partial pressure

Summary

Top Publications

  1. pmc Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology
    Thomas G Smith
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Med 3:e290. 2006
  2. pmc In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure
    Yu Wang
    Department of Biomedical Engineering, Washington University in St Louis, Campus Box 1097, One Brookings Drive, St Louis, Missouri 63130 4899, USA
    Opt Lett 36:1029-31. 2011
  3. ncbi Oxygen supply in aquatic ectotherms: partial pressure and solubility together explain biodiversity and size patterns
    Wilco C E P Verberk
    Marine Biology and Ecology Research Centre, School of Marine Science and Engineering, University of Plymouth, Davy Building, Drake Circus, Plymouth PL48AA, United Kingdom
    Ecology 92:1565-72. 2011
  4. pmc The partial pressure of resting end-tidal carbon dioxide predicts major cardiac events in patients with systolic heart failure
    Ross Arena
    Department of Physical Therapy, Virginia Commonwealth University, Health Sciences Campus, Richmond, VA 23298 0224, USA
    Am Heart J 156:982-8. 2008
  5. ncbi Oxygen, a source of life and stress
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    FEBS Lett 581:3582-91. 2007
  6. ncbi Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    D Fukumura
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 61:6020-4. 2001
  7. ncbi Transcutaneous monitoring of partial pressure of carbon dioxide in the elderly patient: a prospective, clinical comparison with end-tidal monitoring
    Andrea Casati
    Department of Anesthesia and Pain Therapy, University of Parma, and Ospedale Maggiore di Parma, Via Gramsci 14, 43100 Parma, Italy
    J Clin Anesth 18:436-40. 2006
  8. pmc The increase in pulmonary arterial pressure caused by hypoxia depends on iron status
    Thomas G Smith
    Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    J Physiol 586:5999-6005. 2008
  9. ncbi Respiratory sinus arrhythmia. A phenomenon improving pulmonary gas exchange and circulatory efficiency
    J Hayano
    Third Department of Internal Medicine, Nagoya City University Medical School, Japan
    Circulation 94:842-7. 1996
  10. ncbi A novel technique to follow fast PaO2 variations during experimental CPR
    Annette Herweling
    Department of Anesthesiology, Johannes Gutenberg University, Medical School, Langenbeckstrasse 1, D 55131 Mainz, Germany
    Resuscitation 65:71-8. 2005

Detail Information

Publications275 found, 100 shown here

  1. pmc Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology
    Thomas G Smith
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Med 3:e290. 2006
    ..This study investigated patients with Chuvash polycythaemia in order to analyse the role of the VHL-HIF pathway in systemic human cardiopulmonary physiology...
  2. pmc In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure
    Yu Wang
    Department of Biomedical Engineering, Washington University in St Louis, Campus Box 1097, One Brookings Drive, St Louis, Missouri 63130 4899, USA
    Opt Lett 36:1029-31. 2011
    ..fluorescence confocal microscopy (FCM) to noninvasively image hemoglobin oxygen saturation (sO₂) and oxygen partial pressure (pO₂) in vivo in single blood vessels with high spatial resolution...
  3. ncbi Oxygen supply in aquatic ectotherms: partial pressure and solubility together explain biodiversity and size patterns
    Wilco C E P Verberk
    Marine Biology and Ecology Research Centre, School of Marine Science and Engineering, University of Plymouth, Davy Building, Drake Circus, Plymouth PL48AA, United Kingdom
    Ecology 92:1565-72. 2011
    ..Physiologists emphasize oxygen partial pressure, while ecologists emphasize oxygen solubility, traditionally expressing oxygen in terms of concentrations...
  4. pmc The partial pressure of resting end-tidal carbon dioxide predicts major cardiac events in patients with systolic heart failure
    Ross Arena
    Department of Physical Therapy, Virginia Commonwealth University, Health Sciences Campus, Richmond, VA 23298 0224, USA
    Am Heart J 156:982-8. 2008
    The resting partial pressure of end-tidal carbon dioxide (Petco2) has been shown to reflect cardiac performance in acute care settings in patients with heart failure (HF)...
  5. ncbi Oxygen, a source of life and stress
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    FEBS Lett 581:3582-91. 2007
    ..In this review, we will introduce aspects of the physiology and biology of oxygen partial pressure and the molecular mechanisms implicated in oxygen sensing...
  6. ncbi Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    D Fukumura
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 61:6020-4. 2001
    ..However, the relationship between tissue oxygen partial pressure (pO(2))/pH and VEGF transcription in vivo is not known...
  7. ncbi Transcutaneous monitoring of partial pressure of carbon dioxide in the elderly patient: a prospective, clinical comparison with end-tidal monitoring
    Andrea Casati
    Department of Anesthesia and Pain Therapy, University of Parma, and Ospedale Maggiore di Parma, Via Gramsci 14, 43100 Parma, Italy
    J Clin Anesth 18:436-40. 2006
    To evaluate the accuracy and precision of estimation of partial pressure of carbon dioxide (Pa(CO2)) using end-tidal or transcutaneous CO2 (TcP(CO2)) measurements during mechanical ventilation in the elderly patient.
  8. pmc The increase in pulmonary arterial pressure caused by hypoxia depends on iron status
    Thomas G Smith
    Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    J Physiol 586:5999-6005. 2008
    ..Further research should investigate the potential for therapeutic manipulation of iron status in the management of hypoxic pulmonary hypertensive disease...
  9. ncbi Respiratory sinus arrhythmia. A phenomenon improving pulmonary gas exchange and circulatory efficiency
    J Hayano
    Third Department of Internal Medicine, Nagoya City University Medical School, Japan
    Circulation 94:842-7. 1996
    ..We hypothesized that RSA benefits pulmonary gas exchange by matching perfusion to ventilation within each respiratory cycle...
  10. ncbi A novel technique to follow fast PaO2 variations during experimental CPR
    Annette Herweling
    Department of Anesthesiology, Johannes Gutenberg University, Medical School, Langenbeckstrasse 1, D 55131 Mainz, Germany
    Resuscitation 65:71-8. 2005
    ..This study describes several validation experiments of this new device in vitro, and reports its first use during cardiopulmonary resuscitation in an animal model of cardiac arrest...
  11. pmc CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure
    Michael Fiegl
    Department of Molecular Hematology and Therapy and Stem Cell Transplantation and Cellular Therapy and Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 113:1504-12. 2009
    ..Hy-poxia increases CXCR4 in several tumor models, but the impact of reduced O(2) partial pressure (pO(2)) on expression and biologic function of CXCR4 in AML is unknown...
  12. ncbi Single-acquisition sequence for the measurement of oxygen partial pressure by hyperpolarized gas MRI
    M C Fischer
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 52:766-73. 2004
    ..Numerical simulations of the time evolution of the oxygen concentration were performed. Simulation results are presented to support the experimental data. Various parameter regimes were experimentally and numerically investigated...
  13. ncbi Effect on partial pressure of oxygen in arterial blood in percutaneous vertebroplasty
    A Uemura
    Department of Radiology, St Luke s International Hospital, Tokyo, Japan
    AJNR Am J Neuroradiol 28:567-9. 2007
    The purpose of this study is to estimate the change in partial pressure of oxygen (Pao(2)) during percutaneous vertebroplasty and also to examine the factors related to the change in Pao(2).
