radiation tolerance

Summary

Summary: The ability of some cells or tissues to withstand ionizing radiation without serious injury. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.

Top Publications

  1. ncbi The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
    Tiffany M Phillips
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095 1714, USA
    J Natl Cancer Inst 98:1777-85. 2006
  2. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
  3. ncbi Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
    Benjamin J Moeller
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 5:429-41. 2004
  4. ncbi An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
    Lyudmila G Burdelya
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Science 320:226-30. 2008
  5. pmc MicroRNAs: new players in the DNA damage response
    Hailiang Hu
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    J Mol Cell Biol 3:151-8. 2011
  6. pmc WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells
    Wendy A Woodward
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:618-23. 2007
  7. ncbi Tumor response to radiotherapy regulated by endothelial cell apoptosis
    Monica Garcia-Barros
    Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Science 300:1155-9. 2003
  8. pmc Notch promotes radioresistance of glioma stem cells
    Jialiang Wang
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Stem Cells 28:17-28. 2010
  9. ncbi Role of cell cycle in mediating sensitivity to radiotherapy
    Timothy M Pawlik
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Box 66, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 59:928-42. 2004
  10. ncbi Exploring the role of cancer stem cells in radioresistance
    Michael Baumann
    Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology, and Michael Baumann is also at the University Cancer Center, Technische Universitat Dresden, 01307 Dresden, Germany
    Nat Rev Cancer 8:545-54. 2008

Detail Information

Publications314 found, 100 shown here

  1. ncbi The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
    Tiffany M Phillips
    Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095 1714, USA
    J Natl Cancer Inst 98:1777-85. 2006
    ..Cancer-initiating cells can now be prospectively isolated from breast cancer cell lines and tumor samples and propagated as mammospheres in vitro under serum-free conditions...
  2. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
    ..Targeting DNA damage checkpoint response in cancer stem cells may overcome this radioresistance and provide a therapeutic model for malignant brain cancers...
  3. ncbi Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
    Benjamin J Moeller
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 5:429-41. 2004
    ..These data describe novel pathways contributing significantly to our understanding of HIF-1 regulation which may be major determinants of tumor radiosensitivity, potentially having high clinical relevance...
  4. ncbi An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
    Lyudmila G Burdelya
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Science 320:226-30. 2008
    ..CBLB502 also showed radioprotective activity in lethally irradiated rhesus monkeys. Thus, TLR5 agonists could potentially improve the therapeutic index of cancer radiotherapy and serve as biological protectants in radiation emergencies...
  5. pmc MicroRNAs: new players in the DNA damage response
    Hailiang Hu
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    J Mol Cell Biol 3:151-8. 2011
    ....
  6. pmc WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells
    Wendy A Woodward
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:618-23. 2007
    ..These data demonstrate that, compared with differentiated cells, progenitor cells have different cell survival properties that may facilitate the development of targeted antiprogenitor cell therapies...
  7. ncbi Tumor response to radiotherapy regulated by endothelial cell apoptosis
    Monica Garcia-Barros
    Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Science 300:1155-9. 2003
    ..These studies indicate that microvascular damage regulates tumor cell response to radiation at the clinically relevant dose range...
  8. pmc Notch promotes radioresistance of glioma stem cells
    Jialiang Wang
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Stem Cells 28:17-28. 2010
    ..Taken together, our results suggest a critical role of Notch signaling to regulate radioresistance of glioma stem cells. Inhibition of Notch signaling holds promise to improve the efficiency of current radiotherapy in glioma treatment...
  9. ncbi Role of cell cycle in mediating sensitivity to radiotherapy
    Timothy M Pawlik
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Box 66, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 59:928-42. 2004
    ..We describe how cell cycle and DNA damage checkpoint control relates to exposure to ionizing radiation...
  10. ncbi Exploring the role of cancer stem cells in radioresistance
    Michael Baumann
    Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology, and Michael Baumann is also at the University Cancer Center, Technische Universitat Dresden, 01307 Dresden, Germany
    Nat Rev Cancer 8:545-54. 2008
    ....
  11. ncbi Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras
    Jee Sun Oh
    Medical Science Research Institute, Seoul National University Bundang Hospital, Seongnamsi, Korea
    Int J Radiat Oncol Biol Phys 76:5-8. 2010
    ..To evaluate the potential of targeting Lin28-let7 microRNA regulatory network for overcoming the radioresistance of cancer cells having activated K-Ras signaling...
  12. ncbi A single ataxia telangiectasia gene with a product similar to PI-3 kinase
    K Savitsky
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel
    Science 268:1749-53. 1995
    ..The discovery of ATM should enhance understanding of AT and related syndromes and may allow the identification of AT heterozygotes, who are at increased risk of cancer...
  13. ncbi MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy
    Joanne B Weidhaas
    Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, P O Box 208040, New Haven, CT 06520, USA
    Cancer Res 67:11111-6. 2007
    ..These findings are the first direct evidence that miRNAs can suppress resistance to anticancer cytotoxic therapy, a common feature of cancer cells, and suggest that miRNAs may be a viable tool to augment current cancer therapies...
  14. ncbi The role of p53 in determining sensitivity to radiotherapy
    Andrei V Gudkov
    Department of Molecular Biology, NC20, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Rev Cancer 3:117-29. 2003
    ..One of the key molecules involved in a cell's response to IR is p53. Understanding these mechanisms indicates new rational approaches to improving cancer treatment by IR...
  15. ncbi Accumulation of Mn(II) in Deinococcus radiodurans facilitates gamma-radiation resistance
    M J Daly
    Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Science 306:1025-8. 2004
    ..In contrast, Shewanella oneidensis and Pseudomonas putida have high iron but low intracellular manganese concentrations and are very sensitive. We propose that Mn(II) accumulation facilitates recovery from radiation injury...
  16. ncbi Low-dose hyper-radiosensitivity: a consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells
    B Marples
    Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201 2013, USA
    Radiat Res 161:247-55. 2004
    ..The putative role of known damage response factors such as ATM, PARP, H2AX, 53BP1 and HDAC4 is also included within the framework of the HRS model...
