radiation

Summary

Summary: Emission or propagation of electromagnetic energy (waves/rays), or the waves/rays themselves; a stream of electromagnetic particles (electrons, neutrons, protons, alpha particles) or a mixture of these. The most common source is the sun.

Top Publications

  1. pmc A kinetic-based model of radiation-induced intercellular signalling
    Stephen J McMahon
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland, United Kingdom
    PLoS ONE 8:e54526. 2013
  2. pmc A gene transfer agent and a dynamic repertoire of secretion systems hold the keys to the explosive radiation of the emerging pathogen Bartonella
    Lionel Guy
    Department of Molecular Evolution, Cell and Molecular Biology, Science for Life Laboratory, Biomedical Centre, Uppsala University, Uppsala, Sweden
    PLoS Genet 9:e1003393. 2013
  3. pmc Radiation-induced gliomas
    Gautam Prasad
    University of California San Francisco, Helen Diller Family Cancer Center, Department of Radiation Oncology, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143 1708, USA
    Expert Rev Neurother 9:1511-7. 2009
  4. ncbi Radiation dose to patients from cardiac diagnostic imaging
    Andrew J Einstein
    Department of Medicine, Cardiology Division, Columbia University Medical Center, 622 W 168th St, PH 10 408, New York, NY 10032, USA
    Circulation 116:1290-305. 2007
  5. ncbi Molecular phylogeny and dating of an insular endemic moth radiation inferred from mitochondrial and nuclear genes: the genus Galagete (Lepidoptera: Autostichidae) of the Galapagos Islands
    Patrick Schmitz
    Department of Entomology, Muséum d Histoire Naturelle, C P 6434, CH 1211 Geneva 6, Switzerland
    Mol Phylogenet Evol 45:180-92. 2007
  6. ncbi Electromagnetic radiation from ingested sources in the human intestine between 150 MHz and 1.2 GHz
    Lawrence C Chirwa
    Micro Systems Technology Group, Department of Electronics and Electrical Engineering, Glasgow University, Rankine Bldg, Oakfield Avenue, Glasgow G12 8LT, U K
    IEEE Trans Biomed Eng 50:484-92. 2003
  7. pmc Radiation-suppressed plasmonic open resonators designed by nonmagnetic transformation optics
    Hongyi Xu
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore
    Sci Rep 2:784. 2012
  8. ncbi Influence of PAR and UV-A in determining plant sensitivity and photomorphogenic responses to UV-B radiation
    Donald T Krizek
    Climate Stress Laboratory, Natural Resources Institute, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705 2350, USA
    Photochem Photobiol 79:307-15. 2004
  9. ncbi Response to high LET radiation 12C (LET, 295 keV/microm) in M5 cells, a radio resistant cell strain derived from Chinese hamster V79 cells
    R Pathak
    Department of Biotechnology, West Bengal University of Technology, Salt Lake, Kolkata
    Int J Radiat Biol 83:53-63. 2007
  10. doi The impact of the International Atomic Energy Agency (IAEA) program on radiation and tissue banking in Peru
    Emma Castro Gamero
    Peruvian Institute of Nuclear Energy, Av Canada, 1470, Lima, Peru
    Cell Tissue Bank 10:167-71. 2009

Research Grants

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
  2. Lauren Endres; Fiscal Year: 2014
  3. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
  4. Sogol Mostoufi-Moab; Fiscal Year: 2016
  5. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
  6. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
  7. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
  8. ANTHONY JOHN KANAI; Fiscal Year: 2016
  9. Rac GTPase signaling during embryonic salivary gland branching morphogenesis
    Sharon Sequeira; Fiscal Year: 2012
  10. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012

Detail Information

Publications304 found, 100 shown here

  1. pmc A kinetic-based model of radiation-induced intercellular signalling
    Stephen J McMahon
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland, United Kingdom
    PLoS ONE 8:e54526. 2013
    ..The radiation-induced bystander effect is a prime example of this effect, where cells shielded from radiation exposure see a ..
  2. pmc A gene transfer agent and a dynamic repertoire of secretion systems hold the keys to the explosive radiation of the emerging pathogen Bartonella
    Lionel Guy
    Department of Molecular Evolution, Cell and Molecular Biology, Science for Life Laboratory, Biomedical Centre, Uppsala University, Uppsala, Sweden
    PLoS Genet 9:e1003393. 2013
    ..The process counters gene loss and forces all cells to contribute to the production of the GTA and the secreted molecules. The results advance our understanding of the role that GTAs play for the evolution of bacterial genomes...
  3. pmc Radiation-induced gliomas
    Gautam Prasad
    University of California San Francisco, Helen Diller Family Cancer Center, Department of Radiation Oncology, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143 1708, USA
    Expert Rev Neurother 9:1511-7. 2009
    b>Radiation-induced gliomas represent a relatively rare but an extensively published entity in the neuro-oncologic literature...
  4. ncbi Radiation dose to patients from cardiac diagnostic imaging
    Andrew J Einstein
    Department of Medicine, Cardiology Division, Columbia University Medical Center, 622 W 168th St, PH 10 408, New York, NY 10032, USA
    Circulation 116:1290-305. 2007
  5. ncbi Molecular phylogeny and dating of an insular endemic moth radiation inferred from mitochondrial and nuclear genes: the genus Galagete (Lepidoptera: Autostichidae) of the Galapagos Islands
    Patrick Schmitz
    Department of Entomology, Muséum d Histoire Naturelle, C P 6434, CH 1211 Geneva 6, Switzerland
    Mol Phylogenet Evol 45:180-92. 2007
    ..In order to better understand the diversification of this endemic insular radiation, to unravel relationships among species and populations, and to get insight into the early stages of speciation, ..
  6. ncbi Electromagnetic radiation from ingested sources in the human intestine between 150 MHz and 1.2 GHz
    Lawrence C Chirwa
    Micro Systems Technology Group, Department of Electronics and Electrical Engineering, Glasgow University, Rankine Bldg, Oakfield Avenue, Glasgow G12 8LT, U K
    IEEE Trans Biomed Eng 50:484-92. 2003
    ..The radiation characteristics of sources in the GI tract cannot be readily calculated due to the complexity of the human body ..
  7. pmc Radiation-suppressed plasmonic open resonators designed by nonmagnetic transformation optics
    Hongyi Xu
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore
    Sci Rep 2:784. 2012
    How to confine light energy associated with surface plasmon polaritons (SPPs) in a physical space with minimal radiation loss whereas creating maximum interacting section with surrounding environment is of particular interest in ..
  8. ncbi Influence of PAR and UV-A in determining plant sensitivity and photomorphogenic responses to UV-B radiation
    Donald T Krizek
    Climate Stress Laboratory, Natural Resources Institute, Agricultural Research Service, US Department of Agriculture, Beltsville, MD 20705 2350, USA
    Photochem Photobiol 79:307-15. 2004
    The role of photosynthetically active radiation (400-700 nm) (PAR) in modifying plant sensitivity and photomorphogenic responses to ultraviolet-B (280-320 nm) (UV-B) radiation has been examined by a number of investigators, but few ..
  9. ncbi Response to high LET radiation 12C (LET, 295 keV/microm) in M5 cells, a radio resistant cell strain derived from Chinese hamster V79 cells
    R Pathak
    Department of Biotechnology, West Bengal University of Technology, Salt Lake, Kolkata
    Int J Radiat Biol 83:53-63. 2007
    ..Additionally, the relative survival of these two cell lines was tested by the colony forming ability of the cells, with a view to understanding the mechanism of cellular damages that lead to difference in cell survival...
  10. doi The impact of the International Atomic Energy Agency (IAEA) program on radiation and tissue banking in Peru
    Emma Castro Gamero
    Peruvian Institute of Nuclear Energy, Av Canada, 1470, Lima, Peru
    Cell Tissue Bank 10:167-71. 2009
    ..Health Institute was inaugurated in 1996, with the financial and technical support of the IAEA program on radiation and tissue banking...
