research design

Summary

Summary: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.

Top Publications

  1. pmc CONSORT statement: extension to cluster randomised trials
    Marion K Campbell
    Health Services Research Unit, University of Aberdeen, Aberdeen, AB25 2ZD
    BMJ 328:702-8. 2004
  2. ncbi Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration
    Isabelle Boutron
    INSERM U738, AP HP, Hopital Bichat Claude Bernard, and Université Paris 7 Denis Diderot, Paris, France
    Ann Intern Med 148:295-309. 2008
  3. ncbi Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials
    Jelena Savovic
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Ann Intern Med 157:429-38. 2012
  4. ncbi Review: a gentle introduction to imputation of missing values
    A Rogier T Donders
    Center for Biostatistics, Utrecht University, Utrecht, The Netherlands
    J Clin Epidemiol 59:1087-91. 2006
  5. ncbi Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy
    Sean R Tunis
    Office of Clinical Standards and Quality, Centers for Medicare and Medicaid Services, Baltimore, MD 21244, USA
    JAMA 290:1624-32. 2003
  6. doi CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials
    Kenneth F Schulz
    Family Health International, Research Triangle Park, North Carolina 27709, USA
    Ann Intern Med 152:726-32. 2010
  7. pmc Why most published research findings are false
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS Med 2:e124. 2005
  8. pmc CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
    Kenneth F Schulz
    Family Health International, Research Triangle Park, NC 27709, USA
    BMC Med 8:18. 2010
  9. ncbi The estimation of a preference-based measure of health from the SF-12
    John E Brazier
    Health Economics and Decision Science Group, School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom
    Med Care 42:851-9. 2004
  10. pmc SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials
    An Wen Chan
    Women s College Research Institute at Women s College Hospital, Department of Medicine, University of Toronto, Toronto, Canada M5G 1N8
    BMJ 346:e7586. 2013

Detail Information

Publications346 found, 100 shown here

  1. pmc CONSORT statement: extension to cluster randomised trials
    Marion K Campbell
    Health Services Research Unit, University of Aberdeen, Aberdeen, AB25 2ZD
    BMJ 328:702-8. 2004
  2. ncbi Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration
    Isabelle Boutron
    INSERM U738, AP HP, Hopital Bichat Claude Bernard, and Université Paris 7 Denis Diderot, Paris, France
    Ann Intern Med 148:295-309. 2008
    ..This extension, in conjunction with the main CONSORT Statement and other CONSORT extensions, should help to improve the reporting of RCTs performed in this field...
  3. ncbi Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials
    Jelena Savovic
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Ann Intern Med 157:429-38. 2012
    ..Bias associated with study design characteristics may lead to exaggeration of intervention effect estimates and increases in between-trial heterogeneity in trials reporting subjectively assessed outcomes...
  4. ncbi Review: a gentle introduction to imputation of missing values
    A Rogier T Donders
    Center for Biostatistics, Utrecht University, Utrecht, The Netherlands
    J Clin Epidemiol 59:1087-91. 2006
    ..We also explain and illustrate why two frequently used methods to handle missing data, i.e., overall mean imputation and the missing-indicator method, almost always result in biased estimates...
  5. ncbi Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy
    Sean R Tunis
    Office of Clinical Standards and Quality, Centers for Medicare and Medicaid Services, Baltimore, MD 21244, USA
    JAMA 290:1624-32. 2003
    ..For these changes to occur, clinical and health policy decision makers will need to become more involved in all aspects of clinical research, including priority setting, infrastructure development, and funding...
  6. doi CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials
    Kenneth F Schulz
    Family Health International, Research Triangle Park, North Carolina 27709, USA
    Ann Intern Med 152:726-32. 2010
    ..Schulz and colleagues describe the latest version, CONSORT 2010, which updates the reporting guideline based on new methodological evidence and accumulating experience...
  7. pmc Why most published research findings are false
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    PLoS Med 2:e124. 2005
    ..In this essay, I discuss the implications of these problems for the conduct and interpretation of research...
  8. pmc CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
    Kenneth F Schulz
    Family Health International, Research Triangle Park, NC 27709, USA
    BMC Med 8:18. 2010
    ..com and will also be published in the Lancet, Obstetrics and Gynecology, PLoS Medicine, Annals of Internal Medicine, Open Medicine, Journal of Clinical Epidemiology, BMC Medicine, and Trials...
  9. ncbi The estimation of a preference-based measure of health from the SF-12
    John E Brazier
    Health Economics and Decision Science Group, School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom
    Med Care 42:851-9. 2004
    ..It has become widely used in clinical trials and routine outcome assessment because of its brevity and psychometric performance, but it cannot be used in economic evaluation in its current form...
  10. pmc SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials
    An Wen Chan
    Women s College Research Institute at Women s College Hospital, Department of Medicine, University of Toronto, Toronto, Canada M5G 1N8
    BMJ 346:e7586. 2013
    ..Complete documentation of key trial elements can facilitate transparency and protocol review for the benefit of all stakeholders...
  11. ncbi Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses
    L L Kjaergard
    Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, H S Rigshospitalet, DK 2100 Copenhagen, Denmark
    Ann Intern Med 135:982-9. 2001
    ..To explore whether reported methodologic quality affects estimated intervention effects in randomized trials and contributes to discrepancies between the results of large randomized trials and small randomized trials in meta-analyses...
  12. pmc Increasing response rates to postal questionnaires: systematic review
    Phil Edwards
    CRASH Trial Co ordinating Centre, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1B 1DP
    BMJ 324:1183. 2002
    ..To identify methods to increase response to postal questionnaires...