  17. pmc Oxidative stress resistance in Deinococcus radiodurans
    Dea Slade
    Université de Paris Descartes, Faculte de Medecine, INSERM U1001, 156 rue de Vaugirard, 75015 Paris, France
    Microbiol Mol Biol Rev 75:133-91. 2011
    ..The study of the antioxidation protection in D. radiodurans is therefore of considerable potential interest for medicine and public health...
  18. pmc p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
    Irene M Ward
    Department of Oncology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Mol Cell Biol 23:2556-63. 2003
    ..These data indicate that 53BP1 acts downstream of ATM and upstream of Chk2 in the DNA damage response pathway and is involved in tumor suppression...
  19. pmc Radiation modulation of microRNA in prostate cancer cell lines
    Sajni Josson
    Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
    Prostate 68:1599-606. 2008
    ..MicroRNAs (miRNA) are gene regulators and play an important role in response to cellular stress...
  20. ncbi A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity
    Martin Kühne
    Fachrichtung Biophysik, Universitat des Saarlandes, Homburg Saar, Germany
    Cancer Res 64:500-8. 2004
    ..These data argue that the DSB repair defect underlies a significant component of the radiosensitivity of AT cells...
  21. pmc Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy
    H Harada
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Sakyo ku, Japan
    Br J Cancer 100:747-57. 2009
    ....
  22. ncbi BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery
    Sabrina Facchino
    Developmental Biology Laboratory, Maisonneuve Rosemont Hospital, Montreal, Quebec, Canada
    J Neurosci 30:10096-111. 2010
    ..BMI1 thus displays a previously uncharacterized function in controlling DNA DSB response and repair. Pharmacological inhibition of BMI1 combined with radiation therapy may provide an effective mean to target GBM stem cells...
  23. pmc The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells
    M Kato
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Oncogene 28:2419-24. 2009
    ....
  24. pmc MicroRNA-148b enhances the radiosensitivity of non-Hodgkin's Lymphoma cells by promoting radiation-induced apoptosis
    Yong Wu
    Department of Hematology, Guangzhou First Municipal People s Hospital Affiliated to Guangzhou Medical College, 1 Panfu Road, Guangzhou, People s Republic of China
    J Radiat Res 53:516-25. 2012
    ....
  25. ncbi Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: the risk factors and hepatic radiation tolerance
    Shi xiong Liang
    Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai, China
    Int J Radiat Oncol Biol Phys 65:426-34. 2006
    ..To identify risk factors relevant to radiation-induced liver disease (RILD) and to determine the hepatic tolerance to radiation...
  26. pmc Down-regulation of survivin expression by small interfering RNA induces pancreatic cancer cell apoptosis and enhances its radiosensitivity
    Hai Tao Guan
    Department of Oncosurgery, the Second Affiliated Hospital of Xi an Jiaotong University Medical College, 157 West 5th Road, Xi an 710004, Shaanxi Province, China
    World J Gastroenterol 12:2901-7. 2006
    ..To investigate the inhibitory effect of small interfering RNA (siRNA) on the expression of survivin in pancreatic cancer cell line PC-2 and the role of siRNA in inducing PC-2 cell apoptosis and enhancing its radiosensitivity...
  27. ncbi microRNA-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling
    Kyung Min Lee
    Medical Research Institute, Seoul National University Bundang Hospital, Republic of Korea
    Radiother Oncol 101:171-6. 2011
    ..miR-7 may be a useful therapeutic target for overcoming the radio-resistance of human cancers with activated EGFR-PI3K-AKT signaling...
  28. ncbi Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity
    Remko Prevo
    Radiobiology Research Institute, Oxford University, Oxford, United Kingdom
    Cancer Res 68:5915-23. 2008
    ..These results indicate that pharmacologic inhibitors with enhanced specificity for class I PI3K may be of benefit when combined with radiotherapy...
  29. ncbi PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation
    R Deng
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Oncogene 30:944-55. 2011
    ..These results together support Akt can upregulate the expression of Mre11 through GSK3β/ β-catenin/LEF pathway to elevate DSB-repair capacity in cancer cells...
  30. ncbi Low-dose hypersensitivity: current status and possible mechanisms
    M C Joiner
    Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK
    Int J Radiat Oncol Biol Phys 49:379-89. 2001
    ..In this paper, we propose possible mechanisms to explain this phenomenon based on our data accumulated over the last decade and a review of the literature...
  31. ncbi Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment
    Benjamin J Moeller
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    Cancer Metastasis Rev 26:241-8. 2007
    ..HIF-1 and/or its target genes may represent therapeutic targets which could be manipulated to influence hypoxia's impact on tumor radiosensitivity...
  32. pmc Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation
    S Vispe
    Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, UPR 9062, 205 route de Narbonne, 31077 Toulouse Cedex, France
    Nucleic Acids Res 26:2859-64. 1998
    ..This suggests that Rad51 participate in the repair of double-strand breaks most likely by homologous recombination involving sister chromatids formed after the S phase...
  33. ncbi DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency
    M O'Driscoll
    Genome Damage and Stability Unit, University of Sussex, Brighton, East Sussex, BN1 9RR, United Kingdom
    Mol Cell 8:1175-85. 2001
    ..An unexpected V(D)J recombination phenotype is observed involving a small decrease in rejoining frequency coupled with elevated imprecision at signal junctions...
  34. ncbi Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient
    E Riballo
    MRC Cell Mutation Unit, University of Sussex, Brighton, BN1 9RR, UK
    Curr Biol 9:699-702. 1999
    ..The defect, however, may confer a predisposition to leukaemia...
  35. ncbi The role of p53 in chemosensitivity and radiosensitivity
    Wafik S El-Deiry
    Department of Medicine Hematology Oncology, Abramson Cancer Center, University of Pennsylvania School of Medicine, 415 Curie Boulevard, CRB 437A, Philadelphia, PA 19104, USA
    Oncogene 22:7486-95. 2003
    ....
  36. pmc Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice
    Xiaoping Cui
    College of Veterinary Medicine and Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, 48824, USA
    Mol Cell Biol 25:10842-52. 2005
    ..We conclude that separate DNA-PK autophosphorylation events may function reciprocally by not only regulating DNA end processing but also affecting DSB repair pathway choice...
