light

Summary

Summary: That portion of the electromagnetic spectrum to which the human eye is sensitive. Light is about 400 to 800 nanometers in wavelength, i.e., between the ultraviolet and infrared spectra.

Top Publications

  1. ncbi Imaging intracellular fluorescent proteins at nanometer resolution
    Eric Betzig
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA
    Science 313:1642-5. 2006
  2. ncbi The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism
    E Virginia Armbrust
    School of Oceanography, University of Washington, Seattle, WA 98195, USA
    Science 306:79-86. 2004
  3. pmc Ultra-high resolution imaging by fluorescence photoactivation localization microscopy
    Samuel T Hess
    Department of Physics and Astronomy, University of Maine, Orono, ME 04469, USA
    Biophys J 91:4258-72. 2006
  4. pmc Channelrhodopsin-2, a directly light-gated cation-selective membrane channel
    Georg Nagel
    Max Planck Institut fur Biophysik, Marie Curie Strasse 15, 60439 Frankfurt, Germany
    Proc Natl Acad Sci U S A 100:13940-5. 2003
  5. pmc Evidence for a SAL1-PAP chloroplast retrograde pathway that functions in drought and high light signaling in Arabidopsis
    Gonzalo M Estavillo
    Australian Research Council Centre of Excellence in Plant Energy Biology, Research School of Biology, Australian National University Canberra, Acton, Australian Capital Territory 0200, Australia
    Plant Cell 23:3992-4012. 2011
  6. ncbi Far-field optical nanoscopy
    Stefan W Hell
    Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, 37070 Gottingen, and German Cancer Research Center DKFZ, High Resolution Optical Microscopy Division, 69120 Heidelberg, Germany
    Science 316:1153-8. 2007
  7. ncbi Multimodal fast optical interrogation of neural circuitry
    Feng Zhang
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 446:633-9. 2007
  8. pmc Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity
    S Hattar
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Science 295:1065-70. 2002
  9. ncbi VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism
    Özgür Bayram
    Institute of Microbiology and Genetics, Georg August University, D 37077 Gottingen, Germany
    Science 320:1504-6. 2008
  10. ncbi Phototransduction by retinal ganglion cells that set the circadian clock
    David M Berson
    Department of Neuroscience, Brown University, Providence, RI, 02912 USA
    Science 295:1070-3. 2002

Detail Information

Publications279 found, 100 shown here

  1. ncbi Imaging intracellular fluorescent proteins at nanometer resolution
    Eric Betzig
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA
    Science 313:1642-5. 2006
    ....
  2. ncbi The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism
    E Virginia Armbrust
    School of Oceanography, University of Washington, Seattle, WA 98195, USA
    Science 306:79-86. 2004
    ....
  3. pmc Ultra-high resolution imaging by fluorescence photoactivation localization microscopy
    Samuel T Hess
    Department of Physics and Astronomy, University of Maine, Orono, ME 04469, USA
    Biophys J 91:4258-72. 2006
    Biological structures span many orders of magnitude in size, but far-field visible light microscopy suffers from limited resolution...
  4. pmc Channelrhodopsin-2, a directly light-gated cation-selective membrane channel
    Georg Nagel
    Max Planck Institut fur Biophysik, Marie Curie Strasse 15, 60439 Frankfurt, Germany
    Proc Natl Acad Sci U S A 100:13940-5. 2003
    ..Some of them represent membrane ion transport proteins such as bacteriorhodopsin, a light-driven proton pump, or channelrhodopsin-1 (ChR1), a recently identified light-gated proton channel from the green ..
  5. pmc Evidence for a SAL1-PAP chloroplast retrograde pathway that functions in drought and high light signaling in Arabidopsis
    Gonzalo M Estavillo
    Australian Research Council Centre of Excellence in Plant Energy Biology, Research School of Biology, Australian National University Canberra, Acton, Australian Capital Territory 0200, Australia
    Plant Cell 23:3992-4012. 2011
    ..5'-phosphate [PAP]), which accumulates in Arabidopsis thaliana in response to drought and high light (HL) stress and that the enzyme SAL1 regulates its levels by dephosphorylating PAP to AMP...
  6. ncbi Far-field optical nanoscopy
    Stefan W Hell
    Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, 37070 Gottingen, and German Cancer Research Center DKFZ, High Resolution Optical Microscopy Division, 69120 Heidelberg, Germany
    Science 316:1153-8. 2007
    ..of a lens-based optical microscope to discern details that are closer together than half of the wavelength of light. However, for its most popular imaging mode, fluorescence microscopy, the diffraction barrier is crumbling...
  7. ncbi Multimodal fast optical interrogation of neural circuitry
    Feng Zhang
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 446:633-9. 2007
    ..Here we identify and develop an archaeal light-driven chloride pump (NpHR) from Natronomonas pharaonis for temporally precise optical inhibition of neural ..
