temperature

Summary

Top Publications

  1. ncbi Coral reefs under rapid climate change and ocean acidification
    O Hoegh-Guldberg
    Centre for Marine Studies, University of Queensland, St Lucia, 4072 Queensland, Australia
    Science 318:1737-42. 2007
  2. doi Optimal temperature for malaria transmission is dramatically lower than previously predicted
    Erin A Mordecai
    Ecology, Evolution, and Marine Biology Department, University of California, Santa Barbara, CA 93106, USA
    Ecol Lett 16:22-30. 2013
  3. pmc Temperature as a universal resetting cue for mammalian circadian oscillators
    Ethan D Buhr
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208 3520, USA
    Science 330:379-85. 2010
  4. ncbi The Paragon Algorithm, a next generation search engine that uses sequence temperature values and feature probabilities to identify peptides from tandem mass spectra
    Ignat V Shilov
    Applied Biosystems MDS Sciex, Foster City, CA 94404, USA
    Mol Cell Proteomics 6:1638-55. 2007
  5. ncbi Temperature sensitivity of soil carbon decomposition and feedbacks to climate change
    Eric A Davidson
    The Woods Hole Research Center, PO Box 296, Woods Hole, Massachusetts 02543, USA
    Nature 440:165-73. 2006
  6. pmc An internal thermal sensor controlling temperature preference in Drosophila
    Fumika N Hamada
    National Center for Behavioral Genomics, Volen Center for Complex Systems, Biology Department, Brandeis University MS 008, 415 South Street, Waltham, Massachusetts 02454, USA
    Nature 454:217-20. 2008
  7. doi One-third of reef-building corals face elevated extinction risk from climate change and local impacts
    Kent E Carpenter
    IUCN International Union for Conservation of Nature Species Programme Species Survival Commission SSC, Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA
    Science 321:560-3. 2008
  8. ncbi Effects of size and temperature on metabolic rate
    J F Gillooly
    Department of Biology, The University of New Mexico, Albuquerque, NM 87131, USA
    Science 293:2248-51. 2001
  9. pmc Climate change threats to plant diversity in Europe
    Wilfried Thuiller
    Centre d Ecologie Fonctionnelle et Evolutive, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5175, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 102:8245-50. 2005
  10. pmc Metagenomes from high-temperature chemotrophic systems reveal geochemical controls on microbial community structure and function
    William P Inskeep
    Thermal Biology Institute and Department of Land Resources and Environmental Sciences, Montana State University, Bozeman, Montana, United States of America
    PLoS ONE 5:e9773. 2010

Research Grants

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
  2. PHILIP LEE JOHNSON; Fiscal Year: 2016
  3. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
  4. Jian Min Yuan; Fiscal Year: 2014
  5. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
  6. John H Postlethwait; Fiscal Year: 2016
  7. Intracellular Phase Diagram Creation Using a Micro-Differential Scanning Calorime
    GARY L SOLBREKKEN; Fiscal Year: 2010
  8. Alzheimer's Disease Therapeutic
    Trevor P Castor; Fiscal Year: 2012
  9. Ghrelin: Behavioral, Anatomical, and Physiological Components of Obesity
    BRETT JOHN WARREN TEUBNER; Fiscal Year: 2011
  10. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012

Detail Information

Publications440 found, 100 shown here

  1. ncbi Coral reefs under rapid climate change and ocean acidification
    O Hoegh-Guldberg
    Centre for Marine Studies, University of Queensland, St Lucia, 4072 Queensland, Australia
    Science 318:1737-42. 2007
    ..As the International Year of the Reef 2008 begins, scaled-up management intervention and decisive action on global emissions are required if the loss of coral-dominated ecosystems is to be avoided...
  2. doi Optimal temperature for malaria transmission is dramatically lower than previously predicted
    Erin A Mordecai
    Ecology, Evolution, and Marine Biology Department, University of California, Santa Barbara, CA 93106, USA
    Ecol Lett 16:22-30. 2013
    ..Most malaria models to date assume constant or linear responses of mosquito and parasite life-history traits to temperature, predicting optimal transmission at 31 °C...
  3. pmc Temperature as a universal resetting cue for mammalian circadian oscillators
    Ethan D Buhr
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208 3520, USA
    Science 330:379-85. 2010
    Environmental temperature cycles are a universal entraining cue for all circadian systems at the organismal level with the exception of homeothermic vertebrates...
  4. ncbi The Paragon Algorithm, a next generation search engine that uses sequence temperature values and feature probabilities to identify peptides from tandem mass spectra
    Ignat V Shilov
    Applied Biosystems MDS Sciex, Foster City, CA 94404, USA
    Mol Cell Proteomics 6:1638-55. 2007
    ..Sequence Temperature Values are computed using a sequence tag algorithm, allowing the degree of implication by an MS/MS spectrum of ..
  5. ncbi Temperature sensitivity of soil carbon decomposition and feedbacks to climate change
    Eric A Davidson
    The Woods Hole Research Center, PO Box 296, Woods Hole, Massachusetts 02543, USA
    Nature 440:165-73. 2006
    ..Despite much research, a consensus has not yet emerged on the temperature sensitivity of soil carbon decomposition...
  6. pmc An internal thermal sensor controlling temperature preference in Drosophila
    Fumika N Hamada
    National Center for Behavioral Genomics, Volen Center for Complex Systems, Biology Department, Brandeis University MS 008, 415 South Street, Waltham, Massachusetts 02454, USA
    Nature 454:217-20. 2008
    Animals from flies to humans are able to distinguish subtle gradations in temperature and show strong temperature preferences...
  7. doi One-third of reef-building corals face elevated extinction risk from climate change and local impacts
    Kent E Carpenter
    IUCN International Union for Conservation of Nature Species Programme Species Survival Commission SSC, Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA
    Science 321:560-3. 2008
    ..Our results emphasize the widespread plight of coral reefs and the urgent need to enact conservation measures...
  8. ncbi Effects of size and temperature on metabolic rate
    J F Gillooly
    Department of Biology, The University of New Mexico, Albuquerque, NM 87131, USA
    Science 293:2248-51. 2001
    ..a general model, based on principles of biochemical kinetics and allometry, that characterizes the effects of temperature and body mass on metabolic rate...
  9. pmc Climate change threats to plant diversity in Europe
    Wilfried Thuiller
    Centre d Ecologie Fonctionnelle et Evolutive, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5175, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 102:8245-50. 2005
    ..and turnover were found to depend strongly on the degree of change in just two climate variables describing temperature and moisture conditions...
  10. pmc Metagenomes from high-temperature chemotrophic systems reveal geochemical controls on microbial community structure and function
    William P Inskeep
    Thermal Biology Institute and Department of Land Resources and Environmental Sciences, Montana State University, Bozeman, Montana, United States of America
    PLoS ONE 5:e9773. 2010
    ..contains the most numerous and diverse geothermal systems on Earth, yielding an extensive array of unique high-temperature environments that host a variety of deeply-rooted and understudied Archaea, Bacteria and Eukarya...
  11. ncbi The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
    Frank H Niesen
    Structural Genomics Consortium, Botnar Research Centre, Oxford University, Oxford, UK
    Nat Protoc 2:2212-21. 2007
    ..The temperature at which a protein unfolds is measured by an increase in the fluorescence of a dye with affinity for ..
