pressure

Summary

Top Publications

  1. ncbi Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions
    Manu L N G Malbrain
    Department of Intensive Care, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, 2060, Antwerpen 6, Belgium
    Intensive Care Med 32:1722-32. 2006
  2. pmc A dual pressure linear ion trap Orbitrap instrument with very high sequencing speed
    Jesper V Olsen
    Thermo Fisher Scientific Bremen GmbH, Hanna Kunath Strasse 11, 28199 Bremen, Germany
    Mol Cell Proteomics 8:2759-69. 2009
  3. ncbi Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study
    Manu L N G Malbrain
    Intensive Care Unit Director, Medical Intensive Care Unit, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerpen 6, Belgium
    Crit Care Med 33:315-22. 2005
  4. doi Developmental patterning by mechanical signals in Arabidopsis
    Olivier Hamant
    INRA, Laboratoire de Reproduction et Développement des Plantes, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Science 322:1650-5. 2008
  5. ncbi Measurement of blast wave by a miniature fiber optic pressure transducer in the rat brain
    Mikulas Chavko
    Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910, United States
    J Neurosci Methods 159:277-81. 2007
  6. ncbi Good urodynamic practices: uroflowmetry, filling cystometry, and pressure-flow studies
    Werner Schäfer
    International Continence Society Office, Southme Hospital, Bristol, BSIO 5NB, United Kingdom
    Neurourol Urodyn 21:261-74. 2002
  7. ncbi Direct measurement of cell wall stress stiffening and turgor pressure in live bacterial cells
    Yi Deng
    Department of Physics, Princeton University, Princeton, New Jersey 08544, USA
    Phys Rev Lett 107:158101. 2011
  8. ncbi Different techniques to measure intra-abdominal pressure (IAP): time for a critical re-appraisal
    Manu L N G Malbrain
    Medical Intensive Care Unit, ACZA Campus Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerp, Belgium
    Intensive Care Med 30:357-71. 2004
  9. doi Electron microscopy of high pressure frozen samples: bridging the gap between cellular ultrastructure and atomic resolution
    Daniel Studer
    Institute for Anatomy, University of Bern, Baltzerstr 2, 3000, Bern 9, Switzerland
    Histochem Cell Biol 130:877-89. 2008
  10. ncbi New in vivo measurements of pressures in the intervertebral disc in daily life
    H J Wilke
    Abteilung für kräftigungstherapie und Rehabilitation, Schmerzklinik Kirschgarten, Basel, Switzerland
    Spine (Phila Pa 1976) 24:755-62. 1999

Research Grants

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
  3. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
  4. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
  5. Yasmin Wadia; Fiscal Year: 2014
  6. Jill M Wecht; Fiscal Year: 2014
  7. Noreen F Rossi; Fiscal Year: 2016
  8. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
  9. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
  10. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013

Detail Information

Publications434 found, 100 shown here

  1. ncbi Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions
    Manu L N G Malbrain
    Department of Intensive Care, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, 2060, Antwerpen 6, Belgium
    Intensive Care Med 32:1722-32. 2006
    ..The variety of definitions proposed has led to confusion and difficulty in comparing one study to another...
  2. pmc A dual pressure linear ion trap Orbitrap instrument with very high sequencing speed
    Jesper V Olsen
    Thermo Fisher Scientific Bremen GmbH, Hanna Kunath Strasse 11, 28199 Bremen, Germany
    Mol Cell Proteomics 8:2759-69. 2009
    ..ion guide with 10-fold higher transfer efficiency in MS/MS mode and 3-5-fold in full scan spectra, by a dual pressure ion trap configuration, and by reduction of overhead times between scans...
  3. ncbi Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study
    Manu L N G Malbrain
    Intensive Care Unit Director, Medical Intensive Care Unit, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerpen 6, Belgium
    Crit Care Med 33:315-22. 2005
    ..The aim of this study was to assess, in a mixed population of critically ill patients, whether intraabdominal pressure at admission was an independent predictor for mortality and to evaluate the effects of intraabdominal ..
  4. doi Developmental patterning by mechanical signals in Arabidopsis
    Olivier Hamant
    INRA, Laboratoire de Reproduction et Développement des Plantes, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Science 322:1650-5. 2008
    ....
  5. ncbi Measurement of blast wave by a miniature fiber optic pressure transducer in the rat brain
    Mikulas Chavko
    Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910, United States
    J Neurosci Methods 159:277-81. 2007
    ..The aim of this study was to investigate pressure changes induced by exposure to blast inside the rat brain...
  6. ncbi Good urodynamic practices: uroflowmetry, filling cystometry, and pressure-flow studies
    Werner Schäfer
    International Continence Society Office, Southme Hospital, Bristol, BSIO 5NB, United Kingdom
    Neurourol Urodyn 21:261-74. 2002
    ..This report focuses on the most common urodynamics examinations; uroflowmetry, pressure recording during filling cystometry, and combined pressure-flow studies...
  7. ncbi Direct measurement of cell wall stress stiffening and turgor pressure in live bacterial cells
    Yi Deng
    Department of Physics, Princeton University, Princeton, New Jersey 08544, USA
    Phys Rev Lett 107:158101. 2011
    ..Escherichia coli cells using atomic force microscopy to separate the contributions of the cell wall and turgor pressure to the overall cell stiffness. We find strong evidence of power-law stress stiffening in the E...
  8. ncbi Different techniques to measure intra-abdominal pressure (IAP): time for a critical re-appraisal
    Manu L N G Malbrain
    Medical Intensive Care Unit, ACZA Campus Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerp, Belgium
    Intensive Care Med 30:357-71. 2004
    ..IAH) or abdominal compartment syndrome (ACS) is heavily dependent on the reproducibility of the intra-abdominal pressure (IAP) measurement technique...
  9. doi Electron microscopy of high pressure frozen samples: bridging the gap between cellular ultrastructure and atomic resolution
    Daniel Studer
    Institute for Anatomy, University of Bern, Baltzerstr 2, 3000, Bern 9, Switzerland
    Histochem Cell Biol 130:877-89. 2008
    ..Cryofixation by high pressure freezing circumvents many of the artifacts since it allows vitrifying biological samples of about 200 mum in ..
  10. ncbi New in vivo measurements of pressures in the intervertebral disc in daily life
    H J Wilke
    Abteilung für kräftigungstherapie und Rehabilitation, Schmerzklinik Kirschgarten, Basel, Switzerland
    Spine (Phila Pa 1976) 24:755-62. 1999
    We conducted intradiscal pressure measurements with one volunteer performing various activities normally found in daily life, sports, and spinal therapy.
  11. pmc From dynamic live cell imaging to 3D ultrastructure: novel integrated methods for high pressure freezing and correlative light-electron microscopy
    Coralie Spiegelhalter
    Imaging Centre, IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France
    PLoS ONE 5:e9014. 2010
    ..In cell biology, the study of proteins and organelles requires the combination of different imaging approaches, from live recordings with light microscopy (LM) to electron microscopy (EM)...
  12. doi A human knee joint model considering fluid pressure and fiber orientation in cartilages and menisci
    K B Gu
    Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive, NW, Calgary, Alberta, Canada T2N 1N4
    Med Eng Phys 33:497-503. 2011
    ..In the present study, the fluid pressure and site-specific collagen fiber orientation in the cartilages and menisci were implemented into a finite element ..