  13. ncbi Design and analysis of pilot studies: recommendations for good practice
    Gillian A Lancaster
    Department of Mathematical Sciences, University of Liverpool, UK
    J Eval Clin Pract 10:307-12. 2004
    ..It will also safeguard against pilot studies being conducted simply because of small numbers of available patients...
  14. pmc A tutorial on pilot studies: the what, why and how
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton ON, Canada
    BMC Med Res Methodol 10:1. 2010
    ....
  15. pmc A call for transparent reporting to optimize the predictive value of preclinical research
    Story C Landis
    National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Nature 490:187-91. 2012
    ..Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress...
  16. pmc Improving the reporting of pragmatic trials: an extension of the CONSORT statement
    Merrick Zwarenstein
    Health Services Sciences, Sunnybrook Hospital, Toronto, Ontario, Canada
    BMJ 337:a2390. 2008
    ..In the meantime we recommend that those who support, conduct, and report pragmatic trials should use this extension of the CONSORT statement to facilitate the use of trial results in decisions about health care...
  17. pmc Systematic reviews of diagnostic test accuracy
    Mariska M G Leeflang
    Dutch Cochrane Centre and Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Ann Intern Med 149:889-97. 2008
    ..Challenges that remain are the poor reporting of original diagnostic test accuracy studies and difficulties with the interpretation of the results of diagnostic test accuracy research...
  18. ncbi Comparison of two methods to detect publication bias in meta-analysis
    Jaime L Peters
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester, England
    JAMA 295:676-80. 2006
    ..However, the performance of this test and the usual funnel plot have been challenged particularly when the summary estimate is the natural log of the odds ratio (lnOR)...
  19. ncbi Outcome criteria in smoking cessation trials: proposal for a common standard
    Robert West
    University College, London, UK
    Addiction 100:299-303. 2005
    ....
  20. pmc Increasing value and reducing waste in research design, conduct, and analysis
    John P A Ioannidis
    Stanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Stanford, CA, USA Division of Epidemiology, School of Medicine, Stanford University, Stanford, CA, USA Department of Statistics, School of Humanities and Sciences, Stanford University, Stanford, CA, USA Meta Research Innovation Center at Stanford METRICS, Stanford University, Stanford, CA, USA Electronic address
    Lancet 383:166-75. 2014
    ....
  21. pmc What is missing from descriptions of treatment in trials and reviews?
    Paul Glasziou
    Centre for Evidence Based Medicine, Department of Primary Health Care, University of Oxford, Oxford OX3 7LF
    BMJ 336:1472-4. 2008
  22. ncbi Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?
    D Moher
    Children s Hospital of Eastern Ontario Research Institute, and Department of Epidemiology and Community Medicine, University of Ottawa, Canada
    Lancet 352:609-13. 1998
    ..We investigated whether different methods of quality assessment provide different estimates of intervention efficacy evaluated in randomised controlled trials (RCTs)...
  23. pmc The effectiveness of Web-based vs. non-Web-based interventions: a meta-analysis of behavioral change outcomes
    Dean J Wantland
    Department of Community Health Systems, University of California, San Francisco, N531M, School of Nursing, San Francisco CA 94143, USA
    J Med Internet Res 6:e40. 2004
    ..The use and effectiveness of Web-based interventions to encourage an individual's change in behavior compared to non-Web-based interventions have not been substantially reviewed...
  24. pmc Individual determinants of research utilization by nurses: a systematic review update
    Janet E Squires
    Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Implement Sci 6:1. 2011
    ..Systematic identification and evaluation of individual characteristics associated with and predicting research utilization may inform the development of research utilization interventions...
  25. ncbi The prevalence of comorbid depression in adults with diabetes: a meta-analysis
    R J Anderson
    Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
    Diabetes Care 24:1069-78. 2001
    ..b>RESEARCH DESIGN AND METHODS--MEDLINE and PsycINFO databases and published references were used to identify studies that ..
  26. ncbi Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa)
    Per Magnus
    Division of Epidemiology, The Norwegian Institute of Public Health, Oslo, Norway
    Int J Epidemiol 35:1146-50. 2006
  27. pmc Pragmatic controlled clinical trials in primary care: the struggle between external and internal validity
    Marshall Godwin
    Centre for Studies in Primary Care, Queen s University, Kingston K7L 5E9, Canada
    BMC Med Res Methodol 3:28. 2003
    ..We describe the design of the trials and the steps taken to deal with the competing demands of external and internal validity...
  28. pmc REporting recommendations for tumour MARKer prognostic studies (REMARK)
    L M McShane
    US National Cancer Institute, Bethesda, MD 20892, USA
    Br J Cancer 93:387-91. 2005
    ....
  29. ncbi Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Pain 9:105-21. 2008
    ..Provisional benchmarks for identifying clinically important changes in specific outcome measures that can be used for outcome studies of treatments for chronic pain are proposed...
  30. ncbi Sample size requirements for association studies of gene-gene interaction
    W James Gauderman
    Department of Preventive Medicine, School of Medicine, University of Southern California, 1540 Alcazar Street, Suite 220, Los Angeles, CA 90089, USA
    Am J Epidemiol 155:478-84. 2002
    ..A software program that computes sample size for studies of G x G interaction and for studies of gene-environment (G x E) interaction is freely available (http://hydra.usc.edu/gxe)...
  31. ncbi Patterns of intra-cluster correlation from primary care research to inform study design and analysis
    Geoffrey Adams
    Department of Public Health Sciences, King s College London, Capital House, 42 Weston Street, London SE1 3QD, UK
    J Clin Epidemiol 57:785-94. 2004
    ..To provide information concerning the magnitude of the intraclass correlation coefficient (ICC) for cluster-based studies set in primary care...
