cold

Summary

Summary: An absence of warmth or heat or a temperature notably below an accustomed norm.

Top Publications

  1. ncbi Transcriptional regulatory networks in cellular responses and tolerance to dehydration and cold stresses
    Kazuko Yamaguchi-Shinozaki
    Laboratory of Plant Molecular Physiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
    Annu Rev Plant Biol 57:781-803. 2006
  2. pmc Transcriptome changes for Arabidopsis in response to salt, osmotic, and cold stress
    Joel A Kreps
    Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, California 92121, USA
    Plant Physiol 130:2129-41. 2002
  3. ncbi Regulatory network of gene expression in the drought and cold stress responses
    Kazuo Shinozaki
    Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba 305 0074, Japan
    Curr Opin Plant Biol 6:410-7. 2003
  4. pmc Arabidopsis transcriptome profiling indicates that multiple regulatory pathways are activated during cold acclimation in addition to the CBF cold response pathway
    Sarah Fowler
    Department of Energy Plant Research Laboratory and Department of Crop and Soil Sciences, Michigan State University, East Lansing, MI 48824 1312, USA
    Plant Cell 14:1675-90. 2002
  5. pmc Monitoring expression profiles of rice genes under cold, drought, and high-salinity stresses and abscisic acid application using cDNA microarray and RNA gel-blot analyses
    M Ashiq Rabbani
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant Physiol 133:1755-67. 2003
  6. ncbi OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought-, high-salt- and cold-responsive gene expression
    Joseph G Dubouzet
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant J 33:751-63. 2003
  7. ncbi ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    Gina M Story
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 112:819-29. 2003
  8. ncbi Cold stress regulation of gene expression in plants
    Viswanathan Chinnusamy
    Water Technology Centre, Indian Agricultural Research Institute, New Delhi, India
    Trends Plant Sci 12:444-51. 2007
  9. ncbi DNA-binding specificity of the ERF/AP2 domain of Arabidopsis DREBs, transcription factors involved in dehydration- and cold-inducible gene expression
    Yoh Sakuma
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki, 305 8686, Japan
    Biochem Biophys Res Commun 290:998-1009. 2002
  10. ncbi TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction
    Kelvin Y Kwan
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 50:277-89. 2006

Research Grants

  1. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
  2. SHAOCHUNG VICTOR HSIA; Fiscal Year: 2016
  3. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
  4. Merrill D Benson; Fiscal Year: 2014
  5. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
  6. The Habenulo-Interpeduncular Pathway and Nicotine
    Christie D Fowler; Fiscal Year: 2013
  7. Novel DNA-Launched Attenuated Vaccine for VEE Virus
    PETER M PUSHKO; Fiscal Year: 2012
  8. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
  9. Aquilur Rahman; Fiscal Year: 2014
  10. Danny A Riley; Fiscal Year: 2014

Detail Information

Publications389 found, 100 shown here

  1. ncbi Transcriptional regulatory networks in cellular responses and tolerance to dehydration and cold stresses
    Kazuko Yamaguchi-Shinozaki
    Laboratory of Plant Molecular Physiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
    Annu Rev Plant Biol 57:781-803. 2006
    ..Recent progress has been made in analyzing the complex cascades of gene expression in drought and cold stress responses, especially in identifying specificity and cross talk in stress signaling...
  2. pmc Transcriptome changes for Arabidopsis in response to salt, osmotic, and cold stress
    Joel A Kreps
    Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, California 92121, USA
    Plant Physiol 130:2129-41. 2002
    To identify genes of potential importance to cold, salt, and drought tolerance, global expression profiling was performed on Arabidopsis plants subjected to stress treatments of 4 degrees C, 100 mM NaCl, or 200 mM mannitol, respectively...
  3. ncbi Regulatory network of gene expression in the drought and cold stress responses
    Kazuo Shinozaki
    Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba 305 0074, Japan
    Curr Opin Plant Biol 6:410-7. 2003
    Molecular and genomic studies have shown that several genes with various functions are induced by drought and cold stresses, and that various transcription factors are involved in the regulation of stress-inducible genes...
  4. pmc Arabidopsis transcriptome profiling indicates that multiple regulatory pathways are activated during cold acclimation in addition to the CBF cold response pathway
    Sarah Fowler
    Department of Energy Plant Research Laboratory and Department of Crop and Soil Sciences, Michigan State University, East Lansing, MI 48824 1312, USA
    Plant Cell 14:1675-90. 2002
    ..Arabidopsis, increase in freezing tolerance in response to low, nonfreezing temperatures, a phenomenon known as cold acclimation...
  5. pmc Monitoring expression profiles of rice genes under cold, drought, and high-salinity stresses and abscisic acid application using cDNA microarray and RNA gel-blot analyses
    M Ashiq Rabbani
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant Physiol 133:1755-67. 2003
    To identify cold-, drought-, high-salinity-, and/or abscisic acid (ABA)-inducible genes in rice (Oryza sativa), we prepared a rice cDNA microarray including about 1700 independent cDNAs derived from cDNA libraries prepared from drought-, ..
  6. ncbi OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought-, high-salt- and cold-responsive gene expression
    Joseph G Dubouzet
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant J 33:751-63. 2003
    ..Expression of OsDREB1A and OsDREB1B was induced by cold, whereas expression of OsDREB2A was induced by dehydration and high-salt stresses...
  7. ncbi ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    Gina M Story
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 112:819-29. 2003
    ..Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological ..
  8. ncbi Cold stress regulation of gene expression in plants
    Viswanathan Chinnusamy
    Water Technology Centre, Indian Agricultural Research Institute, New Delhi, India
    Trends Plant Sci 12:444-51. 2007
    b>Cold stress adversely affects plant growth and development. Most temperate plants acquire freezing tolerance by a process called cold acclimation...
  9. ncbi DNA-binding specificity of the ERF/AP2 domain of Arabidopsis DREBs, transcription factors involved in dehydration- and cold-inducible gene expression
    Yoh Sakuma
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki, 305 8686, Japan
    Biochem Biophys Res Commun 290:998-1009. 2002
    ..The DREB subfamily included three novel DREB1A- and six DREB2A-related proteins. We analyzed expression of novel genes for these proteins and discuss their roles in stress-responsive gene expression...
  10. ncbi TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction
    Kelvin Y Kwan
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 50:277-89. 2006
    ..dorsal root ganglion neurons and by cells of the inner ear, where it has proposed roles in sensing sound, painful cold, and irritating chemicals...
  11. ncbi Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    Michael Bandell
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Neuron 41:849-57. 2004
    ..The natural compounds capsaicin and menthol activate noxious heat-sensitive TRPV1 and cold-sensitive TRPM8, respectively...
  12. pmc Arabidopsis Cys2/His2-type zinc-finger proteins function as transcription repressors under drought, cold, and high-salinity stress conditions
    Hideki Sakamoto
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki 305 8686, Japan
    Plant Physiol 136:2734-46. 2004
    ..RNA gel-blot analysis showed that expression of AZF2 and STZ was strongly induced by dehydration, high-salt and cold stresses, and abscisic acid treatment...
  13. ncbi Important roles of drought- and cold-inducible genes for galactinol synthase in stress tolerance in Arabidopsis thaliana
    Teruaki Taji
    Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Plant J 29:417-26. 2002
    ..Here we examine the functions of RFO in Arabidopsis thaliana plants under drought- and cold-stress conditions, based on the analyses of function and expression of genes involved in RFO biosynthesis...
  14. ncbi A TRP channel that senses cold stimuli and menthol
    Andrea M Peier
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Cell 108:705-15. 2002
    ..Cells overexpressing the TRPM8 channel can be activated by cold temperatures and by a cooling agent, menthol...
  15. pmc The Arabidopsis cold-responsive transcriptome and its regulation by ICE1
    Byeong Ha Lee
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Plant Cell 17:3155-75. 2005
    To understand the gene network controlling tolerance to cold stress, we performed an Arabidopsis thaliana genome transcript expression profile using Affymetrix GeneChips that contain approximately 24,000 genes...