  13. pmc The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems
    Min Wu
    Department of Mathematics, University of California, Irvine, USA
    J Theor Biol 320:131-51. 2013
    The flow of interstitial fluid and the associated interstitial fluid pressure (IFP) in solid tumors and surrounding host tissues have been identified as critical elements in cancer growth and vascularization...
  14. ncbi High-pressure freezing provides insights into Weibel-Palade body biogenesis
    Helen L Zenner
    MRC Laboratory of Molecular Cell Biology, Cell Biology Unit, and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK
    J Cell Sci 120:2117-25. 2007
    ..By using high-pressure freezing and freeze substitution before electron microscopy, we visualised VWF tubules in the trans-Golgi network ..
  15. doi Interstitial fluid pressure in tumors: therapeutic barrier and biomarker of angiogenesis
    Sarah Jane Lunt
    Division of Applied Molecular Oncology, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Future Oncol 4:793-802. 2008
    Interstitial fluid pressure is elevated in virtually all solid malignant tumors as a result of abnormalities of the vasculature and interstitium...
  16. doi Biomechanical assessment of brain dynamic responses due to blast pressure waves
    M S Chafi
    Department of Mechanical Engineering and Applied Mechanics, North Dakota State University, Fargo, ND 58105 5285, USA
    Ann Biomed Eng 38:490-504. 2010
    ..is a 3-D geometrically realistic configuration that has been previously validated against the brain intracranial pressure (ICP), as well as shear and principal strains under different impact loadings of cadaveric experimental tests of ..
  17. doi Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis
    Muhittin Tasdogan
    Department of Anaesthesiology and Reanimation, Trakya University Medical Faculty, 22030 Edirne, Turkey
    J Clin Anesth 21:394-400. 2009
    ..infusion of propofol and the alpha-2 adrenoceptor, dexmedetomidine, on inflammatory responses and intraabdominal pressure (IAP) in severe sepsis after abdominal surgery, specifically, serum cytokine levels (interleukin [IL]-1, IL-6, ..
  18. pmc A quantitative pressure and microbubble-size dependence study of focused ultrasound-induced blood-brain barrier opening reversibility in vivo using MRI
    Gesthimani Samiotaki
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Magn Reson Med 67:769-77. 2012
    ..In this study, we investigate the dependence of the BBB opening's reversibility on the peak-rarefactional pressure (0.30-0...
  19. doi Bioinspired self-repairing slippery surfaces with pressure-stable omniphobicity
    Tak Sing Wong
    School of Engineering and Applied Sciences, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 477:443-7. 2011
    ..restrict their practical applications: limited oleophobicity with high contact angle hysteresis, failure under pressure and upon physical damage, inability to self-heal and high production cost...
  20. doi Flexible polymer transistors with high pressure sensitivity for application in electronic skin and health monitoring
    Gregor Schwartz
    Department of Chemical Engineering, Stanford University, 381 North South Mall, Stanford, California 94305, USA
    Nat Commun 4:1859. 2013
    Flexible pressure sensors are essential parts of an electronic skin to allow future biomedical prostheses and robots to naturally interact with humans and the environment...
  21. ncbi Mechanics of nectar feeding in the orchid bee Euglossa imperialis: pressure, viscosity and flow
    Brendan J Borrell
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    J Exp Biol 209:4901-7. 2006
    ..I tested how nectar properties influence this suction pressure and whether ambient air pressure sets the upper limit for suction feeding...
  22. doi Tongue pressure modulation during swallowing: water versus nectar-thick liquids
    Catriona M Steele
    Toronto Rehabilitation Institute, Toronto, ON M5G 2A2, Canada
    J Speech Lang Hear Res 53:273-83. 2010
    Evidence of tongue-palate pressure modulation during swallowing between thin and nectar-thick liquids stimuli has been equivocal...
  23. doi Correlations between controlled endotracheal tube cuff pressure and postprocedural complications: a multicenter study
    Jianhui Liu
    Department of Anesthesiology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China
    Anesth Analg 111:1133-7. 2010
    ..In this study, we investigated the short-term (hours) impact of measuring and controlling endotracheal tube cuff (ETTc) pressure on postprocedural complications.
  24. doi Sound detection by the longfin squid (Loligo pealeii) studied with auditory evoked potentials: sensitivity to low-frequency particle motion and not pressure
    T Aran Mooney
    Marine Biological Laboratory, Woods Hole, MA 02543, USA
    J Exp Biol 213:3748-59. 2010
    ..Sound field pressure and particle motion components were measured from 30 to 10,000 Hz and acceleration stimuli were measured from 20 ..
  25. pmc Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload
    Norimichi Koitabashi
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Clin Invest 121:2301-12. 2011
    The cardiac pathological response to sustained pressure overload involves myocyte hypertrophy and dysfunction along with interstitial changes such as fibrosis and reduced capillary density...
  26. pmc Sensing pressure distribution on a lower-limb exoskeleton physical human-machine interface
    Stefano Marco Maria De Rossi
    ARTS Lab, Scuola Superiore Sant Anna, Viale Rinaldo Piaggio 34, 56025, Pontedera Pi, Italy
    Sensors (Basel) 11:207-27. 2011
    A sensory apparatus to monitor pressure distribution on the physical human-robot interface of lower-limb exoskeletons is presented...
  27. pmc Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling
    Hong Wei
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 109:E841-50. 2012
    Chronic systemic hypertension causes cardiac pressure overload leading to increased myocardial O(2) consumption. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of O(2) homeostasis...
  28. pmc Insights into the ecology and evolutionary success of crocodilians revealed through bite-force and tooth-pressure experimentation
    Gregory M Erickson
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS ONE 7:e31781. 2012
    ..How these factors relate to biomechanical performance during feeding and their relevance to crocodilian evolutionary success are not known...
  29. doi Sensing pressure with ion channels
    Bernd Nilius
    Laboratory of Ion Channel Research, Department of Cell and Molecular Medicine, Katholieke Universiteit KU Leuven, Campus Gasthuisberg, O and N 1, Herestraat 49 bus 802, B 3000 Leuven, Belgium
    Trends Neurosci 35:477-86. 2012
    ..These recent findings allow a better understanding of the molecular basis of molecular and cellular mechanotransduction...
  30. pmc A flexible sensor technology for the distributed measurement of interaction pressure
    Marco Donati
    The BioRobotics Institute, Scuola Superiore Sant Anna, Viale Rinaldo Piaggio 34, 56025 Pontedera PI, Italy
    Sensors (Basel) 13:1021-45. 2013
    We present a sensor technology for the measure of the physical human-robot interaction pressure developed in the last years at Scuola Superiore Sant'Anna...
  31. doi Creep behavior of the intact and meniscectomy knee joints
    M Kazemi
    Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive, NW, Calgary, Alberta, Canada T2N 1N4
    J Mech Behav Biomed Mater 4:1351-8. 2011
    ..was in agreement with published studies, but also altered the distribution and the rate of dissipation of fluid pressure in the cartilages...
  32. pmc Intra-abdominal pressure alterations after large pancreatic pseudocyst transcutaneous drainage
    Theodossis S Papavramidis
    1st Propedeutic Department of Surgery, AHEPA University Hospital, Aristotle s University of Thessaloniki, Macedonia, Greece
    BMC Gastroenterol 9:42. 2009
    ..Aims of the present study were to evaluate the intra-abdominal pressure (IAP) induced by large pancreatic pseudocysts and to examine the effect of their transcutaneous drainage on IAP.
