Genomes and Genes
Summary: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Publications349 found, 100 shown here
- Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexesLee Zou
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Science 300:1542-8. 2003..Our data suggest that RPA-coated ssDNA is the critical structure at sites of DNA damage that recruits the ATR-ATRIP complex and facilitates its recognition of substrates for phosphorylation and the initiation of checkpoint signaling...
- Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconusGregor Wollensak
Department of Ophthalmology, Technical University of Dresden, Germany
Am J Ophthalmol 135:620-7. 2003..The aim of the present study was to evaluate the clinical usefulness of riboflavin/UVA-induced collagen crosslinking for bringing the progression of keratoconus to a halt...
- Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpointQ Liu
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
Genes Dev 14:1448-59. 2000..Taken together, these data indicate that Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppression, and that Atr regulates Chk1...
- Interaction of the Fanconi anemia proteins and BRCA1 in a common pathwayI Garcia-Higuera
Department of Pediatric Oncology, Dana Farber Cancer Institute, and Department of Pediatrics, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Mol Cell 7:249-62. 2001..The FANCD2 protein, therefore, provides the missing link between the FA protein complex and the cellular BRCA1 repair machinery. Disruption of this pathway results in the cellular and clinical phenotype common to all FA subtypes...
- A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damageDanny M Chou
Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:18475-80. 2010..We propose that PARP sets up a transient repressive chromatin structure at sites of DNA damage to block transcription and facilitate DNA repair...
- Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linkingGregor Wollensak
Department of Ophthalmology, Technical University of Dresden, Dresden, Germany
J Cataract Refract Surg 29:1780-5. 2003..To evaluate the biomechanical effect of combined riboflavin-ultraviolet A (UVA) treatment on porcine and human corneas...
- Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathwayC Tournier
Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 288:870-4. 2000..These data indicate that mitochondria are influenced by proapoptotic signal transduction through the JNK pathway...
- Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term resultsFrederik Raiskup-Wolf
Department of Ophthalmology, C G Carus University Hospital, Dresden, Germany
J Cataract Refract Surg 34:796-801. 2008..To prove the long-term dampening effect of riboflavin- and ultraviolet-A-induced collagen crosslinking on progressive keratoconus...
- Mechanisms of photoaging and chronological skin agingGary J Fisher
Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
Arch Dermatol 138:1462-70. 2002..This article reviews our current understanding and presents new data about the molecular pathways that mediate skin damage by UV irradiation and by the passage of time...
- Safety of UVA-riboflavin cross-linking of the corneaEberhard Spoerl
Department of Ophthalmology, Universitatsklinikum Dresden, Dresden, Germany
Cornea 26:385-9. 2007..To study potential damage to ocular tissue during corneal collagen cross-linking (X-linking) by means of the riboflavin/UVA (370 nm) approach...
- The evolution of human skin colorationN G Jablonski
Department of Anthropology, California Academy of Sciences, Golden Gate Park, San Francisco, CA 94118 4599, USA
J Hum Evol 39:57-106. 2000..Skin pigmentation levels have changed more than once in human evolution. Because of this, skin coloration is of no value in determining phylogenetic relationships among modern human groups...
- Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damageHengbin Wang
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Kaul Human Genetics Building Room 402A, 720 South 20th Street, 35294, USA
Mol Cell 22:383-94. 2006..Thus, our studies uncover CUL4-DDB-ROC1 as a histone ubiquitin ligase and demonstrate that histone H3 and H4 ubiquitylation participates in the cellular response to DNA damage...
- Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage responseJurgen A Marteijn
Department of Genetics, Center for Biomedical Genetics, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
J Cell Biol 186:835-47. 2009..Although both lesions are processed by independent repair pathways and trigger signaling responses by distinct kinases, they eventually generate the same epigenetic mark, possibly functioning in DNA damage signal amplification...
- DNA damage response and transcriptionSaskia Lagerwerf
Department of Toxicogenetics, Leiden University Medical Center, 2333 RC Leiden, The Netherlands
DNA Repair (Amst) 10:743-50. 2011....
- Mutations induced by ultraviolet lightGerd P Pfeifer
Department of Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
Mutat Res 571:19-31. 2005..We also discuss the role of DNA damage-tolerant DNA polymerases in UV lesion bypass and mutagenesis...
- INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathwayYingjun Jiang
Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 107:17274-9. 2010..These results demonstrate a critical role of INO80 in creating DNA accessibility for the NER pathway and provide direct evidence that repair of UV lesions and perhaps most bulky adduct lesions requires chromatin reconfiguration...
- The AtGenExpress global stress expression data set: protocols, evaluation and model data analysis of UV-B light, drought and cold stress responsesJoachim Kilian
Zentrum für Molekularbiologie der Pflanzen, Pflanzenphysiologie, Universitat Tubingen, Auf der Morgenstelle 1, 72076 Tubingen, Germany
Plant J 50:347-63. 2007..In summary, the information reported provides a prime reference point and source for the subsequent exploitation of this important resource for research into plant abiotic stress...
- The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sitesMaria G Kapetanaki
Department of Molecular Genetics and Biochemistry, School of Medicine, and Cancer Institute, University of Pittsburgh, Hillman Cancer Center, Research Pavilion, Suite 2 6, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
Proc Natl Acad Sci U S A 103:2588-93. 2006....
- Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cellsTomoo Ogi
Department of Molecular Medicine, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4, Sakamoto, Nagasaki 852 8523, Japan
Mol Cell 37:714-27. 2010..The remaining repair synthesis is dependent on pol epsilon, recruitment of which is dependent on the alternative clamp loader CTF18-RFC...
