Top Publications

  1. ncbi Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis
    Vicky Buchanan-Wollaston
    Warwick HRI, University of Warwick, Wellesbourne CV35 9EF, UK
    Plant J 42:567-85. 2005
  2. ncbi Rhythmic growth explained by coincidence between internal and external cues
    Kazunari Nozue
    Section of Plant Biology, College of Biological Sciences, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Nature 448:358-61. 2007
  3. ncbi Hedgehog signalling controls eye degeneration in blind cavefish
    Yoshiyuki Yamamoto
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Nature 431:844-7. 2004
  4. pmc Ribosome and transcript copy numbers, polysome occupancy and enzyme dynamics in Arabidopsis
    Maria Piques
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, Potsdam Golm, Germany
    Mol Syst Biol 5:314. 2009
  5. ncbi Molecular basis of seasonal time measurement in Arabidopsis
    Marcelo J Yanovsky
    The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Nature 419:308-12. 2002
  6. ncbi Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage
    Antony N Dodd
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK
    Science 309:630-3. 2005
  7. pmc Evolution of a behavioral shift mediated by superficial neuromasts helps cavefish find food in darkness
    Masato Yoshizawa
    Department of Biology, University of Maryland, College Park, 20742, USA
    Curr Biol 20:1631-6. 2010
  8. ncbi Quantitative x-ray dark-field computed tomography
    M Bech
    Physik Department, Technische Universitat Munchen, 85748 Garching, Germany
    Phys Med Biol 55:5529-39. 2010
  9. pmc Multiple phytochrome-interacting bHLH transcription factors repress premature seedling photomorphogenesis in darkness
    Pablo Leivar
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Curr Biol 18:1815-23. 2008
  10. ncbi Resetting central and peripheral circadian oscillators in transgenic rats
    S Yamazaki
    NSF Center for Biological Timing and Department of Biology, University of Virginia, Charlottesville, VA 22903-2477, USA
    Science 288:682-5. 2000

Detail Information

Publications320 found, 100 shown here

  1. ncbi Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis
    Vicky Buchanan-Wollaston
    Warwick HRI, University of Warwick, Wellesbourne CV35 9EF, UK
    Plant J 42:567-85. 2005
    ..leaf senescence with those identified, when senescence is artificially induced in leaves induced to senesce by darkness or during sucrose starvation-induced senescence in cell suspension cultures, has shown not only similarities but ..
  2. ncbi Rhythmic growth explained by coincidence between internal and external cues
    Kazunari Nozue
    Section of Plant Biology, College of Biological Sciences, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Nature 448:358-61. 2007
    ..This interaction may serve as a paradigm for understanding how endogenous and environmental signals cooperate to control other processes...
  3. ncbi Hedgehog signalling controls eye degeneration in blind cavefish
    Yoshiyuki Yamamoto
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Nature 431:844-7. 2004
    ..These features can be mimicked in surface fish by twhh and/or shh overexpression, supporting the role of hh signalling in the evolution of cavefish eye regression...
  4. pmc Ribosome and transcript copy numbers, polysome occupancy and enzyme dynamics in Arabidopsis
    Maria Piques
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, Potsdam Golm, Germany
    Mol Syst Biol 5:314. 2009
    Plants are exposed to continual changes in the environment. The daily alternation between light and darkness results in massive recurring changes in the carbon budget, and leads to widespread changes in transcript levels...
  5. ncbi Molecular basis of seasonal time measurement in Arabidopsis
    Marcelo J Yanovsky
    The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Nature 419:308-12. 2002
  6. ncbi Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage
    Antony N Dodd
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK
    Science 309:630-3. 2005
    ..This explains why plants gain advantage from circadian control...
  7. pmc Evolution of a behavioral shift mediated by superficial neuromasts helps cavefish find food in darkness
    Masato Yoshizawa
    Department of Biology, University of Maryland, College Park, 20742, USA
    Curr Biol 20:1631-6. 2010
    How cave animals adapt to life in darkness is a poorly understood aspect of evolutionary biology [1]...
  8. ncbi Quantitative x-ray dark-field computed tomography
    M Bech
    Physik Department, Technische Universitat Munchen, 85748 Garching, Germany
    Phys Med Biol 55:5529-39. 2010
  9. pmc Multiple phytochrome-interacting bHLH transcription factors repress premature seedling photomorphogenesis in darkness
    Pablo Leivar
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Curr Biol 18:1815-23. 2008
    ..in colonizing the land was the evolution of a developmental strategy, termed skotomorphogenesis, whereby postgerminative seedlings emerging from buried seed grow vigorously upward in the subterranean darkness toward the soil surface.
  10. ncbi Resetting central and peripheral circadian oscillators in transgenic rats
    S Yamazaki
    NSF Center for Biological Timing and Department of Biology, University of Virginia, Charlottesville, VA 22903-2477, USA
    Science 288:682-5. 2000
  11. ncbi Darkness induces mobility, and saturation deficit limits questing duration, in the tick Ixodes ricinus
    Jean Luc Perret
    Institute of Zoology, University of Neuchatel, Rue Emile Argand 11, 2007 Neuchatel, Switzerland
    J Exp Biol 206:1809-15. 2003
    ..Almost all locomotor activities of I. ricinus occurred during darkness under either a 14 h:10 h L:D or a 8 h:4 h L:D cycle. We established that all life stages of I...
  12. pmc Regressive evolution in Astyanax cavefish
    William R Jeffery
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Annu Rev Genet 43:25-47. 2009
    A diverse group of animals, including members of most major phyla, have adapted to life in the perpetual darkness of caves. These animals are united by the convergence of two regressive phenotypes, loss of eyes and pigmentation...
  13. ncbi Constitutive expression of the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) gene disrupts circadian rhythms and suppresses its own expression
    Z Y Wang
    Department of Molecular, Cell, and Developmental Biology, UCLA, Los Angeles, California 90095 1606, USA
    Cell 93:1207-17. 1998
    ..Furthermore, the expression of both endogenous CCA1 and the related LHY gene was suppressed. Our results suggest that CCA1 is a part of a feedback loop that is closely associated with the circadian clock in Arabidopsis...
  14. pmc Molecular and photosynthetic responses to prolonged darkness and subsequent acclimation to re-illumination in the diatom Phaeodactylum tricornutum
    Marianne Nymark
    Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway
    PLoS ONE 8:e58722. 2013
    ..When returned to the photic zone after experiencing longer periods in darkness, mechanisms exist that enable the diatoms both to survive sudden light exposure and immediately utilize the ..
  15. ncbi Impacts of drought on leaf respiration in darkness and light in Eucalyptus saligna exposed to industrial-age atmospheric CO₂ and growth temperature
    Gohar Ayub
    Plant Sciences Division, Research School of Biology, Building 46, The Australian National University, Canberra, ACT 0200, Australia
    New Phytol 190:1003-18. 2011
    ..Rates of R in darkness (R(dark) ) and light (R(light) ), photosynthesis (A) and related leaf traits (mass : area relationships, and ..