  12. ncbi Arabidopsis, the Rosetta stone of flowering time?
    Gordon G Simpson
    Department of Cell and Developmental Biology, John Innes Centre, Norwich, NR4 7UH, UK
    Science 296:285-9. 2002
    ..This framework provides the basis to understand the evolution of different reproductive strategies and how floral pathways interact through seasonal progression...
  13. ncbi Dengue virus-mosquito interactions
    Scott B Halstead
    Pediatric Dengue Vaccine Initiative, Bethesda, MD 20852, USA
    Annu Rev Entomol 53:273-91. 2008
    ..presents and discusses information on mosquito-dengue infection dynamics and describes the prominent role that temperature and rainfall play in controlling dengue viral transmission including discussions of the effect of interannual ..
  14. pmc Distributed lag non-linear models
    A Gasparrini
    Public Health and Policy Department, London School of Hygiene and Tropical Medicine, Keppel Street, London W1C 7HT, U K
    Stat Med 29:2224-34. 2010
    ..To illustrate the methodology we use examples of DLNMs to represent the relationship between temperature and mortality, using data from the National Morbidity, Mortality, and Air Pollution Study (NMMAPS) for New York ..
  15. pmc Systematic variation in the temperature dependence of physiological and ecological traits
    Anthony I Dell
    Department of Biomathematics, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
    Proc Natl Acad Sci U S A 108:10591-6. 2011
    To understand the effects of temperature on biological systems, we compile, organize, and analyze a database of 1,072 thermal responses for microbes, plants, and animals...
  16. ncbi Impact of climate change on marine pelagic phenology and trophic mismatch
    Martin Edwards
    Sir Alister Hardy Foundation for Ocean Science, The Laboratory, Citadel Hill, Plymouth PL1 2PB, UK
    Nature 430:881-4. 2004
    ....
  17. ncbi Giant tunnelling magnetoresistance at room temperature with MgO (100) tunnel barriers
    Stuart S P Parkin
    IBM Research Division, IBM Almaden Research Center, IBM Infineon MRAM Development Alliance, 650 Harry Road, San Jose, California 95120, USA
    Nat Mater 3:862-7. 2004
    ..The performance of these devices is currently limited by the modest (< approximately 70%) room-temperature tunnelling magnetoresistance (TMR) of technologically relevant MTJs...
  18. doi UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    Helena M Feldmann
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    Cell Metab 9:203-9. 2009
    ..We conclude that ambient temperature is qualitatively determinative for the outcome of metabolic studies, that no other protein and no other ..
  19. pmc Association between climate variability and malaria epidemics in the East African highlands
    Guofa Zhou
    Department of Biological Sciences, State University of New York, Buffalo, NY 14260, USA
    Proc Natl Acad Sci U S A 101:2375-80. 2004
    ..as short-term fluctuations around the mean climate state, may be epidemiologically more relevant than mean temperature change, but its effects on malaria epidemics have not been rigorously examined...
  20. ncbi Widespread amphibian extinctions from epidemic disease driven by global warming
    J Alan Pounds
    Golden Toad Laboratory for Conservation, Monteverde Cloud Forest Preserve and Tropical Science Center, Santa Elena, Puntarenas 5655 73, Costa Rica
    Nature 439:161-7. 2006
    ..With climate change promoting infectious disease and eroding biodiversity, the urgency of reducing greenhouse-gas concentrations is now undeniable...
  21. pmc Impacts of climate warming on terrestrial ectotherms across latitude
    Curtis A Deutsch
    Program on Climate Change and Department of Oceanography and Department of Biology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:6668-72. 2008
    ..Yet the biological impact of rising temperatures also depends on the physiological sensitivity of organisms to temperature change...
  22. doi Profiling gene expression responses of coral larvae (Acropora millepora) to elevated temperature and settlement inducers using a novel RNA-Seq procedure
    E Meyer
    Integrative Biology Section, The University of Texas at Austin, Austin, TX 78712, USA
    Mol Ecol 20:3599-616. 2011
    ..Future studies of gene expression in corals will have to address this genetic variation, which could have important adaptive consequences for corals during global climate change...
  23. ncbi Temperature and mortality in 11 cities of the eastern United States
    Frank C Curriero
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 155:80-7. 2002
    ..Time-series analyses show an association between temperature and mortality across a range of less extreme temperatures...
  24. ncbi Design of a novel globular protein fold with atomic-level accuracy
    Brian Kuhlman
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Science 302:1364-8. 2003
    ..2 angstroms) to the design model. The ability to design a new protein fold makes possible the exploration of the large regions of the protein universe not yet observed in nature...
  25. pmc The influence of mosquito resting behaviour and associated microclimate for malaria risk
    Krijn P Paaijmans
    Center for Infectious Disease Dynamics and Department of Entomology, Merkle Lab, Penn State University, University Park, PA 16802, USA
    Malar J 10:183. 2011
    ..of the mosquito and parasite life-history traits that combine to determine malaria transmission intensity are temperature sensitive...
  26. ncbi Heterotrophic plasticity and resilience in bleached corals
    Andréa G Grottoli
    Department of Geological Sciences, Ohio State University, Columbus, Ohio 43210, USA
    Nature 440:1186-9. 2006
    ....
  27. pmc Understanding the link between malaria risk and climate
    Krijn P Paaijmans
    Center for Infectious Disease Dynamics, Department of Entomology, Chemical Ecology Laboratory, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 106:13844-9. 2009
    The incubation period for malaria parasites within the mosquito is exquisitely temperature-sensitive, so that temperature is a major determinant of malaria risk...
  28. doi Global patterns and predictors of marine biodiversity across taxa
    Derek P Tittensor
    Department of Biology, Dalhousie University, 1355 Oxford Street, Halifax B3H 4J1, Canada
    Nature 466:1098-101. 2010
    ..Spatial regression analyses revealed sea surface temperature as the only environmental predictor highly related to diversity across all 13 taxa...
  29. pmc North American West Nile virus genotype isolates demonstrate differential replicative capacities in response to temperature
    Christy C Andrade
    Center for Vector Borne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, USA
    J Gen Virol 92:2523-33. 2011
    ..embryonic fibroblast (DEF) cell lines at differing, biologically relevant temperatures to assess the relative temperature sensitivities of these natural isolates...
  30. pmc Effects of temperature on emergence and seasonality of West Nile virus in California
    David M Hartley
    Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    Am J Trop Med Hyg 86:884-94. 2012
    b>Temperature has played a critical role in the spatiotemporal dynamics of West Nile virus transmission throughout California from its introduction in 2003 through establishment by 2009...
  31. pmc Forecast of dengue incidence using temperature and rainfall
    Yien Ling Hii
    Umeå Centre for Global Health Research, Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
    PLoS Negl Trop Dis 6:e1908. 2012
    ..The aim of this study was to develop and validate a forecasting model that could predict dengue cases and provide timely early warning in Singapore...
  32. doi The physiology of climate change: how potentials for acclimatization and genetic adaptation will determine 'winners' and 'losers'
    G N Somero
    Hopkins Marine Station, Department of Biology, Stanford University, Pacific Grove, CA 93950, USA
    J Exp Biol 213:912-20. 2010
    ..genes and gene regulatory mechanisms--influence capacities for adapting to acute and long-term increases in temperature. Studies of congeneric invertebrates from thermally stressful rocky intertidal habitats have shown that warm-..