- UV-light-induced signal cascades and skin agingLaure Rittie
Department of Dermatology, University of Michigan, 1150 West Medical Center Drive, R6447 Medical Science I, Ann Arbor, MI 48109 0609, USA
Ageing Res Rev 1:705-20. 2002....
- Melanocytes are deficient in repair of oxidative DNA damage and UV-induced photoproductsHsiang Tsui Wang
Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
Proc Natl Acad Sci U S A 107:12180-5. 2010....
- Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytesHui Qin Wang
Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0609, USA
J Biol Chem 278:45737-45. 2003..These data demonstrate that PI3K/Akt is essential for protecting human KCs against UV-induced apoptosis, whereas NF-kappaB pathway provides little, if any, protective role...
- Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiationSergey Alekseev
Department of Toxicogenetics, Leiden University Medical Center, Leiden University, Leiden, The Netherlands
Cancer Res 65:10298-306. 2005..Our results show an important role for DDB2 in the protection against UV-induced cancer and indicate that this protection is most likely mediated by accelerating the repair of photolesions...
- Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitinationKenji Watanabe
Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
EMBO J 23:3886-96. 2004..These results suggest that Rad18 is crucial for recruitment of poleta to the damaged site through protein-protein interaction and PCNA monoubiquitination...
- PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complexTarek Abbas
Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
Genes Dev 22:2496-506. 2008..Finally, we show that the CRL4(Cdt2) and the SCF(Skp2) ubiquitin ligases are redundant with each other in promoting the degradation of p21 during an unperturbed S phase of the cell cycle...
- Ubiquitin-dependent DNA damage bypass is separable from genome replicationYasukazu Daigaku
Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms EN6 3LD, UK
Nature 465:951-5. 2010..Our approach has revealed the distribution of PRR tracts in a synchronized cell population. It will allow an in-depth mechanistic analysis of how cells manage the processing of lesions to their genomes during and after replication...
- Perception of UV-B by the Arabidopsis UVR8 proteinLuca Rizzini
Faculty of Biology, Institute of Biology II, University of Freiburg, D 79104 Freiburg, Germany
Science 332:103-6. 2011..Thereby this signaling cascade controlled by UVR8 mediates UV-B photomorphogenic responses securing plant acclimation and thus promotes survival in sunlight...
- The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damageRegina Groisman
Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cell 113:357-67. 2003..Knockdown of CSN with RNA interference leads to defects in NER. These results suggest that the distinct UV response of the DDB2 and CSA complexes is involved in diverse mechanisms of NER...
- Increased resistance of crosslinked cornea against enzymatic digestionEberhard Spoerl
Department of Ophthalmology, Universitatsklinikum CGC, Fetscherstrasse 74, D 01307 Dresden, Germany
Curr Eye Res 29:35-40. 2004..Recently, we have started to use the same method for the treatment of corneal ulcers. The aim of the present study was to evaluate the influence of the crosslinking treatment on the resistance of the cornea against enzymatic degradation...
- UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complexKaoru Sugasawa
Cellular Physiology Laboratory, RIKEN Discovery Research Institute, Japan Science and Technology Agency, Wako, Saitama 351 0198, Japan
Cell 121:387-400. 2005..Our results strongly suggest that ubiquitylation plays a critical role in the transfer of the UV-induced lesion from UV-DDB to XPC...
- NER and DDR: classical music with new instrumentsSarah Sertic
Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Milano, Italy
Cell Cycle 11:668-74. 2012..Here, we review the connections between NER processing of UV-induced lesions and checkpoint activation, discussing the role of recently identified players in this mechanism...
- Plant UVR8 photoreceptor senses UV-B by tryptophan-mediated disruption of cross-dimer salt bridgesJohn M Christie
Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
Science 335:1492-6. 2012..Our analyses establish how UVR8 functions as a photoreceptor without a prosthetic chromophore to promote plant development and survival in sunlight...
- Structural basis of ultraviolet-B perception by UVR8Di Wu
Tsinghua Peking Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China
Nature 484:214-9. 2012....
- DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicityNoam Diamant
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Nucleic Acids Res 40:170-80. 2012..Such a mechanism may function to maintain efficient replication, which can progress despite the presence of DNA lesions, with TLS lagging behind and patching regions of discontinuity...
- The mechanisms of UV mutagenesisHironobu Ikehata
Division of Genome and Radiation Biology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai, Japan
J Radiat Res 52:115-25. 2011..In contrast, it has been demonstrated that UVA exclusively induces the solar-UV signature mutations in vivo through CPD formation...
- Sequential assembly of translesion DNA polymerases at UV-induced DNA damage sitesParker L Andersen
Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, S7N 5E5, Canada
Mol Biol Cell 22:2373-83. 2011..These observations suggest a cooperative and sequential assembly of TLS polymerases in response to DNA damage. They also support and extend the current polymerase switch model...
- Transcription factor ATF2 regulation by the JNK signal transduction pathwayS Gupta
Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605
Science 267:389-93. 1995..Furthermore, expression of dominant-negative JNK inhibited ATF2 transcriptional activity. Together, these data demonstrate a role for the JNK signal transduction pathway in transcriptional responses mediated by ATF2...
- Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanismsJoi A Nichols
Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall 557, PO Box 202, Birmingham, AL 35294, USA
Arch Dermatol Res 302:71-83. 2010..It is suggested that polyphenols may favorably supplement sunscreens protection, and may be useful for skin diseases associated with solar UV radiation-induced inflammation, oxidative stress and DNA damage...
- Suppression of melanin production by expression of HSP70Tatsuya Hoshino
Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
J Biol Chem 285:13254-63. 2010..This study provides the first evidence of an inhibitory effect of HSP70 on melanin production both in vitro and in vivo. This effect seems to be mediated by modulation of MITF activity through a direct interaction between HSP70 and MITF...
