theoretical models

Summary

Summary: Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.

Top Publications

  1. pmc Heterogeneities in the transmission of infectious agents: implications for the design of control programs
    M E Woolhouse
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, United Kingdom
    Proc Natl Acad Sci U S A 94:338-42. 1997
  2. ncbi Epidemic spreading in scale-free networks
    R Pastor-Satorras
    , , Barcelona, Spain
    Phys Rev Lett 86:3200-3. 2001
  3. ncbi Strategies for mitigating an influenza pandemic
    Neil M Ferguson
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Nature 442:448-52. 2006
  4. pmc Intrinsic and extrinsic contributions to stochasticity in gene expression
    Peter S Swain
    Center for Studies in Physics and Biology and Laboratory for Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:12795-800. 2002
  5. pmc Community structure in social and biological networks
    M Girvan
    Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA
    Proc Natl Acad Sci U S A 99:7821-6. 2002
  6. ncbi Extinction risk from climate change
    Chris D Thomas
    Centre for Biodiversity and Conservation, School of Biology, University of Leeds, Leeds LS2 9JT, UK
    Nature 427:145-8. 2004
  7. ncbi Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
    Ting Chao Chou
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Pharmacol Rev 58:621-81. 2006
  8. pmc Social contacts and mixing patterns relevant to the spread of infectious diseases
    Joel Mossong
    Microbiology Unit, Laboratoire National de Santé, Luxembourg, Luxembourg
    PLoS Med 5:e74. 2008
  9. ncbi Exploring complex networks
    S H Strogatz
    Department of Theoretical and Applied Mechanics and Center for Applied Mathematics, Cornell University, Ithaca, New York 14853 1503, USA
    Nature 410:268-76. 2001
  10. pmc Niche tradeoffs, neutrality, and community structure: a stochastic theory of resource competition, invasion, and community assembly
    David Tilman
    Department of Ecology, Evolution, and Behavior, University of Minnesota, 1987 Upper Buford Circle, St Paul, MN 55108, USA
    Proc Natl Acad Sci U S A 101:10854-61. 2004

Detail Information

Publications362 found, 100 shown here

  1. pmc Heterogeneities in the transmission of infectious agents: implications for the design of control programs
    M E Woolhouse
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, United Kingdom
    Proc Natl Acad Sci U S A 94:338-42. 1997
    ....
  2. ncbi Epidemic spreading in scale-free networks
    R Pastor-Satorras
    , , Barcelona, Spain
    Phys Rev Lett 86:3200-3. 2001
    ..This new epidemiological framework rationalizes data of computer viruses and could help in the understanding of other spreading phenomena on communication and social networks...
  3. ncbi Strategies for mitigating an influenza pandemic
    Neil M Ferguson
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Nature 442:448-52. 2006
    ..Estimates of policy effectiveness will change if the characteristics of a future pandemic strain differ substantially from those seen in past pandemics...
  4. pmc Intrinsic and extrinsic contributions to stochasticity in gene expression
    Peter S Swain
    Center for Studies in Physics and Biology and Laboratory for Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:12795-800. 2002
    ..All results are confirmed by stochastic simulation using plausible parameters for Escherichia coli...
  5. pmc Community structure in social and biological networks
    M Girvan
    Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA
    Proc Natl Acad Sci U S A 99:7821-6. 2002
    ..We also apply the method to two networks whose community structure is not well known--a collaboration network and a food web--and find that it detects significant and informative community divisions in both cases...
  6. ncbi Extinction risk from climate change
    Chris D Thomas
    Centre for Biodiversity and Conservation, School of Biology, University of Leeds, Leeds LS2 9JT, UK
    Nature 427:145-8. 2004
    ..These estimates show the importance of rapid implementation of technologies to decrease greenhouse gas emissions and strategies for carbon sequestration...
  7. ncbi Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
    Ting Chao Chou
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Pharmacol Rev 58:621-81. 2006
    ....
  8. pmc Social contacts and mixing patterns relevant to the spread of infectious diseases
    Joel Mossong
    Microbiology Unit, Laboratoire National de Santé, Luxembourg, Luxembourg
    PLoS Med 5:e74. 2008
    ..We conducted a population-based prospective survey of mixing patterns in eight European countries using a common paper-diary methodology...
  9. ncbi Exploring complex networks
    S H Strogatz
    Department of Theoretical and Applied Mechanics and Center for Applied Mathematics, Cornell University, Ithaca, New York 14853 1503, USA
    Nature 410:268-76. 2001
    ..Researchers are only now beginning to unravel the structure and dynamics of complex networks...
  10. pmc Niche tradeoffs, neutrality, and community structure: a stochastic theory of resource competition, invasion, and community assembly
    David Tilman
    Department of Ecology, Evolution, and Behavior, University of Minnesota, 1987 Upper Buford Circle, St Paul, MN 55108, USA
    Proc Natl Acad Sci U S A 101:10854-61. 2004
    ..This prediction provides a potential solution to the invasion paradox, which is the tendency for highly diverse regions to be more heavily invaded...
  11. ncbi Using circuit theory to model connectivity in ecology, evolution, and conservation
    Brad H McRae
    National Center for Ecological Analysis and Synthesis, Santa Barbara, California 93101, USA
    Ecology 89:2712-24. 2008
    ..We provide examples of how circuit models can be used to predict movement patterns and fates of random walkers in complex landscapes and to identify important habitat patches and movement corridors for conservation planning...
  12. ncbi Application of land use regression to estimate long-term concentrations of traffic-related nitrogen oxides and fine particulate matter
    Sarah B Henderson
    School of Occupational and Environmental Hygiene, The University of British Columbia, Vancouver, British Columbia, Canada
    Environ Sci Technol 41:2422-8. 2007
    ..62 and were similar across traffic metrics. Resulting maps show the distribution of NO to be more heterogeneous than that of NO2, supporting the usefulness of this approach for assessing spatial patterns of traffic-related pollution...
  13. ncbi Mathematical models of HIV pathogenesis and treatment
    Dominik Wodarz
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 665, Seattle, WA 98109 1024, USA
    Bioessays 24:1178-87. 2002
    ..Finally, we show how mathematical models can be used to understand correlates of long-term immunological control of HIV, and to design therapy regimes that convert a progressing patient into a state of long-term non-progression...