  37. ncbi Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells
    Rashi Iyer
    Bioscience Division, MS 888, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Mutat Res 503:1-9. 2002
    ....
  38. ncbi Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature
    Emmanouil Fokas
    Gray Institute for Radiation Oncology and Biology, Oxford University, Oxford, United Kingdom
    Cancer Res 72:239-48. 2012
    ..The substantial therapeutic gain observed after combination of NVP-BEZ235 with irradiation has conceptual implications for cancer therapy and could be of broad translational importance...
  39. pmc Combined Bcl-2/mammalian target of rapamycin inhibition leads to enhanced radiosensitization via induction of apoptosis and autophagy in non-small cell lung tumor xenograft model
    Kwang Woon Kim
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5671, USA
    Clin Cancer Res 15:6096-105. 2009
    ..Radiotherapy has a central role in the treatment of non-small cell lung cancer. Effectiveness of this modality, however, is often limited as resistance results from defects in cell death...
  40. ncbi Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma
    James A Bonner
    Department of Radiation Oncology, The University of Alabama at Birmingham, AL 35233, USA
    Radiother Oncol 92:339-44. 2009
    ..Studies were performed to determine if inhibition of this downstream protein produces radiosensitization...
  41. pmc Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction
    L Stingl
    Klinik für Strahlentherapie der Universität Würzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Br J Cancer 102:1578-91. 2010
    ..The techniques used included cell and colony counts, expression of Hsp90, Hsp70, Akt, survivin, cleaved caspase 3, p53, cell-cycle progression and associated proteins. DNA damage was analysed by histone gammaH2AX and Comet assays...
  42. ncbi Hypersensitivity to very-low single radiation doses: its relationship to the adaptive response and induced radioresistance
    M C Joiner
    Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK
    Mutat Res 358:171-83. 1996
    ....
  43. ncbi Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
    Benjamin J Moeller
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Cell 8:99-110. 2005
    ..These data provide a strong rationale for pursuing sequence-specific combinations of HIF-1 blockade and conventional therapeutics...
  44. ncbi Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines
    Judit P Banath
    British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
    Cancer Res 64:7144-9. 2004
    ..The possibility that the presence of gammaH2AX foci may not always signify the presence of a physical break, notably in some tumor cell lines, is also supported by these results...
  45. ncbi Engaging the vascular component of the tumor response
    Zvi Fuks
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Cancer Cell 8:89-91. 2005
    ..HIF-1 thus serves as a legitimate target for differential modulation of tissue response to radiation...
  46. ncbi DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
    K M Frank
    Howard Hughes Medical Institute, Boston, Massachusetts, USA
    Mol Cell 5:993-1002. 2000
    ....
  47. pmc Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
    M Takata
    Department of Molecular Immunology and Allergology, Kyoto University Medical School, Konoe Yoshida, Sakyo ku, Kyoto 606 8315, Japan
    EMBO J 17:5497-508. 1998
    ..These observations provide the first genetic evidence that both repair pathways play a role in maintaining chromosomal DNA during the cell cycle...
  48. ncbi Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    D M Aebersold
    Department of Radiation Oncology, University of Bern, Switzerland
    Cancer Res 61:2911-6. 2001
    ....
  49. ncbi RBE for carbon track-segment irradiation in cell lines of differing repair capacity
    W K Weyrather
    Gesellschaft fur Schwerionenforschung, Darmstadt, Germany
    Int J Radiat Biol 75:1357-64. 1999
    ..RBE values for cell inactivation at different survival levels were determined and the differences in the RBE-LET patterns were compared with the individual sensitivity to photon irradiation of the different cell lines...
  50. pmc HIF-1 and tumour radiosensitivity
    B J Moeller
    Department of Radiation Oncology, Duke University Medical Center, MSRB, Research Drive, Durham, NC 27710, UK
    Br J Cancer 95:1-5. 2006
    ..Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might optimise tumour radiosensitivity...
  51. ncbi DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing
    Claudia E Rübe
    Department of Radiation Oncology, Saarland University, Homburg Saar, Germany
    Clin Cancer Res 14:6546-55. 2008
    ..Using a preclinical mouse model, the highly sensitive gammaH2AX-foci approach was tested to verify even subtle, genetically determined DSB repair deficiencies known to be associated with increased normal tissue radiosensitivity...
  52. ncbi Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction
    Anjali K Gupta
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6072, USA
    Clin Cancer Res 8:885-92. 2002
    ..We have shown previously that radioresistance could be conferred via the Ras-PI3K pathway. Here we investigate the contribution of EGFR to this pathway and its impact on treatment outcome...
  53. pmc Targeting inflammatory pathways for tumor radiosensitization
    Amit Deorukhkar
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Biochem Pharmacol 80:1904-14. 2010
    ..We review recent data demonstrating the pivotal role played by inflammatory pathways in cancer progression and modulation of radiation response...
  54. ncbi Expression and function of miRNA in postoperative radiotherapy sensitive and resistant patients of non-small cell lung cancer
    Xiao Chun Wang
    Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science, Tianjin 300192, China
    Lung Cancer 72:92-9. 2011
    ..To investigate the different miRNA expression profiles of postoperative radiotherapy sensitive and resistant patients of non-small cell lung cancer, explore their potential role and find some radio-sensitivity markers...
  55. pmc Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells
    Hui Fang Li
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC, USA
    Radiat Oncol 4:43. 2009
    ..IR has been shown to induce PI3K-Akt activation in many cell types, and activation of the PI3K-Akt signaling pathway has been correlated with radioresistance...
  56. ncbi Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy
    Neelam Taneja
    Center for Molecular Oncology, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA
    J Biol Chem 279:2273-80. 2004
    ..These results suggest that H2AX is a potential molecular target to enhance the effects of radiotherapy...
  57. ncbi HIF-1 and NDRG2 contribute to hypoxia-induced radioresistance of cervical cancer Hela cells
    Junye Liu
    Department of Radiation Medicine, Fourth Military Medical University, Xi an, China
    Exp Cell Res 316:1985-93. 2010
    ..It would be meaningful to further explore the clinical application potential of HIF-1 and NDRG2 blockade as radiosensitizer for tumor therapy...