- Regulation of monoubiquitinated PCNA by DUB autocleavageTony T Huang
Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Nat Cell Biol 8:339-47. 2006..Our results define a regulatory mechanism for protein ubiquitination that involves the signal-induced degradation of an inhibitory DUB...
- UVB-induced premature senescence of human diploid skin fibroblastsFlorence Chainiaux
Laboratory of Cellular Biochemistry and Biology, Department of Biology, University of Namur FUNDP, Rue de Bruxelles 61, B 5000, Namur, Belgium
Int J Biochem Cell Biol 34:1331-9. 2002..This model could be used to test whether HDFs in UVB-induced premature senescence are able to promote epithelial cell growth and tumorigenesis in skin, as shown recently with HDFs in H(2)O(2)-induced premature senescence...
- Ultraviolet irradiation-induces epidermal growth factor receptor (EGFR) nuclear translocation in human keratinocytesYiru Xu
Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Cell Biochem 107:873-80. 2009..EGFR nuclear translocation may act in concert with conventional signaling pathways to mediate UV irradiation-induced responses in human keratinocytes...
- PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpointsXiongbin Lu
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
Genes Dev 19:1162-74. 2005..These homeostatic functions may be partially responsible for the oncogenic effects of PPM1D when it is amplified and overexpressed in human tumors...
- The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: a role for UVA in human skin carcinogenesisNita S Agar
Dermatology Research Unit, Melanoma and Skin Cancer Research Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital, University of Sydney, Sydney NSW 2006, Australia
Proc Natl Acad Sci U S A 101:4954-9. 2004..Given the traditional emphasis on UVB, these results may have profound implications for future public health initiatives for skin cancer prevention...
- Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesisGargi Ghosal
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 287:34225-33. 2012..Thus, C1orf124 acts at multiple steps in TLS, stabilizes RAD18 and ubiquitinated PCNA at damage sites, and facilitates the switch from replicative to TLS polymerase to bypass DNA lesion...
- Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesionsMassimo Lopes
Department of Biology, Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
Mol Cell 21:15-27. 2006....
- Perifosine sensitizes UVB-induced apoptosis in skin cells: new implication of skin cancer prevention?Chao Ji
Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210024, Jiangsu, China
Cell Signal 24:1781-9. 2012..Our results suggest that perifosine may represent a novel skin cancer prevention strategy...
- Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross studyAldo Caporossi
Department of Ophthalmology and Neurosurgery, Santa Maria delle Scotte Hospital, Siena University, Siena, Italy
Am J Ophthalmol 149:585-93. 2010..To report the long-term results of 44 keratoconic eyes treated by combined riboflavin ultraviolet A collagen cross-linking in the first Italian open, nonrandomized phase II clinical trial, the Siena Eye Cross Study...
- Cutaneous melanoma attributable to sunbed use: systematic review and meta-analysisMathieu Boniol
International Prevention Research Institute, 95 cours Lafayette, 69006 Lyon, France
BMJ 345:e4757. 2012..To estimate the burden of melanoma resulting from sunbed use in western Europe...
- Equivalence of biomechanical changes induced by rapid and standard corneal cross-linking, using riboflavin and ultraviolet radiationSilvia Schumacher
IROC AG, Institute of Refractive and Ophthalmic Surgery, Stockerstrasse 37, Zurich, Switzerland
Invest Ophthalmol Vis Sci 52:9048-52. 2011..The authors evaluated whether a rapid treatment protocol (higher intensity and shorter irradiation time) could achieve the same increase in corneal stiffness as the currently used standard protocol...
- Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complexAndrea Scrima
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Cell 135:1213-23. 2008..The structure provides insights into damage recognition in chromatin and suggests a mechanism by which the DDB1-associated CUL4 ubiquitin ligase targets proteins surrounding the site of damage...
- Human skin pigmentation: melanocytes modulate skin color in response to stressGertrude E Costin
Avon Products, Inc, New Technology Department, 1 Avon Pl, Suffern, NY 10901, USA
FASEB J 21:976-94. 2007..g., to design tanning products with potential to reduce skin cancer risk)...
- Prevalence of sunburn, sun protection, and indoor tanning behaviors among Americans: review from national surveys and case studies of 3 statesDavid B Buller
Klein Buendel Inc, Golden, Colorado 80439, USA
J Am Acad Dermatol 65:S114-23. 2011..Exposure to ultraviolet radiation (from solar and nonsolar sources) is a risk factor for skin cancer...
- The UV response of the skin: a review of the MAPK, NFkappaB and TNFalpha signal transduction pathwaysVisalini Muthusamy
School of Medical Sciences, RMIT University, PO Box 71, Bundoora, VIC 3083, Australia
Arch Dermatol Res 302:5-17. 2010..Once the function of these pathways is known, this information may provide for the formulation of therapy which will prevent the release of immunosuppressive cytokines resulting in a reduction in skin cancer formation...
- Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during developmentHannes Lans
Department of Genetics, Medical Genetics Center, Erasmus MC, Rotterdam, The Netherlands
PLoS Genet 6:e1000941. 2010..These in vivo studies strongly suggest that involvement of different repair pathways and chromatin remodeling proteins in UV-induced DNA repair depends on developmental stage of cells...
- DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δAndrey G Baranovskiy
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
J Biol Chem 287:17281-7. 2012....
- Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian studyAldo Caporossi
Department of Ophthalmological and Neurosurgical Sciences, Siena University, Siena, Italy
J Cataract Refract Surg 32:837-45. 2006..To assess the effectiveness of riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen in reducing progression of keratoconus and in improving visual acuity in patients with progressive keratoconus...