  16. ncbi The AtGenExpress global stress expression data set: protocols, evaluation and model data analysis of UV-B light, drought and cold stress responses
    Joachim Kilian
    Zentrum für Molekularbiologie der Pflanzen, Pflanzenphysiologie, Universitat Tubingen, Auf der Morgenstelle 1, 72076 Tubingen, Germany
    Plant J 50:347-63. 2007
    ..of identical genotype grown under identical conditions, to different environmental stresses comprising heat, cold, drought, salt, high osmolarity, UV-B light and wounding...
  17. ncbi Reefs of the deep: the biology and geology of cold-water coral ecosystems
    J Murray Roberts
    Scottish Association for Marine Science, Dunstaffnage Marine Laboratory, Oban, Argyll, PA37 1QA, UK
    Science 312:543-7. 2006
    ..Threats to these fragile, long-lived, and rich ecosystems are mounting: The impacts of deep-water trawling are already widespread, and effects of ocean acidification are potentially devastating...
  18. pmc Heat-related and cold-related deaths in England and Wales: who is at risk?
    S Hajat
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Occup Environ Med 64:93-100. 2007
    Despite the high burden from exposure to both hot and cold weather each year in England and Wales, there has been relatively little investigation on who is most at risk, resulting in uncertainties in informing government interventions.
  19. ncbi Identification of a cold receptor reveals a general role for TRP channels in thermosensation
    David D McKemy
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 0450, USA
    Nature 416:52-8. 2002
    The cellular and molecular mechanisms that enable us to sense cold are not well understood. Insights into this process have come from the use of pharmacological agents, such as menthol, that elicit a cooling sensation...
  20. pmc Arabidopsis CBF1 and CBF3 have a different function than CBF2 in cold acclimation and define different gene classes in the CBF regulon
    Fernando Novillo
    Departamento de Biotecnologia, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria, Carretera de La Coruna, Km 7, 28040 Madrid, Spain
    Proc Natl Acad Sci U S A 104:21002-7. 2007
    ..of Arabidopsis transcriptional activators (CBF1/DREB1B, CBF2/DREB1C, and CBF3/DREB1A) that play a prominent role in cold acclimation...
  21. pmc CBF2/DREB1C is a negative regulator of CBF1/DREB1B and CBF3/DREB1A expression and plays a central role in stress tolerance in Arabidopsis
    Fernando Novillo
    Departamento de Biotecnologia, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria, Carretera de La Coruna, Kilómetro 7, 28040 Madrid, Spain
    Proc Natl Acad Sci U S A 101:3985-90. 2004
    ..of transcriptional activators that have been described as playing an important role in freezing tolerance and cold acclimation in Arabidopsis...
  22. ncbi Recent developments in bacterial cold-shock response
    Sangita Phadtare
    Department of Biochemistry, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
    Curr Issues Mol Biol 6:125-36. 2004
    ..b>Cold-shock response and adaptation has been quite extensively studied in Escherichia coli and Bacillus subtilis...
  23. ncbi Functional analysis of rice DREB1/CBF-type transcription factors involved in cold-responsive gene expression in transgenic rice
    Yusuke Ito
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, Tsukuba, Ibaraki
    Plant Cell Physiol 47:141-53. 2006
    ..The genes for DREB1 orthologs, OsDREB1A and OsDREB1B from rice, are induced by cold stress, and overexpression of DREB1 or OsDREB1 induced strong expression of stress-responsive genes in transgenic ..
  24. ncbi Mass spectrometric approach for identifying putative plasma membrane proteins of Arabidopsis leaves associated with cold acclimation
    Yukio Kawamura
    Cryobiosystem Research Center, Faculty of Agriculture, Iwate University, Morioka 020 8550, Japan
    Plant J 36:141-54. 2003
    Although enhancement of freezing tolerance in plants during cold acclimation is closely associated with an increase in the cryostability of plasma membrane, the molecular mechanism for the increased cryostability of plasma membrane is ..
  25. pmc Cold periods and coronary events: an analysis of populations worldwide
    Adrian G Barnett
    School of Population Health, University of Queensland, Herston, QLD 4006, Australia
    J Epidemiol Community Health 59:551-7. 2005
    To investigate the association between cold periods and coronary events, and the extent to which climate, sex, age, and previous cardiac history increase risk during cold weather.
  26. pmc The negative regulator of plant cold responses, HOS1, is a RING E3 ligase that mediates the ubiquitination and degradation of ICE1
    Chun Hai Dong
    Institute for Integrative Genome Biology and Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 103:8281-6. 2006
    Plant responses to cold stress are mediated by a transcriptional cascade, in which the transcription factor ICE1 and possibly related proteins activate the expression of C-repeat (CRT)-binding factors (CBFs), leading to the transcription ..
  27. pmc A DEAD box RNA helicase is essential for mRNA export and important for development and stress responses in Arabidopsis
    Zhizhong Gong
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China
    Plant Cell 17:256-67. 2005
    An Arabidopsis thaliana mutant, cryophyte, was isolated and found to have an enhanced cold stress-induction of the master regulator of cold tolerance, C-repeat binding factor 2 (CBF2), and its downstream target genes...
  28. pmc A global survey of gene regulation during cold acclimation in Arabidopsis thaliana
    Matthew A Hannah
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Potsdam, Germany
    PLoS Genet 1:e26. 2005
    ..are able to increase their freezing tolerance when exposed to low, nonfreezing temperatures in a process called cold acclimation. This process is accompanied by complex changes in gene expression...
  29. ncbi Guidelines for the cold pressor task as an experimental pain stimulus for use with children
    Carl L von Baeyer
    Department of Psychology, University of Saskatchewan, Saskatoon, Canada
    J Pain 6:218-27. 2005
    The cold pressor task (CPT) involves placing a hand or forearm in cold water, a stimulus that produces a slowly mounting pain of mild to moderate intensity and is terminated by voluntary withdrawal of the limb...
  30. ncbi Over-expression of calcium-dependent protein kinase 13 and calreticulin interacting protein 1 confers cold tolerance on rice plants
    Setsuko Komatsu
    National Institute of Crop Science, 2 1 18 Kannondai, Tsukuba 305 8518, Japan
    Mol Genet Genomics 277:713-23. 2007
    ..13 (CDPK13) and calreticulin interacting protein 1 (CRTintP1) have previously been reported to be involved in cold stress response in rice...
  31. ncbi Involvement of the mitochondrial pathway in cold storage and rewarming-associated apoptosis of human renal proximal tubular cells
    Abdulla K Salahudeen
    Departments of Medicine and Anatomy, University of Mississippi Medical Center, Jackson, MS, USA
    Am J Transplant 3:273-80. 2003
    The cellular and molecular mechanisms of cold storage-ATN are not well characterized. In our earlier studies, cold storage caused necrosis of human proximal tubular epithelial (RPTE) cells, whereas apoptosis was prominent during rewarming...
  32. ncbi Genome-wide transcriptional profiling of the Bacillus subtilis cold-shock response
    Tanja Kaan
    Institut fur Mikrobiologie, Ernst Moritz Arndt Universitat Greifswald, F L Jahn Str 15, D 17487 Greifswald, Germany
    Microbiology 148:3441-55. 2002
    ..of around 50 genes exhibiting an increased mRNA level and around 50 genes exhibiting a decreased mRNA level under cold-shock conditions...
  33. ncbi Cloning and functional analysis of a novel DREB1/CBF transcription factor involved in cold-responsive gene expression in Zea mays L
    Feng Qin
    Department of Biological Sciences and Biotechnology, Tsinghua University, 100084 Beijing, China
    Plant Cell Physiol 45:1042-52. 2004
    ..Expression of ZmDREB1A was induced by cold stress and slightly increased by high-salinity stress...
  34. pmc Cold adaptation in budding yeast
    Babette Schade
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada H4P 2R2
    Mol Biol Cell 15:5492-502. 2004
    We have determined the transcriptional response of the budding yeast Saccharomyces cerevisiae to cold. Yeast cells were exposed to 10 degrees C for different lengths of time, and DNA microarrays were used to characterize the changes in ..