  16. ncbi Scototaxis as anxiety-like behavior in fish
    Caio Maximino
    Laboratório de Neurociências e Comportamento, Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, Brazil
    Nat Protoc 5:209-16. 2010
    ..When individual animals are exposed to the apparatus on only one occasion, results can be obtained in 20 min per fish...
  17. ncbi Gating of the rapid shade-avoidance response by the circadian clock in plants
    Michael G Salter
    Department of Biology, University of Leicester, Leicester LE1 7RH, UK
    Nature 426:680-3. 2003
    ..4). Furthermore PIL1 and TOC1 are both required for the accelerated growth associated with the shade-avoidance response...
  18. ncbi Seeing better at night: life style, eye design and the optimum strategy of spatial and temporal summation
    E J Warrant
    Institute for Advanced Study, Berlin, Germany
    Vision Res 39:1611-30. 1999
    ..The opposite strategy is predicted for animals which need to see large, fast images. The predictions of the model agree very well with the known visual behaviours of nocturnal animals...
  19. ncbi Constant darkness induces IL-6-dependent depression-like behavior through the NF-κB signaling pathway
    Francisco J Monje
    Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria
    J Neurosci 31:9075-83. 2011
    ..Here we investigate whether long-term light deprivation in the constant darkness (DD) paradigm affects depression-like behavior in mice and concomitantly modulates the levels of proinflammatory ..
  20. ncbi The mPer2 gene encodes a functional component of the mammalian circadian clock
    B Zheng
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 400:169-73. 1999
    ..for this mutation display a shorter circadian period followed by a loss of circadian rhythmicity in constant darkness. The mutation also diminishes the oscillating expression of both mPer1 and mPer2 in the suprachiasmatic nucleus, ..
  21. ncbi Image statistics and the perception of surface qualities
    Isamu Motoyoshi
    Human and Information Science Lab, NTT Communication Science Labs, Nippon Telegraph and Telephone Corporation, 3 1 Morinosato Wakamiya, Atsugi, 243 0198, Japan
    Nature 447:206-9. 2007
    ..We suggest that there are neural mechanisms sensitive to skewed statistics, and that their outputs can be used in estimating surface properties...
  22. ncbi Influence of photoperiod duration and light-dark transitions on entrainment of Per1 and Per2 gene and protein expression in subdivisions of the mouse suprachiasmatic nucleus
    Serhiy Sosniyenko
    Department of Neurohumoral Regulations, Institute of Physiology, v v i, Academy of Sciences of the Czech Republic, Czech Republic
    Eur J Neurosci 30:1802-14. 2009
    ..The data indicate that the twilight photoperiod provides stronger synchronization among the individual SCN cell subpopulations than the rectangular one, and the effect is more pronounced under the short than under the long photoperiod...
  23. ncbi The chlorophyllases AtCLH1 and AtCLH2 are not essential for senescence-related chlorophyll breakdown in Arabidopsis thaliana
    Nicole Schenk
    Institute of Plant Sciences, University of Bern, Altenbergrain 21, CH 3013 Bern, Switzerland
    FEBS Lett 581:5517-25. 2007
    ..From our data we conclude that AtCLHs are not required for senescence-related chlorophyll breakdown in vivo and propose that genuine chlorophyllase has not yet been molecularly identified...
  24. pmc Identification of a novel chloroplast protein AtNYE1 regulating chlorophyll degradation during leaf senescence in Arabidopsis
    Guodong Ren
    State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, China
    Plant Physiol 144:1429-41. 2007
    ..These results collectively indicate that NYE1 plays an important regulatory role in Chl degradation during senescence by modulating pheophorbide a oxygenase activity...
  25. ncbi Nuclear targeted AtS40 modulates senescence associated gene expression in Arabidopsis thaliana during natural development and in darkness
    Isabell Fischer-Kilbienski
    Institute of Botany, University of Kiel, Olshausenstrasse 40, 24098 Kiel, Germany
    Plant Mol Biol 73:379-90. 2010
    ..While in the wildtype expression of AtS40-3 was activated by darkness, in the s40-3a mutant the expression of AtS40-3 stayed at a low level...
  26. ncbi Nodulation enhances dark CO₂ fixation and recycling in the model legume Lotus japonicus
    Mariangela N Fotelli
    Department of Agricultural Biotechnology, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece
    J Exp Bot 62:2959-71. 2011
    ..A potential mechanism is proposed for reducing carbon losses during SNF by the direct reincorporation of CO(2) respired by nodules and the transport and metabolism of C-containing metabolites in hypergeous organs...
  27. ncbi Light experience and the development of behavioural lateralisation in chicks. II. Choice of familiar versus unfamiliar model social partner
    Richard J Andrew
    Centre for Neuroscience and Animal Behaviour, School of Biological, Biomedical and Molecular Sciences, Building W28, University of New England, Armidale, NSW 2351, Australia
    Behav Brain Res 155:67-76. 2004
    ..The effects of exposure are discussed as an example of the generation of a range of behavioural phenotypes, which are sustained within a single population by varying or frequency-dependent selection...
  28. pmc Rapid induction of distinct stress responses after the release of singlet oxygen in Arabidopsis
    Roel G L op den Camp
    Institute of Plant Sciences, Plant Genetics, Swiss Federal Institute of Technology, CH 8092 Zurich, Switzerland
    Plant Cell 15:2320-32. 2003
    ..Its biological activity in Arabidopsis exhibits a high degree of specificity that seems to be derived from the chemical identity of this reactive oxygen species and/or the intracellular location at which it is generated...
  29. ncbi Impaired glycogen synthesis causes metabolic overflow reactions and affects stress responses in the cyanobacterium Synechocystis sp. PCC 6803
    Marianne Gründel
    Humboldt Universitat zu Berlin, Institute of Biology Biochemistry of Plants, Chausseestrasse 117, Berlin, Germany
    Microbiology 158:3032-43. 2012
    ..We first proved the role of glycogen as a respiratory substrate in periods of darkness, the role of glycogen as a reserve to survive starvation periods such as nitrogen depletion and the role of ..
  30. pmc Differences of acute versus chronic ethanol exposure on anxiety-like behavioral responses in zebrafish
    Priya Mathur
    Department of Bioengineering and Therapeutic Sciences, Programs in Biological Sciences and Human Genetics, University of California, San Francisco, CA 94143 2811, United States
    Behav Brain Res 219:234-9. 2011
  31. ncbi Cerebellum shapes hippocampal spatial code
    Christelle Rochefort
    Neurobiologie des Processus Adaptatifs UMR 7102, Navigation, Memory, and Aging ENMVI Team, Université Pierre et Marie Curie Centre National de la Recherche Scientifique CNRS, F 75005 Paris, France
    Science 334:385-9. 2011
    ..Together, these results suggest that cerebellar PKC-dependent mechanisms are involved in processing self-motion signals essential to the shaping of hippocampal spatial representation...
