infrared rays

Summary

Summary: That portion of the electromagnetic spectrum usually sensed as heat. Infrared wavelengths are longer than those of visible light, extending into the microwave frequencies. They are used therapeutically as heat, and also to warm food in restaurants.

Top Publications

  1. pmc Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
    L R Hirsch
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, USA
    Proc Natl Acad Sci U S A 100:13549-54. 2003
  2. ncbi In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
    R Weissleder
    Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Nat Biotechnol 17:375-8. 1999
  3. pmc Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation
    Sylvain Gioux
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Imaging 9:237-55. 2010
  4. pmc Neuroprotective effects of near-infrared light in an in vivo model of mitochondrial optic neuropathy
    Julio C Rojas
    Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 28:13511-21. 2008
  5. pmc Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction
    Nadine Wong Shi Kam
    Department of Chemistry and Laboratory for Advanced Materials, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:11600-5. 2005
  6. ncbi Multiphoton microscopy in life sciences
    K Konig
    Laser Microscopy Division, Institute of Anatomy II, Friedrich Schiller University, D 07740 Jena, Germany
    J Microsc 200:83-104. 2000
  7. ncbi Primary and secondary mechanisms of action of visible to near-IR radiation on cells
    T Karu
    Laser Technology Research Center of Russian Academy of Sciences, Troitsk, Moscow Region, Russia
    J Photochem Photobiol B 49:1-17. 1999
  8. ncbi Effect of NASA light-emitting diode irradiation on wound healing
    H T Whelan
    Department of Neurology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Clin Laser Med Surg 19:305-14. 2001
  9. ncbi Near infrared light reduces oxidative stress and preserves function in CNS tissue vulnerable to secondary degeneration following partial transection of the optic nerve
    Melinda Fitzgerald
    Experimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Western Australia, Australia
    J Neurotrauma 27:2107-19. 2010
  10. ncbi Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase
    Margaret T T Wong-Riley
    Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 280:4761-71. 2005

Research Grants

  1. NIR-LED Treatment for Parkinson's Disease
    HARRY WHELAN; Fiscal Year: 2007
  2. ADVANCES IN OPTICS FOR BIOTECHNOLOGY, MEDICINE
    Vasilis Ntziachristos; Fiscal Year: 2005
  3. Hybrid optical-ultrasound scanner for cancer imaging
    Vasilis Ntziachristos; Fiscal Year: 2005
  4. Nanoparticle-Based Optical Sensor for Glucose Monitoring
    Ralph Ballerstadt; Fiscal Year: 2006
  5. Smart Wheelchair Component System
    Edmund Lopresti; Fiscal Year: 2007
  6. INTEGRATED PLATFORM FOR CHEMICAL ANALYSIS OF LIVE CELLS
    Michael Berns; Fiscal Year: 2003
  7. Navigation Assistant for a Wheeled Walker
    Edmund Lopresti; Fiscal Year: 2005
  8. Digital Ultrasound Instrument
    DOUG WHALEN; Fiscal Year: 2004
  9. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2007
  10. 5-Day Fiber-Coupled Sensor Interstitial Glucose
    Ralph Ballerstadt; Fiscal Year: 2006

Detail Information

Publications305 found, 100 shown here

  1. pmc Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
    L R Hirsch
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, USA
    Proc Natl Acad Sci U S A 100:13549-54. 2003
    ..Tissues heated above the thermal damage threshold displayed coagulation, cell shrinkage, and loss of nuclear staining, which are indicators of irreversible thermal damage. Control tissues appeared undamaged...
  2. ncbi In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
    R Weissleder
    Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Nat Biotechnol 17:375-8. 1999
    ..In vivo imaging showed a 12-fold increase in NIRF signal, allowing the detection of tumors with submillimeter-sized diameters. This strategy can be used to detect such early stage tumors in vivo and to probe for specific enzyme activity...
  3. pmc Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation
    Sylvain Gioux
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Imaging 9:237-55. 2010
    ..Finally, we introduce state-of-the-art optical imaging techniques that might someday improve image-guided surgery even further...
  4. pmc Neuroprotective effects of near-infrared light in an in vivo model of mitochondrial optic neuropathy
    Julio C Rojas
    Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 28:13511-21. 2008
    ..The results show that NIL treatment can effectively prevent the neurotoxic effects of rotenone and that it might be used in the treatment of neurodegenerative disorders associated with mitochondrial dysfunction...
  5. pmc Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction
    Nadine Wong Shi Kam
    Department of Chemistry and Laboratory for Advanced Materials, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:11600-5. 2005
    ..Thus, the transporting capabilities of carbon nanotubes combined with suitable functionalization chemistry and their intrinsic optical properties can lead to new classes of novel nanomaterials for drug delivery and cancer therapy...
  6. ncbi Multiphoton microscopy in life sciences
    K Konig
    Laser Microscopy Division, Institute of Anatomy II, Friedrich Schiller University, D 07740 Jena, Germany
    J Microsc 200:83-104. 2000
    ..Moreover, cells remain alive. Non-invasive NIR laser surgery within a living cell or within an organelle is therefore possible...
  7. ncbi Primary and secondary mechanisms of action of visible to near-IR radiation on cells
    T Karu
    Laser Technology Research Center of Russian Academy of Sciences, Troitsk, Moscow Region, Russia
    J Photochem Photobiol B 49:1-17. 1999
    ..A cascade of reactions connected with alteration in cellular homeostasis parameters (pHi, [Cai], cAMP, Eh, [ATP] and some others) is considered as a photosignal transduction and amplification chain in a cell (secondary mechanisms)...
  8. ncbi Effect of NASA light-emitting diode irradiation on wound healing
    H T Whelan
    Department of Neurology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Clin Laser Med Surg 19:305-14. 2001
    ..This work is supported and managed through the NASA Marshall Space Flight Center-SBIR Program...
  9. ncbi Near infrared light reduces oxidative stress and preserves function in CNS tissue vulnerable to secondary degeneration following partial transection of the optic nerve
    Melinda Fitzgerald
    Experimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Western Australia, Australia
    J Neurotrauma 27:2107-19. 2010
    ..To our knowledge, this is the first demonstration that 670-nm NIR light can reduce oxidative stress and improve function in the CNS following traumatic injury in vivo...
  10. ncbi Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase
    Margaret T T Wong-Riley
    Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 280:4761-71. 2005
    ..The results are consistent with our hypothesis that the mechanism of photobiomodulation involves the up-regulation of cytochrome c oxidase, leading to increased energy metabolism in neurons functionally inactivated by toxins...
  11. ncbi Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging
    Vasilis Ntziachristos
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street 5406, Charlestown MA 02129 2060, USA
    Eur Radiol 13:195-208. 2003
    ..We describe theoretical specifics, and we provide insight into its in vivo capacity and the sensitivity achieved. Finally, we discuss its clinical feasibility...
  12. ncbi Photobiomodulation protects the retina from light-induced photoreceptor degeneration
    Rizalyn Albarracin
    Research School of Biology, National University, Canberra, Australia
    Invest Ophthalmol Vis Sci 52:3582-92. 2011
    ..In this study, the hypothesis that near-infrared (NIR) light treatment (photobiomodulation) attenuates bright-light damage in the albino rat retina was tested...