  32. ncbi Evaluation of networks of randomized trials
    Georgia Salanti
    Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
    Stat Methods Med Res 17:279-301. 2008
    ..Finally, we discuss the implications of inconsistency, network geometry and asymmetry in informing the planning of future trials...
  33. ncbi Scales to assess the quality of randomized controlled trials: a systematic review
    Susan Armijo Olivo
    University of Alberta, 3 50 Corbett Hall, Edmonton, Alberta, Canada, T6G 2G4
    Phys Ther 88:156-75. 2008
    ..The purpose of this systematic review was to identify scales used to evaluate the methodological quality of RCTs in health care research and summarize the content, construction, development, and psychometric properties of these scales...
  34. ncbi The RE-AIM framework for evaluating interventions: what can it tell us about approaches to chronic illness management?
    R E Glasgow
    AMC Cancer Research Center, Center for Behavioral and Community Studies, 1600 Pierce Street, Denver, CO 80214, USA
    Patient Educ Couns 44:119-27. 2001
    ..The RE-AIM framework is used as a method of systematically considering the strengths and weaknesses of chronic illness management interventions in order to guide program planning...
  35. pmc CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
    Kenneth F Schulz
    Family Health International, Research Triangle Park, NC 27709, USA
    Trials 11:32. 2010
    ..com and will also be published in the Lancet, Obstetrics and Gynecology, PLoS Medicine, Annals of Internal Medicine, Open Medicine, Journal of Clinical Epidemiology, BMC Medicine, and Trials...
  36. pmc Data quality of general practice electronic health records: the impact of a program of assessments, feedback, and training
    Mark Porcheret
    Primary Care Sciences Research Centre, Keele University, UK
    J Am Med Inform Assoc 11:78-86. 2004
    ..The aim of this study was to investigate the impact of a program of repeated assessments, feedback, and training on the quality of coded clinical data in general practice...
  37. ncbi Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Am Geriatr Soc 52:625-34. 2004
    ....
  38. ncbi Sample size for cluster randomized trials: effect of coefficient of variation of cluster size and analysis method
    Sandra M Eldridge
    Centre for Health Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Int J Epidemiol 35:1292-300. 2006
    ..This can affect trial power, but standard sample size formulae for these trials ignore this. Previous studies addressing this issue have mostly focused on continuous outcomes or methods that are sometimes difficult to use in practice...
  39. pmc Inconsistency between direct and indirect comparisons of competing interventions: meta-epidemiological study
    Fujian Song
    Faculty of Medicine and Health Science, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
    BMJ 343:d4909. 2011
    ..To investigate the agreement between direct and indirect comparisons of competing healthcare interventions...
  40. ncbi Evaluating the relevance, generalization, and applicability of research: issues in external validation and translation methodology
    Lawrence W Green
    University of California at San Francisco, USA
    Eval Health Prof 29:126-53. 2006
    ....
  41. ncbi Remission in schizophrenia: proposed criteria and rationale for consensus
    Nancy C Andreasen
    Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
    Am J Psychiatry 162:441-9. 2005
    ..These criteria should facilitate research and support a positive, longer-term approach to studying outcome in patients with schizophrenia...
  42. ncbi What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models
    Michael A Babyak
    Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 66:411-21. 2004
    ..Techniques that account and correct for complexity, including shrinkage and penalization, also are introduced...
  43. ncbi Towards systematic reviews that inform health care management and policy-making
    John Lavis
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Ontario, Canada
    J Health Serv Res Policy 10:35-48. 2005
    ..To identify ways to improve the usefulness of systematic reviews for health care managers and policy-makers that could then be evaluated prospectively...
  44. pmc Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, Netherlands
    BMJ 326:41-4. 2003
    ..To improve the accuracy and completeness of reporting of studies of diagnostic accuracy, to allow readers to assess the potential for bias in a study, and to evaluate a study's generalisability...
  45. ncbi Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Ann Intern Med 138:40-4. 2003
    ..To comprehend the results of diagnostic accuracy studies, readers must understand the design, conduct, analysis, and results of such studies. That goal can be achieved only through complete transparency from authors...
  46. pmc Designing and evaluating complex interventions to improve health care
    Neil C Campbell
    Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Aberdeen AB25 2AY
    BMJ 334:455-9. 2007
  47. ncbi Design and analysis of stepped wedge cluster randomized trials
    Michael A Hussey
    Fred Hutchinson Cancer Research Center, Seattle, WA, United States
    Contemp Clin Trials 28:182-91. 2007
    ..In this article we discuss the design and analysis of a particular type of crossover CRT - the stepped wedge - and provide an example of its use...
  48. ncbi How can we increase translation of research into practice? Types of evidence needed
    Russell E Glasgow
    Kaiser Permanente Colorado, Denver, CO 80231, USA
    Annu Rev Public Health 28:413-33. 2007
    ..Greater attention is needed to connectedness across program levels and components. Finally, examples are provided of evaluation models and current programs that can help accelerate translation of research to practice and policy...
  49. pmc Why don't we see more translation of health promotion research to practice? Rethinking the efficacy-to-effectiveness transition
    Russell E Glasgow
    Kaiser Permanente Colorado, USA
    Am J Public Health 93:1261-7. 2003
    ..Recommendations are offered to help close the gap between efficacy and effectiveness research and to guide evaluation and possible adoption of new programs...
  50. pmc Methodological problems in the use of indirect comparisons for evaluating healthcare interventions: survey of published systematic reviews
    Fujian Song
    Faculty of Health, University of East Anglia, Norwich NR4 7TJ
    BMJ 338:b1147. 2009
    ..To investigate basic assumptions and other methodological problems in the application of indirect comparison in systematic reviews of competing healthcare interventions...