  33. pmc Pressure-induced metallization of silane
    Xiao Jia Chen
    Geophysical Laboratory, Carnegie Institution of Washington, Washington, DC 20015, USA
    Proc Natl Acad Sci U S A 105:20-3. 2008
    ..Here we report measurements of Raman and infrared spectra of silane under pressure. We find that SiH(4) undergoes three phase transitions before becoming opaque at 27-30 GPa...
  34. ncbi Isolation of a gene regulated by hydrostatic pressure in a deep-sea bacterium
    D Bartlett
    The Agouron Institute, La Jolla, CA 92037
    Nature 342:572-4. 1989
    ..and the specific functional modifications and regulatory mechanisms which govern adaptation to hydrostatic pressure are beginning to be understood...
  35. ncbi Pharyngeal mucosal pressure and perfusion: a fiberoptic evaluation of the posterior pharynx in anesthetized adult patients with a modified cuffed oropharyngeal airway
    J Brimacombe
    Department of Anesthesia and Intensive Care, Cairns Base Hospital, Australia
    Anesthesiology 91:1661-5. 1999
    ..The authors assess the relation between pharyngeal mucosal perfusion and directly measured mucosal pressure (MP) in the posterior pharynx using a fiberoptic technique with a modified cuffed oropharyngeal airway (COPA)...
  36. ncbi Pain elicited by blunt pressure: neurobiological basis and clinical relevance
    R D Treede
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstrasse 21, D 55099, Mainz, Germany
    Pain 98:235-40. 2002
  37. ncbi High-speed pressure clamp
    Stephen R Besch
    Center for Single Molecule Biophysics, 320 Cary Hall, SUNY at Buffalo, Buffalo, NY 14214, USA
    Pflugers Arch 445:161-6. 2002
    We built a high-speed, pneumatic pressure clamp to stimulate patch-clamped membranes mechanically...
  38. pmc Influence of a dynamic stabilisation system on load bearing of a bridged disc: an in vitro study of intradiscal pressure
    W Schmoelz
    Institute for Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstr 14, 89081, Ulm, Germany
    Eur Spine J 15:1276-85. 2006
    ..Intradiscal pressure (IDP) measurements were used to assess the load bearing of the bridged disc...
  39. doi Vein recovery from embolism occurs under negative pressure in leaves of sunflower (Helianthus annuus)
    Andrea Nardini
    Dipartimento di Biologia, Universita di Trieste, Via L Giorgieri 10, 34127 Trieste, Italy
    Physiol Plant 133:755-64. 2008
    ..embolism reversal should not be possible until xylem pressures rise by several kilopascals of atmospheric pressure, but recent evidence suggests that embolized conduits can be refilled even when surrounded by others at ..
  40. pmc Use of pressure offloading devices in diabetic foot ulcers: do we practice what we preach?
    Stephanie C Wu
    Scholl s Center for Lower Extremity Ambulatory Research, Rosalind Franklin Universityof Medicine and Science, North Chicago, Illinois, USA
    Diabetes Care 31:2118-9. 2008
    b>Pressure mitigation is crucial for the healing of plantar diabetic foot ulcers. We therefore discuss characteristics and considerations associated with the use of offloading devices.
  41. doi Cold-induced limb pain decreases sensitivity to pressure-pain sensations in the ipsilateral forehead
    Lone Knudsen
    School of Psychology, Murdoch University, South Street, Perth, Murdoch, WA 6150, Australia
    Eur J Pain 13:1023-9. 2009
    ..In the first experiment, pressure-pain thresholds and sharpness sensations were assessed on each side of the forehead in 45 healthy volunteers ..
  42. doi Interstitial fluid pressure as a prognostic factor in cervical cancer following radiation therapy
    Seung Gu Yeo
    Department of Radiation Oncology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea
    Clin Cancer Res 15:6201-7. 2009
    To investigate tumor interstitial fluid pressure as a prognostic factor for recurrence-free survival in patients with cervical cancer following radiation therapy.
  43. pmc Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma
    Agnieszka Kłosowska-Wardega
    Biomedical Center, Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden
    PLoS ONE 4:e8149. 2009
    Elevation of the interstitial fluid pressure (IFP) of carcinoma is an obstacle in treatment of tumors by chemotherapy and correlates with poor drug uptake...
  44. doi Variability among electronic cigarettes in the pressure drop, airflow rate, and aerosol production
    Monique Williams
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    Nicotine Tob Res 13:1276-83. 2011
    ..This study investigated the performance of electronic cigarettes (e-cigarettes), compared different models within a brand, compared identical copies of the same model within a brand, and examined performance using different protocols...
  45. pmc Contributions of turgor pressure, the contractile ring, and septum assembly to forces in cytokinesis in fission yeast
    Stephen A Proctor
    Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Curr Biol 22:1601-8. 2012
    ..Fission yeast, like other walled cells, also possess high (MPa) turgor pressure. Here, we show that turgor pressure is an important factor in the mechanics of cytokinesis...
  46. ncbi Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice
    Ronglih Liao
    Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 106:2125-31. 2002
    ..Although these changes have been considered part of the fetal gene reactivation program, the functional significance of increased glucose utilization in hypertrophied and failing myocardium is poorly understood...
  47. pmc Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload
    Hongliang Li
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Proc Natl Acad Sci U S A 107:13818-23. 2010
    ..inhibition of MEK-ERK1/2 signaling, whereas the Rgs5-/- mice displayed the opposite phenotype in response to pressure overload...
  48. ncbi The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans
    Roger B Fillingim
    University of Florida College of Dentistry, Gainesville, FL 32610, USA
    J Pain 6:159-67. 2005
    ..Statistical analyses indicated that subjects with a rare allele had significantly higher pressure pain thresholds than those homozygous for the common allele...
  49. ncbi Comparison of simultaneous continuous intracranial pressure (ICP) signals from a Codman and a Camino ICP sensor
    Per Kristian Eide
    Department of Neurosurgery, The National Hospital Rikshospitalet, 0027 Oslo, Norway
    Med Eng Phys 28:542-9. 2006
    Simultaneous continuous intracranial pressure (ICP) signals from two different sensors were compared. Continuous ICP monitoring from two ICP sensors (i.e...
  50. doi Low-power wireless micromanometer system for acute and chronic bladder-pressure monitoring
    Steve J A Majerus
    Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA
    IEEE Trans Biomed Eng 58:763-7. 2011
    This letter describes the design, fabrication, and testing of a wireless bladder-pressure-sensing system for chronic, point-of-care applications, such as urodynamics or closed-loop neuromodulation...
  51. doi Continuous control of tracheal cuff pressure and microaspiration of gastric contents in critically ill patients
    Saad Nseir
    Intensive Care Unit, Biochemistry Division, Pathology and Biology Center, University Hospital of Lille, France
    Am J Respir Crit Care Med 184:1041-7. 2011
    ....
  52. doi Supersonic shear wave elastography of in vivo pig kidney: influence of blood pressure, urinary pressure and tissue anisotropy
    Jean Luc Gennisson
    Institut Langevin Ondes et Images, ESPCI ParisTech, CNRS UMR7587, INSERM U979, Paris, France
    Ultrasound Med Biol 38:1559-67. 2012
    The in vivo influence of renal anisotropy and of urinary and vascular pressure on elasticity values using ultrasonic supersonic shear wave elastography was studied in pigs...