  58. ncbi Protein oxidation: key to bacterial desiccation resistance?
    James K Fredrickson
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    ISME J 2:393-403. 2008
    ..We present the case that survival of bacteria that inhabit dry-climate soils are highly dependent on mechanisms, which limit protein oxidation during dehydration...
  59. ncbi Control of the G2/M checkpoints after exposure to low doses of ionising radiation: implications for hyper-radiosensitivity
    Marie Fernet
    Institut Curie, Centre de Recherche, Bâtiment 110 112, Centre Universitaire, Orsay, France
    DNA Repair (Amst) 9:48-57. 2010
    ....
  60. ncbi Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation
    T Blunt
    Wellcome Cancer Research Campaign Institute, Cambridge University, England
    Cell 80:813-23. 1995
    ..As DNA-PK binds to DNA ends and is activated by these structures, our findings provide novel insights into V(D)J recombination and DNA repair processes...
  61. ncbi MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2
    Gong Chen
    Departments of 1Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, PR China
    Oncol Rep 23:997-1003. 2010
    ..These data suggest that radiation can affect miRNA expression, which regulates the cellular response, and miR-181a could be a target for enhancing the effect of radiation treatment on malignant glioma cells...
  62. ncbi Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes
    Igor Pogribny
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Biochem Biophys Res Commun 320:1253-61. 2004
    ..Based on the correlation between the levels of DNA methylation and DNA damage we propose that radiation-induced global genome DNA hypomethylation is DNA repair-related...
  63. ncbi Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities: survivin as a radioresistance factor
    Claus Rodel
    Department of Radiation Oncology, University of Erlangen, Erlangen, Germany
    Int J Radiat Oncol Biol Phys 55:1341-7. 2003
    ..We investigated the impact of survivin expression on tumor cell apoptosis in three colorectal cell lines of different intrinsic radiosensitivities...
  64. pmc Akt signaling pathway: a target for radiosensitizing human malignant glioma
    Emmanuel Chautard
    Centre Jean Perrin, Laboratoire de Radio Oncologie Expérimentale, EA 3846 Thérapie Ciblée Combinatoire en Onco Hématologie, Universite d Auvergne, Clermont Ferrand, France
    Neuro Oncol 12:434-43. 2010
    ..These data indicate that the Akt intercept node could be a more relevant therapeutic target than STAT3 for radiosensitizing human malignant glioma...
  65. pmc Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin
    Christina Bauerschmidt
    Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford OX3 7DQ, UK
    Nucleic Acids Res 38:477-87. 2010
    ..Our results suggest that the cohesin complex contributes to cell survival by promoting the repair of radiation-induced DNA double-strand breaks in G2-phase cells in an ATM-dependent pathway...
  66. ncbi The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage
    Grant S Stewart
    Cancer Research UK, Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, UK
    Cell 136:420-34. 2009
    ..These RNF168-dependent chromatin modifications orchestrate the accumulation of 53BP1 and BRCA1 to DNA lesions, and their loss is the likely cause of the cellular and developmental phenotypes associated with RIDDLE syndrome...
  67. pmc Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4
    Pei Yu Wu
    CNRS, IPBS Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    Mol Cell Biol 29:3163-72. 2009
    ..Together our findings provide unanticipated insight for understanding the physical and functional architecture of the nonhomologous end-joining ligation complex...
  68. ncbi Cell adhesion-mediated radioresistance (CAM-RR). Extracellular matrix-dependent improvement of cell survival in human tumor and normal cells in vitro
    Nils Cordes
    Institute of Radiology, Medical Academy of German Armed Forces, Munich, Germany
    Strahlenther Onkol 179:337-44. 2003
    ....
  69. pmc The deinococcal DdrB protein is involved in an early step of DNA double strand break repair and in plasmid transformation through its single-strand annealing activity
    Claire Bouthier de La Tour
    Univ Paris Sud 11, CNRS UMR 8621, LRC CEA 42V, Institut de Genetique et Microbiologie, Batiment 409, Universite Paris Sud, 91405 Orsay, France
    DNA Repair (Amst) 10:1223-31. 2011
    ....
  70. ncbi Radiation-induced adaptive responses and bystander effects
    Hideki Matsumoto
    Department of Experimental Radiology and Health Physics, Faculty of Medical Science, University of Fukui, Matsuoka, Fukui, Japan
    Biol Sci Space 18:247-54. 2004
    ..This review focuses on the radiation-induced bystander effect and the adaptive response, provides a description of the two phenomena, and discusses the contribution of the former to the latter...
  71. ncbi Can risk of radiotherapy-induced normal tissue complications be predicted from genetic profiles?
    Christian Nicolaj Andreassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Acta Oncol 44:801-15. 2005
    ..However, to fully exploit these new possibilities well-planed large-scale clinical studies are mandatory. Currently, international initiatives are taken to establish the bio banks and databases needed for this task...
  72. ncbi Low-dose radiation therapy of cancer: role of immune enhancement
    Abdullah Farooque
    Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Road, Delhi 110 0054, India
    Expert Rev Anticancer Ther 11:791-802. 2011
    ..This article focuses on the immunostimulatory effects of LDR in in vivo models and its clinical efficacy, supporting the use of LDR regimens (alone or as adjuvant) as an anticancer treatment...
  73. ncbi Differential roles of miR-199a-5p in radiation-induced autophagy in breast cancer cells
    Heqing Yi
    Key Laboratory of Radiobiology Ministry of Health, School of Public Health, Jilin University, Changchun 130021, China
    FEBS Lett 587:436-43. 2013
    ..Furthermore, we show that miR-199a-5p sensitizes MDA-MB-231 cells to irradiation. Therefore, our data identify miR-199a-5p as a novel and unique regulator of autophagy, which plays an important role in cancer biology and cancer therapy...
  74. pmc MiR-34a in age and tissue related radio-sensitivity and serum miR-34a as a novel indicator of radiation injury
    Cong Liu
    Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, PR China
    Int J Biol Sci 7:221-33. 2011
    ..Taken together, this data strongly suggests that miR-34a may be a novel indicator, mediator and target of radiation injury, radio-sensitivity and radioprotection...