  32. pmc Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formation
    C M Altimus
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 105:19998-20003. 2008
    ..Thus, in addition to their known role in aligning circadian physiology with day and night, ipRGCs also relay light and dark information from both rod-cone and melanopsin-based pathways to modulate sleep and wakefulness...
  33. pmc HY5, Circadian Clock-Associated 1, and a cis-element, DET1 dark response element, mediate DET1 regulation of chlorophyll a/b-binding protein 2 expression
    Bridey B Maxwell
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Plant Physiol 133:1565-77. 2003
    ..We conclude that DET1 represses the CAB2 promoter in the dark by regulating the binding of two factors, CAB2 DET1-associated factor 1 and Circadian Clock-Associated 1, to the DtRE...
  34. pmc Differential coloring reveals that plastids do not form networks for exchanging macromolecules
    Martin H Schattat
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G2W1, Canada
    Plant Cell 24:1465-77. 2012
  35. pmc Light-induced structural and functional plasticity in Drosophila larval visual system
    Quan Yuan
    Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Science 333:1458-62. 2011
  36. ncbi Gibberellins modulate light signaling pathways to prevent Arabidopsis seedling de-etiolation in darkness
    David Alabadi
    Instituto de Biología Molecular y Celular de Plantas CSIC UPV, Av De Los Naranjos s n, 46022 Valencia, Spain
    Plant J 53:324-35. 2008
    ..Seedlings deficient in gibberellin (GA) synthesis or signaling display a de-etiolated phenotype when grown in darkness, equivalent to the phenotype of cop1 mutants, which indicates that the switch between photo- and ..
  37. ncbi High bicarbonate assimilation in the dark by Arctic bacteria
    Laura Alonso-Sáez
    Limnology Department of Ecology and Evolution, Uppsala University, Sweden
    ISME J 4:1581-90. 2010
  38. pmc Molecular analysis of photic inhibition of blood-feeding in Anopheles gambiae
    Suchismita Das
    W, Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615N Wolfe Street, Baltimore, MD 21205 2179, USA
    BMC Physiol 8:23. 2008
  39. pmc An integrative model for phytochrome B mediated photomorphogenesis: from protein dynamics to physiology
    Julia Rausenberger
    Centre for Biological Systems Analysis, University of Freiburg, Freiburg, Germany
    PLoS ONE 5:e10721. 2010
    ..To monitor the intensity and spectral composition of the ambient light environment, plants have evolved multiple photoreceptors, including the red/far-red light-sensing phytochromes...
  40. ncbi Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation
    A Sehgal
    Department of Neuroscience, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Science 270:808-10. 1995
  41. pmc Genetic and molecular analysis of an allelic series of cop1 mutants suggests functional roles for the multiple protein domains
    T W McNellis
    Department of Biology, Yale University, New Haven, Connecticut 06520 8104
    Plant Cell 6:487-500. 1994
    ..1, is an essential regulatory molecule that plays a role in the repression of photomorphogenic development in darkness and in the ability of light-grown plants to respond to photoperiod, end-of-day far-red treatment, and ratio of ..
  42. pmc Gibberellins repress photomorphogenesis in darkness
    David Alabadi
    Instituto de Biologia Molecular y Celular de Plantas, Valencia 46022, Spain
    Plant Physiol 134:1050-7. 2004
    Plants undergo two different developmental programs depending on whether they are growing in darkness (skotomorphogenesis) or in the presence of light (photomorphogenesis)...
  43. ncbi Circadian adaptation to night-shift work by judicious light and darkness exposure
    Diane B Boivin
    Centre for Study and Treatment of Circadian Rhythms, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec H4H 1R3, Canada
    J Biol Rhythms 17:556-67. 2002
    ..On work days, participants maintained regular sleep/wake schedules including a single 8-h sleep/darkness episode beginning 2 h after the end of the night shift...
  44. pmc Light deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats
    M M C Gonzalez
    Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6100, USA
    Proc Natl Acad Sci U S A 105:4898-903. 2008
    ..We recently showed that rats kept for 6 weeks in constant darkness (DD) have anatomical and behavioral features similar to depressed patients, including dysregulation of circadian ..
  45. ncbi Reactivation of ocular dominance plasticity in the adult visual cortex
    Tommaso Pizzorusso
    Scuola Normale Superiore, 56100 Pisa, Italy
    Science 298:1248-51. 2002
    ..The mature ECM is thus inhibitory for experience-dependent plasticity, and degradation of CSPGs reactivates cortical plasticity...
  46. pmc Circadian rhythms confer a higher level of fitness to Arabidopsis plants
    Rachel M Green
    Department of Molecular, Cell and Developmental Biology, P O Box 160606, University of California Los Angeles, Los Angeles, CA 90095 1606, USA
    Plant Physiol 129:576-84. 2002
    ..In addition, we demonstrate that two other circadian rhythm mutants, LHY-ox and elf3, have low-viability phenotypes. Our findings demonstrate the adaptive advantage of circadian rhythms in Arabidopsis...
  47. ncbi The genetic basis of singlet oxygen-induced stress responses of Arabidopsis thaliana
    Daniela Wagner
    Institute of Plant Sciences, Plant Genetics, Swiss Federal Institute of Technology ETH, CH 8092 Zurich, Switzerland
    Science 306:1183-5. 2004
    ..Instead, seedling lethality and growth inhibition of mature plants result from genetic programs that are activated after the release of singlet oxygen has been perceived by the plant...
  48. pmc Patterns of expression and normalized levels of the five Arabidopsis phytochromes
    Robert A Sharrock
    Department of Plant Sciences and Plant Pathology, 119 ABS Building, Montana State University, Bozeman, Montana 59717 3140, USA
    Plant Physiol 130:442-56. 2002
    ..These studies indicate that, with the exception of phytochrome A, the family of phytochrome photoreceptors in Arabidopsis constitutes a quite stable and very broadly distributed array of sensory molecules...
  49. ncbi The sunflower HD-Zip transcription factor HAHB4 is up-regulated in darkness, reducing the transcription of photosynthesis-related genes
    Pablo A Manavella
    Cátedra de Biología Celular y Molecular, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, CONICET, CC 242 Ciudad Universitaria, 3000, Santa Fe, Argentina
    J Exp Bot 59:3143-55. 2008
    ..In this study it is shown that the expression of HAHB4 is induced in darkness and quickly disappears when plants are exposed to light...
  50. ncbi Interaction of the response regulator ARR4 with phytochrome B in modulating red light signaling
    U Sweere
    Institut für Biologie II Botanik, Universitat Freiburg, Schanzlestrasse 1, 79104 Freiburg, Germany
    Science 294:1108-11. 2001
    ..We propose that the response regulator 4 acts as an output element of a two-component system that modulates red light signaling on the level of the phytochrome B photoreceptor...