  53. ncbi Effect of prosthetic gel liner thickness on gait biomechanics and pressure distribution within the transtibial socket
    Erin Boutwell
    Northwestern University Prosthetics Orthotics Center for Education and Research, Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Rehabil Res Dev 49:227-40. 2012
    ..b>Pressure and quantitative gait data were acquired while subjects walked on liners of two different uniform thicknesses...
  54. doi Key stabilizing elements of protein structure identified through pressure and temperature perturbation of its hydrogen bond network
    Lydia Nisius
    Division of Structural Biology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Nat Chem 4:711-7. 2012
    ..quantitative characterization of protein hydrogen bonds as a function of the basic thermodynamic parameters of pressure and temperature...
  55. ncbi The effect of taste and palatability on lingual swallowing pressure
    Cathy A Pelletier
    Department of Communication Sciences and Disorders, Syracuse University, New York, USA
    Dysphagia 21:121-8. 2006
    ..versus high taste concentrations (sweet, sour, salty, bitter) and barium taste samples on lingual swallowing pressure in ten healthy young adults, using a three-bulb lingual pressure array secured to the hard palate...
  56. doi A comparison of surface acquired uterine electromyography and intrauterine pressure catheter to assess uterine activity
    Gabi Haran
    Department of Obstetrics and Gynecology, Maternal Fetal Unit, Meir Medical Center, Kfar Saba, Affiliated with Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Obstet Gynecol 206:412.e1-5. 2012
    Intrauterine pressure catheter (IUPC) is the primary device used to evaluate uterine activity. In contrast to the IUPC, electrical uterine myography (EUM) enables noninvasive measurement of frequency, intensity, and tone of contractions...
  57. ncbi Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats
    Fumitaka Kuwahara
    Cardiovascular Research Institute and Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    Circulation 106:130-5. 2002
    Excessive myocardial fibrosis impairs cardiac function in hypertensive hearts. Roles of transforming growth factor (TGF)-beta in myocardial remodeling and cardiac dysfunction were examined in pressure-overloaded rats.
  58. ncbi Effects of compost and phosphate on plant arsenic accumulation from soils near pressure-treated wood
    Xinde Cao
    Soil and Water Science Department, University of Florida, Gainesville, FL, USA
    Environ Pollut 132:435-42. 2004
    ..Caution should be taken for phosphate application since it enhances As accumulation...
  59. ncbi Effects of shoe inserts and heel height on foot pressure, impact force, and perceived comfort during walking
    Lee Yung-Hui
    Department of Industrial Management, National Taiwan University of Science and Technology, No 43, Kee Lung Road, Sec IV, Taipei, Taiwan, 106 ROC
    Appl Ergon 36:355-62. 2005
    ..The purpose of this study was to determine whether increasing heel height and the use of shoe inserts change foot pressure distribution, impact force, and perceived comfort during walking. Ten healthy females volunteered for the study...
  60. ncbi Forefoot joint damage, pain and disability in rheumatoid arthritis patients with foot complaints: the role of plantar pressure and gait characteristics
    M Van Der Leeden
    Jan van Breemen Institute, Center for Rehabilitation and Rheumatology, Jan van Breemenstraat 2, 1056 AB Amsterdam, The Netherlands
    Rheumatology (Oxford) 45:465-9. 2006
    To assess (i) the relationship between forefoot joint damage and foot function (expressed as gait and pressure parameters), (ii) the relationship between foot function and pain, and (iii) the relationship between foot function and ..
  61. pmc Lateral pressure profile, spontaneous curvature frustration, and the incorporation and conformation of proteins in membranes
    Derek Marsh
    Max Planck Institut fur biophysikalische Chemie, Abt Spektroskopie, Gottingen, Germany
    Biophys J 93:3884-99. 2007
    ..interactions at the lipid-protein interface, global interactions such as the distribution of internal lateral pressure may also influence protein conformation...
  62. pmc Interstitial fluid pressure, vascularity and metastasis in ectopic, orthotopic and spontaneous tumours
    Sarah Jane Lunt
    Ontario Cancer Institute, Princess Margaret Hospital, University of Toronto, 610 University Ave, Toronto, Ontario, M5G 2M9, Canada
    BMC Cancer 8:2. 2008
    High tumour interstitial fluid pressure (IFP) has been adversely linked to poor drug uptake in patients, and to treatment response following radiotherapy in cervix cancer patients...
  63. doi The effectiveness of pressure garment therapy for the prevention of abnormal scarring after burn injury: a meta-analysis
    Alexander Anzarut
    Division of Plastic and Reconstructive Surgery, University of Alberta, Edmonton, Alberta, Canada
    J Plast Reconstr Aesthet Surg 62:77-84. 2009
    ..First, to conduct a systematic review to identify the available evidence for the use of pressure garment therapy (PGT); second, to assess the quality of the available evidence; and third, to conduct a meta-..
  64. doi A thoracic mechanism of mild traumatic brain injury due to blast pressure waves
    A C Courtney
    Department of Physics, United States Military Academy, West Point, NY 10996, United States
    Med Hypotheses 72:76-83. 2009
    The mechanisms by which blast pressure waves cause mild-to-moderate traumatic brain injury (mTBI) are an open question...
  65. doi The alpha11beta1 integrin has a mechanistic role in control of interstitial fluid pressure and edema formation in inflammation
    Ø S Svendsen
    Department of Anesthesia and Intensive Care, Haukeland University Hospital, Department of Biomedicine, University of Bergen, Bergen, Norway
    Arterioscler Thromb Vasc Biol 29:1864-70. 2009
    Collagen-binding integrins may be involved in controlling interstitial fluid pressure (Pif), transcapillary fluid flux, and tissue fluid volume...
  66. doi Rethinking sound detection by fishes
    Arthur N Popper
    Department of Biology and Center for Comparative and Evolutionary Biology of Hearing, University of Maryland, College Park, MD 20742, USA
    Hear Res 273:25-36. 2011
    ..Moreover, any possible pressure sensitivity is the result of the presence of an air bubble (e.g...
  67. ncbi MG132, a proteasome inhibitor, attenuates pressure-overload-induced cardiac hypertrophy in rats by modulation of mitogen-activated protein kinase signals
    Baolin Chen
    Department of Cardiology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Acta Biochim Biophys Sin (Shanghai) 42:253-8. 2010
    ..In conclusion, our results suggested that long-term treatment with MG132 attenuates pressureoverload-induced cardiac hypertrophy and improves cardiac function in AAB rats through regulation of ERK1/2 and JNK1 signaling pathways...
  68. pmc Sound pressure transformations by the head and pinnae of the adult Chinchilla (Chinchilla lanigera)
    Kanthaiah Koka
    Department of Physiology and Biophysics, University of Colorado Medical School, Aurora, CO, USA
    Hear Res 272:135-47. 2011
    ..and psychophysics of audition, including binaural and spatial hearing, little is actually known about the sound pressure transformations by the head and pinnae and the resulting sound localization cues available to them...
  69. doi Reduced tongue pressure against the hard palate on the paralyzed side during swallowing predicts Dysphagia in patients with acute stroke
    Nobuko Hirota
    Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan
    Stroke 41:2982-4. 2010
    ..The present study investigated the relationship between tongue motor deficits and dysphagia in patients with acute stroke...
