Summary: The form of energy and the sensation of an increase in temperature. Its interest in medicine is largely with reference to its physiological effects, its therapeutic use, and its use in procedures in physics and physical chemistry.

Top Publications

  1. pmc Projecting heat-related mortality impacts under a changing climate in the New York City region
    Kim Knowlton
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Public Health 97:2028-34. 2007
  2. ncbi Heat stress and public health: a critical review
    R Sari Kovats
    Public and Environmental Health Research Unit PEHRU, London School of Hygiene and Tropical Medicine, London, UK
    Annu Rev Public Health 29:41-55. 2008
  3. pmc When defense pathways collide. The response of Arabidopsis to a combination of drought and heat stress
    Ludmila Rizhsky
    Department of Biology, Technion, Israel Institute of Technology, Technion City, Haifa 32000, Israel
    Plant Physiol 134:1683-96. 2004
  4. ncbi Arabidopsis heat shock transcription factor A2 as a key regulator in response to several types of environmental stress
    Ayako Nishizawa
    Department of Advanced Bioscience, Faculty of Agriculture, Kinki University, 3327 204 Nakamachi, Nara 631 8505, Japan
    Plant J 48:535-47. 2006
  5. ncbi Impact of high temperatures on mortality: is there an added heat wave effect?
    Shakoor Hajat
    London School of Hygiene and Tropical Medicine, London, UK
    Epidemiology 17:632-8. 2006
  6. ncbi A cascade of transcription factor DREB2A and heat stress transcription factor HsfA3 regulates the heat stress response of Arabidopsis
    Franziska Schramm
    Institute of Molecular Biosciences, Biocenter N200 R306, Goethe University Frankfurt, Max von Laue Str 9, D 60438 Frankfurt, Germany
    Plant J 53:264-74. 2008
  7. ncbi Heat-related mortality during a 1999 heat wave in Chicago
    Mary P Naughton
    Epidemic Intelligence Service, Epidemiology Progam Office, and the National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Prev Med 22:221-7. 2002
  8. ncbi Europe-wide reduction in primary productivity caused by the heat and drought in 2003
    Ph Ciais
    Laboratoire des Sciences du Climat et de l Environnement, LSCE, F 91191, Gif sur Yvette, France
    Nature 437:529-33. 2005
  9. pmc A heat-inducible transcription factor, HsfA2, is required for extension of acquired thermotolerance in Arabidopsis
    Yee Yung Charng
    Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan, ROC
    Plant Physiol 143:251-62. 2007
  10. pmc Heat-related and cold-related deaths in England and Wales: who is at risk?
    S Hajat
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Occup Environ Med 64:93-100. 2007

Detail Information

Publications401 found, 100 shown here

  1. pmc Projecting heat-related mortality impacts under a changing climate in the New York City region
    Kim Knowlton
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Public Health 97:2028-34. 2007
    We sought to project future impacts of climate change on summer heat-related premature deaths in the New York City metropolitan region.
  2. ncbi Heat stress and public health: a critical review
    R Sari Kovats
    Public and Environmental Health Research Unit PEHRU, London School of Hygiene and Tropical Medicine, London, UK
    Annu Rev Public Health 29:41-55. 2008
    b>Heat is an environmental and occupational hazard. The prevention of deaths in the community caused by extreme high temperatures (heat waves) is now an issue of public health concern...
  3. pmc When defense pathways collide. The response of Arabidopsis to a combination of drought and heat stress
    Ludmila Rizhsky
    Department of Biology, Technion, Israel Institute of Technology, Technion City, Haifa 32000, Israel
    Plant Physiol 134:1683-96. 2004
    ..habitat, plants are subjected to a combination of abiotic conditions that include stresses such as drought and heat. Drought and heat stress have been extensively studied; however, little is known about how their combination ..
  4. ncbi Arabidopsis heat shock transcription factor A2 as a key regulator in response to several types of environmental stress
    Ayako Nishizawa
    Department of Advanced Bioscience, Faculty of Agriculture, Kinki University, 3327 204 Nakamachi, Nara 631 8505, Japan
    Plant J 48:535-47. 2006
    We isolated 76 high-light and heat-shock (HL + HS) stress-inducible genes, including a putative heat-shock transcription factor (HsfA2), by suppression-subtractive hybridization from Arabidopsis...
  5. ncbi Impact of high temperatures on mortality: is there an added heat wave effect?
    Shakoor Hajat
    London School of Hygiene and Tropical Medicine, London, UK
    Epidemiology 17:632-8. 2006
    ..However, the evidence for an effect of continuous days of exceptional heat ("heat wave effect") is indirect...
  6. ncbi A cascade of transcription factor DREB2A and heat stress transcription factor HsfA3 regulates the heat stress response of Arabidopsis
    Franziska Schramm
    Institute of Molecular Biosciences, Biocenter N200 R306, Goethe University Frankfurt, Max von Laue Str 9, D 60438 Frankfurt, Germany
    Plant J 53:264-74. 2008
    ..Recently it was demonstrated that DREB2A is induced by heat stress (hs) and is a regulator of the hs response of Arabidopsis...
  7. ncbi Heat-related mortality during a 1999 heat wave in Chicago
    Mary P Naughton
    Epidemic Intelligence Service, Epidemiology Progam Office, and the National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Prev Med 22:221-7. 2002
    During the summer of 1999, Chicago's second deadliest heat wave of the decade resulted in at least 80 deaths...
  8. ncbi Europe-wide reduction in primary productivity caused by the heat and drought in 2003
    Ph Ciais
    Laboratoire des Sciences du Climat et de l Environnement, LSCE, F 91191, Gif sur Yvette, France
    Nature 437:529-33. 2005
    ..that productivity reduction in eastern and western Europe can be explained by rainfall deficit and extreme summer heat, respectively...
  9. pmc A heat-inducible transcription factor, HsfA2, is required for extension of acquired thermotolerance in Arabidopsis
    Yee Yung Charng
    Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan, ROC
    Plant Physiol 143:251-62. 2007
    The expression of heat shock proteins (Hsps) induced by nonlethal heat treatment confers acquired thermotolerance (AT) to organisms against subsequent challenges of otherwise lethal temperature...
  10. pmc Heat-related and cold-related deaths in England and Wales: who is at risk?
    S Hajat
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Occup Environ Med 64:93-100. 2007
    ..Despite the high burden from exposure to both hot and cold weather each year in England and Wales, there has been relatively little investigation on who is most at risk, resulting in uncertainties in informing government interventions...
  11. pmc Contrasting patterns of mortality and hospital admissions during hot weather and heat waves in Greater London, UK
    R S Kovats
    Public and Environmental Health Research Unit, Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Occup Environ Med 61:893-8. 2004
    Epidemiological research has shown that mortality increases during hot weather and heat waves, but little is known about the effect on non-fatal outcomes in the UK.
  12. ncbi Prognostic factors in heat wave related deaths: a meta-analysis
    Abderrezak Bouchama
    Department of Comparative Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Arch Intern Med 167:2170-6. 2007
    Although identifying individuals who are at increased risk of dying during heat waves and instituting protective measures represent an established strategy, the evidence supporting the components of this strategy and their strengths has ..
  13. ncbi Impaired exercise performance in the heat is associated with an anticipatory reduction in skeletal muscle recruitment
    Ross Tucker
    MRC UCT Bioenergetics of Exercise Research Unit, University of Cape Town, Sports Science Institute of South Africa, PO Box 115, 7725, Newlands, South Africa
    Pflugers Arch 448:422-30. 2004
    Exercise in the heat causes "central fatigue", associated with reduced skeletal muscle recruitment during sustained isometric contractions. A similar mechanism may cause fatigue during prolonged dynamic exercise in the heat...