  51. pmc The Arabidopsis mutant alh1 illustrates a cross talk between ethylene and auxin
    Filip Vandenbussche
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, KL Ledeganckstraat 35, B 9000 Ghent, Belgium
    Plant Physiol 131:1228-38. 2003
    ..Together, these data indicate that alh1 is altered in the cross talk between ethylene and auxins, probably at the level of auxin transport...
  52. ncbi The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness
    Dun Xian Tan
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Biol Rev Camb Philos Soc 85:607-23. 2010
    ..These functions likely include the chemical expression of darkness in vertebrates, environmental tolerance in fungi and plants, sexual signaling in birds and fish, seasonal ..
  53. pmc ATP consumption by mammalian rod photoreceptors in darkness and in light
    Haruhisa Okawa
    Neuroscience Graduate Program, Zilkha Neurogenetic Institute, USC Keck School of Medicine, Los Angeles, CA 90089, USA
    Curr Biol 18:1917-21. 2008
    ..In darkness, rods consume 10(8) ATP s(-1), about the same as Drosophila photoreceptors...
  54. ncbi The F-box protein slimb controls the levels of clock proteins period and timeless
    Brigitte Grima
    Institut de Neurobiologie Alfred Fessard NGI, CNRS UPR 2216, Centre National de la Recherche Scientifique, av de la Terrasse, 91198 Gif sur Yvette, France
    Nature 420:178-82. 2002
    ..In constant darkness, highly phosphorylated forms of the Per and Tim proteins are constitutively present in the mutants, indicating ..
  55. ncbi A transcription factor response element for gene expression during circadian night
    Hiroki R Ueda
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Company, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Nature 418:534-9. 2002
    ..We profiled suprachiasmatic nuclei and liver genome-wide expression patterns under light/dark cycles and constant darkness. We determined transcription start sites of human orthologues for newly identified cycling genes and then ..
  56. ncbi Photic resetting in night-shift work: impact on nurses' sleep
    Diane B Boivin
    Centre for Study and Treatment of Circadian Rhythms, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Chronobiol Int 29:619-28. 2012
    ..All workers maintained stable 8-h daytime sleep/darkness schedules. The authors found that workers of the treatment group had daytime sleep episodes that lasted 7.1 ± ...
  57. pmc Overexpression of Arabidopsis acyl-CoA binding protein ACBP3 promotes starvation-induced and age-dependent leaf senescence
    Shi Xiao
    School of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong, China
    Plant Cell 22:1463-82. 2010
    ..Accelerated senescence in ACBP3-OEs is dependent on salicylic acid but not jasmonic acid signaling...
  58. ncbi Directionally selective calcium signals in dendrites of starburst amacrine cells
    Thomas Euler
    Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Nature 418:845-52. 2002
    ..This demonstrates that direction selectivity is computed locally in dendritic branches at a stage before ganglion cells...
  59. ncbi Wavelength-dependent effects of evening light exposure on sleep architecture and sleep EEG power density in men
    Mirjam Munch
    Centre for Chronobiology, Psychiatric Univ Clinics, University of Basel, Switzerland
    Am J Physiol Regul Integr Comp Physiol 290:R1421-8. 2006
    ..Our results can be interpreted in terms of an induction of a circadian phase delay and/or repercussions of a stronger alerting effect after blue light, persisting into the sleep episode...
  60. ncbi A daily palatable meal without food deprivation entrains the suprachiasmatic nucleus of rats
    Jorge Mendoza
    Departamento de Anatomia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico DF, 04510, Mexico
    Eur J Neurosci 22:2855-62. 2005
    ..Rats fed ad libitum, in constant darkness, received a palatable meal for 6 weeks starting in the middle of the subjective day...
  61. pmc Strigolactones negatively regulate mesocotyl elongation in rice during germination and growth in darkness
    Zhongyuan Hu
    Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo, Tokyo, 113 8657 Japan
    Plant Cell Physiol 51:1136-42. 2010
    ..We observed that mesocotyl elongation in darkness was greater in rice mutants defective in these genes than in the wild type...
  62. ncbi Light deprivation induces depression-like behavior and suppresses neurogenesis in diurnal mongolian gerbil (Meriones unguiculatus)
    Benson Wui Man Lau
    Department of Anatomy, The State Key Laboratory of Brain and Cognitive Sciences, Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Pokfulam, Hong Kong SAR, PR China
    Cell Transplant 20:871-81. 2011
    ..Additionally, the current experiment may offer a model for exploring the relationship among daylight exposure, circadian cycles, depressive behavior, and the underlying mechanisms...
  63. ncbi The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila
    R Stanewsky
    Department of Biology and National Science Foundation Center for Biological Timing, Brandeis University, Waltham, Massachusetts 02454, USA
    Cell 95:681-92. 1998
    ..Levels of period or timeless clock gene products in the mutant are flat in daily light-dark cycles or constant darkness (although PER and TIM oscillate normally in temperature cycles)...
  64. ncbi Effects of threat of shock, shock electrode placement and darkness on startle
    C Grillon
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Int J Psychophysiol 28:223-31. 1998
    ..by an explicit threat cue signalling a period of shock anticipation and by two types of contextual stimuli; darkness and attaching the shock electrodes...
  65. ncbi Phototherapy and orange-tinted goggles for night-shift adaptation of police officers on patrol
    Diane B Boivin
    Centre for Study and Treatment of Circadian Rhythms, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Chronobiol Int 29:629-40. 2012
    ..to wide-spectrum bright light at night, orange-tinted goggles at sunrise, and maintenance of a regular sleep/darkness episode in the day...
  66. ncbi Light signalling mediated by phytochrome plays an important role in cold-induced gene expression through the C-repeat/dehydration responsive element (C/DRE) in Arabidopsis thaliana
    Hyoun Joung Kim
    Kumho Life and Environmental Science Laboratory, Puk Gu, Gwang Ju, Korea
    Plant J 29:693-704. 2002
  67. ncbi Melatonin, hormone of darkness and more: occurrence, control mechanisms, actions and bioactive metabolites
    R Hardeland
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gottingen, Gottingen, Germany
    Cell Mol Life Sci 65:2001-18. 2008
    ..Moreover, melatonin is a source of bioactive metabolites, such as 5-methoxytryptamine, N(1)-acetyl-N(2)-formyl-5-methoxykynuramine and N(1)-acetyl-5-methoxykynuramine...
  68. ncbi A critical role for ureides in dark and senescence-induced purine remobilization is unmasked in the Atxdh1 Arabidopsis mutant
    Galina Brychkova
    The Jacob Blaustein Institutes for Desert Research, The Albert Katz Department of Dryland Biotechnologies, Ben Gurion University, PO Box 653, Beer Sheva 84105, Israel
    Plant J 54:496-509. 2008
    ..We observed that in wild-type plants conditions of extended darkness or increasing leaf age caused induction of transcripts related to purine catabolism, resulting in marked ..