  70. pmc Pressure-induced superconductivity in topological parent compound Bi2Te3
    J L Zhang
    Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China
    Proc Natl Acad Sci U S A 108:24-8. 2011
    We report a successful observation of pressure-induced superconductivity in a topological compound Bi(2)Te(3) with T(c) of ∼3 K between 3 to 6 GPa...
  71. doi Investigation of hemodynamics in the development of dissecting aneurysm within patient-specific dissecting aneurismal aortas using computational fluid dynamics (CFD) simulations
    Kwong Ming Tse
    Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore
    J Biomech 44:827-36. 2011
    ..of dissecting aneurysm, hemodynamic parameters including flow pattern, velocity distribution, aortic wall pressure and shear stress, which are difficult to measure in vivo, are evaluated using numerical simulations...
  72. pmc Evaluation and optimization of therapeutic footwear for neuropathic diabetic foot patients using in-shoe plantar pressure analysis
    Sicco A Bus
    Department of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Diabetes Care 34:1595-600. 2011
    Therapeutic footwear for diabetic foot patients aims to reduce the risk of ulceration by relieving mechanical pressure on the foot. However, footwear efficacy is generally not assessed in clinical practice...
  73. doi Foot center of pressure manipulation and gait therapy influence lower limb muscle activation in patients with osteoarthritis of the knee
    Yulia Goryachev
    Faculty of Mechanical Engineering, Technion Israel Institute of Technology, Haifa, Israel
    J Electromyogr Kinesiol 21:704-11. 2011
    Foot center of pressure (COP) manipulation has been associated with improved gait patterns...
  74. doi Influence of obesity and gender on the postural stability during upright stance
    Nora S Cruz-Gómez
    Unidad de Investigación Médica en Otoneurología, Mexico D F, Mexico
    Obes Facts 4:212-7. 2011
    ..To assess the influence of BMI group (lean/overweight/obese) and gender on the postural sway of adults and adolescents during quiet upright stance...
  75. pmc Phloem ultrastructure and pressure flow: Sieve-Element-Occlusion-Related agglomerations do not affect translocation
    Daniel R Froelich
    School of Biological Sciences, Washington State University, Pullman, Washington 99164 4236, USA
    Plant Cell 23:4428-45. 2011
    ..injury, the lumen of sieve tubes is free of obstructions, and phloem flow is driven by an osmotically generated pressure differential according to Münch's classical hypothesis...
  76. doi Measurement of intra-abdominal pressure in term pregnancy: a pilot study
    R Chun
    Department of Anesthesia, Foothills Medical Center, AlbertaHealth Services, Calgary, Alberta, Canada
    Int J Obstet Anesth 21:135-9. 2012
    This study was conducted to assess the feasibility of measuring intra-abdominal pressure in term parturients under spinal anesthesia.
  77. doi Genetic adaptation of the hypoxia-inducible factor pathway to oxygen pressure among eurasian human populations
    Lin dan Ji
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    Mol Biol Evol 29:3359-70. 2012
    ..thus, whether a common adaptive mechanism exists in response to quantitative variations of environmental oxygen pressure over a wide range of residing altitudes is unknown...
  78. doi FIB/SEM tomography with TEM-like resolution for 3D imaging of high-pressure frozen cells
    Clarissa Villinger
    Central Facility for Electron Microscopy, Ulm University, 89069 Ulm, Germany
    Histochem Cell Biol 138:549-56. 2012
    ..High-pressure freezing and freeze substitution, on the other hand, are the gold standards for electron microscopic preparation ..
  79. pmc Foot type biomechanics part 1: structure and function of the asymptomatic foot
    Howard J Hillstrom
    Leon Root M D Motion Analysis Laboratory, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, United States
    Gait Posture 37:445-51. 2013
    ..Many foot pathologies are of a biomechanical nature and often associated with foot type. Fundamental to the understanding of foot pathomechanics is the question: do different foot types have distinctly different structure and function?..
  80. pmc Tourniquet cuff pressure and nerve injury in knee arthroplasty in a bloodless field: a neurophysiological study
    Charlotta Olivecrona
    Orthopedics Section, Department of Clinical Science and Education, Sodersjukhuset, Sweden
    Acta Orthop 84:159-64. 2013
    ..We describe the results of neurophysiological examinations and report the incidence of nerve injuries after total knee arthroplasty (TKA) in a bloodless field...
  81. ncbi Intrasession reliability of center of pressure measures of postural steadiness in healthy elderly people
    Danik Lafond
    Department of Kinesiology, University of Montreal, Downtown Station, Montreal, Quebec H3C 3J7, Canada
    Arch Phys Med Rehabil 85:896-901. 2004
    To estimate the immediate test-retest reliability of a single measure of several center of pressure (COP) variables, to report the number of trials to be averaged to obtain a reliable measurement of postural steadiness, and to determine ..
  82. pmc Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring
    D Sifrim
    Faculty of Medicine, KU Leuven, Lab G I Physiopathology, O and N Gasthuisberg, 7th Floor, Herestraat 49, 3000, Leuven, Belgium
    Gut 54:449-54. 2005
    ..Less acidic reflux may produce symptoms such as regurgitation or chest pain. We investigated whether chronic cough might be associated with weakly acidic reflux...
  83. ncbi Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation
    Cornelia M Keck
    PharmaSol GmbH, Berlin, Germany
    Eur J Pharm Biopharm 62:3-16. 2006
    ..by bottom up techniques (precipitation) is briefly described, main focus is given on particle diminution by high pressure homogenisation...
  84. doi A psychophysical study of auditory and pressure sensitivity in patients with fibromyalgia and healthy controls
    Michael E Geisser
    Chronic Pain and Fatigue Research Center, Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan 48108, USA
    J Pain 9:417-22. 2008
    ..We hypothesized that subjects with FM would display greater sensitivity to both pressure and auditory tones and report greater sensitivity to sounds encountered in daily activities...
  85. doi The impact of body position on intra-abdominal pressure measurement: a multicenter analysis
    Michael L Cheatham
    Department of Surgical Education, Orlando Regional Medical Center, Orlando, FL, USA
    Crit Care Med 37:2187-90. 2009
    Elevated intra-abdominal pressure (IAP) is a frequent cause of morbidity and mortality among the critically ill. IAP is most commonly measured using the intravesicular or "bladder" technique...
  86. doi Gender differences in pressure-natriuresis and renal autoregulation: role of the Angiotensin type 2 receptor
    Lucinda M Hilliard
    Department of Physiology, Monash University, Victoria, Australia, 3800
    Hypertension 57:275-82. 2011
    Sexual dimorphism in arterial pressure regulation has been observed in humans and animal models. The mechanisms underlying this gender difference are not fully known...
  87. doi Does femoral venous pressure measurement correlate well with intrabladder pressure measurement? A multicenter observational trial
    Bart L De Keulenaer
    Intensive Care Unit, Fremantle Hospital, 1 Alma Street, Fremantle, WA 6160, Australia
    Intensive Care Med 37:1620-7. 2011
    To investigate if femoral venous pressure (FVP) measurement can be used as a surrogate measure for intra-abdominal pressure (IAP) via the bladder.
