can, therefore, be ignored as a first approximation in modeling studies...
  58. ncbi Cholinergic atrial fibrillation in a computer model of a two-dimensional sheet of canine atrial cells with realistic ionic properties
    James Kneller
    Research Center and Department of Medicine, Montreal Heart Institute and University of Montreal, Quebec, Canada
    Circ Res 90:E73-87. 2002
    ..The full text of this article is available at http://www.circresaha.org...
  59. ncbi Branching tree model with fractal vascular resistance explains fractal perfusion heterogeneity
    M Marxen
    Department of Medical Biophysics, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, S605 2075 Bayview Avenue, Toronto, Ontario, Canada, M4N 3M5
    Am J Physiol Heart Circ Physiol 284:H1848-57. 2003
    ..The model allows a physiological interpretation of the measured fractal parameters, which could in turn be used to characterize vascular morphology and function...
  60. ncbi Flow-induced wall shear stress in abdominal aortic aneurysms: Part II--pulsatile flow hemodynamics
    Ender A Finol
    Mechanical Engineering, Biomedical and Health Engineering, and institute for Complex Engineered Systems, Carnegie Mellon University, Pittsburgh, PA, USA
    Comput Methods Biomech Biomed Engin 5:319-28. 2002
    ..A comparison between numerical predictions for steady and pulsatile flow is presented, illustrating the importance of considering time-dependent flow for the evaluation of hemodynamic indicators...
  61. ncbi An electric field mechanism for transmission of excitation between myocardial cells
    Nicholas Sperelakis
    Circ Res 91:985-7. 2002
  62. ncbi The effect of asymmetry in abdominal aortic aneurysms under physiologically realistic pulsatile flow conditions
    E A Finol
    Institute for Complex Engineered Systems, Faculty, Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    J Biomech Eng 125:207-17. 2003
    ..The effect of asymmetry in hypothetically shaped AAAs is to increase the maximum wall shear stress at peak flow and to induce the appearance of secondary flows in late diastole...
  63. ncbi Mass transport in arteries and the localization of atherosclerosis
    John M Tarbell
    The City College of New York CUNY, New York, New York 10031, USA
    Annu Rev Biomed Eng 5:79-118. 2003
    ..Further study of these mechanisms may contribute to the development of therapeutic strategies for atherosclerotic diseases...
  64. ncbi How to measure baroreflex sensitivity: from the cardiovascular laboratory to daily life
    G Parati
    Istituto Scientifico Ospedale S Luca, Istituto Auxologico Italiano, Milan
    J Hypertens 18:7-19. 2000
    ..This review will briefly survey the methods most widely used to assess baroreflex function in humans, in the laboratory and in daily life...
  65. ncbi Fast tracking of cardiac motion using 3D-HARP
    Li Pan
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, 601 N Caroline St JHOC 4240, Baltimore, MD 21287, USA
    IEEE Trans Biomed Eng 52:1425-35. 2005
    ..8605 and r2 = 0.8645, respectively. The total time required for tracking 3-D cardiac motion is approximately 10 min in a 9 timeframe tagged MRI dataset and has the potential to be much faster...
  66. ncbi Nonsustained reentry following successive stimulation of cardiac tissue through a unipolar electrode
    B J Roth
    Dept of Physics and Astronomy Vanderbilt University, Nashville, TN 37235, USA
    J Cardiovasc Electrophysiol 8:768-78. 1997
    ..Using numerical simulations, we predict that nonsustained reentry occurs following a strong, premature stimulus through a unipolar electrode...
  67. pmc Local maximal stress hypothesis and computational plaque vulnerability index for atherosclerotic plaque assessment
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Ann Biomed Eng 33:1789-801. 2005
    ..Large-scale and long-term patient studies are needed to further validate our findings for more accurate quantitative plaque vulnerability assessment...
  68. ncbi Blood flow in abdominal aortic aneurysms: pulsatile flow hemodynamics
    E A Finol
    Mechanical Engineering, Biomedical and Health Engineering, and institute for Complex Engineered Systems, Carnegie Mellon University, Pittsburgh, PA 15213-3890, USA
    J Biomech Eng 123:474-84. 2001
    ..A comparison between predictions for steady and pulsatile flow is presented, illustrating the importance of considering time-dependent flow for the evaluation of hemodynamic indicators...