  69. pmc Circadian phase-dependent modulation of cGMP-gated channels of cone photoreceptors by dopamine and D2 agonist
    Gladys Y P Ko
    Department of Biology and Biochemistry and Biological Clocks Program, University of Houston, Houston, Texas 77204 5001, USA
    J Neurosci 23:3145-53. 2003
    ..from cultured chick cones were performed at circadian time (CT) 4-7 and CT 16-19 on the second day of constant darkness. Exposing intact cells to DA or the D2 agonist quinpirole for 2 hr before patch excision caused a significant ..
  70. pmc High-level production of the industrial product lycopene by the photosynthetic bacterium Rhodospirillum rubrum
    Guo shu Wang
    Department of Bioenergetics, Institute of Biology, University of Stuttgart, Stuttgart, Germany
    Appl Environ Microbiol 78:7205-15. 2012
    ..This study provides the first genetic proof that the R. rubrum CrtI produces lycopene exclusively as an end product...
  71. pmc Night-time neuronal activation of Cluster N in a day- and night-migrating songbird
    Manuela Zapka
    AG Neurosensorik, Institut für Biologie und Umweltwissenschaften, University of Oldenburg, D 26111 Oldenburg, Germany
    Eur J Neurosci 32:619-24. 2010
  72. ncbi Darkness reduces BDNF expression in the visual cortex and induces repressive chromatin remodeling at the BDNF gene in both hippocampus and visual cortex
    Nina N Karpova
    Sigrid Jusélius Laboratory, Neuroscience Center, University of Helsinki, Helsinki, Finland
    Cell Mol Neurobiol 30:1117-23. 2010
    Neuronal activity regulates the expression of brain-derived neurotrophic factor (BDNF) in brain. In darkness, reduced neuronal activity in the visual cortex markedly decreases total BDNF transcription level in adult rats...
  73. ncbi It is darkness and not light: Depression-like behaviors of diurnal unstriped Nile grass rats maintained under a short photoperiod schedule
    Tal Ashkenazy-Frolinger
    Department of Zoology, Tel Aviv University, Tel Aviv, Israel
    J Neurosci Methods 186:165-70. 2010
  74. ncbi Differential effects of eyes open or closed in darkness on brain activation patterns in blind subjects
    K Hufner
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, 81377 Munich, Germany
    Neurosci Lett 466:30-4. 2009
    ..specific task conditions can be compared to a reference condition which is often eyes-open or eyes-closed in darkness without the execution of a specific task...
  75. ncbi Role of melanopsin in circadian responses to light
    Norman F Ruby
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Science 298:2211-3. 2002
    ..Although melanopsin is not essential for the circadian clock to receive photic input, it contributes significantly to the magnitude of photic responses...
  76. ncbi Alterations in serum melatonin and sleep in individuals in a sub-arctic region from winter to spring
    Trond Bratlid
    Psychiatric Department, University of Tromsø, Norway
    Int J Circumpolar Health 62:242-54. 2003
  77. ncbi Dark rearing alters the development of GABAergic transmission in visual cortex
    Bernardo Morales
    Mind Brain Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 22:8084-90. 2002
    ..Thus, sensory experience appears to play a permissive role in the maturation of intracortical GABAergic circuits...
  78. ncbi Directional control of hippocampal place fields
    K J Jeffery
    Department of Anatomy and Developmental Biology, University College London, UK
    Exp Brain Res 117:131-42. 1997
    ..When room cues were present, distal visual cues predominated over internal cues in establishing place field orientation...
  79. ncbi Light during darkness and cancer: relationships in circadian photoreception and tumor biology
    Samar A Jasser
    Department of Neurology, Light Research Program, Thomas Jefferson University, 1025 Walnut Street, Suite 507, Philadelphia, PA 19107, USA
    Cancer Causes Control 17:515-23. 2006
    ..Continued rigorous empirical inquiry into the physiology and clinical implications of these habitual, integrated aspects of life is highly warranted at this time...
  80. pmc Response of the human circadian system to millisecond flashes of light
    Jamie M Zeitzer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, United States of America
    PLoS ONE 6:e22078. 2011
    ..These data are consistent with the hypothesis that the circadian system can temporally integrate extraordinarily brief light exposures...
  81. ncbi Expression of the circadian clock-related gene pex in cyanobacteria increases in darkness and is required to delay the clock
    Naoki Takai
    International Graduate School of Arts and Sciences, Yokohama City University, Seto 22 2, Yokohama 236 0027, Japan
    J Biol Rhythms 21:235-44. 2006
    ..Levels of pex mRNA increased significantly in a 12-h exposure to darkness. Western blotting with a GST-Pex antibody revealed a 13...
  82. ncbi Maltose is the major form of carbon exported from the chloroplast at night
    Sean E Weise
    Department of Botany, University of Wisconsin Madison, 430 Lincoln Drive, Madison, WI 53706 USA
    Planta 218:474-82. 2004
    ..we determined that maltose was distributed equally between the chloroplast and cytosolic fractions during darkness. In the light there was approximately 24% more maltose in the cytosol than the chloroplast...
  83. pmc Arabidopsis nitric oxide synthase1 is targeted to mitochondria and protects against oxidative damage and dark-induced senescence
    Fang Qing Guo
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, 92093 0116, USA
    Plant Cell 17:3436-50. 2005
    ..These results demonstrate that NOS1 is a mitochondrial NOS that reduces ROS levels, mitigates oxidative damage, and acts as an antisenescence agent...
  84. ncbi Entrainment of the rat motor activity rhythm: effects of the light-dark cycle and physical exercise
    T Cambras
    Departament de Fisiologia, Divisió IV, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Physiol Behav 70:227-32. 2000
    ..Rats were maintained first under LD cycles and afterwards under constant darkness (DD). Motor activity was recorded throughout the whole experiment by means of activity meters with infrared beams...
  85. pmc Evidence from opsin genes rejects nocturnality in ancestral primates
    Ying Tan
    Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 102:14712-6. 2005
    ..This view is further supported by the distribution pattern of the middle-wavelength (M) and long-wavelength (L) opsin genes among prosimians...
  86. ncbi Effects of anxiolytics in zebrafish: similarities and differences between benzodiazepines, buspirone and ethanol
    Daiane L Gebauer
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900 Porto Alegre, RS, Brazil
    Pharmacol Biochem Behav 99:480-6. 2011
    ..Height in the tank and shoal cohesion seem to be useful behavioral parameters in discriminating different classes of these drugs...
  87. pmc Genome-wide dynamic transcriptional profiling of the light-to-dark transition in Synechocystis sp. strain PCC 6803
    Ryan T Gill
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Bacteriol 184:3671-81. 2002
  88. pmc Transient release of oxygenated volatile organic compounds during light-dark transitions in Grey poplar leaves
    Martin Graus
    Institut fur Ionenphysik, Leopold Franzens Universitat Innsbruck, A 6020 Innsbruck, Austria
    Plant Physiol 135:1967-75. 2004
  89. pmc Biological clock in total darkness: the Clock/MOP3 circadian system of the blind subterranean mole rat
    A Avivi
    Institute of Evolution, University of Haifa, Mount Carmel, Haifa 31905, Israel
    Proc Natl Acad Sci U S A 98:13751-6. 2001
    ..Understanding Clock/MOP3 function could highlight circadian mechanisms in blind mammals and their unique pattern as a result of adapting to life underground...