  13. ncbi Real-time handheld multispectral optoacoustic imaging
    Andreas Buehler
    Institute for Biological and Medical Imaging, Helmholtz Zentrum Munchen, Neuherberg 85764, Germany
    Opt Lett 38:1404-6. 2013
    ..In this Letter, we demonstrate its clinical potential by dynamically resolving multiple disease-relevant tissue chromophores, including oxy-/deoxyhemoglobin, and melanin, in human volunteers...
  14. ncbi Controlled-release system of single-stranded DNA triggered by the photothermal effect of gold nanorods and its in vivo application
    Shuji Yamashita
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi ku, Fukuoka 819 0395, Japan
    Bioorg Med Chem 19:2130-5. 2011
    ..Such a controlled-release system of oligonucleotide triggered by the photothermal effect could expand the applications of gold nanorods that have unique optical characteristics in medicinal fields...
  15. pmc Therapeutic photobiomodulation for methanol-induced retinal toxicity
    J T Eells
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 100:3439-44. 2003
    ..They also suggest that photobiomodulation may enhance recovery from retinal injury and other ocular diseases in which mitochondrial dysfunction is postulated to play a role...
  16. ncbi A library of IR bands of nucleic acids in solution
    Martina Banyay
    Department of Biochemistry and Biophysics, Arrhenius Laboratories, Stockholm University, S 106 91, Stockholm, Sweden
    Biophys Chem 104:477-88. 2003
    ..also concerns some recent results, where IR spectroscopy has been used to obtain semi-quantitative information on coexisting modes of sugar pucker in oligonucleotides...
  17. ncbi High-throughput AFLP analysis using infrared dye-labeled primers and an automated DNA sequencer
    A A Myburg
    Forest Biotechnology Group, Box 7247, Centennial Campus, North Carolina State University, Raleigh, NC 27695, USA
    Biotechniques 30:348-52, 354, 356-7. 2001
    ..Throughput is enhanced by using high-quality genomic DNA templates obtained by a 96-well DNA isolation procedure...
  18. ncbi Application of infrared laser to the zebrafish vascular system: gene induction, tracing, and ablation of single endothelial cells
    Eiji Kimura
    Department of Anatomy, Iwate Medical University, Iwate, Japan
    Arterioscler Thromb Vasc Biol 33:1264-70. 2013
    ..We applied this method to the vascular system in zebrafish embryos and demonstrated its usability to investigate mechanisms of vascular morphogenesis in vivo...
  19. pmc Optical cochlear implants: evaluation of surgical approach and laser parameters in cats
    Suhrud M Rajguru
    Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Hear Res 269:102-11. 2010
    ..Combined with histological data, the results suggest that pulsed IR stimulation does not lead to detectable acute tissue damage and validate the stimulation parameters that can be used in future chronic implants based on pulsed IR...
  20. ncbi Effect of 830 nm low-level laser therapy in exercise-induced skeletal muscle fatigue in humans
    Ernesto Cesar Pinto Leal Junior
    Laboratory of Human Movement LMH, University of Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul, 95070 560, Rio Grande do Sul, Brazil
    Lasers Med Sci 24:425-31. 2009
    ..We concluded that 830 nm LLLT can delay the onset of skeletal muscle fatigue in high-intensity exercises, in spite of increased blood lactate levels...
  21. ncbi Biological effect of far-infrared therapy on increasing skin microcirculation in rats
    Shi Yau Yu
    Institute of Molecular and Cellular Biology, Department of Life Science, National Tsing Hua University, Hsinchu, and Division of General Surgery, Department of Surgery, Veterans General Hospital, Taipei, Taiwan
    Photodermatol Photoimmunol Photomed 22:78-86. 2006
    ..Nevertheless, the mechanisms through which FIR works remain unclear. The present study aims to test the hypothesis that the effect of FIR is through increasing skin microcirculation by a mechanism other than its thermal effect...
  22. pmc Rapid temperature jump by infrared diode laser irradiation for patch-clamp studies
    Jing Yao
    Department of Physiology and Biophysical Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Biophys J 96:3611-9. 2009
    ....
  23. ncbi Effects of the Valsalva maneuver on pial artery pulsation and subarachnoid width in healthy adults
    Magdalena Wszedybyl-Winklewska
    Institute of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Tuwima Str 15, 80 210 Gdansk, Poland
    Microvasc Res 82:369-73. 2011
    ....
  24. ncbi Fluorescence quantum yields of a series of red and near-infrared dyes emitting at 600-1000 nm
    Knut Rurack
    Division 1 5 Bioanalytics, BAM Bundesanstalt für Materialforschung und prüfung, Berlin, Germany
    Anal Chem 83:1232-42. 2011
    ..In addition, the effects of temperature and the presence of oxygen on the fluorescence quantum yield of Rh-101 have been assessed...
  25. ncbi Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1)
    Yair Lampl
    Wolfson Medical Center, Department of Neurology, Holon, Israel
    Stroke 38:1843-9. 2007
    ..The NeuroThera Laser System therapeutic approach involves use of infrared laser technology and has shown significant and sustained beneficial effects in animal models of ischemic stroke...
  26. ncbi American Gastroenterological Association technical review on the diagnosis and treatment of hemorrhoids
    Robert D Madoff
    University of Minnesota, Minneapolis, MN, USA
    Gastroenterology 126:1463-73. 2004
  27. pmc Fever detection in under 5 children in a tertiary health facility using the infrared tympanic thermometer in the oral mode
    Benedict O Edelu
    Department of Pediatrics, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu, Nigeria
    Ital J Pediatr 37:8. 2011
    ..The oral mercury-in-glass thermometer which has relatively good accuracy cannot be used in children less than 5 years because it requires their cooperation...
  28. pmc Pulsed laser versus electrical energy for peripheral nerve stimulation
    Jonathon Wells
    Vanderbilt University, Department of Biomedical Engineering, 5824 Stevenson Center, Nashville, TN 37235, United States
    J Neurosci Methods 163:326-37. 2007
    ..Thus, use of a pulsed laser exhibits distinct advantages when compared to standard electrical means for excitation of muscle potentials in the peripheral nerve in the research domain and possibly for clinical diagnostics in the future...
  29. ncbi Use of infrared thermal imaging to isolate Arabidopsis mutants defective in stomatal regulation
    Sylvain Merlot
    Institut des Sciences du Vegetal, Centre National de la Recherche Scientifique UPR2355, Avenue de la Terrasse, 91190 Gif sur Yvette, France
    Plant J 30:601-9. 2002
    ..Remarkably, ost1 and ost2 represent, to our knowledge, the first Arabidopsis mutations altering ABA responsiveness in stomata and not in seeds...