  14. ncbi Modifiers of the temperature and mortality association in seven US cities
    Marie S O'Neill
    Environmental Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 157:1074-82. 2003
    This paper examines effect modification of heat- and cold-related mortality in seven US cities in 1986-1993...
  15. pmc The combined effect of drought stress and heat shock on gene expression in tobacco
    Ludmila Rizhsky
    Department of Biology, Technion Israel Institute of Technology, Technion City, Haifa 32000, Israel
    Plant Physiol 130:1143-51. 2002
    In nature, plants encounter a combination of environmental conditions that may include stresses such as drought or heat shock...
  16. ncbi Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H2O2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats
    Qiong Luo
    College of Public Health, Wuhan University, Wuhan 430071, Hubei, PR China
    Life Sci 79:613-21. 2006
    ..barbarum polysaccharides (LBP) on rat testis damage induced by a physical factor (43 degrees C heat exposure), on DNA damage of mouse testicular cells induced by a chemical factor (H2O2), and on sexual behavior and ..
  17. ncbi Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging
    J C W Brooks
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Neuroimage 27:201-9. 2005
    ..037). Based on single subject analyses, the average standard space (MNI) coordinates for face, hand and foot activity were (-40,-16,11), (-40,-19,14) and (-35,-21,11) respectively...
  18. doi Caffeine effects on short-term performance during prolonged exercise in the heat
    Juan Del Coso
    Universidad de Castilla La Mancha, Toledo, Spain
    Med Sci Sports Exerc 40:744-51. 2008
    To determine the effect of water, carbohydrate, and caffeine ingestion on fatigue during prolonged exercise in the heat.
  19. ncbi The heat stress transcription factor HsfA2 serves as a regulatory amplifier of a subset of genes in the heat stress response in Arabidopsis
    Franziska Schramm
    Institute of Molecular Bio Sciences, Biocenter N200 R306, Goethe University, Marie Curie Str 9, D 60439, Frankfurt, Germany
    Plant Mol Biol 60:759-72. 2006
    Within the Arabidopsis family of 21 heat stress transcription factors (Hsfs) HsfA2 is the strongest expressed member under heat stress (hs) conditions...
  20. pmc Dual function of an Arabidopsis transcription factor DREB2A in water-stress-responsive and heat-stress-responsive gene expression
    Yoh Sakuma
    Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 103:18822-7. 2006
    ..CA and found that the overexpression of DREB2A CA induces not only drought- and salt-responsive genes but also heat-shock (HS)-related genes...
  21. pmc Protection against heat stress-induced oxidative damage in Arabidopsis involves calcium, abscisic acid, ethylene, and salicylic acid
    Jane Larkindale
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, United Kingdom
    Plant Physiol 128:682-95. 2002
    ..the involvement of calcium, abscisic acid (ABA), ethylene, and salicylic acid (SA) in the protection against heat-induced oxidative damage in Arabidopsis...
  22. pmc In the complex family of heat stress transcription factors, HsfA1 has a unique role as master regulator of thermotolerance in tomato
    Shravan Kumar Mishra
    Biocenter of the Goethe University, D 60439 Frankfurt am Main, Germany
    Genes Dev 16:1555-67. 2002
    We generated transgenic tomato plants with altered expression of heat stress transcription factor HsfA1...
  23. ncbi Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages
    Baochong Gao
    Institute for Clinical Research and Veterans Affairs Medical Center, Washington, DC 20422, USA
    J Biol Chem 278:174-9. 2003
    Using commercially available recombinant human heat shock protein 70 (rhHsp70), recent studies have shown that rhHsp70 could induce the production of tumor necrosis factor alpha (TNFalpha) by macrophages and monocytes in a manner similar ..
  24. pmc Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance
    Jane Larkindale
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, USA
    Plant Physiol 138:882-97. 2005
    To investigate the importance of different processes to heat stress tolerance, 45 Arabidopsis (Arabidopsis thaliana) mutants and one transgenic line were tested for basal and acquired thermotolerance at different stages of growth...
  25. ncbi A reliable method for the preferential activation of C- or A-fibre heat nociceptors
    Simon McMullan
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Neurosci Methods 138:133-9. 2004
    ..A copper disk (diameter: 4mm) was used to transfer heat evenly across the dorsal surface of the rat hindpaw...
  26. ncbi Sensitive and inexpensive molecular test for falciparum malaria: detecting Plasmodium falciparum DNA directly from heat-treated blood by loop-mediated isothermal amplification
    Leo L M Poon
    Department of Microbiology, The University of Hong Kong, Hong Kong SAR
    Clin Chem 52:303-6. 2006
    ..The aim of the present work was to develop a simple, inexpensive molecular test for Plasmodium falciparum...
  27. pmc The impact of major heat waves on all-cause and cause-specific mortality in France from 1971 to 2003
    Grégoire Rey
    Univ Paris Sud, UMR S754, IFR69, Villejuif, France and INSERM, U754, 16, avenue Paul Vaillant Couturier, 94800, Villejuif Cedex, France
    Int Arch Occup Environ Health 80:615-26. 2007
    The aim of the study was to identify the major heat waves (HW) that occurred in France from 1971 to 2003 and describe their impact on all-cause and cause-specific mortality.
  28. pmc The cardiovascular challenge of exercising in the heat
    Jose Gonzalez-Alonso
    Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, Middlesex, UK
    J Physiol 586:45-53. 2008
    Exercise in the heat can pose a severe challenge to human cardiovascular control, and thus the provision of oxygen to exercising muscles and vital organs, because of enhanced thermoregulatory demand for skin blood flow coupled with ..
  29. ncbi Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin
    Aziz Moqrich
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 307:1468-72. 2005
    ..TRPV3 is activated by heat (>33 degrees C) and, unlike most thermoTRPs, is expressed in mouse keratinocytes...
  30. pmc Core body temperature during competition in the heat: National Boys' 14s Junior Championships
    Michael F Bergeron
    Environmental Physiology Laboratory, Medical College of Georgia, Augusta, Georgia 30912, USA
    Br J Sports Med 41:779-83. 2007
    ..To examine on-court core body temperature (T(C)) and sweat loss, as well as pre- and post-play hydration status, in elite adolescent tennis players during a national championships event in a hot climate...
  31. ncbi CHIP interacts with heat shock factor 1 during heat stress
    Soo A Kim
    Oral Biology Research Institute, Chosun University College of Dentistry, 375 Seosuk dong, Dong Gu, Gwangju 501 759, Republic of Korea
    FEBS Lett 579:6559-63. 2005
    b>Heat shock factor 1 (HSF1) is a major transactivator of heat shock genes in response to stress and mediates cell protection against various harmful conditions...
  32. pmc Detection of murine norovirus 1 by using plaque assay, transfection assay, and real-time reverse transcription-PCR before and after heat exposure
    Leen Baert
    Ghent University, Faculty of Bioscience Engineering, Department of Food Safety and Food Quality, Laboratory of Food Microbiology and Food Preservation, Coupure Links 653, 9000 Ghent, Belgium
    Appl Environ Microbiol 74:543-6. 2008
    ..murine norovirus 1 RNA by real-time reverse transcription-PCR and the infectivity by plaque assay before and after heat exposure (80 degrees C) was examined. No correlation was found in the current study...
  33. ncbi Effects of purple sweet potato anthocyanins on development and intracellular redox status of bovine preimplantation embryos exposed to heat shock
    Miki Sakatani
    National Agricultural Research Center for Kyushu Okinawa Region, Japan
    J Reprod Dev 53:605-14. 2007
    The development of cleavage stage preimplantation embryos is disrupted by exposure to heat shock, such as high temperatures in the summer season...