  11. doi Circadian variation in shedding of the oocysts of Isospora turdi (Apicomplexa) in blackbirds (Turdusmerula): an adaptative trait against desiccation and ultraviolet radiation
    G Martinaud
    Equipe Ecologie Evolutive, UMR CNRS 5561 Biogeosciences, Universite de Bourgogne, 6 Bd Gabriel, F 21000 Dijon, France
    Int J Parasitol 39:735-9. 2009
    ..This appears to be due to the effect of warmth and ultraviolet (UV) radiation with UVB waves being more damaging than UVA...
  12. doi Radiation physics
    Britt H Tonnessen
    Roper St Francis Heart and Vascular Center, Charleston, SC 29401, USA
    J Vasc Surg 53:6S-8S. 2011
    b>Radiation comes in different forms of energy in motion. Doses of radiation and the area of interest are important considerations when imaging patients, particularly during percutaneous procedures.
  13. doi Re-radiation enhancement in polarized surface-enhanced resonant Raman scattering of randomly oriented molecules on self-organized gold nanowires
    Barbara Fazio
    CNR IPCF Istituto per i Processi Chimico Fisici, Viale F Stagno d Alcontres 37, I 98156, Messina, Italy
    ACS Nano 5:5945-56. 2011
    We explore the effect of re-radiation in surface-enhanced Raman scattering (SERS) through polarization-sensitive experiments on self-organized gold nanowires on which randomly oriented Methylene Blue molecules are adsorbed...
  14. doi Public safety assessment of electromagnetic radiation exposure from mobile base stations
    Z O Alhekail
    Prince Sultan Advanced Technology Research Institute, King Saud University, Riyadh, Saudi Arabia
    J Radiol Prot 32:325-37. 2012
    Exposure of the general public to electromagnetic radiation originating from randomly selected GSM/WCDMA base stations in Riyadh, Kingdom of Saudi Arabia has been assessed in the context of the International Commission on Non-Ionising ..
  15. doi Radiation hazards in children - lessons from Chernobyl, Three Mile Island and Fukushima
    Shinji Fushiki
    Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokoji, Kajii cho 465, Kamigyo ku, Kyoto 602 8566, Japan
    Brain Dev 35:220-7. 2013
    ..The most critical issue when considering the effects of radiation on the health of children was the increase of thyroid cancer, as clearly demonstrated among people who were ..
  16. pmc ABT-737 induces Bim expression via JNK signaling pathway and its effect on the radiation sensitivity of HeLa cells
    Huan Wang
    Gynecology Department, Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    PLoS ONE 7:e52483. 2012
    ..In this study, we demonstrate that ABT-737 improved the radiation sensitivity of cervical cancer HeLa cells and thereby provoked cell apoptosis...
  17. pmc Phenotypic and Genetic Divergence among Poison Frog Populations in a Mimetic Radiation
    Evan Twomey
    Department of Biology, East Carolina University, Greenville, NC, USA
    PLoS ONE 8:e55443. 2013
    ..In a mimetic radiation, different populations of a species evolve to resemble different models, which can lead to speciation...
  18. pmc Inflammation and immunity in radiation damage to the gut mucosa
    Agnès François
    Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety, 31 Avenue de la Division Leclerc, 92262 Fontenay aux Roses, France
    Biomed Res Int 2013:123241. 2013
    Erythema was observed on the skin of the first patients treated with radiation therapy. It is in particular to reduce this erythema, one feature of tissue inflammation, that prescribed dose to the tumor site started to be fractionated...
  19. doi Diversification of Fijian halictine bees: insights into a recent island radiation
    Scott V C Groom
    School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia
    Mol Phylogenet Evol 68:582-94. 2013
    Although bees form a key pollinator suite for flowering plants, very few studies have examined the evolutionary radiation of non-domesticated bees over human time-scales...
  20. ncbi Stereotactic radiosurgery: adjacent tissue injury and response after high-dose single fraction radiation: Part I--Histology, imaging, and molecular events
    Bryan C Oh
    Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Neurosurgery 60:31-44; discussion 44-5. 2007
    ..The second article in the series begins by discussing strategies for radiosurgical therapeutic enhancement. It concludes by focusing on strategies for mitigation and repair of radiation-induced brain injury.
  21. ncbi Cytoprotective efficacy of amifostine against radiation- induced rectal toxicity: objective and subjective grading scales for radiomucositis
    Vassilis E Kouloulias
    Kapodistrian University, 2nd Radiology Department, Medical School, Attikon University Hospital, Rimini 1, Xaidari, Greece
    Molecules 13:892-903. 2008
    Curative radiation therapy of pelvic malignancies, frequently results in dose limiting toxicities such as serous, mucoid, or more rarely, bloody diarrhea...
  22. pmc Comparison of radiation exposure in lumbar pedicle screw placement with fluoroscopy vs computer-assisted image guidance with intraoperative three-dimensional imaging
    Harvey E Smith
    Thomas Jefferson University, Department of Orthopaedic Surgery, Philadelphia, PA 19107, USA
    J Spinal Cord Med 31:532-7. 2008
    Little is known about the long-term effects of chronic exposure to ionizing radiation. Studies have shown that spine surgeons may be exposed to significantly more radiation than that observed in surgery on the appendicular skeleton...
  23. doi Radiation damage in biomimetic dye molecules for solar cells
    Peter L Cook
    Department of Physics, University of Wisconsin Madison, 1150 University Ave, Madison, Wisconsin 53706, USA
    J Chem Phys 131:214702. 2009
    A significant obstacle to organic photovoltaics is radiation damage, either directly by photochemical reactions or indirectly via hot electrons...
  24. doi Effects of (56)Fe radiation on hippocampal function in mice deficient in chemokine receptor 2 (CCR2)
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Brain Res 246:69-75. 2013
    ..CCR2 KO and wild-type mice were used to compare effects of (56)Fe radiation (600MeV, 0...
  25. ncbi On radiation hormesis expressed in the immune system
    Shu Zheng Liu
    Department of Radiation Biology, Jilin University Norman Bethune Medical Center, 8 Xinmin Street, Changchun 130021, China
    Crit Rev Toxicol 33:431-41. 2003
    b>Radiation hormesis is reviewed with emphasis on its expression in the immune system...
  26. ncbi The relationship between temporal variation of hypoxia, polarographic measurements and predictions of tumour response to radiation
    Iuliana Toma-Daşu
    Department of Radiation Sciences, Umea University, S 901 85 Umea, Sweden
    Phys Med Biol 49:4463-75. 2004
    ..Indeed, the change in time of the acute hypoxic region does not compensate for the lack of oxygenation at a specific moment and therefore does not influence the polarographic oxygen measurements...
  27. ncbi Maternal effects of the scid mutation on radiation-induced transgenerational instability in mice
    T Hatch
    Department of Genetics, University of Leicester, Leicester, UK
    Oncogene 26:4720-4. 2007
    ....
  28. ncbi Assessment of near-future policy instruments for oceangoing shipping: impact on atmospheric aerosol burdens and the earth's radiation budget
    Axel Lauer
    International Pacific Research Center, University of Hawaii, 1680 East West Road, Honolull, Hawaii 96822, USA
    Environ Sci Technol 43:5592-8. 2009
    ..aerosol and cloud microphysics to study the impact of shipping on tropospheric aerosol burdens, clouds, and the radiation budget for four near-future ship emission policy scenarios for the year 2012...
  29. doi The yield of radiation-induced micronuclei in early and late-arising binucleated cells depends on radiation quality
    Christian Johannes
    Department of Genetics, University of Duisburg Essen, Germany
    Mutat Res 701:80-5. 2010
    ..time of human peripheral blood lymphocytes on the yield of chromosomal aberrations induced by sparsely ionising radiation in the G0 phase of the cell cycle...
  30. doi Radiation exposure does not significantly contribute to the risk of recurrence of Chernobyl thyroid cancer
    Pavel O Rumyantsev
    Department of Radiosurgery, Medical Radiological Research Center of Russian Academy of Medical Sciences, Obninsk 249036, Russian Federation
    J Clin Endocrinol Metab 96:385-93. 2011
    ..Long-term results of treatment are not well known, especially in comparison with sporadic PTC...