  14. ncbi Prospects for worldwide tuberculosis control under the WHO DOTS strategy. Directly observed short-course therapy
    C Dye
    Global Tuberculosis Programme, WHO, Geneva, Switzerland
    Lancet 352:1886-91. 1998
    ..WHO advocates the use of directly observed treatment with a short-course drug regimen as part of the DOTS strategy, but the potential effect of this strategy worldwide has not been investigated...
  15. ncbi Realistic distributions of infectious periods in epidemic models: changing patterns of persistence and dynamics
    A L Lloyd
    Program in Theoretical Biology, Institute for Advanced Study, Einstein Drive, Princeton, New Jersey 08540, USA
    Theor Popul Biol 60:59-71. 2001
    ..Since it has a major effect on the central issues of population persistence and dynamics, the results of this study have broad implications for mathematical modellers of a wide range of biological systems...
  16. pmc Empirical evidence for the effect of airline travel on inter-regional influenza spread in the United States
    John S Brownstein
    Children s Hospital Informatics Program at the Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA
    PLoS Med 3:e401. 2006
    ..Here, we assess, with empirical data, the role of airline volume on the yearly inter-regional spread of influenza in the United States...
  17. pmc Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage
    Eric Batchelor
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 30:277-89. 2008
    ....
  18. pmc Hedging against antiviral resistance during the next influenza pandemic using small stockpiles of an alternative chemotherapy
    Joseph T Wu
    Department of Community Medicine and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    PLoS Med 6:e1000085. 2009
    ..We developed a mathematical model to test the hypothesis that a small stockpile of a secondary antiviral drug could be used to mitigate the adverse consequences of the emergence of resistant strains...
  19. pmc Social contact networks for the spread of pandemic influenza in children and teenagers
    Laura M Glass
    Albuquerque Public Schools, Albuquerque, New Mexico, USA
    BMC Public Health 8:61. 2008
    ..We developed a method to characterize the social contact network for the potential transmission of influenza and then applied the method to school aged children and teenagers...
  20. pmc Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals
    Carl T Bergstrom
    Department of Biology, University of Washington, Seattle, WA 98195 1800, USA
    Proc Natl Acad Sci U S A 101:13285-90. 2004
    ..As a consequence, cycling is unlikely to be effective and may even hinder resistance control. These results may explain the limited success reported thus far from clinical trials of antimicrobial cycling...
  21. ncbi A robustness-based approach to systems-oriented drug design
    Hiroaki Kitano
    Sony Computer Science Laboratories Inc, 3 14 13 Higashi Gotanda, Shinagawa, Tokyo 141 0022, Japan
    Nat Rev Drug Discov 6:202-10. 2007
    ....
  22. ncbi DEM: a variational treatment of dynamic systems
    K J Friston
    The Wellcome Department of Imaging Neuroscience, University College London, United Kingdom
    Neuroimage 41:849-85. 2008
    ..Furthermore, it provides for dual and triple inferences on a system's states, parameters and hyperparameters using exactly the same principles. We refer to this approach as dynamic expectation maximisation (DEM)...
  23. pmc Factors that make an infectious disease outbreak controllable
    Christophe Fraser
    Department of Infectious Disease Epidemiology, Imperial College, St Mary s, London W2 1PG, United Kingdom
    Proc Natl Acad Sci U S A 101:6146-51. 2004
    ..Direct estimation of the proportion of asymptomatic and presymptomatic infections is achievable by contact tracing and should be a priority during an outbreak of a novel infectious agent...
  24. ncbi Ecosystem service supply and vulnerability to global change in Europe
    Dagmar Schröter
    Potsdam Institute for Climate Impact Research, 14473 Potsdam, Germany
    Science 310:1333-7. 2005
    ....
  25. pmc Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
    Nick I Markevich
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
    J Cell Biol 164:353-9. 2004
    ..Hence, bistability induced by multisite covalent modification may be a widespread mechanism of the control of protein activity...
  26. ncbi Early therapy for latent tuberculosis infection
    E Ziv
    Department of Medicine, Veterans Affairs Medical Center, San Francisco 94121, USA
    Am J Epidemiol 153:381-5. 2001
    ..Analysis of the model suggests that programs such as contact investigations, which identify and treat persons recently infected with Mycobacterium tuberculosis, may have a substantial effect on controlling tuberculosis epidemics...
  27. ncbi Spherical aberration after laser in situ keratomileusis and photorefractive keratectomy. Clinical results and theoretical models of etiology
    Peter S Hersh
    Institute of Ophthalmology and Visual Science, UMDNJ New Jersey Medical School, Newark, NJ, USA
    J Cataract Refract Surg 29:2096-104. 2003
    ..To assess changes in corneal asphericity after laser refractive surgery and mathematically model possible causes of the changes...
  28. pmc How microbial community composition regulates coral disease development
    Justin Mao-Jones
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York, United States of America
    PLoS Biol 8:e1000345. 2010
    ....
  29. ncbi Vitamins and minerals: a model for safe addition to foods
    Albert Flynn
    University College Cork, Department of Food and Nutritional Sciences, Cork, Ireland
    Eur J Nutr 42:118-30. 2003
    ..However, concerns need to be addressed regarding the potential for unacceptably high intakes, particularly for those people consuming very large amounts of food...
  30. pmc Simulations of inositol phosphate metabolism and its interaction with InsP(3)-mediated calcium release
    Jyoti Mishra
    National Centre for Biological Sciences, GKVK Campus, Bangalore 560065, India
    Biophys J 83:1298-316. 2002
    ..Calcium oscillations produce oscillatory responses in parts of the metabolic network and are in turn temporally modulated by the metabolism of InsP(3)...
  31. pmc Evoked brain responses are generated by feedback loops
    Marta I Garrido
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 104:20961-6. 2007
    ..This is the theoretical cornerstone of most modern theories of perceptual inference and learning...
  32. pmc Oscillations and variability in the p53 system
    Naama Geva-Zatorsky
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Mol Syst Biol 2:2006.0033. 2006
    ..the dynamics and variability of protein circuitry requires accurate measurements in living cells as well as theoretical models. To address this, we employed one of the best-studied protein circuits in human cells, the negative feedback ..
  33. ncbi The theoretical population-level impact of a prophylactic human papilloma virus vaccine
    James P Hughes
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
    Epidemiology 13:631-9. 2002
    ..The ongoing development of a vaccine against human papillomavirus (HPV) raises important questions about the impact of various vaccination strategies...
  34. ncbi Dominant pathways in protein folding
    P Faccioli
    Dipartimento di Fisica Universitá degli Studi di Trento e I N F N, Via Sommarive 14, Povo Trento, I 38050 Italy
    Phys Rev Lett 97:108101. 2006
    ..This completely general method does not require the prior knowledge of any reaction coordinate and is an efficient tool to perform simulations of the entire folding process with available computers...