  30. ncbi Application of infrared light for in vivo neural stimulation
    Jonathon Wells
    Vanderbilt University, Department of Biomedical Engineering, Box 351631, Station B, Nashville, Tennessee 37235, USA
    J Biomed Opt 10:064003. 2005
    ..g., noncontact, spatial resolution, lack of stimulation artifact) over conventional electrical methods in diagnostic and therapeutic procedures in neuroscience, neurology, and neurosurgery...
  31. ncbi Detection of sentinel node in gastric cancer surgery by indocyanine green fluorescence imaging: comparison with infrared imaging
    Isao Miyashiro
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Ann Surg Oncol 15:1640-3. 2008
    ..This was a clinical exploration/feasibility study of a novel detection system for SN biopsy using indocyanine green (ICG) fluorescence imaging in gastric cancer surgery...
  32. pmc Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity
    H L Liang
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroscience 153:963-74. 2008
    ..These results strongly suggest that LED treatment may be therapeutic to neurons damaged by neurotoxins linked to Parkinson's disease by energizing the cells and increasing their viability...
  33. ncbi Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles
    D Patrick O'Neal
    Nanospectra Biosciences, Inc, 8285 El Rio Suite 130, Houston, TX 77054, USA
    Cancer Lett 209:171-6. 2004
    ..This simple, non-invasive procedure shows great promise as a technique for selective photo-thermal tumor ablation...
  34. ncbi Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population
    Reiko Arita
    Itoh Clinic, Saitama, Japan
    Ophthalmology 115:911-5. 2008
    ..To examine the morphologic changes in meibomian glands associated with aging and gender using a novel meibography system and to assess their relation with slit-lamp findings regarding eyelid and tear film function in a normal population...
  35. ncbi Cellular response to infrared radiation involves retrograde mitochondrial signaling
    Peter Schroeder
    Institut für Umweltmedizinische Forschung at the Heinrich Heine University Düsseldorf gGmbH, Auf m Hennekamp 50, D 40225 Duesseldorf, Germany
    Free Radic Biol Med 43:128-35. 2007
    ..Thus, IRA, in contrast to UV, elicits a retrograde signaling response in human skin...
  36. pmc Infrared light excites cells by changing their electrical capacitance
    Mikhail G Shapiro
    Department of Biochemistry and Molecular Biology, University of Chicago, 929 E 57th Street, GCIS W244, Illinois 60637, USA
    Nat Commun 3:736. 2012
    ..This mechanism is fully reversible and requires only the most basic properties of cell membranes. Our findings underscore the generality of pulsed infrared stimulation and its medical potential...
  37. ncbi Use of infrared thermography for monitoring stomatal closure in the field: application to grapevine
    Hamlyn G Jones
    Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, SCRI, Invergowrie, Dundee DD2 5DN, UK
    J Exp Bot 53:2249-60. 2002
    ..Evidence is presented that the temperature of reference surfaces exposed within the canopy can be affected by the canopy water status...
  38. ncbi Development of chitosan oligosaccharide-modified gold nanorods for in vivo targeted delivery and noninvasive imaging by NIR irradiation
    Shobhit Charan
    Research Center for Applied Sciences, Academia Sinica, Taipei 115, Taiwan
    Bioconjug Chem 23:2173-82. 2012
    ..Hence, the CO-GNRs that we have developed are biocompatible and nontoxic and can be a potential candidate for in vivo targeted delivery, noninvasive imaging based on localized hyperthermia, and photothermal-related therapies...
  39. pmc Noninvasive diagnosis of seed viability using infrared thermography
    Ilse Kranner
    Seed Conservation Department, Royal Botanic Gardens, Kew, Wakehurst Place, West Sussex RH17 6TN, UK
    Proc Natl Acad Sci U S A 107:3912-7. 2010
    ..We believe that the early separation of individual, ungerminated seeds (live, aged, or dead) before destructive germination assessment creates unique opportunities for integrative studies on cell death, differentiation, and development...
  40. pmc Intracellular calcium transients evoked by pulsed infrared radiation in neonatal cardiomyocytes
    Gregory M Dittami
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    J Physiol 589:1295-306. 2011
    ..Results support the hypothesis that 1862 nm pulsed IR modulates mitochondrial Ca2+ transport primarily through actions on mCU and mNCX...
  41. pmc Photo-oxidative killing of human colonic cancer cells using indocyanine green and infrared light
    W Baumler
    Department of Dermatology, University of Regensburg, Germany
    Br J Cancer 80:360-3. 1999
    ..Therefore, ICG might present a promising photosensitizer for PDT; first clinical results confirm these findings...
  42. ncbi Infrared imaging of meibomian gland structure using a novel keratograph
    Sruthi Srinivasan
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Optom Vis Sci 89:788-94. 2012
    ..To examine the ability of a novel non-contact device (Keratograph 4) to image the meibomian gland (MG) structures and their morphological changes in the upper and lower eyelids...
  43. ncbi Targetable gold nanorods for epithelial cancer therapy guided by near-IR absorption imaging
    Jihye Choi
    Department of Chemical and Bimolecular Engineering, Yonsei University, Seoul 120 749, Republic of Korea
    Small 8:746-53. 2012
    ..CET-PGNRs exhibit excellent tumor targeting ability and strong potential for simultaneous absorption imaging and photothermal ablation of epithelial cancer cells...
  44. ncbi Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson's disease
    Cassandra Peoples
    Discipline of Anatomy and Histology F13, University of Sydney, Australia
    Parkinsonism Relat Disord 18:469-76. 2012
    ..In summary, exposure to NIr either at the same time or well after chronic MPTP insult saved many SNc dopaminergic cells from degeneration...
  45. ncbi Excitation of primary afferent neurons by near-infrared light in vitro
    Elizabeth J Katz
    Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, Maryland 20993, USA
    Neuroreport 21:662-6. 2010
    ..9 mV) suggests that LED is unrelated to the activation of heat-sensitive transient receptor potential cation channel subfamily V member 1 channels. The long duration of LEDs favors an involvement of second messengers...
  46. pmc The effects inhibiting the proliferation of cancer cells by far-infrared radiation (FIR) are controlled by the basal expression level of heat shock protein (HSP) 70A
    Jun Ishibashi
    Department of Oral and Maxillofacial Anatomy, Medical Science for Oral and Maxillofacial Regeneration, Graduate School of Health Biosciences, University of Tokushima, 3 18 15 Kuramoto, Tokushima 770 8504, Japan
    Med Oncol 25:229-37. 2008
    ..Still more, if the level of HSP70 in any cancer of a patient was measured, the effect of medical treatment by FIR can be foreseen for the cancer...
  47. ncbi Infrared radiation confers resistance to UV-induced apoptosis via reduction of DNA damage and upregulation of antiapoptotic proteins
    Christian Jantschitsch
    Department of Dermatology, University Kiel, Kiel, Germany
    J Invest Dermatol 129:1271-9. 2009
    ..As, however, IR reduces UV-induced DNA damage, the balance between these two effects may be important. Thus, in vivo carcinogenesis studies are required to define the role of IR and its interaction with UV in photocarcinogenesis...