  35. ncbi Physical and functional interactions among RNase E, polynucleotide phosphorylase and the cold-shock protein, CsdA: evidence for a 'cold shock degradosome'
    Annie Prud'homme-Généreux
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    Mol Microbiol 54:1409-21. 2004
    ..Here we demonstrate that one member of this family, CsdA, whose expression is induced by cold shock, interacts physically and functionally with RNase E...
  36. ncbi TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
    Diana M Bautista
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 124:1269-82. 2006
    ..TRPA1 has been proposed to function in diverse sensory processes, including thermal (cold) nociception, hearing, and inflammatory pain...
  37. pmc LOS2, a genetic locus required for cold-responsive gene transcription encodes a bi-functional enolase
    Hojoung Lee
    Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    EMBO J 21:2692-702. 2002
    The Arabidopsis mutation, los2, impairs cold-responsive gene transcription, acquired freezing tolerance and plant resistance to chilling under certain conditions...
  38. pmc CBL1, a calcium sensor that differentially regulates salt, drought, and cold responses in Arabidopsis
    Yong Hwa Cheong
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Plant Cell 15:1833-45. 2003
    ..Although drought-induced gene expression was enhanced, gene induction by cold was inhibited...
  39. ncbi Proteomic analysis of rice seedlings during cold stress
    Makoto Hashimoto
    National Institute of Agrobiological Sciences, Tsukuba, Japan
    Proteomics 7:1293-302. 2007
    ..To investigate the responses of rice to cold stress, changes in protein expression were analyzed using a proteomic approach...
  40. ncbi Metabolomic profiling of rapid cold hardening and cold shock in Drosophila melanogaster
    Johannes Overgaard
    National Environmental Research Institute, University of Aarhus, Department of Terrestrial Ecology, Vejlsøvej 25, DK 8600 Silkeborg, Denmark
    J Insect Physiol 53:1218-32. 2007
    A short exposure to a mild cold stress is sufficient to increase cold tolerance in many insects. This phenomenon, termed rapid cold hardening (RCH) expands the thermal interval that can be exploited by the insect...
  41. pmc Diversity and distribution of methanotrophic archaea at cold seeps
    Katrin Knittel
    Max Planck Institute for Marine Microbiology, Department of Molecular Ecology, Celsiusstrasse 1, 28359 Bremen, Germany
    Appl Environ Microbiol 71:467-79. 2005
    ..of the samples by fluorescence in situ hybridization (FISH) showed that ANME-1 and ANME-2 co-occurred at the cold seep sites investigated...
  42. ncbi Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure
    Georgina Cano
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Comp Neurol 460:303-26. 2003
    The thermogenic activity of interscapular brown adipose tissue (IBAT) in response to physiologic stimuli, such as cold exposure, is controlled by its sympathetic innervation...
  43. ncbi Molecular adaptations to cold in psychrophilic enzymes
    G Feller
    Laboratory of Biochemistry, Institute of Chemistry B6, University of Liege, 4000 Liege, Belgium
    Cell Mol Life Sci 60:648-62. 2003
    Psychrophiles or cold-loving organisms successfully colonize cold environments of the Earth's biosphere...
  44. ncbi Human physiological responses to cold exposure
    Jodie M Stocks
    Department of Biomedical Science, University of Wollongong, Wollongong, N S W, Australia
    Aviat Space Environ Med 75:444-57. 2004
    Thermal energy is transferred within and between bodies via several avenues, but for most unprotected human cold exposures, particularly during immersion, convective heat loss dominates...
  45. ncbi Freezing-sensitive tomato has a functional CBF cold response pathway, but a CBF regulon that differs from that of freezing-tolerant Arabidopsis
    Xin Zhang
    MSU DOE Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Plant J 39:905-19. 2004
    Many plants increase in freezing tolerance in response to low temperature, a process known as cold acclimation. In Arabidopsis, cold acclimation involves action of the CBF cold response pathway...
  46. pmc Coping with cold: An integrative, multitissue analysis of the transcriptome of a poikilothermic vertebrate
    Andrew Y Gracey
    School of Biological Sciences, University of Liverpool, Biosciences Building, Crown Street, Liverpool L39 7ZB, United Kindgom
    Proc Natl Acad Sci U S A 101:16970-5. 2004
    ..Carp were exposed to increasing levels of cold, and responses across seven tissues were assessed by using a microarray composed of 13,440 cDNA probes...
  47. pmc Low temperature induction of Arabidopsis CBF1, 2, and 3 is gated by the circadian clock
    Sarah G Fowler
    Michigan State University U S Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Physiol 137:961-8. 2005
    ..The highest and lowest levels of cold-induced CBF1-3 transcript accumulation occurred at 4 and 16 h after subjective dawn, respectively...
  48. ncbi LIP19, a basic region leucine zipper protein, is a Fos-like molecular switch in the cold signaling of rice plants
    Hidekazu Shimizu
    Graduate School of Life Sciences, Tohoku University, Aoba ku, Sendai, Miyagi, Japan
    Plant Cell Physiol 46:1623-34. 2005
    ..Based upon the presented data, we propose a model describing the low-temperature signal switching mediated by LIP19 in rice...
  49. pmc TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
    Koichi Obata
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    J Clin Invest 115:2393-401. 2005
    b>Cold hyperalgesia is a well-documented symptom of inflammatory and neuropathic pain; however, the underlying mechanisms of this enhanced sensitivity to cold are poorly understood...
  50. ncbi A plant for all seasons: alterations in photosynthetic carbon metabolism during cold acclimation in Arabidopsis
    Mark Stitt
    Max Planck Institute for Molecular Plant Physiology, 1, 14476 Golm, Am Muhlenberg, Germany
    Curr Opin Plant Biol 5:199-206. 2002
    ..Recent progress has been made in understanding both the signals that trigger these processes and how the regulation of photosynthetic carbon metabolism interacts with other processes during cold acclimation.
  51. pmc CIPK3, a calcium sensor-associated protein kinase that regulates abscisic acid and cold signal transduction in Arabidopsis
    Kyung Nam Kim
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Plant Cell 15:411-23. 2003
    ..The expression of the CIPK3 gene itself is responsive to ABA and stress conditions, including cold, high salt, wounding, and drought...
  52. ncbi QTLs conferring cold tolerance at the booting stage of rice using recombinant inbred lines from a japonica x indica cross
    V C Andaya
    Department of Agronomy and Range Science, University of California, Davis, One Shields Avenue, 95616, USA
    Theor Appl Genet 106:1084-90. 2003
    ..japonica, M-202, and a tropical indica, IR50, in order to locate quantitative trait loci (QTLs) conferring cold tolerance. The map with a total length of 1,276.8 cM and an average density of one marker every 7...
  53. ncbi AtDGK2, a novel diacylglycerol kinase from Arabidopsis thaliana, phosphorylates 1-stearoyl-2-arachidonoyl-sn-glycerol and 1,2-dioleoyl-sn-glycerol and exhibits cold-inducible gene expression
    Fernando C Gómez-Merino
    University of Potsdam, Institute of Biochemistry and Biology, Karl Liebknecht Strasse 24 25, Haus 20, D 14476 Golm Potsdam, Germany
    J Biol Chem 279:8230-41. 2004
    ..We found that AtDGK2 is induced by exposure to low temperature (4 degrees C), pointing to a role in cold signal transduction.
  54. ncbi Identification of cold-inducible downstream genes of the Arabidopsis DREB1A/CBF3 transcriptional factor using two microarray systems
    Kyonoshin Maruyama
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant J 38:982-93. 2004
    ..classified into direct downstream genes of DREB1A and the others based on their expression patterns in response to cold stress...
  55. ncbi The effect of cold-induced increased metabolic rate on the rate of 13C and 15N incorporation in house sparrows (Passer domesticus)
    S A Carleton
    Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82072 3166, USA
    Oecologia 144:226-32. 2005
    ..We hypothesized that (1) chronic exposure to cold, and hence an increase in metabolic rate, would increase the rate of isotopic incorporation of both 13C and 15N ..