  90. pmc Flow of energy in the outer retina in darkness and in light
    Jonathan D Linton
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:8599-604. 2010
    ..energy flows from these central mitochondria as phosphocreatine toward the photoreceptor's synaptic terminal in darkness. In light, it flows in the opposite direction as ATP toward the outer segment...
  91. pmc Visual deprivation decreases somatic GAD65 puncta number on layer 2/3 pyramidal neurons in mouse visual cortex
    Alicja Kreczko
    Department of Biology, University of Maryland, College Park, 20742, USA
    Neural Plast 2009:415135. 2009
    ..There was no change in GAD65-puncta volume or intensity. These results support the reorganization of inhibitory circuitry within layer 2/3 of visual cortex in response to changes in visual experience...
  92. pmc Persistence of experience-induced homeostatic synaptic plasticity through adulthood in superficial layers of mouse visual cortex
    Anubhuthi Goel
    Department of Biology, College of Chemical and Life Sciences, University of Maryland, College Park, Maryland 20742, USA
    J Neurosci 27:6692-700. 2007
    ..Our results demonstrate that the superficial layers of adult mouse visual cortex retain the ability to undergo reversible experience-dependent homeostatic synaptic plasticity...
  93. pmc The basic helix-loop-helix transcription factor PIF5 acts on ethylene biosynthesis and phytochrome signaling by distinct mechanisms
    Rajnish Khanna
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Plant Cell 19:3915-29. 2007
    ..data thus indicate that overexpressed PIF5 causes altered ethylene levels, which promote the triple response in darkness, whereas in the light, the interaction of photoactivated phyB with PIF5 causes degradation of the photoreceptor ..
  94. pmc Isolation and characterization of rice phytochrome A mutants
    M Takano
    Department of Plant Physiology, National Institute of Agrobiological Resources, Tsukuba, Ibaraki 305 8602, Japan
    Plant Cell 13:521-34. 2001
  95. ncbi Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting
    Satchidananda Panda
    Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
    Science 298:2213-6. 2002
    ..entrain to a light/dark cycle and do not exhibit any overt defect in circadian activity rhythms under constant darkness. However, they display severely attenuated phase resetting in response to brief pulses of monochromatic light, ..
  96. ncbi A comparison of the expression patterns of several senescence-associated genes in response to stress and hormone treatment
    L M Weaver
    Dept of Biochemistry, University of Wisconsin at Madison, 53706, USA
    Plant Mol Biol 37:455-69. 1998
    ..genes (SAGs) in attached and/or detached leaves was compared in response to age, dehydration, darkness, abscisic acid, cytokinin, and ethylene treatments...
  97. ncbi Light-regulated subcellular translocation of Drosophila TRPL channels induces long-term adaptation and modifies the light-induced current
    Monika Bähner
    Zoological Institute, Department of Cell and Neurobiology, University of Karlsruhe, 76128 Karlsruhe, Germany
    Neuron 34:83-93. 2002
    ..background lights, and they respond to a wider range of light intensities, which fit them to function better in darkness or dim background illumination...
  98. ncbi Comparative study on nocturnal behavior of Aedes aegypti and Aedes albopictus
    Hitoshi Kawada
    Department of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Nagasaki 852 8523, Japan
    J Med Entomol 42:312-8. 2005
    ..01 foot candle) in Ae. aegypti and >10 lx (approximately 1 foot candle) in Ae. albopictus. Complete darkness during the daytime deactivated the host-seeking activity of both species, irrespective of their increasing flight ..
  99. ncbi Light and darkness regulate melanopsin in the retinal ganglion cells of the albino Wistar rat
    Jens Hannibal
    Department of Clinical Biochemistry, Bispebjerg Hospital, University of Copenhagen, DK 2400 Copenhagen NV, Denmark
    J Mol Neurosci 27:147-55. 2005
    ..of melanopsin at the mRNA and protein level during a day/night cycle and during prolonged periods of light and darkness in the retina of albino Wistar rats...
  100. ncbi Visual deprivation alters development of synaptic function in inner retina after eye opening
    N Tian
    Department of Ophthalmology, UCSF School of Medicine, San Francisco, CA 94143, USA
    Neuron 32:439-49. 2001
    ..These findings indicate there is a degree of activity-dependent plasticity in the mammalian retina that has not been previously described...
  101. ncbi Rice tillering dwarf mutant dwarf3 has increased leaf longevity during darkness-induced senescence or hydrogen peroxide-induced cell death
    Haifang Yan
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Tokyo, Japan
    Genes Genet Syst 82:361-6. 2007
    Senescence or cell death in plant leaves is known to be inducible by darkness or H(2)O(2). When the Arabidopsis gene MAX2/ORE9 is disrupted, leaf senescence or cell death in response to the above stimuli is delayed...

Research Grants64

  1. Circadian Expression of Procolipase in the Liver: A Metabolic Signal
    Mark E Lowe; Fiscal Year: 2010
    ..lipase related protein 2 (PLRP2) expression in the liver and other tissues when mice are kept in constant darkness raises the possibility that these proteins contribute to the regulation of feeding behavior and lipid metabolism ..
  2. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
    ..occurs in common environmental niches (pigeon guano, plants/trees) and in response to nutrient limitation, light/darkness, carbon dioxide, and inositol;2) elucidated same-sex genetic cascades involving the novel cell surface receptor ..
  3. Circadian Clock Function in the Mammalian Retina
    Christophe P Ribelayga; Fiscal Year: 2013
    ..The primary hallmark of clocks is that they continue to run in constant environmental conditions (e.g., total darkness) with periods of approximately 24 h (circadian clocks), and are synchronized to environmental rhythms through ..
    Thomas T Norton; Fiscal Year: 2012
    ..Specific Aim 3 will use an "association" paradigm in which three different methods (darkness, form deprivation, and minus-lens wear) will be used to induce myopia to identify the pattern of retinal gene ..
  5. TRP channel expression and function in ON-bipolar cells
    Robert M Duvoisin; Fiscal Year: 2012
    ..synapse, the tonic release of glutamate from photoreceptor terminals maintains a high synaptic concentration in darkness that decreases in response to light...
  6. Human circadian sensitivity to very short light pulses
    Elizabeth B Klerman; Fiscal Year: 2010
    ..We also will investigate the duration of darkness exposure required to reset circadian sensitivity...
  7. Fast-Switching, High-Contrast, Electrochromic Sunwear for Persons with Age-Relate
    ..Controller based on microprocessor, photocell-input, placed on glasses or behind ear, to automatically control darkness/color...