  48. ncbi Investigation of jewelry powders radiating far-infrared rays and the biological effects on human skin
    B H Yoo
    Skin Research Institute, Pacific Corp R and D Center, 314 1, Bora ri Kiheung eup, Yongin si, Kyounggi Do, Korea 449 900
    J Cosmet Sci 53:175-84. 2002
    Far-infrared rays have certain kinds of effects on the human body, especially on skin, blood circulation, and skin cell vitalizing. Some jewelry powders radiate far-infrared rays...
  49. pmc Wavelength-dependent conformational changes in collagen after mid-infrared laser ablation of cornea
    Yaowu Xiao
    Department of Physics and Astronomy, Vanderbilt Institute for Integrative Biosystem Research and Education, Vanderbilt University, Nashville, Tennessee 37235, USA
    Biophys J 94:1359-66. 2008
    ..45-microm debris. These results support the hypothesis that the favorable ablative properties of protein-targeting wavelengths rest on selective heating of tissue proteins...
  50. ncbi In vivo near-infrared fluorescence imaging of matrix metalloproteinase activity after cerebral ischemia
    Jan Klohs
    Department of Experimental Neurology, Center for Stroke Research Berlin, Charite University Medicine Berlin, Chariteplatz 1, Berlin 10117, Germany
    J Cereb Blood Flow Metab 29:1284-92. 2009
    ..Our study shows that MMP activity after cerebral ischemia can be imaged noninvasively with NIRF using an MMP-activatable probe, which might be a useful tool to study MMP activity in the pathophysiology of the disease...
  51. ncbi Photodynamic therapy of multiple actinic keratoses: reduced pain through use of visible light plus water-filtered infrared A compared with light from light-emitting diodes
    V von Felbert
    Department of Dermatology, RWTH Aachen University, 52074 Aachen, Germany
    Br J Dermatol 163:607-15. 2010
    ..Photodynamic therapy (PDT) with methyl aminolaevulinate (MAL) is an effective treatment for multiple actinic keratoses (AKs). Pain, however, is a major side-effect...
  52. ncbi Effect of NASA light-emitting diode irradiation on molecular changes for wound healing in diabetic mice
    Harry T Whelan
    Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Clin Laser Med Surg 21:67-74. 2003
    ..The purpose of this study was to assess the changes in gene expression of near-infrared light therapy in a model of impaired wound healing...
  53. ncbi Infrared exposure induces an angiogenic switch in human skin that is partially mediated by heat
    M S Kim
    Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul, Korea
    Br J Dermatol 155:1131-8. 2006
    ..Although acute ultraviolet-induced skin angiogenesis has been investigated, little is known about the distinct effects of acute infrared (IR) radiation on angiogenesis in human skin...
  54. ncbi Far-infrared radiation promotes angiogenesis in human microvascular endothelial cells via extracellular signal-regulated kinase activation
    Cheng Shyuan Rau
    Department of Neurosurgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Photochem Photobiol 87:441-6. 2011
    ..This study revealed that FIR radiation possesses in vitro angiogenic activity via the activation of the MEK/ERK but not the VEGF/Akt/eNOS-dependent signaling pathways...
  55. ncbi Limitations of forehead infrared body temperature detection for fever screening for severe acute respiratory syndrome
    Chuan Chuan Liu
    Department of Clinical Physiology, Mackay Memorial Hospital, Taipei, Taiwan
    Infect Control Hosp Epidemiol 25:1109-11. 2004
    ..Our results indicate that the auditory meatus temperature is a superior alternative compared with the forehead body surface temperature due to its close approximation to the tympanic temperature...
  56. ncbi Digital infrared thermal imaging of human skin
    B F Jones
    School of Computing and Technology, University of Derby
    IEEE Eng Med Biol Mag 21:41-8. 2002
  57. pmc Comparison of 3 infrared thermal detection systems and self-report for mass fever screening
    An V Nguyen
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 16:1710-7. 2010
    ..42) but significantly lower for Wahl (ρ = 0.14; p < 0.001). When compared with oral temperatures, 2 systems (OptoTherm and FLIR) were reasonably accurate for detecting fever and predicted fever better than self-reports...
  58. pmc An improved cell-penetrating, caspase-activatable, near-infrared fluorescent peptide for apoptosis imaging
    Dustin Maxwell
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, Missouri 63110, USA
    Bioconjug Chem 20:702-9. 2009
    ..Thus, KcapQ represents an improved effector caspase-activatable NIRF probe for enhanced noninvasive analysis of apoptosis in whole cells and live animals...
  59. ncbi Clinical and experimental applications of NIR-LED photobiomodulation
    Kristina D Desmet
    Department of Clinical Laboratory Sciences, University of Wisconsin Milwaukee, 53226, USA
    Photomed Laser Surg 24:121-8. 2006
    ..NIR-LED light represents a novel, noninvasive, therapeutic intervention for the treatment of numerous diseases linked to mitochondrial dysfunction...
  60. pmc Antibody-conjugated gold-gold sulfide nanoparticles as multifunctional agents for imaging and therapy of breast cancer
    Emily S Day
    Department of Bioengineering, Rice University, Houston, TX, USA
    Int J Nanomedicine 5:445-54. 2010
    ..GGS-NPs are ideal multifunctional agents for cancer management because they offer the ability to pinpoint precise treatment sites and perform subsequent thermal ablation in a single setting...
  61. pmc Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation
    Andrew Burke
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 106:12897-902. 2009
    ..These treatment parameters resulted in complete ablation of tumors and a >3.5-month durable remission in 80% of mice treated with 100 microg of MWCNT. Use of MWCNTs with NIR may be effective in anticancer therapy...
  62. ncbi Neuroprotection of midbrain dopaminergic cells in MPTP-treated mice after near-infrared light treatment
    Victoria E Shaw
    Discipline of Anatomy and Histology F13, University of Sydney, Australia
    J Comp Neurol 518:25-40. 2010
    ..In summary, our results indicate that NIr light treatment offers neuroprotection against MPTP toxicity for dopaminergic cells in the SNc, but not in the ZI-Hyp...
  63. ncbi Light-emitting diode treatment reverses the effect of TTX on cytochrome oxidase in neurons
    M T Wong-Riley
    Department of Cell Biology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroreport 12:3033-7. 2001
    ..LED alone also up-regulated enzyme activity. Thus, the results are consistent with our hypothesis that LED has a stimulating effect on cytochrome oxidase in neurons, even when they have been functionally silenced by TTX...
  64. ncbi Infrared laser-mediated local gene induction in medaka, zebrafish and Arabidopsis thaliana
    Tomonori Deguchi
    Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology, 3 11 46 Nakouji, Amagasaki, Hyogo, Japan
    Dev Growth Differ 51:769-75. 2009
    ..IR-LEGO has the potential to be a useful tool in extensive research fields for cell/tissue marking or targeted gene expression in local tissues of small fish and plants...
  65. pmc Remotely triggered liposome release by near-infrared light absorption via hollow gold nanoshells
    Guohui Wu
    Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA
    J Am Chem Soc 130:8175-7. 2008
    ..In addition, the capability of external HGNs to permeabilize lipid membranes can facilitate the cellular uptake of macromolecules including proteins and DNA and allow for promising applications in gene therapy...
