ionizing radiation

Summary

Summary: Electromagnetic or corpuscular radiation capable of producing ions, directly or indirectly, in its passage through matter. The wavelengths are equal to or smaller than those of short (far) ultraviolet radiation and include gamma and X-rays and high-energy elementary particles.

Top Publications

  1. ncbi Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation
    Yingli Sun
    Department of Radiation Oncology, Division of Genomic Stability and DNA Repair, Harvard Medical School, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    FEBS Lett 580:4353-6. 2006
  2. ncbi Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways
    Chang Min Park
    Laboratory of Functional Genomics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    Cancer Res 66:8511-9. 2006
  3. ncbi Identification of ionizing radiation-responsive microRNAs in the IM9 human B lymphoblastic cell line
    Hwa Jun Cha
    Functional Genoproteome Research Centre, Konkuk University, Seoul 143 701, Korea
    Int J Oncol 34:1661-8. 2009
  4. ncbi Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity
    Kanaklata Roy
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Harvard Medical School, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Biochem Biophys Res Commun 344:821-6. 2006
  5. ncbi Computational approach for determining the spectrum of DNA damage induced by ionizing radiation
    H Nikjoo
    MRC Radiation and Genome Stability Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom
    Radiat Res 156:577-83. 2001
  6. pmc Significance analysis of microarrays applied to the ionizing radiation response
    V G Tusher
    Departments of Medicine and Biochemistry, Stanford University, 269 Campus Drive, Center for Clinical Sciences Research 1115, Stanford, CA 94305-5151, USA
    Proc Natl Acad Sci U S A 98:5116-21. 2001
  7. ncbi DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    Christopher J Bakkenist
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Nature 421:499-506. 2003
  8. pmc Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
    Brandi L Mahaney
    Department of Biochemistry and Molecular Biology and The Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Biochem J 417:639-50. 2009
  9. ncbi Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    C E Canman
    The Johns Hopkins School of Medicine, Oncology Center, Baltimore, MD 21205, USA
    Science 281:1677-9. 1998
  10. ncbi Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
    Claus Storgaard Sørensen
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    Cancer Cell 3:247-58. 2003

Detail Information

Publications350 found, 100 shown here

  1. ncbi Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation
    Yingli Sun
    Department of Radiation Oncology, Division of Genomic Stability and DNA Repair, Harvard Medical School, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    FEBS Lett 580:4353-6. 2006
    ..Further, anacardic acid sensitizes human tumor cells to the cytotoxic effects of ionizing radiation. These results demonstrate a central role for HATs such as Tip60 in regulating the DNA damage response...
  2. ncbi Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways
    Chang Min Park
    Laboratory of Functional Genomics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    Cancer Res 66:8511-9. 2006
    ..Several recent studies have reported that ionizing radiation (IR) enhances the invasion of tumor cells, but the mechanisms for this effect are not well understood...
  3. ncbi Identification of ionizing radiation-responsive microRNAs in the IM9 human B lymphoblastic cell line
    Hwa Jun Cha
    Functional Genoproteome Research Centre, Konkuk University, Seoul 143 701, Korea
    Int J Oncol 34:1661-8. 2009
    b>Ionizing radiation (IR) disrupts cellular homeostasis through multiple mechanisms including changes of the expression profile of genes...
  4. ncbi Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity
    Kanaklata Roy
    Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Harvard Medical School, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Biochem Biophys Res Commun 344:821-6. 2006
    ..In contrast, cells lacking the ATM protein are highly sensitive to ionizing radiation. The relationship between ATM protein expression and radiosensitivity in 3 glioma cell lines was examined...
  5. ncbi Computational approach for determining the spectrum of DNA damage induced by ionizing radiation
    H Nikjoo
    MRC Radiation and Genome Stability Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom
    Radiat Res 156:577-83. 2001
    To study the characteristics of molecular damage induced by ionizing radiation at the DNA level, Monte Carlo track simulation of energetic electrons and ions in liquid water, a canonical model of B-DNA, and a comprehensive classification ..
  6. pmc Significance analysis of microarrays applied to the ionizing radiation response
    V G Tusher
    Departments of Medicine and Biochemistry, Stanford University, 269 Campus Drive, Center for Clinical Sciences Research 1115, Stanford, CA 94305-5151, USA
    Proc Natl Acad Sci U S A 98:5116-21. 2001
    ..When the transcriptional response of human cells to ionizing radiation was measured by microarrays, SAM identified 34 genes that changed at least 1...
  7. ncbi DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    Christopher J Bakkenist
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Nature 421:499-506. 2003
    ..mutations of which are associated with the human disease ataxia-telangiectasia, mediates responses to ionizing radiation in mammalian cells...
  8. pmc Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
    Brandi L Mahaney
    Department of Biochemistry and Molecular Biology and The Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Biochem J 417:639-50. 2009
    ..They can be introduced by external sources such as IR (ionizing radiation), by chemotherapeutic drugs such as topoisomerase poisons and by normal biological processes such as V(D)J ..
  9. ncbi Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    C E Canman
    The Johns Hopkins School of Medicine, Oncology Center, Baltimore, MD 21205, USA
    Science 281:1677-9. 1998
    ..mutated in ataxia telangiectasia, ATM, acts upstream of p53 in a signal transduction pathway initiated by ionizing radiation. Immunoprecipitated ATM had intrinsic protein kinase activity and phosphorylated p53 on serine-15 in a ..
  10. ncbi Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
    Claus Storgaard Sørensen
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    Cancer Cell 3:247-58. 2003
    ..human Chk1 triggered supraphysiological accumulation of the S phase-promoting Cdc25A phosphatase, prevented ionizing radiation (IR)-induced degradation of Cdc25A, and caused radioresistant DNA synthesis (RDS)...
  11. pmc Exposure to low-dose ionizing radiation from medical imaging procedures
    Reza Fazel
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30306, USA
    N Engl J Med 361:849-57. 2009
    The growing use of imaging procedures in the United States has raised concerns about exposure to low-dose ionizing radiation in the general population.
  12. ncbi A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
    Y Gao
    Howard Hughes Medical Institute, The Children s Hospital, Department of Genetics, Harvard University Medical School, Boston, Massachusetts 02115, USA
    Cell 95:891-902. 1998
    XRCC4 was identified via a complementation cloning method that employed an ionizing radiation (IR)-sensitive hamster cell line...
  13. pmc Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
    M Fiscella
    Advanced BioScience Laboratories Basic Research Program, Molecular Oncology Section, Molecular Virology and Carcinogenesis Laboratory, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 94:6048-53. 1997
    Exposure of mammalian cells to ionizing radiation (IR) induces a complex array of cellular responses including cell cycle arrest and/or apoptosis...
  14. ncbi Gene expression changes in mouse brain after exposure to low-dose ionizing radiation
    E Yin
    Biology and Biotechnology Research Program Lawrence Livermore National Laboratory Livermore CA 94 550 USA
    Int J Radiat Biol 79:759-75. 2003
    ..To characterize the cellular functions associated with the altered transcript profiles of mouse brain exposed to low-dose in vivo gamma-irradiation...
  15. pmc Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints
    Hui Zhao
    Department of Cell Biology and Physiology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Proc Natl Acad Sci U S A 99:14795-800. 2002
    ..Here we show that human cells lacking Chk1 exhibit defects in both the ionizing radiation (IR)-induced S and G(2) checkpoints...
  16. ncbi Protection against ionizing radiation by antioxidant nutrients and phytochemicals
    Joseph F Weiss
    Office of Health Studies, US Department of Energy, EH 6 270 Corporate Square, 1000 Independence Avenue, SW, Washington, DC 20585 0270, USA
    Toxicology 189:1-20. 2003
    The potential of antioxidants to reduce the cellular damage induced by ionizing radiation has been studied in animal models for more than 50 years...