- DDB2 promotes chromatin decondensation at UV-induced DNA damageMartijn S Luijsterburg
Department of Cell and Molecular Biology, Karolinska Institutet, S 17177 Stockholm, Sweden
J Cell Biol 197:267-81. 2012..Finally, we show that lesion recognition by XPC, but not DDB2, was strongly reduced in ATP-depleted cells and was regulated by the steady-state levels of poly(ADP-ribose) chains...
- UV-induced DNA damage and repair: a reviewRajeshwar P Sinha
Institut fur Botanik und Pharmazeutische Biologie, Friedrich Alexander Universitat, Staudtstr 5, D 91058 Erlangen, Germany
Photochem Photobiol Sci 1:225-36. 2002..This review deals with UV-induced DNA damage and the associated repair mechanisms as well as methods of detecting DNA damage and its future perspectives...
- PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cellsAyal Hendel
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
PLoS Genet 7:e1002262. 2011..However, TLS polymerases can be recruited to damaged DNA also in the absence of PCNA-Ub, and perform TLS, albeit at a significantly lower efficiency and altered mutagenic specificity...
- Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulationBo Yie Chen
School of Optometry, Chung Shan Medical University, Taichung, Taiwan, ROC
Mol Vis 17:854-63. 2011..This study aims to determine the effect of zerumbone, a potent NF-κB inhibitor and inflammation modulators, on UVB-induced corneal damages in a mouse model...
- Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, PoletaR E Johnson
Sealy Center for Molecular Science, University of Texas Medical Branch at Galveston, 6 104 Medical Research Building, 11th and Mechanic Streets, Galveston, TX 77555 1061, USA
Science 283:1001-4. 1999..When incubated in vitro with all four nucleotides, Rad30 incorporates two adenines opposite the thymine-thymine dimer. Rad30 is the seventh eukaryotic DNA polymerase to be described and hence is named DNA polymerase eta...
- E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiationMichael P Underbrink
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
J Virol 82:10408-17. 2008..In conclusion, several of the beta-HPV types possess the ability to protect UV-treated keratinocytes from apoptosis by reducing levels of Bak in those cells, thus blocking the intrinsic apoptotic pathway...
- UV-induced skin damageM Ichihashi
Division of Dermatology, Graduate School of Medicine, Translational Medicine, School of Medicine, Kobe University, Kobe, Japan
Toxicology 189:21-39. 2003..Finally, possible prevention of UV-induced skin cancer by feeding or topical use of antioxidants, such as polyphenols, vitamin C, and vitamin E, is discussed...
- Modulation of nucleotide excision repair by mammalian SWI/SNF chromatin-remodeling complexQun Zhao
Department of Radiology, The Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 284:30424-32. 2009....
- The epidemiology of UV induced skin cancerB K Armstrong
Cancer Research and Registers Division, New South Wales Cancer Council, PO Box 572, Kings Cross 2011, Australia
J Photochem Photobiol B 63:8-18. 2001....
- Arabidopsis mutants lacking phenolic sunscreens exhibit enhanced ultraviolet-B injury and oxidative damageL G Landry
Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853 1801, USA
Plant Physiol 109:1159-66. 1995..thaliana, hydroxycinnamates are more effective UV-B protectants than flavonoids. The data also indicate that A. thaliana responds to UV-B as an oxidative stress, and sunscreen compounds reduce the oxidative damage caused by UV-B...
- Ultraviolet light induced injury: immunological and inflammatory effectsG J Clydesdale
Discipline of Pathology, University of Tasmania, Hobart, Tasmania, Australia
Immunol Cell Biol 79:547-68. 2001....
- PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signalingRuichuan Chen
Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian, China
Genes Dev 22:1356-68. 2008..Thus, through cooperatively dephosphorylating Cdk9 in response to Ca2+ signaling, PP2B and PP1alpha alter the P-TEFb functional equilibrium through releasing P-TEFb from 7SK snRNP for transcription...
- Cellular UV damage responses--functions of tumor suppressor p53Leena Latonen
Molecular and Cancer Biology Program and Haartman Institute, University of Helsinki, PO Box 63, FIN 00014 Helsinki, Finland
Biochim Biophys Acta 1755:71-89. 2005..In this review, we discuss UV damage-provoked cellular responses and the functions of p53 in damage recovery and cell death...
- CUL4A abrogation augments DNA damage response and protection against skin carcinogenesisLiren Liu
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
Mol Cell 34:451-60. 2009....
- Profiling of UV-induced ATM/ATR signaling pathwaysMatthew P Stokes
Cell Signaling Technology, 3 Trask Lane, Danvers, MA 01923, USA
Proc Natl Acad Sci U S A 104:19855-60. 2007..Together, these results provide a rich resource for further deciphering ATM/ATR signaling and the pathways mediating the DNA damage response...
- Heterochromatin protein 1 is recruited to various types of DNA damageMartijn S Luijsterburg
Swammerdam Institute for Life Sciences, Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1012 WX Amsterdam, Netherlands
J Cell Biol 185:577-86. 2009..Our results show that HP1 proteins are important for DNA repair and may function to reorganize chromatin in response to damage...
- UV stalled replication forks restart by re-priming in human fibroblastsIngegerd Elvers
Department of Genetics, Microbiology and Toxicology, Stockholm University, S 10691 Stockholm, Sweden
Nucleic Acids Res 39:7049-57. 2011..If left unfilled, the gaps may collapse into DNA double-strand breaks that are repaired by a recombination pathway, similar to the fate of replication forks collapsed after hydroxyurea treatment...
- The xeroderma pigmentosum pathway: decision tree analysis of DNA qualityHanspeter Naegeli
Institute of Pharmacology and Toxicology, University of Zurich Vetsuisse, Zurich, Switzerland
DNA Repair (Amst) 10:673-83. 2011..The present review is focused on the mechanisms by which multiple XP subunits of the NER pathway contribute to the proposed decision tree analysis of DNA quality in eukaryotic cells...