  8. pmc Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity
    S Hattar
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Science 295:1065-70. 2002
    The primary circadian pacemaker, in the suprachiasmatic nucleus (SCN) of the mammalian brain, is photoentrained by light signals from the eyes through the retinohypothalamic tract...
  9. ncbi VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism
    Özgür Bayram
    Institute of Microbiology and Genetics, Georg August University, D 37077 Gottingen, Germany
    Science 320:1504-6. 2008
    Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In Aspergillus nidulans, light inhibits sexual reproduction as well as secondary metabolism...
  10. ncbi Phototransduction by retinal ganglion cells that set the circadian clock
    David M Berson
    Department of Neuroscience, Brown University, Providence, RI, 02912 USA
    Science 295:1070-3. 2002
    b>Light synchronizes mammalian circadian rhythms with environmental time by modulating retinal input to the circadian pacemaker-the suprachiasmatic nucleus (SCN) of the hypothalamus...
  11. pmc F-box proteins in rice. Genome-wide analysis, classification, temporal and spatial gene expression during panicle and seed development, and regulation by light and abiotic stress
    Mukesh Jain
    Interdisciplinary Centre for Plant Genomics and Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110 021, India
    Plant Physiol 143:1467-83. 2007
    ..The expression of several F-box protein-encoding genes is also influenced by light. The structure and function of F-box proteins in plants is discussed in light of these results and the published ..
  12. ncbi Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses
    Georg Nagel
    Max Planck Institute for Biophysics, Max von Laue Str 3, D 60438 Frankfurt, Germany
    Curr Biol 15:2279-84. 2005
    ..Here, we employed channelrhodopsin-2 (ChR2), a directly light-gated cation channel from the green alga Chlamydomonas reinhardtii, in excitable cells of the nematode ..
  13. pmc Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins
    Joanna Mattis
    Department of Bioengineering, Stanford University, Stanford, California, USA
    Nat Methods 9:159-72. 2012
    ....
  14. ncbi Hd3a protein is a mobile flowering signal in rice
    Shojiro Tamaki
    Laboratory of Plant Molecular Genetics, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 0101, Japan
    Science 316:1033-6. 2007
    ..We show that the protein encoded by Hd3a, a rice ortholog of FT, moves from the leaf to the shoot apical meristem and induces flowering in rice. These results suggest that the Hd3a protein may be the rice florigen...
  15. ncbi Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage
    Antony N Dodd
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK
    Science 309:630-3. 2005
    ..photosynthetic advantage is conferred by correct matching of the circadian clock period with that of the external light-dark cycle...
  16. pmc A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
    Linda Madisen
    Allen Institute for Brain Science, Seattle, Washington, USA
    Nat Neurosci 15:793-802. 2012
    ..mediated Cre-dependent, robust activation or silencing of cortical pyramidal neurons in vitro and in vivo upon light stimulation, with ChR2-EYFP and Arch-ER2 demonstrating light sensitivity approaching that of in utero or virally ..
  17. pmc Improving the photostability of bright monomeric orange and red fluorescent proteins
    Nathan C Shaner
    Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Methods 5:545-51. 2008
    ..and TagRFP (a monomeric derivative of eqFP578 from Entacmaea quadricolor) that maintain most of the beneficial qualities of the original proteins and perform as reliably as Aequorea victoria GFP derivatives in fusion constructs...
  18. ncbi Coordination of circadian timing in mammals
    Steven M Reppert
    Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 418:935-41. 2002
    ..However, these independent rhythms are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.
  19. pmc The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth
    Dmitri A Nusinow
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego 9500 Gilman Drive, La Jolla, California 92093 0130, USA
    Nature 475:398-402. 2011
    The circadian clock is required for adaptive responses to daily and seasonal changes in environmental conditions. Light and the circadian clock interact to consolidate the phase of hypocotyl cell elongation to peak at dawn under diurnal ..
  20. ncbi A molecular framework for light and gibberellin control of cell elongation
    Miguel de Lucas
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia CSIC, Campus Univ Autónoma de Madrid, Cantoblanco c Darwin 3, 28049 Madrid, Spain
    Nature 451:480-4. 2008
    Cell elongation during seedling development is antagonistically regulated by light and gibberellins (GAs)...
  21. ncbi Shedding light onto live molecular targets
    Ralph Weissleder
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Nat Med 9:123-8. 2003
  22. ncbi Crystal structure of rhodopsin: A G protein-coupled receptor
    K Palczewski
    Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA
    Science 289:739-45. 2000
    ..Identification of a set of residues that mediate interactions between the transmembrane helices and the cytoplasmic surface, where G-protein activation occurs, also suggests a possible structural change upon photoactivation...
  23. ncbi Redox regulation in photosynthetic organisms: signaling, acclimation, and practical implications
    Christine H Foyer
    School of Agriculture, Food and Rural Development, Agriculture Building, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Antioxid Redox Signal 11:861-905. 2009
    ..involved in photosynthesis such as plastoquinone show rapid and often transient shifts in response to changes in light and other environmental signals...