  34. pmc Laminar organization of spinal dorsal horn neurones activated by C- vs. A-heat nociceptors and their descending control from the periaqueductal grey in the rat
    Stella Koutsikou
    Department of Physiology, School of Medical Sciences, University Walk, University of Bristol, UK
    Eur J Neurosci 26:943-52. 2007
    ..of neurones expressing Fos-like immunoreactivity were determined following preferential activation of A- or C-heat nociceptors, using fast or slow rates of skin heating, respectively, in the absence or presence of descending ..
  35. pmc Influence of brain catecholamines on the development of fatigue in exercising rats in the heat
    Hiroshi Hasegawa
    Laboratoruy of Exercise Physiology, Graduate School of Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Japan
    J Physiol 586:141-9. 2008
    ..and neurotransmitters in the preoptic area and anterior hypothalamus (PO/AH) of the rat during exercise in the heat. Body core temperature (T(core)), brain temperature (T(brain)) and tail skin temperature (T(tail)) were measured...
  36. doi Increased cause-specific mortality associated with 2003 heat wave in Essen, Germany
    Barbara Hoffmann
    Institute for Medical Informatics, Biometry and Epidemiology, University Hospital, University of Duisburg Essen, Essen, Germany
    J Toxicol Environ Health A 71:759-65. 2008
    During the 2003 heat wave an increase in mortality was observed in several European countries. Evidence suggests that the heat wave effect on mortality varies based upon underlying disease...
  37. ncbi Study on the hydroxyl radical scavenging activity changes of ginseng and ginsenoside-Rb2 by heat processing
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, Japan
    Biol Pharm Bull 30:724-8. 2007
    The free radical scavenging activities of Panax ginseng C.A. MEYER are known to increase by heat processing...
  38. ncbi Increase in the free radical scavenging activity of ginseng by heat-processing
    Ki Sung Kang
    Institute of Natural Medicine, University of Toyama, Sugitani, Japan
    Biol Pharm Bull 29:750-4. 2006
    To investigate whether or not the radical scavenging activity of ginseng is enhanced by heat processing, we evaluated the scavenging effects of white ginseng (WG), red ginseng (RG, steamed ginseng at 98-100 degrees C) and sun ginseng (SG, ..
  39. ncbi 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3
    Man Kyo Chung
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:5177-82. 2004
    ..2-APB also sensitizes TRPV3 to activation by heat, even at subthreshold concentrations...
  40. pmc NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels
    Xuming Zhang
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    EMBO J 24:4211-23. 2005
    ..by a variety of proinflammatory factors, including bradykinin, ATP and NGF, which cause sensitization to noxious heat stimuli by enhancing the membrane current carried by the heat- and capsaicin-gated ion channel, TRPV1...
  41. ncbi Opposite changes in membrane fluidity mimic cold and heat stress activation of distinct plant MAP kinase pathways
    Veena Sangwan
    Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montreal, Quebec, H3A 1B1, Canada
    Plant J 31:629-38. 2002
    ..In plants, no heat shock-activated MAPK has so far been reported...
  42. ncbi Proteasome inhibition increases HuR level, restores heat-inducible HSP72 expression and thermotolerance in WI-38 senescent human fibroblasts
    Mara A Bonelli
    Sezione di Patologia Molecolare e Immunologia, Dipartimento di Medicina Sperimentale, Universita degli Studi di Parma, Via Volturno 39, 43100 Parma, Italy
    Exp Gerontol 39:423-32. 2004
    ..replicative potential in vitro, late passage WI-38 human diploid fibroblasts (HDF) have a low basal expression of heat shock protein 72 (HSP72) and an attenuated ability to induce it in response to heat shock...
  43. ncbi Induction of heat shock proteins in B-cell exosomes
    Aled Clayton
    Department of Clinical Oncology and Palliative Medicine, Wales College of Medicine, Cardiff University, Velindre Cancer Centre, Whitchurch, Cardiff, CF14 2TL, UK
    J Cell Sci 118:3631-8. 2005
    ..Exposing cells to heat stress (42 degrees C for up to 3 hours), resulted in a marked increase in these heat shock proteins (hsps), while ..
  44. ncbi Aggregation-resistant domain antibodies selected on phage by heat denaturation
    Laurent Jespers
    Nat Biotechnol 22:1161-5. 2004
    We describe a method for selecting aggregation-resistant proteins by heat denaturation. This is illustrated with antibody heavy chain variable domains (dAbs), which are prone to aggregate...
  45. ncbi A proteomic approach in analyzing heat-responsive proteins in rice leaves
    Dong Gi Lee
    Division of Applied Life Sciences BK21 and EB NCRC, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju, Korea
    Proteomics 7:3369-83. 2007
    The present study investigated rice leaf proteome in response to heat stress. Rice seedlings were subjected to a temperature of 42 degrees C and samples were collected 12 and 24 h after treatment...
  46. pmc Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks
    Cecilia Lundin
    Department of Genetics, Microbiology and Toxicology, Stockholm University Svante Arrhenius väg 16, S 106 91 Stockholm, Sweden
    Nucleic Acids Res 33:3799-811. 2005
    ..Instead, DSBs seen following MMS treatment are produced during sample preparation where heat-labile methylated DNA is converted into DSBs...
  47. pmc Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72
    Maria A Bausero
    Center for Molecular Stress Response, Boston University Medical Center and Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 175:2900-12. 2005
  48. ncbi Persistent protective effect of heat-killed Escherichia coli producing "engineered," recombinant peanut proteins in a murine model of peanut allergy
    Xiu Min Li
    Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 112:159-67. 2003
    ..Peanut allergy (PNA) is a life-threatening food allergy for which there is no definitive treatment...
  49. ncbi Heat induction of the unphosphorylated form of hypoxia-inducible factor-1alpha is dependent on heat shock protein-90 activity
    Dorthe M Katschinski
    Institute of Physiology and Department of Anaesthesiology, Medical University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    J Biol Chem 277:9262-7. 2002
    ..b>Heat was sufficient to stabilize mainly a phosphatase-resistant, low molecular weight form of HIF-1alpha (termed HIF-..
  50. ncbi Reduced heat sensitivity and epidermal nerve fiber immunostaining following single applications of a high-concentration capsaicin patch
    Annika B Malmberg
    NeurogesX, Inc, 981F Industrial Road, San Carlos, CA 94070, USA
    Pain 111:360-7. 2004
    ..Seven days following patch application, changes in heat and cold perception thresholds were determined by quantitative sensory testing and punch biopsies were collected to ..
  51. ncbi Fungicidal effects of chemical disinfectants, UV light, desiccation and heat on the amphibian chytrid Batrachochytrium dendrobatidis
    Megan L Johnson
    School of Public Health and Tropical Medicine, James Cook University, Townsville, Queensland 4810, Australia
    Dis Aquat Organ 57:255-60. 2003
    ..The aim was to evaluate the fungicidal effects of chemical disinfectants, sterilising ultraviolet (UV) light, heat and desiccation, using methods that were feasible for either disinfection in the field, in amphibian husbandry or ..
  52. ncbi In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis
    Shine Tu
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA
    Nat Cell Biol 8:72-7. 2006
    ..Caspase-2 was exclusively activated in heat shock-induced apoptosis...
  53. ncbi Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease
    Todd R Flower
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    J Mol Biol 351:1081-100. 2005
    ..A brief heat shock was strikingly protective in that alpha-syn-expressing cells receiving a heat shock exhibited none of these ..
  54. ncbi Insulin signaling and the heat shock response modulate protein homeostasis in the Caenorhabditis elegans intestine during infection
    Akiko Mohri-Shiomi
    Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, 6431 Fannin Street, Houston, TX 77030, USA
    J Biol Chem 283:194-201. 2008
    ..We demonstrate that the insulin signaling pathway and the heat shock transcription factor (HSF-1) influence the amount of aggregation that occurs, in addition to heat shock ..