  66. ncbi Effectiveness of a noninvasive digital infrared thermal imaging system in the detection of breast cancer
    Nimmi Arora
    Department of Surgery, New York Presbyterian Hospital Cornell, New York, NY, USA
    Am J Surg 196:523-6. 2008
    ..Digital infrared thermal imaging (DITI) has resurfaced in this era of modernized computer technology. Its role in the detection of breast cancer is evaluated...
  67. ncbi Near-infrared emitting fluorophore-doped calcium phosphate nanoparticles for in vivo imaging of human breast cancer
    Erhan I Altinoglu
    Department of Materials Science and Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    ACS Nano 2:2075-84. 2008
    ..Our ex vivo and in vivo experiments verify the promise of the NIR CPNPs for diagnostic imaging in the early detection of solid tumors...
  68. ncbi Fluorescence imaging in vivo: recent advances
    Jianghong Rao
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Cancer Biology Program, Stanford University School of Medicine, 1201 Welch Road, Stanford, California 94305 5484, USA
    Curr Opin Biotechnol 18:17-25. 2007
    ..Further emerging developments are aiming to achieve high-resolution, multimodality and lifetime-based in vivo fluorescence imaging...
  69. pmc Spatial temperature distribution in human hairy and glabrous skin after infrared CO2 laser radiation
    Ken S Frahm
    Center for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220 Aalborg, Denmark
    Biomed Eng Online 9:69. 2010
    ..The laser energy is absorbed by the water content in the most superficial layers of the skin. The deeper located nociceptors are activated by passive conduction of heat from superficial to deeper skin layers...
  70. ncbi Target tracking in infrared imagery using weighted composite reference function-based decision fusion
    Amer Dawoud
    Department of Electrical and Computer Engineering, The University of South Alabama, Mobile, AL 36688, USA
    IEEE Trans Image Process 15:404-10. 2006
    ..The results furnished by competing ego-motion compensation and tracking algorithms are evaluated based on their similarity to a target model constructed using the weighted composite reference function...
  71. pmc Infrared photostimulation of the crista ampullaris
    Suhrud M Rajguru
    Department of Otolaryngology, Northwestern University, Chicago, IL 60611, USA
    J Physiol 589:1283-94. 2011
    ..The present data support the hypothesis that pulsed IR activates sensory hair cells, thus leading to modulation of synaptic transmission and afferent nerve discharge reported here...
  72. pmc Acoustic events and "optophonic" cochlear responses induced by pulsed near-infrared laser
    Ingo Ulrik Teudt
    Institute of Audioneurotechnology, Hannover School of Medicine, Hannover, Germany
    IEEE Trans Biomed Eng 58:1648-55. 2011
    ..The present data demonstrate that laser-evoked acoustic events can stimulate a hearing cochlea. Whenever optical stimulation is used, care must be taken to distinguish between such "optophony" and the true optoneural response...
  73. ncbi Hand-held based near-infrared optical imaging devices: a review
    Sarah J Erickson
    Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, Miami, FL 33174, United States
    Med Eng Phys 31:495-509. 2009
    ....
  74. ncbi Usefulness of intraoperative fluorescence imaging to evaluate local anatomy in hepatobiliary surgery
    Noboru Mitsuhashi
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hepatobiliary Pancreat Surg 15:508-14. 2008
    ..We investigated the potential utility of an infrared camera system as a tool for evaluating local anatomy during hepatobiliary surgery...
  75. pmc Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism
    Rong Zhang
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53326, USA
    J Mol Cell Cardiol 46:4-14. 2009
    ..Taken together these data provide evidence for protection against hypoxia and reoxygenation injury in cardiomyocytes by NIR in a manner that is dependent upon NO derived from NOS and non-NOS sources...
  76. pmc Thermal ablation therapeutics based on CN(x) multi-walled nanotubes
    Suzy V Torti
    Department of Biochemistry, Wake Forest University Health Sciences, Winston Salem, NC 27109 7507, USA
    Int J Nanomedicine 2:707-14. 2007
    ..This cell death was attributed directly to photothermal effect generated within the culture, since neither the infrared irradiation itself nor the CN(x)-MWNT were toxic to the cells...
  77. ncbi Far-infrared therapy: a novel treatment to improve access blood flow and unassisted patency of arteriovenous fistula in hemodialysis patients
    Chih Ching Lin
    Division of Nephrology, Institute of Clinical Medicine and School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    J Am Soc Nephrol 18:985-92. 2007
    ..9 versus 67.6%; P < 0.01). In conclusion, FIR therapy, a noninvasive and convenient therapeutic modality, can improve Qa and survival of the AVF in HD patients through both its thermal and its nonthermal effects...
  78. ncbi Image-guided liver mapping using fluorescence navigation system with indocyanine green for anatomical hepatic resection
    Takeshi Aoki
    Department of General and Gastroenterological Surgery, School of Medicine, Showa University, Tokyo, Japan
    World J Surg 32:1763-7. 2008
    ..Our purpose was to develop an intraoperative method for identifying segment and subsegment of the liver with high-sensitivity near-infrared fluorescence imaging...
  79. pmc Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1
    Chih Ching Lin
    Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 28:739-45. 2008
    ..In this study, we evaluated whether there is an interaction between FIR radiation and HO-1 in regulating vascular inflammation...
  80. pmc Intraoperative near-infrared fluorescent cholangiography (NIRFC) in mouse models of bile duct injury
    Jose Luiz Figueiredo
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    World J Surg 34:336-43. 2010
    ....
  81. ncbi Feasibility study of particle-assisted laser ablation of brain tumors in orthotopic canine model
    Jon A Schwartz
    Nanospectra Biosciences, Inc, Houston, Texas 77054, USA
    Cancer Res 69:1659-67. 2009
    ..Postmortem histopathology of treated brain sections showed the effectiveness and selectivity of the nanoshell-assisted thermal ablation...
  82. ncbi A novel mitochondrial signaling pathway activated by visible-to-near infrared radiation
    Tiina I Karu
    Institute of Laser and Information Technologies of the Russian Academy of Sciences, Troitsk, Moscow Region, Russian Federation
    Photochem Photobiol 80:366-72. 2004
    ....
  83. ncbi Near infrared laser-tissue welding using nanoshells as an exogenous absorber
    Andre M Gobin
    Department of Bioengineering, Rice University, 6100 S Main Street, Houston, TX 77251, USA
    Lasers Surg Med 37:123-9. 2005
    ..In these studies, we have investigated the use of gold nanoshells as exogenous NIR absorbers to facilitate NIR laser-tissue welding...
  84. ncbi Visual evoked potentials to infrared stimulation in normal cats and rats
    M T Pardue
    Research Service, Hines VA Hospital, IL, USA
    Doc Ophthalmol 103:155-62. 2001
    ..However, these results should be interpreted with caution since here we report an unappreciated sensitivity of the native retina to infrared light under dark-adapted conditions...