  31. doi A study of neurotoxic biomarkers, c-fos and GFAP after acute exposure to GSM radiation at 900 MHz in the picrotoxin model of rat brains
    M Carballo-Quintás
    Morphological Sciences Department, University of Santiago de Compostela, Santiago de Compostela, Spain
    Neurotoxicology 32:478-94. 2011
    ..of microwave exposure from the Global System for Mobile Communication (GSM) were studied in rats, using 900MHz radiation at an intensity similar to mobile phone emissions...
  32. ncbi The effects of antioxidants on radiation-induced apoptosis pathways in TK6 cells
    Ayelet M Samuni
    Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1002, USA
    Free Radic Biol Med 37:1648-55. 2004
    This study was designed to determine if radiation-mediated activation of the apoptotic pathways would be influenced by antioxidants and if a correlation would be found between radioprotection and changes in transduction pathways...
  33. pmc Radiation damage effects at four specimen temperatures from 4 to 100 K
    Benjamin E Bammes
    National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Struct Biol 169:331-41. 2010
    b>Radiation damage is the primary factor that limits resolution in electron cryo-microscopy (cryo-EM) of frozen-hydrated biological samples...
  34. doi Some considerations for mass casualty management in radiation emergencies
    Michael Hopmeier
    Unconventional Concepts Inc, 4075 Wilson Blvd, Ste 200, Arlington, VA 22203, USA
    Health Phys 98:790-4. 2010
    b>Radiation emergencies are rather new to humankind, as compared to other types of emergencies such as earthquakes, floods, or hurricanes...
  35. pmc Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells
    Leonid Gorelik
    Biogen Inc, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Exp Med 198:937-45. 2003
    ..The results revealed that BAFF production by radiation-resistant stromal cells is completely sufficient to provide a necessary signal for B cell survival/maturation, ..
  36. pmc Exposure to cell phone radiation up-regulates apoptosis genes in primary cultures of neurons and astrocytes
    Tian Yong Zhao
    Department of Anatomy and Neurobiology, 800 Rose St, University of Kentucky, Lexington, KY 40536 0298, USA
    Neurosci Lett 412:34-8. 2007
    The health effects of cell phone radiation exposure are a growing public concern...
  37. ncbi The alkaline Comet assay as biomarker in assessment of DNA damage in medical personnel occupationally exposed to ionizing radiation
    Vera Garaj-Vrhovac
    Laboratory of Mutagenesis, Institute for Medical Research and Occupational Health, HR 10 000 Zagreb, Croatia
    Mutagenesis 18:265-71. 2003
    The alkaline Comet assay was selected as a biomarker of exposure to evaluate the ongoing exposure to ionizing radiation of 50 medical workers occupationally exposed to ionizing radiation and 50 corresponding unexposed control subjects...
  38. ncbi Exposure to 50 Hz electromagnetic radiation promote early maturation and differentiation in newborn rat cerebellar granule neurons
    A Lisi
    Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy
    J Cell Physiol 204:532-8. 2005
    ..All these results indicate that exposure to non-ionizing radiations contribute to a premature expression of GluRs reducing the life span of CGN, leading to a more rapid cell maturation...
  39. doi Changes in MicroRNA expression patterns in human fibroblasts after low-LET radiation
    Olivier C Maes
    Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky 40292, USA
    J Cell Biochem 105:824-34. 2008
    Exposure to radiation provokes cellular responses controlled in part by gene expression networks. MicroRNAs (miRNAs) are small non-coding RNAs which mostly regulate gene expression by degrading the messages or inhibiting translation...
  40. pmc Radiation produces differential changes in cytokine profiles in radiation lung fibrosis sensitive and resistant mice
    Xiaoping Ao
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA
    J Hematol Oncol 2:6. 2009
    Recent research has supported that a variety of cytokines play important roles during radiation-induced lung toxicity...
  41. doi An update on three radiation accidents in South America
    Nelson José de Lima Valverde
    Hygia Integral Occupational and Safety Health, Rio de Janeiro, Brazil
    Health Phys 98:868-71. 2010
    ..purpose of this review is to analyze the long term health and other effects of accidental exposures to ionizing radiation in order to extract lessons from these radiological emergencies that might be useful for avoiding similar events ..
  42. pmc Synchrotron radiation X-ray microfluorescence reveals polarized distribution of atomic elements during differentiation of pluripotent stem cells
    Simone C Cardoso
    Instituto de Fisica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 6:e29244. 2011
    ..state towards neural differentiated state through analysis of trace elements distribution using the Synchrotron Radiation X-ray Fluorescence Spectroscopy...
  43. ncbi The interaction between Terahertz radiation and biological tissue
    S W Smye
    Department of Medical Physics and Engineering, Leeds Teaching Hospitals NHS Trust, UK
    Phys Med Biol 46:R101-12. 2001
    Terahertz (THz) radiation occupies that region of the electromagnetic (EM) spectrum between approximately 0.3 and 20 THz...
  44. ncbi An introduction to medical imaging with coherent terahertz frequency radiation
    A J Fitzgerald
    Academic Unit of Medical Physics and Centre of Medical Imaging Research, University of Leeds, UK
    Phys Med Biol 47:R67-84. 2002
    Methods have recently been developed that make use of electromagnetic radiation at terahertz (THz) frequencies, the region of the spectrum between millimetre wavelengths and the infrared, for imaging purposes...
  45. ncbi The magnitude of radiation force on ultrasound contrast agents
    Paul A Dayton
    Department of Biomedical Engineering, University of California, Davis 95616, USA
    J Acoust Soc Am 112:2183-92. 2002
    ..photography of insonified bubbles with a time resolution of 10 ns allows observations of translation due to radiation force, in addition to the visualization of radial oscillations...
  46. pmc Cancer risks following diagnostic and therapeutic radiation exposure in children
    Ruth A Kleinerman
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, EPS 7044, 6120 Executive Blvd, Rockville, MD 20852, USA
    Pediatr Radiol 36:121-5. 2006
    ..increasing use and complexity of these procedures comes concern about the cancer risk associated with ionizing radiation exposure to children...
  47. ncbi Convergence, constraint and the role of gene expression during adaptive radiation: floral anthocyanins in Aquilegia
    Justen B Whittall
    Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, CA 93106, USA
    Mol Ecol 15:4645-57. 2006
    ..These patterns support the hypothesis that rapid evolutionary change occurs largely through regulatory rather than structural mutations...
  48. ncbi Adding synchrotron radiation to infrared microspectroscopy: what's new in biomedical applications?
    Paul Dumas
    SOLEIL Synchrotron, L Orme des Merisiers, BP48, F 91191 Gif sur Yvette Cedex, France
    Trends Biotechnol 25:40-4. 2007
    ..Although the theory of infrared (IR) spectroscopy is thoroughly worked out, the scientific ground of vibrational spectroscopy is now undergoing a real boost, with the application of this analytical technique in biology and biomedicine...
  49. ncbi Melatonin attenuates radiation-induced learning deficit and brain oxidative stress in mice
    Kailash Manda
    National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Acta Neurobiol Exp (Wars) 67:63-70. 2007
    ..The present study, therefore, aimed to investigate the protective effect of melatonin against radiation-induced impairment in the learning ability of mice. Twenty days oral administration of melatonin (0.1 mg/kg b.w...
  50. pmc Effects of computer monitor-emitted radiation on oxidant/antioxidant balance in cornea and lens from rats
    Mehmet Balci
    Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Department of Ophthalmology, Ankara, Turkey
    Mol Vis 15:2521-5. 2009
    This study aims to investigate the possible effects of computer monitor-emitted radiation on the oxidant/antioxidant balance in corneal and lens tissues and to observe any protective effects of vitamin C (vit C).