  8. Manganese-Enhanced MRI Studies of Vision Loss with Aging
    DAVID PHILIP BISSIG; Fiscal Year: 2013
    ..patch one eye and measure retinal and brain Mn2+ uptake in response to visual stimulation (unpatched eye) and darkness (patched eye) with MEMRI...
  9. Circadian Modulation of Drug-Seeking Behavior
    Heiko T Jansen; Fiscal Year: 2011
    ..CPP Aims 1 and 2 will use sham and SCN-lesioned rats and test cocaine extinction and reinstatement under constant darkness to define the role of the SCN and extra-SCN brain regions on time-of-day variation in cocaine-seeking behavior...
  10. Bias in auditory spatiotemporal receptive fields: computational and functional im
    Yunyan Wang; Fiscal Year: 2013
    ..Barn owls hunt successfully in total darkness using only auditory cues...
  11. Building foundations for a neurobiology of fatigue: validating an animal model
    Mary E Harrington; Fiscal Year: 2013
    ..with pro-inflammatory cytokines will lead to circadian disruption measured in mice housed under constant darkness, interacting with the age and gender of the animal...
  12. Human circadian, sleep, cardiovascular and neurobehavioral responses to light
    Elizabeth B Klerman; Fiscal Year: 2013
    ..Experimentally, we will document the effects of short duration light stimuli and the duration of darkness exposure required to reset circadian sensitivity...
  13. The Molecular Mechanism of PDF Signaling to the Drosophila Circadian Clock
    ADAM C SELUZICKI; Fiscal Year: 2011
    ..These rhythms are entrained by and synchronize to environmental light cycles but are also maintained in constant darkness, demonstrating the function of a biological clock...
  14. Role of Photoreceptors in the Pathogenesis of Diabetic Retinopathy
    Timothy S Kern; Fiscal Year: 2013
    ..predict that oxidative and inflammatory effects on the retinal vasculature in diabetes will be exacerbated by darkness, and can be inhibited with light...
  15. Light-dependent Transducin Movement in Retinal Rods.
    Vladlen Z Slepak; Fiscal Year: 2013
    ..In darkness, transducin concentrates in the outer segments (OS) of rods...
  16. Circadian Clock Regulation of the Mammalian Retina
    Charles J Weitz; Fiscal Year: 2010
    ..if circadian clock function within the retina influences the function of the SCN circadian clock in constant darkness. Deeper general understanding of the mammalian circadian system will likely have important implications for human ..
  17. Signaling mechanisms of retinal bipolar cells
    Catherine W Morgans; Fiscal Year: 2012
    ..synapse, the tonic release of glutamate from photoreceptor terminals maintains a high synaptic concentration in darkness that rapidly decreases in response to light...
  18. Control of Photoreceptor Metabolism
    JAMES BRYANT HURLEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Metabolic demands of photoreceptors in darkness are qualitatively different than in light. In darkness their metabolism is like that of conventiona neurons...
  19. Pharmaceutical Therapy for Seasonal Affective Disorder
    Jay K Trautman; Fiscal Year: 2010
    ..SAD exhibit classical symptoms of depression during the winter months, associated with the prolonged periods of darkness as are found in higher latitudes...
  20. Neuronal and genetic basis of photosensory behavior in C. elegans
    X Z Shawn Xu; Fiscal Year: 2013
    ..However, C. elegans were believed to lack the sense of light, as they live in darkness (soil) and also do not have eyes...
    Stuart C Mangel; Fiscal Year: 2012
    ..g. constant darkness)...
    Xing Wang Deng; Fiscal Year: 2013
    ..that those three complexes act within nucleus to suppress the photomorphogenic developmental pathway in darkness and light reverses this repressive action, in part by depleting COP1 nuclear accumulation...
  23. Biophysical and neurogenetic analyses of photosensory behavior in Drosophila
    Elizabeth A Kane; Fiscal Year: 2012
    ..Larvae exhibit a strong navigational preference for darkness, but little is known about how the larva utilizes photosensory information to systematically pattern its own ..
    Bernard Cohen; Fiscal Year: 2009
    ..of the body, head and eyes can be characterized and it will be possible to determine the effects of lesions of the vestibular apparatus on natural straight and circular locomotion of monkeys running in light and darkness.
  25. Analysis of a new circadian mutant
    Michael Menaker; Fiscal Year: 2013
    ..and will explore the responses of wild type, heterozygous and homozygous littermates of both sexes to constant darkness, constant light, single light pulses, photoperiods with different light/dark ratis and entraining cycles with ..
  26. Vestibular Reflexes
    WILLIAM MICHAEL KING; Fiscal Year: 2010
    ..Even fully compensated patients may lose their balance and fall in darkness or if exposed to uneven surfaces...
  27. Neural mechanisms for sensory prediction in a cerebellum-like structure
    Tim Requarth; Fiscal Year: 2013
    ..Detecting changes in the field induced by nearby objects allows the fish to navigate and find prey in darkness. However, because the electric organ is in the tail and electroreceptors are located on the head and trunk, the ..
    JAMES BRYANT HURLEY; Fiscal Year: 2013
    ..the mechanisms by which these neurons respond to the changing temporal and spatial energy demands of darkness and light...
    VLADIMIR JIVKOV KEFALOV; Fiscal Year: 2010
    ..via recoverin is a component of the calcium feedback in mouse cones and modulates their phototransduction in darkness and during light adaptation...
  30. Phototransduction and Signaling in Photoreceptors
    King Wai Yau; Fiscal Year: 2013
    ..is the solving of a protracted puzzle/controversy about the spontaneous activity of rod and cone holopigments in darkness, by showing that it indeed arises from a canonical isomerization of the pigment, except being driven by thermal ..
  31. Roles for Granule Cells in Adaptive Processing in a Cerebellum-like Circuit
    NATHANIEL SAWTELL; Fiscal Year: 2013
    ..This electrosense allows them to avoid predators and find prey in darkness. However, these fish also generate electrical fields of their own...
    Scott Nawy; Fiscal Year: 2013
    ..The synapse is sign-inverting because glutamate, released in darkness by rod and cone photoreceptors, hyperpolarizes the membrane of ON bipolar cells...
  33. Volker Hall Animal Facility Phase IV
    SAMUEL CORBIN CARTNER; Fiscal Year: 2010
    ..state of the art animal necropsy room, (2) three animal housing rooms with special light control features (total darkness and/or light), (3) heating ventilation and air conditioning (HVAC) improvement to 16 animal housing rooms ..
  34. Light regulated vascular development of the eye
    Richard A Lang; Fiscal Year: 2013
    ..Also, surprisingly, the maximal effect of dark rearing is found in pups raised in darkness from E16...
  35. Investigating circadian communication within the brain and body
    JENNIFER ANNE EVANS; Fiscal Year: 2012
    ..In preliminary studies, I have used an ultra long photoperiod (20h light: 4h darkness, LD 20:4) to reorganize the SCN into dorsal and ventral regions that express dissociated rhythms on the first ..