  17. pmc Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells
    Olga Momcilovic
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Stem Cells 27:1822-35. 2009
    ..In summary, these results indicate that human ES cells activate the DNA damage checkpoint, resulting in an ATM-dependent G(2) arrest. However, these cells re-enter the cell cycle with prominent mitotic spindle defects...
  18. pmc Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans
    Tatiana Garcia-Muse
    DNA Damage Response Laboratory, Cancer Research UK, The London Research Institute, Clare Hall Laboratories, South Mimms, UK
    EMBO J 24:4345-55. 2005
    ..function in the S-phase checkpoint and also cooperate with atm-1 in the checkpoint response to DSBs after ionizing radiation (IR) to induce cell cycle arrest or apoptosis via the cep-1(p53)/egl-1 pathway...
  19. ncbi Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
    Juan Guinea Viniegra
    CRIB Facultad de Medicina, Universidad de Castilla La Mancha, 02071 Albacete, Spain
    J Biol Chem 280:4029-36. 2005
    ..This study proposes new clues in the search of the unknown PDK2 and new explanations for the radiosensitivity or insulin intolerance described more than 30 years ago in AT patients...
  20. ncbi Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
    K H Herzog
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38101, USA
    Science 280:1089-91. 1998
    ..Resistance to apoptosis in the developing central nervous system (CNS) of Atm-/- mice was observed after ionizing radiation. This lack of death occurred in diverse regions of the CNS, including the cerebellum, which is markedly ..
  21. pmc Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiation
    Yongqing Liu
    Environmental Sciences and Life Sciences Divisions, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    Proc Natl Acad Sci U S A 100:4191-6. 2003
    ..radiodurans R1 (DEIRA) is a bacterium best known for its extreme resistance to the lethal effects of ionizing radiation, but the molecular mechanisms underlying this phenotype remain poorly understood...
  22. ncbi Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology
    Douglas R Spitz
    B180 Medical Laboratories, Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Metastasis Rev 23:311-22. 2004
    Exposure of eukaryotic cells to ionizing radiation (IR) results in the immediate formation of free radicals that last a matter of milliseconds...
  23. ncbi Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro
    William F Morgan
    Radiation Oncology Research Laboratory and Greenebaum Cancer Center, Department of Radiation Oncology, University of Maryland, Baltimore, Maryland 21201 5525, USA
    Radiat Res 159:567-80. 2003
    ..A number of non-targeted, delayed effects of ionizing radiation have been described that challenge this dogma and pose new challenges to evaluating potential hazards ..
  24. pmc DdrB protein, an alternative Deinococcus radiodurans SSB induced by ionizing radiation
    Cédric A Norais
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 284:21402-11. 2009
    Deinococcus radiodurans exhibits an extraordinary resistance to the effects of exposure to ionizing radiation (IR)...
  25. ncbi Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient
    E Riballo
    MRC Cell Mutation Unit, University of Sussex, Brighton, BN1 9RR, UK
    Curr Biol 9:699-702. 1999
    ..The defect, however, may confer a predisposition to leukaemia...
  26. pmc Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists
    Parveen Bhatti
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Radiat Res 173:214-24. 2010
    ..One approach is to evaluate variation in risk by genotype based on known breast carcinogens, such as ionizing radiation. Given the public health concerns associated with recent increases in medical radiation exposure, this ..
  27. ncbi Radiation carcinogenesis
    J B Little
    Department of Cancer Cell Biology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 21:397-404. 2000
    ..review several of these areas of research, as they may relate specifically to the induction of cancer by ionizing radiation. Knowledge of the critical DNA damage of biologic importance, and how this damage is repaired, will be ..
  28. ncbi Non-targeted bystander effects induced by ionizing radiation
    William F Morgan
    Radiation Oncology Research Laboratory, and Marlene and Stewart Greenebaum Cancer Center, BRB 7 011, University of Maryland, Baltimore, MD 21201 1509, USA
    Mutat Res 616:159-64. 2007
    ..refer to those responses occurring in cells that were not subject to energy deposition events following ionizing radiation. These bystander cells may have been neighbors of irradiated cells, or physically separated but subject to ..
  29. ncbi NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors
    Xingzhi Xu
    Department of Pathology, School of Medicine, Yale University, 310 Cedar St, BML342, New Haven, Connecticut 06510, USA
    FASEB J 17:1842-8. 2003
    ..We have previously shown that NFBD1 is an early participant in DNA damage signaling pathways and that ionizing radiation-induced nuclear foci (IRIF) of NFBD1 colocalize with several DNA checkpoint signaling and repair factors...
  30. ncbi Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects
    William F Morgan
    Radiation Oncology Research Laboratory and Greenebaum Cancer Center, Department of Radiation Oncology, University of Maryland, Baltimore, Maryland 21201 5525, USA
    Radiat Res 159:581-96. 2003
    The goal of this review is to summarize the evidence for non-targeted and delayed effects of exposure to ionizing radiation in vivo...
  31. pmc Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status
    Oanh N L Le
    Centre de recherche CHU Ste Justine, Montreal, QC, Canada
    Aging Cell 9:398-409. 2010
    ..Together, our results provide compelling evidence that exposure to IR induces long-term expression of senescence markers in vivo, an effect that may contribute to the reduced tissue functionality observed in cancer survivors...
  32. ncbi Plasma membrane signaling induced by ionizing radiation
    Isabelle Corre
    Inserm UMR U892, Centre de Recherche en Cancérologie Nantes Angers, Institut de Recherche Therapeutique, 8 quai Moncousu, F 44007 Nantes cedex 1, France
    Mutat Res 704:61-7. 2010
    For decades, DNA has been considered as the main cellular target of deleterious effects of ionizing radiation (IR)...
  33. pmc MicroRNA expression after ionizing radiation in human endothelial cells
    Mechthild Wagner-Ecker
    Department of Radiation Oncology, German Cancer Research Center and University of Heidelberg Medical Center, Heidelberg, Germany
    Radiat Oncol 5:25. 2010
    ..MicroRNAs have emerged as master switchers of the cellular transcriptome. Here, we seek to investigate the role of miRNAs in primary human dermal microvascular endothelial cells (HDMEC) after ionizing radiation.
  34. ncbi Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation
    N Takao
    Department of Molecular Pathology, Faculty of Medicine, Kanazawa University, Ishikawa, Japan
    Oncogene 18:7002-9. 1999
    ..Furthermore, ATM-/- DT40 cells were sensitive to ionizing radiation and showed highly elevated frequencies of both spontaneous and radiation-induced chromosomal aberrations...
  35. ncbi ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation
    Shin ichi Saito
    Biology Department, Brookhaven National Laboratory, 50 Bell Avenue, Upton, New York 11973, USA
    J Biol Chem 277:12491-4. 2002
    ..In response to ionizing radiation (IR), ATM, the gene product mutated in ataxia telangiectasia, stabilizes and activates p53 through ..
  36. ncbi Real-time PCR analysis of micro-RNA expression in ionizing radiation-treated cells
    M Ahmad Chaudhry
    Department of Medical Laboratory and Radiation Sciences, University of Vermont, Burlington, VT 05405, USA
    Cancer Biother Radiopharm 24:49-56. 2009
    The cellular response to ionizing radiation exposure is very complex and involves many pathways...