  85. ncbi Visual prey detection by near-infrared cues in a fish
    Denis Meuthen
    Institute for Evolutionary Biology and Ecology, University of Bonn, An der Immenburg 1, 53121, Bonn, Germany
    Naturwissenschaften 99:1063-6. 2012
    ..These results give first evidence for NIR visual sensitivity in a functional context and thus challenge the current view about NIR perception...
  86. ncbi An assessment of grading scales for meibography images
    Jason J Nichols
    The Ohio State University, Columbus, 43218, USA
    Cornea 24:382-8. 2005
    ..To evaluate the within- and between-reader reliability and the interrelation between 2 methods of grading meibography images...
  87. pmc EphrinA I-targeted nanoshells for photothermal ablation of prostate cancer cells
    Andre M Gobin
    Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
    Int J Nanomedicine 3:351-8. 2008
    ..We demonstrate selective photo-thermal destruction of these cells upon application of the NIR laser...
  88. ncbi Morphological evaluation of meibomian glands using noncontact infrared meibography
    Yumiko Ban
    Department of Ophthalmology, Tokyo Dental College, School of Dental Medicine, Chiba, Japan
    Ocul Surf 11:47-53. 2013
    ..The mean length of the male's MG ducts in the lower eyelid was significantly longer than that of the females (P=.03). These results indicate that morphometric analysis using NIM may be useful for assessing ocular surface conditions...
  89. pmc Kinetics of a collagen-like polypeptide fragmentation after mid-IR free-electron laser ablation
    Andrey Zavalin
    Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235, USA
    Biophys J 95:1371-81. 2008
    ....
  90. pmc An overview of recent application of medical infrared thermography in sports medicine in Austria
    Carolin Hildebrandt
    Department of Sport Science, University of Innsbruck, Fuerstenweg 185, A 6020 Innsbruck, Austria
    Sensors (Basel) 10:4700-15. 2010
    ..It is concluded that MIT is a non-invasive, non-radiating, low cost detection tool which should be applied for pre-scanning athletes in sports medicine...
  91. ncbi Effect of visible and infrared polarized light on the healing process of full-thickness skin wounds: an experimental study
    Panagiota Iordanou
    Technological Educational Institute of Athens, Ioannina University School of Medicine, Ioannina, Greece
    Photomed Laser Surg 27:261-7. 2009
    ..The aim of this study was to evaluate the effect of visible and infrared polarized light of a specific range of wavelength (580-3400 nm) on the secondary healing of full-thickness skin wounds in rats...
  92. ncbi Experimental basis for discriminating between thermal and athermal effects of water-filtered infrared A irradiation
    Tobias Jung
    Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany
    Ann N Y Acad Sci 1259:33-8. 2012
    ..In the following, we discuss different experimental setups and highlight some cellular responses to thermal and athermal wIRA effects, as well as the experimental problems in differentiating between them...
  93. ncbi [Theragnostic approaches using gold nanorods and near infrared light]
    Takuro Niidome
    Faculty of Engineering, Kyushu University, Fukuoka, Japan
    Yakugaku Zasshi 130:1671-7. 2010
    ..The gold nanorods therefore showed several functions as a photothermal nanodevice for bioimaging, thermal therapy, and a drug delivery system...
  94. pmc Molecular basis of infrared detection by snakes
    Elena O Gracheva
    Department of Physiology, University of California, San Francisco, California 94158 2517, USA
    Nature 464:1006-11. 2010
    ..These findings illustrate the broad evolutionary tuning of transient receptor potential (TRP) channels as thermosensors in the vertebrate nervous system...
  95. ncbi Structure of interacting segments in the growing amyloid fibril of beta2-microglobulin probed with IR spectroscopy
    Ming Lu
    Department of Photoscience, School of Advanced Studies, The Graduate University for Advanced Studies, Shonan Village, Hayama, Kanagawa, 240 0193, Japan
    J Mol Biol 362:355-64. 2006
    ..This is consistent with the different protonation levels of these regions, and the direction of peptide in the fibrils is determined from these results...
  96. ncbi Effects of water-filtered infrared A irradiation on human fibroblasts
    Tobias Jung
    Institute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstrasse 28, 70593 Stuttgart, Germany
    Free Radic Biol Med 48:153-60. 2010
    ..Further experiments revealed that the major absorbance of infrared is due to absorption of the energy by cellular water...
  97. pmc Intraoperative localization of insulinoma and normal pancreas using invisible near-infrared fluorescent light
    Joshua H Winer
    Department of Surgery, Brigham and Women s Hospital, Boston, MA, USA
    Ann Surg Oncol 17:1094-100. 2010
    ..Our hypothesis is that a near-infrared (NIR) fluorophore exhibiting uptake in insulinoma could provide high-sensitivity detection intraoperatively...
  98. ncbi Linear polarized infrared irradiation using Super Lizer is an effective treatment for multiple-type alopecia areata
    Masashi Yamazaki
    Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan
    Int J Dermatol 42:738-40. 2003
    ..Super Lizer trade mark is a linear polarized light instrument, which has been used with good effect in orthopedics and anesthesiology to treat arthralgia and neuralgia with a high output of infrared radiation...
  99. pmc Spread of cochlear excitation during stimulation with pulsed infrared radiation: inferior colliculus measurements
    C P Richter
    Department of Otolaryngology, Northwestern University, Chicago, IL 60611, USA
    J Neural Eng 8:056006. 2011
    ..The majority of ICC STCs indicated that the spread of activation evoked by optical stimuli is comparable to that produced by acoustic tone pips...
  100. ncbi Effect of linear polarized near-infrared light irradiation on flexibility of shoulder and ankle joints
    S Demura
    Department of Physical Education, Kanazawa University, Kanazawa, Japan
    J Sports Med Phys Fitness 42:438-45. 2002
    ..The purpose of this study was to examine the influence of PL-irradiation on the ranges of shoulder and ankle motions...
  101. ncbi Changes in sensory and pain perception thresholds after linear polarized near-infrared light radiation in the trigeminal region
    Koji Kashima
    Department of Oral and Maxillofacial Surgery, Miyazaki Medical College, Hyotake cho, Miyazaki, Japan
    Cranio 23:174-8. 2005
    ....

Research Grants67

  1. NIR-LED Treatment for Parkinson's Disease
    HARRY WHELAN; Fiscal Year: 2007
    ....
  2. ADVANCES IN OPTICS FOR BIOTECHNOLOGY, MEDICINE
    Vasilis Ntziachristos; Fiscal Year: 2005
    ..Aim 4: To promote interaction between the invited scientists and participating students, to support education and understanding of the multi-disciplinary field of bio-optics and associated applications and to enable collaborations. ..
  3. Hybrid optical-ultrasound scanner for cancer imaging
    Vasilis Ntziachristos; Fiscal Year: 2005
    ..abstract_text> ..
  4. Nanoparticle-Based Optical Sensor for Glucose Monitoring
    Ralph Ballerstadt; Fiscal Year: 2006
    ..abstract_text> ..