  14. ncbi Exercise ventilation inefficiency and cardiovascular mortality in heart failure: the critical independent prognostic value of the arterial CO2 partial pressure
    Marco Guazzi
    Cardiopulmonary Laboratory, Cardiology Division, University of Milano, San Paolo Hospital, Via A Di Rudini, 8, 20142, Milano, Italy
    Eur Heart J 26:472-80. 2005
    ..Ve/Vco(2) slope determinants are the dead space-tidal volume (Vd/Vt) ratio and the arterial CO(2) partial pressure (Paco(2)). We aimed at defining the respective prognostic role of these two variables.
  15. ncbi (3)he-MRI-based measurements of intrapulmonary p(O2) and its time course during apnea in healthy volunteers: first results, reproducibility, and technical limitations
    A J Deninger
    Department of Physics, University of Mainz, Staudingerweg 7, D 55099 Mainz, Germany
    NMR Biomed 13:194-201. 2000
    We applied a recently developed method of following the time course of the intrapulmonary oxygen partial pressure p(O2)(t) during apnea by (3)He MRI to healthy volunteers...
  16. pmc Pilot study assessment of dynamic vascular changes in breast cancer with near-infrared tomography from prospectively targeted manipulations of inspired end-tidal partial pressure of oxygen and carbon dioxide
    Shudong Jiang
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:76011. 2013
    The dynamic vascular changes in the breast resulting from manipulation of both inspired end-tidal partial pressure of oxygen and carbon dioxide were imaged using a 30 s per frame frequency-domain near-infrared spectral (NIRS) tomography ..
  17. pmc Extent to which pulmonary vascular responses to PCO2 and PO2 play a functional role within the healthy human lung
    Keith L Dorrington
    Department of Physiology, Anatomy and Genetics, Sherrington Bldg, Parks Road, University of Oxford, Oxford, OX1 3PT, UK
    J Appl Physiol (1985) 108:1084-96. 2010
    ..65), the response to CO2 dominates. The values for E suggest that the pulmonary vascular responses to both CO2 and O2 play a significant role in ventilation-perfusion matching in the healthy human lung...
  18. ncbi A flowing liquid test system for assessing the linearity and time-response of rapid fibre optic oxygen partial pressure sensors
    R Chen
    Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Respir Physiol Neurobiol 183:100-7. 2012
    ..by means of a system of rapid cross-over solenoid valves exposing the sensor to an abrupt change in oxygen partial pressure, P O2...
  19. ncbi Increasing arterial oxygen partial pressure during cardiopulmonary resuscitation is associated with improved rates of hospital admission
    Walter Spindelboeck
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Resuscitation 84:770-5. 2013
    ....
  20. ncbi Impact of dissolved hydrogen partial pressure on mixed culture fermentations
    Stefan de Kok
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands
    Appl Microbiol Biotechnol 97:2617-25. 2013
    ..mixed culture fermentations is that the NADH/NAD(+) ratio is directly coupled to the dissolved hydrogen partial pressure (pH2, liquid)...
  21. ncbi Transcutaneous carbon dioxide monitoring accurately predicts arterial carbon dioxide partial pressure in patients undergoing prolonged laparoscopic surgery
    Qingsheng Xue
    Department of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197, No 2 Ruijin Road, Shanghai 200025, P R China
    Anesth Analg 111:417-20. 2010
    There may be large differences between measurements of end-tidal carbon dioxide partial pressure (Petco(2)) and arterial carbon dioxide partial pressure (Paco(2)) during laparoscopic surgeries...
  22. ncbi Association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post-cardiac arrest syndrome
    Brian W Roberts
    Department of Emergency Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ 08103, USA
    Circulation 127:2107-13. 2013
    b>Partial pressure of arterial CO2 (Paco(2)) is a regulator of cerebral blood flow after brain injury...
  23. ncbi Soil carbon dioxide partial pressure and dissolved inorganic carbonate chemistry under elevated carbon dioxide and ozone
    N J Karberg
    USDA Forest Service, North Central Research Station, 410 MacInnes Drive, Houghton, MI 49931, USA
    Oecologia 142:296-306. 2005
    ..The effects of multiple air pollutants can alter belowground C allocation, leading to changes in the partial pressure of CO(2) (pCO(2)) in the soil , chemistry of dissolved inorganic carbonate (DIC) and the rate of mineral ..
  24. pmc Cerebral oxygenation in awake rats during acclimation and deacclimation to hypoxia: an in vivo electron paramagnetic resonance study
    Jeff F Dunn
    Department of Radiology, Experimental Imaging Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    High Alt Med Biol 12:71-7. 2011
    ..5 to 3 days. These data indicate that exposure to hypoxia results in significant improvements in steady-state oxygenation for a given inspired O(2) and that both acclimation and deacclimation can occur within days...
  25. ncbi Differences in mortality based on worsening ratio of partial pressure of oxygen to fraction of inspired oxygen corrected for immune system status and respiratory support
    Lachlan F Miles
    Alfred Hospital, Melbourne, Vic, Australia
    Crit Care Resusc 14:25-32. 2012
    ....
  26. ncbi 19F-MRI of perflubron for measurement of oxygen partial pressure in porcine lungs during partial liquid ventilation
    Simone Laukemper-Ostendorf
    Department of Radiology, Johannes Gutenberg University, Mainz, Germany
    Magn Reson Med 47:82-9. 2002
    A method for in vivo measurement of oxygen partial pressure (pO2) in porcine lungs during partial liquid ventilation (PLV) with perflubron (PFOB) was developed...
  27. pmc Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depression
    Sava Sakadzic
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Appl Opt 48:D169-77. 2009
    We developed a novel imaging technique that provides real-time two-dimensional maps of the absolute partial pressure of oxygen and relative cerebral blood flow in rats by combining phosphorescence lifetime imaging with laser speckle ..
  28. pmc Nutrient availability and atmospheric CO2 partial pressure modulate the effects of nutrient heterogeneity on the size structure of populations in grassland species
    Fernando T Maestre
    Department of Biology, Duke University, Phytotron Building, Box 90340, Durham, NC 27708, USA
    Ann Bot 98:227-35. 2006
    ..a) nutrient heterogeneity promotes size-asymmetric competition; and (b) nutrient heterogeneity interacts with both atmospheric CO2 partial pressure (P(CO2)) and nutrient availability to determine the magnitude of this response.
  29. pmc A method for measuring brain partial pressure of oxygen in unanesthetized unrestrained subjects: the effect of acute and chronic hypoxia on brain tissue PO(2)
    E Ortiz-Prado
    Department of Radiology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Neurosci Methods 193:217-25. 2010
    ..Tissue partial pressure of oxygen (PtO(2)) is influenced by the use of anesthesia or restraint...
  30. ncbi Contrasting effects of lower body positive pressure on upper airways resistance and partial pressure of carbon dioxide in men with heart failure and obstructive or central sleep apnea
    Takatoshi Kasai
    Sleep Research Laboratory of the Toronto Rehabilitation Institute, University of Toronto, Toronto, Ontario, Canada
    J Am Coll Cardiol 61:1157-66. 2013
    ..displacement from the legs on transpharyngeal resistance (Rph), minute volume of ventilation (Vmin), and partial pressure of carbon dioxide (PCO2) in men with heart failure (HF) and either obstructive (OSA) or central sleep apnea (..
  31. ncbi Acute changes in circulating concentrations of progesterone and nitric oxide and partial pressure of oxygen during prostaglandin F2alpha-induced luteolysis in cattle
    Tomas Javier Acosta
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    J Reprod Dev 55:149-55. 2009
    ..circulating concentrations of progesterone (P4) and nitrite/nitrate (the stable metabolites of NO) and the partial pressure of oxygen (pO(2)) during prostaglandin F(2alpha) (PGF(2alpha))-induced luteolysis in cattle...