  24. ncbi Ultrafast optogenetic control
    Lisa A Gunaydin
    Department of Bioengineering, Stanford University, Stanford, California, USA
    Nat Neurosci 13:387-92. 2010
    ..when ChR2 is expressed at high levels, extra spikes (for example, doublets) can occur in response to a single light pulse, with potential implications as doublets may be important for neural coding...
  25. pmc Macroscopic invisibility cloaking of visible light
    Xianzhong Chen
    School of Physics and Astronomy, University of Birmingham, Birmingham B15 2TT, UK
    Nat Commun 2:176. 2011
    ..The cloak operates at visible frequencies and is capable of hiding, for a specific light polarization, three-dimensional objects of the scale of centimetres and millimetres...
  26. pmc Coordinated regulation of Arabidopsis thaliana development by light and gibberellins
    Suhua Feng
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520 8104, USA
    Nature 451:475-9. 2008
    b>Light and gibberellins (GAs) mediate many essential and partially overlapping plant developmental processes. DELLA proteins are GA-signalling repressors that block GA-induced development...
  27. pmc Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision
    Jennifer L Ecker
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuron 67:49-60. 2010
    Using the photopigment melanopsin, intrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light to drive circadian clock resetting and pupillary constriction...
  28. ncbi Optical sectioning deep inside live embryos by selective plane illumination microscopy
    Jan Huisken
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Science 305:1007-9. 2004
    ..We also demonstrate that SPIM can be applied to visualize the embryogenesis of the relatively opaque Drosophila melanogaster in vivo...
  29. ncbi Physiology of circadian entrainment
    Diego A Golombek
    Laboratory of Chronobiology, Department of Science and Technology, University of Quilmes Consejo Nacional de Investigaciones Científicas y Tecnológicas CONICET, Quilmes, Argentina
    Physiol Rev 90:1063-102. 2010
    ..circadian rhythms need to be entrained daily by means of Zeitgeber ("time giver") signals, such as the light-dark cycle...
  30. pmc Blue light is essential for high light acclimation and photoprotection in the diatom Phaeodactylum tricornutum
    Benjamin Schellenberger Costa
    Institute of Biology, University of Leipzig, Johannisallee 21 23, D 04103 Leipzig, Germany
    J Exp Bot 64:483-93. 2013
    The objective of the present study was to test the hypothesis that the acclimation to different light intensities in the diatom Phaeodactylum tricornutum is controlled by light quality perception mechanisms...
  31. ncbi Mapping the core of the Arabidopsis circadian clock defines the network structure of the oscillator
    W Huang
    Center for Research in Agricultural Genomics, Barcelona 08193, Spain
    Science 336:75-9. 2012
    ..Our study overturns the prevailing model of the Arabidopsis circadian clock, showing that the morning and evening oscillator loops are connected through the repressing activity of TOC1...
  32. pmc Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors
    Lauren R Polstein
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    J Am Chem Soc 134:16480-3. 2012
    ..To meet these criteria, a gene regulation system was engineered that combines light-sensitive proteins and programmable zinc finger transcription factors...
  33. pmc Dynamic plastid redox signals integrate gene expression and metabolism to induce distinct metabolic states in photosynthetic acclimation in Arabidopsis
    Katharina Bräutigam
    Lehrstuhl fur Pflanzenphysiologie, Institut für Allgemeine Botanik und Pflanzenphysiologie, Friedrich Schiller Universitat Jena, Jena, Germany
    Plant Cell 21:2715-32. 2009
    ....
  34. pmc Suprachiasmatic nucleus: cell autonomy and network properties
    David K Welsh
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Annu Rev Physiol 72:551-77. 2010
    ..The SCN network synchronizes its component cellular oscillators, reinforces their oscillations, responds to light input by altering their phase distribution, increases their robustness to genetic perturbations, and enhances ..
  35. ncbi Flavonoid biosynthesis-related genes in grape skin are differentially regulated by temperature and light conditions
    Akifumi Azuma
    Grape and Persimmon Research Station, National Institute of Fruit Tree Science, National Agriculture and Food Research Organization, NARO, Akitsu 301 2, Higashi Hiroshima, Hiroshima 739 2494, Japan
    Planta 236:1067-80. 2012
    Temperature and light are important environmental factors that affect flavonoid biosynthesis in grape berry skin...
  36. ncbi Exploring the molecular basis of responses to light in marine diatoms
    Frauke Angelique Depauw
    Universite Pierre et Marie Curie, Paris 06, Centre National de la Recherche Scientifique, UMR7238, Laboratoire de Génomique des Microorganismes, 75006 Paris, France
    J Exp Bot 63:1575-91. 2012
    b>Light is an essential source of energy for life on Earth and is one of the most important signals that organisms use to obtain information from the surrounding environment, on land and in the oceans...