  5. Smart Wheelchair Component System
    Edmund Lopresti; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  6. INTEGRATED PLATFORM FOR CHEMICAL ANALYSIS OF LIVE CELLS
    Michael Berns; Fiscal Year: 2003
    ..The achievement of the technological objectives interfaced into one platform will provide an enabling technology with a wide variety of applications in molecular medicine and biomedical research. ..
  7. Navigation Assistant for a Wheeled Walker
    Edmund Lopresti; Fiscal Year: 2005
    ..Phase II activities will include refining the prototype, implementing software for analyzing the activity level of the user, and testing the system extensively with potential users. ..
  8. Digital Ultrasound Instrument
    DOUG WHALEN; Fiscal Year: 2004
    ..A collection of Matlab applications will allow us to quantify the images collected by the instrument. ..
  9. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2007
    ..In addition, transgenic mice lacking PACAP and VIP will be analyzed with behavioral and anatomical tools. These newly developed mice are likely to prove a useful tool for circadian rhythms research. ..
  10. 5-Day Fiber-Coupled Sensor Interstitial Glucose
    Ralph Ballerstadt; Fiscal Year: 2006
    ..We believe the proposed sensor can provide a solution for short-term (3-5 days) continuous monitoring that will be accurate, reliable, and convenient for patient use. [unreadable] [unreadable] [unreadable]..
  11. Focusing Differential Mobility Analyzer
    VICTOR LAIKO; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  12. Cortical Plasticity after Hemispherectomy
    Gary Mathern; Fiscal Year: 2006
    ..abstract_text> ..
  13. Cidofovir for Perianal Dysplasia in HIV Patients
    Elizabeth Stier; Fiscal Year: 2006
    ..Novel treatments, such as topical cidofovir, may prevent pre-cancerous lesions from developing into cancer in HIV-infected patients. ..
  14. REGULATION OF THE MAMMALIAN CIRCADIAN SYSTEM
    Christopher Colwell; Fiscal Year: 2002
    ..Finally, the proposed work will determine whether a model developed to explain synchronization of molluscan circadian oscillators can be applied to the mammalian SCN. ..
  15. The Contact Lens and Dry Eye Study
    Jason Nichols; Fiscal Year: 2006
    ..The long-term objective of this research is to contribute to a better understanding of the etiology and risk factors for contact lens-related dry eye so that progress can be made toward its prevention. ..
  16. METABOLIC ORGANIZATION & REGULATION IN THE VISUAL CORTEX
    Margaret Wong Riley; Fiscal Year: 2002
    ..Results from these studies are expected to provide insight into the molecular basis of metabolic responses of visual cortical neurons to changing functional demands. ..
  17. REAL-TIME MICROSCOPIC IMAGING OF FAST MEMBRANE POTENTIA
    VLADISLAV YAKOVLEV; Fiscal Year: 2002
    ..Optical microscopy could lead to new diagnostic methods and a better understanding of the mechanisms of disease progression. ..
  18. Hearing Aid Connectivity to Consumer Electronics
    DANIEL HEDIN; Fiscal Year: 2008
    ..These individuals have a reduced ability to hear in acoustically noisy environments. [unreadable] [unreadable] [unreadable]..
  19. Compact Line-scanning Adaptive Optics Retinal Imager
    Daniel Hammer; Fiscal Year: 2007
    ..These researchers will, in turn, use this tool to increase our understanding of vision and its disruption by disease and for the development of new drugs and therapies. [unreadable] [unreadable] [unreadable]..
  20. NON-INVASIVE OPTICAL IMAGING OF THE HUMAN BRAIN
    MARIA FRANCESCHINI; Fiscal Year: 2002
    ..abstract_text> ..
  21. A role for circadian clock genes in hippocampal function?
    Christopher Colwell; Fiscal Year: 2008
    ..This line of research has not been previously funded, is exploratory in nature, and thus qualifies under the R21 format. [unreadable] [unreadable] [unreadable]..
  22. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2001
    ..abstract_text> ..
  23. Home Pediatric Critical Care Intervention to Reduce Hospitalization
    DANIEL HEDIN; Fiscal Year: 2007
    ..Early intervention may mitigate against the development of more severe illness that would likely require inpatient hospital care in a pediatric intensive care unit (PICU). [unreadable] [unreadable] [unreadable] [unreadable]..
  24. Quantification of Drusen in Macular Degeneration
    Thomas Friberg; Fiscal Year: 2003
    ..That is, such continuous quantitative data may, when analyzed, provide a more accurate and sensitive assessment of risk compared to conventional measurement techniques. ..
  25. Temperature & Vasomotor Tone During the First 5 Days in Preterms Less than 1000g
    ROBIN BRITT KNOBEL; Fiscal Year: 2010
    ....
  26. Neurochemical Organization of Brain Stem Respiratory Nuclei
    MARGARET TT WONG RILEY; Fiscal Year: 2010
    ....
  27. Wireless Digital Link Between Hearing Aids
    DANIEL HEDIN; Fiscal Year: 2006
    ..These results will allow us to develop antenna structures suitable for hearing aids that are in close proximity to the body. [unreadable] [unreadable] [unreadable]..
  28. GUANYLYL CYCLASE C AS A BI0MARKER FOR COLORECTAL CANCER
    Scott Waldman; Fiscal Year: 2006
    ....
  29. Interstitial Drug Delivery to Thermoablated Liver Tumors
    Jinming Gao; Fiscal Year: 2005
    ..In combination with image-guided thermoablation, this therapeutic procedure should provide an innovative, minimally invasive and less toxic therapy for the treatment of liver tumors. ..
  30. Micellar Nanotherapeutics for Targeted Lung Cancer Therapy
    Jinming Gao; Fiscal Year: 2010
    ..If successfully established, these micelles will provide a powerful nanomedicine platform that will impact the translation of novel molecular targets of lung cancer in clinical therapy. ..
  31. Novel Optical Coherence Holographic Imaging
    Nasser Peyghambarian; Fiscal Year: 2006
    ..3 lines per mm below 100 micron of medium with a scattering coefficient of 100 cm^-1. Successful completion of this project will include the design a specific medical/clinical application suitable for a R33 phase. ..
  32. Photothermal Imaging of Live Cells
    Vladimir Zharov; Fiscal Year: 2008
    ..The technical realization of PTI is relatively simple, requiring the combination of conventional optical phase-contrast microscopy and the already routinely used nanosecond laser. ..
  33. Integrated Photothermal Nanoprobes
    Vladimir Zharov; Fiscal Year: 2007
    ..The results of these studies will also make it possible to formulate recommendations on the desired properties of new, clustered nanomaterials for medical applications. [unreadable] [unreadable] [unreadable]..
  34. LCDIO FOR LYMPH NODE MR IMAGING
    Ralph Weissleder; Fiscal Year: 2001
    ..abstract_text> ..
  35. IMAGING APOPTOSIS IN VIVO WITH TECHNETIUM 99M ANNEXIN
    Francis Blankenberg; Fiscal Year: 2007
    ..Completion of this proposal will aid in the design and planning of clinical trials that will study the use of serial annexin V imaging as a non-invasive marker of cellular injury and therapeutic efficacy. ..