  51. doi Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers
    Antonello E Spinelli
    Medical Physics Department, San Raffaele Scientific Institute, Via Olgettina N 60, Milan, Italy
    Phys Med Biol 55:483-95. 2010
    In this paper, we showed that Cerenkov radiation (CR) escaping from the surface of small living animals injected with (18)F-FDG can be detected with optical imaging techniques...
  52. pmc Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition
    Søren M Johnson
    Department of Genetics, The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 120:2528-36. 2010
    ..due to the sensitivity of proliferating hematopoietic stem/progenitor cells (HSPCs) to ionizing radiation (IR). No effective therapy exists to mitigate the hematologic toxicities of TBI...
  53. pmc Suppression of uPAR retards radiation-induced invasion and migration mediated by integrin β1/FAK signaling in medulloblastoma
    Arun Kumar Nalla
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
    PLoS ONE 5:e13006. 2010
    ..Here, we attempt to capitalize on the radiation-induced aggressive behavior of medulloblastoma cells by comparing the extracellular protease activity and the ..
  54. doi Extremophiles: from abyssal to terrestrial ecosystems and possibly beyond
    Francesco Canganella
    Department of Agrobiology and Agrochemistry, University of Tuscia, via C De Lellis, 01100, Viterbo, Italy
    Naturwissenschaften 98:253-79. 2011
    ..In some cases (DNA polymerase, thermostable enzymes), the search was successful and the final application was achieved, but certainly further exploitations are next to come...
  55. doi Molecular responses of brain endothelial cells to radiation in a mouse model
    Shinuo Liu
    Neuroscience Research Australia, University of New South Wales, New South Wales, Australia
    J Clin Neurosci 19:1154-8. 2012
    ..Elucidating the molecular effects of radiation on EC may allow development of new therapies that modulate the response of AVM to radiation...
  56. pmc Material properties from acoustic radiation force step response
    Marko Orescanin
    Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Acoust Soc Am 125:2928-36. 2009
    ..An acoustic radiation force is applied to deform the gel locally while Doppler pulses track the induced movement...
  57. ncbi Parental occupational exposures to electromagnetic fields and radiation and the incidence of neuroblastoma in offspring
    A J De Roos
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Epidemiology 12:508-17. 2001
    We examined parental occupational exposures to electromagnetic fields and radiation and the incidence of neuroblastoma in offspring...
  58. ncbi Effects of electromagnetic radiation from a cellular telephone on the oxidant and antioxidant levels in rabbits
    M Kemal Irmak
    Department of Biochemistry, Faculty of Medicine, Inonu University, 44069 Malatya, Turkey
    Cell Biochem Funct 20:279-83. 2002
    The number of reports on the effects induced by electromagnetic radiation (EMR) in various cellular systems is still increasing. Until now no satisfactory mechanism has been proposed to explain the biological effects of this radiation...
  59. ncbi An adaptive radiation model for the origin of new gene functions
    M Pilar Francino
    Evolutionary Genomics Department, DOE Joint Genome Institute and Genomics Division, Lawrence Berkeley National Laboratory, 2800 Mitchell Dr, Walnut Creek, California, USA
    Nat Genet 37:573-7. 2005
    ....
  60. ncbi Radiation
    John W Burnham
    Environmental Health and Radiation Safety, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Crit Care Clin 21:785-813, vii-viii. 2005
    ..reviews basic radiobiology and the variety of clinical signs and symptoms exhibited by victims exposed to radiation. Preparation for patient receipt and emergency care, followed by definitive diagnosis using biodosimetry is also ..
  61. ncbi Guard cells in albino leaf patches do not respond to photosynthetically active radiation, but are sensitive to blue light, CO2 and abscisic acid
    M Rob G Roelfsema
    Molecular Plant Physiology and Biophysics, Julius von Sachs Institute for Biosciences, Biocenter, Wurzburg University, Germany
    Plant Cell Environ 29:1595-605. 2006
    ..specific and involves phototropins, while the second pathway mediates a response to photosynthetically active radiation (PAR)...
  62. ncbi Unique molecular characteristics of radiation-induced glioblastoma
    Andrew M Donson
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    J Neuropathol Exp Neurol 66:740-9. 2007
    b>Radiation-induced glioblastomas (RIGs) represent a significant proportion of glioblastomas (GBMs) seen in children and young adults and manifest poor prognosis...
  63. pmc Human-mediated emergence as a weed and invasive radiation in the wild of the CD genome allotetraploid rice species (Oryza, Poaceae) in the Neotropics
    Gerard Second
    UMR DIAPC, IRD, Montpellier, France
    PLoS ONE 3:e2613. 2008
    ....
  64. doi Radiation-induced micronucleus formation and DNA damage in human lymphocytes and their prevention by antioxidant thiols
    Prabha Tiwari
    Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
    Mutat Res 676:62-8. 2009
    ..of antioxidant thiols, namely N-acetyl cysteine (NAC), glutathione (GSH) and thioproline (TP), on gamma radiation-induced damage to human lymphocytes DNA as assessed by micronucleus (MN) formation and comet assay parameters...
  65. ncbi Enhancement of radiation-inducible hepatic glutathione-S-transferases Ya, Yb1, Yb2, Yc1, and Yc2 gene expression by oltipraz: possible role in radioprotection
    S G Kim
    College of Pharmacy, Duksung Women s University, Seoul, Korea
    Mol Pharmacol 51:225-33. 1997
    Previous studies have shown that radiation in combination with oltipraz enhances hepatic microsomal epoxide hydrolase expression...
  66. ncbi A radiation hybrid framework map of bovine chromosome 13
    J Schlapfer
    Institute of Animal Breeding, University of Berne, Switzerland
    Chromosome Res 5:511-9. 1997
    In this paper we present a 5000-rad radiation hybrid framework map of bovine chromosome 13 (BTA13) containing 13 loci, including five conserved genes and eight polymorphic microsatellites...
  67. ncbi Adaptive radiation in a heterogeneous environment
    P B Rainey
    Department of Plant Sciences, University of Oxford, UK
    Nature 394:69-72. 1998
    ..The effects of adaptive radiation are often seen, but the underlying causes are difficult to disentangle and remain unclear...
  68. ncbi The U.S. National Research Council's views of the radiation hazards in space
    R B Setlow
    Biology Department, Brookhaven National Laboratory, Box 5000, Upton, NY 11973 5000, USA
    Mutat Res 430:169-75. 1999
    The author was the Chairman of a Task Group on the Biological Effects of Space Radiation formed as a result of discussions between NASA and the U.S...
  69. ncbi The two-stage clonal expansion model as an example of a biologically based model of radiation-induced cancer
    W F Heidenreich
    GSF Institute of Radiation Protection, 85758 Neuherberg, Germany
    Radiat Res 156:678-81. 2001
    ..Applications of the TSCE model to data sets for animals and humans for particle radiation (alpha particles) are presented...
  70. pmc Calcium protects differentiating neuroblastoma cells during 50 Hz electromagnetic radiation
    R Tonini
    Dipartimento di Fisiologia e Biochimica Generali, , I-20133 Milano, Italy
    Biophys J 81:2580-9. 2001
    Despite growing concern about electromagnetic radiation, the interaction between 50- to 60-Hz fields and biological structures remains obscure...
  71. pmc The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution
    Frédérique Mégnin-Chanet
    U 350 INSERM, Institut Curie Recherche, Centre Universitaire, Orsay, France
    BMC Pharmacol 2:2. 2002
    ..a non-peptidomimetic farnesyltransferase inhibitor, was investigated without or with combined exposure to ionizing radiation in three human tumor cell lines (HCT-116, MiAPaCa-2 and A-549) bearing a point mutation in the K-Ras gene.
  72. ncbi Hepatocellular carcinoma among atomic bomb survivors: significant interaction of radiation with hepatitis C virus infections
    Gerald B Sharp
    Department of Epidemiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima, 732 0815 Japan
    Int J Cancer 103:531-7. 2003
    ..the cohort of Japanese survivors of the 1945 atomic bombings to study the joint effects of HBV and HCV with radiation on the risk of HCC...