  35. ncbi Reducing the burden of childhood malaria in Africa: the role of improved
    Maria E Rafael
    RAND Corporation, 1776 Main Street, PO Box 2138, Santa Monica, California 90401 2138, USA
    Nature 444:39-48. 2006
  36. ncbi Transtheoretical model-chronic disease care for obesity in primary care: a randomized trial
    Everett Logue
    Department of Family Practice, Summa Health System, 525 East Market Street, Suite 290, Akron, OH 44309 2090, USA
    Obes Res 13:917-27. 2005
    ..To compare health benefits achieved in a transtheoretical model-chronic disease (TM-CD) minimal intervention for obesity vs. augmented usual care (AUC)...
  37. ncbi Scale-free networks from varying vertex intrinsic fitness
    G Caldarelli
    INFM UdR ROMA1 Dipartimento Fisica, Universita di Roma La Sapienza, Piazzale Aldo Moro 2, Italy
    Phys Rev Lett 89:258702. 2002
    ..e., to be highly connected)...
  38. pmc The nested assembly of plant-animal mutualistic networks
    Jordi Bascompte
    Integrative Ecology Group, Estacion Biologica de Donana, Consejo Superior de Investigaciones Cientificas, Apartado 1056, E 41080 Sevilla, Spain
    Proc Natl Acad Sci U S A 100:9383-7. 2003
    ..Our results indicate a nonrandom pattern of community organization that may be relevant for our understanding of the organization and persistence of biodiversity...
  39. pmc Emissions pathways, climate change, and impacts on California
    Katharine Hayhoe
    ATMOS Research and Consulting, 809 West Colfax Avenue, South Bend, IN 46601, USA
    Proc Natl Acad Sci U S A 101:12422-7. 2004
    ..Although interscenario differences in climate impacts and costs of adaptation emerge mainly in the second half of the century, they are strongly dependent on emissions from preceding decades...
  40. ncbi Containing pandemic influenza with antiviral agents
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Am J Epidemiol 159:623-33. 2004
    ..Targeted antiviral prophylaxis has potential as an effective measure for containing influenza until adequate quantities of vaccine are available...
  41. pmc Efficient generation of feasible pathways for protein conformational transitions
    Moon K Kim
    Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Biophys J 83:1620-30. 2002
    ..We also illustrate how this framework can be used to complement experimental techniques that partially observe protein motions...
  42. ncbi Forks in the road: choices in procedures for designing wildland linkages
    Paul Beier
    School of Forestry and Merriam Powell Center for Environmental Research, Northern Arizona University, Flagstaff, AZ 86011 5018, USA
    Conserv Biol 22:836-51. 2008
    ....
  43. pmc Integrative analysis of cell cycle control in budding yeast
    Katherine C Chen
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 0406, USA
    Mol Biol Cell 15:3841-62. 2004
    ....
  44. ncbi Genomic control, a new approach to genetic-based association studies
    B Devlin
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Theor Popul Biol 60:155-66. 2001
    ..For each study design our goal is to achieve control similar to that obtained for a family-based study, but with the convenience found in a population-based design...
  45. ncbi Altitudinal patterns of tick and host abundance: a potential role for climate change in regulating tick-borne diseases?
    Lucy Gilbert
    Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen, UK
    Oecologia 162:217-25. 2010
    ....
  46. pmc Measures of degeneracy and redundancy in biological networks
    G Tononi
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 96:3257-62. 1999
    ..These measures promise to be useful in characterizing and understanding the functional robustness and adaptability of biological networks...
  47. ncbi New testing strategy to detect early HIV-1 infection for use in incidence estimates and for clinical and prevention purposes
    R S Janssen
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 280:42-8. 1998
    ..Differentiating individuals with early human immunodeficiency virus 1 (HIV-1) infection from those infected for longer periods is difficult but important for estimating HIV incidence and for purposes of clinical care and prevention...
  48. pmc Dynamics of the cell cycle: checkpoints, sizers, and timers
    Zhilin Qu
    Cardiovascular Research Laboratory, Departments of Medicine Cardiology and Physiology, David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA
    Biophys J 85:3600-11. 2003
    ..This model successfully reproduces sizer, timer, and the restriction point features of the eukaryotic cell cycle, in addition to other experimental findings...
  49. ncbi Frailty in relation to the accumulation of deficits
    Kenneth Rockwood
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 2E1
    J Gerontol A Biol Sci Med Sci 62:722-7. 2007
    ..Future studies include the application of network analyses and stochastic analytical techniques to the evaluation of the frailty index and the description of other state variables in relation to frailty...
  50. ncbi Large-scale neural dynamics: simple and complex
    S Coombes
    School of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK
    Neuroimage 52:731-9. 2010
    ....
  51. ncbi Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo
    Osamu Shimmi
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cell 120:873-86. 2005
    ..Finally, we demonstrate mathematically that heterodimer levels can be less sensitive to changes in gene dosage than homodimers, thereby providing further selective advantage for using heterodimers as morphogens...
  52. pmc Estimating recombination rates from population genetic data
    P Fearnhead
    Department of Statistics, University of Oxford, Oxford, OX1 3TG, United Kingdom
    Genetics 159:1299-318. 2001
    ..We also performed a simulation study to look at the properties of the maximum-likelihood estimator of the recombination rate and its robustness to misspecification of the demographic model...
  53. ncbi Velocity and hierarchical spread of epidemic outbreaks in scale-free networks
    Marc Barthelemy
    CEA Centre d Etudes de Bruyères le Châtel, Département de Physique Théorique et Appliquée, BP12, 91680 Bruyères le Châtel, France
    Phys Rev Lett 92:178701. 2004
    ..Once the highly connected hubs are reached, the infection pervades the network in a progressive cascade across smaller degree classes. The present results are relevant for the development of adaptive containment strategies...
  54. ncbi The health and well-being of caregivers of children with cerebral palsy
    Parminder Raina
    Department of Clinical Epidemiology and Biostatistics, McMaster Evidence based Practice Centre, Hamilton, ON, Canada
    Pediatrics 115:e626-36. 2005
    ..The primary objective of the current study was to examine, within a single theory-based multidimensional model, the determinants of physical and psychological health of adult caregivers of children with CP...