  69. ncbi Modulatory effect of calmodulin-dependent kinase II (CaMKII) on sarcoplasmic reticulum Ca2+ handling and interval-force relations: a modelling study
    Gentaro Iribe
    Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    Philos Trans A Math Phys Eng Sci 364:1107-33. 2006
    ....
  70. ncbi A patient-specific computational model of fluid-structure interaction in abdominal aortic aneurysms
    B J B M Wolters
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    Med Eng Phys 27:871-83. 2005
    ..The mechanical quantities computed in these simulations need to be validated in a clinical setting, after which they could be included in clinical trials in search of risk factors for AAA rupture...
  71. pmc Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte
    Joseph L Greenstein
    The Center for Cardiovascular Bioinformatics and Modeling and The Whitaker Biomedical Engineering Institute, The Johns Hopkins University Whiting School of Engineering and School of Medicine, Baltimore, Maryland, USA
    Biophys J 90:77-91. 2006
    ..We also demonstrate mechanisms by which alterations in the early repolarization phase of the action potential, resulting from reduction of the transient outward potassium current, alters properties of EC coupling...
  72. ncbi Analysis of biomechanical factors affecting stent-graft migration in an abdominal aortic aneurysm model
    Z Li
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA
    J Biomech 39:2264-73. 2006
    ..A comprehensive FSI analysis of the coupled SG-AAA dynamics provides physical insight for evaluating the luminal hemodynamics, and maximum AAA-stresses as well as biomechanical factors leading potentially to SG migration...
  73. ncbi Experimental verification of theoretical predictions concerning the optimum defibrillation waveform
    Robert A Malkin
    Biomedical Engineering, Duke University, Durham, NC 27708, USA
    IEEE Trans Biomed Eng 53:1492-8. 2006
    ..We conclude that the theoretical framework adequately explains the mechanism by which the defibrillation waveform affects efficacy for monophasic waveforms and, in at least one aspect, biphasic waveforms...
  74. ncbi Structural analysis and magnetic resonance imaging predict plaque vulnerability: a study comparing symptomatic and asymptomatic individuals
    Zhi Yong Li
    University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
    J Vasc Surg 45:768-75. 2007
    ..We used finite element analysis based on in vivo magnetic resonance imaging (MRI) to simulate the stress distributions within plaques of asymptomatic and symptomatic individuals...
  75. ncbi Stent expansion in curved vessel and their interactions: a finite element analysis
    Wei Wu
    Department of Materials Engineering, Dalian University of Technology, No 2, LingGong Road, Dalian, Liaoning 116024, China
    J Biomech 40:2580-5. 2007
    ..This FEM provides a tool to study mechanisms of stents in curved vessels and can improve new stent designs especially for tortuous vessels...
  76. ncbi Accessing heart dynamics to estimate durations of heart sounds
    Vivek Nigam
    Electrical and Computer Engineering Department, University of Illinois at Chicago, M C 154, 851 South Morgan, 60607, USA
    Physiol Meas 26:1005-18. 2005
    ..Complexity-based segmentation is invariant to amplitude and frequency variations of the heart sound and yields better time gates for heart sounds...
  77. ncbi Solving the cardiac bidomain equations for discontinuous conductivities
    Travis M Austin
    Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland 1001, New Zealand
    IEEE Trans Biomed Eng 53:1265-72. 2006
    ..Also, for the problems examined, it will be shown that a direct usage of conventional multigrid leads to faster simulations than an indirect usage of conventional multigrid as a preconditioner unless there are sharp discontinuities...
  78. ncbi Pulsatile blood flow in the entire coronary arterial tree: theory and experiment
    Yunlong Huo
    Department of Biomedical Engineering, University of California, Irvine, USA
    Am J Physiol Heart Circ Physiol 291:H1074-87. 2006
    ..The present model will serve to quantitatively test various hypotheses in the coronary circulation under pulsatile flow conditions...