- Mammalian polymerase zeta is essential for post-replication repair of UV-induced DNA lesionsJacob G Jansen
Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, PO Box 9600, 2300 RC Leiden, The Netherlands
DNA Repair (Amst) 8:1444-51. 2009..The deficiency of Rev3(-/-) MEFs in post-replication repair of different photoproducts contributes to the extreme sensitivity of these cells to UV light...
- CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiationHideo Nishitani
Graduate School of Life Science, University of Hyogo, Kamigori, Ako gun, Hyogo, 678 1297, Japan
J Biol Chem 283:29045-52. 2008..Mutational analysis suggested that in addition to the PCNA binding domain, its flanking regions are also important for recognition by Cul4-DDB1(Cdt2). Our findings provide a new aspect of proteolytic control of p21 during the cell cycle...
- Cellular mechanisms regulating human melanogenesisH Y Park
Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA
Cell Mol Life Sci 66:1493-506. 2009..These events are tightly regulated by a variety of paracrine and autocrine factors in response to endogenous and exogenous stimuli, principally UV irradiation...
- A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damageT T Paull
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0540, USA
Curr Biol 10:886-95. 2000..Recently it has been reported that a member of the histone H2A family, H2AX, becomes extensively phosphorylated within 1-3 minutes of DNA damage and forms foci at break sites...
- Spores of Bacillus subtilis: their resistance to and killing by radiation, heat and chemicalsP Setlow
Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, 06030 3305, USA
J Appl Microbiol 101:514-25. 2006..Given the importance of the killing of spores of Bacillus species in the food and medical products industry, a deeper understanding of the mechanisms of spore resistance and killing may lead to improved methods for spore destruction...
- hRAD30 mutations in the variant form of xeroderma pigmentosumR E Johnson
Sealy Center for Molecular Science, University of Texas Medical Branch at Galveston, 6 104 Medical Research Building, 11th and Mechanic Streets, Galveston, TX 77555 1061, USA
Science 285:263-5. 1999..These results indicate that defects in hRAD30 cause XP-V, and they suggest that error-free replication of UV lesions by hRad30 plays an important role in minimizing the incidence of sunlight-induced skin cancers...
- Spatial and temporal cellular responses to single-strand breaks in human cellsSatoshi Okano
Department of Molecular Genetics, Institute of Development, Aging and Cancer, Tohoku University, 980 8575 Sendai, Japan
Mol Cell Biol 23:3974-81. 2003..Our results show the importance of poly(ADP-ribosyl)ation in sequential cellular responses to SSB...
- Toxic effects of ultraviolet radiation on the skinYasuhiro Matsumura
Department of Dermatology, Kansai Medical University, Osaka 570 8507, Japan
Toxicol Appl Pharmacol 195:298-308. 2004..Although such therapy is beneficial, it is accompanied with undesirable side effects. Thus, UV radiation is like two sides of the same coin--on one side, it has detrimental effects, and on the other side, it has beneficial effects...
- Corneal collagen cross-linking with riboflavin and ultraviolet-A irradiation in patients with thin corneasGeorge D Kymionis
Institute of Vision and Optics, University of Crete, Heraklion, Crete, Greece
Am J Ophthalmol 153:24-8. 2012....
- Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneasFarhad Hafezi
Institute for Refractive and Ophthalmic Surgery, Zurich, Switzerland
J Cataract Refract Surg 35:621-4. 2009..Preoperative swelling of the cornea safely broadens the spectrum of CXL indications to thin corneas that would otherwise not be eligible for treatment...
- Nucleotide excision repair in human cells: fate of the excised oligonucleotide carrying DNA damage in vivoJinchuan Hu
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7260, USA
J Biol Chem 288:20918-26. 2013..Taken together, our results show the congruence of in vivo and in vitro data on nucleotide excision repair in humans. ..
- UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repairPetra Schwertman
Department of Genetics and Netherlands Proteomics Centre, Centre for Biomedical Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands
Nat Genet 44:598-602. 2012..Together, these findings indicate that UVSSA-USP7–mediated stabilization of ERCC6 represents a critical regulatory mechanism of TC-NER in restoring gene expression...
- Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damagePatricia L Kannouche
Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
Mol Cell 14:491-500. 2004..Our findings provide an attractive mechanism by which monoubiquitination of PCNA might mediate the polymerase switch...
- Use of the rpoB gene to determine the specificity of base substitution mutations on the Escherichia coli chromosomeLilit Garibyan
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
DNA Repair (Amst) 2:593-608. 2003..Because of the conservation of key regions of RNA polymerase among many microorganisms, using the Rif(r)/rpoB system may be a general method for studying mutational processes in microorganisms without well developed genetic systems...
- Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinaseD V Bulavin
Division of Basic Science, National Cancer Intitute, National Institutes of Health, Bethesda, MD 20892, USA
Nature 411:102-7. 2001..We propose that regulation of Cdc25B phosphorylation by p38 is a critical event for initiating the G2/M checkpoint after ultraviolet radiation...
- Highly error-free role of DNA polymerase eta in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cellsJung Hoon Yoon
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 1061, USA
Proc Natl Acad Sci U S A 106:18219-24. 2009..These observations have important bearing on how mammalian cells have adapted to avoid the mutagenic and carcinogenic consequences of exposure to sunlight...
- ATP-dependent chromatin remodeling facilitates nucleotide excision repair of UV-induced DNA lesions in synthetic dinucleosomesK Ura
Division of Gene Therapy Science, Osaka University School of Medicine, 2 2 Yamada oka, Suita, Japan
EMBO J 20:2004-14. 2001..Our results indicate that there is a functional connection between chromatin remodeling and the initiation step of NER...