  33. pmc Peripheral protein quality control removes unfolded CFTR from the plasma membrane
    Tsukasa Okiyoneda
    Department of Physiology, and Groupe de Recherche Axé sur la Structure des Protéine GRASP McGill University, Montreal, Quebec H3G 1Y6, Canada
    Science 329:805-10. 2010
    ....
  34. pmc Development of a new version of the Liverpool Malaria Model. I. Refining the parameter settings and mathematical formulation of basic processes based on a literature review
    Volker Ermert
    Institute of Geophysics and Meteorology, University of Cologne, Cologne, Germany
    Malar J 10:35. 2011
    ..The Liverpool Malaria Model (LMM) is a mathematical-biological model of malaria parasite dynamics using daily temperature and precipitation data...
  35. doi The effect of temperature on mortality in rural Bangladesh--a population-based time-series study
    Masahiro Hashizume
    Institute of Tropical Medicine, Nagasaki University, 1 12 4, Sakamoto, Nagasaki 852 8523, Japan
    Int J Epidemiol 38:1689-97. 2009
    ..However, few studies have examined temperature-mortality relationship in the rural areas of developing countries...
  36. pmc The impact of temperature on mortality in Tianjin, China: a case-crossover design with a distributed lag nonlinear model
    Yuming Guo
    School of Public Health, Queensland University of Technology, Brisbane, Australia
    Environ Health Perspect 119:1719-25. 2011
    Although interest in assessing the impacts of temperature on mortality has increased, few studies have used a case-crossover design to examine nonlinear and distributed lag effects of temperature on mortality...
  37. pmc Drought, salt, and temperature stress-induced metabolic rearrangements and regulatory networks
    Julia Krasensky
    GMI Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
    J Exp Bot 63:1593-608. 2012
    ..In this review, information about metabolic regulation in response to drought, extreme temperature, and salinity stress is summarized and the signalling events involved in mediating stress-induced metabolic ..
  38. ncbi Climate change and distribution shifts in marine fishes
    Allison L Perry
    Centre for Ecology, Evolution and Conservation, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Science 308:1912-5. 2005
    ..of both exploited and nonexploited North Sea fishes have responded markedly to recent increases in sea temperature, with nearly two-thirds of species shifting in mean latitude or depth or both over 25 years...
  39. ncbi Influence of temperature on immature development, survival, longevity, fecundity, and gonotrophic cycles of Aedes albopictus, vector of chikungunya and dengue in the Indian Ocean
    H Delatte
    Research Unit 016, Institut de recherche pour le developpement IRD, 7 chemin de l IRAT, 97410 Saint Pierre, La Reunion, France
    J Med Entomol 46:33-41. 2009
    ..5 d). Those results are according to the field repartition of this species in La Réunion, allowing Ae. albopictus survival at a large range of temperatures...
  40. ncbi Coral reefs: corals' adaptive response to climate change
    Andrew C Baker
    Marine Program, Wildlife Conservation Society, Bronx, New York 10460, USA
    Nature 430:741. 2004
    ..that corals containing unusual algal symbionts that are thermally tolerant and commonly associated with high-temperature environments are much more abundant on reefs that have been severely affected by recent climate change...
  41. doi Climate. Blooms like it hot
    Hans W Paerl
    Institute of Marine Sciences, University of North Carolina at Chapel Hill, Morehead City, NC 28557, USA
    Science 320:57-8. 2008
  42. pmc Identification and importance of brown adipose tissue in adult humans
    Aaron M Cypess
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    N Engl J Med 360:1509-17. 2009
    ....
  43. pmc Implications of temperature variation for malaria parasite development across Africa
    J I Blanford
    GeoVISTA Center, Department of Geography, The Pennsylvania State University, University Park, PA, USA
    Sci Rep 3:1300. 2013
    b>Temperature is an important determinant of malaria transmission. Recent work has shown that mosquito and parasite biology are influenced not only by average temperature, but also by the extent of the daily temperature variation...
  44. ncbi Thermofluor-based high-throughput stability optimization of proteins for structural studies
    Ulrika B Ericsson
    Department of Biochemistry and Biophysics, Stockholm University, Stockholm SE 109 51, Sweden
    Anal Biochem 357:289-98. 2006
    ..This suggests that thermofluor constitutes an efficient generic high-throughput method for identification of protein properties predictive of crystallizability...
  45. pmc Temperature, viral genetics, and the transmission of West Nile virus by Culex pipiens mosquitoes
    A Marm Kilpatrick
    Consortium for Conservation Medicine, New York, New York, United States of America
    PLoS Pathog 4:e1000092. 2008
    ..Vector competence, in turn, can be influenced by temperature and viral genetics...
  46. doi A review of the likely effects of climate change on anadromous Atlantic salmon Salmo salar and brown trout Salmo trutta, with particular reference to water temperature and flow
    B Jonsson
    Norwegian Institute for Nature Research, Gaustadalleen 21, N 0349 Oslo, Norway
    J Fish Biol 75:2381-447. 2009
    The present paper reviews the effects of water temperature and flow on migrations, embryonic development, hatching, emergence, growth and life-history traits in light of the ongoing climate change with emphasis on anadromous Atlantic ..
  47. pmc DNA methylation of the gonadal aromatase (cyp19a) promoter is involved in temperature-dependent sex ratio shifts in the European sea bass
    Laia Navarro-Martín
    Institut de Ciencies del Mar, Consejo Superior de Investigaciones Cientificas CSIC, Barcelona, Spain
    PLoS Genet 7:e1002447. 2011
    Sex ratio shifts in response to temperature are common in fish and reptiles. However, the mechanism linking temperature during early development and sex ratios has remained elusive...
  48. pmc Reduction of Aedes aegypti vector competence for dengue virus under large temperature fluctuations
    Lauren B Carrington
    Department of Entomology, University of California, Davis, CA95616, USA
    Am J Trop Med Hyg 88:689-97. 2013
    Diurnal temperature fluctuations can fundamentally alter mosquito biology and mosquito-virus interactions in ways that impact pathogen transmission...
  49. ncbi Global control of dimorphism and virulence in fungi
    Julie C Nemecek
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Science 312:583-8. 2006
    ..switch from nonpathogenic molds in soil to pathogenic yeast after spores are inhaled and exposed to elevated temperature. Mechanisms that regulate this switch remain obscure...
  50. doi Global warming, elevational range shifts, and lowland biotic attrition in the wet tropics
    Robert K Colwell
    Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA
    Science 322:258-61. 2008
    ..at temperate latitudes, but evidence for range shifts is scarce for the tropics, where the shallow latitudinal temperature gradient makes upslope shifts more likely than poleward shifts...
  51. doi Time series analysis of Japanese encephalitis and weather in Linyi City, China
    Hualiang Lin
    School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong SAR, China
    Int J Public Health 57:289-96. 2012
    ..To examine the relationship between meteorological factors and epidemiological pattern of Japanese encephalitis in Linyi City during 1956-2004...
  52. pmc High temperature (30 degrees C) blocks aerosol but not contact transmission of influenza virus
    Anice C Lowen
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 82:5650-2. 2008
    ..Our data imply that contact or short-range spread predominates in the tropics and offer an explanation for the lack of a well-defined, recurrent influenza season affecting tropical and subtropical regions of the world...