  51. ncbi Indirect comparisons of competing interventions
    A M Glenny
    Cochrane Oral Health Group, Dental School, University of Manchester, UK
    Health Technol Assess 9:1-134, iii-iv. 2005
    ....
  52. doi Credibility of claims of subgroup effects in randomised controlled trials: systematic review
    Xin Sun
    Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA
    BMJ 344:e1553. 2012
    ..To investigate the credibility of authors' claims of subgroup effects using a representative sample of recently published randomised controlled trials...
  53. ncbi Pragmatic clinical trials
    Hugh MacPherson
    Foundation for Traditional Chinese Medicine, York, UK
    Complement Ther Med 12:136-40. 2004
    ..A case is made for the appropriate use and relevance of pragmatic trials in the evaluation of alternative and complementary medicine...
  54. pmc The quality of reports of randomised trials in 2000 and 2006: comparative study of articles indexed in PubMed
    Sally Hopewell
    Centre for Statistics in Medicine, University of Oxford, Linton Road, Oxford OX2 6UD
    BMJ 340:c723. 2010
    ....
  55. pmc Survey of the quality of experimental design, statistical analysis and reporting of research using animals
    Carol Kilkenny
    The National Centre for the Replacement, Refinement and Reduction of Animals in Research, London, United Kingdom
    PLoS ONE 4:e7824. 2009
    ....
  56. doi The science of improvement
    Donald M Berwick
    Institute for Healthcare Improvement, Cambridge, Massachusetts 02138, USA
    JAMA 299:1182-4. 2008
  57. pmc Methods for the synthesis of qualitative research: a critical review
    Elaine Barnett-Page
    Evidence for Policy and Practice Information and Co ordinating Centre, Social Science Research Unit, 18 Woburn Square, London WC1H 0NS, UK
    BMC Med Res Methodol 9:59. 2009
    ..There is a need for both researchers and commissioners to be able to distinguish between these methods and to select which method is the most appropriate to their situation...
  58. ncbi Good research practices for cost-effectiveness analysis alongside clinical trials: the ISPOR RCT-CEA Task Force report
    Scott Ramsey
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Value Health 8:521-33. 2005
    ..Its goal was to develop a guidance document for designing, conducting, and reporting cost-effectiveness analyses conducted as a part of clinical trials...
  59. pmc Quality improvement report: Improving design and conduct of randomised trials by embedding them in qualitative research: ProtecT (prostate testing for cancer and treatment) study. Commentary: presenting unbiased information to patients can be difficult
    Jenny Donovan
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR, UK
    BMJ 325:766-70. 2002
    ..Recruitment to randomised trials is often difficult, and many important trials are not mounted because recruitment is thought to be "impossible."..
  60. ncbi Enhancing treatment fidelity in health behavior change studies: best practices and recommendations from the NIH Behavior Change Consortium
    Albert J Bellg
    Appleton Cardiology Associates, Appleton Heart Institute, Appleton, WI 54911, USA
    Health Psychol 23:443-51. 2004
    ..Funding agencies, reviewers, and journal editors are encouraged to make treatment fidelity a standard part of the conduct and evaluation of health behavior intervention research...
  61. doi Good laboratory practice: preventing introduction of bias at the bench
    Malcolm R Macleod
    Centre for Clinical Brain Sciences, University of Edinburgh, UK
    Stroke 40:e50-2. 2009
    ....
  62. pmc When is informed consent required in cluster randomized trials in health research?
    Andrew D McRae
    Department of Epidemiology and Biostatistics, University of Western Ontario, London, ON N6A5C1, Canada
    Trials 12:202. 2011
    ..Fifth, while health professionals may have a moral obligation to participate as subjects in research, this does not diminish the necessity of informed consent to study participation...
  63. doi Improving the translational hit of experimental treatments in multiple sclerosis
    Hanna M Vesterinen
    Centre for Clinical Brain Sciences, Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK
    Mult Scler 16:1044-55. 2010
    ..In other neurological diseases, the failure to translate pre-clinical findings to effective clinical treatments has been partially attributed to bias introduced by shortcomings in the design of animal experiments...
  64. doi The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews
    Jamie J Kirkham
    Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool L69 3GS
    BMJ 340:c365. 2010
    ..To examine the prevalence of outcome reporting bias-the selection for publication of a subset of the original recorded outcome variables on the basis of the results-and its impact on Cochrane reviews...
  65. ncbi How to track and assess genotyping errors in population genetics studies
    A Bonin
    Laboratoire d Ecologie Alpine, CNRS UMR 5553, Universite Joseph Fourier, BP 53, 38041 Grenoble Cedex 09, France
    Mol Ecol 13:3261-73. 2004
    ....
  66. pmc Conducting a critical interpretive synthesis of the literature on access to healthcare by vulnerable groups
    Mary Dixon-Woods
    Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    BMC Med Res Methodol 6:35. 2006
    ..This approach is sensitised to the processes of conventional systematic review methodology and draws on recent advances in methods for interpretive synthesis...
  67. doi No surgical innovation without evaluation: the IDEAL recommendations
    Peter McCulloch
    Nuffield Department of Surgery, University of Oxford, Oxford, UK
    Lancet 374:1105-12. 2009
    ..Achievement of improved design, conduct, and reporting of surgical research will need concerted action by editors, funders of health care and research, regulatory bodies, and professional societies...
  68. doi Missing data analysis: making it work in the real world
    John W Graham
    Department of Biobehavioral Health and the Prevention Research Center, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Annu Rev Psychol 60:549-76. 2009
    ..Suggestions are given for moving forward with research on missing data and attrition...