  55. ncbi Developments in industrially important thermostable enzymes: a review
    G D Haki
    Bioprocess Technology Program, Asian Institute of Technology, P O Box 4, Klong Luang, Pathumthani 12120, Thailand
    Bioresour Technol 89:17-34. 2003
    ..The industrial needs for such specific thermostable enzyme and improvements required to maximize their application in the future are also suggested...
  56. pmc Spinal dorsal horn neuronal responses to myelinated versus unmyelinated heat nociceptors and their modulation by activation of the periaqueductal grey in the rat
    Simon McMullan
    Hypertension and Stroke Research Laboratory, Royal North Shore Hospital, St Leonards, Sydney, NSW 2065, Australia
    J Physiol 576:547-56. 2006
    ..the response characteristics of Class 2 dorsal horn neurones to preferential activation of C- and A-fibre heat nociceptors, and (ii) investigating the control exerted by the dorsolateral/lateral region of the midbrain ..
  57. pmc Extreme heat reduces and shifts United States premium wine production in the 21st century
    M A White
    Watershed Sciences, Utah State University, 5210 Old Main Hill, Logan, UT 84322, USA
    Proc Natl Acad Sci U S A 103:11217-22. 2006
    ..Three central climatic conditions are required: (i) adequate heat accumulation; (ii) low risk of severe frost damage; and (iii) the absence of extreme heat...
  58. pmc Changing heat-related mortality in the United States
    Robert E Davis
    Department of Environmental Sciences, University of Virginia, Charlottesville, Virginia 22904 4123, USA
    Environ Health Perspect 111:1712-8. 2003
    b>Heat is the primary weather-related cause of death in the United States. Increasing heat and humidity, at least partially related to anthropogenic climate change, suggest that a long-term increase in heat-related mortality could occur...
  59. ncbi Physiological responses of forest trees to heat and drought
    H Rennenberg
    Institute of Forest Botany and Tree Physiology, Chair of Tree Physiology, Albert Ludwigs University Freiburg, Georges Köhler Allee 53 54, 79110 Freiburg, Germany
    Plant Biol (Stuttg) 8:556-71. 2006
    The heat wave of summer 2003 was the largest and the most persistent ever experienced in Central Europe and has fuelled concern about the effects of climate change on European ecosystems...
  60. doi Infrared plus visible light and heat from natural sunlight participate in the expression of MMPs and type I procollagen as well as infiltration of inflammatory cell in human skin in vivo
    Soyun Cho
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Dermatol Sci 50:123-33. 2008
    ..Compared with the detailed characterization of the ultraviolet (UV) response in human skin, the effects of infrared (IR) and other regions of the sunlight are scarce...
  61. pmc Facile generation of heat-stable antiviral and antitoxin single domain antibodies from a semisynthetic llama library
    Ellen R Goldman
    Center for Bio Molecular Science and Engineering, US Naval Research Laboratory, Washington, DC 20375, USA
    Anal Chem 78:8245-55. 2006
    ..The ability to rapidly select such rugged antibodies will enhance the reliability of immunoassays by extending shelf life and the capacity to function in hostile environments...
  62. pmc Galactinol synthase1. A novel heat shock factor target gene responsible for heat-induced synthesis of raffinose family oligosaccharides in Arabidopsis
    Tressa Jacob Panikulangara
    Zentrum für Molekularbiologie der Pflanzen, Allgemeine Genetik, Universitat Tubingen, D 72076 Tubingen, Germany
    Plant Physiol 136:3148-58. 2004
    b>Heat shock factors (HSFs) are transcriptional regulators of the heat shock response...
  63. pmc Heat-induced formation of reactive oxygen species and 8-oxoguanine, a biomarker of damage to DNA
    Vadim I Bruskov
    Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290 Russian Federation
    Nucleic Acids Res 30:1354-63. 2002
    b>Heat-induced formation of 8-oxoguanine was demonstrated in DNA solutions in 10(-3) M phosphate buffer, pH 6.8, by enzyme-linked immunosorbent assays using monoclonal antibodies against 8-oxoguanine. A radiation-chemical yield of 3...
  64. ncbi Spermatocyte-specific expression of constitutively active heat shock factor 1 induces HSP70i-resistant apoptosis in male germ cells
    N Vydra
    Department of Tumor Biology, Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, 44 101 Gliwice, Poland
    Cell Death Differ 13:212-22. 2006
    Spermatocytes, the most sensitive male germ cells to heat-induced apoptosis, do not respond to hyperthermia by inducing heat shock proteins (HSPs), including HSP70i, which has been previously shown to confer resistance to apoptosis in ..
  65. ncbi Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold
    Christopher M Elitt
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 26:8578-87. 2006
    ..properties using an ex vivo preparation showed that cutaneous C-fiber nociceptors of ART-OE mice had reduced heat thresholds and increased firing rates in response to a heat ramp. No change in mechanical threshold was detected...
  66. pmc GFR alpha2/neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neurons
    Cheryl L Stucky
    Growth Factors and Regeneration Group, Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, Berlin D 13092, Germany
    J Physiol 545:43-50. 2002
    ..Because 50 % of IB(4)-binding neurons respond to noxious heat and because patch clamp recordings of isolated dorsal root ganglion sensory neurons allow one to neurochemically ..
  67. ncbi Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes
    Zhuoyu Ni
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Mol Cell 13:55-65. 2004
    ..not Ser5--phosphorylated CTD at actively transcribed loci on Drosophila polytene chromosomes under both normal and heat shocked conditions...
  68. doi Structural dynamics of archaeal small heat shock proteins
    Martin Haslbeck
    Munich Center for Integrated Protein Science CIPSM, Technische Universitat Munchen, Department Chemistry, Lichtenbergstr 4, 85747 Garching, Germany
    J Mol Biol 378:362-74. 2008
    Small heat shock proteins (sHsps) are a widespread and diverse class of molecular chaperones. In vivo, sHsps contribute to thermotolerance...
  69. ncbi Heat acclimation and cross-tolerance against novel stressors: genomic-physiological linkage
    Michal Horowitz
    Laboratory of Environmental Physiology, The Hebrew University, POB 12272, Jerusalem 91120, Israel
    Prog Brain Res 162:373-92. 2007
    b>Heat acclimation (AC) is a "within lifetime" reversible phenotypic adaptation, enhancing thermotolerance and heat endurance via a transition to "efficient" cellular performance when acclimatory homeostasis is reached...
  70. ncbi Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway
    Kate Petersen Shay
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4234, USA
    Mol Cancer Res 3:170-81. 2005
    ..was therefore of interest to understand to what extent maintenance and degradation of Pim-1 protein is affected by heat shock proteins (Hsp) and the ubiquitin-proteasome pathway in K562 and BV173 human leukemic cells...
  71. ncbi Hormetic effects of repeated exposures to cold at young age on longevity, aging and resistance to heat or cold shocks in Drosophila melanogaster
    Eric Le Bourg
    Centre de Recherche sur la Cognition Animale, UMR CNRS 5169, Universite Paul Sabatier, 118 route de Narbonne, 31062, Toulouse Cedex 9, France
    Biogerontology 8:431-44. 2007
    Exposing young flies to hypergravity has hormetic effects on aging, longevity and resistance to heat stress. The present experiments tested whether cold shocks at young age could also have hormetic effects...
  72. ncbi The cellular response to heat stress in the goby Gillichthys mirabilis: a cDNA microarray and protein-level analysis
    Bradley A Buckley
    Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA
    J Exp Biol 209:2660-77. 2006
    ..and white muscle tissues of a eurythermic fish, Gillichthys mirabilis (Gobiidae) exposed to ecologically relevant heat stress. In each tissue, the induction or repression of over 200 genes was observed...