  32. ncbi Effects of syringe type and storage temperature on results of blood gas analysis in arterial blood of horses
    Valerie Picandet
    Department of Clinical Sciences, Faculty of Veterinary Medicine, Universite de Montreal, Saint Hyacinthe, QC, Canada
    J Vet Intern Med 21:476-81. 2007
    ..However, the acceptable delay between time of collection and analysis for equine arterial blood gas remains unknown...
  33. pmc Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue
    Sava Sakadzic
    Photon Migration Imaging Laboratory, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    Nat Methods 7:755-9. 2010
    Measurements of oxygen partial pressure (pO(2)) with high temporal and spatial resolution in three dimensions is crucial for understanding oxygen delivery and consumption in normal and diseased brain...
  34. ncbi Variation of venous admixture, SF6 shunt, PaO2, and the PaO2/FIO2 ratio with FIO2
    J P Whiteley
    Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Br J Anaesth 88:771-8. 2002
    ..Measures of impairment of oxygenation can be affected by the inspired oxygen fraction...
  35. pmc In vivo mitochondrial oxygen tension measured by a delayed fluorescence lifetime technique
    Egbert G Mik
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Biophys J 95:3977-90. 2008
    ..The reported technology is scalable from microscopic to macroscopic applications, and its reliance on an endogenous compound greatly enhances its potential field of applications...
  36. ncbi Low pO2 and beta-estradiol induce VEGF in MCF-7 and MCF-7-5C cells: relationship to in vivo hypoxia
    A Maity
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Breast Cancer Res Treat 67:51-60. 2001
    ..Therefore, although these two cell lines grown as tumors have substantial differences in the presence and patterns of hypoxia, this could not be explained by a difference in VEGF induction...
  37. pmc Experimental and theoretical studies of oxygen gradients in rat pial microvessels
    Maithili Sharan
    Centre for Atmospheric Sciences, Indian Institute of Technology, Delhi, India
    J Cereb Blood Flow Metab 28:1597-604. 2008
    ....
  38. ncbi An evaluation of capnography monitoring during the apnoea test in brain-dead patients
    B Vivien
    Universite Pierre et Marie Curie Paris VI, Assistance Publique Hopitaux de Paris, Centre Hospitalo Universitaire Pitie Salpetriere, Department of Anesthesiology and Critical Care, Paris, France
    Eur J Anaesthesiol 24:868-75. 2007
    ..the absence of spontaneous respiratory movements during the apnoea test and an arterial carbon dioxide partial pressure above 60 mmHg...
  39. ncbi Dual responses of tissue partial pressure of oxygen after functional stimulation in rat somatosensory cortex
    Kazuto Masamoto
    School of Fundamental Science and Technology, Graduate School of Keio University, 223 8522, Yokohama, Japan
    Brain Res 979:104-13. 2003
    To compare the spatial heterogeneity of brain tissue partial pressure of oxygen (pO(2)) among local brain regions, we focused on functional and anatomical variations in rat somatosensory cortex...
  40. ncbi Postoperative hypoxemia exacerbates potential brain injury after deep hypothermic circulatory arrest
    Steven S L Tsui
    Duke University Medical Center, Division of Thoracic Surgery, Durham, North Carolina, USA
    Ann Thorac Surg 78:188-96; discussion 188-96. 2004
    ..This study reports the cerebral metabolic consequences if hypoxemic conditions are present after DHCA...
  41. pmc Photosynthetic water oxidation at elevated dioxygen partial pressure monitored by time-resolved X-ray absorption measurements
    Michael Haumann
    Freie Universitat Berlin, Institut fur Experimentalphysik, Arnimallee 14, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 105:17384-9. 2008
    ..To investigate product inhibition at elevated oxygen partial pressure (pO(2) ranging from 0...
  42. ncbi PO2 measurements in the microcirculation using phosphorescence quenching microscopy at high magnification
    Aleksander S Golub
    Department of Physiology and Biophysics, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Physiol Heart Circ Physiol 294:H2905-16. 2008
    ..Thus the SEA technique significantly improves the accuracy of microscopic Po2 measurements in the microcirculation using the PQM...
  43. ncbi High sensitivity of Lobelia dortmanna to sediment oxygen depletion following organic enrichment
    Claus Lindskov Møller
    Freshwater Biological Laboratory, Biological Institute, University of Copenhagen, Hillerød, Denmark
    New Phytol 190:320-31. 2011
    ..Brief anoxia in sediments and leaf lacunae late at night is a recurring summer phenomenon in Lobelia populations, but increased input of organic matter prolongs anoxia and reduces survival...
  44. ncbi Predicting the effect of temporal variations in PO2 on tumor radiosensitivity
    J P Kirkpatrick
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 59:822-33. 2004
    ..This article explores the effect of these temporal variations in PO(2) on the oxygen enhancement ratio, effective radiation dose to the tumor, and tumor control probability...
  45. pmc Oxygen advection and diffusion in a three- dimensional vascular anatomical network
    Qianqian Fang
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Opt Express 16:17530-41. 2008
    ..We validated this algorithm for both static and dynamic conditions. We also applied it to a complex vascular network obtained from a rodent somatosensory cortex. Qualitative agreement was found with in-vivo experiments...
  46. ncbi Automated detection of gastric luminal partial pressure of carbon dioxide during cardiovascular surgery using the Tonocap
    E Bennett-Guerrero
    Department of Anesthesiology, The Mount Sinai School of Medicine, New York, New York, USA
    Anesthesiology 92:38-45. 2000
    ..system of air tonometry (Tonocap; Datex Ohmeda, Helsinki, Finland) allows for frequent (every 15 min) measurement of gastric luminal partial pressure of carbon dioxide. Its use has not been described in cardiac surgical patients.
  47. ncbi Use of end-tidal partial pressure of carbon dioxide to predict arterial partial pressure of carbon dioxide in harp seals during isoflurane-induced anesthesia
    Daniel S J Pang
    Departement de Sciences Cliniques, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, QC, Canada
    Am J Vet Res 67:1131-5. 2006
    To evaluate the relationship between end-tidal partial pressure of CO(2) (ETCO(2)) and PaCO(2) in isoflurane-anesthetized harp seals.
  48. ncbi Role of determination of partial pressure of ammonia in cirrhotic patients with and without hepatic encephalopathy
    Francesca Nicolao
    Divisione di Gastroenterologia, Dipartimento di Medicina Clinica, Universita degli Studi di Roma La Sapienza, Viale dell Universita 37, 00185 Rome, Italy
    J Hepatol 38:441-6. 2003
    To compare venous, arterial and partial pressure of ammonia (pNH(3)) in 27 consecutive cirrhotics with hepatic encephalopathy, 15 cirrhotics without hepatic encephalopathy and nine controls; to reevaluate all parameters after the ..
  49. pmc Electron paramagnetic resonance oxygen image hypoxic fraction plus radiation dose strongly correlates with tumor cure in FSa fibrosarcomas
    Martyna Elas
    Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Int J Radiat Oncol Biol Phys 71:542-9. 2008
    ..In this study, electron paramagnetic resonance (EPR) oxygen imaging was investigated for its power to predict the success of tumor control according to tumor oxygenation level and radiation dose...