  69. pmc A comparison of bayesian methods for haplotype reconstruction from population genotype data
    Matthew Stephens
    Department of Statistics, University of Washington, Seattle, WA 98195 4322, USA
    Am J Hum Genet 73:1162-9. 2003
    ..The new algorithm is included in the software package PHASE, version 2.0, available online (http://www.stat.washington.edu/stephens/software.html)...
  70. ncbi Interrupted time series designs in health technology assessment: lessons from two systematic reviews of behavior change strategies
    Craig R Ramsay
    Health Services Research Unit, University of Aberdeen, Foresterhill, UK
    Int J Technol Assess Health Care 19:613-23. 2003
    ..We critically reviewed the methodological quality of ITS designs using studies included in two systematic reviews (a review of mass media interventions and a review of guideline dissemination and implementation strategies)...
  71. doi Systems biology: experimental design
    Clemens Kreutz
    Physics Department, University of Freiburg, Germany
    FEBS J 276:923-42. 2009
    ..Furthermore, the relevant classical aspects of experimental design, such as randomization, replication and confounding, are reviewed...
  72. ncbi Methods and processes of the CONSORT Group: example of an extension for trials assessing nonpharmacologic treatments
    Isabelle Boutron
    INSERM U738, AP HP, Hopital Bichat Claude Bernard, and Université Paris 7 Denis Diderot, Paris, France
    Ann Intern Med 148:W60-6. 2008
    ..The conduct of randomized, controlled trials of nonpharmacologic treatments presents specific challenges that are not adequately addressed in trial reports...
  73. ncbi A process for systematically reviewing the literature: providing the research evidence for public health nursing interventions
    B H Thomas
    McMaster University School of Nursing, Hamilton Public Health and Community Services, Ontario, Canada
    Worldviews Evid Based Nurs 1:176-84. 2004
    ..Also, the project is expected to disseminate the results provincially, nationally, and internationally. Most of the reviews are relevant to public health nursing practice...
  74. ncbi Features and uses of high-fidelity medical simulations that lead to effective learning: a BEME systematic review
    S Barry Issenberg
    Center for Research in Medical Education, University of Miami School of Medicine, Miami, FL 33101, USA
    Med Teach 27:10-28. 2005
    ..1969 to 2003, 34 years...
  75. doi Describing reporting guidelines for health research: a systematic review
    David Moher
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada
    J Clin Epidemiol 64:718-42. 2011
    ..To describe the process of development, content, and methods of implementation of reporting guidelines for health research...
  76. ncbi Imputation of missing values is superior to complete case analysis and the missing-indicator method in multivariable diagnostic research: a clinical example
    Geert J M G van der Heijden
    Julius Center for Health Sciences and Primary Care, University Medical Center, P O Box 80035, 3508 GA Utrecht, The Netherlands
    J Clin Epidemiol 59:1102-9. 2006
    ....
  77. pmc The problem of appraising qualitative research
    M Dixon-Woods
    Department of Health Sciences, University of Leicester, Leicester LE1 6TP, UK
    Qual Saf Health Care 13:223-5. 2004
    ..There will be difficulties in doing this because some aspects of qualitative research, particularly those relating to quality of insight and interpretation, will remain difficult to appraise and will rely largely on subjective judgement...
  78. doi Unpredictable bias when using the missing indicator method or complete case analysis for missing confounder values: an empirical example
    Mirjam J Knol
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Epidemiol 63:728-36. 2010
    ..Using empirical data, we demonstrated the degree and direction of bias in the effect estimate when using these methods compared with multiple imputation (MI)...
  79. doi The effectiveness of clinical guideline implementation strategies--a synthesis of systematic review findings
    Mathew Prior
    Centre for Allied Health Evidence, University of South Australia, Adelaide, Australia
    J Eval Clin Pract 14:888-97. 2008
    ..Data sources/study setting Systematic reviews in full text, English language, 1987-2007, reporting any measure of clinical process change or cost-benefit analysis...
  80. pmc What is "quality of evidence" and why is it important to clinicians?
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8N 3Z5
    BMJ 336:995-8. 2008
  81. ncbi The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Clin Chem 49:7-18. 2003
    ..Complete and informative reporting can only lead to better decisions in healthcare...
  82. ncbi Evaluation of the quality of prognosis studies in systematic reviews
    Jill A Hayden
    Institute for Work and Health, University of Toronto, and Mount Sinai Hospital, Toronto, Ontario, Canada
    Ann Intern Med 144:427-37. 2006
    ..To provide valid assessments of answers to prognostic questions, systematic reviews must appraise the quality of the available evidence. However, no standard quality assessment method is currently available...
  83. doi Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?
    Kristian Thorlund
    Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Department 3344, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Int J Epidemiol 38:276-86. 2009
    ..e. applying trial sequential monitoring boundaries)...
  84. ncbi Toward a better understanding of the influences on physical activity: the role of determinants, correlates, causal variables, mediators, moderators, and confounders
    Adrian E Bauman
    School of Community Medicine and Public Health, University of New South Wales, Sydney, Australia
    Am J Prev Med 23:5-14. 2002
    ..This article examines the factors that are correlated with and that may have a causal relationship to physical activity...
  85. ncbi The PARIHS framework--a framework for guiding the implementation of evidence-based practice
    Jo Rycroft-Malone
    Royal College of Nursing Institute, Oxford, United Kingdom
    J Nurs Care Qual 19:297-304. 2004
  86. ncbi What makes self-help interventions effective in the management of depressive symptoms? Meta-analysis and meta-regression
    Judith Gellatly
    Department of Nursing, Midwifery and Health Visiting, University of Manchester, UK
    Psychol Med 37:1217-28. 2007
    ..e. moderators of effect). This study sought to determine whether the content of self-help interventions, the study populations or aspects of study design were the most important moderators...