  73. ncbi Chlororespiration is involved in the adaptation of Brassica plants to heat and high light intensity
    Milagros Díaz
    Departamento de Biologia Vegetal, Facultad de Biologia, Universidad de Murcia, Campus de Espinardo, E 30100 Murcia, Spain
    Plant Cell Environ 30:1578-85. 2007
    Two species of Brassica were used to study their acclimation to heat and high illumination during the first stages of development...
  74. ncbi Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus
    Guillermo H Giambartolomei
    Instituto de Estudios de la Inmunidad Humoral Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    J Immunol 173:4635-42. 2004
    ..We examined the mechanism whereby heat-killed B. abortus (HKBA), as well as its LPS, induces production of inflammatory cytokines in monocytes/macrophages...
  75. ncbi Influence of genital heat stress on semen quality in humans
    A Jung
    Center of Dermatology and Andrology, Justus Liebig University, Giessen, Germany
    Andrologia 39:203-15. 2007
    ..Here, current knowledge concerning genital heat stress and its consequences in men is reviewed...
  76. pmc Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots
    Chong Zhi Wang
    Tang Center for Herbal Medicine Research, University of Chicago, Chicago, Illinois 60637, USA
    Planta Med 73:669-74. 2007
    ..b>Heat-processing increased the antiproliferative effect of American ginseng significantly, and the activity of the ..
  77. pmc Heat shock protein 70 is related to thermal inhibition of nuclear export of the influenza virus ribonucleoprotein complex
    Etsuko Hirayama
    Institute of Molecular and Cellular Biology for Pharmaceutical Sciences, Kyoto Pharmaceutical University, 1, Shichonocho, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    J Virol 78:1263-70. 2004
    ..The potential of heat shock protein 70 (HSP70) as a candidate obstructive protein was investigated...
  78. ncbi A Cochrane review of superficial heat or cold for low back pain
    Simon D French
    Australasian Cochrane Centre, Monash Institute of Health Services Research, Monash University, Clayton, Victoria, Australia
    Spine (Phila Pa 1976) 31:998-1006. 2006
    ..Cochrane systematic review...
  79. ncbi Specific expression of antimicrobial peptide and HSP70 genes in response to heat-shock and several bacterial challenges in mussels
    Cinzia Cellura
    Pathogens and Immunity, UMR CNRS EcoLag, University of Montpellier 2, CC 093, Place E Bataillon, 34095 Montpellier Cedex 05, France
    Fish Shellfish Immunol 22:340-50. 2007
    ..were challenged in vivo with either Vibrio splendidus LGP32, Vibrio anguillarum, Micrococcus lysodeikticus or by heat shock...
  80. ncbi Glutamine protects articular chondrocytes from heat stress and NO-induced apoptosis with HSP70 expression
    H Tonomura
    Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
    Osteoarthritis Cartilage 14:545-53. 2006
    To investigate the effect of l-glutamine (Gln) on stress responses of chondrocytes exposed to heat stress or nitric oxide (NO).
  81. ncbi Spores of Bacillus subtilis: their resistance to and killing by radiation, heat and chemicals
    P Setlow
    Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, 06030 3305, USA
    J Appl Microbiol 101:514-25. 2006
    A number of mechanisms are responsible for the resistance of spores of Bacillus species to heat, radiation and chemicals and for spore killing by these agents...
  82. pmc Effect of resiniferatoxin on the noxious heat threshold temperature in the rat: a novel heat allodynia model sensitive to analgesics
    Róbert Almási
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Neuropharmacology Research Group of the Hungarian Academy of Sciences, University of Pecs, Szigeti u 12, H 7624 Pecs, Hungary
    Br J Pharmacol 139:49-58. 2003
    1. An increasing-temperature hot plate (ITHP) was introduced to measure the noxious heat threshold (45.3+/-0.3 degrees C) of unrestrained rats, which was reproducible upon repeated determinations at intervals of 5 or 30 min or 1 day. 2...
  83. ncbi The diversity of plant heat stress transcription factors
    Pascal von Koskull-Döring
    Department of Molecular Cell Biology, J W Goethe University, Biocenter, Max von Laue Str 9, D 60438 Frankfurt am Main, Germany
    Trends Plant Sci 12:452-7. 2007
    Compared with other eukaryotes with one to three heat stress transcription factors (Hsf), the plant Hsf family shows a striking multiplicity, with more than 20 members...
  84. pmc Mortality and temperature in Sofia and London
    S Pattenden
    London School of Hygiene and Tropical Medicine, London, UK
    J Epidemiol Community Health 57:628-33. 2003
    b>Heat and cold have been associated with increased mortality, independently of seasonal trends, but details are little known...
  85. ncbi The effect of drought and heat stress on reproductive processes in cereals
    Beáta Barnabás
    Agricultural Research Institute of the Hungarian Academy of Sciences, Brunszvik 2, H 2462 Martonvásár, Hungary
    Plant Cell Environ 31:11-38. 2008
    ..Here we attempt to summarize the currently available information on cereal reproduction under drought and heat stress and to give an outlook towards potential strategies to improve yield safety in cereals.
  86. pmc Pattern and determinants of hospitalization during heat waves: an ecologic study
    Giuseppe Mastrangelo
    Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy
    BMC Public Health 7:200. 2007
    Numerous studies have investigated mortality during a heatwave, while few have quantified heat associated morbidity...
  87. pmc Genomic and proteomic adaptations to growth at high temperature
    Donal A Hickey
    Department of Biology, Concordia University, 7141 Sherbrooke Street, Montreal, Quebec, H4B 1R6, Canada
    Genome Biol 5:117. 2004
    ..We review the evidence for direct temperature-dependent natural selection acting on genomes, transcriptomes and proteomes...
  88. ncbi Exogenous carbohydrate oxidation rates are elevated after combined ingestion of glucose and fructose during exercise in the heat
    Roy L P G Jentjens
    Human Performance Labaratory, School of Sport and Exercise Sciences, Univ of Birmingham, Edgbaston, B15 2TT, Birmingham, UK
    J Appl Physiol 100:807-16. 2006
    ..in a higher exogenous carbohydrate (CHO) oxidation rate and a higher fluid availability during exercise in the heat compared with an isoenergetic GLU beverage...
  89. pmc RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice
    William J Durham
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 133:53-65. 2008
    ..We propose a feed-forward cyclic mechanism that increases the temperature sensitivity of RyR1 activation and underlies heat stroke and sudden death. The cycle eventually produces a myopathy with damaged mitochondria.
  90. ncbi Mitochondria-dependent pathway is involved in heat-induced male germ cell death: lessons from mutant mice
    Yanira Vera
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Research and Education Institute, Torrance, California 90509, USA
    Biol Reprod 70:1534-40. 2004
    ..In a recent study, we have shown the involvement of the mitochondria-dependent apoptotic pathway in heat-induced male germ cell apoptosis in the rat...
  91. ncbi The mRNA of the Arabidopsis gene FT moves from leaf to shoot apex and induces flowering
    Tao Huang
    Umea Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, S 90183, Umea, Sweden
    Science 309:1694-6. 2005
    ..The FT messenger RNA is transported to the shoot apex, where downstream genes are activated. These data suggest that the FT mRNA is an important component of the elusive "florigen" signal that moves from leaf to shoot apex...
  92. ncbi Heat-killed cells of lactobacilli skew the immune response toward T helper 1 polarization in mouse splenocytes and dendritic cell-treated T cells
    Lisa Chuang
    Department of Food Science and Biotechnology, National Chung Hsing University, and Department of Medical Education and Research, Taichung Veterans General Hospital, Taiwan
    J Agric Food Chem 55:11080-6. 2007
    ..focused on the immunomodulatory effects of viable cells of lactic acid bacteria; however, we investigated those of heat-killed cells of lactic acid bacteria in this study...