  56. ncbi Opposite changes in membrane fluidity mimic cold and heat stress activation of distinct plant MAP kinase pathways
    Veena Sangwan
    Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montreal, Quebec, H3A 1B1, Canada
    Plant J 31:629-38. 2002
    ..In plants, no heat shock-activated MAPK has so far been reported. Also, whereas cold activates specific plant MAPKs such as alfalfa SAMK, mechanisms of such activation are unknown...
  57. ncbi Differential gene expression in the brain of channel catfish ( Ictalurus punctatus) in response to cold acclimation
    Z Ju
    Fish Molecular Genetics and Biotechnology Laboratory, Department of Fisheries and Allied Aquacultures and Program of Cell and Molecular Biosciences, 203 Swingle Hall, Auburn University, Auburn, AL 36849, USA
    Mol Genet Genomics 268:87-95. 2002
    ..rapid induction of proteins involved in signal transductions and chaperones suggests that both de novo synthesis of cold-induced proteins and modification of existing proteins are required for adaptation and tolerance of catfish to low ..
  58. ncbi Cold--an underrated risk factor for health
    James B Mercer
    Department of Medical Physiology, Faculty of Medicine, University of Tromsø, N 9037 Tromsø, Norway
    Environ Res 92:8-13. 2003
    ..While much of the indirect evidence points to the notion that cold is somehow involved in explaining excess winter deaths, the mechanism by which seemingly mild exposure to cold ..
  59. pmc The lagged effect of cold temperature and wind chill on cardiorespiratory mortality in Scotland
    M Carder
    Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK
    Occup Environ Med 62:702-10. 2005
    To investigate the lagged effects of cold temperature on cardiorespiratory mortality and to determine whether "wind chill" is a better predictor of these effects than "dry bulb" temperature.
  60. ncbi Cold and light control seed germination through the bHLH transcription factor SPATULA
    Steven Penfield
    Center for Novel Agricultural Products, Department of Biology, University of York, P O Box 373, York, YO10 5YW, United Kingdom
    Curr Biol 15:1998-2006. 2005
    ..on the regulation of the gibberellin (GA) biosynthetic genes GA3 oxidase (GA3ox), whose expression is transcriptionally induced by light and cold in imbibed seeds. However, the molecular basis of this response has until now been unknown.
  61. pmc A putative Arabidopsis nucleoporin, AtNUP160, is critical for RNA export and required for plant tolerance to cold stress
    Chun Hai Dong
    Institute for Integrative Genome Biology and Department of Botany and Plant Science, University of California, Riverside, CA 92521, USA
    Mol Cell Biol 26:9533-43. 2006
    To study the genetic control of plant responses to cold stress, Arabidopsis thaliana mutants were isolated by a screen for mutations that impair cold-induced transcription of the CBF3-LUC reporter gene...
  62. pmc The cold-regulated transcriptional activator Cbf3 is linked to the frost-tolerance locus Fr-A2 on wheat chromosome 5A
    A Vágújfalvi
    Department of Agronomy and Range Science, University of California, One Shields Avenue, Davis, CA 95616 8515, USA
    Mol Genet Genomics 269:60-7. 2003
    Wheat chromosome 5A plays a key role in cold acclimation and frost tolerance...
  63. ncbi The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
    Thomas Voets
    Laboratory of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 430:748-54. 2004
    The mammalian sensory system is capable of discriminating thermal stimuli ranging from noxious cold to noxious heat...
  64. ncbi A proteomic analysis of cold stress responses in rice seedlings
    Suxia Cui
    Laboratory of Molecular Biology and MOE Laboratory of Protein Science, Department of Biological Sciences and Biotechnology, Tsinghua University, BeiJing 100 084, P R China
    Proteomics 5:3162-72. 2005
    Using proteomic analysis, an investigation aimed at a better understanding of the molecular adaptation mechanisms of cold stress was carried out in rice (Oryza sativa)...
  65. ncbi Shifts in the carbohydrate, polyol, and amino acid pools during rapid cold-hardening and diapause-associated cold-hardening in flesh flies (Sarcophaga crassipalpis): a metabolomic comparison
    M Robert Michaud
    Department of Entomology, Ohio State University, 318 W 12th Avenue, Columbus, OH 43210 1242, USA
    J Comp Physiol B 177:753-63. 2007
    Flesh flies can enhance their cold hardiness by entering a photoperiod-induced pupal diapause or by a temperature-induced rapid cold-hardening process...
  66. doi Visualizing cold spots: TRPM8-expressing sensory neurons and their projections
    Ajay Dhaka
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 28:566-75. 2008
    ..Virtually all EGFPf-positive cultured DRG neurons from hemizygous mice (TRPM8(EGFPf/+)) responded to cold and menthol...
  67. pmc A mitochondrial complex I defect impairs cold-regulated nuclear gene expression
    Byeong Ha Lee
    Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    Plant Cell 14:1235-51. 2002
    To study low-temperature signaling in plants, we previously screened for cold stress response mutants using bioluminescent Arabidopsis plants that express the firefly luciferase reporter gene driven by the stress-responsive RD29A promoter...
  68. ncbi Crystal structures of a psychrophilic metalloprotease reveal new insights into catalysis by cold-adapted proteases
    Nushin Aghajari
    Institut de Biologie et Chimie des Proteines, UMR 5086, Laboratoire de Bio Cristallographie, CNRS et Université Claude Bernard Lyon I, Lyon, France
    Proteins 50:636-47. 2003
    ..Finally, the active site is more accessible due to deletions occurring in surrounding loop regions...
  69. ncbi Psychrophilic enzymes: hot topics in cold adaptation
    Georges Feller
    Laboratory of Biochemistry, Institute of Chemistry B6, University of Liege, B 4000 Liege Sart Tilman, Belgium
    Nat Rev Microbiol 1:200-8. 2003
    More than three-quarters of the Earth's surface is occupied by cold ecosystems, including the ocean depths, and polar and alpine regions...
  70. ncbi Temperature and the cold pressor test
    Laura A Mitchell
    Department of Psychology, Glasgow Caledonian University, United Kingdom
    J Pain 5:233-7. 2004
    As a method of experimental pain induction, the cold pressor test is thought to mimic the effects of chronic conditions effectively...
  71. ncbi The cold-shock response in cultured mammalian cells: harnessing the response for the improvement of recombinant protein production
    Mohamed B Al-Fageeh
    Protein Science Group, Research School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Biotechnol Bioeng 93:829-35. 2006
    ..Opportunities currently exist for further enhancement of the cold-shock effect on recombinant protein production in mammalian cells through advancements in our understanding of the ..
  72. ncbi Cold-adapted enzymes
    Khawar Sohail Siddiqui
    School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW 2052, Australia
    Annu Rev Biochem 75:403-33. 2006
    By far the largest proportion of the Earth's biosphere is comprised of organisms that thrive in cold environments (psychrophiles). Their ability to proliferate in the cold is predicated on a capacity to synthesize cold-adapted enzymes...
  73. ncbi ABA regulates apoplastic sugar transport and is a potential signal for cold-induced pollen sterility in rice
    Sandra N Oliver
    CSIRO Plant Industry, Canberra, ACT, Australia
    Plant Cell Physiol 48:1319-30. 2007
    b>Cold temperatures cause pollen sterility and large reductions in grain yield in temperate rice growing regions of the world...
  74. ncbi Cloning and characterization of the hsp70 multigene family from silver sea bream: Modulated gene expression between warm and cold temperature acclimation
    Eddie E Deane
    Department of Biology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Biochem Biophys Res Commun 330:776-83. 2005
    ..7-fold whereas the transcript abundance of hsp70 increased 6.7-fold. The chronic acclimation of sea bream to cold temperature (12 degrees C) resulted in a downregulation of hsc70 and an upregulation of hsp70 in comparison to ..