  73. ncbi In vivo study of human skin using pulsed terahertz radiation
    E Pickwell
    Semiconductor Physics Group, Cavendish Laboratory, Cambridge University, Madingley Road, Cambridge CB3 0HE, UK
    Phys Med Biol 49:1595-607. 2004
    ..devised a finite difference time-domain (FDTD) model which is able to closely simulate the interaction of THz radiation with water...
  74. ncbi Breast tomography with synchrotron radiation: preliminary results
    Silvia Pani
    Department of Physics, University of Trieste, INFN, Trieste Section, Via Valerio 2, I 34126 Trieste, Italy
    Phys Med Biol 49:1739-54. 2004
    A system for in vivo breast imaging with monochromatic x-rays has been designed and built at the synchrotron radiation facility Elettra in Trieste (Italy) and will be operational in 2004...
  75. ncbi Phosphatidylinositide 3-kinase/AKT in radiation responses
    M Zhan
    State Key Laboratory of Experimental Hematology, Institute of Hematology, National Research Center of Stem Cell Engineering and Technology, Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Tianjin, China
    Histol Histopathol 19:915-23. 2004
    Ionizing or ultraviolet radiation-induced cellular survival signaling pathways induce development of cancer and insensitivity of tumor cells to radiation therapy...
  76. ncbi Acute exposure to 930 MHz CW electromagnetic radiation in vitro affects reactive oxygen species level in rat lymphocytes treated by iron ions
    Marek Zmyslony
    Physical Hazards Department, Nofer Institute of Occupational Medicine, Lodz, Poland
    Bioelectromagnetics 25:324-8. 2004
    ..Exposures to electromagnetic radiation (power density 5 W/m2, theoretical calculated SAR = 1.5 W/kg) were performed within a GTEM cell...
  77. ncbi Oxidative damage in the kidney induced by 900-MHz-emitted mobile phone: protection by melatonin
    Faruk Oktem
    Department of Pediatric Nephrology, School of Medicine, Suleyman Demirel University, Isparta, Turkey
    Arch Med Res 36:350-5. 2005
    The mobile phones emitting 900-MHz electromagnetic radiation (EMR) may be mainly absorbed by kidneys because they are often carried in belts...
  78. ncbi Radiation exposure to the surgeon during fluoroscopically assisted percutaneous vertebroplasty: a prospective study
    Roger Harstall
    Department of Orthopaedic Surgery, Inselspital, University of Berne, Switzerland
    Spine (Phila Pa 1976) 30:1893-8. 2005
    ..A prospective case control study design was conducted...
  79. ncbi Stable loss of global DNA methylation in the radiation-target tissue--a possible mechanism contributing to radiation carcinogenesis?
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Alta, Canada
    Biochem Biophys Res Commun 337:526-33. 2005
    b>Radiation-induced lymphomagenesis and leukemogenesis are complex processes involving both genetic and epigenetic changes...
  80. ncbi Energy dependence of response of new high sensitivity radiochromic films for megavoltage and kilovoltage radiation energies
    Sou Tung Chiu-Tsao
    Radiation Oncology Department, Beth Israel Medical Center and St Luke s Roosevelt Hospital Center, New York, New York 10003, USA
    Med Phys 32:3350-4. 2005
    ..We determined the dose response curves of these films for four different radiation sources, namely, 6 MV photon beams (6 MVX), Ir-192, I-125, and Pd-103...
  81. ncbi Applications of ultrasound streaming and radiation force in biosensors
    Larisa A Kuznetsova
    School of Biosciences, Cardiff University, Main Building, Park Place, Cardiff CF10 3TL, UK
    Biosens Bioelectron 22:1567-77. 2007
    Direct radiation force (DRF) and acoustic streaming provide the main influences on the behaviour of particles in aqueous suspension in an ultrasound standing wave (USW)...
  82. pmc Consistency in electronic portal imaging registration in prostate cancer radiation treatment verification
    Eric Berthelet
    Radiation Therapy Program, Vancouver Island Centre, British Columbia Cancer Agency, Victoria, BC, Canada
    Radiat Oncol 1:37. 2006
    A protocol of electronic portal imaging (EPI) registration for the verification of radiation treatment fields has been implemented at our institution...
  83. ncbi The radiation-induced block in spermatogonial differentiation is due to damage to the somatic environment, not the germ cells
    Zhen Zhang
    Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    J Cell Physiol 211:149-58. 2007
    b>Radiation and chemotherapeutic drugs cause permanent sterility in male rats, not by killing most of the spermatogonial stem cells, but by blocking their differentiation in a testosterone-dependent manner...
  84. pmc Evolution of a tumorigenic property conferred by glycophosphatidyl-inositol membrane anchors of carcinoembryonic antigen gene family members during the primate radiation
    Fakhraddin Naghibalhossaini
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    Mol Biol Cell 18:1366-74. 2007
    ..one package found in many primates, including humans, and a second, novel package found only in the Cebidae radiation of New World monkeys, give rise to efficiently processed GPI-linked proteins...
  85. ncbi Residual late radiation damage in mouse stromal tissue assessed by the tumor bed effect
    Jaap Haveman
    Academic Medical Centre, University of Amsterdam Laboratory for Experimental Oncology and Radiobiology LEXOR, Department of Radiotherapy, The Netherlands
    J Radiat Res 48:107-12. 2007
    ..This effect is called Tumor Bed Effect (TBE) and can be used to assess the sensitivity of stromal tissue to radiation. We tested the ability of stromal tissue to recover from X-ray-induced damage as a function of the time interval ..
  86. ncbi Intestinal epithelial cell dysfunction is mediated by an endothelial-specific radiation-induced bystander effect
    Marie Helene Gaugler
    IRSN, DRPH, SRBE, LRPAT, Fontenay aux Roses, F 92260 France
    Radiat Res 167:185-93. 2007
    The response of endothelial cells (EC) to high radiation doses leads to damage of normal tissue or tumor. The precise mechanisms of the endothelial-tissue linkage are still largely unknown...
  87. ncbi Radiation-induced apoptosis in retinal progenitor cells is p53-dependent with caspase-independent DNA fragmentation
    Karl Heinz Herzog
    Institute for Genetics, University of Stuttgart Hohenheim, Garbenstrasse 30, D 70599 Stuttgart, Germany
    Eur J Neurosci 25:1349-56. 2007
    ....
  88. ncbi Comparison of bioactivity between GSM 900 MHz and DCS 1800 MHz mobile telephony radiation
    Dimitris J Panagopoulos
    Department of Cell Biology and Biophysics, University of Athens Athens Greece
    Electromagn Biol Med 26:33-44. 2007
    An increasing number of studies find that pulsed Radio Frequency (RF), electromagnetic radiation of both systems of digital mobile telephony, established and commonly used in Europe during the last years, GSM 900 MHz (Global System for ..
  89. ncbi The small-animal radiation research platform (SARRP): dosimetry of a focused lens system
    Hua Deng
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, MD, USA
    Phys Med Biol 52:2729-40. 2007
    A small animal radiation platform equipped with on-board cone-beam CT and conformal irradiation capabilities is being constructed for translational research...
  90. ncbi Fielding a current idea: exploring the public health impact of electromagnetic radiation
    Stephen J Genuis
    Faculty of Medicine, University of Alberta, 2935 66 Street, Edmonton, AB, Canada T6K 4C1
    Public Health 122:113-24. 2008
    ..scientific literature have raised concern about the individual and public health impact of adverse non-ionizing radiation (a-NIR) from electromagnetic field (EMF) exposure emanating from certain power, electrical and wireless devices ..
  91. ncbi Effect of UV-B and high visual radiation on photosynthesis in freshwater (nostoc spongiaeforme) and marine (Phormidium corium) cyanobacteria
    Rupali Bhandari
    Department of Botany, Goa University, Goa 403 206, India
    Indian J Biochem Biophys 44:231-9. 2007
    Human activity is causing depletion of ozone in stratosphere, resulting in increased UV-B radiation and global warming. However, impact of these climatic changes on the aquatic organism (especially marine) is not fully understood...