  36. Circadian and Aminergic Regulation of Orexin Neurons
    THOMAS SCAMMELL; Fiscal Year: 2005
    ..mediates circadian influences on sleep/wake architecture by studying rodents in a light/dark cycle or in constant darkness; these experiments will use two models of orexin deficiency: orexin knockout mice and transgenic rats with an ..
  37. Retinal Circadian Signaling in a Transgenic Model
    Allan Wiechmann; Fiscal Year: 2004
    ..In the retina, melatonin acts as a paracrine signal of darkness by activating specific receptors that ultimately leads to increased sensitivity to light...
    David Blask; Fiscal Year: 2004
    The long-term goal of this research is to determine if light, present during darkness, is a risk factor for breast cancer progression...
    PAUL LUDDEN; Fiscal Year: 2003
    ..enzyme in Rhodospirillum rubrum is inactivated by ADP{-ribosylation of arg101 in response to ammonium or darkness. DRAT is the ADP-ribosyltransferase responsible for inactivation and DRAG is the glycohydrolase that activates ..
  40. Egress Assistance for Visually Impaired - EVAC Passage
    DANIEL E KISER; Fiscal Year: 2011
    ..sighted (or partially sighted) individuals will be able to see the illumination lettering through the smoke or darkness. During Phase I, Evacus Technologies will perform EVAC Passage assimilation, Access Point Tracking System ..
  41. The Roles of Neuropeptide S System in the Regulation of Sleep and Wakefulness
    Yanling Xu; Fiscal Year: 2007
    ..NPS peptide, NPS precursor and receptor mRNA contents at different circadian times and in conditions of constant darkness and after sleep deprivation...
    ROBERT UFFEN; Fiscal Year: 1980
    Rhodospirillum rubrum grows anaerobically in light, or fermentatively in darkness with pyruvate. Fermenting cells resemble light-grown R. rubrum by containing "chromatophores"...
    Alfred Lewy; Fiscal Year: 2000
    ..adapted from investigator's abstract): Melatonin is a hormone produced by the pineal gland only during nighttime darkness. It acts like a dark signal and therefore resets the body clock, especially if administered during the day...
    Gianluca Tosini; Fiscal Year: 2003
    ..the raphe nuclei, appear in large numbers in the SCN of hamsters that have been held for 16-20 weeks in constant darkness. Our second aim is to explore this observation further by testing two hypotheses: 1) that the effect is caused ..
    Ronald Brown; Fiscal Year: 1999
    ..The gain of the phototransduction cascade is set by the ambient light level. In darkness, a retinal rod can detect a single photon of light, but its dynamic range is limited...
    JUAN SAEZ; Fiscal Year: 1992
    ..of environmental factors including normal innervation, light/dark cycles, constant illumination, and constant darkness. Using immunological techniques and Northern blot analysis we found that rat pineals express both connexins 43 ..
    SANFORD OSTROY; Fiscal Year: 1990
    ..A second area of study is the metabolic effects of typical physiological condtions such as darkness, various levels of illunination, and concentrations of metabolic substrates (such as glucose) or effectors (such ..
    RICHARD LOLLEY; Fiscal Year: 1993
    ..The 33K (33 kilodalton) protein which is phosphorylated in darkness and dephosphorylated during illumination forms a complex with the beta- gamma subunits of transducin...
    Joelle Mast; Fiscal Year: 1992
    ..the usual NICU environment), (ii) continuous but reduced lighting, (iii) diurnally-cycled bright lighting and darkness, (iv) diurnally-cycled reduced lighting and darkness...
    Nam Hai Chua; Fiscal Year: 2007
    ..Interaction domains will be mapped by in vitro pull-down assays. Factor association in vivo in response to darkness and FR will be determined by co-immunoprecipitation and the physiological impact on phyA responses will be ..
    Glenna Dowling; Fiscal Year: 2001
    ..light exposure and exogenous administration of melatonin (a neurohormone produced by the pineal gland during darkness) are needed...
  52. Retinal Gene Expression in Light and Darkness
    Charles Weitz; Fiscal Year: 2003
    ..there is as yet no comprehensive view of retinal gene expression in a natural light-dark cycle or in constant darkness. Microarray technology, developed for massively parallel analysis of gene expression, now permits detailed ..
  53. Subcortical Visual System Development
    JENNIFER PRICHARD; Fiscal Year: 2003
    Exposure to atypical lighting conditions, like chronic darkness, during a critical period in development causes long-lasting deficits in the anatomy and function of the image forming visual system...
  54. Neurobiology of Circadian Dysrhythmias
    WILLIAM SCHWARTZ; Fiscal Year: 2007
    ..that bi-stability in the hamster circadian system is revealed in split hamsters that are transferred from LL to darkness, a condition in which the normally favored unsplit state becomes less robust and more vulnerable to being ..
  55. The role of nyctalopin in the mammalian retina
    CATHERINE MORGANS; Fiscal Year: 2006
    ..Photoreceptors release the neurotransmitter, glutamate, in darkness, and reduce the rate of release in response to light...
  56. Preterm Infants: Light Effects on Health and Development
    Debra Brandon; Fiscal Year: 2007
    ..Recently, cycled light has shown short-term benefits over near darkness, but it is unclear at what gestational age cycled light should be initiated and whether these benefits continue ..
    Mitchell Tyler; Fiscal Year: 2001
    ..circuitry will be built and tested with vestibular intact and vestibular deprived persons, in light and in darkness on a force plate, to measure sway and other stance characteristics...
    GEORGE MOWER; Fiscal Year: 1991
    ..Specifically, rearing in total darkness prolongs the critical period in cats well beyond the normal age limits...
    DWIGHT NELSON; Fiscal Year: 2004
    ..two commonly used assays of circadian photic responsiveness (measured on circadian cycles 1 and 7 of constant darkness). Importantly this comparison will include both wild type as well as mPer2 mutant mice...
    William Widger; Fiscal Year: 1993
    ..Light controls the growth and replication of this bacterium, in darkness it will down regulate photosynthetic pathways by diminishing transcripts of these genes...
    Felix Strumwasser; Fiscal Year: 1990
    ..action potentials (CAPs) which are propagated into the optic nerve, while isolated in vitro and in continuous darkness. The frequency of these CAPs varies with time of day; the rhythm of CAP frequency is robust and persists from 1-2 ..
    Abel Bult Ito; Fiscal Year: 2000
    ..rhythm parameters of wheel-running activity and phase-delay responses to 15-min light pulses in constant darkness. Therefore, these lines represent a unique opportunity to investigate the functional role of AVP and Ca2+-..
    Cheng Lee; Fiscal Year: 2001
    ..Circadian expression in the SCN continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of m-rigui expression in the SCN...
    PAUL LIEBMAN; Fiscal Year: 2002
    ..The equally essential property or molecular stabilization against spontaneous activity in darkness via molecular kinetic energy barriers forms our principal focus in this grant period...