  75. pmc Are cancer stem cells radioresistant?
    Walter N Hittelman
    Department of Experimental Therapeutics 019, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Future Oncol 6:1563-76. 2010
    ..This article describes potential sensitization approaches based on the dynamics and changing properties of cancer stem-like cells during therapy...
  76. ncbi Genes required for ionizing radiation resistance in yeast
    C B Bennett
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Nat Genet 29:426-34. 2001
    ..Over 50% share homology with human genes, including 17 implicated in cancer, indicating that a large set of newly identified human genes may have related roles in the toleration of radiation damage...
  77. ncbi Melatonin protects rat liver against irradiation-induced oxidative injury
    Mehmet Koc
    Radiation Oncology, Ataturk University Medical School, Turkey
    J Radiat Res 44:211-5. 2003
    ..The data obtained in this study suggest that melatonin administration prior to irradiation may prevent liver damage by irradiation...
  78. pmc Modulating the tumor microenvironment to increase radiation responsiveness
    Jayashree Karar
    Department of Radiation Oncology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
    Cancer Biol Ther 8:1994-2001. 2009
    ..The challenge remains to obtain clinical data from patients showing that modulation of the TME is an important mechanism by which biological agents can radiosensitize tumors and then to utilize this information to optimize therapy...
  79. ncbi Raf kinase inhibitor protein correlates with sensitivity of nasopharyngeal carcinoma to radiotherapy
    Lin Ruan
    Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
    J Cell Biochem 110:975-81. 2010
    ..The data suggested that RKIP was a potential biomarker for the radiosensitivity and prognosis of NPC, and its dysregulation might play an important role in the radioresistance of NPC...
  80. pmc Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage
    Angela E Zolner
    Department of Biochemistry and Molecular Biology, Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Nucleic Acids Res 39:9224-37. 2011
    ..Together, our results reveal that IR-induced phosphorylation of PNKP by ATM and DNA-PK regulates PNKP function at DSBs...
  81. ncbi Relationship between radiosensitivity and Nrf2 target gene expression in human hematopoietic stem cells
    Kengo Kato
    Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences, 66 1 Hon cho, Hirosaki, Aomori 036 8564, Japan
    Radiat Res 174:177-84. 2010
    ..The present results suggest that the antioxidant system associated with Nrf2 is involved in the radiosensitivity of HSCs...
  82. ncbi Chloride intracellular channel 1 identified using proteomic analysis plays an important role in the radiosensitivity of HEp-2 cells via reactive oxygen species production
    Jae Sung Kim
    Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    Proteomics 10:2589-604. 2010
    ....
  83. ncbi Depletion of securin induces senescence after irradiation and enhances radiosensitivity in human cancer cells regardless of functional p53 expression
    Wen Shu Chen
    Department of Life Science, Tzu Chi University, Hualien, Taiwan
    Int J Radiat Oncol Biol Phys 77:566-74. 2010
    ..The development of new strategies to trigger cancer cell death besides apoptosis is necessary. This study investigated the role of securin in radiation-induced apoptosis and senescence in human cancer cells...
  84. ncbi Sorafenib and radiation: a promising combination in colorectal cancer
    Andrew W Suen
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI, USA
    Int J Radiat Oncol Biol Phys 78:213-20. 2010
    ..To examine the combination of radiation and the multikinase inhibitor sorafenib in human colorectal cancer cell lines and xenografts...
  85. ncbi Variability in tolerance to UV-B radiation among Beauveria spp. isolates
    Everton K K Fernandes
    Department of Biology, Utah State University, Logan, UT 84322 5305, USA
    J Invertebr Pathol 96:237-43. 2007
    ..The identification in this study of several B. bassiana isolates with relatively high UV-B tolerance will guide the selection of isolates for future arthropod microbial control experiments...
  86. ncbi Altered fractionation in radiotherapy: from radiobiological rationale to therapeutic gain
    Loredana G Marcu
    University of Oradea, Faculty of Science, Romania
    Cancer Treat Rev 36:606-14. 2010
    ....
  87. pmc Microenvironmental regulation of glioblastoma radioresponse
    Muhammad Jamal
    Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida 33612, USA
    Clin Cancer Res 16:6049-59. 2010
    ..Therefore, to determine whether the brain microenvironment affects the intrinsic radiosensitivity of GBM cells, we compared the radioresponse of GBM TSCs grown in vitro and as brain tumor xenografts...
  88. ncbi Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma
    Amit K Das
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Res 67:5267-74. 2007
    ....
  89. pmc SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation
    Yong Xu
    Department of Radiation Medicine, University of Kentucky, College of Medicine, Lexington, KY 40536, USA
    Mol Cancer Ther 7:2367-76. 2008
    ....
  90. ncbi Hyperthermic radiosensitization: mode of action and clinical relevance
    H H Kampinga
    Department of Radiation and Stress Cell Biology, University of Groningen, The Netherlands
    Int J Radiat Biol 77:399-408. 2001
    ..To provide an update on the recent knowledge about the molecular mechanisms of thermal radiosensitization and its possible relevance to thermoradiotherapy...
  91. ncbi Single nucleotide polymorphisms of DNA repair genes as predictors of radioresponse
    Matthew B Parliament
    Department of Radiation, Cross Cancer Institute, Edmonton, Alberta, Canada
    Semin Radiat Oncol 20:232-40. 2010
    ....
  92. ncbi Human augmenter of liver regeneration is important for hepatoma cell viability and resistance to radiation-induced oxidative stress
    Yan Cao
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Free Radic Biol Med 47:1057-66. 2009
    ..Targeting hALR may be a promising novel approach to enhance the radiosensitivity of hepatoma cancers...
  93. ncbi Caveolin-1 mediated radioresistance of 3D grown pancreatic cancer cells
    Stephanie Hehlgans
    OncoRay Center for Radiation Research in Oncology, Dresden University of Technology, Dresden, Germany
    Radiother Oncol 92:362-70. 2009
    ..Resistance of pancreatic ductal adenocarcinoma (PDAC) to chemo- and radiotherapy is a major obstacle. The integral membrane protein Caveolin-1 (Cav-1) has been suggested as a potent target in human pancreatic carcinoma cells...