  93. ncbi Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy
    B Shim
    Brain Research Institute, Brain Korea 21 Project for Medical Science, and Department of Physiology, Yonsei University College of Medicine, C P O Box 8044, 120 752, Seoul, South Korea
    Neuroscience 132:193-201. 2005
    ..The afferent fibers responsive to heat stimuli were all C-fibers, and none were Adelta-fibers...
  94. ncbi Expression pattern and regulation of heme oxygenase-1/heat shock protein 32 in human liver cells
    Inge Bauer
    Department of Anesthesiology, University of the Saarland, D 66421 Homburg, Germany
    Shock 20:116-22. 2003
    ..HO-1) is a stress response protein that is highly inducible under various conditions, such as oxidative or heat stress. The present study investigated expression pattern and regulation of HO-1 in human liver...
  95. ncbi Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse
    Mihail G Chelu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    FASEB J 20:329-30. 2006
    ..experiencing whole body contractions and elevated core temperatures in response to isoflurane exposure or heat stress...
  96. ncbi Quality control of photosystem II. Cleavage of reaction center D1 protein in spinach thylakoids by FtsH protease under moderate heat stress
    Miho Yoshioka
    Graduate School of Natural Science and Technology, Okayama University, Okayama 700 8530, Japan
    J Biol Chem 281:21660-9. 2006
    When spinach thylakoids were subjected to moderate heat stress (40 degrees C for 30 min), oxygen evolution was inhibited, and cleavage of the reaction center-binding protein D1 of photosystem II took place, producing 23-kDa N-terminal ..
  97. ncbi Effect of heat treatment on the antioxidant activity of extracts from citrus peels
    Seok Moon Jeong
    Department of Food and Biotechnology, Kyungnam University, Masan 631 701, Korea
    J Agric Food Chem 52:3389-93. 2004
    The effect of heat treatment on the antioxidant activity of extracts from Citrus unshiu peels was evaluated. Citrus peels (CP) (5 g) were placed in Pyrex Petri dishes (8...
  98. doi Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model
    Cristina E Constantin
    Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University, 6020 Innsbruck, Austria
    J Neurosci 28:5072-81. 2008
    ..We show that the experimental tumor-induced heat hyperalgesia and nociceptor sensitization were prevented by systemic treatment with the tumor necrosis factor alpha ..
  99. pmc Proteome profiling of Populus euphratica Oliv. upon heat stress
    Silvia Ferreira
    Unit of Molecular Biology and Plant Biotechnology, Institute of Applied Science and Technology, Science Faculty of Lisbon University, Campo Grande, 1749 016 Lisbon, Portugal
    Ann Bot 98:361-77. 2006
    ..It is able to survive extreme temperatures, drought and salt stress, marking itself out as an important plant species to study the mechanisms responsible for survival of woody plants under heat stress.
  100. ncbi Proteomic analysis of the effect of heat stress on hexaploid wheat grain: characterization of heat-responsive proteins from non-prolamins fraction
    Thouraya Majoul
    Laboratoire de Biochimie des Proteines, Departement de Biologie, Faculte des Sciences de Tunis, Tunis, Tunisie
    Proteomics 4:505-13. 2004
    The effect of heat stress on hexaploid wheat grain proteome was recently analyzed in our previous works. Proteomic tools allowed the characterization of heat-responsive proteins of total endosperm, composed mainly of prolamins...
  101. ncbi Birth weight and environmental heat load: a between-population analysis
    Jonathan C K Wells
    MRC Childhood Nutrition Research Centre, Institute of Child Health, London WC1N 1EH, UK
    Am J Phys Anthropol 119:276-82. 2002
    ..and disease load, developing-country and Western populations are also characterized by different environmental heat loads...

Research Grants75

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  3. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..the discovery of the transient receptor potential (Trp) family of liganded ion channels, which include the noxious heat/pepper receptor TrpV1, the mustard oil receptor TrpA1, and the cold/menthol receptor TrpM8...
  4. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..This purely physical technique does not involve the use of heat, chemicals and/or irradiation, each of which has significant drawbacks in the viral inactivation of human plasma...
  5. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ..Moreover, amino acid substitution, mild heat, physiological concentrations of urea (1 mM) all unfold the ferritin pores to increase iron mineral reduction/..
  6. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..Early in the 1900's, Coley successfully used a mix of heat-killed Streptococcus and Serratia bacteria to treat a variety of sarcomas and other cancers...
  7. Role and Regulation of INrf2
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..analysis demonstrated interaction of INrf2 also with Phosphoglyerate mutase family member 5 (PGAM5)/BclXL/Bcl2, heat shock HSP90 and methylosome subunit pICln for unknown functions...
  8. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Alpha B crystallin (Cryab), a member of the small heat shock protein family, recently has been shown to be a broad based anti-inflammatory agent effective in animal models of multiple sclerosis, ..
  9. Genomics of Antiviral Responses of Anopheles gambiae Against O'nyong-nyong Virus
    Young S Hong; Fiscal Year: 2010
    ..gambiae seem to actively modulate ONNV replication through induction of a heat shock cognate protein, hsc-70B. In ONNV- infected An...
  10. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    ..One approach is to up-regulate heat shock protein 70 (HSP70), which binds both Apaf-1 and AIF at distinct sites, thereby neutralizing their pro- ..
  11. Intracellular Phase Diagram Creation Using a Micro-Differential Scanning Calorime
    GARY L SOLBREKKEN; Fiscal Year: 2010
    ..We have experimentally established that the proposed design concept is capable of detecting the latent heat released from a single porcine oocyte with a cell diameter of about 100 [unreadable]m...
  12. Conditional HSF1 Expression for Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2012
    ..upregulation of HSP synthesis requires repression of tight basal repression (control) and full activation of the Heat Shock Factor 1 (HSF1) by a highly conserved process triggered by diverse stimuli under stressful conditions...
  13. Biochemical Characterization of Cytochrome b5 Reductase in Candida albicans
    ..the knockout phenotype of the two cb5r isoforms, CBR1 and MCR1, on cell growth and viability in response to pH, heat shock, and oxidative stress in Candida albicans and the yeast model system, Saccharomyces cerevisiae...
  14. Heat Shock Protein Synthesis Inhibitor Treatment of Hepatitis C Viral Infection
    SAMUEL WHEELER FRENCH; Fiscal Year: 2013
    ..We have identified the heat shock proteins (HSP)s HSP40 and HSP70 in complex with the HCV encoded protein NS5A through mass spectrometric ..
  15. IGFBP-5 and Hsp70 in Extracellular Matrix Homeostasis and Fibrosis
    Kristen L Veraldi; Fiscal Year: 2013
    ..Additionally, there is reduced expression of the Hsp70 heat shock protein both in vivo in lung tissue and primary fibroblasts from patients with SSc-associated pulmonary ..
  16. Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in Hydrogel
    Sihong Wang; Fiscal Year: 2010
    ..In addition, the upregulation of heat shock proteins (HSPs) and their important roles in embryonic development have been widely recognized...
  17. Amelioration of cisplatin ototoxicity by transplatin
    Debashree Mukherjea; Fiscal Year: 2010
    ..of NADPH oxidase subunlts (such as N0X3, Rac1, p22phox and p67phox), stress proteins (such as TRPV1, KIM-1, heat shock proteins and heat shock factor) and apoptotic proteins will also be assessed...
    Sanjay Awasthi; Fiscal Year: 2011
    ..between Rlip and ral, cdc42, clathrin-adapter AP-2, POB1, epsin, grb2/nck, src, insulin, EGF-R, TGF beta, hsf-1 and heat shock proteins...
  19. Mechanisms of Vasovagal Syncope
    Julian M Stewart; Fiscal Year: 2013
    ..Basal and local heat stimulated NO will be assessed...