  50. ncbi Vascular endothelial growth factor gene expression in the human breast cancer cell line MX-1 is controlled by O2 availability in vitro and in vivo
    J H Marxsen
    Department of Medicine I, , Germany
    Ann Anat 183:243-9. 2001
    ..Thus, pO2-dependence of VEGF gene expression can be maintained in cancer cells, even in vivo, which may be relevant in regard to therapeutic attempts to inhibit tumor angiogenesis by increasing tumor oxygenation...
  51. ncbi The partial pressure of oxygen affects biomarkers of oxidative stress in cultured rainbow trout (Oncorhynchus mykiss) hepatocytes
    E F Finne
    Norwegian Institute for Water Research, Gaustadalleen 21, Oslo, Norway
    Toxicol In Vitro 22:1657-61. 2008
    ..The objective of the current study was to determine the extent to which differences in oxygen partial pressure would affect biomarkers of oxidative stress in a primary culture of hepatocytes from rainbow trout (..
  52. ncbi Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing
    L Isabel Cardenas-Navia
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 64:6010-7. 2004
    The primary purpose of this study was to examine the kinetics of partial pressure of oxygen (pO2) fluctuations in fibrosarcoma (FSA) and 9L tumors under air and O2 breathing conditions...
  53. ncbi Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma
    M Nordsmark
    Department of Experimental Clinical Oncology, Danish Cancer Society, Aarhus University Hospital, Aarhus, Denmark
    Int J Radiat Oncol Biol Phys 49:581-6. 2001
    ..This study was designed to compare tumor hypoxia assessed by invasive O2 sensitive electrodes and pimonidazole labeling in primary human cervix carcinomas...
  54. ncbi Exhaled breath condensate pH standardised for CO2 partial pressure
    T Kullmann
    Dept of Pathophysiology, National Korányi Institute for Tuberculosis and Pulmonology, Budapest, Hungary
    Eur Respir J 29:496-501. 2007
    ..The aim of the present study was to determine the effect of condensate CO2 partial pressure on pH and to provide a more precise mode of EBC pH determination...
  55. ncbi Noninvasive oxygen partial pressure measurement of human body fluids in vivo using magnetic resonance imaging
    Greg Zaharchuk
    University of California, San Francisco, 505 Parnassus Avenue, San Francisco, California 94143 0628, USA
    Acad Radiol 13:1016-24. 2006
    The oxygen partial pressure (pO2) of human body fluids reflects the oxygenation status of surrounding tissues. All existing fluid pO2 measurements are invasive, requiring either microelectrode/optode placement or fluid removal...
  56. ncbi Partial pressure of ammonia versus ammonia in hepatic encephalopathy
    L Kramer
    University Hospital Vienna, Department of Medicine IV, Vienna, Austria
    Hepatology 31:30-4. 2000
    ..is present in gaseous form readily enters the brain, the correlation with the grade of HE of the pH-dependent partial pressure of gaseous ammonia (pNH(3)) could be better than that of total arterial ammonia levels...
  57. ncbi Biphasic changes in tissue partial pressure of oxygen closely related to localized neural activity in guinea pig auditory cortex
    Kazuto Masamoto
    School of Fundamental Science and Technology, Graduate School of Keio University, Yokohama, Japan
    J Cereb Blood Flow Metab 23:1075-84. 2003
    ..However, spatiotemporal relations between changes in tissue partial pressure of oxygen (Po2) and induced neural activity remain incompletely understood...
  58. ncbi Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in rats
    B M Ances
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurosci Lett 306:106-10. 2001
    The partial pressure of tissue oxygen (pO2) was measured in rat somatosensory cortex during periodic electrical forepaw stimulation of either 1 min or 4 s in duration, and correlated with simultaneous laser Doppler flowmetry...
  59. ncbi Measurements of regional alveolar oxygen pressure using hyperpolarized 3He MRI
    Martin C Fischer
    Department of Radiology, University of Pennsylvania School of Medicine, B1, Stellar Chance Labs, Philadelphia, PA19104 6100, USA
    Acad Radiol 12:1430-9. 2005
    ..HP) helium-3 (3He) magnetic resonance imaging (MRI) methods to measure regional alveolar oxygen partial pressure (P(A)O2) and oxygen depletion rate (R) in the lung...
  60. ncbi Beta-adrenergic receptor stimulation and adenoviral overexpression of superoxide dismutase prevent the hypoxia-mediated decrease in Na,K-ATPase and alveolar fluid reabsorption
    Juan Litvan
    Division of Pulmonary and Critical Care Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 281:19892-8. 2006
    ..Hypoxic Adnull rats had decreased rates of AFR (0.12 +/- 0.1 ml/h) as compared with hypoxic AdSOD2 and normoxic control rats (0.47 +/- 0.04 ml/h and 0.49 +/- 0.02 ml/h, respectively), with parallel changes in Na,K-ATPase...
  61. ncbi Interhospital transportation of patients with severe lung failure on pumpless extracorporeal lung assist
    M Zimmermann
    Department of Anesthesiology, University of Regensburg, Germany
    Br J Anaesth 96:63-6. 2006
    ..To describe the use of pumpless extracorporeal interventional lung assist (iLA) for transportation of patients with severe life-threatening acute lung failure from tertiary hospitals to a specialized centre...
  62. ncbi Recovery of radial PO(2) profiles from phosphorescence quenching measurements in microvessels
    Aleksander S Golub
    Department of Physiology, Medical College of Virginia Campus, P O Box 980551, Virginia Commonwealth University, Richmond, Virginia 23298 0551, USA
    Comp Biochem Physiol A Mol Integr Physiol 132:169-76. 2002
    ..The intravascular PO(2) in these microvessels was very heterogeneous, which could be explained by the existence of significant radial PO(2) gradients. The radial PO(2) gradients were estimated to be approximately 1 mmHg/microm...
  63. ncbi Two-dimensional and three-dimensional oxygen mapping by 3He-MRI validation in a lung phantom
    Klaus Kurt Gast
    Department of Radiology, Johannes Gutenberg University Hospital, Langenbeckstrasse 1, 55131, Mainz, Germany
    Eur Radiol 15:1915-22. 2005
    ..3He-MRI in noninvasive determination of the regional, two- and three-dimensional distribution of oxygen partial pressure. In a gas-filled elastic silicon ventilation bag used as a lung phantom, oxygen sensitive two- and three-..
  64. ncbi Crater landscape: two-dimensional oxygen gradients in the circulatory system of the microcrustacean Daphnia magna
    R Pirow
    Institut fur Zoophysiologie, Westfalische Wilhelms Universitat, Hindenburgplatz 55, 48143 Münster, Germany
    J Exp Biol 207:4393-405. 2004
    ..Oxyphor R2 was injected into the circulatory system and the distribution of oxygen partial pressure (P(O(2))) in the haemolymph was measured by phosphorescence lifetime imaging in the P(O(2)) range 0-6 kPa (0-..
  65. ncbi Effects of hemorrhage on gastrointestinal oxygenation
    A Dubin
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, calle 42 No 577, 1900 La Plata, Argentina
    Intensive Care Med 27:1931-6. 2001
    ..1) To demonstrate that metabolic parameters are better indicators of tissue hypoxia than regional and whole oxygen consumption (VO(2)). (2) To compare intramucosal pH (pHi) in different gastrointestinal segments...
  66. ncbi Monitoring of end-tidal carbon dioxide partial pressure changes during infrarenal aortic cross-clamping: a non-invasive method to predict unclamping hypotension
    G Boccara
    Department of Anesthesiology and Intensive Care, DAR B, Medical University of Montpellier, France
    Acta Anaesthesiol Scand 45:188-93. 2001
    ..To assess the variations in end-tidal CO2 in response to aortic cross-clamping and the relationship with systolic arterial pressure (SAP) changes induced by unclamping...