  79. ncbi A finite element model of the human left ventricular systole
    F Dorri
    Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse 35, CH 8092, Zurich, Switzerland
    Comput Methods Biomech Biomed Engin 9:319-41. 2006
    ..We therefore, expect that the measurement of systolic deformation might provide useful diagnostic information...
  80. ncbi Active myocyte shortening during the 'isovolumetric relaxation' phase of diastole is responsible for ventricular suction; 'systolic ventricular filling'
    Gerald D Buckberg
    Option on Bioengineering, California Institute of Technology, Pasadena, CA, USA
    Eur J Cardiothorac Surg 29:S98-106. 2006
    ....
  81. ncbi A theoretical model of enlarging intracranial fusiform aneurysms
    S Baek
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843 3120, USA
    J Biomech Eng 128:142-9. 2006
    ..Such information can better direct the requisite histopathological examinations, particularly on the need to quantify collagen orientations as a function of lesion geometry...
  82. ncbi Physiological basis of clinically used coronary hemodynamic indices
    Jos A E Spaan
    Department of Medical Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 113:446-55. 2006
    ..We conclude that traditional hemodynamic indices are valuable for clinical decision making but that clinical studies of coronary physiology will benefit greatly from combined measurements of coronary flow or velocity and pressure...
  83. ncbi Peak vs. total reactive hyperemia: which determines the magnitude of flow-mediated dilation?
    Kyra E Pyke
    Human Vascular Control Laboratory, School of Kinesiology and Health Studies and Department of Physiology, Queen s University, Kingston, Ontario, Canada
    J Appl Physiol 102:1510-9. 2007
    ..07). We conclude that the shear stimulus AUC, not the peak itself, is the critical determinant of the peak FMD response. This indicates AUC as the best method of quantifying reactive hyperemia shear stimulus for %FMD normalization...
  84. ncbi The effect of conductivity on ST-segment epicardial potentials arising from subendocardial ischemia
    Bruce Hopenfeld
    The Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah 84112 5000, USA
    Ann Biomed Eng 33:751-63. 2005
    ..The magnitude of the depression is a function of the bidomain conductivity values...
  85. ncbi The non-circular shape of FloWatch-PAB prevents the need for pulmonary artery reconstruction after banding. Computational fluid dynamics and clinical correlations
    Antonio F Corno
    Alder Hey Royal Children Hospital, Eaton Road, Liverpool, L12 2AP, England, UK
    Eur J Cardiothorac Surg 29:93-9. 2006
    ..To evaluate the differences between non-circular shape of FloWatch-PAB and conventional pulmonary artery (PA) banding...
  86. ncbi Evaluation of coronary stents in vitro with CT angiography: effect of stent diameter, convolution kernel, and vessel orientation to the z-axis
    Shigeru Suzuki
    Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan
    Circ J 69:1124-31. 2005
    ..The aims of the present study were to assess the effect of the stent diameter, convolution kernel, and vessel orientation to the z-axis on the evaluation of coronary stents, in vitro with computed tomography (CT) angiography...
  87. ncbi Prognosis after aortic valve replacement with the Carpentier-Edwards pericardial valve: use of microsimulation
    John P A Puvimanasinghe
    Department of Cardiothoracic Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Thorac Surg 80:825-31. 2005
    ..We used microsimulation to calculate the long-term outcome of any given patient after aortic valve replacement with the Carpentier-Edwards pericardial valve...
  88. ncbi 3D MRI-based multicomponent FSI models for atherosclerotic plaques
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
    Ann Biomed Eng 32:947-60. 2004
    ..Large-scale patient studies are needed to validate the computational findings for possible plaque vulnerability assessment and rupture predictions...
  89. ncbi Mapping preconditioning's signaling pathways: an engineering approach
    James M Downey
    Department of Physiology and Medicine, University of South Alabama, Mobile, AL 36688, USA
    Ann N Y Acad Sci 1123:187-96. 2008
    ..The proposed signaling maps reveal many points at which drugs can trigger the protected phenotype...