  53. pmc Larval environmental temperature and the susceptibility of Aedes albopictus Skuse (Diptera: Culicidae) to Chikungunya virus
    Catherine J Westbrook
    Florida Medical Entomology Laboratory, Department of Entomology and Nematology, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, Florida 32962, USA
    Vector Borne Zoonotic Dis 10:241-7. 2010
    ..Adult females with the largest body size were produced from the coolest temperature, took the longest to mature, and six times more likely to be infected with CHIKV than females reared at 32 ..
  54. doi Ecologically relevant measures of tolerance to potentially lethal temperatures
    John S Terblanche
    Department of Conservation Ecology and Entomology, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa
    J Exp Biol 214:3713-25. 2011
    ..An important area for further development is to identify the impact of rates of temperature change under field and laboratory conditions.
  55. ncbi Climate warming and disease risks for terrestrial and marine biota
    C Drew Harvell
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA
    Science 296:2158-62. 2002
    ..Many pathogens of terrestrial and marine taxa are sensitive to temperature, rainfall, and humidity, creating synergisms that could affect biodiversity...
  56. ncbi Models for the relationship between ambient temperature and daily mortality
    Ben Armstrong
    London School of Hygiene and Tropical Medicine, London, UK
    Epidemiology 17:624-31. 2006
    Ambient temperature is an important determinant of daily mortality that is of interest both in its own right and as a confounder of other determinants investigated using time-series regressions, in particular, air pollution...
  57. doi Forests and climate change: forcings, feedbacks, and the climate benefits of forests
    Gordon B Bonan
    National Center for Atmospheric Research, P O Box 3000, Boulder, Colorado 80307, USA
    Science 320:1444-9. 2008
    ....
  58. pmc The single-nucleotide resolution transcriptome of Pseudomonas aeruginosa grown in body temperature
    Omri Wurtzel
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    PLoS Pathog 8:e1002945. 2012
    ..aeruginosa grown at 28°C and 37°C we detected genes preferentially expressed at the body temperature of mammalian hosts, suggesting that they play a role during infection...
  59. ncbi Coral bleaching: thermal adaptation in reef coral symbionts
    Rob Rowan
    University of Guam Marine Laboratory, Mangilao, Guam 96923, USA
    Nature 430:742. 2004
    Many corals bleach as a result of increased seawater temperature, which causes them to lose their vital symbiotic algae (Symbiodinium spp...
  60. pmc Membrane lipids of symbiotic algae are diagnostic of sensitivity to thermal bleaching in corals
    Dan Tchernov
    Environmental Biophysics and Molecular Ecology Program, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, 71 Dudley Road, New Brunswick, NJ 08901, USA
    Proc Natl Acad Sci U S A 101:13531-5. 2004
    ..Although the phenomenon is correlated with relatively small increases in sea-surface temperature and enhanced light intensity, the underlying physiological mechanism remains unknown...
  61. doi Proteomics applied on plant abiotic stresses: role of heat shock proteins (HSP)
    Anna Maria Timperio
    Department of Environmental Sciences, University of Tuscia, Largo dell Università snc, 01100 Viterbo, Italy
    J Proteomics 71:391-411. 2008
    ....
  62. doi H2A.Z-containing nucleosomes mediate the thermosensory response in Arabidopsis
    S Vinod Kumar
    John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Cell 140:136-47. 2010
    Plants are highly sensitive to temperature and can perceive a difference of as little as 1 degrees C. How temperature is sensed and integrated in development is unknown...
  63. ncbi Conditional modification of behavior in Drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons
    T Kitamoto
    Division of Neurosciences, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, California 91010, USA
    J Neurobiol 47:81-92. 2001
    ..In this method, a temperature-sensitive allele of shibire (shi(ts1)) is overexpressed in neuronal subsets using the GAL4/UAS system...
  64. pmc N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa
    Edwin A Yates
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Infect Immun 70:5635-46. 2002
    ..Raising the temperature from 22 to 37 degrees C increased the rate of ring opening...
  65. doi International study of temperature, heat and urban mortality: the 'ISOTHURM' project
    Anthony J McMichael
    National Centre for Epidemiology and Population Health, The Australian National University College of Medicine and Health Sciences, Canberra, Australia
    Int J Epidemiol 37:1121-31. 2008
    This study describes heat- and cold-related mortality in 12 urban populations in low- and middle-income countries, thereby extending knowledge of how diverse populations, in non-OECD countries, respond to temperature extremes.
  66. pmc Influence of climate on malaria transmission depends on daily temperature variation
    Krijn P Paaijmans
    Department of Entomology, Center for Infectious Disease Dynamics, Penn State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 107:15135-9. 2010
    Malaria transmission is strongly influenced by environmental temperature, but the biological drivers remain poorly quantified...
  67. ncbi Evolution and biogeography of deep-sea vent and seep invertebrates
    C L Van Dover
    Biology Department, College of William and Mary, Williamsburg, VA 23187, USA
    Science 295:1253-7. 2002
    ..The recent evolution of many vent and seep invertebrate species (<100 million years ago) suggests that Cenozoic tectonic history and oceanic circulation patterns have been important in defining contemporary biogeographic patterns...
  68. ncbi Rapid changes in flowering time in British plants
    A H Fitter
    Department of Biology, University of York, York YO10 5DD, UK
    Science 296:1689-91. 2002
    ..Flowering is especially sensitive to the temperature in the previous month, and spring-flowering species are most responsive...
  69. ncbi Effect of primer mismatch, annealing temperature and PCR cycle number on 16S rRNA gene-targetting bacterial community analysis
    Rita Sipos
    Department of Microbiology, Eötvös Loránd University of Science, Budapest, Hungary
    FEMS Microbiol Ecol 60:341-50. 2007
    ..investigated using 'universal' bacteria-specific primers, focusing on the effect of primer mismatch, annealing temperature and PCR cycle number...
  70. pmc Ocean acidification causes bleaching and productivity loss in coral reef builders
    K R N Anthony
    Centre for Marine Studies, The University of Queensland, St Lucia 4072 Queensland, Australia
    Proc Natl Acad Sci U S A 105:17442-6. 2008
    ..Our findings suggest that sensitive reef-building species such as CCA may be pushed beyond their thresholds for growth and survival within the next few decades whereas corals will show delayed and mixed responses...
  71. ncbi Trends, rhythms, and aberrations in global climate 65 Ma to present
    J Zachos
    Earth Sciences Department, University of California, Santa Cruz, CA 95064, USA
    Science 292:686-93. 2001
    ..We also consider how this improved perspective has led to the recognition of previously unforeseen mechanisms for altering climate...
  72. pmc Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
    Masoud Vedadi
    Structural Genomics Consortium, University of Toronto, 100 College Street, Toronto, ON, Canada M5G 1L5
    Proc Natl Acad Sci U S A 103:15835-40. 2006
    ..The methods are cost-effective, can be implemented in any laboratory, promise to increase the success rates of purifying and crystallizing human proteins significantly, and identify new ligands for these proteins...
  73. ncbi Climate change affects marine fishes through the oxygen limitation of thermal tolerance
    Hans O Portner
    Alfred Wegener Institute for Polar and Marine Research, Animal Ecophysiology, Postfach 12 01 61, 27515 Bremerhaven, Germany
    Science 315:95-7. 2007
    ..Decrements in aerobic performance in warming seas will thus be the first process to cause extinction or relocation to cooler waters...