  37. pmc Molecular and cellular approaches for diversifying and extending optogenetics
    Viviana Gradinaru
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Cell 141:154-65. 2010
    Optogenetic technologies employ light to control biological processes within targeted cells in vivo with high temporal precision...
  38. ncbi Broadband polarization-independent resonant light absorption using ultrathin plasmonic super absorbers
    Koray Aydin
    Thomas J Watson Laboratories of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA
    Nat Commun 2:517. 2011
    ..Our super absorber yields broadband and polarization-independent resonant light absorption over the entire visible spectrum (400-700 nm) with an average measured absorption of 0...
  39. pmc Rapid blue-light-mediated induction of protein interactions in living cells
    Matthew J Kennedy
    Department of Neurobiology, Duke University Medical Center, Durham North Carolina, USA
    Nat Methods 7:973-5. 2010
    ..Here we describe genetically encoded light-inducible protein-interaction modules based on Arabidopsis thaliana cryptochrome 2 and CIB1 that require no ..
  40. ncbi A pigment-binding protein essential for regulation of photosynthetic light harvesting
    X P Li
    Department of Plant and Microbial Biology, University of California, Berkeley 94720 3102, USA
    Nature 403:391-5. 2000
    Photosynthetic light harvesting in plants is regulated in response to changes in incident light intensity...
  41. pmc High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels
    Andre Berndt
    Experimental Biophysics, Humboldt Universitat zu Berlin, D 10115 Berlin, Germany
    Proc Natl Acad Sci U S A 108:7595-600. 2011
    ..has become an indispensable tool in neuroscience, allowing precise induction of action potentials with short light pulses...
  42. ncbi Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
    R J Lucas
    Department of Integrative and Molecular Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Campus, St Dunstans Road, London W6 8RF, UK
    Science 299:245-7. 2003
    ..protein melanopsin, and project to brain nuclei involved in non-image-forming visual functions such as pupillary light reflex and circadian photoentrainment...
  43. ncbi Rhythmic growth explained by coincidence between internal and external cues
    Kazunari Nozue
    Section of Plant Biology, College of Biological Sciences, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Nature 448:358-61. 2007
    ..Indeed, two important factors controlling stem growth are the internal circadian oscillator and external light levels...
  44. pmc In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2
    Benjamin R Arenkiel
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 54:205-18. 2007
    Channelrhodopsin-2 (ChR2) is a light-gated, cation-selective ion channel isolated from the green algae Chlamydomonas reinhardtii...
  45. ncbi Photoreceptor regulation of CONSTANS protein in photoperiodic flowering
    Federico Valverde
    Max Planck Institute for Plant Breeding, Carl von Linne Weg 10, D 50829 Cologne, Germany
    Science 303:1003-6. 2004
    ..Flowering is induced when CO messenger RNA expression coincides with the exposure of plants to light. However, how this promotes CO activity is unknown...
  46. pmc The zinc-finger protein Zat12 plays a central role in reactive oxygen and abiotic stress signaling in Arabidopsis
    Sholpan Davletova
    Department of Biochemistry and Molecular Biology, University of Nevada, Reno, 89557, USA
    Plant Physiol 139:847-56. 2005
    ..Zat12 gain- and loss-of-function lines, we assign a function for Zat12 during oxidative, osmotic, salinity, high light, and heat stresses...
  47. pmc Integration of low temperature and light signaling during cold acclimation response in Arabidopsis
    Rafael Catala
    Departamento de Biología Medioambiental, Centro de Investigaciones Biologicas Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, 28040 Madrid, Spain
    Proc Natl Acad Sci U S A 108:16475-80. 2011
    ..b>Light has been shown to be required for full cold acclimation, although how light and cold signals integrate and cross-..
  48. ncbi Reference gene selection for quantitative real-time PCR normalization in tomato subjected to nitrogen, cold, and light stress
    Trond Løvdal
    Faculty of Science and Technology, Centre for Organelle Research, University of Stavanger, N 4036 Stavanger, Norway
    Anal Biochem 387:238-42. 2009
    ..reference genes was tested during growth conditions of nitrogen (N) starvation, low temperature, and suboptimal light. The geNorm algorithm, using reciprocal cross-validation among a larger group of candidate references, was applied ..
  49. ncbi The role of the xanthophyll cycle and of lutein in photoprotection of photosystem II
    Peter Jahns
    Plant Biochemistry, Heinrich Heine University Dusseldorf, Universitatsstr 1, D 40225 Dusseldorf, Germany
    Biochim Biophys Acta 1817:182-93. 2012
    Photoprotection of photosystem II (PSII) is essential to avoid the light-induced damage of the photosynthetic apparatus due to the formation of reactive oxygen species (=photo-oxidative stress) under excess light...