  90. ncbi PIV-measured versus CFD-predicted flow dynamics in anatomically realistic cerebral aneurysm models
    Matthew D Ford
    Imaging Research Laboratories, Robarts Research Institute, London, Canada N6A 5K8
    J Biomech Eng 130:021015. 2008
    ..Nevertheless, given the various modeling assumptions, this does not prove that they are mimicking the actual in vivo hemodynamics, and so validations against in vivo data are encouraged whenever possible...
  91. pmc Initiation of embryonic cardiac pacemaker activity by inositol 1,4,5-trisphosphate-dependent calcium signaling
    Annabelle Mery
    CRBM, Centre National de la Recherche Scientifique FRE2593, 34293 Montpellier, France
    Mol Biol Cell 16:2414-23. 2005
    ..We show that InsP3-dependent shuttle of free Ca2+ in and out of the endoplasmic reticulum is essential for a proper generation of pacemaker activity during early cardiogenesis and fetal life...
  92. ncbi Individual and combined effects of shear stress magnitude and spatial gradient on endothelial cell gene expression
    Jeffrey A LaMack
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    Am J Physiol Heart Circ Physiol 293:H2853-9. 2007
    ..These results support the notion that vascular endothelial cells are able to sense shear gradient and magnitude independently...
  93. ncbi Structure and torsion of the normal and situs inversus totalis cardiac left ventricle. I. Experimental data in humans
    Tammo Delhaas
    Dept of Physiology and Pediatrics, Cardiovascular Research Institute Maastricht, Maastricht Univ, Maastricht, The Netherlands
    Am J Physiol Heart Circ Physiol 295:H197-201. 2008
    ..This provides a unique possibility to study regulatory mechanisms for myocardial fiber orientation and mechanical load, which has been dealt with in the companion paper by Kroon et al...
  94. ncbi Simultaneous determination of wave speed and arrival time of reflected waves using the pressure-velocity loop
    A W Khir
    Brunel Institute for Bioengineering and The School of Engineering and Design, Brunel University, Uxbridge, Middlesex, UB8 3PH, UK
    Med Biol Eng Comput 45:1201-10. 2007
    ..83, P < 0.001). We conclude that the new technique described in this paper offers a convenient and objective method for detecting Tr, and allows for the dynamic determination of wave speed and Tr, simultaneously...
  95. ncbi Simulating transient ventricular interaction using a minimal cardiovascular system model
    Bram W Smith
    Centre for Model Based Medical Decision Support, Niels Jernes Vej 14, 4 311 Aalborg University, Aalborg DK 9220, Denmark
    Physiol Meas 27:165-79. 2006
    ..This study proves the value of this modelling method to be used in conjunction with experimental data for delineating and understanding the factors that contribute to ventricular dynamics...
  96. ncbi Cardiovascular stent design and vessel stresses: a finite element analysis
    C Lally
    Centre for Bioengineering, Department of Mechanical Engineering, Trinity College, Dublin 2, Ireland
    J Biomech 38:1574-81. 2005
    ..Therefore, the testing methodology outlined here is proposed as a pre-clinical testing tool, which could be used to compare and contrast existing stent designs and to develop novel stent designs...
  97. ncbi Optimizing defibrillation waveforms for ICDs
    Mark W Kroll
    Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA
    J Interv Card Electrophysiol 18:247-63. 2007
    ..It is unlikely that substantial improvement in defibrillation efficacy will be achieved without radical changes in waveform design...
  98. ncbi Experimental studies of the effects of abnormal venous valves on fluid flow
    C D Buescher
    Department of Chemical Engineering, Texas Tech University, Lubbock, Texas 79409, USA
    Biotechnol Prog 21:938-45. 2005
    ..The results also indicate that increases in the gap width, which serve to increase the degree of imperfect wall attachment, have less effect on retrograde mass flow rate in valves with deeper sinuses...
  99. pmc Modeling of spatial metabolite distributions in the cardiac sarcomere
    Vitaly A Selivanov
    Departamento de Bioquimica i Biologia Molecular, Facultat de Quimica and CERQT at Parc Cientific de Barcelona, Barcelona, Catalunya, Spain
    Biophys J 92:3492-500. 2007
    ..The diffusion barriers thus defined explain the coexistence of pathological energy deficit with almost normal average ATP levels...