  55. pmc Modeling the worldwide spread of pandemic influenza: baseline case and containment interventions
    Vittoria Colizza
    School of Informatics and Center for Biocomplexity, Indiana University, Bloomington, Indiana, United States of America
    PLoS Med 4:e13. 2007
    ..Here we study the worldwide spread of a pandemic and its possible containment at a global level taking into account all available information on air travel...
  56. ncbi Network analysis of protein structures identifies functional residues
    Gil Amitai
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Mol Biol 344:1135-46. 2004
    ..Closeness integrates the effect of the entire protein on single residues. Such natural structural design may be evolutionary maintained to preserve interaction redundancy and contribute to optimal setting of functional sites...
  57. ncbi Evolving public perceptions and stability in vaccine uptake
    Timothy C Reluga
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Math Biosci 204:185-98. 2006
    ..This research illustrates the importance of applying temporal models to an inherently temporal situation, namely, the time evolution of vaccine coverage in an informed population with a voluntary vaccination policy...
  58. pmc Separate and unequal: residential segregation and estimated cancer risks associated with ambient air toxics in U.S. metropolitan areas
    Rachel Morello-Frosch
    Department of Community Health, School of Medicine, Brown University, Providence, Rhode Island 02912 1943, USA
    Environ Health Perspect 114:386-93. 2006
    ..32; 95% CI, 1.16-1.51). Results suggest that disparities associated with ambient air toxics are affected by segregation and that these exposures may have health significance for populations across racial lines...
  59. ncbi Heritability of smoking initiation and nicotine dependence
    Jacqueline M Vink
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Behav Genet 35:397-406. 2005
    ..The substantial impact of genetic factors on nicotine dependence emphasizes the need for further research to localize and identify specific genes and pathways involved in nicotine dependence...
  60. ncbi Potential impacts of a warming climate on water availability in snow-dominated regions
    T P Barnett
    Climate Research Division, Scripps Institution of Oceanography, La Jolla, California 92093, USA
    Nature 438:303-9. 2005
    ....
  61. ncbi The role of mathematical modelling in the control of the 2001 FMD epidemic in the UK
    Rowland R Kao
    Dept of Zoology, University of Oxford, South Parks Road, OX1 3PS, Oxford, UK
    Trends Microbiol 10:279-86. 2002
    ..Here, the different modelling exercises that were developed over the course of the epidemic are reviewed, describing the difficulties in interpreting the available data and the appropriateness of the various assumptions...
  62. ncbi Stable isotopes as one of nature's ecological recorders
    Jason B West
    Department of Biology, University of Utah, Salt Lake City, UT 84115, USA
    Trends Ecol Evol 21:408-14. 2006
    ..The melding of advances in genetics, biochemical profiling and spatial analysis with those in isotope analyses and modeling sophistication opens the door to an exciting future in ecological research...
  63. pmc Kinetics of influenza A virus infection in humans
    Prasith Baccam
    Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    J Virol 80:7590-9. 2006
    ....
  64. ncbi Uniqueness theorems in bioluminescence tomography
    Ge Wang
    Bioluminescence Tomography Laboratory, Departments of Radiology, Biomedical Engineering, and Mathematics, University of Iowa, Iowa City, Iowa 52242, USA
    Med Phys 31:2289-99. 2004
    ..For better readability, the exact conditions for and rigorous proofs of the theorems are given in the Appendices. Further research directions are also discussed...
  65. ncbi A theoretical model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase 2
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 279:39105-14. 2004
    ....
  66. ncbi Niche dynamics in space and time
    Peter B Pearman
    University of Lausanne, Department of Ecology and Evolution, Lausanne, Switzerland
    Trends Ecol Evol 23:149-58. 2008
    ..This will improve confidence in SDM-based predictions of the impacts of climate change and species invasions on species distributions and biodiversity...
  67. ncbi A biochemical model of matrix metalloproteinase 9 activation and inhibition
    Prakash Vempati
    Department of Biomedical Engineering, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Biol Chem 282:37585-96. 2007
    ..In all, our analysis serves as a summary of existing kinetic data for MMP9 and a foundation for future models utilizing MMP9 or other MMPs under physiologically well defined microenvironments...
  68. pmc The 1918-1919 influenza pandemic in England and Wales: spatial patterns in transmissibility and mortality impact
    Gerardo Chowell
    School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287, USA
    Proc Biol Sci 275:501-9. 2008
    ..Further studies of the geographical mortality patterns associated with the 1918-1919 influenza pandemic may be useful for pandemic planning...
  69. ncbi Relating protein motion to catalysis
    Sharon Hammes-Schiffer
    Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Annu Rev Biochem 75:519-41. 2006
    ..This network is comprised of fast thermal motions that are in equilibrium as the reaction progresses along the reaction coordinate and that lead to slower equilibrium conformational changes conducive to the chemical reaction...
  70. pmc Personal exposure meets risk assessment: a comparison of measured and modeled exposures and risks in an urban community
    Devon C Payne-Sturges
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Environ Health Perspect 112:589-98. 2004
    ..Results from our study underscore the need for a coordinated multimedia approach to exposure assessment for setting public health policy...
  71. pmc Multiple-basin energy landscapes for large-amplitude conformational motions of proteins: Structure-based molecular dynamics simulations
    Kei Ichi Okazaki
    Graduate School of Natural Science and Technology, Kobe University, Kobe 657 8501, Japan
    Proc Natl Acad Sci U S A 103:11844-9. 2006
    ..The conformational transition rate varies linearly with driving force over a fairly large range. This linearity appears to be a consequence of partial unfolding during the conformational transition...
  72. pmc The genetics of geometry
    Enrico Coen
    Department of Cell and Developmental Biology, John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 101:4728-35. 2004
    ..The results can be compared with experimental observations of growth of normal and mutant forms, allowing further hypotheses and experiments to be formulated. We illustrate these principles with a study of snapdragon petal growth...
  73. pmc International issues on human health effects of exposure to chemical mixtures
    Victor J Feron
    TNO Nutrition and Food Research, Toxicology Division, Zeist, The Netherlands
    Environ Health Perspect 110:893-9. 2002
    ..Therefore, in view of limited resources for toxicological research, the focus in toxicology should be on priority mixtures--priority being determined by (estimated) health risk (= toxicity and exposure)...
  74. pmc A model of antibiotic-resistant bacterial epidemics in hospitals
    Glenn F Webb
    Department of Mathematics, Vanderbilt University, Nashville, TN 37240, USA
    Proc Natl Acad Sci U S A 102:13343-8. 2005
    ....