  37. pmc Ionizing radiation-induced oxidative stress alters miRNA expression
    Nicole L Simone
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    PLoS ONE 4:e6377. 2009
    ..Alterations in miRNA expression may occur following exposure to several stress-inducing anticancer agents including ionizing radiation, etoposide, and hydrogen peroxide (H(2)O(2)).
  38. pmc Megabase chromatin domains involved in DNA double-strand breaks in vivo
    E P Rogakou
    Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 146:905-16. 1999
    The loss of chromosomal integrity from DNA double-strand breaks introduced into mammalian cells by ionizing radiation results in the specific phosphorylation of histone H2AX on serine residue 139, yielding a specific modified form named ..
  39. ncbi Responses of normal cells to ionizing radiation
    H Peter Rodemann
    Department of Radiation Oncology, Division of Radiobiology and Molecular Environmental Research, Eberhard Karls University, Tubingen, Germany
    Semin Radiat Oncol 17:81-8. 2007
    ..Some of the underlying molecular and cellular response pathways leading to radiation-induced tissue remodeling will be discussed, with special emphasis on vascular and parenchymal tissues...
  40. pmc DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
    Tsuyoshi Ikura
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Seiryoumachi 2 1, Aobaku Sendai 980 8575, Japan
    Mol Cell Biol 27:7028-40. 2007
    ..We conclude that the sequential acetylation and ubiquitination of H2AX by TIP60-UBC13 promote enhanced histone dynamics, which in turn stimulate a DNA damage response...
  41. ncbi Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1
    Darren R Krause
    Signal Transduction Lab, Cancer and Cell Biology Division, Queensland Institute of Medical Research, 300 Herston Rd, QLD 4029, Australia
    Oncogene 22:5927-37. 2003
    ..Overall, we propose that ATM activation is not linked solely to DSBs and that ATM participates in initiating signaling pathways in response to replication block and UV-induced DNA damage...
  42. ncbi Biomarkers for human radiation exposure
    M Ahmad Chaudhry
    Department of Medical Laboratory and Radiation Sciences, College of Nursing and Health Sciences, University of Vermont, 302 Rowell Building, Burlington, VT 05405, USA
    J Biomed Sci 15:557-63. 2008
    ..The examination of gene expression after ionizing radiation exposure could serve as a potential molecular marker for biodosimetry...
  43. ncbi Hematologic consequences of exposure to ionizing radiation
    Nicholas Dainiak
    Department of Medicine, Bridgeport Hospital, Yale University School of Medicine, Bridgeport, Conn 06610, USA
    Exp Hematol 30:513-28. 2002
    From the early 1900s, it has been known that ionizing radiation (IR) impairs hematopoiesis through a variety of mechanisms...
  44. ncbi A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells
    A M Martelli
    Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell Apparato Locomotore, Sezione di Anatomia, Cell Signalling Laboratory, Universita di Bologna, Bologna, Italy
    Leukemia 17:1794-805. 2003
    ..as Ly294002 in lowering the sensitivity threshold of HL60 cells to chemotherapeutic drugs, TRAIL, ATRA, and ionizing radiation. Our findings demonstrate that, at a concentration which does not affect PI3K activity, the Akt inhibitor ..
  45. ncbi Identification of mammalian proteins cross-linked to DNA by ionizing radiation
    Sharon Barker
    Department of Oncology, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2
    J Biol Chem 280:33826-38. 2005
    b>Ionizing radiation (IR) is an important environmental risk factor for various cancers and also a major therapeutic agent for cancer treatment...
  46. ncbi Risks associated with ionizing radiation
    M P Little
    Department of Epidemiology and Public Health, Imperial College Faculty of Medicine, St Mary s Campus, London, UK
    Br Med Bull 68:259-75. 2003
    ..risks (the latter including the risk of cancer and of hereditary disease) associated with exposure to ionizing radiation. Particular attention is paid to cancer risks following exposure to man-made low linear energy transfer ..
  47. ncbi Static magnetic fields aggravate the effects of ionizing radiation on cell cycle progression in bone marrow stem cells
    Amir Sabet Sarvestani
    Department of Biophysics, Faculty of Bioscience, Tarbiat Modares University, Tehran, Iran
    Micron 41:101-4. 2010
    ....
  48. ncbi Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation
    Zuzana Horejsi
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, Copenhagen DK 2100 Denmark
    Oncogene 23:3122-7. 2004
    ..is a tumour suppressor and a key activator of genome integrity checkpoints in mammalian cells exposed to ionizing radiation (IR) and other insults that elicit DNA double-strand breaks (DSBs)...
  49. ncbi Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect
    Edouard I Azzam
    Department of Radiology, UMDNJ, New Jersey Medical School, Newark, NJ 07103
    Oncogene 22:7050-7. 2003
    Evidence accumulated over the past two decades has indicated that exposure of cell populations to ionizing radiation results in significant biological effects occurring in both the irradiated and nonirradiated cells in the population...
  50. ncbi Involvement of the hepatocyte growth factor/scatter factor receptor c-met and of Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation
    D M Aebersold
    Department of Radiation Oncology, Inselspital, University of Bern, Bern, Switzerland
    Int J Cancer 96:41-54. 2001
    ..factor (HGF/SF) and its receptor c-met, exerts an inhibitory influence on apoptosis induced by ionizing radiation in vitro...
  51. ncbi Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
    K K Wong
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Genet 26:85-8. 2000
    ..Terc), to assess the role of telomerase and telomere function on the cellular and organismal response to ionizing radiation. Although the loss of telomerase activity per se had no discernable impact on the response to ionizing ..
  52. ncbi Analyzing cell cycle checkpoints after ionizing radiation
    Bo Xu
    Department of Genetics and Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, USA
    Methods Mol Biol 281:283-92. 2004
    Several methods to measure cell cycle perturbation after exposure to ionizing radiation are presented in this chapter...
  53. ncbi The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation
    Naoya Shikazono
    Japan Atomic Energy Agency, Advanced Research Science Center, 2 4 Shirakata Shirane, Tokai mura, Ibaraki 319 1195, Japan
    J Radiat Res 50:27-36. 2009
    After living cells are exposed to ionizing radiation, a variety of chemical modifications of DNA are induced either directly by ionization of DNA or indirectly through interactions with water-derived radicals...
  54. ncbi Comprehensive analysis of time- and dose-dependent patterns of gene expression in a human mesenchymal stem cell line exposed to low-dose ionizing radiation
    Young Woo Jin
    Division of Radiation Effect Research, Radiation Health Research Institute of KHNP, Seoul 132 703, Korea
    Oncol Rep 19:135-44. 2008
    We focused on the transcriptional responses induced by low and very low doses of ionizing radiation with time effect. Regardless of their importance only a few limited studies have been done...
  55. ncbi Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation
    Ilja Demuth
    Molecular Genetics Program, Benaroya Research Institute, Seattle, WA 98101 2795, USA
    Oncogene 23:8611-8. 2004
    ..In addition, siRNA knockdown of hSNM1B rendered cells sensitive to ionizing radiation, suggesting the possibility of hSNM1B involvement in homologous recombination repair of double-strand breaks ..
  56. ncbi Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts
    Mykyta V Sokolov
    Department of Nuclear Medicine, Clinical Center, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Oncogene 24:7257-65. 2005
    ..These studies show that H2AX phosphorylation is an early step in the bystander effect and that the DNA DSBs underlying gamma-H2AX focus formation may be responsible for its downstream manifestations...
  57. pmc SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation
    Yong Xu
    Department of Radiation Medicine, University of Kentucky, College of Medicine, Lexington, KY 40536, USA
    Mol Cancer Ther 7:2367-76. 2008
    ..Here, we show that ionizing radiation (IR) enhances nuclear import of RelB, leading to up-regulation of its target gene, manganese superoxide ..