  74. doi Attributing physical and biological impacts to anthropogenic climate change
    Cynthia Rosenzweig
    NASA Goddard Institute for Space Studies and Columbia Center for Climate Systems Research, 2800 Broadway, New York, New York 10025, USA
    Nature 453:353-7. 2008
    ..Most of these changes are in the direction expected with warming temperature. Here we show that these changes in natural systems since at least 1970 are occurring in regions of observed ..
  75. pmc Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels
    Jing Yao
    Department of Physiology and Biophysical Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Proc Natl Acad Sci U S A 108:11109-14. 2011
    The molecular basis of the thermal sensitivity of temperature-sensitive channels appears to arise from a specific protein domain rather than integration of global thermal effects...
  76. pmc Long-term monitoring of fresco paintings in the cathedral of Valencia (Spain) through humidity and temperature sensors in various locations for preventive conservation
    Manuel Zarzo
    Department of Applied Statistics, Operations Research and Quality, Universidad Politecnica de Valencia, Camino de Vera s n, 46022 Valencia, Spain
    Sensors (Basel) 11:8685-710. 2011
    ..This system comprises 29 relative humidity (RH) and temperature sensors: 10 of them inserted into the plaster layer supporting the fresco paintings, 10 sensors in the walls ..
  77. ncbi Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans
    H Komatsu
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Neuron 17:707-18. 1996
    The C. elegans tax-4 mutants are abnormal in multiple sensory behaviors: they fail to respond to temperature or to water-soluble or volatile chemical attractants...
  78. ncbi Product differentiation by analysis of DNA melting curves during the polymerase chain reaction
    K M Ririe
    Idaho Technology Inc, Idaho Falls 83402, USA
    Anal Biochem 245:154-60. 1997
    ..Plotting fluorescence as a function of temperature as the thermal cycler heats through the dissociation temperature of the product gives a DNA melting curve...
  79. ncbi Hsp90 as a capacitor for morphological evolution
    S L Rutherford
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
    Nature 396:336-42. 1998
    ..When Hsp90 buffering is compromised, for example by temperature, cryptic variants are expressed and selection can lead to the continued expression of these traits, even when ..
  80. ncbi Dissecting the architecture of a quantitative trait locus in yeast
    Lars M Steinmetz
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 416:326-30. 2002
    ..It also demonstrates a deficiency in current approaches to QTL dissection with implications extending to traits in other organisms, including human genetic diseases...
  81. doi Is hand, foot and mouth disease associated with meteorological parameters?
    E Ma
    Surveillance and Epidemiology Branch, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region
    Epidemiol Infect 138:1779-88. 2010
    ..After adjusting for the effect of collinearity, mean temperature, diurnal difference in temperature, relative humidity, and wind speed were positively associated with HFMD ..
  82. pmc Climate-based models for understanding and forecasting dengue epidemics
    Elodie Descloux
    UMR190, Emergence of Viral Pathologies, Institute of Research for the Development, Aix Marseille University, Marseille, France
    PLoS Negl Trop Dis 6:e1470. 2012
    ..The objectives of this study were to analyze and model the relationships between climate, Aedes aegypti vectors and dengue outbreaks in Noumea (New Caledonia), and to provide an early warning system...
  83. pmc Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases
    J S Robinson
    Division of Biology, California Institute of Technology, Pasadena 91125
    Mol Cell Biol 8:4936-48. 1988
    ..vpt16, vpt18, vpt29, and vpt33) contained alleles that led to a conditional lethal phenotype; the mutants were temperature sensitive for vegetative cell growth...
  84. ncbi Different trajectories of parallel evolution during viral adaptation
    H A Wichman
    Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA
    Science 285:422-4. 1999
    ..However, the order of these changes differed between replicates, and parallel substitutions did not reflect the changes with the largest beneficial effects or indicate a common trajectory of adaptation...
  85. ncbi Impact of nitrogen deposition on the species richness of grasslands
    Carly J Stevens
    Department of Earth Sciences, The Open University, Milton Keynes MK7 6AA, UK
    Science 303:1876-9. 2004
    ..At the mean chronic nitrogen deposition rate of central Europe (17 kg Nha-1 year-1), there is a 23% species reduction compared with grasslands receiving the lowest levels of nitrogen deposition...
  86. doi Growth, activity and temperature responses of ammonia-oxidizing archaea and bacteria in soil microcosms
    Maria Tourna
    School of Biological Sciences, University of Aberdeen, Cruickshank Building, St Machar Drive, Aberdeen AB24 3UU, UK
    Environ Microbiol 10:1357-64. 2008
    ..In this study, we have determined the influence of temperature on the response of ammonia-oxidizing bacteria and archaea in nitrifying soil microcosms using two approaches, ..
  87. doi Declining coral calcification on the Great Barrier Reef
    Glenn De'ath
    Australian Institute of Marine Science, Townsville, Queensland 4810, Australia
    Science 323:116-9. 2009
    ..Calcification increases linearly with increasing large-scale sea surface temperature but responds nonlinearly to annual temperature anomalies...
  88. pmc Optimized molecular dynamics force fields applied to the helix-coil transition of polypeptides
    Robert B Best
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U K
    J Phys Chem B 113:9004-15. 2009
    ..However, despite the agreement at ambient conditions, the dependence of the helix content on temperature is too weak, a problem shared with other force fields...
  89. doi The influence of temperature and humidity on the incidence of hand, foot, and mouth disease in Japan
    Daisuke Onozuka
    Department of Public Health and Medical Affairs, Fukuoka Prefectural Government, 7 7 Higashi koen, Hakata Ku, Fukuoka shi, Fukuoka 812 8577, Japan
    Sci Total Environ 410:119-25. 2011
    ..However, the impact of weather fluctuations on hand, foot, and mouth disease (HFMD), which primarily affects children, is not well understood...
  90. doi Warming experiments underpredict plant phenological responses to climate change
    E M Wolkovich
    Division of Biological Sciences, University of California San Diego, 9500 Gilman Drive 0116, La Jolla, California 92093, USA
    Nature 485:494-7. 2012
    ..to provide meaningful predictions of future responses, they should reflect the empirical record of responses to temperature variability and recent warming, including advances in the timing of flowering and leafing...
  91. pmc Perception of climate change
    James Hansen
    National Aeronautics and Space Administration Goddard Institute for Space Studies, New York, NY 10025, USA
    Proc Natl Acad Sci U S A 109:E2415-23. 2012
    ..The distribution of seasonal mean temperature anomalies has shifted toward higher temperatures and the range of anomalies has increased...
  92. doi Rapid folding of DNA into nanoscale shapes at constant temperature
    Jean Philippe J Sobczak
    Physics Department, Walter Schottky Institute, Technische Universitat Munchen, Am Coulombwall 4a, 85748 Garching near Munich, Germany
    Science 338:1458-61. 2012
    We demonstrate that, at constant temperature, hundreds of DNA strands can cooperatively fold a long template DNA strand within minutes into complex nanoscale objects...