  92. ncbi Alteration of apoptotic signaling molecules as a function of time after radiation in human neuroblastoma cells
    Natarajan Aravindan
    OUPB 1430, Department of Radiation Oncology, College of Medicine, University of Oklahoma Health Sciences Center, 825 North East 10th Street, Oklahoma City, OK 73104, USA
    Mol Cell Biochem 310:167-79. 2008
    ..Serum-starved human SK-N-MC cells were exposed to low linear energy transfer (LET) radiation (2 Gy) and incubated for 15, 30, 45 min, and 48 h...
  93. doi The VUV electronic spectroscopy of acetone studied by synchrotron radiation
    M Nobre
    Laboratório de Colisões Atómicas e Moleculares, Departamento de Fisica, CEFITEC, Universidade Nova de Lisboa, 2829 516, Caparica, Portugal
    Phys Chem Chem Phys 10:550-60. 2008
    ..590 eV). Rydberg orbitals of each series have been classified according to the magnitude of the quantum defect (delta) and are extended to higher quantum numbers than in the previous analyses...
  94. doi Radiation risks from imaging studies in children with cancer
    Elizabeth Robbins
    Pediatric Hematology Oncology, University of California, San Francisco, Box 0106, San Francisco, California 94143, USA
    Pediatr Blood Cancer 51:453-7. 2008
    Individuals exposed to high doses of ionizing radiation are known to be at risk of developing cancer. Recent reviews about the late effects of ionizing radiation indicate that even low doses of radiation can cause cancer...
  95. doi Progress in research on radiation combined injury in China
    Zhongmin Zou
    Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing, China
    Radiat Res 169:722-9. 2008
    The significant feature of radiation combined injury is the occurrence of a combined effect...
  96. pmc HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair
    Thuy T Koll
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Mol Cancer Ther 7:1985-92. 2008
    ..We found that HSP90 inhibitor, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (DMAG), is synergistic with radiation for non-small cell lung cancer cell lines, NCI-H460 and A549...
  97. doi Effects of exposure to a mobile phone on testicular function and structure in adult rabbit
    Nader Salama
    Department of Urology, Tokushima School of Medicine, Tokushima, Japan
    Int J Androl 33:88-94. 2010
    The accumulating effects of exposure to electromagnetic radiation emitted by a conventional mobile phone (standby position) on the testicular function and structure are not yet fully investigated...
  98. doi Radiation-guided targeting of combretastatin encapsulated immunoliposomes to mammary tumors
    Christopher B Pattillo
    Department of Mechanical Engineering, Temple University, 1947 N 12th St, Philadelphia, Pennsylvania 19122, USA
    Pharm Res 26:1093-100. 2009
    b>Radiation upregulates expression of endothelial cell adhesion molecules providing a potential avenue for targeting drugs to irradiated tissue. Induced upregulation of E-selectin can be used to target immunoliposomes to solid tumors...
  99. doi Risk of radiation and choice of imaging
    Hans Herfarth
    Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Dig Dis 27:278-84. 2009
    ..The cancer risk associated with diagnostic procedures employing radiation has been receiving increasing attention over the last few years...
  100. doi Spatiotemporal analysis of DNA repair using charged particle radiation
    F Tobias
    GSI Helmholtzzentrum fur Schwerionenforschung, Biophysik, Planckstrasse 1, D 64291 Darmstadt, Germany
    Mutat Res 704:54-60. 2010
    ..With the help of the microbeam, geometrical patterns of traversing ions can be applied facilitating the analysis of spatial organisation of repair...
  101. ncbi Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation
    Takeshi Kuribayashi
    Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki 300 0394, Japan
    Int J Mol Med 25:25-9. 2010
    ..the ability of scriptaid, a novel HDAC inhibitor and trichostatin A (TSA) to enhance cell killing by radiation in radioresistant SQ-20B cells derived from human head and neck squamous carcinoma...

Research Grants87

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. Lauren Endres; Fiscal Year: 2014
    ..known to cause a predisposition to cancer development as well as hypersensitivity to ultraviolet and ionizing radiation [1-3]...
  3. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..levels of TxRd1 have been associated with poor prognosis due to enhanced cellular resistance to chemo- and radiation therapy...
  4. Sogol Mostoufi-Moab; Fiscal Year: 2016
    ..review), and a second study examining skeletal complications of growth hormone therapy in cancer survivors after radiation compared to children treated with growth hormone for idiopathic growth hormone deficiency (manuscript in ..
  5. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..Alterations in lysophospholipid metabolism and signaling also contribute to drug and radiation resistance, tumor angiogenesis, and progression of many cancer types including ovarian, breast, prostate, ..
  6. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
    ..b>Radiation dose is carefully monitored and controlled for all equipment at all sites...
  7. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
    ..b>Radiation dose is carefully monitored and controlled for all equipment at all sites...
  8. ANTHONY JOHN KANAI; Fiscal Year: 2016
    ..is a key therapy for treating these malignancies, the dose is limited by the potential for developing radiation cystitis...
  9. Rac GTPase signaling during embryonic salivary gland branching morphogenesis
    Sharon Sequeira; Fiscal Year: 2012
    ..of: 1) Sjogren's Syndrome, an autoimmune disease that targets saliva-secreting acinar tissue, 2) radiation and chemotherapeutic regimens for head and neck cancers and 3) adverse side effects from thousands of ..
  10. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The toxicity of ionizing radiation (IR) in mammals is largely due to damage to the most radiosensitive tissues, the gastrointestinal (GI) tract and the hematopoietic (HP) system...
  11. ANIL KUMAR JAISWAL; Fiscal Year: 2014
    ..PUBLIC HEALTH RELEVANCE: INrf2 study is of considerable importance in prevention of xenobiotic, nutrient and radiation-induced oxidative stress...
  12. SPEAKER TRAVEL AND SCIENTIFIC SESSION SUPPORT FOR THE TERATOLOGY SOCIETY 50TH
    Christina Chambers; Fiscal Year: 2011
    ..The program contains eight special lectures. The Robert L. Brent Lecture will explore aspects of Radiation Exposure to the Embryo and Child, including aspects of the 60-year follow-up study of radiation exposure in ..
  13. Xianglin Shi; Fiscal Year: 2015
    ..provided by applicant): Epidemiological, clinical, and laboratory studies have implicated that ultraviolet radiation (UV) is a complete environmental carcinogen and that repeated exposures can lead to the development of melanoma ..
  14. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    ..Moreover, the genetic instability of the somatic cells in the FA patient means that exposure to ionizing radiation, environmental carcinogens and chemotherapeutic agents pose unique risks to the patient...
  15. JAMES M COGHILL; Fiscal Year: 2015
    ..HSCT involves the administration of chemotherapy and/or radiation to patients, followed by the transplant of hematopoietic stem cells from a sibling or unrelated matched donor...
  16. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    THOMAS EDWARD WILSON; Fiscal Year: 2010
    ..and folate stress, which inhibit replication through different mechanisms than aphidicolin, and on ionizing radiation and bleomycin, which lead directly to DNA DSBs...
  17. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ..propose to validate a bioassay using mammary gland in organ culture exposed to genotoxic agents (we will use radiation and doxorubicin, but this assay could be adapted for other genotoxic agents of interest)...
  18. Ted A Bateman; Fiscal Year: 2015
    ..In our preclinical models, ionizing radiation rapidly activated osteoclastic bone resorption and caused a decline in trabecular-bone volume fraction of 20-30% ..
  19. DNA Damage Checkpoint and Cancer
    Toru Ouchi; Fiscal Year: 2012
    ..explore the signal transduction mechanisms involved in BAAT1/ATM activation after DNA damage induced by ionizing radiation (IR) and chemicals, and examine how BAAT1/ATM pathway functions together with other checkpoint proteins such as ..
  20. David E Fisher; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Fatigue occurs in up to 80% of cancer patients undergoing radiation or chemotherapy and is significantly debilitating. Our lab studies skin signaling which mediates UV induced pigmentation...