  20. Prevention of Retinal Degeneration by Crystallins in Experimental Uveitis
    Narsing A Rao; Fiscal Year: 2011
    ..to the photoreceptors and are not mediated by well-recognized anti-apoptotic proteins, including 1B crystallin, heat shock protein 27 and other heat shock proteins...
  21. Anti-inflammatory effects of colitis-induced changes in commensal gut microbes
    JONATHAN JAMES HANSEN; Fiscal Year: 2013
    ..animal models of IBD's suggest that inflammation causes intestinal bacteria to increase expression of small heat shock proteins, which in turn attenuate host inflammation...
  22. Role of Heat Shock Transcription Factor Hsf1 in Tumorigenesis
    Nahid F Mivechi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A hallmark in the pathogenesis of cancer is the increased expression of heat shock proteins (Hsps) and other molecular chaperones...
  23. Climate Change and Adverse Birth Outcomes: Assessing the Vulnerability of Pregnan
    Shao Lin; Fiscal Year: 2013
    ..Moreover, the study will assess whether pregnant women with certain chronic diseases, those taking heat-sensitizing medications, those of low socioeconomic status, those who smoke or drink alcohol, or those with outdoor ..
  24. Novel Chaperone Mechanism for Platelet Disorder
    Zihai Li; Fiscal Year: 2010
    ..Such a process is often catalyzed by molecules referred to as heat-shock proteins (HSPs). We have data to implicate for the first time that loss of one HSP called gp96 can cause BSS...
  25. CSHL 2010 Conference on Molecular Genetics and Bacteria & Phages
    David J Stewart; Fiscal Year: 2010
    ..recombination, repair, transposition, transcription, control of gene expression, translation, signaling, heat shock, protein folding and secretion, stress response, cell development and division, and pathogenesis...
  26. Mapping Orofacial Nociceptive Pathways and Alterations Due to Inflammation
    JOSHUA EMRICK; Fiscal Year: 2013
    ..Inflammation involving the aforementioned sites produces characteristic symptoms: swelling, redness, heat, and pain...
  27. The Impact of Heat Shock Protein Expression on Inflammation and Insulin Action
    Andrea L Hevener; Fiscal Year: 2013
    ..defense against inflammatory insult includes the rapid synthesis of a family of chaperone proteins known as heat shock proteins (HSPs) through the induction of heat shock transcritpion factor (HSF)-1...
  28. Combination Clostridium Difficile Toxin and Adhesin Vaccine
    Ciaran P Kelly; Fiscal Year: 2013
    ..and transcutaneous will be compared to parenteral immunization in the presence of mucosal adjuvants such as heat labile enterotoxin, LT (r192g)...
  29. The Role of FKBP10 in Recessive Osteogenesis Imperfecta
    Caressa Lietman; Fiscal Year: 2013
    ..The FKBP65 protein complexes with Heat Shock Protein 47 (HSP47) and together they are thought to be involved in chaperoning of collagen in the endoplasmic ..
  30. Quantitative Assessment of Oxidative Metabolism in Brown Fat
    Otto Muzik; Fiscal Year: 2011
    ..is a thermogenic organ that plays a critical role in non- shivering thermogenesis with the purpose of generating heat in response to cold stress...
  31. 2012 CSHL Bacteria &Phages Conference
    David J Stewart; Fiscal Year: 2012
    ..recombination, repair, transposition, transcription, control of gene expression, translation, signaling, heat shock, protein folding and secretion, stress response, cell development and division, and pathogenesis...
  32. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..Factors that stimulate primary sensory neurons include hydrogen ions, heat, leukotrienes, arachidonic acid metabolites, bradykinin, and proteases such as trypsin, all of which may ..
  33. Age and Control of Human Skin Flow
    W Larry Kenney; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Humans over the age of 65 contribute disproportionately to cold- and heat-related morbidities and mortalities and the relative risk of death from all causes increases during cold and hot weather...
  34. Targeting Tight Junctions To Treat Mucositis
    FREDERICK GARY TOBACK; Fiscal Year: 2010
    ..increased accumulation of TJ proteins (occludin, ZO-1), and stimulated the phosphorylation of p38 MAP kinase and heat shock protein 25 which could stabilize actin filaments...
  35. Imaging Strategies to Measure Brown Fat and Its Activity
    C Ronald Kahn; Fiscal Year: 2010
    ..occurs in the form of activity and in basal caloric needs for maintenance of cell function and for generating heat, or thermogenesis...
  36. Sympathetic Regulation of AMPK in the control of non-shivering thermogenesis
    Jacob D Mulligan; Fiscal Year: 2012
    ..Our studies examine a way of metabolizing calories into heat instead of storing them as fat, and the possibility that the "health" of fat is regulated by a branch of the ..
    Helene G Margolis; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Background: Virtually all heat-related morbidity/mortality (HRMM) is preventable, yet extreme heat events (EHE) remain the leading cause of weather-related deaths in the United States...
  38. Inner Ear Impact of Chronic Middle Ear Inflammation
    DENNIS ROYAL TRUNE; Fiscal Year: 2013
    ..The proposed studies will utilize BALB/c mice inoculated with heat-killed bacteria (acute otitis media) and C3H/HeJ mice defective for Toll-like receptor 4 (chronic otitis media)...
  39. Combination Clostridium Difficile Toxin and Adhesin Vaccine
    Ciaran P Kelly; Fiscal Year: 2011
    ..and transcutaneous will be compared to parenteral immunization in the presence of mucosal adjuvants such as heat labile enterotoxin, LT(r192g)...
  40. Bacterial Stress Responses to Intestinal Inflammation
    JONATHAN JAMES HANSEN; Fiscal Year: 2013
    ..Intestinal inflammation triggers NC101 to upregulate the bacterial stress-response gene ibpB. IbpB is a small heat shock protein that helps bacteria tolerate heat stress and high levels of reactive oxygen species (ROS) as is found ..
  41. Sex Differences in the Cannabioid Regulation of Energy Homeostasis
    Edward J Wagner; Fiscal Year: 2013
    ..and antagonists to alter food intake, meal pattern, core body temperature, O2 consumption, CO2 and metabolic heat production, 2) endogenous cannabinoid production and subsequent presynaptic inhibition of excitatory glutamatergic ..
  42. Liver Cell Membrane Protein-Expression and Function
    Allan W Wolkoff; Fiscal Year: 2012
    ..its trafficking to and from the plasma membrane;(Project 3) discovery that the association of a potential sorting heat shock protein heterocomplex with the phosphorylated asialoglycoprotein receptor cytoplasmic domain is mediated by a ..
  43. Optimization of HDAC6 Inhibitors in the Treatment of CMT
    Ludo Van Den Bosch; Fiscal Year: 2013
    ..Mutations in the small heat-shock protein 27 (HSPB1) cause axonal CMT or distal hereditary motor neuropathy (distal HMN)...
  44. Immunomodulatory Mechanisms of Withafarin A in Her-2 neu breast cancer
    ANNALISE ROXANNE SMITH; Fiscal Year: 2013
    ..data indicates that WA causes cell death and also induces the expression of immunostimulatory proteins such as heat shock protein 70 (HSP70) in a dose dependent fashion...
  45. Mechanism of PsrP mediated adhesion
    Carlos J Orihuela; Fiscal Year: 2013
    ..We will determine the effects of deleting ciaRH (a two-component system responsive to oxygen), hrcA &ctsrA (heat-shock response regulators), and stkP (global stress regulator) on psrP-secY2A2 expression. Aim 2...
  46. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    Patty J Lee; Fiscal Year: 2012
    ..STAT3 is critical to the protective effects of HO-1 during lethal oxidant injury and that an antioxidant molecule, heat shock protein, Hsp70, is modulated by STAT3...