  75. pmc Electrostatics and the gating pore of Shaker potassium channels
    L D Islas
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Gen Physiol 117:69-89. 2001
    ..We suggest that this cavity is made by a bundle of transmembrane helices, and that the gating charge movement occurs by translocation of charged residues across a thin septum of approximately 3-7 A thickness...
  76. ncbi Defining quality of care
    S M Campbell
    National Primary Care Research and Development Centre, The University of Manchester, UK
    Soc Sci Med 51:1611-25. 2000
    ..Using a conceptual framework to describe the totality of quality of care shows which aspects of care any set of quality indicators actually includes and measures and, and which are not included...
  77. ncbi On differential variability of expression ratios: improving statistical inference about gene expression changes from microarray data
    M A Newton
    Department of Statistics, University of Wisconsin, Madison, WI 53792, USA
    J Comput Biol 8:37-52. 2001
    ..Significant gene expression changes are identified by deriving the posterior odds of change within a similar model. The methods are tested via simulation and are applied to a panel of Escherichia coli microarrays...
  78. ncbi Reconciling niche and neutrality: the continuum hypothesis
    Dominique Gravel
    Ecol Lett 9:399-409. 2006
    ..The equilibrium community consists of a set of complementary and redundant species, with their abundance determined, respectively, by the distribution of environmental conditions and the amount of immigration...
  79. pmc Performance of in-hospital mortality prediction models for acute hospitalization: hospital standardized mortality ratio in Japan
    Hiroaki Miyata
    Department of Healthcare Quality Assessment, Graduate School of Medicine, University of Tokyo, Japan
    BMC Health Serv Res 8:229. 2008
    ..We set out to develop in-hospital mortality prediction models for acute hospitalization using a nation-wide electronic administrative record system in Japan...
  80. pmc Automated generation of heuristics for biological sequence comparison
    Guy St C Slater
    The Ensembl Group, EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    BMC Bioinformatics 6:31. 2005
    ....
  81. pmc A mathematical model of glioblastoma tumor spheroid invasion in a three-dimensional in vitro experiment
    Andrew M Stein
    Department of Mathematics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biophys J 92:356-65. 2007
    ..The model suggests that differences in tumor cell dispersion may be due to differences in the chemical factors produced by cells, differences in how the two cell lines remodel the gel, or different cell-cell adhesion characteristics...
  82. ncbi The human genetic history of the Americas: the final frontier
    Dennis H O'Rourke
    Department of Anthropology, University of Utah, 270 S 1400 E, rm 102, Salt Lake City, UT 84112, USA
    Curr Biol 20:R202-7. 2010
    ....
  83. ncbi How much would closing schools reduce transmission during an influenza pandemic?
    Kathryn Glass
    National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia
    Epidemiology 18:623-8. 2007
    ..Although schools have been closed to slow the spread of influenza, there is limited evidence as to the impact on transmission of disease...
  84. pmc Estimating the effectiveness of simian immunodeficiency virus-specific CD8+ T cells from the dynamics of viral immune escape
    Judith N Mandl
    Graduate Program in Population Biology, Ecology, and Evolution, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    J Virol 81:11982-91. 2007
    ....
  85. pmc Stochastic regulation in early immune response
    Tomasz Lipniacki
    Institute of Fundamental Technological Research, Warsaw, Poland
    Biophys J 90:725-42. 2006
    ..Our theoretical predictions of single cell kinetics are supported by recent experimental studies of oscillations in NF-kappaB signaling made on single cells...
  86. ncbi Theoretical neuroanatomy: relating anatomical and functional connectivity in graphs and cortical connection matrices
    O Sporns
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cereb Cortex 10:127-41. 2000
    ..We hypothesize that adaptation to rich sensory environments and motor demands requires complex dynamics and that these dynamics are supported by neuroanatomical motifs that are characteristic of the cerebral cortex...
  87. pmc Modelling equine influenza 1: a stochastic model of within-yard epidemics
    K Glass
    Department of Zoology, University of Cambridge, UK
    Epidemiol Infect 128:491-502. 2002
    ..We develop a modified model that incorporates some heterogeneity in levels of infectivity, and compare this with the simpler model...
  88. ncbi Life-course epidemiology: concepts and theoretical models and its relevance to chronic oral conditions
    B Nicolau
    Unité d Epidémiologie et Biostatistique, INRS Institut Armand Frappier, Laval, QC, Canada
    Community Dent Oral Epidemiol 35:241-9. 2007
    ..The aim of this paper is to give an overview of this new epidemiological approach and to discuss how the life-course framework has been applied to chronic oral conditions...
  89. ncbi A GIS tool to estimate West Nile virus risk based on a degree-day model
    Li Zou
    Department of Renewable Resources, University of Wyoming, Laramie, WY 82071, USA
    Environ Monit Assess 129:413-20. 2007
    ..The model represents a useful method for estimating potential West Nile virus activity in a large spatial scale...
  90. pmc Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis
    M Bentele
    Division Theoretical Bioinformatics, German Caner Research Center DKFZ, Heidelberg 69120, Germany
    J Cell Biol 166:839-51. 2004
    ..Our model describes the regulation of apoptosis on a systems level and resolves the important question of a threshold mechanism for the regulation of apoptosis...
  91. ncbi Potential of environmental models to predict meningitis epidemics in Africa
    Madeleine C Thomson
    International Research Institute for Climate and Society, The Earth Institute of Columbia University, Palisades, NY 10964, USA
    Trop Med Int Health 11:781-8. 2006
    ..Meningococcal meningitis is a major public health problem in Africa. This report explores the potential for climate/environmental models to predict the probability of occurrence of meningitis epidemics...
  92. pmc Transcriptional regulation by the numbers: models
    Lacramioara Bintu
    Physics Department, Brandeis University, Waltham, MA 02454, USA
    Curr Opin Genet Dev 15:116-24. 2005
    ..This analysis culminates in an expression for the probability of RNA polymerase binding at the promoter of interest as a function of the number of regulatory proteins in the cell...
  93. pmc Theoretical uncertainty of measurements using quantitative polymerase chain reaction
    J Peccoud
    TIMC IMAG, Institut Albert Bonniot, Faculte de Medecine de Grenoble, La Tronche
    Biophys J 71:101-8. 1996
    ..The confidence interval amplitude is the theoretical uncertainty of measurements using quantitative PCR. We expect these results to be applicable to the data produced by the next generation of thermocyclers for quantitative applications...