  58. ncbi Medical radiation exposure in the U.S. in 2006: preliminary results
    Fred A Mettler
    Radiology and Nuclear Medicine Service, New Mexico VA Health Care System, Albuquerque, NM 87108, USA
    Health Phys 95:502-7. 2008
    ..Nuclear medicine accounted for about 4% of all procedures but 26% of the total collective dose. Medical radiation exposure is now approximately equal to natural background radiation...
  59. pmc Role of DNA repair by nonhomologous-end joining in Bacillus subtilis spore resistance to extreme dryness, mono- and polychromatic UV, and ionizing radiation
    Ralf Moeller
    Space Life Sciences Laboratory, Building M6 1025 SLSL, Kennedy Space Center, FL 32953, USA
    J Bacteriol 189:3306-11. 2007
    The role of DNA repair by nonhomologous-end joining (NHEJ) in spore resistance to UV, ionizing radiation, and ultrahigh vacuum was studied in wild-type and DNA repair mutants (recA, splB, ykoU, ykoV, and ykoU ykoV mutants) of Bacillus ..
  60. pmc Bevacizumab-induced tumor vessel remodeling in rhabdomyosarcoma xenografts increases the effectiveness of adjuvant ionizing radiation
    Adrianne L Myers
    Department of Surgery, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Pediatr Surg 45:1080-5. 2010
    ..This may improve the efficacy of adjuvant ionizing radiation (IR)...
  61. ncbi Differential recovery of neural stem cells in the subventricular zone and dentate gyrus after ionizing radiation
    Nina A K Hellström
    Center for Brain Repair and Rehabilitation, Institute for Neuroscience and Physiology, University of Gothenburg, Sweden
    Stem Cells 27:634-41. 2009
    ..However, the long-term effects on stem cells and neurogenesis in these two areas differ significantly: the dentate gyrus is severely affected long-term, whereas the SVZ appears to recover with time...
  62. pmc A model of cardiovascular disease giving a plausible mechanism for the effect of fractionated low-dose ionizing radiation exposure
    Mark P Little
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom
    PLoS Comput Biol 5:e1000539. 2009
    ..The analysis of the present paper suggests that linear extrapolation would be appropriate for this endpoint...
  63. pmc Regulation of protein synthesis by ionizing radiation
    Steve Braunstein
    Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Cell Biol 29:5645-56. 2009
    b>Ionizing radiation (IR) is a physiologically important stress to which cells respond by the activation of multiple signaling pathways...
  64. ncbi Immune modulation by ionizing radiation and its implications for cancer immunotherapy
    Eric J Friedman
    Radiation Oncology Branch Radiation Oncology Sciences Program NCI NIH, Building 10, Rm B3B69, NIH NCI, Bethesda, MD 20892, USA
    Curr Pharm Des 8:1765-80. 2002
    b>Ionizing radiation exhibits immunomodulatory properties, which could portend a future collaboration of cancer immunotherapy with radiation therapy...
  65. ncbi Effects of ionizing radiation on the mechanical properties of human bone
    J D Currey
    Department of Biology, University of York, England, U K
    J Orthop Res 15:111-7. 1997
    Allogeneic bone grafts are frequently sterilized by means of ionizing radiation. We investigated the effects of ionizing radiation on both quasistatic and impact mechanical properties of human bone...
  66. pmc Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability
    Jennifer M Leonard
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    J Cell Biol 183:385-91. 2008
    ..dysregulates the Shh pathway and increases genomic instability and the development of spontaneous and ionizing radiation (IR)-induced tumors by an unknown mechanism...
  67. ncbi TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks
    Sherif F El-Khamisy
    Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton, UK
    DNA Repair (Amst) 6:1485-95. 2007
    ..Here we demonstrate that TDP1 is also required for the repair of SSBs induced by ionizing radiation (IR), though not measurably for IR-induced DNA double-strand breaks (DSBs)...
  68. pmc Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells
    Daojing Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 69:8200-7. 2009
    ..We showed that ionizing radiation induced cellular senescence of hMSC over a period of 10 days, showing a critical transition between days 3 ..
  69. pmc Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection
    Ekaterina Dadachova
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 100:10942-7. 2003
    ..b>Ionizing radiation can kill microorganisms quickly and efficiently, but this modality has not been exploited as a therapeutic ..
  70. ncbi Ringlike structure of the Deinococcus radiodurans genome: a key to radioresistance?
    Smadar Levin-Zaidman
    Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    Science 299:254-6. 2003
    ....
  71. ncbi Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses
    Liang Hao Ding
    Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, California, 94720, USA
    Radiat Res 164:17-26. 2005
    Several types of cellular responses to ionizing radiation, such as the adaptive response or the bystander effect, suggest that low-dose radiation may possess characteristics that distinguish it from its high-dose counterpart...
  72. pmc Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis
    Holger Stephan
    Cell Cycle Control Laboratory, School of Natural Sciences, National University of Ireland, Galway, Galway, Ireland
    Nucleic Acids Res 37:6028-41. 2009
    ..In mitotic cells treated with ionizing radiation (IR), we observed a rapid hyperphosphorylation of RPA2 in addition to its mitotic phosphorylation at S23 and ..
  73. ncbi The Ku-dependent non-homologous end-joining but not other repair pathway is inhibited by high linear energy transfer ionizing radiation
    Hongyan Wang
    Department of Radiation Oncology and Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    DNA Repair (Amst) 7:725-33. 2008
    b>Ionizing radiation (IR) induced DNA double strand breaks (DSBs) are repaired by both non-homologous end-joining (NHEJ) and homologous recombination repair (HRR) in mammalian cells...
  74. ncbi Regulation of ATM in DNA double strand break repair accounts for the radiosensitivity in human cells exposed to high linear energy transfer ionizing radiation
    Lian Xue
    School of Radiation Medicine and Public Health, Medical College of Soochow University, Suzhou, China
    Mutat Res 670:15-23. 2009
    ..b>Ionizing radiation (IR) induced DNA DSBs are repaired by both non-homologous end-joining (NHEJ) and homologous recombination ..
  75. pmc Ionizing radiation activates the Nrf2 antioxidant response
    J Tyson McDonald
    Division of Molecular and Cellular Oncology, Department of Radiation Oncology, and Pasarow Mass Spectrometry Laboratory, David Geffen School of Medicine at University of California, Los Angeles, California 90095 1714, USA
    Cancer Res 70:8886-95. 2010
    ..In this study, we report that single doses of ionizing radiation from 2 to 8 Gy activate ARE-dependent transcription in breast cancer cells in a dose-dependent manner, but ..
  76. pmc Radiation and mortality of workers at Oak Ridge National Laboratory: positive associations for doses received at older ages
    D B Richardson
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 8050, USA
    Environ Health Perspect 107:649-56. 1999
    We examined associations between low-level exposure to ionizing radiation and mortality among 14,095 workers hired at the Oak Ridge National Laboratory between 1943 and 1972...
  77. ncbi The pathology of ionizing radiation as defined by morphologic patterns
    Luis Felipe Fajardo
    Stanford University School of Medicine and Veterans Affairs Health Care System, Palo Alto, California 94304 1290, USA
    Acta Oncol 44:13-22. 2005
    This article presents a brief description of the effects of ionizing radiation in human tissues, as seen by the Pathologist...
  78. ncbi Biological indicators for the identification of ionizing radiation exposure in humans
    S A Amundson
    NIH, National Cancer Institute, 37 Convent Dr, Bldg 37, Bethesda, MD 20892, USA
    Expert Rev Mol Diagn 1:211-9. 2001
    ..Developments in high-throughput gene expression profiling may enable future development of a rapid and noninvasive testing method for application to potentially exposed populations...