  75. ncbi Comparative analysis of expressed sequence tags from cold-acclimated and non-acclimated leaves of Rhododendron catawbiense Michx
    Hui Wei
    Department of Horticulture, Iowa State University, Ames, IA 50011, USA
    Planta 221:406-16. 2005
    An expressed sequence tag (EST) analysis approach was undertaken to identify major genes involved in cold acclimation of Rhododendron, a broad-leaf, woody evergreen species...
  76. pmc The cold-induced early activation of phospholipase C and D pathways determines the response of two distinct clusters of genes in Arabidopsis cell suspensions
    Chantal Vergnolle
    Laboratoire de Physiologie Cellulaire et Moleculaire des Plantes, Formation de Recherche en Evolution 2846, Centre National de la Recherche Scientifique Université Pierre et Marie Curie, F 94200 Ivry sur Seine, France
    Plant Physiol 139:1217-33. 2005
    ..Therefore, the cold signal has to be perceived and transmitted to the nucleus...
  77. pmc Activation of zoosporogenesis-specific genes in Phytophthora infestans involves a 7-nucleotide promoter motif and cold-induced membrane rigidity
    Shuji Tani
    Department of Plant Pathology, University of California, Riverside, CA 92521, USA
    Eukaryot Cell 5:745-52. 2006
    ..of plants by the oomycete Phytophthora infestans typically result from zoospores, which develop from sporangia at cold temperatures...
  78. ncbi Sterilization of bacteria, yeast, and bacterial endospores by atmospheric-pressure cold plasma using helium and oxygen
    Kyenam Lee
    Department of Biology, College of Natural Sciences, Seoul Women s University, Seoul 139 774, Republic of Korea
    J Microbiol 44:269-75. 2006
    Atmospheric-pressure cold plasma (APCP) using helium/oxygen was developed and tested as a suitable sterilization method in a clinical environment...
  79. ncbi Why get big in the cold? Towards a solution to a life-history puzzle
    Isabell Karl
    Department of Animal Ecology I, Bayreuth University, P O Box 101 251, 95440 Bayreuth, Germany
    Oecologia 155:215-25. 2008
    ..The latter was itself related to a higher daily food consumption, while the total food consumption (due to the females' longer developmental period) and assimilation was higher in females and may underly the sexual body size dimorphism...
  80. ncbi Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure
    Yoshiyuki Kasahara
    Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan
    Biosci Biotechnol Biochem 71:3122-6. 2007
    ..and found that Oxt(-/-) mice exhibited lower body temperatures than wild-type animals when they were exposed to cold. Oxt(-/-) mice also showed slightly more weight gain, but there were no obvious differences in the morphology of ..
  81. ncbi Physical mapping and putative candidate gene identification of a quantitative trait locus Ctb1 for cold tolerance at the booting stage of rice
    K Saito
    National Agricultural Research Center for Hokkaido Region, Hitsujigaoka 1, Toyohira, Sapporo, Hokkaido, Japan
    Theor Appl Genet 109:515-22. 2004
    Norin-PL8 is a cold-tolerant variety of rice (Oryza sativa L.) that was developed by introgressing chromosomal segments from a cold-tolerant tropical japonica variety, Silewah, into a template japonica variety, Hokkai241...
  82. ncbi Effects of Corydalis yanhusuo and Angelicae dahuricae on cold pressor-induced pain in humans: a controlled trial
    Chun Su Yuan
    Tang Center for Herbal Medicine Research, Committee on Clinical Pharmacology, and Department of Anesthesia and Critical Care, Pritzker School of Medicine, University of Chicago, Illinois 60637, USA
    J Clin Pharmacol 44:1323-7. 2004
    ..They used the cold-pressor test-a simple, reliable, and widely used model in humans-for induction of tonic pain...
  83. pmc Characterization of an unusual cold-active beta-glucosidase belonging to family 3 of the glycoside hydrolases from the psychrophilic isolate Paenibacillus sp. strain C7
    Stephanie Shipkowski
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 211 South Frear, University Park, PA 16802, USA
    Appl Environ Microbiol 71:4225-32. 2005
    ..hydrolyzed X-Gal (5-bromo-4-chloro-3-indoyl-beta-D-galactopyranoside) only below 30 degrees C, an indication of cold-active beta-galactosidase activity...
  84. ncbi Fine mapping of the qCTS12 locus, a major QTL for seedling cold tolerance in rice
    V C Andaya
    Crops Pathology and Genetics Research Unit, Department of Plant Sciences, USDA ARS, Davis, CA 95616, USA
    Theor Appl Genet 113:467-75. 2006
    ..line mapping population derived from a cross between M202 and IR50, an indica cultivar that is highly sensitive to cold stress, resulted in the identification of a number of QTL conferring tolerance to cold-induced wilting and necrosis...
  85. ncbi Hormetic effects of repeated exposures to cold at young age on longevity, aging and resistance to heat or cold shocks in Drosophila melanogaster
    Eric Le Bourg
    Centre de Recherche sur la Cognition Animale, UMR CNRS 5169, Universite Paul Sabatier, 118 route de Narbonne, 31062, Toulouse Cedex 9, France
    Biogerontology 8:431-44. 2007
    ..The present experiments tested whether cold shocks at young age could also have hormetic effects...
  86. ncbi A quantitative trait locus for cold tolerance at the booting stage on rice chromosome 8
    Makoto Kuroki
    National Agricultural Research Center for Hokkaido Region, National Agriculture and Food Research Organization NARO, 1 Hitsujigaoka, Toyohira, Sapporo, Hokkaido 062 8555, Japan
    Theor Appl Genet 115:593-600. 2007
    A quantitative trait locus (QTL) for cold tolerance at the booting stage of a cold-tolerant rice breeding line, Hokkai-PL9, was analyzed...
  87. ncbi A genetic link between cold responses and flowering time through FVE in Arabidopsis thaliana
    Hyoun Joung Kim
    Kumho Life and Environmental Science Laboratory, 1 Oryong dong, Puk Gu, Gwangju 500 712, Korea
    Nat Genet 36:167-71. 2004
    b>Cold induces expression of a number of genes that encode proteins that enhance tolerance to freezing temperatures in plants...
  88. pmc Transcriptome analysis of cold acclimation in barley albina and xantha mutants
    Jan T Svensson
    Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Plant Physiol 141:257-70. 2006
    ..chloroplast development are completely frost susceptible as well as impaired in the expression of several cold-regulated genes...
  89. pmc Cold shock domain proteins and glycine-rich RNA-binding proteins from Arabidopsis thaliana can promote the cold adaptation process in Escherichia coli
    Jin Sun Kim
    Department of Plant Biotechnology, Agricultural Plant Stress Research Center and Biotechnology Research Institute, College of Agriculture and Life Sciences, Chonnam National University, Gwangju, 500 757, Republic of Korea
    Nucleic Acids Res 35:506-16. 2007
    Despite the fact that cold shock domain proteins (CSDPs) and glycine-rich RNA-binding proteins (GRPs) have been implicated to play a role during the cold adaptation process, their importance and function in eukaryotes, including plants, ..
  90. pmc Transcriptional profiling of chickpea genes differentially regulated in response to high-salinity, cold and drought
    Nitin L Mantri
    RMIT University, School of Applied Sciences, Biotechnology and Environmental Biology, Building 223, Level 1, Plenty Road, Bundoora, Victoria 3083, Australia
    BMC Genomics 8:303. 2007
    ..chickpea and its close relative Lathyrus sativus, were altered in chickpea by the three abiotic stresses; drought, cold and high-salinity...
  91. ncbi Advantages of normothermic perfusion over cold storage in liver preservation
    Charles J Imber
    Nuffield Department of Surgery, Oxford University, Oxford, United Kingdom
    Transplantation 73:701-9. 2002
    ..In this study, we directly compared preservation by the standard method of simple cold storage in University of Wisconsin (UW) solution with preservation by perfusion.
  92. pmc HOS10 encodes an R2R3-type MYB transcription factor essential for cold acclimation in plants
    Jianhua Zhu
    Department of Horticulture, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 102:9966-71. 2005
    ..The hos10-1 plants are extremely sensitive to freezing temperatures, completely unable to acclimate to the cold, and are hypersensitive to NaCl...