  93. pmc Simultaneous femtosecond X-ray spectroscopy and diffraction of photosystem II at room temperature
    Jan Kern
    Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Science 340:491-5. 2013
    ..diffraction (XRD) and x-ray emission spectroscopy (XES) of microcrystals of photosystem II (PS II) at room temperature. This method probes the overall protein structure and the electronic structure of the Mn4CaO5 cluster in the ..
  94. pmc Structural changes in dengue virus when exposed to a temperature of 37°C
    Guntur Fibriansah
    Program in Emerging Infectious Diseases, Duke NUS Graduate Medical School, Singapore
    J Virol 87:7585-92. 2013
    ..fully hidden epitope suggest that insect cell-derived dengue virus undergoes structural changes at an elevated temperature. This was confirmed by our cryo-electron microscopy images of dengue virus incubated at 37°C, where viruses ..
  95. pmc Fat cells directly sense temperature to activate thermogenesis
    Li Ye
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:12480-5. 2013
    ..indirectly through the sympathetic nervous systems and β-adrenergic signaling, but here we report that cool temperature (27-33 °C) can directly activate a thermogenic gene program in adipocytes in a cell-autonomous manner...
  96. pmc Temperature triggers immune evasion by Neisseria meningitidis
    Edmund Loh
    Sir William Dunn School of Pathology, University of Oxford, Sir Parks Road, Oxford OX1 3RE, UK
    Nature 502:237-40. 2013
    ..meningococcal immune evasion and resistance against complement increase in response to an increase in ambient temperature. We have identified three independent RNA thermosensors located in the 5' untranslated regions of genes ..
  97. ncbi Effect of temperature on the development of the aquatic stages of Anopheles gambiae sensu stricto (Diptera: Culicidae)
    M N Bayoh
    School of Biological and Biomedical Sciences Science Laboratories, University of Durham Durham DH1 3LE UK
    Bull Entomol Res 93:375-81. 2003
    Global warming may affect the future pattern of many arthropod-borne diseases, yet the relationship between temperature and development has been poorly described for many key vectors...
  98. ncbi Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery
    Mei Chu Lo
    Biophysics Enzymology Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA
    Anal Biochem 332:153-9. 2004
    ..monitor protein thermal unfolding, the ligand-binding affinity can be assessed from the shift of the unfolding temperature (Delta Tm) obtained in the presence of ligands relative to that obtained in the absence of ligands...
  99. ncbi Long-term region-wide declines in Caribbean corals
    Toby A Gardner
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Science 301:958-60. 2003
    ..The ability of Caribbean coral reefs to cope with future local and global environmental change may be irretrievably compromised...
  100. ncbi Fingerprints of global warming on wild animals and plants
    Terry L Root
    Center for Environmental Science and Policy, Institute for International Studies, Stanford University, Stanford, California 94305, USA
    Nature 421:57-60. 2003
    Over the past 100 years, the global average temperature has increased by approximately 0.6 degrees C and is projected to continue to rise at a rapid rate...
  101. ncbi Who is sensitive to extremes of temperature?: A case-only analysis
    Joel Schwartz
    Exposure, Epidemiology, and Risk Program Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Epidemiology 16:67-72. 2005
    Extremes of temperature are well known to be associated with excess mortality. Less is known about the characteristics of persons that put them at higher risk, particularly the role of medical conditions.

Research Grants78

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. PHILIP LEE JOHNSON; Fiscal Year: 2016
    ..wakes cycles, and our recent preclinical and clinical data linking a hyperactive orexin system to anxiety and temperature dysregulation;3) we will conduct animal studies to elucidate the mechanisms underlying orexin induction of ..
  3. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..This will be accomplished by examining growth sensitivity testing as performed previously after storage at room temperature, 4-8oC and -20oC...
  4. Jian Min Yuan; Fiscal Year: 2014
    ..blood and urine samples were collected from more than 50,000 subjects at baseline and stored in ultra-low temperature condition since their collection...
  5. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ..Using mass spectrometry we have demonstrated that Cryab binds between 50 and 75 different plasma proteins in a temperature dependent fashion, with the vast majority being acute phase proteins or members of the complement or ..
  6. John H Postlethwait; Fiscal Year: 2016
    ..vertebrates, other genes in the network determine sex, and in some species, environmental factors such as temperature or social cues can bias sex development...
  7. Intracellular Phase Diagram Creation Using a Micro-Differential Scanning Calorime
    GARY L SOLBREKKEN; Fiscal Year: 2010
    ..The operation of the [unreadable]DSC is based on the Peltier effect, which allows precise temperature control during both heating and cooling modes...
  8. Alzheimer's Disease Therapeutic
    Trevor P Castor; Fiscal Year: 2012
    ..formulations of bryostatin 1;and (2) Test stability of selected formulations under accelerated conditions of temperature and humidity, and evaluate in vitro characteristics and in vivo efficacy...
  9. Ghrelin: Behavioral, Anatomical, and Physiological Components of Obesity
    BRETT JOHN WARREN TEUBNER; Fiscal Year: 2011
    ..ghrelin will be made into brain loci with high SNS outflow to BAT/WAT + GHS-R1a colocalization and measure BAT temperature, uncoupling protein-1 (the critical factor for BAT thermogenesis) protein, and norepinephrine turnover rate (..
  10. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..or in concert to monitor and report on a variety of baby vital signs, including ECG, pulse-ox, skin temperature, motion detection, EPG, and blood pressure...
  11. Aquilur Rahman; Fiscal Year: 2014
    ..11) High drug stability at room temperature over one year with no decomposition SPECIFIC AIMS N&N proposes to develop the first of its class antiviral ..
  12. Computer/Electrical Engineering
    Theodore Raphan; Fiscal Year: 2011
    ..7. Work with the ME Core to establish humidity and temperature control in the OVAR enclosure. E. Human Locomotion Studies (Raphan/Cohen/Cho/Smouha/Olanow): 1...
  13. Nanoemulsion-based vaccine for chronic hepatitis B virus
    James R Baker; Fiscal Year: 2010
    ..In addition, the NE vaccine formulations for needle-free delivery are highly stable at room temperature enabling wide spread storage without refrigeration...
  14. Circadian Expression of Procolipase in the Liver: A Metabolic Signal
    Mark E Lowe; Fiscal Year: 2010
    ..For Aim 1, we will monitor the body temperature, body weight, activity, feeding behavior and food and water intake of wild-type, procolipase- deficient and ..
  15. Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in Hydrogel
    Sihong Wang; Fiscal Year: 2010
    ..b>Temperature is an important physical factor only second to oxygen supply in its influence on growth processes in general...
  16. Targeting thermoreceptors for therapeutic hypothermia
    Sean P Marrelli; Fiscal Year: 2012
    ..provided by applicant): Therapeutic hypothermia (TH) protocols consist of mild lowering of core body temperature (32-34[unreadable]C) and have proven effective in increasing survival and functional outcome following multiple ..
  17. CLIFFORD JAMES ROSEN; Fiscal Year: 2015
    ..characterized a spontaneous mutant mouse on a B6 background, Misty, that has non-functioning BAT, low body temperature, enhanced SNS tone, low trabecular bone mass with a small periosteal envelope...
  18. Controlled delivery of polypeptide hormone calcitonin
    Jagdish Singh; Fiscal Year: 2013
    ..We propose to study two specific aims: (1). To synthesize and characterize temperature sensitive poly (ethylene glycol) - poly (lactide-co-glycolide) - poly (ethylene glycol) (PEG-PLGA-PEG) triblock ..