- RPA2 is a direct downstream target for ATR to regulate the S-phase checkpointErin Olson
Department of Molecular and Experimental Medicine, The Scripps Research Institute, LA, Jolla, California 92037, USA
J Biol Chem 281:39517-33. 2006..Our studies suggest that in response to UV-induced DNA damage, ATR rapidly phosphorylates RPA2, disrupting its association with replication centers in the S-phase and contributing to the inhibition of DNA replication...
- UV as an amplifier rather than inducer of NF-kappaB activityEllen L O'Dea
Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0375, USA
Mol Cell 30:632-41. 2008..Our work suggests that the human health relevance of NF-kappaB activation by UV lies with cellular homeostatic states that are associated with pathology rather than with healthy physiology...
- Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNAJuliana Speroni
Cell Cycle and Genomic Stability Laboratory, Fundación Instituto Leloir Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina, Universidad de Buenos Aires, C1405BWE Buenos Aires, Argentina
Proc Natl Acad Sci U S A 109:7344-9. 2012..This kinase-independent role of Chk1 is exclusively associated to the maintenance of active replication forks after UV irradiation in a manner in which Chk1 release prompts TLS to avoid replication stalling...
- Factors that influence the cutaneous synthesis and dietary sources of vitamin DTai C Chen
Vitamin D, Skin and Bone Research Laboratory, Endocrine Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
Arch Biochem Biophys 460:213-7. 2007....
- The ING1b tumor suppressor facilitates nucleotide excision repair by promoting chromatin accessibility to XPAWei Hung W Kuo
Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, The University of British Columbia, Vancouver, Canada BC V6H 3Z6
Exp Cell Res 313:1628-38. 2007..Taken together, these observations establish a role of ING1b acting as a chromatin accessibility factor for DNA damage recognition proteins upon genotoxic injury...
- SUMO-dependent regulation of centrin-2Ulf R Klein
Department of Cell Biology, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
J Cell Sci 122:3312-21. 2009..These data show that the nucleocytoplasmic shuttling of centrin-2 depends on the SUMO system and indicates that localization of centrin-2 within the nucleus depends on its ability to bind to the XPC protein...
- Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activationYoshihiro Tsuchiya
Laboratory of Biomedical Chemistry, Department of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8553, Japan
Mol Cell 39:570-82. 2010..NF-kappaB activated by the nuclear IKKbeta adaptor protein suppresses anti-apoptotic gene expression and promotes UV-induced cell death...
- Differential regulation of hyaluronan metabolism in the epidermal and dermal compartments of human skin by UVB irradiationMarco Averbeck
Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, Leipzig, Germany
J Invest Dermatol 127:687-97. 2007..These data demonstrate that there is a complex temporal and spatial regulation of HA-metabolism in skin in response to UVB irradiation...
- Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-kappaB signaling in in vivo SKH-1 hairless miceSom D Sharma
Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
Mol Cancer Ther 6:995-1005. 2007....
- Intra-operative confocal imaging-guided Mohs surgeryMilind Rajadhyaksha; Fiscal Year: 2006..The overall goal is to develop an optical (confocal) intra-operative imaging instrument for Mohs and other modes of microsurgery. ..
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2013..Participants must agree to protect themselves from sunlight or artificial ultraviolet rays while in this study. - Participants will be screened with a physical exam and medical history...
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2012..Participants must agree to protect themselves from sunlight or artificial ultraviolet rays while in this study. - Participants will be screened with a physical exam and medical history...
- Evaluation of a Pulsed-Xenon Ultraviolet Room Disinfection DeviceJohn Zeber; Fiscal Year: 2013..However, portable machines emitting pulsed xenon ultraviolet rays (PX-UV) waves represent an effective, convenient solution for providing safer patient environments without ..
- Prevention of skin cancer by green tea polyphenolsSantosh Katiyar; Fiscal Year: 2009..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
- Prevention of UV-carcinogenesis by antioxidantSantosh Katiyar; Fiscal Year: 2004..abstract_text> ..
- Prevention of Photocarcinogenesis by antioxidantSantosh Katiyar; Fiscal Year: 2003..abstract_text> ..
- Proanthocyanidins: Novel Skin Cancer Preventive AgentSantosh Katiyar; Fiscal Year: 2006..Prevention of skin cancer risk will result to protect and prolong the human health and lives. ..
- SUN SAFETY FOR HIGH ALTITUDE SKI AREA STAFF AND GUESTSDavid Buller; Fiscal Year: 2002..Program implementation will be monitored by telephone at the control ski areas and intervention ski areas in the 2002-03 ski season to assess adoption and institutionalization. ..
- INTERNET--A CHANGE AGENT FOR RURAL MULTICULTURAL ADULTSDavid Buller; Fiscal Year: 2003..They will be posttested by telephone by AMC's Computer-assisted Telephone Interviewing Core. Adults in the control condition will be wait-listed for the intervention, which will be available after they complete the posttest. ..
- ARRESTING SMOKING UPTAKE USING INTERACTIVE MULTIMEDIADavid Buller; Fiscal Year: 2001..A feasibility study will be conducted that monitors access and use of it by community organizations and schools serving adolescents, especially those at high risk (e.g., low academic attainment, truancy). ..
- Keratinocyte-derived immuno-suppressive cytokinesStephen Ullrich; Fiscal Year: 2005..A better understanding of the mechanisms involved may help with the design of rational approaches to block the induction of immune suppression, thereby reducing one of the major risk factors for skin cancer induction. ..