  94. ncbi E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells
    Jan Theys
    Department of Radiation Oncology Maastro Lab, Maastricht University Medical Centre, The Netherlands
    Radiother Oncol 99:392-7. 2011
    ..Intratumoral hypoxia has been linked to EMT induction. We hypothesized that signals from the tumor microenvironment such as growth factors and tumor oxygenation collaborate to promote EMT and thereby contribute to radioresistance...
  95. pmc Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90
    Fiona A Dungey
    Genome Damage and Stability Centre, University of Sussex, Falmer BN1 9RQ, United Kingdom
    Mol Cancer Ther 8:2243-54. 2009
    ..17-AAG is therefore a tumor-specific, replication-dependent radiosensitizer that enhances the effects of PARP inhibition. This combination has therapeutic potential in the management of GBM...
  96. ncbi Radiosensitizing effects of gefitinib at different administration times in vitro
    Hong Qing Zhuang
    Department of Radiotherapy, Tianjin Cancer Institute and Hospital, Tianjin Lung Cancer Center, and Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
    Cancer Sci 100:1520-5. 2009
    ..Moreover, the pro-apoptotic/antiapoptotic and DNA repair factors may be important modulators taking part in the molecular events of the radiosensitizing effect of gefitinib combined with irradiation...
  97. ncbi Use of γH2AX and other biomarkers of double-strand breaks during radiotherapy
    Ali Sak
    Department of Radiotherapy, University Hospital Essen, Essen, Germany
    Semin Radiat Oncol 20:223-31. 2010
    ..Validation by prospective studies is needed...
  98. ncbi Identification of differentially expressed genes contributing to radioresistance in lung cancer cells using microarray analysis
    Wan feng Guo
    Beijing Institute of Radiation Medicine, Beijing 100850, China
    Radiat Res 164:27-35. 2005
    ..This list of genes may be useful in attempts to sensitize the radioresistant lung cancer cells...
  99. ncbi Epidermal growth factor receptor and tumor response to radiation: in vivo preclinical studies
    Luka Milas
    Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 58:966-71. 2004
    ..In this article, we review preclinical studies, primarily from our laboratory, addressing the role of EGFR in tumor radioresponse and the use of C225, a human-mouse chimeric anti-EGFR monoclonal antibody, to improve the results of RT...
  100. ncbi Radiation-induced mitotic catastrophe in PARG-deficient cells
    Jean Christophe Ame
    IREBS FRE3211 du CNRS, Universite de Strasbourg, ESBS, Bd Sébastien Brant, BP 10413, 67412 Illkirch Cedex, France
    J Cell Sci 122:1990-2002. 2009
    ..Our results suggest that PARG could be a novel potential therapeutic target for radiotherapy...
  101. ncbi Induction of autophagic cell death and radiosensitization by the pharmacological inhibition of nuclear factor-kappa B activation in human glioma cell lines
    Yoshifumi Tsuboi
    Departments of Neurosurgery, Faculty of Medicine, University of Toyama, Sugitani, Toyama, Japan
    J Neurosurg 110:594-604. 2009
    ..In the present study, the authors analyzed the effect of pitavastatin as a potential inhibitor of NF-kappaB activation on the radiosensitivity of A172, U87, and U251 human glioma cell lines...

Research Grants63

  1. 14th International Workshop on Ataxia-Telangiectasia and ATM
    Richard A Gatti; Fiscal Year: 2010
    ..We also hope to encourage new young investigators to develop an interest in both clinical and basic A-T/ATM-related research. ..
  2. Regulation of non-histone protein functions by histone deacetylases
    Edward Seto; Fiscal Year: 2010
    ..Description of changes: The objectives and hypotheses of this revised proposal remain unchanged. As a result, there are minimal changes in this revised abstract section. ..
  3. HPV, Tumor Metabolism and Radiosensitivity in Head and Neck Cancer
    Hyeong Reh Choi Kim; Fiscal Year: 2013
    ..Completion of this exploratory R21 application will help us understand molecular basis for HPV-associated radiosensitivity and provide important information for further patient stratification and the design of biomarker-driven therapy. ..
  4. Rel B mediated-redox regulation of radiation therapy
    William H St Clair; Fiscal Year: 2013
    ..Thus, this study will enable physicians to tailor risk-adjusted strategies for treatment of prostate cancer. ..
  5. Long-acting growth factors for treating the acute and long term effects of lethal
    Christie M Orschell; Fiscal Year: 2013
    ....
  6. 15th International Workshop on Ataxia-Telangiectasia and ATM to be held in India
    Tej K Pandita; Fiscal Year: 2012
    ..This will be the first A-T Workshop that provides a forum to discuss the near term potential for applying the results from basic ATM studies to possible A-T clinical treatment trials and, in the future, other neurological diseases. ..
  7. Investigation of a Novel Role for RNA Binding Proteins in DNA Repair
    William S Dynan; Fiscal Year: 2013
    ....
  8. Development of Small Molecule Radiation Sensitizers
    SEKHAR RAJA KONJETI; Fiscal Year: 2013
    ..The short term goal of this application is to valid this hypothesis. The long term goal is to develop these small molecule inhibitors into a radiation sensitizer that exhibits clinical efficacy. ..
  9. EXTENSION OF RADIOTHERAPY RESEARCH
    Raymond E Meyn; Fiscal Year: 2013
    ..When encouraging, results will serve as the basis for formulating compelling regimen for clinical testing. ..
  10. Impact of Genomics on Disparities in Breast Cancer Radiosensitivity
    Jennifer J Hu; Fiscal Year: 2013
    ..abstract_text> ..
  11. Targeting SYK Tyrosine Kinase to Overcome Radiation Resistance in ALL
    Fatih M Uckun; Fiscal Year: 2013
    ..The successful completion of this research project may provide the foundation for therapeutic innovation against childhood leukemia. ..
  12. The 26S Proteasome in Cancer Stem Cells
    Frank Pajonk; Fiscal Year: 2013
    ....
  13. Identification of radiation sensitivity alleles by whole exome sequencing
    Patrick Concannon; Fiscal Year: 2012
    ....