  87. ncbi Good practice in the conduct and reporting of survey research
    Kate Kelley
    Research Department, Worthing and Southland Hospitals NHS Trust, Worthing, West Sussex, UK
    Int J Qual Health Care 15:261-6. 2003
    ..It is not intended to provide a manual of how to conduct a survey, but rather to identify common pitfalls and oversights to be avoided by researchers if their work is to be valid and credible...
  88. doi Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials
    Kausik K Ray
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Lancet 373:1765-72. 2009
    ..We undertook a meta-analysis of randomised controlled trials to determine whether intensive treatment is beneficial...
  89. ncbi The Australian Diabetes, Obesity and Lifestyle Study (AusDiab)--methods and response rates
    David W Dunstan
    The International Diabetes Institute, 250 Kooyong Road, Caulfield, VIC 3162, Australia
    Diabetes Res Clin Pract 57:119-29. 2002
    ..Furthermore, it generates the baseline data for a prospective 5-year cohort study. The data will be important for national and regional public health and lifestyle education and health promotion programs...
  90. doi A pragmatic-explanatory continuum indicator summary (PRECIS): a tool to help trial designers
    Kevin E Thorpe
    Dalla Lana School of Public Health, University of Toronto, Ontario, Canada
    J Clin Epidemiol 62:464-75. 2009
    ..To propose a tool to assist trialists in making design decisions that are consistent with their trial's stated purpose...
  91. doi Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality
    Malcolm R Macleod
    Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK
    Stroke 39:2824-9. 2008
    ..Animal studies are susceptible to study quality biases, which may lead to overstatement of efficacy. We report the impact of study quality on published estimates of the efficacy of NXY-059 in animal models of stroke...
  92. pmc Systematic review of the Hawthorne effect: new concepts are needed to study research participation effects
    Jim McCambridge
    Department of Social and Environmental Health, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, UK Electronic address
    J Clin Epidemiol 67:267-77. 2014
    ..This study aims to (1) elucidate whether the Hawthorne effect exists, (2) explore under what conditions, and (3) estimate the size of any such effect...
  93. ncbi Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation
    R B D'Agostino
    Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    JAMA 286:180-7. 2001
    ..Concern exists regarding whether these functions can be generalized to other populations...
  94. ncbi Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Standards for Reporting of Diagnostic Accuracy
    Patrick M Bossuyt
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Clin Chem 49:1-6. 2003
    ..To comprehend the results of diagnostic accuracy studies, readers must understand the design, conduct, analysis, and results of such studies. That goal can be achieved only through complete transparency from authors...
  95. ncbi Qualitative research: standards, challenges, and guidelines
    K Malterud
    Section for General Practice, Department of Public Health and Primary Health Care, University of Bergen, Ulriksdal 8c, N 5009, Bergen, Norway
    Lancet 358:483-8. 2001
    ....
  96. doi Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses
    Jesper Brok
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Cochrane Hepato Biliary Group, Dept 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Epidemiol 61:763-9. 2008
    ..Meta-analyses not reaching information size are analyzed with trial sequential monitoring boundaries analogous to interim monitoring boundaries in a single trial...
  97. pmc Graphical method for depicting randomised trials of complex interventions
    Rafael Perera
    Centre for Evidence Based Medicine, Department of Primary Health Care, University of Oxford, Oxford OX3 7LF
    BMJ 334:127-9. 2007
  98. pmc A worked example of "best fit" framework synthesis: a systematic review of views concerning the taking of some potential chemopreventive agents
    Christopher Carroll
    School of Health and Related Research, University of Sheffield, Sheffield, UK
    BMC Med Res Methodol 11:29. 2011
    ..The aim of this paper is to describe the application of a pragmatic method of qualitative evidence synthesis and the lessons learned from adopting this "best fit" framework synthesis approach...
  99. pmc A cluster randomised controlled trial of the community effectiveness of two interventions in rural Malawi to improve health care and to reduce maternal, newborn and infant mortality
    Sonia Lewycka
    Centre for International Health and Development, UCL Institute of Child Health, London, UK
    Trials 11:88. 2010
    ..The MaiMwana Project aims to test community-based interventions that tackle maternal and child health problems through increasing awareness and local action...
  100. pmc Randomized clinical trials with biomarkers: design issues
    Boris Freidlin
    Biometric Research Branch, EPN 8122, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Cancer Inst 102:152-60. 2010
    ..We conclude that, in most settings, randomized biomarker-stratified designs (ie, designs that use the biomarker to guide analysis but not treatment assignment) should be used to obtain a rigorous assessment of biomarker clinical utility...
  101. ncbi Research guidelines for the Delphi survey technique
    F Hasson
    Centre for Nursing Research, University of Ulster, Newtownabbey, Northern Ireland
    J Adv Nurs 32:1008-15. 2000
    ..The paper does not claim to be definitive; it purports to act as a guide for those researchers who wish to exploit the Delphi methodology...

Research Grants78

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  4. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  5. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  6. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  7. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  8. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  9. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
    ..The contractor is responsible for providing staff with the credentials required by CLIA. ..
  10. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ....
  11. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2011
    ..The Panel recommended that studies should be conducted to further characterize the in vitro test methods and that testing strategies should be designed in coordination with ICCVAM. ..
  12. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2012
    ..The Panel recommended that studies should be conducted to further characterize the in vitro test methods and that testing strategies should be designed in coordination with ICCVAM. ..
  13. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..We propose these humanized mice will be a technology platform to better understand the human disease and it will aid in the development of gene or cellular therapy to correct these devastating diseases. ..