  67. ncbi Small intestine intramucosal PCO(2) and microvascular blood flow during hypoxic and ischemic hypoxia
    Remi Neviere
    Service de Réanimation Médicale et de Médecine Hyperbare, Hopital Calmette, Lille, France
    Crit Care Med 30:379-84. 2002
    ..To determine whether small intestine intramucosal PCO(2) and mucosal blood flow changes would be different between ischemic and hypoxic hypoxia...
  68. ncbi Differential haemoglobin gene expression in the crustacean Daphnia magna exposed to different oxygen partial pressures
    Bettina Zeis
    Institut fur Zoophysiologie, Westfalische Wilhelms Universitat Munster, D 48143 Munster, Germany
    Biol Chem 384:1133-45. 2003
    The quantity and quality of the haemoglobin (Hb) of Daphnia magna is related to oxygen partial pressure in the water...
  69. ncbi Carbon dioxide pressure-concentration relationship in arterial and mixed venous blood during exercise
    X G Sun
    Division of Respiratory and Critical Care Physiology and Medicine, Harbor-University of California Los Angeles Medical Center, Torrance 90509-2910, USA
    J Appl Physiol 90:1798-810. 2001
    ..4 to 15.2 mM. We conclude that changes in buffer base and pH dominate the PCO(2)-CCO(2) relationship during exercise, with changes in Hb and blood oxyhemoglobin saturation exerting much less influence...
  70. ncbi Indispensability of the Escherichia coli carbonic anhydrases YadF and CynT in cell proliferation at a low CO2 partial pressure
    Masayuki Hashimoto
    Department of Biology, Tokyo Metropolitan University, Minamiohsawa, Hachioji, Tokyo 192 0397, Japan
    Biosci Biotechnol Biochem 67:919-22. 2003
    ..This suggests that these carbonic anhydrases are essential because they maintain HCO3- levels at ambient CO2 concentrations...
  71. pmc Effects of carbonic anhydrase inhibition on ventilation-perfusion matching in the dog lung
    E R Swenson
    Department of Medicine, University of Washington, Seattle 98195
    J Clin Invest 92:702-9. 1993
    ..These results support the concept that lung CA subserves VA/Q matching in the normal lung...
  72. ncbi Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock
    T J VanderMeer
    Department of Surgery, Beth Israel Hospital, Boston, MA 02215, USA
    Crit Care Med 23:1217-26. 1995
    ..To evaluate the hypothesis that splanchnic ischemia and mucosal hypoxia are responsible for lipopolysaccharide-induced intramucosal acidosis in pigs...
  73. ncbi Human pulmonary vascular response to 4 h of hypercapnia and hypocapnia measured using Doppler echocardiography
    George M Balanos
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Appl Physiol 94:1543-51. 2003
    ..The human pulmonary circulatory response to changes in Pco(2) has a slower time course and greater sensitivity than is commonly assumed. Vascular tone in the normal pulmonary circulation is substantial...
  74. ncbi Magnitude of the second gas effect on arterial sevoflurane partial pressure
    Philip J Peyton
    Department of Anaesthesia, Austin Hospital, Heidelberg, Melbourne, Australia
    Anesthesiology 108:381-7. 2008
    A number of studies have demonstrated a faster rate of increase in end-expired partial pressure as a fraction of inspired (Pa/Pi) for volatile agents in the presence of high concentrations of nitrous oxide, consistent with the second gas ..
  75. pmc Esophageal capnometry during hemorrhagic shock and after resuscitation in rats
    Balagangadhar R Totapally
    Associate Professor and Research Director, Division of Critical Care Medicine, Miami Children s Hospital, Miami, Florida, USA
    Crit Care 7:79-84. 2003
    ....
  76. pmc Influence of flow on mucosal-to-arterial carbon dioxide difference
    Benoit Vallet
    Department of Anesthesiology and Intensive Care Medicine, University Hospital of Lille, Lille, France
    Crit Care 6:463-4. 2002
  77. pmc Intramucosal-arterial PCO2 gap fails to reflect intestinal dysoxia in hypoxic hypoxia
    Arnaldo Dubin
    Catedra de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Argentina
    Crit Care 6:514-20. 2002
    ..An elevation in intramucosal-arterial PCO2 gradient (DeltaPCO2) could be determined either by tissue hypoxia or by reduced blood flow. Our hypothesis was that in hypoxic hypoxia with preserved blood flow, DeltaPCO2 should not be altered...
  78. ncbi Comparison of brain tissue and local cerebral venous gas tensions and pH
    G J Edelman
    Department of Anesthesiology, University of Illinois at Chicago, IL, USA
    Neurol Res 22:642-4. 2000
    ..Tissue sensors such as the Neurotrend probe can offer reliable trend indications in brain tissue gas tensions and pH...
  79. pmc Partial pressure of end-tidal carbon dioxide successful predicts cardiopulmonary resuscitation in the field: a prospective observational study
    Miran Kolar
    Medikmiko General Practice, Gregorciceva, 3000 Celje, Slovenia
    Crit Care 12:R115. 2008
    ....
  80. ncbi Storage of strain-specific rat blood limits cerebral tissue oxygen delivery during acute fluid resuscitation
    A Rigamonti
    Department of Anaesthesia, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    Br J Anaesth 100:357-64. 2008
    ..Some studies demonstrate reduced microvascular oxygen delivery, whereas others do not. We hypothesize that storage of rat blood will limit its ability to deliver oxygen to cerebral tissue...
  81. ncbi A simple solution is "prime" for fetal cardiopulmonary bypass
    R Scott Baker
    Division of Cardiothoracic Surgery, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    ASAIO J 53:710-5. 2007
    ..Calcium addition to the prime adversely affects fetal gas exchange worsening acidosis during fetal bypass. Bicarbonate addition to the prime is also detrimental to the fetus resulting in greater CO2 production and impaired hemodynamics...
  82. ncbi The effect of O2 and CO2 on the dive behavior and heart rate of lesser scaup ducks (Aythya affinis): quantification of the critical PaO2 that initiates a diving bradycardia
    Kim A Borg
    Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, BC, V6T 1Z4, Canada
    Respir Physiol Neurobiol 144:263-79. 2004
    ....
  83. ncbi Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats
    Stephen R Reeves
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, Suite 204, 570 South Preston St, Louisville, KY 40202, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1664-71. 2006
    ..e., metaplasticity) and markedly differ from previously reported increased neural plasticity changes induced by CIH in adult rats...
  84. ncbi Can carotid body perfusion act as a respiratory controller?
    Arho Virkki
    Biomathematics Research Group, Department of Mathematics, University of Turku, FIN 20014 Turku, Finland
    J Theor Biol 249:737-48. 2007
    ..to the arterial O(2) and CO(2) levels is assumed to be mediated via the controller's intracellular O(2) partial pressure and pH...
  85. ncbi Coronary sinus venoarterial CO2 difference in different hemodynamic states
    G Vretzakis
    University Hos of Alexandroupolis, Greece
    Acta Anaesthesiol Belg 55:221-7. 2004
    ..to examine the impact of the variations of cardiac mechanical work on veno-arterial CO2 content and partial pressure difference (deltaPCO2) of the coronary sinus blood...