  50. pmc TULIPs: tunable, light-controlled interacting protein tags for cell biology
    Devin Strickland
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois, USA
    Nat Methods 9:379-84. 2012
    ..We developed tunable light-inducible dimerization tags (TULIPs) based on a synthetic interaction between the LOV2 domain of Avena sativa ..
  51. ncbi Phytochrome interacting factors 4 and 5 control seedling growth in changing light conditions by directly controlling auxin signaling
    Patricia Hornitschek
    Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH 1015 Lausanne, Switzerland
    Plant J 71:699-711. 2012
    Plant growth is strongly influenced by the presence of neighbors that compete for light resources...
  52. pmc Transcriptome response of high- and low-light-adapted Prochlorococcus strains to changing iron availability
    Anne W Thompson
    MIT Department of Civil and Environmental Engineering, Cambridge, MA02139, USA
    ISME J 5:1580-94. 2011
    ..These genes are interesting targets for studying the adaptation of natural Prochlorococcus assemblages to local iron conditions as they show more diversity than other genomic regions in environmental metagenomic databases...
  53. ncbi Macroscopic invisibility cloak for visible light
    Baile Zhang
    Singapore MIT Alliance for Research and Technology Centre, Singapore 117543, Singapore
    Phys Rev Lett 106:033901. 2011
    ..Its working bandwidth encompassing red, green, and blue light is also demonstrated.
  54. ncbi A thermosensory pathway controlling flowering time in Arabidopsis thaliana
    Miguel A Blázquez
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Genet 33:168-71. 2003
    Onset of flowering is controlled by environmental signals such as light and temperature...
  55. ncbi Modulation of locomotor activity in larval zebrafish during light adaptation
    Harold A Burgess
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    J Exp Biol 210:2526-39. 2007
    ..illumination elicit large angle turns, distinct from startle responses, which orient larvae toward the source of light. In continuing darkness, larvae are transiently hyperactive before adopting a quiescent state...
  56. ncbi Retinal repair by transplantation of photoreceptor precursors
    R E MacLaren
    Division of Molecular Therapy, University College London Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Nature 444:203-7. 2006
    ..These findings define the ontogenetic stage of donor cells for successful rod photoreceptor transplantation...
  57. ncbi Sensing and responding to excess light
    Zhirong Li
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Plant Biol 60:239-60. 2009
    Plants and algae often absorb too much light-more than they can actually use in photosynthesis...
  58. pmc Membrane lipids of symbiotic algae are diagnostic of sensitivity to thermal bleaching in corals
    Dan Tchernov
    Environmental Biophysics and Molecular Ecology Program, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, 71 Dudley Road, New Brunswick, NJ 08901, USA
    Proc Natl Acad Sci U S A 101:13531-5. 2004
    ..Although the phenomenon is correlated with relatively small increases in sea-surface temperature and enhanced light intensity, the underlying physiological mechanism remains unknown...
  59. pmc Analysis of transcription factor HY5 genomic binding sites revealed its hierarchical role in light regulation of development
    Jungeun Lee
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Conecticut 06520 8104, USA
    Plant Cell 19:731-49. 2007
    ..We demonstrated that in vivo association of HY5 with promoter targets is not altered under distinct light qualities or during light-to-dark transition...
  60. pmc Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision
    Ali D Guler
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Nature 453:102-5. 2008
    Rod and cone photoreceptors detect light and relay this information through a multisynaptic pathway to the brain by means of retinal ganglion cells (RGCs)...
  61. pmc Non-redundant odor coding by sister mitral cells revealed by light addressable glomeruli in the mouse
    Ashesh K Dhawale
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Nat Neurosci 13:1404-12. 2010
    ..By selectively stimulating individual glomeruli with light, we identified mitral/tufted cells that receive common input (sister cells)...
  62. pmc PAS domains: internal sensors of oxygen, redox potential, and light
    B L Taylor
    Department of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Microbiol Mol Biol Rev 63:479-506. 1999
    ..They function as input modules in proteins that sense oxygen, redox potential, light, and some other stimuli...
  63. pmc Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice
    S Hattar
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 424:76-81. 2003
    ..photoreceptive system exists that conveys photic information for accessory visual functions such as pupillary light reflex and circadian photo-entrainment...
  64. pmc Recognizing biological motion and emotions from point-light displays in autism spectrum disorders
    Evelien Nackaerts
    Department of Biomedical Kinesiology, Group Biomedical Sciences, Research Center for Movement Control and Neuroplasticity, KU Leuven, Heverlee, Belgium
    PLoS ONE 7:e44473. 2012
    ..assessed from two observational tasks involving the recognition of 'biological motion' and 'emotions' from point-light displays (PLDs). Eye movements were recorded during the completion of the tests...
  65. ncbi Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds
    Takashi Yoshimura
    Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya, 464 8601, Japan
    Nature 426:178-81. 2003
    ..intracellular deiodination of thyroxine (T4) prohormone to the active 3,5,3'-triiodothyronine (T3), is induced by light in Japanese quail...