  94. ncbi Global pattern of trends in streamflow and water availability in a changing climate
    P C D Milly
    US Geological Survey, Geophysical Fluid Dynamics Laboratory NOAA, PO Box 308, Princeton, New Jersey 08542, USA
    Nature 438:347-50. 2005
    ..Such changes in sustainable water availability would have considerable regional-scale consequences for economies as well as ecosystems...
  95. ncbi Expressing leaf water and cellulose oxygen isotope ratios as enrichment above source water reveals evidence of a Péclet effect
    Margaret M Barbour
    Landcare Research, P O Box 69, 8152 Lincoln, New Zealand
    Oecologia 138:426-35. 2004
    ..Further, we demonstrate that the subtle variations in Delta(L) and Delta(cell) caused by a Péclet effect may be masked in experimental systems in which variation in the source water oxygen isotope ratio is considerable...
  96. ncbi Mathematical modelling: a tool for hospital infection control
    H Grundmann
    National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Lancet Infect Dis 6:39-45. 2006
    ..We also appraise their usefulness and limitations as an innovative research and decision tool for control purposes...
  97. ncbi Pattern-oriented modeling of agent-based complex systems: lessons from ecology
    Volker Grimm
    UFZ Umweltforschungszentrum Leipzig Halle, Department Okologische Systemanalyse, PF 500 136, 04301 Leipzig, Germany
    Science 310:987-91. 2005
    ..This strategy provides a unifying framework for decoding the internal organization of agent-based complex systems and may lead toward unifying algorithmic theories of the relation between adaptive behavior and system complexity...
  98. pmc Additivity in protein-DNA interactions: how good an approximation is it?
    Panayiotis V Benos
    Department of Genetics, Campus Box 8232, Washington University, School of Medicine, St Louis, MO 63110, USA
    Nucleic Acids Res 30:4442-51. 2002
    ..Therefore, additive models can be very useful for the discovery and prediction of binding sites in genomic DNA...
  99. ncbi Association of influenza epidemics with global climate variability
    Cecile Viboud
    Institut National de la Sante et de la Recherche Medicale, Unit 444, Epidemiology and Information Sciences, Centre Hospitalo Universitaire Saint Antoine, France
    Eur J Epidemiol 19:1055-9. 2004
    ..Recognition of this association could lead to better understanding of the mechanisms of emergence of influenza epidemics...
  100. pmc Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release
    Eric A Sobie
    Medical Biotechnology Center, University of Maryland Biotechnology Center, Baltimore, Maryland 21201, USA
    Biophys J 83:59-78. 2002
    ..This new model of Ca(2+) spark behavior provides a "proof of principle" test of a new hypothesis for Ca(2+) spark termination and reproduces critical features of Ca(2+) sparks observed experimentally...
  101. ncbi Coil optimization for magnetic brain stimulation
    J Ruohonen
    BioMag Laboratory, Helsinki University Central Hospital, University of Helsinki, Finland
    Ann Biomed Eng 25:840-9. 1997
    ..It is demonstrated that today's coils are far from optimal and that, for instance, the power consumption can be reduced remarkably from the level of today's equipment. Improvements may act as a springboard toward new applications...

Research Grants78

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  2. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..We propose to develop anionic, partially lipophilic hyaluronic acid derivatives as a simple mechanistically-based treatment for this chronic extraordinarily common dental disorder. ..
  3. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..abstract_text> ..
  4. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
    ....
  5. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..At present there are no approved prophylactic measures. We are developing a novel drug that targets the basic mechanisms of this condition and will test this agent in a clinically-relevant animal model. ..
  6. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..We will now test this agent in a series of investigations in order to determine the optimal dose, to confirm the mechanism of action, and to establish the window of opportunity after disease onset within which therapy may be initiated. ..
  7. Right ventricular contractile dysfunction after pressure overload
    CLIFFORD RUSSELL GREYSON; Fiscal Year: 2013
    ..Agents with potential clinical utility will be identified using the isolated papillary muscle model and tested in the pig model. ..
  8. Behavioral Activation Therapy for Rural Veterans with Diabetes and Depression
    Aanand Dinkar Naik; Fiscal Year: 2013
    ..The application and conceptualization of interventions are well grounded and driven by relevant theoretical models including the transactional model of stress and coping, the Re-Aim framework to evaluate impact, and the 5 A&..
  9. MOLECULAR BASIS OF REOVIRUS PATHOGENESIS
    Terence S Dermody; Fiscal Year: 2013
    ..abstract_text> ..
  10. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    FREDERIC TREMAINE BILLINGS; Fiscal Year: 2013
    ..Strong institutional investment in the candidate optimizes his likelihood of progressing to independence and impacting on adverse effects of surgery. ..
  11. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ....
  12. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..These assays will provide a novel diagnostic/prognostic tools and serve as "safety biomarkers." according to the FDA. ..
  13. X chromosome, injury and infection
    Zoltan Spolarics; Fiscal Year: 2012
    ..Better understanding of the protecting cellular mechanisms that are in effect during septic conditions could lead to advanced protocols in treating the critically ill. ..
  14. Novel genomic effects of Y-linked polymorphisms
    Daniel L Hartl; Fiscal Year: 2012
    ..We will also develop theoretical models for the population dynamics of polymorphic Y chromosomes associated with YRV to determine whether a model ..
  15. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2013
    ..This research project is designed to determine how alcohol and HIV-1 interact to make the lung susceptible to injury, and to develop effective treatments that can improve the health of these vulnerable individuals. ..
  16. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ....
  17. PARP inhibitor and Redox Catalyst Conjugate for Traumatic Brain Injury
    Kanneganti Murthy; Fiscal Year: 2012
    ..We are developing a novel drug that targets the basic mechanisms of this condition and will test this agent in a clinically-relevant animal model. ..
  18. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
    ..In this proposal, we will identify the host-pathogen interactions that are the foundation of vaccine-induced resistance. The knowledge gained from this research will lead to the development of fungal vaccines and adjuvants. ..
  19. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..Consequently, it will identify another component (Ac-SDKP) as part of the multiple mediators participating in the cardioprotective effects of ACEi in hypertension. ..
  20. Liver disease in CF: CFTR controls innate immunity in biliary epithelium
    Mario Strazzabosco; Fiscal Year: 2013
    ....
  21. Novel drug VS-105 for treatment of diabetic nephropathy
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ....
  22. Oxidative Stress in Chronic Kidney Disease
    Talat Alp Ikizler; Fiscal Year: 2012
    ..We further hypothesize that implementation of caloric restriction and aerobic exercise is feasible and can improve the metabolic milieu. ..