  21. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..utilizes a novel type of chemical sterilization called S-59 that results in DNA crosslinks when exposed to UVA radiation. We and others have successfully used this technology to develop safe and effective recombinant bacterial ..
  22. Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrial
    Lynn Harrison; Fiscal Year: 2013
    ..Tumor cells living in low oxygen microenvironments are more resistant to radiotherapy. Combining cisplatin with radiation has improved cell killing, but cisplatin is very toxic and tumors can become resistant to cisplatin during ..
  23. 14th International Workshop on Ataxia-Telangiectasia and ATM
    Richard A Gatti; Fiscal Year: 2010
    ..that is characterized by a progressive cerebellar ataxia, telangiectasia, immunodeficiency, genomic instability, radiation sensitivity, and a markedly increased incidence of cancer, usually lymphoma or leukemia...
  24. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2011
    ..Chernobyl had risen by 2 orders of magnitude, most likely as a consequence of increased exposure to ionizing radiation. The routes and mechanisms by which radiation generated these additional thyroid cancers remain mysterious...
  25. Hematopoietic Stem Cells (HSCs) as Juvenile Protective Factors that Alter Aging
    David E Harrison; Fiscal Year: 2011
    ..ST-HSCs and CMPs from B6 and BALB mice will be exposed to treatments that cause genomic instability: gamma radiation, DNA polymerase inhibition, and paraquat...
  26. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Ionizing irradiation-induced pulmonary damage limits effective radiation dose escalation in the treatment of lung and esophageal cancer...
  27. Beta 2-Microglobulin signaling and targeting in bone metastasis
    Leland W K Chung; Fiscal Year: 2013
    ..mechanisms and combinatorial approach achieving synergism between anti-b2-M monoclonal antibody (mAb) plus radiation as a promising therapeutic regimen for prostate cancer bone metastases...
  28. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..study will validate the use of fMRI alone in young high risk populations unable to undergo PET studies involving radiation and pharmacological challenges...
  29. Evaluating the role of histone H3K79 methylation states in DNA damage repair in S
    Jeffrey S Thompson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ultraviolet (UV) radiation poses a serious threat to human health through its damaging effects on DNA...
  30. PKC delta and cell renewal in irradiated taste epithelium
    MARY ELAINE REYLAND; Fiscal Year: 2012
    ..preliminary data favor the hypothesis that proliferating taste bud progenitor cells are the direct targets of radiation damage...
  31. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..Despite technological advances in neurosurgery, chemotherapy and radiation therapy, the prognosis for patients with these tumors remains variable and is relatively poor in infants and ..
  32. Michael J Smerdon; Fiscal Year: 2014
    ..We will use UV radiation and DNA methylating chemicals as prototype environmental agents for studies on nucleotide excision repair (NER) ..
  33. GEORGE NORBERT COX; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Development of radiological/nuclear medical countermeasures to treat Acute Radiation Syndrome (ARS) is a high priority research area for NIAID...
  34. The role of LKB1 in the maintenance of genomic stability.
    Zhi Xiang Xu; Fiscal Year: 2013
    ..LKB1-deficient cells exhibit a delayed DDR and reduced DNA repair after exposure to ionizing radiation (IR)...
  35. Oliver W Press; Fiscal Year: 2014
    ..In Aim 3 we will characterize and maximize the myelosuppressive and immunosuppressive effects of radiation delivered to lymphohematopoietic tissues via either 90Y- or 177Lu-labeled biotin (as determined from aim 1) in ..
  36. ANASTACIA GRIEGO; Fiscal Year: 2016
    ..cells, leading to recovered p53 and pRb activity, which could render cells more susceptible to chemotherapy and radiation. We expect to determine how AP-1 transcription factors regulate HPV replication in infected cells that maintain ..
  37. Preclinical testing of a novel PDK1 inhibitor for treating vestibular schwannoma
    Abraham Jacob; Fiscal Year: 2013
    ..Current treatment options are surgery and/or radiation;however, complications remain major concerns...
  38. WADE HAMPTON MARTIN; Fiscal Year: 2014
    ..information equivalent to non-selective pharmacologic MPI at a fraction of the cost, time expenditure, radiation exposure, and institutional equipment and personnel resource requirements in patients who cannot perform ..
  39. Zbigniew Darzynkiewicz; Fiscal Year: 2014
    ..DDR in response to different types of DNA damage will be assessed including that caused by drugs, mutagens and radiation, and correlated with cell cycle phase and induction of apoptosis...
  40. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2013
    ..The incidence of HCC is on the rise in USA, with little hope for cure or treatment through chemotherapy, radiation or other traditional cancer treatments...
  41. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2011
    ..by applicant): Free radicals play a major role in human diseases such as iron sulfate poisoning, ionizing radiation, oxygen toxicity in premature infants treated with hyperbaric oxygen, ultraviolet radiation-induced cancer and ..
  42. Novel Hematopoietic Conditioning Agents for Treatment of Hematological Diseases
    Olga B Chernova; Fiscal Year: 2010
    ..Unfortunately, conditioning drugs and radiation are not specific for the hematopoietic system or cancer cells but also damage normal tissues (e.g...
  43. Human in Mouse Modeling of HNSCC to Predict Resonse to Therapy
    Wendell G Yarbrough; Fiscal Year: 2010
    ..Treatment includes at least two and at times all three modalities of surgery, radiation, and chemotherapy...
  44. Imaging of Aortic Atherosclerosis and Inflammation in the Metabolic Syndrome
    Warren J Manning; Fiscal Year: 2012
    ..of CMR for providing information regarding plaque components, including inflammation in a non-ionizing radiation environment and in the absence of iodinated contrast...
  45. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2012
    ..by applicant): Free radicals play a major role in human diseases such as iron sulfate poisoning, ionizing radiation, oxygen toxicity in premature infants treated with hyperbaric oxygen, ultraviolet radiation-induced cancer and ..
  46. Edward A Neuwelt; Fiscal Year: 2015
    ..Treatment paradigms will be whole brain radiation therapy with or without temozolomide chemotherapy, and bevacizumab (Avastin), a monoclonal antibody against ..
  47. Stem Cell Based Therapy For Radiation Induced Gastrointestinal Syndrome
    Chandan Guha; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Radiation-induced gastrointestinal syndrome (RIGS) results from a combination of direct cytocidal effects on intestinal crypt and endothelial cells and subsequent loss of the mucosal barrier, ..
  48. GM-CSF analogs for treating acute radiation syndrome
    GEORGE NORBERT COX; Fiscal Year: 2010
    Development of radiological/nuclear medical countermeasures to treat Acute Radiation Syndrome (ARS) is a high priority research area for NIAID...
  49. Effect Ultraviolet Radiation on Latent M. tuberculosis Infection in Guinea Pigs
    Amminikutty Jeevan; Fiscal Year: 2010
    ..There is compelling evidence that ultraviolet radiation (UVR) causes immune suppression in both humans and experimental animals...
  50. Ke Jian Liu; Fiscal Year: 2016
    ..of arsenic can amplify the DNA damaging and carcinogenic potential of other genotoxic agents such as ultraviolet radiation, at least in part, through inhibition of DNA repair processes...
  51. Development of a Porcine Model of Ataxia-Telangiectasia
    Christopher Rogers; Fiscal Year: 2011
    ..brain tumors), immunodeficiency, insulin-resistant diabetes, chromosomal instability, sensitivity to ionizing radiation, susceptibility to bronchopulmonary disease, and the nearly complete absence of a thymus...
  52. Caveolins in the Pathogenesis of Idiopathic Pulmonary Fibrosis
    Dan N Predescu; Fiscal Year: 2010
    ..It was shown that the levels of caveolin 1 (cav-1) are decreased in type I epithelial cells after radiation-induced lung injury, as well as in a model of bleomicin induced pulmonary fibrosis...
  53. Organismal Radioprotection Through Pharmacological Quiescence
    JOHN S CHANT; Fiscal Year: 2010
    ..by applicant): Hematologic toxicity is a principal cause of morbidity and mortality after exposure to ionizing radiation (IR)...