  14. Translational Control of Radiation-Induced Apoptosis
    Alexey G Ryazanov; Fiscal Year: 2012
    ..This research will be done in collaboration with the Institute of Protein Research, Russian Academy of Sciences, Puschino, Russia, in collaboration with professor A. S. Spirin as an extension of NIH grant No. RC1 AI078513. ..
  15. Isolation of Genes for Radiation Sensitivity
    Patrick Concannon; Fiscal Year: 2010
    ....
  16. Regulation of the DNA damage response by ATM-MRN pathway
    Jean Gautier; Fiscal Year: 2013
    ..Finally, in the fourth aim, we will validate and initiate the characterization of novel components of the DSB proteome identified in our studies. ..
  17. Cdk-2 Independent role of cyclin E in Cell survival
    Alexandru Almasan; Fiscal Year: 2013
    ..abstract_text> ..
  18. Regulation of NEMO modifications in radiation-induced NF-kB signaling
    Shigeki Miyamoto; Fiscal Year: 2013
    ..Second, understanding the mechanisms of NF-kB activation by DNA damaging agents may help identify novel drug targets to improve the current methods of cancer therapy. ..
  19. SPORE: Targeted Therapies for Glioma
    Tracy T Batchelor; Fiscal Year: 2013
    ..abstract_text> ..
  20. Development of New Drugs that Protect Gastrointestinal Tract from Radiation
    ALEXEY RYAZANOV; Fiscal Year: 2009
    ..2. To identify specific inhibitors of eEF2 kinase and to develop lead compounds that can be used to develop drugs that protect gastrointestinal tract from radiation damage. ..
  21. IN SITU ANTI-TUMOR IMMUNITY AND EFFECTS OF RADIATION
    Edith M Lord; Fiscal Year: 2013
    ..The information obtained will provide insight into the interplay between malignant cells and cells of the immune system both before and after radiation therapy, information essential for effective combination of these modalities. ..
  22. X-irradiator for in vivo and in vitro studies with relevance to basic stress sign
    Albert J Fornace; Fiscal Year: 2010
    ..Due to NRC security requirements for gamma irradiators, the manufacturer, model number, serial number, and total activity of the current gamma irradiator is withheld from this application.. ..
  23. Centers for Medical Countermeasures Against Radiation
    ALAN D ANDREA; Fiscal Year: 2009
    ..The program is designed to accelerate the development of new medical applications in the field of countermeasures against radiation. ..
  24. HIFs and VEGF in sarcoma progression, metastasis, and radiation response
    SAM SUNGHYUN YOON; Fiscal Year: 2013
    ..The methods of this proposal include analysis of sarcoma cell lines and primary endothelial cells in vitro, analysis of genetically engineered mouse models, and analysis of tumor tissue samples from sarcoma patients. ..
  25. Prediction Model for Radiation Sensitivity in Children with Cancer
    STELLA MARGARET DAVIES; Fiscal Year: 2010
    ....
  26. Hematopoietic targets of radiation: identification and mitigation
    James Palis; Fiscal Year: 2012
    ..PUBLIC HEALTH STATEMENT: The proposed research is designed to learn which blood cells in the bone marrow are sensitive to radiation and to learn how to protect these cells. ..
  27. Suppression of Glioblastoma Stem Cells by Kruppel-Like Factor 9
    John J Laterra; Fiscal Year: 2013
    ....
  28. Genetic Defects in a Novel Radiation Sensitive Syndrome
    Zhiyuan Shen; Fiscal Year: 2012
    ..Considering the hypersensitivity to radiation of the CoDa cells, this study will have strong impact on radiation biology and DNA repair fields. ..
  29. Double-Strand Break Repair and Genome Stability
    Paul Russell; Fiscal Year: 2013
    ..These studies will improve the conceptual understanding of how mutations in human Nbs1 cause cancer, and in doing so enhance opportunities for developing new strategies for cancer prevention and treatment. ..
  30. Monitoring Early Treatment Response of Human Primary Brain Tumors by Sodium MRI
    Keith R Thulborn; Fiscal Year: 2013
    ..Large treatment trials can be avoided. This imaging approach is an important step on the NIH roadmap towards personalized healthcare. ..
  31. Predicting Liver Function After Irradiation
    Yue Cao; Fiscal Year: 2013
    ..Our proposed approach is highly innovative and represents a new paradigm to investigate radiation toxicity in the liver. It has potential to be a tool for individualized therapy. ..
  32. 12th International Workshop on Ataxia-Telangiectasia and ATM
    Richard Gatti; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  33. INTERSTITIAL NEUTRON THERAPY FOR GLIOBLASTOMA
    ALFRED YOUNG; Fiscal Year: 1991
    ....
  34. Small-molecule inhibitors of the human RECQ1 and Bloom DNA helicases
    Opher Gileadi; Fiscal Year: 2009
    ..It is hoped, that such inhibition will make the cancer cells more sensitive to DNA- damaging agents, thus allowing better treatment options for patients with resistant forms of cancer. ..
  35. STORAGE PHOSPHOR FILM FOR RADIATION THERAPY DOSIMETRY
    HUI HAROLD LI; Fiscal Year: 2013
    ..abstract_text> ..
  36. Cylcin G1/S Expression and Radiation Sensitivity
    Francisco Pardo; Fiscal Year: 2004
    ..Ultimately, it is hoped that the translation of such knowledge will enhance care in the radiation oncology clinic. ..
  37. Top3 Homologues in Lymphocyte Genome Stability and Aging
    ALBERT SHAW; Fiscal Year: 2009
    ..abstract_text> ..
  38. Genetic Susceptibility Modifiers in Renal Cell Carcinoma
    Xifeng Wu; Fiscal Year: 2007
    ..Such individuals may then be targeted for intervention programs such as chemoprevention or dietary modification. ..
  39. CELL CONTACT INDUCED DRUG RESISTANCE
    Marilyn Cornwell; Fiscal Year: 1999
    ..The results of the proposed studies will provide novel insights into how multicellular growth influences the response of tumor cells to drug treatment and may provide insights applicable o increasing drug efficacy. ..