  23. Role of endothelin receptors in glaucomatous optic neuropathy
    Raghu R Krishnamoorthy; Fiscal Year: 2013
    ..The information gained from this study could be useful in developing endothelin receptor antagonists as neuroprotective agents in glaucoma treatment. ..
  24. MOLECULAR BIOLOGY OF HEMORRHAGIC SHOCK
    Timothy R Billiar; Fiscal Year: 2013
    ..Based on our progress thus far, we are fully confident that our approach will continue to lead to productive collaboration and effective testing of a novel and important hypotheses. ..
  25. Role of Subdiaphragmatic Vagus in Fibromyalgia Syndrome
    JON DAVID LEVINE; Fiscal Year: 2013
    ..The findings should help tailor specific therapies that may prevent or at least ameliorate their significant suffering. ..
  26. Mechanism of eNOS Uncoupling in the Renal Microvasculature
    YVES CLAUDE GORIN; Fiscal Year: 2013
    ..abstract_text> ..
  27. Beta-cell Compensation in Partial Pancreatectomy Mice
    JOHN L LEAHY; Fiscal Year: 2013
    ..abstract_text> ..
  28. Validation of a Novel NF-kB Inhibitor in Inflammatory Bowel Disease
    Anthony Blikslager; Fiscal Year: 2013
    ..It is our hope that the work performed in this application will lead to clinical development in humans in the next phase. ..
  29. Role of natural indoles in experimental autoimmune encephalomyelitis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..These studies should provide novel insights into the basic mechanisms through which plant indoles exhibit anti- inflammatory properties so that they can be used against a wide range of autoimmune and inflammatory diseases. ..
  30. Nitric Oxide and gastric motility in female diabetics
    Pandu R Gangula; Fiscal Year: 2010
    ..Further, it may lead to the discovery of novel therapeutic targets for the management of this challenging clinical syndrome. ..
  31. Genetics of Angiotensinogen-Mediated Hypertension: Stage, Background & Gender
    Donald E Kohan; Fiscal Year: 2010
    ..Our goal is to advance the specificity of clinical management and treatment of EH. ..
  32. Biophysics of the morphology and motility of Borrelia burgdorferi in diverse envi
    Charles W Wolgemuth; Fiscal Year: 2013
    ....
  33. AMPK Endothelial Cell Dysfunction and the Metabolic Syndrome (PROGRAM PROJECT)
    Neil B Ruderman; Fiscal Year: 2013
    ..The proposed studies should both yield novel insights into the biological bases for the premature atherosclerosis and impaired angiogenesis associated with this entity and suggest new therapeutic targets for their prevention...
  34. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
    ..This will provide a basis for potential further development of BB3 as a therapeutic for emphysema. ..
  35. Host Defense Mechanisms in Polyaromatic Hydrogen Carcinogenesis
    Craig A Elmets; Fiscal Year: 2013
    ..We have developed novel reagents and we utilize them as a vaccine to determine if they augment immunity to PAHs and can be used to prevent tumors from developing in the first place. ..
  36. Building Mouse Models of Metabolic Syndrome
    Karen L Svenson; Fiscal Year: 2013
    ..A better understanding of the progression of this condition and the genetic factors that contribute to it will aid the development of effective treatment and prevention strategies. ..
  37. Genetic Basis for Impaired Angiogenic Signaling in BPD
    STEVEN HERBERT ABMAN; Fiscal Year: 2012
    ..abstract_text> ..
  38. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2012
    ..A better understanding of these processes will help to improve the treatment of this potentially fatal condition. ..
  39. IL-22 in epithelial regeneration after allogeneic transplant
    Alan Hanash; Fiscal Year: 2013
    ..In addition, the career development goal of this project is to help Dr. Hanash transition into an independent investigator with his own laboratory and R01 funding. ..
  40. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: A small molecule organ protective agent has significant clinical potential in renal transplantation. ..
  41. Effect of Prone Position on Ventilator-Induced Lung Injury
    Guido Musch; Fiscal Year: 2013
    ..In this research, we will test whether promoting uniform lung inflation and tidal expansion by prone positioning reduces neutrophil metabolic activation, an early and important event in the pathogenesis of VILI. ..
  42. Astrocytes Play a Critical Role in the Pathology of EAE
    JOHN ROLAND BETHEA; Fiscal Year: 2013
    ..Ultimately, our goal is to determine if interfering with these responses could be beneficial as a therapeutic strategy for MS and other neurological disorders. ..
  43. Genome instability in leukemia stem cell
    Tomasz Skorski; Fiscal Year: 2010
    ..These studies will break ground toward new directions in studying LSCs in CML and other leukemias, and in testing of novel therapeutic strategies. ..
  44. Counter-Regulation of TLR-Driven Mucosal Inflammation
    Erik P Lillehoj; Fiscal Year: 2010
    ..Successful accomplishment of this project will provide pharmacological strategies to control excessive inflammation during airway bacterial colonization of mucosal surfaces. ..
  45. DAMP-RAGE Signaling and Fetal Injury in Inflammation-Induced Preterm Birth
    Irina A Buhimschi; Fiscal Year: 2013
    ..abstract_text> ..
  46. Role of Meprin A in Acute Kidney Injury
    GUR PRASAD KAUSHAL; Fiscal Year: 2013
    ..In addition the study will identify meprin A-mediated urinary markers for early detection of AKI. Therefore, the proposal is clinically relevant to the VA patient population since a large segment of veterans suffer from AKI. ..
  47. Phospholemman and Cardiac Contracility
    Joseph Y Cheung; Fiscal Year: 2013
    ..In addition, the exact molecular site in sodium-calcium exchanger interacting with phospholemman will be mapped out by mutagenesis. ..
  48. Microdialysis Studies of Seizure-Induced Oxidative Stress
    Craig E Lunte; Fiscal Year: 2013
    ....
  49. Prenatal stress and epigenetic programming of the HPA axis and autonomic balance
    Rosalind J Wright; Fiscal Year: 2013
    ..While a number of theoretical models explaining how social conditions "get into the body" to impact health have been proposed, the psychosocial ..
  50. Therapeutic Potential of PARP inhibitor for Acute Pancreatitis
    Latha Paka; Fiscal Year: 2010
    ..Our therapeutic strategy in the current project is to test our lead PARP inhibitors in two invivo models of AP and identifify one of the best PARP inhibitor to further studies in Phase II and potentially a clinical product. ..