  54. A reconstructed skin model for development of treatments for albinism
    Seth J Orlow; Fiscal Year: 2010
    ..results from the failure of melanocytes to produce melanin which protects the skin against ultraviolet radiation (UV) induced damage and reduces the risk of cutaneous cancers...
  55. Regulation of the VDJ recombinase during genotoxic stress
    Karla K Rodgers; Fiscal Year: 2013
    ..preliminary studies using fluorescently tagged RAG proteins, we determined that DNA damage induced by ionizing radiation (IR) prompted a re-localization of the V(D)J recombinase in the cell, which in effect sequestered the enzyme ..
  56. Montaser Shaheen; Fiscal Year: 2014
    ..provided by applicant): DNA damage is the principle mechanism of activity of most chemotherapeutic and radiation treatments given to patients with hematologic malignancies...
  57. Luzhe Sun; Fiscal Year: 2016
    ..the transforming activity of BPA may be more evident in combination with a DNA damaging agent such as ionizing radiation, which is a known risk factor for breast cancer...
  58. Underserved Men's Understanding of Androgen Deprivation Therapy Related Risks
    Sally L Maliski; Fiscal Year: 2012
    ..therapy (ADT) is increasingly being used to treat prostate cancer in the neoadjuvant and adjuvant contexts with radiation therapy (RT), for recurrence following primary treatment with surgery or radiation, or when the prostate cancer ..
  59. JONATHAN EDWARD MCCONATHY; Fiscal Year: 2015
    ..click the click reaction for in vivo PET imaging of cationic AA transport, tumor proliferation and response to radiation therapy...
  60. Keiko Hirose; Fiscal Year: 2016
    ..We will also use radiation bone marrow chimeras to isolate the effects of CD36 expression on leukocytes versus cochlear supporting cells...
  61. Investigating the role of interleukin-22 in thymus function
    Jarrod Dudakov; Fiscal Year: 2013
    ..of immune competence following infection, shock or common cancer therapies such as cytoreductive chemo- or radiation therapy. Thymic regenerative capacity diminishes with age and remains a poorly understood area...
  62. QUYNH THU XUAN LE; Fiscal Year: 2016
    ..These studies will help to establish that Gal-1 is a novel target that can be used in conjunction with RT to improve the treatment outcome in NSCLC. ..
  63. Marcel R m van den Brink; Fiscal Year: 2016
    ..function that allows for renewal of immune competence following infection, shock, cytoreductive chemo- or radiation therapy and other causes of thymic injury...
  64. A Pilot Study of Yoga for Breathing and Quality of Life of Lung Cancer Patients
    JUDITH MARIE FOULADBAKHSH; Fiscal Year: 2013
    ..Patients with bone metastasis, cognitive impairment, severe respiratory problems and/or receiving radiation will be excluded. An estimated 3-4 patients per month will be enrolled over a two-year period...
  65. EFFECTS OF GAMMA RADIATION ON BIOMEDICAL POLYMERS
    Cato Laurencin; Fiscal Year: 1990
    The objective of this grant proposal is to conduct studies exploring the effects of therapeutic ionizing radiation on polymeric material implants...
  66. Bioactive Peptides for Mitigation of AGS and Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ionizing radiation (IR) released by detonation can cause the most overwhelming disaster...
  67. FDG-PET and V/Q SPECT Acquired During Radiation to Predict Outcomes in Lung Cance
    Feng Ming Kong; Fiscal Year: 2009
    ..Although surgery provides the best chance of cure, the majority of NSCLC require radiation for treatment...
  68. Ultrasound guided site-specific gene delivery in prostate cancer
    Pier Paolo Claudio; Fiscal Year: 2010
    ..Additionally, this proposal aims at improving the response of prostate cancer to radiation therapy...
  69. INTRACAVITARY HYPERTHERM & RADIATN OF ESOPHAGEAL CANCER
    C Chou; Fiscal Year: 1993
    ..investigated mostly for superficial tumors and has been found to be efficacious, especially in combination with radiation or chemotherapy...
  70. Improving Gastrointestinal Recovery after Radiation
    George Georges; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The gastrointestinal (GI) tract is highly sensitive to radiation damage. Substantial injury to the GI tract after radiation exposure results in death...
  71. Hyperbaric O2 Stimulation of Salivary Flow in Radiation -induced Xerostomia
    Michael Martin; Fiscal Year: 2009
    ..oxygen therapy (HBO2) therapy may significantly and permanently increase salivary flow in patients who have radiation-induced xerostomia, and who receive HBO2 as treatment or preventatively for osteoradionecrosis, or for head and ..
  72. Nanotechnology enabled desktop image-guided microbeam radiation therapy system
    OTTO Z contact ZHOU; Fiscal Year: 2010
    ..For these patients radiation needed to eradicate radioresistant tumor can cause intolerable or fatal radiation damage to normal tissue...
  73. Mesenchymal Stem Cells To Mitigate and Treat Cutaneous Injury Following Radiation
    William H McBride; Fiscal Year: 2010
    Loss of skin barrier function can dramatically increase morbidity and mortality from radiation exposure in a nuclear accident, attack, or terrorist incident...
  74. The pigmentary system: securing a place in the sun
    Andrzej Slominski; Fiscal Year: 2009
    ..cells and malignant transformation, to the environmental effects on pigmentation including the effect of solar radiation, health disparities and pigmentary disorders, inheritance of skin coloration and sociobiology...
  75. A Phase II Study to Test the Correlation of a Radiation Pneumonitis Imaging Bioma
    Thomas M Guerrero; Fiscal Year: 2010
    ..to develop the first meaningful objective radiographic parameter that correlates with the clinical symptoms of radiation pneumonitis (RP) as an imaging biomarker of RP...
  76. Glutathione reductase and tumor sensitivity to radiation
    Xiangming Guan; Fiscal Year: 2003
    Cancer resistance to radiation is often the cause of failure in radiotherapy; intracellular glutathione (GSH) has been implicated as one of the major causes of the resistance...
  77. Protection against radiation-induced damage to intestinal nutrient transport
    Roger Howell; Fiscal Year: 2009
    ..The radiation exposures may be delivered acutely or chronically, by external or internal sources, and by low- and high-linear ..
  78. Radiation and Genomic Instability in Finite Lifespan Human Mammary Epithelium
    Amy Kronenberg; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ionizing radiation was the first environmental mutagen identified by H.J. Muller in 1928, and radiation is a known human carcinogen...
  79. Treatment with KZ-41 and OTP promotes wound healing in a radiation combined injur
    MOSTAFA GABER; Fiscal Year: 2009
    ..weapons or civilians in a nuclear attack, the majority of the survivors will most likely suffer from combined radiation and mechanical, vascular, or thermal injury...
  80. INTERSTITIAL NEUTRON THERAPY FOR GLIOBLASTOMA
    ALFRED YOUNG; Fiscal Year: 1991
    Human glioblastoma multiforme (GBM) responds poorly to currently available treatment. Other than surgery, radiation is the only method of treatment that significantly increases survival...
  81. Oral Interleukin 11 as a Countermeasure against Radiation Injury to Gut
    Alexander Burnett; Fiscal Year: 2009
    Countermeasures against radiation effects on the gastrointestinal tract due to a nuclear injury are essential to improve survival in case of such an injury...
  82. Inhibition of the SDF-1/CXCR4 axis as preventive therapy for radiation-induced pu
    HUI KUO contact SHU; Fiscal Year: 2010
    Many patients with intrathoracic malignancies will receive radiation therapy for the treatment for their disease. This often necessitates exposure of significant portions of their lung to high doses of radiation...
  83. Radiation Combined Injury: Mechanisms and Therapeutic Approaches
    Ping Wang; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): In the terrorist radiation exposure scenario, radiation victims likely suffer from additional injuries such as infection and sepsis...
  84. REPAIR OF OXIDATIVE AND RADIATION-INDUCED DNA DAMAGE
    PAUL DOETSCH; Fiscal Year: 1993
    The biological consequences of oxidative and radiation-induced DNA damage include cell death, mutation and neoplastic transformation...