  66. ncbi Molecular dynamics of the diatom thylakoid membrane under different light conditions
    Bernard Lepetit
    CNRS UMR6250 LIENSs, Institute for Coastal and Environmental Research ILE, University of La Rochelle, 2 rue Olympe de Gouges, 17042, La Rochelle cedex, France
    Photosynth Res 111:245-57. 2012
    ..about the structural and functional changes within the thylakoid membrane of diatoms acclimated to different light conditions...
  67. ncbi Identification of alternative splicing events regulated by an Arabidopsis serine/arginine-like protein, atSR45a, in response to high-light stress using a tiling array
    Kazuya Yoshimura
    Department of Food and Nutritional Science, College of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto cho, Kasugai, Aichi 487 8501, Japan
    Plant Cell Physiol 52:1786-805. 2011
    ..rich-like protein, atSR45a, interacts with other splicing factors and its expression is markedly induced by high-light stress, suggesting the involvement of atSR45a in the regulation of stress-responsive alternative splicing...
  68. ncbi Targeted destabilization of HY5 during light-regulated development of Arabidopsis
    M T Osterlund
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520 8104, USA
    Nature 405:462-6. 2000
    Arabidopsis seedlings display contrasting developmental patterns depending on the ambient light. Seedlings grown in the light develop photomorphogenically, characterized by short hypocotyls and expanded green cotyledons...
  69. ncbi Ultra light-sensitive and fast neuronal activation with the Ca²+-permeable channelrhodopsin CatCh
    Sonja Kleinlogel
    Max Planck Institute of Biophysics, Department of Biophysical Chemistry, Frankfurt am Main, Germany
    Nat Neurosci 14:513-8. 2011
    The light-gated cation channel channelrhodopsin-2 (ChR2) has rapidly become an important tool in neuroscience, and its use is being considered in therapeutic interventions...
  70. ncbi Spatiotemporal control of gene expression by a light-switchable transgene system
    Xue Wang
    Synthetic Biology and Biotechnology Laboratory, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, China
    Nat Methods 9:266-9. 2012
    We developed a light-switchable transgene system based on a synthetic, genetically encoded light-switchable transactivator...
  71. ncbi Melanopsin is required for non-image-forming photic responses in blind mice
    Satchidananda Panda
    Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
    Science 301:525-7. 2003
    Although mice lacking rod and cone photoreceptors are blind, they retain many eye-mediated responses to light, possibly through photosensitive retinal ganglion cells...
  72. ncbi Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment
    Zhenjiang Zhang
    CAS Key Laboratory for Biomedical, Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Adv Mater 24:1418-23. 2012
    ..With doxorubicin hydrochloride loaded, Au@SiO(2)-DOX show two light-mediated therapeutic modes: low power density laser-triggered drug release for chemotherapy, and high power ..
  73. ncbi Role of the Arabidopsis glucose sensor HXK1 in nutrient, light, and hormonal signaling
    Brandon Moore
    Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 300:332-6. 2003
    ..HXK1 coordinates intrinsic signals with extrinsic light intensity...
  74. pmc Optical control of zebrafish behavior with halorhodopsin
    Aristides B Arrenberg
    Department of Physiology, Program in Neuroscience, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158 2324, USA
    Proc Natl Acad Sci U S A 106:17968-73. 2009
    Expression of halorhodopsin (NpHR), a light-driven microbial chloride pump, enables optical control of membrane potential and reversible silencing of targeted neurons...
  75. pmc Phytochrome signaling mechanisms and the control of plant development
    Meng Chen
    Department of Biology, Duke University, Durham, NC 27708, USA
    Trends Cell Biol 21:664-71. 2011
    ..by dramatic changes in morphology and global alterations in gene expression that optimizes the plant body plan for light capture...
  76. ncbi Shedding light on the mitochondrial permeability transition
    Fernanda Ricchelli
    Department of Biology, University of Padova, Padova, Italy
    Biochim Biophys Acta 1807:482-90. 2011
    ....
  77. pmc Energy starved Candidatus Pelagibacter ubique substitutes light-mediated ATP production for endogenous carbon respiration
    Laura Steindler
    Department of Microbiology, Oregon State University, Corvallis, Oregon, United States of America
    PLoS ONE 6:e19725. 2011
    ..ubique, a member of the SAR11 clade, constitutively expresses proteorhodopsin (PR) proteins that can function as light-dependent proton pumps...
  78. ncbi Light-regulated plant growth and development
    Chitose Kami
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    Curr Top Dev Biol 91:29-66. 2010
    Plants are sessile and photo-autotrophic; their entire life cycle is thus strongly influenced by the ever-changing light environment...
  79. ncbi How do environmental stresses accelerate photoinhibition?