  79. ncbi Fractionated ionizing radiation exposure induces apoptosis through caspase-3 activation and reactive oxygen species generation
    Barbara Bucci
    AFAR Centro Ricerca S Pietro, Fatebenefratelli Hospital, Via Cassia 600, 00189 Rome, Italy
    Anticancer Res 26:4549-57. 2006
    ..treatment adjuvant to surgery since its ability to prolong median survival of patients with malignant astrocytoma has been shown; nevertheless the ionizing radiation (IR) treatment fails in a considerable number of astrocytoma patients.
  80. ncbi Ionizing radiation impairs the formation of trace fear memories and reduces hippocampal neurogenesis
    Pragathi Achanta
    Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Behav Neurosci 123:1036-45. 2009
    ....
  81. pmc Cisplatin sensitizes cancer cells to ionizing radiation via inhibition of nonhomologous end joining
    Heather J Boeckman
    Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    Mol Cancer Res 3:277-85. 2005
    The combination of cisplatin and ionizing radiation (IR) treatment represents a common modality for treating a variety of cancers...
  82. ncbi Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation
    Simon N Powell
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Oncogene 22:5784-91. 2003
    ..defect in homologous recombination, tumors that arise in BRCA carriers are likely to be more sensitive to ionizing radiation. This review summarizes recent investigations about the nature of the defect in DNA repair, and highlights ..
  83. ncbi Health risks of low dose ionizing radiation in humans: a review
    Kedar N Prasad
    Center for Vitamins and Cancer Research, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Exp Biol Med (Maywood) 229:378-82. 2004
    ..Low doses of ionizing radiation should not be considered insignificant for risks of somatic and heritable mutations and neoplastic and ..
  84. ncbi Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation
    Sonya Wieler
    Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 278:18914-21. 2003
    ..To investigate the role of PARP-1 in the p53 response to ionizing radiation in human cells, PARP-1 function was disrupted in wild-type p53 expressing MCF-7 and BJ/TERT cells using two ..
  85. ncbi Manifestations and mechanisms of non-targeted effects of ionizing radiation
    Eric G Wright
    University of Dundee, Centre for Oncology and Molecular Medicine, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Mutat Res 687:28-33. 2010
    A well-established radiobiological paradigm is that the biological effects of ionizing radiation occur in irradiated cells as a consequence of the DNA damage they incur...
  86. ncbi Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms
    Aimin Meng
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, Charleston, SC 29425, USA
    Exp Hematol 31:1348-56. 2003
    b>Ionizing radiation (IR) and busulfan (BU) are commonly used as preconditioning regimens for bone marrow transplantation (BMT)...
  87. ncbi Ionizing radiation exposure and cancer risk among Norwegian nurses
    Jenny Anne S Lie
    Cancer Registry of Norway, Oslo, Norway
    Eur J Cancer Prev 17:369-75. 2008
    The influence of occupational exposure to ionizing radiation on risk of radiation-related cancers was studied among Norwegian nurses...
  88. ncbi IgH class switching and translocations use a robust non-classical end-joining pathway
    Catherine T Yan
    Howard Hughes Medical Institute, of Genetics, Boston, Massachusetts 02115, USA
    Nature 449:478-82. 2007
    ..In the absence of C-NHEJ, this alternative end-joining pathway also frequently joins Igh locus breaks to other chromosomes to generate translocations...
  89. pmc Expression of the Ku70 subunit (XRCC6) and protection from low dose ionizing radiation during zebrafish embryogenesis
    Catherine L Bladen
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Neurosci Lett 422:97-102. 2007
    ..However, exposure of Ku70 morpholino-injected embryos to low doses of ionizing radiation leads to marked cell death throughout the developing brain, spinal cord, and tail...
  90. ncbi Modulation of apoptosis of eckol against ionizing radiation in mice
    Eunjin Park
    College of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju 690 756, South Korea
    Biochem Biophys Res Commun 372:792-7. 2008
    ..Thus, eckol that can protect cells and tissues against ionizing radiation may have considerable potential as adjuncts to successful radiotherapy.
  91. ncbi Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells
    Joseph N Contessa
    The Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA
    Oncogene 21:4032-41. 2002
    In this study we have investigated the effects of low dose ionizing radiation (2 Gy) on p70 S6 kinase and Akt signaling with respect to Erb-B receptors in both the A431 squamous and the MDA-MB-231 mammary carcinoma cell lines...
  92. ncbi Adenovirus-mediated expression of Tob1 sensitizes breast cancer cells to ionizing radiation
    Yang Jiao
    School of Radiology and Public Health, Soochow University, Suzhou 215123, China
    Acta Pharmacol Sin 28:1628-36. 2007
    ....
  93. ncbi Ionizing radiation as a response-enhancing agent for CD95-mediated apoptosis
    M A Sheard
    Department of Cellular and Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Int J Cancer 96:213-20. 2001
    CD95 (Fas/APO-1) is a death receptor on the surface of a wide variety of cell types. In most cells examined, ionizing radiation acts as a response-enhancing agent for CD95-mediated cell death...
  94. ncbi Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line
    Kristina Viktorsson
    Cancer Center Karolinska, Department of Oncology Pathology, Karolinska Institute, S 171 76 Stockholm, Sweden
    Exp Cell Res 289:256-64. 2003
    We have here examined ionizing radiation (IR)-induced apoptotic signaling in one IR-sensitive small cell lung carcinoma (SCLC) and one resistant non-small cell lung carcinoma (NSCLC) cell line, both harboring mutant p53...
  95. ncbi Analysis of ionizing radiation-induced foci of DNA damage repair proteins
    Lieneke R van Veelen
    Department of Cell Biology and Genetics, Erasmus MC, University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mutat Res 574:22-33. 2005
    ..b>Ionizing radiation-induced foci can be visualized by immuno-staining...
  96. ncbi Salt shield: intracellular salts provide cellular protection against ionizing radiation in the halophilic archaeon, Halobacterium salinarum NRC-1
    A Kish
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Environ Microbiol 11:1066-78. 2009
    ..NRC-1 was used as a model system to investigate cellular damage induced by exposure to high doses of ionizing radiation (IR)...
  97. ncbi hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage
    Abdeladim Moumen
    The Wellcome Trust and Cancer Research UK Gurdon Institute and Department of Zoology, Cambridge University, Tennis Court Road, Cambridge CB2 1QN, United Kingdom
    Cell 123:1065-78. 2005
    ..These findings establish hnRNP K as a new HDM2 target and show that, by serving as a cofactor for p53, hnRNP K plays key roles in coordinating transcriptional responses to DNA damage...
  98. ncbi ATM activation by ionizing radiation requires BRCA1-associated BAAT1
    Jason A Aglipay
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA
    J Biol Chem 281:9710-8. 2006
    ATM (ataxia telangiectasia mutated) is required for the early response to DNA-damaging agents such as ionizing radiation (IR) that induce DNA double-strand breaks. Cells deficient in ATM are extremely sensitive to IR...
  99. ncbi A fast Monte Carlo algorithm to simulate the spectrum of DNA damages formed by ionizing radiation
    V A Semenenko
    Purdue University, School of Health Sciences, West Lafayette, Indiana 47907 2051, USA
    Radiat Res 161:451-7. 2004
    b>Ionizing radiation produces both singly and multiply damaged DNA sites. Multiply damaged sites (MDS) have been implicated in radiation-induced cell killing and mutagenesis...