  19. Climate Change and Adverse Birth Outcomes: Assessing the Vulnerability of Pregnan
    Shao Lin; Fiscal Year: 2013
    ..Extreme weather indicators defined by the 90th percentile of average summer temperature or the 10th percentile of winter temperature will be evaluated by intensity, duration, frequency, and timing...
  20. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2012
    ..g. spin probes) at room temperature using cryogenic detection with the new hybrid SQUID readout system...
  21. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2011
    ..g. spin probes) at room temperature using cryogenic detection with the new hybrid SQUID readout system...
  22. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
    ..The overall goal is to induce a non-lethal temperature elevation in tumor cells with "low" energy HIFU to induce HSPs and stimulate the immune response, while "high" ..
  23. Experimental engineering of ovarian grafting to promote angiogenesis for fertilit
    GLENN LEWIS SCHATTMAN; Fiscal Year: 2010
    ..Low temperature banking of ovarian tissue slices, and perhaps whole ovaries one day, now offers an option for these people and, ..
  24. Tick Midgut Proteins Critical for Borrelia Transmission
    Sukanya Narasimhan; Fiscal Year: 2010
    ..changes during the process of spirochete growth in the tick midgut, changes influenced perhaps by changes in temperature, pH or other as yet undefined factors in the tick midgut...
  25. The upper airway and the Sudden Infant Death Syndrome
    Donald Bartlett; Fiscal Year: 2012
    ..The laryngeal water receptors are not influenced by temperature changes in this range, but locally warming the medulla in the region of the nucleus of the solitary tract (NTS),..
  26. Developmental Origins of Phenotypic Characteristics that Predict Longevity
    Andrzej Bartke; Fiscal Year: 2012
    ..at one week, two weeks or two months of age on oxygen consumption (VO2), respiratory quotient (RQ), body temperature and expression of genes related to insulin action, fat and carbohydrate metabolism. 2...
  27. Impact of Temperature Profile on Outcome After Traumatic Brain Injury
    Lori Kennedy Madden; Fiscal Year: 2013
    ..b>Temperature management is one method to reduce secondary injury...
  28. Rodger A Liddle; Fiscal Year: 2016
    ..TRPV1 is activated by heat and protons, but it is unlikely that either high body temperature or acid directly activate TRPV1 in vivo...
  29. Age and Control of Human Skin Flow
    W Larry Kenney; Fiscal Year: 2013
    ..Because core temperature excursions during even mild heating or cooling (i.e...
  30. Sympathetic Regulation of AMPK in the control of non-shivering thermogenesis
    Jacob D Mulligan; Fiscal Year: 2012
    ..The second hypothesis is that AMPK contributes to the regulation of body weight and temperature by controlling the thermogenic potential and amount of non-shivering thermogenesis in brown adipose...
  31. Molecular Physiology of the Epitrachael Endocrine System
    Michael E Adams; Fiscal Year: 2012
    ..will be examined using cell-specific ablation, RNA gene silencing and cell-specific activation with light or temperature-activated ion channels...
  32. CYCLE REGULATION IN THE SYMBIONT SINORHIZOBIUM MELILOTI
    KATHERINE ELISABETH GIBSON; Fiscal Year: 2011
    ..to assess gene activity and protein localization as a function of cell cycle progression, we are generating a temperature-sensitive conditional allele of DNA polymerase III holoenzyme (Pol III), encoded by SmdnaE, that will allow DNA ..
  33. Jason C White; Fiscal Year: 2014
    ..We have enhanced the FDA FERN T021 methodology by developing the use of a Programmed Temperature Vaporizing (PTV) inlet for the GC-MS...
  34. Hypothermia, anesthesia and NMR metabolomics in ischemic neonatal brain slices
    Lawrence Litt; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Therapeutic hypothermia (lowering of body temperature), administered according to protocols (duration, temperature) has recently been found to improve neurological ..
  35. Imaging Strategies to Measure Brown Fat and Its Activity
    C Ronald Kahn; Fiscal Year: 2010
    ..Complementary measures of whole-body energy expenditure and temperature will be measured and correlated with findings using noninvasive imaging via PET/CT...
  36. Gary M Brittenham; Fiscal Year: 2014
    ..Project Information Component: Project Summary/Abstract This project will validate our new high-transition-temperature (high-Tc;operating at 77[unreadable]K, cooled by liquid nitrogen) superconducting magnetic susceptometer as the ..
  37. William P Fifer; Fiscal Year: 2015
    ..addition to our battery of existing measurements of respiration, heart rate, blood pressure, movement, EEG and temperature, we propose to incorporate new state of the art measures of venous return and tissue perfusion, as we believe ..
  38. Edward J Wagner; Fiscal Year: 2015
    ..goal of this proposal is to gain a better understanding of the cannabinoid regulation of appetite, core body temperature, metabolism, and the cellular mechanism(s) by which they affect the excitability of proopiomelanocortin (POMC) ..
  39. Christine Beeton; Fiscal Year: 2015
    ..chlamydia) pathogens, they suffer from several limitations: (i) they are sensitive to changes in pH and temperature;(ii) they have very short in vivo half-lives;(iii) a phosphorylated residue on ShK-186 can be dephosphorylated;(..
  40. Mesonephric Model of Podocyte Injury and Regeneration
    Weibin Zhou; Fiscal Year: 2012
    ..zebrafish and gene expression during podocyte regeneration;(3) using the established GFB assay(s) to screen for temperature-sensitive nephrotic zebrafish mutants and identify novel genetic causes of NS...
  41. Ionic Liquid Gas Sensors for Detection of Flammable Gases In Workplace
    Xiangqun Zeng; Fiscal Year: 2010
    ..g. flammable gas or vapor), air (oxygen) and a source of ignition (e.g. spark, open flame, or high temperature surface)...
  42. Oxymax System with Teadmill for Quantifying Exercise in Mice
    Neil B Ruderman; Fiscal Year: 2012
    ..These mice are characterized by diminished body fat, increased food intake and body temperature and a decreased ability to exercise...
  43. MARK DOUGLAS OKUSA; Fiscal Year: 2014
    ..We showed that IgM-ALA bind to leucocyte receptors in a highly specific manner and at body temperature does not cause leucocyte cell death despite presence of complement...
  44. Mechanism of PsrP mediated adhesion
    Carlos J Orihuela; Fiscal Year: 2013
    ..adhesin, is required for the development of lower respiratory tract disease, affects biofilm production, and is temperature and oxygen regulated...
  45. Slobodan Paessler; Fiscal Year: 2015
    ..For this, we will determine clinical parameters associated with immunization of rCandid1cSD including: body temperature and weight, overall activity, assessment of hematological and clinical pathology data covering kidney and liver ..
  46. Functional Selection of Novel Ligands from the Neuroendocrine Secretome
    David Larocca; Fiscal Year: 2010
    ..region that links the body's perception of its environment with its regulation of body functions such as temperature, blood pressure, appetite, digestion, and sleep...
  47. Terry W Snell; Fiscal Year: 2014
    ..work, we determine the effects on aging and longevity of dietary restriction, oxidative stress, and elevated temperature in five closely related strains of the Brachionus plicatilis species complex...