  93. ncbi Diversity, relative abundance and metabolic potential of bacterial endosymbionts in three Bathymodiolus mussel species from cold seeps in the Gulf of Mexico
    Sébastien Duperron
    Max Planck Institute for Marine Microbiology, Bremen, Germany
    Environ Microbiol 9:1423-38. 2007
    b>Cold seeps in the Gulf of Mexico are often dominated by mussels of the genus Bathymodiolus that harbour symbiotic bacteria in their gills...
  94. ncbi Cold-induced recruitment of brown adipose tissue thermogenesis
    Martin Klingenspor
    Animal Physiology, Department of Biology, Philipps University, Marburg, Germany
    Exp Physiol 88:141-8. 2003
    ..During cold acclimation the sympathetic innervation triggers the recruitment of brown adipose tissue by hyperplasia, which ..
  95. ncbi ERF protein JERF1 that transcriptionally modulates the expression of abscisic acid biosynthesis-related gene enhances the tolerance under salinity and cold in tobacco
    Lijun Wu
    National Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, China
    Planta 226:815-25. 2007
    ....
  96. ncbi TRPM8 is required for cold sensation in mice
    Ajay Dhaka
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuron 54:371-8. 2007
    ..We show that mice lacking TRPM8 have severe behavioral deficits in response to cold stimuli...
  97. ncbi Specificity of cold thermotransduction is determined by differential ionic channel expression
    Felix Viana
    Instituto de Neurociencias, Universidad Miguel Hernandez CSIC, Apartado 18, San Juan de Alicante 03550, Spain
    Nat Neurosci 5:254-60. 2002
    Sensations of cold are mediated by specific thermoreceptor nerve endings excited by low temperature and menthol...
  98. ncbi Quantitative and qualitative perceptual analysis of cold dysesthesia and hyperalgesia in fibromyalgia
    Birgitta Berglund
    Institute of Environmental Medicine, Karolinska Institutet and Department of Psychology, Stockholm University, Stockholm, Sweden
    Pain 96:177-87. 2002
    ..Perception thresholds for cold pain, heat pain, cold-pain tolerance and heat-pain tolerance were significantly lower in patients than controls...
  99. pmc An explicit test of the phospholipid saturation hypothesis of acquired cold tolerance in Caenorhabditis elegans
    Patricia Murray
    School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Proc Natl Acad Sci U S A 104:5489-94. 2007
    Protection of poikilothermic animals from seasonal cold is widely regarded as being causally linked to changes in the unsaturation of membrane phospholipids, yet in animals this proposition remains formally untested...
  100. ncbi Temperature adaptation of proteins: engineering mesophilic-like activity and stability in a cold-adapted alpha-amylase
    Salvino D'Amico
    Laboratory of Biochemistry, Institute of Chemistry B6, University of Liege, B 4000, Liege Sart Tilman, Belgium
    J Mol Biol 332:981-8. 2003
    ..This study confirms the central role of weak interactions in regulating the balance between stability and activity of an enzyme in order to adapt to the environmental temperature...
  101. ncbi Some like it cold: biocatalysis at low temperatures
    D Georlette
    Laboratory of Biochemistry, Institute of Chemistry B6, University of Liege, Liège B 4000, Belgium
    FEMS Microbiol Rev 28:25-42. 2004
    ..These organisms, hosts of permanently cold habitats, often display metabolic fluxes more or less comparable to those exhibited by mesophilic organisms at ..

Research Grants84

  1. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..mechanism for recognizing and avoiding harmful stimuli in the environment, including potentially damaging hot and cold temperatures, noxious chemicals such as acids, and sharp touch...
  2. SHAOCHUNG VICTOR HSIA; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): HSV-1 is one of the most common viral infections affecting humans from mild cold sores to severe ocular keratitis and deadly encephalitis...
  3. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..functional brown adipocytes in white fat depots of mice to raise energy expenditure and protect against obesity and cold exposure. Diet-Induced Obesity (DIP)...
  4. Merrill D Benson; Fiscal Year: 2014
    ..syndromes including TNF-alpha receptor associated periodic syndrome (TRAPS), Muckle-Wells syndrome, familial cold urticaria (FCAS), and hyper- immunoglobulin D syndrome...
  5. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..After flushing with cold Perfadex", spiked with R-503 (30 [unreadable]M) or vehicle, donor lungs are stored cold for 12 h before left LTX...
  6. The Habenulo-Interpeduncular Pathway and Nicotine
    Christie D Fowler; Fiscal Year: 2013
    ..First, the PI will obtain didactic instruction by attending a relevant course at either Cold Springs Harbor or Woods Hole and will conduct intensive reading of the literature to be discussed with the mentor ..
  7. Novel DNA-Launched Attenuated Vaccine for VEE Virus
    PETER M PUSHKO; Fiscal Year: 2012
    ..of DNA vaccines (genetic homogeneity and stability, low cost of manufacturing, storage, and transportation, no cold chain) and, more importantly, enhances immunogenicity...
  8. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..SD donor rats are treated with R-801 or vehicle control 10 min before lung removal. After flushing with cold Perfadex" spiked with R-801 or vehicle, donor lungs are stored cold for 12h before left LTX...
  9. Aquilur Rahman; Fiscal Year: 2014
    ..HSV-1 infects between 20-40% of the adult population age 12 and over, and is manifested by recurrent facial cold sores that are treated predominantly with OTC remedies with limited efficacy...
  10. Danny A Riley; Fiscal Year: 2014
    ..loss of feeling and muscle weakness (nerve conduction velocity, von Frey touch perception, thermal sensitivity, and cold immersion provocation rewarming and return of blood flow)...
  11. Targeting thermoreceptors for therapeutic hypothermia
    Sean P Marrelli; Fiscal Year: 2012
    ..Current TH protocols involve actively cooling patients by a variety of methods including cold blankets and ice baths which is slow, uncomfortable, and triggers a shiver response...
  12. Mechanisms of Early Growth Response Factor 1 (Egr-1) Induction by HSV-1 Lytic Inf
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2010
    ..provided by applicant): Herpes simplex virus type-1 (HSV-1) lytic infection causes diseases ranging from simple cold sores to dangerous keratitis and lethal encephalitis...
  13. Protein composition and interactions of telemeric chromatin
    Michael P Killoran; Fiscal Year: 2010
    ..I will also be attending conferences outside the Salk, such as the 2009 Cold Spring Harbor Laboratory Telomeres and Telomerase meeting...
  14. James E Gern; Fiscal Year: 2016
    ..RELEVANCE: Rhinoviruses, originally known as "common cold viruses", also cause lower respiratory illnesses such as childhood wheezing, influenza-like illness, and ..
  15. Transplantation of Reduced-Size Fatty Livers
    Zhi Zhong; Fiscal Year: 2010
    ..assess survival, liver function, and histology after transplantation as a function of steatosis, graft volume and cold storage time...
  16. Climate Change and Adverse Birth Outcomes: Assessing the Vulnerability of Pregnan
    Shao Lin; Fiscal Year: 2013
    ..on health, including its impact on morbidity, the joint effects of multiple weather factors, effects o extreme cold weather, and whether there are especially vulnerable subpopulations...
  17. Gordon Li; Fiscal Year: 2016
    ..and international meetings, including the Society for Neuro-Oncology, American Association for Cancer Research, Cold Spring Harbor Laboratory on Cancer Biology and Therapeutics, and Keystone Symposia meetings...
  18. NIH Director's Pioneer Award
    Karl Deisseroth; Fiscal Year: 2009
    ..abstract_text> ..
  19. Development of Montelukast Delivery System for Childhood Asthma
    Je Phil Ryoo; Fiscal Year: 2013
    ..bronchoconstriction and prevent many types of asthmatic responses, including allergen-induced, exercise- induced, cold-air-hyperventilation-induced, and aspirin-induced asthma (Wright et al 1998)...
  20. Cellular interactions in asthma
    CHRISTOPHER DAVID CABALLERO ALLEN; Fiscal Year: 2012
    ..that causes constriction of the airways in response to triggers such as pollen, mold, viral infection, or even cold air. In severe cases, the obstruction f the airways in asthma can be fatal...