  86. ncbi Experimental retinal vein occlusion: effect of acetazolamide and carbogen (95% O2/5% CO2) on preretinal PO2
    Jean Antoine C Pournaras
    Department of Ophthalmology, University Hospital of Geneva, Geneva, Switzerland
    Invest Ophthalmol Vis Sci 45:3669-77. 2004
    To evaluate the variations of preretinal oxygen partial pressure (Po(2)) in normal and in ischemic postexperimental branch retinal vein occlusion (BRVO) areas, during normoxia, hyperoxia (100% O(2)), and carbogen (95% O(2), 5% CO(2)) ..
  87. ncbi Acclimation to hypoxia does not improve hypoxic survival of the immature pig in confined atmosphere
    Ran Arieli
    Israel Naval Medical Institute, IDF Medical Corps, PO Box 8040, 31 080 Haifa, Israel
    Mil Med 173:107-11. 2008
    ..Humans may be accidentally trapped in a confined atmosphere in which oxygen availability is limited. If acclimation would extend survival, hypoxic acclimation in confined spaces would be recommended...
  88. ncbi Relationship between baseline cerebral blood flow and vascular responses to changes in PaCO2 measured by positron emission tomography in humans: implication of inter-individual variations of cerebral vascular tone
    H Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    Acta Physiol (Oxf) 193:325-30. 2008
    ..In the present study, the relationship between CBF and cerebral vascular tone to inter-individual variation at rest condition was investigated using positron emission tomography (PET)...
  89. ncbi Pulmonary gas exchange in the morbidly obese
    G S Zavorsky
    Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, Saint Louis, Missouri 63117, USA
    Obes Rev 9:326-39. 2008
    ..The alveolar-to-arterial oxygen partial pressure difference (AaDO2) was large at rest in upright subjects at sea level (23, range 5-38 mmHg) while the ..
  90. ncbi Validation and application of a high-fidelity, computational model of acute respiratory distress syndrome to the examination of the indices of oxygenation at constant lung-state
    R A McCahon
    University Department of Anaesthesia, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Br J Anaesth 101:358-65. 2008
    ..The study is the first step in developing an accurate and non-invasive tool to quantify oxygenation defects...
  91. ncbi Tacrolimus ameliorates cerebral vasodilatation and intracranial hypertension in the rat with portacaval anastomosis and hyperammonemia
    Thomas Dethloff
    Department of Hepatology, Copenhagen University Hospital, Copenhagen, Denmark
    Liver Transpl 10:922-7. 2004
    ..These findings indicate that tacrolimus could be of clinical value in the prevention of cerebral hyperemia, high ICP, and serious brain damage in patients with FHF...
  92. ncbi Seasonal changes in blood oxygen transport and acid-base status in the tegu lizard, Tupinambis merianae
    Denis V Andrade
    Departamento de Zoologia, Universidade Estadual Paulista, Caixa Postal 199, 13500 970 Rio Claro, SP, Brazil
    Respir Physiol Neurobiol 140:197-208. 2004
    ..Dormancy was accompanied by an increase in plasma bicarbonate ([HCO-(3)]pl) and an elevation of arterial CO2 partial pressure (PaCO2) and CO2 content in the plasma (CplCO2)...
  93. ncbi [Experimental branch vein occlusion: the effect of carbogen breathing on preretinal PO2]
    J A C Pournaras
    Hopitaux Universitaires de Geneve, Clinique d ophtalmologie, 22, Rue Alcide Jentzer 22, 1211 Geneve 14, Suisse
    J Fr Ophtalmol 26:813-8. 2003
    ..To evaluate the variations in preretinal PO2 in normal and in ischemic postexperimental branch vein occlusion (BRVO) retinal areas during normoxia, hyperoxia (100% O2) and carbogen (95% O2, 5% CO2) breathing...
  94. ncbi [Comparative study of six blood gas analysers]
    M F Daures
    Laboratoire de Biochimie, Hopital Saint Eloi, Montpellier
    Ann Biol Clin (Paris) 65:505-18. 2007
    ..A high level of statistic concordance was observed between the different analysers. So the equipment has been selected using biological, analytic and computing criteria...
  95. ncbi Changes in respiratory control after 5 days at altitude
    Ron B Somogyi
    Department of Physiology, University of Toronto, Medical Science Bldg, Room 3326, 1 Kings College Circle, Toronto, Ont, Canada, M5S 1A8
    Respir Physiol Neurobiol 145:41-52. 2005
    ..6+/-0.30 g L(-1) to 49.8+/-0.76 g L(-1). We suggest that the respiratory alkalosis was produced by a fall in the chemoreflex threshold and pH was corrected by an elevation in the concentration of weakly dissociated protein anions...
  96. ncbi Increased expired NO and roles of CO2 and endogenous NO after venous gas embolism in rabbits
    Per Agvald
    Department of Physiology and Pharmacology, Karolinska Institutet, 17177, Stockholm, Sweden
    Eur J Appl Physiol 97:210-5. 2006
    ..Furthermore, an intact NO production may be critical for the tolerance to VGE. Finally, FeNO might have a potential in the diagnosis and monitoring of pulmonary gas embolism...
  97. pmc Tissue oxygenation response to mild hypercapnia during cardiopulmonary bypass with constant pump output
    O Akca
    Outcomes Research Institute, University of Louisville, KY 40202, USA
    Br J Anaesth 96:708-14. 2006
    ..However, relative contributions of increased cardiac output and peripheral vasodilation to this response remains unknown. We thus tested the hypothesis that increased cardiac output is the dominant mechanism...
  98. ncbi Effect of carbogen breathing and acetazolamide on optic disc PO2
    Ioannis K Petropoulos
    Department of Ophthalmology, University Hospitals of Geneva, Switzerland
    Invest Ophthalmol Vis Sci 46:4139-46. 2005
    Acetazolamide was previously shown to increase optic disc partial pressure of oxygen (PO(2))...
  99. ncbi Acute physiologic predictors of mortality and functional and cognitive recovery in hemorrhagic stroke: 1-, 3-, and 6-month assessments
    WhaSook Seo
    Department of Nursing, College of Medicine, Inha University, Incheon, Republic of Korea
    J Stroke Cerebrovasc Dis 16:57-63. 2007
    ..It appears that the physiologic predictors of hemorrhagic stroke are remarkably dependent on outcome definitions (i.e., mortality, functional disability, or cognitive ability), but not with recovery times...
  100. ncbi Zacopride and 8-OH-DPAT reverse opioid-induced respiratory depression and hypoxia but not catatonic immobilization in goats
    Leith C R Meyer
    Brain Function Research Unit, School of Physiology, University of the Witwatersrand, South Africa
    Am J Physiol Regul Integr Comp Physiol 290:R405-13. 2006
    ..013), percent hemoglobin oxygen saturation (P < 0.0001), and arterial oxygen partial pressure [Pa(O2); F(10,70) = 5.67, P < 0.05] and increased arterial carbon dioxide partial pressure [F(10,70) = 3...
  101. ncbi [Gasometric alterations in hospitalized cirrhotic patients]
    V Lorenzo-Zúñiga
    Servicio de Aparato Digestivo, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona
    An Med Interna 22:209-12. 2005
    ..The aim of this study was to describe the frequency and severity of gasometric alterations in hospitalized cirrhotic patients, a their correlation with hepatocellular disfunction...

Research Grants62

  1. Human Pluripotent Stem Cell Differentiation with Defined O2 & Protein Engagement
    ROBERT SAMUEL LANGER; Fiscal Year: 2010
    ..incorporating defined extracellular matrix (ECM) components that allow for accurate control of oxygen partial pressure of the cell surface (pO2cell) to provide more physiological conditions and allow strategies to better mimic ..