    Shunichi Takahashi
    Molecular Plant Physiology Group and Australian Research Council Centre of Excellence in Plant Energy Biology, Research School of Biological Sciences, Australian National University, PO Box 475, Canberra, ACT 0200, Australia
    Trends Plant Sci 13:178-82. 2008
    ..The latter results in the creation of reactive oxygen species (ROS), which in turn block the synthesis of PSII proteins in chloroplasts...
  80. pmc An optical marker based on the UV-induced green-to-red photoconversion of a fluorescent protein
    Ryoko Ando
    Laboratory for Cell Function and Dynamics, Advanced Technology Development Center, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 99:12651-6. 2002
    ..encoding a fluorescent protein from a stony coral, Trachyphyllia geoffroyi, which emits green, yellow, and red light. The protein, named Kaede, includes a tripeptide, His-Tyr-Gly, that acts as a green chromophore that can be ..
  81. pmc Rapid induction of distinct stress responses after the release of singlet oxygen in Arabidopsis
    Roel G L op den Camp
    Institute of Plant Sciences, Plant Genetics, Swiss Federal Institute of Technology, CH 8092 Zurich, Switzerland
    Plant Cell 15:2320-32. 2003
    ..After a dark-to-light shift, the generation of singlet oxygen, a nonradical reactive oxygen species, starts within the first minute of ..
  82. ncbi Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration
    Andreas Wenzel
    Laboratory for Retinal Cell Biology, Department Ophthalmology, University Eye Clinic, University of Zurich, Frauenklinkstrasse 24, CH 8091 Zurich, Switzerland
    Prog Retin Eye Res 24:275-306. 2005
    Human retinal dystrophies and degenerations and light-induced retinal degenerations in animal models are sharing an important feature: visual cell death by apoptosis...
  83. ncbi Electrophysiology in the age of light
    Massimo Scanziani
    Howard Hughes Medical Institute and Department of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nature 461:930-9. 2009
    ..Although electrophysiological characterization of channels, cells and neural circuits will remain necessary, new combinations of electrophysiology and imaging should lead to transformational discoveries in neuroscience...
  84. ncbi Unexpected features of Drosophila circadian behavioural rhythms under natural conditions
    Stefano Vanin
    Department of Biology, University of Padova, Padova 35131, Italy
    Nature 484:371-5. 2012
    ..Under laboratory light-dark cycles, flies show enhanced activity before lights on and off signals, and these anticipatory responses have ..
  85. ncbi Cytokinin action in plant development
    Tomáš Werner
    Institute of Biology Applied Genetics, Dahlem Centre of Plant Sciences DCPS, Freie Universitat Berlin, Albrecht Thaer Weg 6, D 14195 Berlin, Germany
    Curr Opin Plant Biol 12:527-38. 2009
    ..Cytokinin also mediates the responses to variable extrinsic factors, such as light conditions in the shoot and availability of nutrients and water in the root, and has a role in the response to ..
  86. pmc Proteorhodopsin phototrophy promotes survival of marine bacteria during starvation
    Laura Gomez-Consarnau
    Marine Microbiology, School of Natural Sciences, Linnaeus University, Kalmar, Sweden
    PLoS Biol 8:e1000358. 2010
    ..We demonstrate an increased long-term survival of AND4 when starved in seawater exposed to light rather than held in darkness...
  87. ncbi Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique
    Richard C Murdock
    Applied Biotechnology Branch, Human Effectiveness Directorate Air Force Research Laboratory HEPB, Wright Patterson Air Force Board, Ohio 45433, USA
    Toxicol Sci 101:239-53. 2008
    ..techniques in aqueous or biological solutions have consisted of the use of ultra-high illumination light microscopy and disc centrifuge sedimentation; however, these techniques are limited by the measurement size range...
  88. pmc Photoreceptor signaling: supporting vision across a wide range of light intensities
    Vadim Y Arshavsky
    Departments of Ophthalmology and Pharmacology, Duke University, Durham, North Carolina 27710, USA
    J Biol Chem 287:1620-6. 2012
    ..kinetics of signaling and the large-scale movements of proteins underlying signaling has led to a deeper appreciation of the photoreceptor's unique challenge in mediating the first steps in vision over a wide range of light intensities.
  89. ncbi Emergent biogeography of microbial communities in a model ocean
    Michael J Follows
    Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, 54 1514 MIT, Cambridge, MA 02139, USA
    Science 315:1843-6. 2007
    ..This flexible representation of community structure can be used to explore relations between ecosystems, biogeochemical cycles, and climate change...
  90. pmc Photoisomerization of a rotaxane hydrogen bonding template: light-induced acceleration of a large amplitude rotational motion
    Francesco G Gatti
    School of Chemistry, University of Edinburgh, The King s Buildings, West Mains Road, United Kingdom
    Proc Natl Acad Sci U S A 100:10-4. 2003
    ..Here we demonstrate that the rate of rotation of the interlocked components of fumaramide-derived [2]rotaxanes can be accelerated, by >6 orders of magnitude, by isomerizing them to the corresponding maleamide [2]rotaxanes by using light.