  100. ncbi Computational study of fluid mechanical disturbance induced by endovascular stents
    Taewon Seo
    Department of Mechanical and Aeronautical Engineering, University of California, Davis, CA 95616, USA
    Ann Biomed Eng 33:444-56. 2005
    ..These results provide an understanding of the flow physics in the vicinity of stents and suggest strategies for stent design optimization to minimize flow disturbance...
  101. ncbi Stepped defibrillation waveform is substantially more efficient than the 50/50% tilt biphasic
    Karlheinz Seidl
    Herzzentrum, Ludwigshafen, Germany
    Heart Rhythm 3:1406-11. 2006
    ..The stepped waveform has three parts: the first portion is positive with two capacitors in parallel, the second is positive with the capacitors in series, and the last portion is negative, also with the capacitors in series...

Research Grants15

  1. Role of Nitric Oxide and Cyclic GMP in Stem Cells
    David G Gorenstein; Fiscal Year: 2010
    ..The function of these stem cells and differentiated cells will also be examined in several cardiovascular models. This should be extremely valuable information for future clinical studies by others and us for the ..
  2. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2008
    ..4) To study the properties and repolarization-dependent mechanisms of arrhythmias in the remodeled myocardium post myocardial infarction. ..
  3. INVERSE AND FORWARD PROBLEMS IN ELECTROCARDIOGRAPHY
    Yoram Rudy; Fiscal Year: 2007
    ..abstract_text> ..
  4. Controlled Reperfusion for Whole Body Ischemic Injury
    Gerald Buckberg; Fiscal Year: 2005
    ..If this novel method of management is correct, the scheme of diagnosis and management of this almost always fatal cardiac arrest complex will change markedly. ..
  5. Noninvasive Quantification of the Resistance Baroeflex
    Ramakrishna Mukkamala; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  6. Continuous Cardiac Output & Filling Pressure Monitoring
    Ramakrishna Mukkamala; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. Analysis of Large-Scale Biochemical Systems
    DANIEL BEARD; Fiscal Year: 2007
    ..In addition, the computational tools that are developed by this research program will be disseminated through a partnership with a software company. [unreadable] [unreadable] [unreadable]..
  8. A Novel Polymeric Trileaflet Heart Valve Prosthesis
    SCOTT CORBETT; Fiscal Year: 2008
    ..valves that improves upon the shortcomings of existing replacement valves, reduces the cost burden on the health care system and improves the survival rate of patients with heart valve prostheses [unreadable] [unreadable] [unreadable]..
  9. Platelet adhesion in experimental colitis
    D Granger; Fiscal Year: 2008
    ..The proposed work should result in a better understanding of the nature and contribution of platelet activation and adhesion to the pathogenesis of IBD. [unreadable] [unreadable] [unreadable]..
  10. ENDOTHELIAL GENE REGULATION BY BIOMECHANICAL FORCES
    MICHAEL GIMBRONE; Fiscal Year: 2003
    ....
  11. MOEMS device for fluorescence spectroscopy of tissues and cells
    Laura Marcu; Fiscal Year: 2006
    ..The device will widely be applied to various biomedical instruments that require wavelength differentiation and selection. ..
  12. INTERCELLULAR COORDINATION OF BLOOD FLOW CONTROL
    STEVEN SEGAL; Fiscal Year: 2004
    ....
  13. Transducer for indirect blood pressure& O2 saturation
    Leslie Geddes; Fiscal Year: 2005
    ..The neonatologist, the premature infant physician and the small-infant pediatrician have no single instrument that provides all of these vital signs. ..
  14. Regional Dysfunction by MRI in Incident Heart Failure
    Joao Lima; Fiscal Year: 2009
    ..These findings will be pivotal to the design of future strategies to forestall progressive myocardial dysfunction and prevent the development of heart failure. ..
  15. Couple Therapy and Pharmacotherapy for Major Depression
    WAYNE DENTON; Fiscal Year: 2007
    ..abstract_text> ..