  51. Cardioprotective Actions of Hydrogen Sulfide
    DAVID JOSEPH LEFER; Fiscal Year: 2013
    ..Information gained from these studies will help with the development of novel therapies for the treatment of patients suffering from acute myocardial infarction. ..
  52. Mechanism of PsrP mediated adhesion
    Carlos J Orihuela; Fiscal Year: 2013
    ..We will determine if passive vaccination with mAbs and active vaccination with recombinant BR constructs protects mice against pneumococcal challenge. ..
  53. Enhancing Plasticity in Damaged Spinal Cord to Repair Transmission and Function
    Victor L Arvanian; Fiscal Year: 2013
    ..Preliminary results of on-going experiments show significant improvements of motor function in rats that have received the novel triple treatment compared to controls after thoracic contusive SCI. ..
  54. Mechanisms of Postoperative Ileus
    YVETTE FRANCE TACHE; Fiscal Year: 2012
    ....
  55. Integration of sleep/wake network models across multiple temporal and spatial sca
    ANDREW JOHN PHILLIPS; Fiscal Year: 2013
    ..have been used for relating behavioral phenotypes to underlying physiology and testing assumptions about our theoretical models of sleep...
  56. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2013
    ....
  57. Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic Receptors
    DAVID KEM; Fiscal Year: 2013
    ..Our studies are directed toward establishing this association with atrial fibrillation and to develop future preventative measures and treatment. ..
  58. Association of a common variant of the PPAP2B gene with cardiovascular disease.
    Andrew J Morris; Fiscal Year: 2013
    ..Establishing PPAP2B, its product LPP3 and the lipid substrates of this enzyme as risk predictors and mediators of CAD promises to identify important and innovative targets for the development of new biomarkers and/or therapeutics. ..
  59. Central Mechanisms Modulating Visceral Sensitivity
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..Our findings may identify targets for the development of novel therapeutic strategies directed at the brain, to improve the treatment or even reduce the risk for the development of anxiety-linked visceral pain in Veterans. ..
  60. Angiotensin-induced Oxidants and Vascular Cell Phenotype
    Richard Cohen; Fiscal Year: 2009
    ..abstract_text> ..
  61. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT STEPHEN CHAPKIN; Fiscal Year: 2012
    ....
  62. Suppression of Collagen Induced Arthritis with Altered Peptide Ligands
    Andrew H Kang; Fiscal Year: 2010
    ..Other peptidesef that a definitive understanding of the mechanism(s) through which A9 suppresses arthritis will facilitate the development of improved treatments for RA. ..
  63. Self-Sensing Physiologic Control of a Rotary Mag Lev LVAD
    JAMES FARLEY WALTON; Fiscal Year: 2010
    ..The success of early developments has resulted in the use of circulatory assistance for short durations [2, 3, 4], however new developments are needed to make long duration use of these heart assist devices possible. ..
  64. Exchangeable Heart Valve for Tissue Engineering Applications
    Ivan Vesely; Fiscal Year: 2007
    ..VXI will thus continue to advance the field of heart valve technologies into new areas where innovative solutions for patients with heart valve disease are needed. [unreadable] [unreadable] [unreadable]..
  65. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010
    ....
  66. Significance of Caspase-Mediated Cleavage of PARP-1 in Cell Death
    KAREN DAVID; Fiscal Year: 2007
    ..We believe that understanding the functional significance of this cleavage will help in developing therapeutic intervention to combat aging-related diseases and cell death. [unreadable] [unreadable] [unreadable]..
  67. EXPERIMENTAL MODELS AND CLINICAL VIROLOGY OF HEPATITIS C
    Nelson Fausto; Fiscal Year: 1999
    ..These studies are expected to contribute in fundamental ways to the understanding of the pathogenesis of hepatitis C and to devising novel approaches for treatment. ..
  68. Immune Tolerance and Autoimmunity
    Abul K Abbas; Fiscal Year: 2010
    ..The results are not only of biological significance, but will also provide valuable leads for strategies to induce tolerance as a therapeutic modality. ..
  69. ENGINEERING INTEGRIN--MEDIATED CELL MIGRATION
    Douglas Lauffenburger; Fiscal Year: 2002
    ..The knowledge gained from these studies may help to control the cell migration in tissue engineering applications. ..
  70. Genomic Approaches to Neuronal Diversity and Plasticity
    Jingyue Ju; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .................................................................................................................................................. 1 Description, ..
  71. MOLECULAR AND CELLULAR REGULATION OF TOLERANCE
    Yongwon Choi; Fiscal Year: 2010
    ..Thus, understanding molecular and cellular pathways that properly control immune responses will provide the foundation for novel intervention strategies to treat various chronic inflammatory diseases. ..
  72. REGIONAL MECHANICS OF LEFT VENTRICULAR ANEURYSM
    Julius Guccione; Fiscal Year: 1999
    ..The long-term goal of this research is to use experimental and theoretical models to develop new operations for aneurysm repair...
  73. GLYCINE POTENTIATION OF ANTICONVULSANT DRUGS
    Steven Peterson; Fiscal Year: 1991
    ..The results will also contribute to the understanding of the role of glycine in the mechanisms of convulsions and the neuropharmacology of anticonvulsant drugs, particularly in relation to GABA mechanisms in the substantia nigra...
  74. Experimental Model For Pressure Ulcers In Human Skin: The Role of Aging and ECM
    Marjana Tomic Canic; Fiscal Year: 2009
    ..An experimental model for pressure ulcers will not only provide an understanding of the underlying mechanisms of pathogenesis, but also allow for pre- clinical testing of potential therapeutic modalities. ..
  75. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2003
    ..Follow up will be done with MRI and EDSS at 18 and 24 months after enrollment(secondary outcome). The study will will allow us to achieve a power of 85 percent (32 percent reduction in plaque burden). ..
  76. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2005
    ..Follow up will be done with MRI and EDSS at 18 and 24 months after enrollment(secondary outcome). The study will will allow us to achieve a power of 85 percent (32 percent reduction in plaque burden). ..
  77. THROMBIN AND VWF IN SHIGA-TOXIN-ASSOCIATED HUS
    Thomas Raife; Fiscal Year: 2001
    ..In addition, prevention or reduction of adverse outcomes of microvascular thrombosis in this animal model may lead directly to possibilities for improved patient care in humans. ..
  78. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2010
    ..Additionally, the analysis of the model will provide guidance for more effective treatment strategies to hopefully reduce the numbers of HME cases. ..