  14. Optimization of DNA Repair by Abh8
    Lauren Endres; Fiscal Year: 2013
    ..Overall, these findings will form the basis of future studies into Abh8 regulation during the DDR. ..
  15. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..We have successfully tested one of these serpins, Serp-1, in a small phase 2A clinical trial for anti-inflammatory activity in unstable coronary syndromes (Viron Therapeutics, Inc;proprietary information). ..
  16. Vaccine Development for Falciparum Malaria in Pregnant Women and Their Offspring
    Ian C Michelow; Fiscal Year: 2013
    ..Candidate vaccine proteins will be screened, confirmed and selected for clinical trials using pioneering molecular tools and blood samples from pregnant African women and their infants. ..
  17. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..The results may lead to new drugs and interventions to improve eating behavior, and help establish unbiased indicators of obesity risk and prognosis for use in research and clinical settings. ..
  18. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..This proposal represents an essential first step in the design of a subsequent clinical trial to improve vascular function in SCD patients. ..
  19. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..In the future, individual patients with variation in these genes may benefit from targeted behavioral and/or pharmacological interventions designed to improve their health. ..
  20. Genome-wide recombination as a risk factor for nondisjunction
    NATASHA D HOLLIS; Fiscal Year: 2010
    ..The reference letters are strong. She has the necessary package to excel as a pre-doctoral fellow. ..
  21. Infant Screening and Diagnosis of Duchenne Muscular Dys*
    Paul Fernhoff; Fiscal Year: 2007
    ..These data points will be tracked throughout the project. ..
  22. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..Our data will fill in fundamental gaps in our understanding of how brain dopamine systems work. This will help researchers who study these other brain disorders. ..
  23. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..abstract_text> ..
  24. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
    ....
  25. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2013
    ..abstract_text> ..
  26. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
    ..Three aims are proposed in this application to test these hypotheses and elucidate how SAMe affects signaling pathways that are important in hepatocarcinogenesis and development of alcoholic liver injury. ..
  27. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..Thus the currently proposed studies are significant in terms of clinical implications for limiting cardiac damage in the vulnerable veteran population and for fiscal health of the Department of Veterans Affairs. ..
  28. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    CHARLES WILLIAM WILKINSON; Fiscal Year: 2012
    ..abstract_text> ..
  29. Neurobehavioral Correlates of Familial/genetic obesity risk in adolescents
    Susan Carnell; Fiscal Year: 2013
    ..abstract_text> ..
  30. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..Successful completion of the study will lead to improved health outcome of a significant number of patients by decreasing the need for indefinite use of non-specific immunosuppressants in transplant recipients. ..
  31. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ....
  32. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..Lessons learnt from understanding the role of ezrin in B cell function can be applied towards therapeutic design for B cell-dependent human diseases. ..
  33. Behavioral Activation Therapy for Rural Veterans with Diabetes and Depression
    Aanand Dinkar Naik; Fiscal Year: 2013
    ..As therapists are all advanced psychology graduate students, it is unclear whether individuals without such previous training can implement the intervention. This may hamper implementation efforts. ..
  34. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
    ..It is therefore crucial to begin establishing the mechanisms that lead to abnormal development of the brainstem neurons that regulate these critical homeostatic functions. ..
  35. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2013
    ..Joanne Jordan from the University of North Carolina who will help with clinical correlation to OA and research design. In addition to a distinguished and experienced mentoring team, Dr...
  36. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..b>Research Design and Methods: In our rodent model of cisplatin-induced cachexia we have observed that ghrelin prevents ..
  37. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..The existing resources for this secondary data analysis provide an unprecedented cost- efficient opportunity to build on established work and expand knowledge in this important area of public health. ..
  38. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2010
    ....
  39. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..Our first test of these nanoparticles will use a mouse model of bladder cancer. Thus, we can determine the therapeutic potential of siRNA for treatment of urologic diseases. ..
  40. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..The synthesis and discovery of an optimal locally active androgen antagonist to be applied to the skin to treat acne, alopecia, seborrhea (and hirsutism in women) are the subjects of this application. ..
  41. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..If successful, the health benefit will be large, as it is estimated that treating NEC alone (not including treating its later complications) adds $650 million to the annual health bill. ..
  42. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
    ..We believe the information gained from this study will lead to potentially new treatments for treating hearing loss. ..
  43. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2009
    ..NICEATM and ICCVAM will also evaluate non-animal methods and approaches for determining the skin irritation potential of antimicrobial cleaning products...
  44. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ....
  45. Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer
    Paul J Shami; Fiscal Year: 2012
    ..This new drug then goes one step further: it will improve the quality of life for cancer patients, their caregivers and families by providing a significantly more effective and less painful therapy than is currently available. ..
  46. BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINS
    Pi Wan Cheng; Fiscal Year: 2010
    ..Current studies could facilitate the development of therapy for mucus hypersecretory diseases through identification of small carbohydrate inhibitors and mucus cell-specific promoter. ..
  47. Remodeling Neuronal Chromatin in Mouse Models for Depression
    Schahram Akbarian; Fiscal Year: 2013
    ..Then, indirectly, the chromatin changes brought about by Setdb1 result in certain adaptations in the communication between nerve cells, ultimately resulting in an antidepressant-like effect. ..
  48. Targeting superbugs: discovery and development of new broad-spectrum lipopeptides
    Jian Li; Fiscal Year: 2013
    ..b>Research Design: Using a new structure-activity relationship (SAR)-based mechanistic model for polymyxins, novel lipopeptides ..
  49. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
    ....