  88. pmc Application of supercritical antisolvent method in drug encapsulation: a review
    Mahshid Kalani
    Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, Malaysia
    Int J Nanomedicine 6:1429-42. 2011
    ..polymeric controlled release system, and discusses the effects of the various conditions in the process, such as pressure, temperature, concentration, chemical compositions (organic solvents, drug, and biodegradable polymer), nozzle ..
  89. pmc Role of membrane fluidity in pressure resistance of Escherichia coli NCTC 8164
    M A Casadei
    School of Food Biosciences, University of Reading, Whiteknights, United Kingdom
    Appl Environ Microbiol 68:5965-72. 2002
    The relationship among growth temperature, membrane fatty acid composition, and pressure resistance was examined in Escherichia coli NCTC 8164...
  90. ncbi The role of limited joint mobility in diabetic patients with an at-risk foot
    Stefan Zimny
    Evangelisches Krankenhaus Bethesda, Akademisches Lehrkrankenhaus der Universität Düsseldorf, Medizinische Klinik I, Duisburg, Germany
    Diabetes Care 27:942-6. 2004
    ..To assess the role of limited joint mobility (LJM) in causing abnormal high plantar pressures in the forefoot of diabetic patients with an at-risk foot...
  91. pmc A large-area, flexible pressure sensor matrix with organic field-effect transistors for artificial skin applications
    Takao Someya
    Quantum Phase Electronics Center, School of Engineering, University of Tokyo, Tokyo 113 8656, Japan
    Proc Natl Acad Sci U S A 101:9966-70. 2004
    ..Despite this fact, relatively little progress has been made in the field of pressure recognition compared to the areas of sight and voice recognition, mainly because good artificial "electronic skin"..
  92. ncbi Predicting the outcome of prostatectomy using noninvasive bladder pressure and urine flow measurements
    Christopher Harding
    Department of Urology, Freeman Hospital, Newcastle upon Tyne, UK
    Eur Urol 52:186-92. 2007
    To determine whether categorisation of bladder outlet obstruction (BOO) using measurements of bladder pressure and urine flow obtained by a novel noninvasive medical device (the penile cuff test) improves prediction of outcome from ..
  93. pmc Regulator or driving force? The role of turgor pressure in oscillatory plant cell growth
    Jens H Kroeger
    Department of Physiology, Centre for Nonlinear Dynamics, McGill University, Montreal, Quebec, Canada
    PLoS ONE 6:e18549. 2011
    ..An analytic analysis of our model demonstrates in which regime the average growth rate becomes uncorrelated from the turgor pressure.
  94. pmc Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload
    Jérôme Piquereau
    INSERM, U 769, Faculte de Pharmacie, Universite Paris Sud, 5 rue J B Clement, F 92296 Chatenay Malabry, France
    Cardiovasc Res 94:408-17. 2012
    ..Despite its high level of expression, the role of OPA1 in the heart is largely unknown. We investigated the role of this protein in Opa1(+/-) mice, having a 50% reduction in OPA1 protein expression in cardiac tissue...
  95. ncbi Synergistic interaction and the role of C-terminus in the activation of TRAAK K+ channels by pressure, free fatty acids and alkali
    Y Kim
    Department of Physiology and Biophysics, Finch University of Health Sciences, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Pflugers Arch 442:64-72. 2001
    ..we studied its single-channel kinetics, interactive modes of activation, and the role of the C-terminus on its pressure-, fatty-acid- and pH-sensitivity...
  96. ncbi Estimation of inspiratory pressure drop in neonatal and pediatric endotracheal tubes
    P H Jarreau
    Service de Medecine Neonatale, Centre Hospitalier Universitaire Cochin Port Royal, Assistance Publique Hopitaux de Paris Université Paris V, 75014 Paris, France
    J Appl Physiol (1985) 87:36-46. 1999
    Endotracheal tubes (ETTs) constitute a resistive extra load for intubated patients. The ETT pressure drop (DeltaP(ETT)) is usually described by empirical equations that are specific to one ETT only...
  97. ncbi Clinical and physiological findings, and possible aetiological factors of rectal hyposensitivity
    M A Gladman
    Academic Department of Surgery and Gastrointestinal Physiology Unit, St Bartholomew s and the London School of Medicine and Dentistry, London, UK
    Br J Surg 90:860-6. 2003
    ..Rectal hyposensitivity (RH) relates to insensitivity of the rectum on anorectal physiological investigation and appears common in functional bowel disorders. The clinical significance of this physiological abnormality is unclear...
  98. ncbi Muscle synergies during shifts of the center of pressure by standing persons: identification of muscle modes
    Vijaya Krishnamoorthy
    Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
    Biol Cybern 89:152-61. 2003
    ..Four tasks required the subjects to release a load from extended arms leading to a center of pressure (COP) shift prior to the load release. The fifth task required an explicit COP shift by voluntary sway...
  99. ncbi Rectal hyposensitivity: a disorder of the rectal wall or the afferent pathway? An assessment using the barostat
    Marc A Gladman
    Centre for Academic Surgery Gastrointestinal Physiology Unit, Barts and The London, Queen Mary s School of Medicine and Dentistry, Whitechapel, London E1 1BB, United Kingdom
    Am J Gastroenterol 100:106-14. 2005
    ..The aim of this study was to investigate whether RH was actually due to impaired afferent nerve function or whether it could be secondary to abnormalities of the rectal wall...
  100. doi Tongue movement and intra-oral vacuum in breastfeeding infants
    Donna T Geddes
    The University of Western Australia, Biochemistry and Molecular Biology, School of Biomedical, Biomolecular and Chemical Sciences, Faculty of Life and Physical Sciences, Australia
    Early Hum Dev 84:471-7. 2008
    ..The aim of this study was to use ultrasound to observe movements of the tongue during breastfeeding and relate these movements to both milk flow and simultaneous measurements of intra-oral vacuum...
  101. doi Age-related differences in pain sensitivity and regional brain activity evoked by noxious pressure
    Leonie J Cole
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Neurobiol Aging 31:494-503. 2010
    ..the effects of ageing on supraspinal pain processing by comparing regional brain responses to noxious pressure stimulation in 15 young (aged 26+/-3 years) and 15 older (aged 79+/-4 years) adults...

Research Grants84

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..and photography: The examination measures visual acuity, thickness of your retina (the back of the eye) andeye pressure. Bright lights will also be used so that the doctor can see the back of your eye...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..and photography: The examination measures visual acuity, thickness of your retina (the back of the eye) andeye pressure. Bright lights will also be used so that the doctor can see the back of your eye...
  3. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  4. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  5. Yasmin Wadia; Fiscal Year: 2014
    ..Laser tissue welding (LTW) is an enhanced non-compressive and non-ablative surgical capability that can seal low pressure fluid leaks instantly and accurately, including blood, gastrointestinal fluids, urine, bile, lymph, and ..
  6. Jill M Wecht; Fiscal Year: 2014
    ..from repetitive apneic events, although falls in cardiac output that accompany large negative intrathoracic pressure swings, and repetitive hypoxia/reoxygenation associated with oxidative stress and endothelial dysfunction have ..
  7. Noreen F Rossi; Fiscal Year: 2016
    ..meeting the 7th Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC7) recommendation of arterial pressure <140/90 mmHg...
  8. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..We have identified that chromogranin A (Chga)-derived peptide, catestatin (CST), lowers blood pressure (BP) and heart rate (HR) by inhibiting release of catecholamines...