  100. ncbi Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks
    Benjamin P C Chen
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9187, USA
    J Biol Chem 280:14709-15. 2005
    ..Here we report the ionizing radiation (IR)-induced autophosphorylation of DNA-PKcs at a novel site, serine 2056, the phosphorylation of which is ..
  101. ncbi Molecular mechanisms of ionizing radiation-induced apoptosis
    D Watters
    Cancer Research Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Immunol Cell Biol 77:263-71. 1999
    b>Ionizing radiation activates not only signalling pathways in the nucleus as a result of DNA damage, but also signalling pathways initiated at the level of the plasma membrane...

Research Grants76

  1. X-RAYS INDUCE EXOCYTOSIS OF ENDOTHELIAL P-SELECTIN
    Dennis Hallahan; Fiscal Year: 2002
    ..WPB components and observed that several of these proteins translocate to the vascular lumen in response to ionizing radiation. These proteins included CD62P (P-selectin), CD63, Interleukin-8, and von Willebrand factor (vWF)...
  2. Optimization of DNA Repair by Abh8
    Lauren Endres; Fiscal Year: 2013
    ..p53 are known to cause a predisposition to cancer development as well as hypersensitivity to ultraviolet and ionizing radiation [1-3]...
  3. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..role of TxRd1 as a critical mediator of the antitumorigeniceffects of curcumin alone and in combination with ionizing radiation in oraopharyngeal cancer cell lines, in vitro and in vivo. ...
  4. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The toxicity of ionizing radiation (IR) in mammals is largely due to damage to the most radiosensitive tissues, the gastrointestinal (GI) tract and the hematopoietic (HP) system...
  5. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    ..Moreover, the genetic instability of the somatic cells in the FA patient means that exposure to ionizing radiation, environmental carcinogens and chemotherapeutic agents pose unique risks to the patient...
  6. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    THOMAS EDWARD WILSON; Fiscal Year: 2010
    ..and folate stress, which inhibit replication through different mechanisms than aphidicolin, and on ionizing radiation and bleomycin, which lead directly to DNA DSBs...
  7. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
    ..In our preclinical models, ionizing radiation rapidly activated osteoclastic bone resorption and caused a decline in trabecular-bone volume fraction of 20-..
  8. DNA Damage Checkpoint and Cancer
    Toru Ouchi; Fiscal Year: 2012
    ..to explore the signal transduction mechanisms involved in BAAT1/ATM activation after DNA damage induced by ionizing radiation (IR) and chemicals, and examine how BAAT1/ATM pathway functions together with other checkpoint proteins such ..
  9. Role of beta-endorphin in cancer therapy induced fatigue
    David E Fisher; Fiscal Year: 2013
    ..this pathway is exerted by p53 (DNA damage sensor), we tested whether non-UV DNA damage triggers, especially ionizing radiation or certain chemotherapeutics, may also trigger 2-endorphin synthesis and found that they do...
  10. Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrial
    Lynn Harrison; Fiscal Year: 2013
    ..that the cKumyc when targeted to the mitochondria in HNSCC cells will bind to DSBs following treatment with ionizing radiation or cisplatin, disrupting repair, causing mitochondrial genome fragmentation, reactive oxygen species (ROS) ..
  11. 14th International Workshop on Ataxia-Telangiectasia and ATM
    Richard A Gatti; Fiscal Year: 2010
    ..Cells that lack ATM are highly sensitive to ionizing radiation (IR) and other DNA damaging agents...
  12. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2011
    ..near Chernobyl had risen by 2 orders of magnitude, most likely as a consequence of increased exposure to ionizing radiation. The routes and mechanisms by which radiation generated these additional thyroid cancers remain mysterious...
  13. Beta 2-Microglobulin signaling and targeting in bone metastasis
    Leland W K Chung; Fiscal Year: 2013
    ..evaluate antibody toxicity in mice, and determine the synergistic interaction between anti-b2-M mAb plus ionizing radiation on the growth of prostate cancer cells and tumors...
  14. The role of LKB1 in the maintenance of genomic stability.
    Zhi Xiang Xu; Fiscal Year: 2013
    ..LKB1-deficient cells exhibit a delayed DDR and reduced DNA repair after exposure to ionizing radiation (IR)...
  15. Imaging of Aortic Atherosclerosis and Inflammation in the Metabolic Syndrome
    Warren J Manning; Fiscal Year: 2012
    ..sensitivity of CMR for providing information regarding plaque components, including inflammation in a non-ionizing radiation environment and in the absence of iodinated contrast...
  16. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2011
    ..provided by applicant): Free radicals play a major role in human diseases such as iron sulfate poisoning, ionizing radiation, oxygen toxicity in premature infants treated with hyperbaric oxygen, ultraviolet radiation-induced cancer ..
  17. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2012
    ..provided by applicant): Free radicals play a major role in human diseases such as iron sulfate poisoning, ionizing radiation, oxygen toxicity in premature infants treated with hyperbaric oxygen, ultraviolet radiation-induced cancer ..
  18. Development of a Porcine Model of Ataxia-Telangiectasia
    Christopher Rogers; Fiscal Year: 2011
    ..brain tumors), immunodeficiency, insulin-resistant diabetes, chromosomal instability, sensitivity to ionizing radiation, susceptibility to bronchopulmonary disease, and the nearly complete absence of a thymus...
  19. Stem Cell Based Therapy For Radiation Induced Gastrointestinal Syndrome
    Chandan Guha; Fiscal Year: 2010
    ..also a model for an "early responding" tissue that is frequently targeted by DNA damaging agents, such as, ionizing radiation (IR), resulting in acute toxicity of radiation-induced gastrointestinal syndrome (RIGS)...
  20. Organismal Radioprotection Through Pharmacological Quiescence
    JOHN S CHANT; Fiscal Year: 2010
    ..by applicant): Hematologic toxicity is a principal cause of morbidity and mortality after exposure to ionizing radiation (IR)...
  21. Regulation of the VDJ recombinase during genotoxic stress
    Karla K Rodgers; Fiscal Year: 2013
    ..In our preliminary studies using fluorescently tagged RAG proteins, we determined that DNA damage induced by ionizing radiation (IR) prompted a re-localization of the V(D)J recombinase in the cell, which in effect sequestered the enzyme ..
  22. Effect of bisphenol A exposure on mammary stem cell function and transformation
    Luzhe Sun; Fiscal Year: 2013
    ..that the transforming activity of BPA may be more evident in combination with a DNA damaging agent such as ionizing radiation, which is a known risk factor for breast cancer...
  23. Development of a Porcine Model of Ataxia-Telangiectasia
    Christopher Rogers; Fiscal Year: 2013
    ..brain tumors), immunodeficiency, insulin-resistant diabetes, chromosomal instability, sensitivity to ionizing radiation, susceptibility to bronchopulmonary disease, and the absence, or almost complete absence, of a thymus...
  24. The role of human DNA polymerase eta in the mutagenic response to oxidative stres
    SCOTT DAVID MCCULLOCH; Fiscal Year: 2013
    ..agents such as polycyclic aromatic hydrocarbons like dioxin, heavy metals, pesticides, and ultraviolet and ionizing radiation. Reactive oxygen species are created by normal cell processes and in elevated levels by oxidative stress...
  25. Imaging Strategies to Measure Brown Fat and Its Activity
    C Ronald Kahn; Fiscal Year: 2010
    ..However, PET/CT is expensive and requires ionizing radiation, making it unappealing for routine use and serial studies...