  2. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    David Stump; Fiscal Year: 2013
    ..air emboli can be prevented during open heart surgery by flooding the operative field with argon, a low partial pressure gas...
  3. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    William Brown; Fiscal Year: 2009
    ..air emboli can be prevented during open heart surgery by flooding the operative field with argon, a low partial pressure gas...
  4. Ocular Oxygen Metabolism and the Etiology of Open Angle Glaucoma
    Carla J Siegfried; Fiscal Year: 2013
    ..Our hypothesis is based on measurements of oxygen partial pressure (pO2), made in the human eye during surgery using a thin, flexible, fiberoptic probe...
  5. Imaging regional physiologic parameters of lung function
    Rahim R Rizi; Fiscal Year: 2011
    ..the first funding cycle we designed and implemented various methods to accurately measure regional alveolar partial pressure of oxygen, ventilation, perfusion, and ventilation-to-perfusion ratio, as well as oxygen depletion rate and ..
  6. Reliable Evaluation of Coronary Artery Disease using Myocardial BOLD MRI with CO2
    Rohan Dharmakumar; Fiscal Year: 2013
    ..The proposed method utilizes (i) an individualized targeted change in arterial partial pressure of CO2 (PaCO2) as the non-invasive vasoactive stimulus, (ii) fast, high-resolution, 4D BOLD MRI at 3T and (..
  7. Neurological and cognitive effects of hyperoxia after cardiac arrest
    STEPHEN WALTER TRZECIAK; Fiscal Year: 2013
    ..Recent data suggest that exposure to hyperoxia (i.e. supranormal arterial oxygen partial pressure due to an excessively high fraction of inspired oxygen [FiO2]) after ROSC may accelerate oxidative stress, ..
  8. Non-invasive neonatal respiration monitor
    ROSE MARIE VISCARDI; Fiscal Year: 2013
    ..Specific problems of this kind are extremes in arterial partial pressure of oxygen and carbon dioxide...
  9. Role of Carotid Bodies in Glucose Regulation and Counter Regulation in Humans
    Michael J Joyner; Fiscal Year: 2013
    ..cells and animal models indicate these receptors also sense changes in blood glucose and that changes in the partial pressure of oxygen (pO2) alter this sensitivity...
  10. Circulatory system and integrated muscle tissue for drug and tissue toxicity
    George A Truskey; Fiscal Year: 2013
    ..Different levels of oxygen partial pressure in the arterial and venous inflow lines will be used to produce a range of oxygen gradients...
  11. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    CINDY ANNE MORRIS; Fiscal Year: 2012
    ..in other systems, is capable of activating herpesvirus gene expression and lytic replication, low oxygen partial pressure during placentation may actually augment the ability of HCMV to inhibit EVT invasion...
  12. In Vivo Imaging Alzheimers Disease Pathology with 2-Photon/Lifetime Microscopy
    MOHAMMAD ABBAS YASEEN; Fiscal Year: 2013
    ..Through the use of novel dendritic Pd-porphyrin phosphors, cerebral oxygen partial pressure (pO2) in brain tissue and vasculature can also be measured with high resolution using two-photon microscopy...
  13. Luminescent Oxygen Nanosensors for Tumor Hypoxia Imaging
    Cassandra L Fraser; Fiscal Year: 2013
    ..Despite the importance of oxygen partial pressure (pO2) to biomedicine, its assessment is often limited to oxygen consumption rate (OCR) measurements, invasive ..
  14. Age Dependent Mechanical Ventilator-Induced Inflammation: Modeling &Experiments
    ANGELA MARIE REYNOLDS; Fiscal Year: 2013
    ..We will use a model of gas exchange (partial differential equations) to quantify changes in the partial pressure of oxygen and carbon dioxide in circulating blood due to mechanical ventilator-induced inflammation...
  15. Quantitative Structural and Functional Imaging of the Lung
    Rahim R Rizi; Fiscal Year: 2013
    ..We recently implemented a novel method for measuring the regional partial pressure of oxygen and furthered the development of a method for evaluating emphysema using the measurement of the ..
  16. Intracellular oxygen sensing using 19F MRI
    Eric T Ahrens; Fiscal Year: 2013
    ..to PFC results in a reduction in the 19F spin-lattice relaxation time (T1), where T1 varies linearly with the partial pressure of oxygen (pO2)...
  17. Contribution of ASIC channels to intrinsic chemosensitivity of NTS neurons
    Rafiq Huda; Fiscal Year: 2013
    ..serves an indispensable biological function and determines essential physiological parameters such as pH and partial pressure of carbon dioxide (PCO2)...
  18. Phase II, randomized controlled trial of brain tissue oxygen monitoring
    Nancy R Temkin; Fiscal Year: 2011
    ..Recently, it has become feasible to directly and continuously monitor the partial pressure of oxygen in brain tissue (pBrO2)...
  19. Real-time Monitoring of cerebral tissue oxygen in ischemic stroke
    Nadeem Khan; Fiscal Year: 2013
    ..therapies, it is crucial to understand the effect of ischemic stroke on cerebral tissue oxygen (pO2, partial pressure of oxygen) in the ischemic as well as contralateral regions of a clinically pertinent model of stroke...
  20. Adaptable Hydrogel Oxygen Delivery Platform for Wound Care
    Nic Leipzig; Fiscal Year: 2013
    ..often show devastatingly low oxygen concentrations, as low as 5 mmHg oxygen partial pressure (PO2 )...
  21. Brain Chemistry and Altitude in Bipolar Disorder
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..One such environmental factor may be altitude. Extreme altitudes are associated with a decreased partial pressure of inspired oxygen, and this hypobaric hypoxia results in significant cognitive impairment...
  22. Sparse multispectral processing for accelerated EPR oximetry in three dimensions
    Lee C Potter; Fiscal Year: 2010
    ..EPR can be used to measure the partial pressure of oxygen by observing oxygen-induced broadening in the lineshape of an introduced paramagnetic probe...
  23. Dark adaptation and hypoxia in diabetic retinopathy
    Eric A Newman; Fiscal Year: 2013
    ..Key predictions of this hypothesis remain untested. Notably, retinal pO2 (oxygen partial pressure) has never been directly measured during early stages of diabetic retinopathy...
  24. Host-microbial interactions in the gut oxygen equilibrium
    Gary D Wu; Fiscal Year: 2013
    ..water- soluble oxygen-sensitive dyes - a technical advance that has led to the following two observations: 1) Partial pressure of oxygen (pO2) in the cecal lumen is remarkably lower than pO2 in the adjacent tissue;2) Inspiration of pure ..
  25. High resolution functional MRI of columnar structures
    Ravi Menon; Fiscal Year: 2007
    ..The partial pressure of oxygen in the tissue (pO2) will be measured using a commercial fluorescence-lifetime fiber optic technique ..
  26. An implantable sensor for wireless measurement of interstitial pressure
    Babak Ziaie; Fiscal Year: 2013
    ..addition to chemotherapy, radiation therapy can also benefit from lowering the IFP by increasing the oxygen partial pressure in hypoxic tumor regions...
  27. Imaging Regional Physiological and Structural Parameters of Airway Remodeling
    Kiarash Emami; Fiscal Year: 2009
    ..hyperpolarized gas magnetic resonance imaging techniques to measure regional pulmonary ventilation (VA), partial pressure of oxygen (PAO2) and helium-3 apparent diffusion of coefficient (ADC) in the lungs of healthy mice, as well ..