  9. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    ..Metabolic syndrome components (blood pressure, lipids, glucose, anthropometrics), the prevalence of mood disorders, medical history, and health behaviors will ..
  10. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ..These findings were not the result of either the reduction of blood pressure since triple therapy (A/I + T2) did not normalize QO2/TNa nor did the increase in GFR that accompanies AII ..
  11. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..a strong association between OSA and diabetes, it remains unclear today whether continuous positive airway pressure (CPAP) treatment of OSA can significantly improve glucose control...
  12. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..evidence supports a J- or U-shaped association between alcohol consumption and heart attack and/or high blood pressure. As such, while light-to-moderate drinking has been associated with protection from heart disease, heavy drinking ..
  13. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..Aim #4: Over a 4 h period, we will monitor peripheral arterial blood pressure and heart rate in anesthetized endotoxinemic mice treated with vehicle control or R-100 administered 1 h after ..
  14. Patrice G Guyenet; Fiscal Year: 2015
    ..The contribution of the C1 neurons to blood pressure stabilization, including during hypoxia, is well established, thanks in part to our work...
  15. Ming Zhou; Fiscal Year: 2014
    ..show reduced ability to absorb water, and genetic variations of human UT are directly linked to abnormal blood pressure. These results indicate that UT plays an important role in kidney physiology and in regulating blood pressure...
  16. CLIFFORD RUSSELL GREYSON; Fiscal Year: 2016
    ..The overall goal of this project is to identify the mechanism by which acute RV pressure overload causes calpain activation and right ventricular contractile dysfunction during and following acute RV ..
  17. JAMES RUSSELL SOWERS; Fiscal Year: 2015
    ..5 mg/kg/day, a dose determined by telemetry to have no effect on blood pressure in db/db mice...
  18. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..with a number of metabolic and cardiovascular disease risk factors including insulin resistance, high blood pressure and dysregulation of lipid and glucose metabolism...
  19. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..by applicant): Metabolic syndrome (Metsyn) is a condition of coexisting abnormalities in glucose, lipid, blood pressure, and body fat homeostasis, that affects more than half of U.S. adults 55 years and older...
  20. RALPH FRANK FREGOSI; Fiscal Year: 2016
    ..vivo, due to reduced tongue muscle activation and diminished neuromuscular responses to changes in upper airway pressure. For these studies we will use lightly anesthetized neonatal rat pups wherein measurements of rib cage expansion ..
  21. REGULATION AND FUNCTION OF STE20-RELATED PROTEIN KINASES
    Melanie H Cobb; Fiscal Year: 2012
    ..Mutations in either WNK1 or WNK4 cause pseudohypoaldosteronism type II (PHA II), a form of high blood pressure caused by mutation of a single gene...
  22. Mark W Chapleau; Fiscal Year: 2015
    ..While the role of vascular CGRP receptors is well recognized, the role of nervous system CGRP receptors in blood pressure regulation remains unclear...
  23. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    ..CAD risk factors include high blood pressure, high cholesterol and diabetes...
  24. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..Aim 2: will determine the contribution of increased autophagic flux to adverse cardiac remodeling following pressure overload or ischemic injury in genetically insulin resistant hearts or in hearts from mice with type 1 or type 2 ..
  25. Paul J Shami; Fiscal Year: 2014
    ..bone marrow cells, but until now has not been used directly to treat cancer because of its effect to lower blood pressure. JSK Therapeutics (JSKT) has designed a class of diazeniumdiolate prodrugs that release NO upon interaction with ..
  26. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ..the development of hypertension, suggesting a critical role for PGE2 in the maintenance of Na balance and blood pressure. In addition, salt-sensitive hypertension is associated with and linked to deficiencies in renal PGE2 synthesis ..
  27. Samuel D Crish; Fiscal Year: 2016
    ..compared to two major risk factors in glaucoma: age (DBA/2J mice) and exposure to elevated intraocular pressure (Microbead Occlusion Model)...
  28. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
    ..In response to pressure overload there is an increase ECM production while in the pure VO there is a decrease in ECM...
  29. Junichi Sadoshima; Fiscal Year: 2016
    ..of GSK-3a and S9 phosphorylation GSK-3b exhibited opposite functional consequences in the heart under pressure overload, indicating the importance of re-evaluating the function of the GSK-3 isoforms with special emphasis on ..
  30. MATTHEW PETER COGGINS; Fiscal Year: 2014
    ..seeks to investigate the role of IKKB and NF-kB signaling in the heart at baseline and under the stress of pressure overload. The candidate will be under the mentorship of Dr...
  31. AYLIN RACHEL RODAN; Fiscal Year: 2015
    ..ion transport underlies essential kidney functions, such as the regulation of extracellular volume and blood pressure and acid-base regulation...
  32. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    ..Recently, our laboratory identified a novel HTN gene, STK39, from a genome-wide association of baseline blood pressure (BP) in the Old Order Amish, a genetically homogeneous founder population...
  33. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..pleiotropic effects on both serum OC and metabolic risk factors (including waist circumference, systolic blood pressure, fasting triglycerides, fasting HDL cholesterol, fasting plasma glucose, fasting plasma insulin, adiponectin ..
  34. Conference on Autonomic Regulation of Cardiovascular Function in Health and Disea
    Martin Frank; Fiscal Year: 2012
    ..the past 100 years we have acquired a comprehensive understanding of the neural mechanisms that regulate arterial pressure and peripheral resistance...
  35. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ..deposition and down regulation of endothelial nitric oxide - all of which plausibly contribute to elevated blood pressure (BP)and vascular and pressure- sensitive target organ injury, weight gain, dyslipidemia, and glucose intolerance...
  36. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..obstructive sleep apnea severity, be associated with induction of central apneas when continuous positive airway pressure (CPAP) is used for treatment, and possibly impair long term efficacy and tolerance...
  37. ROBERT MARK WIGHTMAN; Fiscal Year: 2016
    ..There are two primary control points. Blood vessels near the brain surface maintain blood pressure in a relatively constant range according to the physiological requirements...
  38. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    Charles S Wingo; Fiscal Year: 2012
    ..Aldosterone acts on the distal nephron and collecting duct to increase Na reabsorption and blood pressure. Results from two recent clinical studies (RALES and EPHESUS) demonstrated that aldosterone blockade reduced ..
  39. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..Efficacy Parameters shall evaluate the number of days on mechanical ventilation and/or nasal positive airway pressure, number of days on supplemental oxygen, and overall morbidity and mortality (%)...
  40. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..Small trails further suggest that EA can lower elevated blood pressure. Studies conducted in the last two grant cycles have evaluated supra-spinal mechanisms underlying EA's ..
  41. Aldosterone Action In The Brain, Hypertension and Inflammation
    ELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012
    ..and antagonists that excessive circulating levels of aldo act through MR of the brain to elevate the blood pressure. Inhibition of MR in brains of Dahl Salt Sensitive hypertensive (SS) rats also mitigates their hypertension, ..
  42. Ken R Smith; Fiscal Year: 2015
    ..dehydroepiandrosterone sulfate (DHEAS &DHEA), fasting glucose and insulin resistance, telomere length, blood pressure, heart rate, grip strength, forced expiratory volume (FEV1), and BMI...
  43. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..on a variety of baby vital signs, including ECG, pulse-ox, skin temperature, motion detection, EPG, and blood pressure. Respiratory rate will derive from ECG readings in combination with EPG and chest motion...