  21. Toby C Lewis; Fiscal Year: 2014
    ..We have shown, in a prior epidemiologic study, that asthmatics with cold symptoms show more changes in lung function associated with prior exposure to high pollution than those without ..
  22. CSHL 2010 Conference on Molecular Genetics and Bacteria & Phages
    David J Stewart; Fiscal Year: 2010
    ..b>cold spring harbor laboratory conference on the molecular genetics of bacteria and phages august 24 - 28, 2010 project ..
  23. JOSHUA EMRICK; Fiscal Year: 2016
    ..g., ion channels) serves to delineate nociceptor subgroups (e.g., TRPV1/heat, TRPM8/cold, and TRPA1/chemical irritants) (Basbaum, Bautista et al. 2009)...
  24. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
    ..non-heart-beating donors, aged donors, donors with mild-to-moderate hypertension, or kidneys subjected to prolonged cold ischemia and exhibiting increased ischemia-normothermic reperfusion injury and delayed graft function, therefore ..
  25. 2012 CSHL Bacteria &Phages Conference
    David J Stewart; Fiscal Year: 2012
    ..DESCRIPTION (provided by applicant): The Molecular Genetics of Bacteria and Phages Conference, traditionally held at Cold Spring Harbor and now being held in alternate years at the University of Wisconsin in Madison and at the Cold ..
  26. Quantitative Assessment of Oxidative Metabolism in Brown Fat
    Otto Muzik; Fiscal Year: 2011
    ..organ that plays a critical role in non- shivering thermogenesis with the purpose of generating heat in response to cold stress...
  27. Age and Control of Human Skin Flow
    W Larry Kenney; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Humans over the age of 65 contribute disproportionately to cold- and heat-related morbidities and mortalities and the relative risk of death from all causes increases during cold and hot weather...
  28. Sympathetic Regulation of AMPK in the control of non-shivering thermogenesis
    Jacob D Mulligan; Fiscal Year: 2012
    ..This will be done in vivo by exposing wildtype and 23-adrenergic receptor knockout mice to 14 days of cold exposure or adrenergic receptor agonists administered via micro-osmotic pumps, and fractionating the white adipose ..
  29. Human hepatocytes for drug toxicity screening from Cardiac Death Donor livers
    Mark G Clemens; Fiscal Year: 2012
    ..are the extended periods of warm ischemia (WI) experienced by these organs and the preservation process, simple cold storage, which does not resuscitate these organs...
  30. CYCLE REGULATION IN THE SYMBIONT SINORHIZOBIUM MELILOTI
    KATHERINE ELISABETH GIBSON; Fiscal Year: 2011
    ..We aim to determine the precise timing of HK function during cell cycle progression. We will isolate conditional cold-sensitive HK alleles in order to rapidly deplete HK function at the non-permissive temperature and thereby pinpoint ..
  31. Jayakrishnan Nandakumar; Fiscal Year: 2015
    ..me to attend a cancer biology course, a telomerase-cancer AACR meeting, and a microscopy workshop conducted by Cold Spring Harbor labs. I have obtained formal training in the responsible conduct of research (RCR) during my Ph.D...
  32. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
    ..pathogens causing a wide range of clinical diseases ranging from relatively benign reactivated infections such as cold sores to more deadly cancers...
  33. Clinical Impact of Human Coronaviruses and Viral Diversity
    Geoffrey J Gorse; Fiscal Year: 2012
    ..The common cold, but also more severe illnesses involving the respiratory tract may result, including those similar to influenza ..
  34. Antonio C Bianco; Fiscal Year: 2014
    ..At the same time, disruption of the D2 pathway (D2KO) reduces cold-induced and also diet- induced brown adipose tissue (BAT) thermogenesis...
  35. Translational Immunology Research and Accelerated [vaccine] Development (TRIAD)
    ANNE SEARLS DEGROOT; Fiscal Year: 2013
    ..FT has been listed as a Category A biological warfare agent as a result of World War II and Cold War-era biowarfare research...
  36. CSHL Eukaryotic DNA Replication Conference
    David J Stewart; Fiscal Year: 2013
    ..Eukaryotic DNA Replication and Genome Maintenance and follows the highly successful meetings that have been held at Cold Spring Harbor every second year since September 1987...
  37. Wendy L Picking; Fiscal Year: 2014
    ..properties (the peptidoglycan envelope stimulates innate immunity), are highly stable (eliminating the need for cold chain), easy to manufacture and inexpensive...
  38. Andrew D Mesecar; Fiscal Year: 2016
    ..strand RNA viruses which cause a range of illness, from relatively mild respiratory disease (croup and common cold like symptoms due to HCoV- NL63, 229e or OC43) to severe acute respiratory syndrome (SARS) outbreaks in humans...
  39. The Regulation of Mitochondrial Function by SIRT3
    Qiang Tong; Fiscal Year: 2010
    ..that the expression of SIRT3, one of the seven mammalian Sir2 homologs, is increased by caloric restriction and cold exposure in brown adipose. We have also shown that murine SIRT3 is localized to the mitochondria inner membrane...
  40. Zhonghui Guan; Fiscal Year: 2016
    ..to gaining hands-on experience, I plan to take courses to study epigenetics and computational data analysis, at Cold Spring Harbor and at UC Berkeley...
  41. AREA: Rapamycin, ambient temperature, and longevity
    Steven J Swoap; Fiscal Year: 2010
    ..Most of the lifespan extension consequence of caloric restriction in mice requires a mild cold stress (i.e. a typical housing temperature of 220C)...
  42. 2011 EUKARYOTIC DNA REPLICATION &GENOME MAINTENANCE
    David J Stewart; Fiscal Year: 2011
    ..Eukaryotic DNA Replication and Genome Maintenance and follows the highly successful meetings that have been held at Cold Spring Harbor every second year since September 1987...
  43. Robert Seymour; Fiscal Year: 2015
    ..particularly VEEV, were developed as biological weapons by the United States Military and former USSR during the cold war and are potential bioterrorist threats due to their ease of transmission and infectivity by the aerosol route...
  44. Separation-of-function Mutants to Study the Biological Significance of Telomerase
    Jayakrishnan Nandakumar; Fiscal Year: 2012
    ..me to attend a cancer biology course, a telomerase-cancer AACR meeting, and a microscopy workshop conducted by Cold Spring Harbor labs. I have obtained formal training in the responsible conduct of research (RCR) during my Ph.D...
  45. XUDONG J LI; Fiscal Year: 2015
    ..problem and is the second most common reason that Americans go to see their doctor, second only to the most common cold and the flu...
  46. Henry Daniell; Fiscal Year: 2016
    ..for production and oral delivery of therapeutic protein antigens without a need for fermentation, purification, cold chain, or sterile injections...
  47. Shingo Kajimura; Fiscal Year: 2016
    ..Because brown adipose tissue (BAT) dissipates energy to produce heat as a defense against cold and obesity, altering the molecular pathway to increase the amount or thermogenic activity of BAT may lead to an ..
  48. Development and testing of polyvalent anthrax toxin inhibitors
    JEREMY S MOGRIDGE; Fiscal Year: 2012
    ..polyvalency provides a significant enhancement of potency;and 5) the PLGA-based inhibitors do not require a cold chain. The first aim of this proposal is to optimize the in vivo efficacy of polyvalent anthrax toxin inhibitors...
  49. Serotonergic Immunomodulation in Neuroinflammatory Disease
    CATHERINE ELIZABETH HAGAN; Fiscal Year: 2012
    ..Career development activities will include specialized courses, such as the Molecular Neuropathology course at Cold Spring Harbor, and regular didactic activities such as a journal clubs focused on microglial biology, inflammation, ..
  50. Role of HSV Induced RNA Degradation in Pathogenesis
    David A Leib; Fiscal Year: 2013
    ..In addition, HSV causes cold sores, genital sores, and is a leading cause of viral encephalitis...