  28. Development of Hyperpolarized Helium for Assessing ILD
    Milton Rossman; Fiscal Year: 2009
    ..to measure three important parameters in pulmonary fibrosis: alveolar size, compliance, and the alveolar partial pressure of oxygen...
  29. TOXICOLOGY OF COMBUSTION GENERATED ACID AEROSOLS
    MARY AMDUR; Fiscal Year: 1991
    ..impregnated with Fe or Cu are burned in a laminar-flow furnace permitting control of temperature and 02 partial pressure. Special emphasis is placed on determination of H2S04, both as free H2S04 and as a layer on ultrafine ..
  30. Cardio-Respiratory Interaction: Contribution in Syncope
    Abhijit Patwardhan; Fiscal Year: 2003
    ..We hypothesize the following chain of events: transient disturbances in arterial partial pressure of carbon dioxide (PCO2), precipitated by oscillations in perfusion, trigger ventilatory adjustments...
  31. SUBCUTANEOUS GLUCOSE BIOSENSORS
    Adam Heller; Fiscal Year: 1999
    ..29mm OD) flexible glucose sensors that have no leachable components; are insensitive to variation of partial pressure of oxygen; are insensitive to interferants; operate at 37degreesC for one week with only 4% variation in ..
  32. Modeling Brain Hypoxia to Predict Clinical Outcomes
    Eugene Bruce; Fiscal Year: 2006
    ..hyperbaric (HBO) hyperoxia, treatments that are presumed to increase partial pressure of oxygen (PO2) in brain tissue and minimize injury...
  33. MINIATURIZED LACTATE SENSOR--CRITICAL CARE APPLICATION
    HERBERT SILVERMAN; Fiscal Year: 1993
    ..advantages in accuracy, sensitivity, speed, no leachable components, insensitivity to variation in oxygen partial pressure, insensitivity to interferants, miniaturization (high signal level and small sample size), high stability, ..
  34. Aging, Chronic Disease and Skeletal Muscle Perfusion
    Timothy Musch; Fiscal Year: 2002
    ..microspheres, intravital microscopy) and novel (phosphorescence quenching measurement of micro vascular partial pressure of O2 (PO2)) methodologies to explore the effects of aging and chronic disease on muscle structure, blood ..
  35. O2 GENERATORS FOR EMERGENCY VENTILATORY SUPPORT DEVICES
    ARNOLD GORDON; Fiscal Year: 1993
    ..It will do so using either wall current or a rechargeable battery pack. The total pressure, oxygen partial pressure and the overall flow rate that is generated will be adjustable.
  36. Retinal Image Quality in Retinal-diseased Eyes
    Mahnaz Shahidi; Fiscal Year: 2010
    ....
  37. MR STUDIES OF EXPERIMENTAL RETINOPATHY OF PREMATURITY
    BRUCE BERKOWITZ; Fiscal Year: 2001
    ..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
  38. MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFER
    David Poole; Fiscal Year: 2001
    ....
  39. Noninvsive Imaging of Chorio-retinal Oxygen Tension
    Mahnaz Shahidi; Fiscal Year: 2005
    ..abstract_text> ..
  40. Predicting Radiation Response by Tumor pO2
    Cameron Koch; Fiscal Year: 2006
    ..DDFP may thus be the first PFC emulsion practical and safe for use in multifraction clinical regimens. ..
  41. Oxidative Damage to DNA Repair Pathways
    Cameron Koch; Fiscal Year: 2006
    ..Specific Aim 3 will investigate other aspects of DNA repair and DNA structural organization to determine their sensitivity to redox regulation. ..
  42. 13th International Congress of Radiation Research
    Mark Dewhirst; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  43. Spectral-Encoding for Video-Rate Hemodynamic Tomography
    Brian Pogue; Fiscal Year: 2007
    ..abstract_text> ..
  44. Manganese-enhanced MRI Studies of Retinal Neovascularization
    BRUCE BERKOWITZ; Fiscal Year: 2008
    ..The novel methods in this application will also contribute to the advancement of functional MRI for the study of retinal diseases. [unreadable] [unreadable] [unreadable]..
  45. PET Imaging of Hypoxia with EF5
    Cameron Koch; Fiscal Year: 2009
    ..In summary, the aims of this grant will extend and advance our overall laboratory interest in quantifying the degree and extent of clinically relevant hypoxia in the tumor microenvironment. ..
  46. Retinal Oxygenation in Diabetic Retinopathy
    BRUCE BERKOWITZ; Fiscal Year: 2004
    ..We have developed a unique functional magnetic resonance imaging (fMRI) technique that measures the change in partial pressure of oxygen (deltaPO2) in the vitreous humor while the subject breathes carbogen (95% O2: 5% CO2)...
  47. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2008
    ..abstract_text> ..
  48. Evaluation of Hypoxia by EF5 Binding in Cervix Cancer
    Sydney Evans; Fiscal Year: 2003
    ..This will allow conversion of binding to tumor pO2. Further analyses will incorporate the area of tissue involved at various binding levels. Patient follow-up and statistical evaluations will be provided by the GOG. ..
  49. Deposition of 0.5 to 2 Micron Aerosol in the Human Lung
    G Prisk; Fiscal Year: 2003
    ..5 to 1 micron). Such information will provide a much-improved basis for the assessment of exposure to small inhaled particles both in long duration spaceflight and on Earth. ..
  50. CO POISONING IN THE CONTEXT OF A REPERFUSION INJURY
    Stephen Thom; Fiscal Year: 2003
    ..The research plan is aimed to test the hypothesis that immune responses and the associated oxidative stress cause neurological injuries. ..
  51. Near infrared/MR system for imaging brain oxygenation
    Jeffrey Dunn; Fiscal Year: 2002
    ..This grant will produce a novel imaging modality which can non-invasively monitor cerebral oxygenation, structure, and blood flow. ..
  52. DOPAMINE AND PLASTICITY IN RESPIRATORY CONTROL
    Rebecca Johnson; Fiscal Year: 2002
    ..End of Abstract) ..
  53. In vivo studies of cerebral angiogenesis and oxygenation
    Jeffrey Dunn; Fiscal Year: 2008
    ....
  54. Assessment of Hypoxia in Malignant Gliomas Using EF5
    Sydney Evans; Fiscal Year: 2002
    ..We project that we will be able to institute clinical EF5 PET studies at PENN in patients with brain tumors in approximately 2 years, corresponding to the time that much of the data from the studies proposed herein will mature. ..
  55. Monitoring Oxygen Repeatedly for Hypoxic Tumor Therapy
    Mohammad Khan; Fiscal Year: 2007
    ..If successful, this approach potentially could be immediately extended for clinical applications. [unreadable] [unreadable] [unreadable]..
  56. Functional measure of 3rd trimester FASD: neonatal sheep
    TIMOTHY CUDD; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  57. Microenvironment: Imaging/Implications in Brain Tumors
    Sydney Evans; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  58. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
  59. Brain O2 defense during hibernation and arousal
    Yi Ma; Fiscal Year: 2006
    ..The overall approach of these studies is to use freely moving unanesthetized adult AGS and a novel preparation to monitor in-vivo real time PtO2 in hibernating animals. [unreadable] [unreadable]..
  60. Molecular imaging using hyperpolarized carbon-13
    Stephen Kadlecek; Fiscal Year: 2007
    ..Key Words: Polarized Carbon-13 MRI; Metabolic imaging; Molecular imaging. [unreadable] [unreadable] [unreadable]..
  61. Defining Molecular Markers for Tumor Hypoxia
    QUYNH THU XUAN LE; Fiscal Year: 2010
    ..abstract_text> ..