  47. Heat shock protein 90 antagonist-based therapy of mantle cell lymphoma
    Kapil Bhalla; Fiscal Year: 2012
    ..b>Heat shock protein (hsp) 90 is an ATP-dependent molecular chaperone required for the proper folding and maintenance of ..
  48. Dissecting the Function and Regulation of Stress-Induced SUMOylation
    ..with the SIS response, comparisons of wild type and siz1 mutant plants will be performed before and after heat stress...
    JOHN IRWIN CLARK; Fiscal Year: 2013
    ..to define the functional mechanism for the protective actions of the stress protein, human ?B crystallin, a small heat shock protein (sHSP) and molecular chaperone...
  50. Heat Shock-Induced Apoptosis
    Shawn B Bratton; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hyperthermia or heat shock therapy is currently being utilized in phase II/III clinical trials, either alone or in combination with radiation or chemotherapy, for the treatment of various cancers...
  51. Toll-Like Receptor-Mediated Photoreceptor Mitochondrial DNA Damage
    Narsing A Rao; Fiscal Year: 2010
    ..In this application, TLR4 induced by heat-killed mycobacteria injected at distant sites initiates neuronal cell oxidative stress and mitochondrial DNA damage ..
  52. Regulation of Tumor Associated Macrophages by TGF-beta
    Venkateshwar G Keshamouni; Fiscal Year: 2012
    ..However, The TME is rich in host derived molecules, including heat shock proteins, double stranded DNA from necrotic tumor cells and Hyaluronic acid that can potentially activate ..
  53. Antibody cytokine fusion proteins against Cryptococcus neoformans
    DAVID OWEN BEENHOUWER; Fiscal Year: 2012
    ..To determine the potential of antibody-cytokine fusion proteins to generate protective immunity to C. neoformans. Heat-killed C...
  54. Identification of key tumor cell-released factors that induce cachexia
    Yi Ping Li; Fiscal Year: 2013
    ..In preliminary studies, we found that a number of cachectic tumor cells constitutively release specific heat shock proteins (HSPs), which appear to be critical agents in tumor-induced cachexia...
  55. Microbial regulation of intestinal gene expression through microRNA
    Sushila Dalal; Fiscal Year: 2012
    ..I have chosen to investigate whether miRNAs are involved in the microbial regulation of intestinal heat shock proteins (Hsps)...
  56. Regulation of Intestinal Epithelial Tight Junction Barrier
    Thomas Y Ma; Fiscal Year: 2011
    ..and infectious diarrheal syndromes) and systemic inflammatory conditions (including alcoholic liver disease, heat stroke, hemorrhagic shock, and critically ill)...
  57. Development of Small Heat Shock Proteins as Therapeutic Agents in the Eye
    JONATHAN MARK PETRASH; Fiscal Year: 2010
    ..The small heat shock proteins (sHSP) proteins aA-crystallin and aB-crystallin have excellent potential as therapeutic proteins ..
  58. The Role of Beta-Arrestins 1 and 2 in Rheumatoid Arthritis
    Hongkuan Fan; Fiscal Year: 2010
    ..TLR4 and endogenous TLR4 ligands such as hyaluronan and heat shock protein (HSP)22 are highly expressed in synovial tissue from RA patients compared with healthy donors further ..
  59. Stress Proteins in Brain Cell Injury
    Rona G Giffard; Fiscal Year: 2013
    ..Our prior work on this grant, as well as work from others, has shown that the heat shock protein 70 kDa (HSP70) family of chaperones or stress proteins, even if expressed after ischemia, can protect ..
  60. Gene Regulation by and of LEDGF
    Dhirendra P Singh; Fiscal Year: 2012
    ..Acute or chronic stresses provoke multiple cellular reactions, including activation of the heat shock or stress protein response...
  61. Planning a clinical trial of Flash-heated breast milk to decrease morbidity, impr
    Caroline J Chantry; Fiscal Year: 2010
    ..In the study we are planning, the primary aim will be to determine if infants whose mothers receive counseling on heat- treating expressed breast milk once other foods have been introduced are less likely to become infected with HIV ..
  62. Targeting stress-mediated pathways in the treatment of muscle insulin resistance
    Paige C Geiger; Fiscal Year: 2013
    ..provided by applicant): There is a critical need to understand the fundamental antioxidant properties of heat shock proteins (HSPs) in skeletal muscle and establish novel HSP therapies for preventing insulin resistance...
    Jacob E Friedman; Fiscal Year: 2010
    ..to chronic (2-3 yr) maternal high fat diet show a novel transcriptional regulatory pattern (increased HNF4a, PEPCK, Heat Shock Protein Genes) that underlies two potentially important abnormalities: hepatic steatosis and premature ..
  64. Treating cutaneous leishmaniasis by radio-frequency induced heat (RFH) therapy
    Abhay R Satoskar; Fiscal Year: 2012
    ..Recently, radio-frequency-induced heat (RFH) therapy has been used in the treatment of CL...
    Julian Solway; Fiscal Year: 1992
    Numerous studies have related global respiratory heat and/or water loss to the degree of bronchoconstriction induced in asthmatics by isocapnic hyperpnea of dry air...
  66. Mechanical Stress and the Heat-Treatment of Soft Tissue
    JAY HUMPHREY; Fiscal Year: 2003
    DESCRIPTION (Provided by Applicant): The ever-increasing clinical use of heat to treat disease and injury has been driven primarily by advances in laser, micro-wave, radio-frequency and similar technologies, not a fundamental ..
  67. C/EBP and IL-6 Production in Mucosa and Enterocytes
    Per Olof Hasselgren; Fiscal Year: 2006
    ..with increased production of IL-6 in intestinal mucosa and enterocytes, a response that is augmented by the heat shock response...
  68. Determining vaccine candidacy of LT and STa toxoid fusions against enterotoxigeni
    Weiping Zhang; Fiscal Year: 2010
    ..CFAs mediate bacterial attachment to the host epithelium cells, but it is the enterotoxin, the heat-labile (LT) and heat-stable (STa), that stimulate fluid hyper-secretion and cause diarrhea...
  69. Mechanisms of Cardiac Function and Cerebral Vascular Control during Heat Stress
    Robert Matthew Brothers; Fiscal Year: 2010
    ..to identify mechanisms responsible for attenuated blood pressure control leading to orthostatic intolerance during heat stress...
    BARBARA SNIDER; Fiscal Year: 1999
    ..Such therapies could be of real clinical benefit if they are effective when administered hours after ischemia. The heat stress response is a highly conserved response to stress seen in organisms from bacteria to man...
  71. Reducing Social Disparities of Heatwave Impacts in a Changing Climate
    MARIE SYLVIA O apos NEILL; Fiscal Year: 2010
    ..Abstract: Climate change is projected to increase the frequency and intensity of heatwaves, and heat is already one of the principal weather-related causes of mortality in the U.S...
  72. Heat Shock Proteins, Nitric Oxide and Oxygen Consumption in the Heart
    Govindasamy Ilangovan; Fiscal Year: 2009
    ..While HT induces the heat shock proteins (HSP), which can act as chaperones in preventing myocardial infarction, IPC is known to induce ..
    KEVIN SARGE; Fiscal Year: 1999
    ..As a means to realize these goals, we propose to study the expression of Heat Shock Transcription Factor 2 (HSF2) in spermatogenic cells and its function in regulating hsp gene expression in ..
    Gloria Li; Fiscal Year: 1999
    The long term goal of this research project is to understand the molecular mechanisms of cellular response to heat stress in mammalian cells...
  75. Celestrols for Treatment of Neurodegenerative Diseases
    Richard Silverman; Fiscal Year: 2007
    ..Therefore, we propose that the identification of small molecules that elevate the expression of genes encoding heat shock proteins and molecular chaperones should lead to the development of novel therapies beneficial to the ..