- The XP Variant: A Human Mutator Gene for UV DamageJames Cleaver; Fiscal Year: 2005..We will express hRad3O on the keratin 14 promoter for over-expression in the skin, and make targeted knockout of mRad3O in vivo to identify roles for hRad3O in promoting and preventing carcinogenesis. ..
- Do NKT cells mediate UV induced Immune Suppression?Stephen Ullrich; Fiscal Year: 2005..A better understanding of the mechanisms involved in UV-induced immune suppression may help with the design of rational approaches to block immune suppression, thereby reducing one of the major risk factors for skin cancer induction. ..
- The Etiology of UV-Induced MelanomaDavid L Mitchell; Fiscal Year: 2010..From these studies we hope to define the effective solar wavelength boundaries of melanoma, identify the class of DNA damage critical to CMM and elucidate the role of DNA repair in tumor suppression. ..
- Inflammatory mediators and UV-induced carcinogenesisStephen Ullrich; Fiscal Year: 2009..The focus of the studies presented here is to provide evidence to support the hypothesis that these drugs can act as novel agents to prevent skin cancer formation. ..
- Randomized Trial on Web-based Quit Smoking ProgramDavid B Buller; Fiscal Year: 2010..Cost-effectiveness analyses will be performed at follow-up. ..
- SUNNY DAYS HEALTHY WAYS GRADES 6-8 SUN SAFETY CURRICULUMDavid Buller; Fiscal Year: 2002....
- WEB BASED SUPPORT--COMMUNITY TOBACCO CONTROL COALITIONSDavid Buller; Fiscal Year: 2003..abstract_text> ..
- DNA Damage and Neurodegeneration in Cockayne SyndromeJames Cleaver; Fiscal Year: 2009..Successful conclusion of these studies will expand our knowledge of mechanisms of neurodegeneration and lay groundwork for development of therapeutic approaches for CS patients. ..
- Disseminating Go Sun Smart to a Recreation IndustryDavid Buller; Fiscal Year: 2007..unreadable] [unreadable]..
- Dissemination: Increasing Physical ActivityDavid Buller; Fiscal Year: 2004..Students and young scientists will be encouraged to submit proposals for a poster session at the conference, and awards for the best submitted posters will be made. ..
- Diffusing Sun Safe Policies and Environments to SchoolsDavid Buller; Fiscal Year: 2008..On-site observations of sun protection policies, environmental features, and employee clothing will validate principal reports. [unreadable] [unreadable]..
- Elevated potassium ion in lacrimal fluid and the health of the ocular surfaceJohn Ubels; Fiscal Year: 2009..If the high potassium in tears is important for the health of the ocular surface, this information will be useful in the development of improved treatments for dry eye disease. ..
- UV-induced and NOS-mediated Zn elevation, translation regulatin and apoptosis.Shiyong Wu; Fiscal Year: 2007..g., reperfusion, wound healing, diabetes) that are affected by NO and translation inhibition. ..
- Analysis of Lacrimal Gland by Laser MicrodissectionJohn Ubels; Fiscal Year: 2003..abstract_text> ..
- MELANOMA CONTROL FOR SIBLING OF MELANOMA PATIENTSBarbara Gilchrest; Fiscal Year: 2001....
- Trace elements among Iowa pesticide applicatorsLeslie Dennis; Fiscal Year: 2004..abstract_text> ..
- Telomere-Mediated Protective Responses in SkinBarbara Gilchrest; Fiscal Year: 2007..The studies will also explore the possible therapeutic potential of T-oligos that comparably induce these responses in the absence of actual DNA damage or telomere disruption. ..
- Tanning bed use among UI StudentsLeslie Dennis; Fiscal Year: 2003..abstract_text> ..
- A new method for delivery of selinium for prevention of melanomaPamela Cassidy; Fiscal Year: 2007..This proposal revisits selenium as a melanoma preventive agent with an updated molecular rational and new strategy for delivery of this agent to the target organ, the skin. [unreadable] [unreadable] [unreadable]..
- Role of CRH in skin physiology and pathologyAndrzej Slominski; Fiscal Year: 2004..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..
- Vitamin D insufficiency: Prevalence and Impact in Young School Age ChildrenKumaravel Rajakumar; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSIONLoren Fast; Fiscal Year: 2002..abstract_text> ..
- Stress & UV-induced Squamous Cell CarcinomaFirdaus S Dhabhar; Fiscal Year: 2010..These studies are important in light of increasing morbidity and mortality associated with skin cancer, the ubiquitous nature of stress, and our preliminary findings on the effects of stress on SCC. ..
- Characterization of MBD3L1 and MBD3L2GERD PFEIFER; Fiscal Year: 2008..Since both proteins are likely functioning as transcriptional regulators, it will be important to determine if there are changes in gene expression patterns in Mbd311 and Mbd312 (-/-) cells. ..
- Prevention of Postmenopausal Bone Loss with Nitric OxideSunil Wimalawansa; Fiscal Year: 2007..The study will also pave the way for the future, for providing more acceptable, affordable and cost- effective therapies for the prevention of postmenopausalosteoporosis. ..
- Development of a nanosecond pulsed electric field system to treat skin cancerRichard Nuccitelli; Fiscal Year: 2008..It offers a scar-free alternative to surgery that could improve the quality of life for tens of thousands of dermatology patients. [unreadable] [unreadable] [unreadable]..
- VITAMIN D AND THE DIFFERENTIATION OF KERATINOCYTESDaniel Bikle; Fiscal Year: 2003..abstract_text> ..
- Development of an electrical diagnostic for melanomaRichard Nuccitelli; Fiscal Year: 2008..If the handheld BFI is able to reliably detect malignant skin lesions, it will improve the quality of life for tens of thousands of dermatology patients in the United States alone. [unreadable] [unreadable] [unreadable]..