  40. OXYGEN LEVELS AND RADIOSENSITIVITY IN TUMORS
    David Wilson; Fiscal Year: 2001
    ..Phosphors will be selected which can be injected intravenously and then, after the oxygen measurements, are excreted by the kidney. ..
  41. Center for High-Throughput Minimally-Invasive Radiation Biodosimetry
    DAVID JONATHAN BRENNER; Fiscal Year: 2013
    ..Both of these approaches build on - and would not be possible without - the high-throughput biodosimetry work that we have accomplished to date. ..
  42. ROLES OF UBIQUITIN CONJUGATING ENZYMES IN DNA REPAIR
    Zhiyuan Shen; Fiscal Year: 2001
    ....
  43. ANALYSIS OF RADIATION INJURIES IN 440 OVERDOSED PATIENTS
    Timothy Schultheiss; Fiscal Year: 1993
    ..and physical findings (blood pressure, congenital defects etc.). 4. To perform case-control studies using dose-matched controls to ascertain the significance (relative risk) of factors other than dose in the radiation response...
  44. BASIC STUDIES OF EXPERIMENTAL TUMOR MODELS
    Robert Sutherland; Fiscal Year: 1992
    ....
  45. RADIATION INDUCED CHROMOSOME DAMAGE IN VIVO
    ANTONE BROOKS; Fiscal Year: 1991
    ..of aberrations? Third, how does the radiation sensitivity of the chromosomes change in cells exposed to internally deposited radioactive materials as the cells progress from normal to hyperplastic nodules and on to a neoplastic state?..
  46. Ceramide Synthase in Radiation-Induced Apoptosis
    Zvi Fuks; Fiscal Year: 2006
    ....
  47. Study of Valproic Acid in Pediatric Brain Tumors
    Jack Su; Fiscal Year: 2009
    ..In summary, Dr. Su's has demonstrated early promise in translating molecular discoveries into clinical trials, and he is committed to his career development as an independent clinical researcher in pediatric neuro-oncology. ..
  48. DNA PK IN RADIATION DAMAGE REPAIR AND LYMPHOMAGENESIS
    Gloria Li; Fiscal Year: 2002
    ..Furthermore, our studies should verify whether there is a role of Ku70 in lymphomagenesis, and specifically whether Ku70 may be considered as a candidate tumor suppressor gene. ..
  49. Repair of DNA Damages Induced by Ionizing Radiation
    Susan Wallace; Fiscal Year: 2009
    ..The ultimate goal is to develop strategies based on structure/function relationships that would increase the effective dose to the tumor without damaging the normal tissue. ..
  50. FAST LOW COST MR BREAST SCANNER AND NOVEL COMPACT MAGNET
    RICHARD RZEDZIAN; Fiscal Year: 1991
    ..In Phase II a magnetic prototype will be fabricated and the rest of the MR breast scanner will be develped. Initial clinical trials will be carried out to evaluate the performance of the scanner...
  51. Impact of Cell Cycle Checkpoints on DNA Repair
    Wolfram Siede; Fiscal Year: 2003
    ..Genetic instability has been recognized as a key process in the multistep sequence of events leading to human cancer. The project is therefore highly relevant to human health. ..
  52. END JOINING REACTION IN DNA REPAIR & V(D)J RECOMBINATION
    Gilbert Chu; Fiscal Year: 2005
    ..Experiments will determine whether phosphatases play a role in NHEJ, and identify physiologically relevant targets of DNA-PKcs. ..
  53. RADIATION ASSOCIATED GENE PRODUCTS
    WENGANG CHOU; Fiscal Year: 1992
    ..Results of this proposal will provide information on the molecular mechanism of radiation repair and sensitivity. The cDNAs may be able to serve as the marker for prediction of radiation responsiveness of human tumors...
  54. Molecular Targets for Drug and Radiation Sensitivity
    Stephen Hahn; Fiscal Year: 2007
    ..abstract_text> ..
  55. Clinical Trials of FTI Radiosensitization
    Stephen Hahn; Fiscal Year: 2005
    ..Specific molecular markers that are associated with activation of the Ras signaling pathway will be measured in NSCLC tumor biopsy specimens and will be related to the clinical efficacy of R115777 and radiotherapy. ..
  56. Targeted Gene Therapy for Neurologic disease
    Xandra Breakefield; Fiscal Year: 2005
    ..abstract_text> ..
  57. RESTORATION OF APOPTOSIS IN CANCER
    Jack Roth; Fiscal Year: 2003
    ..The studies included in the Program Project could lead to cancer treatments targeted to specific genetic lesions in the cancer cell, thus representing novel mechanisms of action that could complement existing therapies. ..
  58. Translational Control of Radiation-Induced Apoptosis
    Benjamin Chen; Fiscal Year: 2005
    ..With regard to the approaches, ..
  59. CD44 AND THE PATHOGENESIS OF HEMOPOIETIC MALIGNANCIES
    GRAEME DOUGHERTY; Fiscal Year: 2004
    ..This isoform can bind to and activate the adhesive function of cell surface CD44. ..
  60. MECHANISMS OF CELLULAR RESPONSES TO IONIZING RADIATION
    Anatoly Dritschilo; Fiscal Year: 2006
    ..Data from these projects will identify and validate targets for use in clinical radiation sensitizing strategies to improve the therapeutic ratio for the treatment of human cancers. ..
  61. MOLECULAR STUDIES OF RADIATION RESISTANT TUMOR CELLS
    Anatoly Dritschilo; Fiscal Year: 2000
    ..Such knowledge may identify useful molecular information for application in diagnostic and therapeutic strategies to improve the cancer treatment therapeutic ratio. ..
  62. Cancer radiotherapy: sensitization by inhibitors of PAR*
    Garry Southan; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATION: The annual anticipated revenues for an effective therapeutic to safely enhance radiation therapy is over $100 million in the US alone. ..
  63. Radiation-Induced Ceramide Generation
    Andrew Amoscato; Fiscal Year: 2006
    ..These results should provide valuable information for the identification of novel molecular targets for enhancing or decreasing ionizing radiation-induced apoptosis. [unreadable] [unreadable]..