  26. Steroid-Based Contrast Agents for Magnetic Resonance Imaging of Endocrine Disease
    Thomas J Meade; Fiscal Year: 2013
    ..MRI does not use ionizing radiation or radioactivity like positron emission tomography (PET) and X-ray/CT, and it allows for 3D reconstructions ..
  27. FOXO1 Inhibition in Genotoxic Stress Response and Prostate Cancer Survival
    Haojie Huang; Fiscal Year: 2013
    ..Paradoxically, DNA damage-based therapy such as ionizing radiation is a standard treatment for localized PCa and yet treatment often fails and tumors eventually become drug/..
  28. Regulatory Functions of APE1 acetylation
    KISHOR KUMAR BHAKAT; Fiscal Year: 2013
    ..base excision repair (BER) pathway repairs damage caused by reactive oxygen species, alkylating agents and ionizing radiation, and so protects cells against the toxic effects of various endogenous and exogenous agents...
  29. Elucidating the in vivo Role of the p53 Apoptosis-Specific Target Gene Siva
    Jeanine L Frey; Fiscal Year: 2013
    ..on apoptosis levels in radiosensitive tissues known to display p53-dependent apoptosis following ionizing radiation. These studies will reveal the contexts in which Siva is important for p53-mediated apoptosis...
  30. ATF2 in DNA damage response.
    ZE apos EV A RONAI; Fiscal Year: 2010
    ..that ATM phosphorylates ATF2 on Ser490/8 following the formation of double-stranded DNA breaks (DSBs) by ionizing radiation (IR)...
  31. HIF-2alpha mediated mitophagy and lipogenesis in clear cell renal cell carcinoma
    Bo Qiu; Fiscal Year: 2013
    ..While HIF-2[unreadable] has been demonstrated to promote resistance to ionizing radiation-induced oxidative stress and apoptosis, the precise mechanism is not clear...
  32. ASCORBATE-INDUCED RADIOSENSITIZATION IN PANCREATIC CANCER
    Joseph J Cullen; Fiscal Year: 2013
    ..ascorbate as an adjuvant would be expected to sensitize pancreatic tumor cells to standard therapies such as ionizing radiation that increase levels of reactive oxygen species...
  33. The role of VEGF-C in resisting stress in prostate cancer
    Kaustubh Datta; Fiscal Year: 2013
    ..function of the VEGF-C/Neuropilin-2/m-TORC-2/AKT-1 axis in prostate cancer cells will be evaluated following ionizing radiation alone or in combination with androgen deprivation...
  34. Environmental and genetic regulation of copy number variation (CNV)
    THOMAS PETES; Fiscal Year: 2010
    ..cellular mechanisms linked to CNV formation, focusing on spontaneous events and those stimulated by low-dose ionizing radiation. We will determine the rates of CNV and the types of alterations in cells exposed to radiation at different ..
  35. Novel strategy to mitigate and treat radiation combined infection injury by targe
    Shyam Biswal; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The risk of civilians or emergency responders being exposed to ionizing radiation is high in scenarios of nuclear/radiological terrorism or accidents...
  36. Role of Genetic Susceptibility in Therapy-related Subsequent Malignancies
    Smita Bhatia; Fiscal Year: 2013
    ..g., chemotherapy and therapy-related leukemia;ionizing radiation and subsequent breast or thyroid cancer after Hodgkin lymphoma), there is considerable inter-individual ..
  37. Bioactive Peptides for Mitigation of AGS and Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ionizing radiation (IR) released by detonation can cause the most overwhelming disaster...
  38. Mechanisms of ATM activation
    Tanya T Paull; Fiscal Year: 2013
    ..occurs during DNA replication, as a result of damage from metabolic intermediates, and after exposure to ionizing radiation and radiomimetic compounds...
  39. LOCALIZED REVISION OF EPIGENETIC LANDSCAPES INDUCED BY DNA DOUBLE-STRAND BREAKS
    Barry P Sleckman; Fiscal Year: 2012
    ..HEALTH RELEVANCE: DNA double-strand breaks (DSBs) are generated upon exposure to genotoxic agents, such as ionizing radiation, and are intermediates during several important physiologic processes, including lymphocyte antigen receptor ..
  40. Soy isoflavones to augment radiotherapy of lung carcinoma
    Gilda G Hillman; Fiscal Year: 2012
    ..of natural soy isoflavones containing genistein, daidzein and glycitein can sensitize cancer cells to ionizing radiation by inhibiting pathways of cell survival which are constitutively activated in cancer cells and not in normal ..
  41. Analysis of Redox Modulated Signaling Networks in Response to Ionizing Radiation
    Cristina Furdui; Fiscal Year: 2013
    ..This proposal combines multiple sets of experimental data, modeling, and theory for developing a systems-level understanding of properties and biological consequences of these perturbations. ..
  42. XeBox-E10 Gas Polarizer for Functional MRI of Pediatric Lung Disease
    SEAN BEDILION FAIN; Fiscal Year: 2013
    ..fibrosis (CF) where X-ray CT and chest radiography have played an increasing role despite their use of ionizing radiation. Bronchopulmonary dysplasia (BPD), also diagnosed based on abnormal radiographic findings is a disease of ..
  43. Low-cost handheld medical device for neuroaxial anesthesia guidance in the obese
    FRANK WILLIAM MAULDIN; Fiscal Year: 2012
    ..Fluoroscopy lacks portability, has a higher cost, and exposes the patient to ionizing radiation. Recent studies have shown that conventional ultrasound improves success rates (e.g. 65% from 32%)...
  44. Rel B mediated-redox regulation of radiation therapy
    William H St Clair; Fiscal Year: 2013
    ..of oxidative stress and that reactive oxygen species (ROS) contribute importantly to the cytotoxic effect of ionizing radiation (IR)...
  45. Cell cycle checkpoint defects lead to chronic inflammation in RA
    Thomas M Aune; Fiscal Year: 2013
    ..g. smoking, UV or ionizing radiation, oxidative stress, chemical exposures, cell replication, inflammatory stress, or normal metabolic activities...
  46. Molecular mechanisms of GBM radioresistance and strategies for radiosensitization
    Sandeep Burma; Fiscal Year: 2013
    ..was improved, from approximately 6 months to 10-12 months, following near-maximal brain-tolerated doses of ionizing radiation. The central role that radiation plays in treating GBM is also illustrated by the landmark Stupp study ..
  47. Hyperpolarized 129-Xenon-based MRI Probes for Brain Injury
    JEREMY PHILLIP CELVER; Fiscal Year: 2010
    ..resolution (mm-cm) and use probes containing short-lived radioactive isotopes which emit tissue damaging ionizing radiation. MRI, on the other hand, utilizes relatively harmless radio-waves to image living organisms at close to ..
  48. Near-Infrared Fluorescent Choline Kinase Inhibitors for Cancer Imaging and Therap
    SEAN ARLAUCKAS; Fiscal Year: 2013
    ..optical imaging is a relatively inexpensive technique that employs sensitive tracers, without the use of ionizing radiation, to report specific molecular interactions in vivo...
  49. Reliable Evaluation of Coronary Artery Disease using Myocardial BOLD MRI with CO2
    Rohan Dharmakumar; Fiscal Year: 2013
    ..non-invasive;that is, in addition to avoiding the risks of cardiac catheterization, it would be free of ionizing radiation, exogenous contrast media, and pharmacological stress-agents with both risks and side effects...
  50. Assessment of lung function in neonates and infants
    IULIAN CONSTANTIN RUSET; Fiscal Year: 2013
    ..Since hyperpolarized gas MRI does not use ionizing radiation, it is well-suited for use in children and infants...