- B-Vitamin Intake and Blood Pressure: The INTERMAP StudyLinda Van Horn; Fiscal Year: 2003..abstract_text> ..
- RASSF1 Tumor Suppressor GeneGERD PFEIFER; Fiscal Year: 2005..The effect of RASSF1 expression on RAS signaling pathways will be studied. We will examine if RASSF1A, alone or in combination with activated RAS, induces cell death (apoptosis). ..
- DNA methylation in cancer genomesGERD PFEIFER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- REGULATION OF INTESTINAL CALCIUM TRANSPORT BY VITAMIN DDaniel Bikle; Fiscal Year: 2001..These manipulations will all be tested for their ability to block 1,25D-stimulated calcium transport. ..
- DNA Replication Termination in Escherichia coli.CHARMAIN COURCELLE; Fiscal Year: 2005..These experiments are necessary to characterize this critical, yet heretofore unexamined, mechanism for accurate chromosomal replication. ..
- Ultraviolet B irradiation of human keratinocytesDan Spandau; Fiscal Year: 2004..Through the identification of these components of the UVB-response in human keratinocytes, therapeutic strategies for the prevention of LTVB-induced carcinogenesis can be developed. ..
- Fluoride Agents: Pattern of their Effect on Early CariesBennett Amaechi; Fiscal Year: 2005..QLF data will be matched with their corresponding TMR data to determine the QLF parameters for lesions that were either completely remineralized or only arrested. ..
- The Risk of Cancer in Fanconi Anemia HeterozygotesMarianne Berwick; Fiscal Year: 2005..Analyses will be undertaken to evaluate the role of Fanconi anemia heterozygosity for cancer. If carriers are found to be at increased risk, this information can be used to target individuals for cancer prevention strategies. ..
- Solar Exposure and Melanoma SurvivalMarianne Berwick; Fiscal Year: 2009..2. Determine whether functional polymorphic variants in the vitamin D receptor affect survival from melanoma. 3. Investigate the interaction of lifetime solar exposure and polymorphisms in VDR and its effect on survival. ..
- NUTRITION ACADEMIC AWARDLinda Van Horn; Fiscal Year: 2002..The generalizability of this model with potentially collaborative research opportunities with other medical schools in testing some of these strategies are further addressed. ..
- Effects of Formamidopyrimidine Lesions on DNAMarc Greenberg; Fiscal Year: 2006..abstract_text> ..
- Vision Research Infrastructure Development Grant (R24)FRANK GIBLIN; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- UV DAMAGE, REPAIR AND MUTAGENESISGERD PFEIFER; Fiscal Year: 2003..abstract_text> ..
- PROGRESSION OF NUCLEAR DENSITY OVER A 10-YEAR INTERVALBarbara Klein; Fiscal Year: 2002....
- Biosynthesis of Hypotensive Phosphonopeptide Natural ProductsBrian O Bachmann; Fiscal Year: 2010..Metalloproteinase inhibitors have potential to treat a large number of human illnesses including hypertension, cancer and osteoarthritis, among others. ..
- Epidermal Mechanisms Opposing Ceramide-Induced ApoptosisYoshikazu Uchida; Fiscal Year: 2009....
- Family Clustering of Incidence & Progression of CataractBarbara Klein; Fiscal Year: 2003..We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework. ..
- Linkage Studies of Quantitative Ocular TraitsBarbara Klein; Fiscal Year: 2006..Subsequent follow-up with fine mapping of areas of interest in the genome is planned. ..
- VITAMIN K AND BONE TURNOVER IN POSTMENOPAUSAL WOMENNeil Binkley; Fiscal Year: 2003..abstract_text> ..
- G2 CHECKPOINT FUNCTION IN HUMAN FIBROBLASTSWilliam Kaufmann; Fiscal Year: 2007..following DNA replication? Does ATR sends a signal through BRCA1 to inhibit Plkl when chromatid catenations are sensed? Is defective decatenation checkpoint function associated with genetic instability in cancer? ..
- Gonococcal Pilus Structure and FunctionH Seifert; Fiscal Year: 2008..These studies will provide new findings and insights into the structure and functions of the gonococcal pilus. ..
- Profiles of Sucsceptibility to Toxicant StressWilliam Kaufmann; Fiscal Year: 2007..The UNC-CH toxicogenomics research program has the scientific expertise and organizational infrastructure to provide significant and substantial benefits to the Toxicogenomics Research Consortium. ..
- THE ROLE OF RETINOIDS IN LACRIMAL GLAND FUNCTIONJohn Ubels; Fiscal Year: 2002..abstract_text> ..
- EARLY RESPONSE OF CORNEAL EPITHELIUM TO UV-INDUCED DEATHLuo Lu; Fiscal Year: 2004..Furthermore therapeutic measures may be identified which could reduce the incidence of UV-induced apoptotic corneal epithelial damage and increases in corneal epithelial susceptibility to infection and diseases. ..
- NEW STRATEGIES FOR NEOCORTICAL EPILEPSYSteven Rothman; Fiscal Year: 2007..If Peltier devices can control focal seizures in our models, they will be refined for future experiments to investigate their potential role in mapping and controlling epileptogenic neocortex in man. [unreadable] [unreadable]..
- S Checkpoint Function in Human FibroblastsWilliam Kaufmann; Fiscal Year: 2004..This project will define genetic components of the S checkpoint and elucidate signal transduction mechanisms that underlie S checkpoint response in diploid human fibroblasts. ..
- Confocal line-scanning versus point-scanning for imaging human skin in vivoMilind Rajadhyaksha; Fiscal Year: 2009..The diagnosis or surgical guidance may be noninvasive, with minimal need for biopsy, minimal pain and minimal expense. ..