  50. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-Lead
    CYNTHIA T MCEVOY; Fiscal Year: 2013
    ..End of Abstract) ..
  51. Prostate cancer chemoprevention by penta-galloyl-glucose
    Junxuan Lu; Fiscal Year: 2013
    ..These multiple targeting activities plus published work supporting anti- angiogenesis activity provide strong rationale for testing the efficacy of PGG for prostate cancer chemoprevention. ..
  52. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Information on the health effects of conversion to biodiesel fuels in occupational and environmental settings will also help to inform future policy decisions. ..
  53. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    FREDERIC TREMAINE BILLINGS; Fiscal Year: 2013
    ..Strong institutional investment in the candidate optimizes his likelihood of progressing to independence and impacting on adverse effects of surgery. ..
  54. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
    ..As a future independent investigator, this system will enable me to collaborate with scientists and clinicians to address a wide scope of challenges in medicine. ..
  55. Improving TB Diagnosis in Children with and without HIV in Kenya
    Rinn Song; Fiscal Year: 2013
    ....
  56. Ethanol Regulation of Serum Glucocorticoid Kinase I
    BLAIR N COSTIN; Fiscal Year: 2012
    ..The work proposed here could shed light on molecular mechanisms underlying alcoholism and eventually have implications in the development of novel pharmacological agents for alcoholism or alcohol-related neurological disorders. ..
  57. Systemic Inflammation and Central Nervous System Dysfunction
    Laura L Dugan; Fiscal Year: 2013
    ..abstract_text> ..
  58. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..This project seeks to better understand the molecular mechanisms by which these cotransporters work and how they are regulated, to improve understanding and treatment of high blood pressure and disorders of acid-base balance. ..
  59. Sex Steroid Hormone Regulation of Drug Reinforcement
    Diane Lebesgue; Fiscal Year: 2012
    ..abstract_text> ..
  60. Latin American Center for Malaria Research and Control
    SOCRATES HERRERA VALENCIA; Fiscal Year: 2013
    ..Data and findings generated by this Center are expected to provide input critical to inform future research design and evaluation of new interventions and control strategies...
  61. Targeting iNOS to inhibit myeloid-derived suppressor cells (MDSC) in melanoma
    ANDREW GREGORY SIKORA; Fiscal Year: 2013
    ..abstract_text> ..
  62. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2012
    ..This proposal aims to investigate new genes that regulate the formation and activity of osteoclasts to better understand bone biology in general, and potentially to find new ways to treat these widespread bone disorders. ..
  63. Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic Manipulations
    Petr Tvrdik; Fiscal Year: 2013
    ..We will be able to determine if Hoxb8 mutant microglia respond to neural stimuli correctly. Taken together, the proposed work will advance the set of tools available to address the underlying causes of glial and other disorders. ..
  64. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..Other applications for this technology are expected to be part of the GEI, the National Children's Study (NCS), in workplace assessments of occupational exposure, hospitals, or other medical or research settings. ..
  65. Bioconductor: an open computing resource for genomics
    Martin Morgan; Fiscal Year: 2010
    ..While that type of "success measure" is hard to assess, more effort in this area in subsequent proposals would be helpful. ..
  66. Intracellular Phase Diagram Creation Using a Micro-Differential Scanning Calorime
    GARY L SOLBREKKEN; Fiscal Year: 2010
    ..We will test the new machine on mouse oocytes, mouse and rat embryos, and zebrafish embryos. ..
  67. Integrated MRI-Based Examination for Evaluation of Peripheral Arterial Disease
    Felix W Wehrli; Fiscal Year: 2010
    ....
  68. Economic Consequences of Advanced Testing for Subclinical Cardiovascular Disease
    Leslee J Shaw; Fiscal Year: 2010
    ..We will compare costs in addition to the added benefit of improved detection of heart disease risk using several cardiac biomarkers. ..
  69. Exercise-Facilitated NeuroRehabilitation in Diabetic Neuropathy
    EVAN STUBBS; Fiscal Year: 2009
    ..With an aging Veteran population, the number of diabetic neuropathic patients in need of VA medical services is expected to increase considerably. ..
  70. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ....
  71. Novel Use of Confocal Microscopy on Cultured Porcine Corneas for Pre-Clinical Tes
    Michelle Piehl; Fiscal Year: 2011
    ..This would reduce overall product development cost and human test subject pain and distress while promoting robust product safety for public health. ..
  72. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
  73. WI State Public Health Lab Capacity for SCID Screening
    CHARLES DENNIS BROKOPP; Fiscal Year: 2010
    ..Our SCID-NBS program will not only produce essential baseline data (i.e. incidence rates in the target population), it will detect SCID afflicted newborns born in year 01 through 03. ..
  74. ATYPICAL ODONTALGIA AND ENDODONTIC TREATMENT, SENSORY TESTING AND GENETIC STUDY
    Eli Eliav; Fiscal Year: 2010
    ..This exploratory study results may serve as the ground for a further study that will evaluate more patients prior to the procedure, will study predisposing factors and will help predict treatment outcome. ..
  75. Risk of Cancer with Incidental Findings Identified on Ultrasound Imaging
    Rebecca Smith Bindman; Fiscal Year: 2010
    ..The goal is to develop management strategies for these incidental findings that will maximize the detection of occult cancer, while minimizing unnecessary imaging surveillance. ..
  76. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..The research design is a prospective observational study of ICU patients with hospital-acquired pneumonia and bloodstream ..
  77. Echinacea: Standardized Product & Supply Provision
    Xiping Wang; Fiscal Year: 2004
    ..abstract_text> ..
  78. Testing a Measurement Model of Acute Dyspnea
    Mark Parshall; Fiscal Year: 2005
    ....