  48. Tb-FISH (Fluorescent in Situ Hybridization) Assay for Direct Detection of M. tube
    JYOTSNA S SHAH; Fiscal Year: 2010
    ..1. Can be performed directly on unprocessed sputum at room temperature. 2. Has specificity of amplified assays and sensitivity superior to direct acid-fast staining. 3...
  49. AREA: Rapamycin, ambient temperature, and longevity
    Steven J Swoap; Fiscal Year: 2010
    ..Swoap Title - AREA: Rapamycin, ambient temperature, and longevity in mice Until recently, additives to the diet have been unable to mimic the lifespan-extension ..
  50. Preoptic histamine signaling in thermoregulation and energy expenditure
    IUSTIN VIRGIL TABAREAN; Fiscal Year: 2012
    ..Warm- sensitive PO/AH neurons increase their firing rate in response to temperature elevation (in contrast to the temperature-insensitive neurons) and function as integrators of homeostatic ..
  51. Erin G Reed-Geaghan; Fiscal Year: 2014
    ..The cutaneous somatosensory system processes information that organisms "feel", such as pain, pressure, temperature, and touch. Detection of points, edges, and curvature is mediated by the Merkel cell neurite complex...
  52. Regulated Hypothermia to Treat Hypoxic-Ischemic Brain Injury
    Laurence M Katz; Fiscal Year: 2010
    ..Forced hypothermia is currently used clinically to lower body temperature and works by overwhelming the body's thermoregulatory mechanisms that resist cooling...
  53. Development of Site-Specific Mutagenesis in Coxiella burnetti
    JAMES EVANS SAMUEL; Fiscal Year: 2012
    ..Inactivated genes will be delivered on the stable replicating Coxiella vector with a curable, for replication temperature-sensitive origin...
  54. Mark R Opp; Fiscal Year: 2016
    ..Outcome measures for most experiments include symptoms of clinical illness (altered sleep, changes in brain temperature, reductions in water and food consumption, loss of body weight) and mortality...
  55. Indranil Biswas; Fiscal Year: 2015
    ..and efficiently to various environmental fluxes, including severe nutrient limitation, fluctuations in pH and temperature, and changes in oxidative and osmotic tensions...
  56. Neuroprotection by Mitochondria-targeted Antioxidants
    ANUMANTHA GOUNDER KANTHASAMY; Fiscal Year: 2013
    ..We will use several analytical techniques (low-temperature EPR, HPLC-fluorescence and electrochemical detection, HPLC/MS, proteomics) to detect and quantitate ROS/RNS, ..
  57. Branched-chain fatty acids and membrane function in Listeria monocytogenes
    BRIAN JAMES WILKINSON; Fiscal Year: 2012
    ..Fatty acid anteiso C15:0 increases in low-temperature grown bacteria by a combination of fatty acid shortening and branching switching from iso to anteiso fatty ..
  58. Fluorescence enhanced optical tomography
    Eva M Sevick-Muraca; Fiscal Year: 2012
    ..for CT, PET, and NIR tomography which facilitates administration of anesthesia, maintenance of animal temperature, as well as EKG and respiratory gating;(3) Integrate FDPM data acquisition software and Transpire/BCM RTE-based ..
  59. Mark J Mamula; Fiscal Year: 2016
    ..protein modification, termed isoaspartyl, can occur spontaneously under physiologic conditions of pH and temperature. While the modification has been known to exist in cells for many years now, the immunity to such modifications ..
  60. Short-term responses to temperature changes in Escherichia coli
    Christine A White Ziegler; Fiscal Year: 2010
    ..b>Temperature is one of the many signals in the environment bacteria use as a cue for regulating gene expression...
  61. Hamed Jafar-Nejad; Fiscal Year: 2016
    ..Unlike other regulators of Notch, null mutations of rumi exhibit a dramatically temperature-sensitive Notch loss-of- function phenotype...
  62. John R Perfect; Fiscal Year: 2016
    ..the virulence composite: 1) genes encoding enzymes;2) oxidative stress genes;3) signaling pathway genes;4) high temperature growth genes;5) impact of mitochondria and respiration;6) influence of attenuated null mutants on host immunity...
  63. Genetic Control of Heart Function in a Hibernating Mammal
    Matthew T Andrews; Fiscal Year: 2010
    ..The fundamental adaptation present in natural hibernators is greatly reduced body temperature, metabolism and respiration- conditions that buy precious time in cases of myocardial ischemia, traumatic ..
  64. REGULATION BY THE ESCHERICHIA COLI SMALL RNA, DSRA
    DARREN SLEDJESKI; Fiscal Year: 2002
    ..In Shigella spp. and enteroinvasive E. coli, H-NS (VirR) represses the expression of virulence genes at low temperature and low osmolarity...
  65. Temperature & Vasomotor Tone During the First 5 Days in Preterms Less than 1000g
    ROBIN BRITT KNOBEL; Fiscal Year: 2010
    ..Objective: This study will examine maturation of vasomotor tone by measuring central and peripheral body temperature of 30 extremely low birth weight (ELBW) infants in relationship to peripheral perfusion during the first 5 days ..
  66. Mechanical Stress and the Heat-Treatment of Soft Tissue
    JAY HUMPHREY; Fiscal Year: 2003
    ..Recent uniaxial studies in our lab reveal that whereas increasing temperature hastens the thermal-damage process, increased loading during heating delays it...
  67. Development of a High Efficiency Plasma Sterilizer
    BRIAN BROSDAHL; Fiscal Year: 2007
    ..provided by applicant): This research supports the development and commercialization of a more effective low temperature gas plasma sterilizer (GPS)...
  68. GLASS TRANSITION TEMPERATURE AND WEAR OF DENTAL RESINS
    JAN STANNARD; Fiscal Year: 1993
    ..The hypothesis of this proposal is that the wear of composites are related to the glass transition temperature (Tg) of the polymer(s) used in composites; specifically wear is hypothesized to be lowest when the polymer's ..
  69. Effects of Acupuncture-Induced nNOS-NO in Dorsal Medulla on Sensory Neuropathy
    Sheng Xing Ma; Fiscal Year: 2010
    ..The most common forms of diabetic neuropathies are sensory dysfunctions with hyperalgesia and reduced temperature and vibration perception thresholds, which lead to very distressing and debilitating clinical complications...
  70. NEURAL CONTROL OF TEMPERATURE REGULATION
    JACK BOULANT; Fiscal Year: 2006
    ..recordings and immunohistochemistry to study hypothalamic neuronal networks that regulate body temperature and fever...
  71. Internal Polymeric Vessel Occluder for Temporary Vascular Occlusion of the Kidney
    PETER MADRAS; Fiscal Year: 2007
    ..At low temperatures, the polymeric solution is a liquid. As the temperature increases to body temperature, the viscosity of the solution rapidly increases several orders of magnitude to ..
  72. Viral Encephalitis, Chemokines and Sleep
    LARRY D contact SANFORD; Fiscal Year: 2010
    Our goal in this project is to determine the changes in sleep, temperature and activity that occur during the acute phase response and recovery phase after inoculation with Vesicular Stomatitis Virus (VSV), a well- established animal ..
  73. ENVIRONMENTAL SEX DETERMINATION AND DIFFERENTIATION
    David Crews; Fiscal Year: 1991
    ..In some reptiles, however, the temperature at which the egg incubates determines whether the embryo hatches as a male or a female (temperature-dependent ..