  51. Mechanisms for Transcription-Coupled Repair in Human Cells
    Priscilla K Cooper; Fiscal Year: 2010
    ..reactive oxygen species generated by the cellular metabolism as well as by environmental agents including ionizing radiation. The broad objective of this project is to elucidate both the molecular mechanisms for transcription-coupled ..
  52. CHROMATIN MODIFYING FACTORS CONTROL RADIATION RESPONSE AND GENOMIC STABILITY
    Tej K Pandita; Fiscal Year: 2013
    ..human ortholog of the Drosophila MOF gene (Males absent On the First) that interacts with and regulates the ionizing radiation (IR) response function of ATM...
  53. The molecular basis of RECQ4-associated genetic disorders and cancer predispositi
    Yilun Liu; Fiscal Year: 2013
    ..family is among the cancer suppressors linked to repairing lesions caused by DNA damaging agents, such as ionizing radiation and cisplatin...
  54. P53-dependent responses to toxicants in parous and nulliparous breast
    D Joseph Jerry; Fiscal Year: 2010
    ..strongest support for environmental carcinogenesis comes from mouse models showing that exposures such as ionizing radiation (IR) and polycyclic aromatic hydrocarbons (PAHs) increase mammary tumor formation...
  55. Foundations of Pretargeted Radioimmunotherapy
    KARL D WITTRUP; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Delivery of cell-killing doses of ionizing radiation to tumors is the objective of antibody-directed radioimmunotherapy (RIT)...
  56. AP Endonuclease 2 in hematopoietic stem cell maintenance
    Carol E Schrader; Fiscal Year: 2012
    ..I will test this hypothesis by exposing FACS-purified hematopoietic stem cells to increasing doses of ionizing radiation and assaying DNA damage, repair, and HSC function...
  57. Three-dimensional cardiac accelerometry for cardiac monitoring
    Michael J Russell; Fiscal Year: 2010
    ..as sensitive as ECHO, without the inherent dependence on operator proficiency, and 4) is independent of ionizing radiation. We hypothesized that measurement of cardiac accelerations within a defined frequency range, coupled to ..
  58. Pathway Choice of DNA Double-Strand Break Repair
    David J Chen; Fiscal Year: 2013
    ..caused by endogenous (byproducts of cellular metabolism and replication associated errors) and exogenous (ionizing radiation and chemotherapeutic drugs) agents...
  59. Genetics of the formation of repair &recombination foci
    RODNEY J ROTHSTEIN; Fiscal Year: 2013
    ..will permit a further glimpse into the in vivo action of key components of the cellular response to both ionizing radiation as well as spontaneous lesions...
  60. The Role of Peroxiredoxin1 &Reactive Oxygen Species in Breast Tumor Initiation
    Carola Anke Neumann; Fiscal Year: 2013
    ..This mouse model mimics conditions where H2O2 levels are elevated as found in aging, tobacco smoking, ionizing radiation and environmental carcinogens...
  61. 15th International Workshop on Ataxia-Telangiectasia and ATM to be held in India
    Tej K Pandita; Fiscal Year: 2012
    ..is characterized by a progressive cerebellar ataxia, telangiectasia, immunodeficiency, genomic instability, ionizing radiation sensitivity, and a markedly increased incidence of cancer...
  62. Cellular Responses to Radiation and Other Types of Damage
    Gray F Crouse; Fiscal Year: 2012
    ..is created by oxidative damage as a result of reactive oxygen species generated directly and indirectly by ionizing radiation. The experiments in this proposal are designed to increase understanding of the mechanisms by which ..
  63. Risk of Leukemia after Protracted Exposures to Low Doses of Ionizing Radiation
    LYDIA BOGDANIVNA ZABLOTSKA; Fiscal Year: 2013
    ..While the effects of high and moderate doses of ionizing radiation on leukemia have been shown in many studies, the effects of lower doses are not clear...
  64. CELLULAR AND MOLECULAR RESPONSE TO DNA REPAIR DEFICIENCY
    Renee Reijo Pera; Fiscal Year: 2000
    ..of this and other members of the XRCC class of DNA repair genes protects cells against the lethal effects of ionizing radiation and alkylating agents...
  65. RADIATION CYTOGENETICS
    Joel Bedford; Fiscal Year: 1993
    ..therapy by radiation, and oncogenesis that is the principal hazard to the human population from low level ionizing radiation exposure...
  66. METALS/NUCLEOSIDE HYDROPEROXIDE MEDIATED GENETIC DAMAGE
    Krystyna Frenkel; Fiscal Year: 1992
    ..Many exogeneous mutagens and carcinogens act through the generation of oxygen radicals as does ionizing radiation. In the presence of oxygen, various hydroperoxides are formed in DNA exposed to ionizing radiation...
  67. HE3 MR Diffusion & Low Dose CT Quantitation of Emphysema
    David Gierada; Fiscal Year: 2005
    ..However, CT is performed using relatively high doses of ionizing radiation, which limits its acceptability as a screening and follow-up test, particularly in early or mild disease...
  68. REGULATION OF P53 IN CERVICAL CARCINOMA BY HEAT/HYPOXIA
    Amato Giaccia; Fiscal Year: 1999
    ..investigate the differences and similarities between the modulation of wild-type p53 activity by hypoxia vs ionizing radiation, and 2) to explore the mechanism of genomic instability and apoptosis induced by hypoxia...
  69. Radiation and Genomic Instability in Finite Lifespan Human Mammary Epithelium
    Amy Kronenberg; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ionizing radiation was the first environmental mutagen identified by H.J. Muller in 1928, and radiation is a known human carcinogen...
  70. REPAIR OF OXIDATIVE AND RADIATION-INDUCED DNA DAMAGE
    PAUL DOETSCH; Fiscal Year: 1993
    ..A substantial body of evidence indicates that ionizing radiation- induced mutagenesis and carcinogenesis results from damage to DNA...
  71. FOOTPRINTING WITH IRON (II)-GENERATED HYDROXYL RADICAL
    THOMAS TULLIUS; Fiscal Year: 2003
    ..The hydroxyl radical also is produced by the interaction of ionizing radiation with water, and as such is the proximate chemical species that mediates radiation damage to DNA...
  72. Radiation Exposure from Medical Imaging: are Doses in the Carcinogenic Range?
    Rebecca Smith Bindman; Fiscal Year: 2009
    ..Therefore, along with the increased utilization of CT has come a marked increase in the medical exposure to ionizing radiation. Extensive epidemiological evidence has linked exposure to ionizing radiation with development of radiation-..
  73. IONIZING RADIATION MUTAGENESIS IN ESCHERICHIA COLI
    KENDRIC SMITH; Fiscal Year: 1990
    One important finding from our studies on ionizing radiation mutagenesis (IRM). In Escherichia coli is that IRM is not uniformly dependent on the umuDC genes as is the case for UV radiation mutagenesis...
  74. Planning Grant for a Study of the Effect of Radiation o*
    Camille Ragin; Fiscal Year: 2006
    There are several reports of studies that suggest an association between exposure to ionizing radiation and the subsequent development of breast cancer...
  75. PPK: Radiation Response and Cell Proliferation
    Peter Stambrook; Fiscal Year: 2006
    ..the controls that are attenuated or lost is the capacity to arrest cell cycle progression in response to ionizing radiation and consequent DNA damage or other insult to the cell...
  76. Gamma-ray-induced mutagen sensitivity in breast cancer
    Li E Wang; Fiscal Year: 2005
    ..abnormally high level of radiosensitivity as measured by the frequency of chromosomal aberrations induced by ionizing radiation exposure (such as X- and gamma-ray) in the G2 phase of PHA stimulated lymphocytes...