  36. Breast Tissue ablation by Conductive Heating
    Gal Shafirstein; Fiscal Year: 2007
    ..It can also be applied, through further research, to other types of cancers (e.g. lung, kidney, head and neck) that involve surgical resection of solid tumors. [unreadable] [unreadable] [unreadable]..
  37. Smart Power Assistance Module for Manual Wheelchairs
    Edmund Lopresti; Fiscal Year: 2003
    ..Extensive outside evaluation of the SPAM will be provided throughout the course of the project by clinicians active in wheelchair seating and mobility. ..
  38. Real-Time Three-Dimensional Motion Control Tracker
    Daniel Hammer; Fiscal Year: 2003
    ..After optimization, the Phase II instrument will be tested in a clinical ophthalmic program and the improvement in measurement of retinal features (e.g., nerve fiber layer thickness) will be quantified. ..
  39. HIGH EFFICIENCY LYMPHOCYTE LABELING FOR IN VIVO TRACKING
    Ralph Weissleder; Fiscal Year: 2004
    ..Furthermore, the investigators believe that the proposed research is in the widest interest to the current NIAID program and other research programs in further developing robust tools to track immune cells in vivo. ..
  40. ADAPTING NAGCAT FOR ETHNIC COMMUNITIES : A RESEARCH MODE
    JOHN SHUTSKE; Fiscal Year: 2002
    ....
  41. TRAINING PROGRAM IN HUMAN INVESTIGATION
    Scott Waldman; Fiscal Year: 2004
    ..Upon completion of the program, trainees will be qualified to perform independent clinical research with certification through a Master's of Science in Human Investigation. ..
  42. Stabilized Adaptive Optics Imaging Laser Microsurgery
    Daniel Hammer; Fiscal Year: 2004
    ..abstract_text> ..
  43. PERMEATION OF IRRITANT MIXTURES THRU PROTECTIVE MATERIAL
    SHANE QUE HEE; Fiscal Year: 2002
    ..The relationship of the fundamental independent variables to the kinetic parameters of permeation and to the Corrositex rating as the index of irritation will be determined and compared. ..
  44. A Unified Reporter Gene for Multi-Modality Imaging
    Jianghong Rao; Fiscal Year: 2005
    ..abstract_text> ..
  45. Inductively Coupled Plasma- Mass Spectrometer
    SHANE QUE HEE; Fiscal Year: 2003
    ..A team of researchers has been assembled whose research needs for elemental analyses are in the broad areas of environmental health, nutrition, biomedical and behavioral research. ..
  46. Near Infrared Diffused Light Imaging with Ultrasound
    Quing Zhu; Fiscal Year: 2002
    ..Completion of this research plan will serve to validate a novel method for detection and diagnosis of breast lesions, resulting in new opportunities for early detection and appropriate treatment of breast carcinoma. ..
  47. Single Shot OCT
    Daniel Hammer; Fiscal Year: 2006
    ..In addition, the developed instrument and the principles upon which it is based may be used to image other disease types throughout the human body. [unreadable] [unreadable] [unreadable]..
  48. In Vivo Measure of Platinum Containing Drugs by CT
    Jinming Gao; Fiscal Year: 2003
    ..This unique and capable feature of CT in non-invasive drug monitoring will potentially open new research opportunities for scientists or physicians in the fields of pharmacology, oncology and radiology. ..
  49. Becton Dickenson FACSAria Cell Sorter
    John Nolan; Fiscal Year: 2006
    ..The FACSAria plays a key role in the development of an advanced flow cytometry development and application capability at LJBI. [unreadable] [unreadable]..
  50. Fluorescence Sensor Probe for Transcutaneous Glucose Sensing
    Ralph Ballerstadt; Fiscal Year: 2008
    ..The overall result will be a healthier life for people with diabetes and lower medical costs for diabetes care for the society. [unreadable] [unreadable] [unreadable]..
  51. INTEGRATED PLATFORM FOR CHEMICAL ANALYSIS OF LIVE CELLS
    Michael Berns; Fiscal Year: 2001
    ..The achievement of the technological objectives interfaced into one platform will provide an enabling technology with a wide variety of applications in molecular medicine and biomedical research. ..
  52. MR imaging of myeloperoxidase activity
    Ralph Weissleder; Fiscal Year: 2007
    ..The ultimate goal of this research is to develop clinically useful imaging tools for the molecular assessment of atherosclerosis in vivo, which are currently limited. [unreadable] [unreadable] [unreadable]..
  53. Analysis of Phenolic Phytochemical by ESI-MS
    Jennifer Brodbelt; Fiscal Year: 2003
    ....
  54. Fast Optical Imager for tumor detection
    Xavier Intes; Fiscal Year: 2005
    ..abstract_text> ..
  55. Cognitive Orthosis with Interactive Task and Planning
    Edmund Lopresti; Fiscal Year: 2004
    ..e., astronauts). Evaluation of the Solo system will be conducted through focus groups and usability tests with clinicians, and clinical trials with individuals who have cognitive impairments. ..
  56. Adaptation to controlled vestibular stimulation
    DANIEL MERFELD; Fiscal Year: 2005
    ..All of these proposed specific aims will be investigated by measuring changes in the vestibulo-ocular responses induced by changes in chronic, patterned, electrical stimulation of the peripheral vestibular system. ..
  57. Diffuse optical tomography system for molecular imaging
    Ralph Weissleder; Fiscal Year: 2005
    ....
  58. Portable EEG Recorder for Household Surveys
    DANIEL HEDIN; Fiscal Year: 2007
    ..The proposed miniature portable EEG recorder with easily applied dry electrode technology can be applied in the home to collect data for longitudinal surveys of the elderly. [unreadable] [unreadable] [unreadable]..
  59. MR IMAGING OF GENE EXPRESSION
    Ralph Weissleder; Fiscal Year: 2004
    ..The long-term goal of this research is to extend the capabilities of MR and apply it to in vivo imaging of gene expression. ..
  60. Experimental Intracerebral Hemorrhage
    Justin Zivin; Fiscal Year: 2004
    ..These studies may provide insights about the causes of bleeding and neurological tissue damage that should be helpful in designing even more effective stroke therapies. ..
  61. Diffuse Light Imaging of Flow, Oxygen & Brain Metabolism
    Arjun Yodh; Fiscal Year: 2007
    ....
  62. FLOW IN THICK TISSUES PROBED BY DIFFUSING LIGHT
    Arjun Yodh; Fiscal Year: 2002
    ....
  63. Development of semicircular canal prostheses for studies of vestibular plasticity
    DANIEL MERFELD; Fiscal Year: 2009
    ..abstract_text> ..
  64. DET/COMPUTATION FOR DIFFUSE OPTICAL TOMOGRAPHY OF BREAST
    Arjun Yodh; Fiscal Year: 2002
    ..The third target of the program is clinical. They will perform pilot diffuse optical tomography on normal and high-risk patient populations with the assembled device and software. ..
  65. FLOW IN THICK TISSUES PROBED BY DIFFUSING LIGHT
    Arjun Yodh; Fiscal Year: 2001
    ....