  51. Oleg Alekseev; Fiscal Year: 2015
    ..HSV-1) is a ubiquitous pathogen that causes a wide range of human disease, including such well-known conditions as cold sores, keratoconjunctivitis, and encephalitis...
  52. JOSHUA ROBERT COOK; Fiscal Year: 2015
    ..Next, I will test the adipocyte browning response in A-FoxO1 mice by subjecting animals to cold (4oC), room temperature (22oC), or thermo neutrality (30oC) for various time periods and then performing gene-..
  53. CHRISTOPHER ANTHONY VAKULSKAS; Fiscal Year: 2014
    ..family of regulatory proteins, whose role in bacteria was thought to be limited to rRNA maturation during cold stress, and assisting secondary cleavage events in RNA turnover...
  54. Central Sympathetic Regulation of Thermogenesis in Fever
    Shaun F Morrison; Fiscal Year: 2013
    ..to the heart and to skin blood vessels and increased somatic motorneuron discharge to muscle, also constitutes the cold defense homeostatic reflex response to stimulation of cutaneous cold receptors or falls in core temperature...
  55. Short-term responses to temperature changes in Escherichia coli
    Christine A White Ziegler; Fiscal Year: 2010
    ..are the reactions to temperatures at the border of growth for these bacteria- the heat (42[unreadable]C) and cold shock (15[unreadable]C) responses...
  56. Mechanisms of Meditation in Hypertension in Blacks
    Robert Schneider; Fiscal Year: 2010
    ..Acute lab stressors will include mental arithmetic, cold pressor and exercise treadmill...
  57. Brown Adipose Tissue Vasculature Probes for Non-Invasive Imaging
    Mikhail G Kolonin; Fiscal Year: 2011
    ..of BAT, transdifferentiation of white adipocytes into brown adipocytes has been shown to take place in response to cold or other symphatetic nervous system stimuli in rodents...
  58. Ping Wang; Fiscal Year: 2016
    ..In this proposal, we will continue our discovery of a novel proinflammatory mediator/cytokine, cold-inducible RNA-binding protein (CIRP)...
  59. 2011 Cold Spring Harbor Conference on Telomeres and Telomerase
    David J Stewart; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cold Spring Harbor Laboratory Conference on Telomeres and Telomerase May 3-7, 2011. Telomeres are specialized protein-DNA complexes that protect the ends of eukaryotic chromosomes...
  60. Exploiting toxins to probe sensory signaling
    David Julius; Fiscal Year: 2012
    ..such as capsaicin (from chili peppers) and menthol (from mint leaves) to identify ion channels that detect heat and cold, respectively...
  61. David C Hooper; Fiscal Year: 2016
    ..In Shewanella algae, a reservoir of qnrA, we have further found cold shock to trigger qnrA expression, and we propose to test further conditions of expression in S...
  62. Cathespin K Radioligands for In Vivo Imaging
    Michael R Kilbourn; Fiscal Year: 2012
    ..that radioactivity localization is cathepsin-specific will be done in RANKL treated rats and blocking with cold doses of enzyme inhibitor...
  63. TERRI I GRODZICKER; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The Cold Spring Harbor Laboratory proposes to continue a course entitled Advanced Immunocytochemistry, In Situ Hybridization and Live Cell Imaging, to be held in the Fall of 2010-2014...
  64. MOLECULAR BASIS FOR ETHANOL-INDUCED HYPOTHYROIDISM
    Robert Zoeller; Fiscal Year: 1993
    ..hypothermia is associated with a potent suppression of thyroid activity, and the thyrotropic effect of acute cold exposure is blunted...
  65. New Solutions to Improve Islet Recovery after Machine Preservation of Pancreas
    Michael Taylor; Fiscal Year: 2009
    ..This exceeds the 16h documented to be the present clinical limits of safe, static cold storage of donor pancreata...
  66. AIR CONDITIONING BY THE TRACHEA--STIMULI AND MECHANISMS
    Mark Deffebach; Fiscal Year: 1993
    Exercise and hyperventilation with cold dry air (CDA) are important triggers of an asthmatic attack that affects 80% of asthmatics. Bronchoconstriction is also seen after CDA hyperventilation in normal subjects and experimental animals...
  67. Function of NALT in nasal immunization to heterotypic strains of influenza
    Troy D Randall; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cold adapted influenza vaccines (CAV) are live attenuated viruses that infect the upper respiratory tract, including the Nasal Associated Lymphoid Tissue (NALT)...
  68. A Better & Stable Cold High-Level Disinfectant Formulation for Medical Equipments
    RAJIV SATSANGI; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): We are developing a novel two-part cold high-level disinfecting/sterilization technology that will be ready to work by mixing in water, just minutes before use...
  69. IRON DEFICIENCY ANEMIA AND COMPENSATORY SNS ACTIVITY
    John Beard; Fiscal Year: 1991
    Iron deficient and anemic humans and rats fail to maintain body temperature when cold stressed. It is not clear from existing data how much of this thermoregulatory defect is secondary to the anemic associated with iron deficiency...
  70. ANIMAL MODELS OF COLD AIR-INDUCED AIRWAY DISEASE
    Michael Davis; Fiscal Year: 2004
    ..laboratory model of peripheral airway cooling and drying support the hypothesis that repeated hyperventilation with cold air can lead to airway injury and inflammation...
  71. CSHL Conference on Mouse Development, Genetics and Genomics
    David J Stewart; Fiscal Year: 2010
    ..The meeting series alternates between Cold Spring Harbor and a European venue, with the 2010 meeting to be held at the Cold Spring Harbor Laboratory...
  72. Treatment of Transplant Reperfusion with an Anti-CD47 Antibody
    PAMELA TOY MANNING; Fiscal Year: 2009
    ..best case scenario in which anti-CD47 mAb is administered to the donor rat and maintained throughout liver harvest, cold storage and reperfusion, with the worst case of no CD47 blockade...
  73. The Development of a Refrigerated Platelet Product
    HANS WANDALL; Fiscal Year: 2007
    ..Our long term aim is to develop a galactosylated and sialylated platelet product that can be stored in the cold in order to prolong shelf life and minimize risk of bacterial growth...
  74. Transgenic Mouse Model for the Common Cold
    Matthias Gromeier; Fiscal Year: 2009
    ..Despite the generally benign course of the common cold caused by picornaviruses, it is the main culprit for acute exacerbation of serious respiratory system disorders, ..
  75. EPIDEMIOLOGY OF RAYNAUD PHENOMENON
    HILDEGARD MARICQ; Fiscal Year: 1992
    ..or have more general validity, and more specifically to test the hypotheses that 1) RP is more prevalent in cold regions than in South Carolina, 2) cold is one of the etiological agents, not only a triggering factor for RP, 3) ..
  76. Neutron Microscope for In-Vivo Imaging
    JAY CREMER; Fiscal Year: 2005
    ..One particular clinical application for the thermal or cold neutron microscope that we will address in the proposed program is to provide a new imaging modality in boron ..
  77. APOPTOSIS INTERVENTION IN CELL AND ORGAN PRESERVATION
    Robert Van Buskirk; Fiscal Year: 1999
    ..BioLife's primary mission is to develop improved hypothermic (cold storage) solutions designed to maintain cells, tissues and organs in a near state of suspended animation at 4 ..
  78. THREE APPROACHES TO RAPID REMINERALIZATION OF THE TOOTH
    Ming Tung; Fiscal Year: 1992
    ..Three kinds of solutions with different concentrations and application methods will be used: (1) stable cold solutions containing maximum concentrations of calcium and phosphate under pressurized CO2 atmosphere...
  79. Flat Panel X-ray Sources for Small Animal Cardiac CT
    Mitali J More; Fiscal Year: 2010
    ..The DAXS uses an innovative architecture in which electrons from cold cathode arrays formed in pixel configurations on the source exit window generate x-ray flux at the target opposite...
  80. Assessment of MitoQ Therapy for Cold Preservation Renal Damage
    Kelvin G M Brockbank; Fiscal Year: 2010
    ..Long term renal function following transplantation has been shown to be better when kidneys are not subjected to cold preservation storage...