  44. Intrathoracic Pressure Regulator for Resuscitation
    Keith G Lurie; Fiscal Year: 2011
    ..The goal of this SBIR Phase 2 application is to continue the development and evaluation the intrathoracic pressure regulator (ITPR), intended to increase circulation and blood pressure clinically significant states of ..
  45. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    ..physiology will be assessed to determine toxicity of the compounds, and in the case of NO donors blood pressure will also be monitored...
  46. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..increased hemodynamic load;and ischemia due to lack of angiogenesis is observed in decompensation of pressure overload hypertrophy, thus subjecting hearts to both ischemic and hypertrophic stress as a final common pathway...
  47. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..wall is a common denominator of the atherogenic response, with elevated levels of blood cholesterol, high blood pressure, diabetes, and smoking recognized as primary risk factors...
  48. Iris Z Jaffe; Fiscal Year: 2016
    ..by binding to the mineralocorticoid receptor (MR), a ligand-activated transcription factor, to regulate blood pressure (bp)...
  49. Computer/Electrical Engineering
    Theodore Raphan; Fiscal Year: 2011
    ..5. Generate apparatus for heart rate and blood pressure measurements in the rat to determine the impact of the vestibule-sympathetic reflex during changes in head ..
  50. Phillip Darwin Bell; Fiscal Year: 2016
    ..Physiological studies will be performed to assess GFR, blood pressure, and proteinuria, Western blot, immunofluorescence, genomic analysis will be used to evaluate the complex ..
  51. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..provided by applicant): Preeclampsia (PE) is a serious complication of pregnancy manifested by high blood pressure, proteinuria, and edema, sometimes with encephalopathy, seizures, and hepatic failure...
  52. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2013
    ..included demographics, psychosocial inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  53. JACKSON HEART STUDY
    Asoka Srinivasan; Fiscal Year: 2010
    ..included demographics, psychosocial inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  54. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..included demographics, psychosocial inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  55. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..included demographics, psychosocial inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  56. Comparative effectiveness of diabetes prevention strategies in women with GDM
    Assiamira Ferrara; Fiscal Year: 2010
    ..Secondary outcomes will include postpartum glucose levels, blood pressure, depression, dietary fat intake, total calories and PA...
  57. Kenneth J Gustafson; Fiscal Year: 2015
    ..Chronic testing will measure the clinical and bladder pressure impact of the chronic stimulation...
  58. JACKSON HEART STUDY
    Herman Taylor; Fiscal Year: 2010
    ..included demographics, psychosocial inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  59. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2011
    ..included demographics, psychosocial inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  60. The Prevalence of Blood Pressure Abnormalities among Veterans with SCI
    Jill Wecht; Fiscal Year: 2009
    ..Diminished autonomic cardiovascular control following SCI can result in abnormal blood pressure, blood flow and heart rate, the degree of which may or may not be related to the level and completeness of SCI (3,..
  61. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    ..The goal of this SBIR Phase 1 application is to apply a new potentially life-saving therapy, Intrathoracic Pressure Regulation (IPR) recently developed and shown to increase circulation and survival rates in hemorrhagic shock and ..
  62. K-Mg-citrate as a BP lowering agent in African Americans; role of natriuresis
    ROBERT FRANKLIN REILLY; Fiscal Year: 2010
    ..prevalence of obesity and lower dietary potassium intake compared to Caucasians (these factors affect blood pressure), a stronger emphasis on lifestyle modification is justified...
  63. Older Mothers and Adult Daughters: High Blood Pressure Self Management Behaviors
    Celeste Shawler; Fiscal Year: 2010
    ..perceived control, and the quality of the relationship of older mothers and their adult daughters on blood pressure self management behaviors and health related quality of life...
  64. WEARABLE SENSOR FOR CONTINUOUS NONINVASIVE MONITORING OF PULSE PRESSURE
    Sridhar Madala; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Wearable Sensor for Continuous Noninvasive Monitoring of Pulse Pressure Blood pressure and pulse pressure are among the most commonly measured parameters to assess cardiovascular function...
  65. MICROVASCULAR PERMEABILITY OF THE CEREBRAL CIRCULATION
    WILLIAM MAYHAN; Fiscal Year: 1992
    ..and disruption of the BBB in veins was associated with, and presumably due to, increases in pial venous pressure. Experiments that are proposed will examined the determinants of disruption in veins...
  66. CAD-CAM TECHNOLOGY FOR DIABETIC FOOTWEAR
    JOSEPH L LOOMIS; Fiscal Year: 2010
    ..plantar, occurring at points of high plantar loading, so that insoles that redistribute load and therefore reduce pressure should reduce plantar ulcer rates and therefore amputation risk...
  67. THE HIGH PRESSURE ZONE OF THE DISTAL ESOPHAGUS
    Larry Miller; Fiscal Year: 2006
    ..in space and in time; and 2) mechanical interactions in which each component of the LES and CD contributes to the pressure generated at the gastroesophageal junction high-pressure zone (GEJHPZ) individually and in combination...
  68. Telemetric Implantable Intraocular Pressure Sensor Syste
    LAWRENCE WAN; Fiscal Year: 2003
    ..does not allow for real-time, continuous (24/7, diurnal and nocturnal readings) monitoring of intraocular pressure (lOP) to enable physicians to study, diagnose and more clearly understand the response mechanism relating to lOP ..
  69. Chicago Endothelial Function Study
    Louise C Hawkley; Fiscal Year: 2010
    _' High blood pressure is a strong, modifiable, independent risk factor for cardiovascular and renal disease, and was a primary or contributing cause of 11% of U.S. deaths in 2003 (American Heart Association, 2006)...
  70. Thoroughfare Channels in CBF Autoregulation at High ICP
    Edwin M Nemoto; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cerebral edema, hyperemia and elevated intracranial pressure (ICP) frequently occur after stroke, traumatic brain injury, cardiac arrest, hepatic encephalopathy, etc...
  71. Arterial Baroreflex Function in African Americans at Rest and During Exercise
    David Keller; Fiscal Year: 2009
    ..Moreover, normotensive African Americans exhibit exaggerated blood pressure responses to exercise, as well as to various laboratory pressor stimuli (e.g...
  72. CALCIUM INTAKE, METABOLISM & GESTATIONAL BLOOD PRESSURE
    Cynthia Morris; Fiscal Year: 1990
    ..importance of maintaining dietary calcium intake and normal calcium metabolism for optimal regulation of arterial pressure in humans and experimental models has been demonstrated by us and other investigators...
  73. RIGHT VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOAD
    Clifford Greyson; Fiscal Year: 2006
    Right ventricular (RV) contractile failure from acute RV pressure overload is an important cause of morbidity and mortality in conditions such as massive pulmonary embolism, hypoxic pulmonary vasoconstriction, and following ..
  74. Reducing Low-back Disorders Using a New Sitting Design
    Mohsen Makhsous; Fiscal Year: 2003
    ..may cause backward rotation of the pelvis, reduction in lumbar lordosis, changes in muscle activities and disc pressure, excessive pressure over the ischium and coccyx, and certainly the associated LBP...
  75. Experimental Model For Pressure Ulcers In Human Skin: The Role of Aging and ECM
    Marjana Tomic Canic; Fiscal Year: 2009
    ..goal is to develop an in vitro experimental model to study skin tissue changes that lead to impaired healing and pressure ulcers in elderly...