  91. pmc RpoH(II) activates oxidative-stress defense systems and is controlled by RpoE in the singlet oxygen-dependent response in Rhodobacter sphaeroides
    Aaron M Nuss
    Institut fur Mikrobiologie und Molekularbiologie, Heinrich Buff Ring 26, 35392 Giessen, Germany
    J Bacteriol 191:220-30. 2009
    ..Therefore, we conclude that systems pivotal for the organism's defense against photooxidative stress are strongly dependent on GSH and are specifically recognized by RpoH(II) in R. sphaeroides...
  92. pmc LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity
    Ozlem Sarikaya Bayram
    Institute of Microbiology and Genetics, Department of Molecular Microbiology and Genetics, Georg August University, Gottingen, Germany
    PLoS Genet 6:e1001226. 2010
    VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual reproduction and secondary metabolism in Aspergillus nidulans...
  93. pmc The phosducin-like protein PhLP1 impacts regulation of glycoside hydrolases and light response in Trichoderma reesei
    Doris Tisch
    Research Area of Gene Technology and Applied Biochemistry, Institute for Chemical Engineering, Vienna University of Technology, Gumpendorferstrasse 1a, A 1060 Wien, Austria
    BMC Genomics 12:613. 2011
    ..transcription of cellulase genes as well as efficiency of the secreted cellulase mixture are modulated by light. Components of the heterotrimeric G-protein pathway interact with light-dependent signals, rendering this pathway ..
  94. pmc Crystal structure of the channelrhodopsin light-gated cation channel
    Hideaki E Kato
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 2 11 16 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nature 482:369-74. 2012
    Channelrhodopsins (ChRs) are light-gated cation channels derived from algae that have shown experimental utility in optogenetics; for example, neurons expressing ChRs can be optically controlled with high temporal precision within ..
  95. ncbi Adaptation of photoperiodic control pathways produces short-day flowering in rice
    Ryosuke Hayama
    Laboratory of Plant Molecular Genetics, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 0101, Japan
    Nature 422:719-22. 2003
    ....
  96. pmc Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography
    M Dominik Fischer
    Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
    PLoS ONE 4:e7507. 2009
    ..Optical coherence tomography (OCT) is a novel method of retinal in vivo imaging. In this study, we assessed the potential of OCT to yield histology-analogue sections in mouse models of retinal degeneration...
  97. pmc Bacterial responses to photo-oxidative stress
    EVA C ZIEGELHOFFER
    Department of Bacteriology, University of Wisconsin Madison, 1550 Linden Drive, Madison, Wisconsin 53706, USA
    Nat Rev Microbiol 7:856-63. 2009
    ..Traditionally, the response to singlet oxygen has been termed photo-oxidative stress, as light-dependent processes in photosynthetic cells are major biological sources of singlet oxygen...
  98. ncbi Coherently wired light-harvesting in photosynthetic marine algae at ambient temperature
    Elisabetta Collini
    Department of Chemistry, Institute for Optical Sciences and Centre for Quantum Information and Quantum Control, University of Toronto, 80 St George Street, Toronto, Ontario, M5S 3H6 Canada
    Nature 463:644-7. 2010
    ..Crucial components for the photosynthetic process are antenna proteins, which absorb light and transmit the resultant excitation energy between molecules to a reaction centre...
  99. ncbi Segregation of nitrogen fixation and oxygenic photosynthesis in the marine cyanobacterium Trichodesmium
    I Berman-Frank
    Environmental Biophysics and Molecular Ecology Program, Institute of Marine and Coastal Sciences, Rutgers University, 71 Dudley Road, New Brunswick, NJ 08901, USA
    Science 294:1534-7. 2001
    ....
  100. ncbi MYBL2 is a new regulator of flavonoid biosynthesis in Arabidopsis thaliana
    Christian Dubos
    INRA and AgroParisTech, UMR204, Seed Biology Laboratory, IJPB, Route de Saint Cyr 78026 Versailles, France
    Plant J 55:940-53. 2008
    ..Finally, MYBL2 expression studies, including its inhibition by light-induced stress, allowed us to hypothesise a physiological role for MYBL2...
  101. ncbi Light trapping in silicon nanowire solar cells
    Erik Garnett
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nano Lett 10:1082-7. 2010
    ..path length and minority carrier diffusion length necessitates either a high absorption coefficient or excellent light trapping...

Research Grants55

  1. "3D ULTRASONIC HOLOGRAPHY FOR CARDIAC AND TUMOR IMAGING"
    JAMES LONGWORTH; Fiscal Year: 1991
    ....
  2. Manganese-enhanced MRI Studies of Retinal Neovascularization
    BRUCE BERKOWITZ; Fiscal Year: 2008
    ..We have validated that known retinal layer-specific changes in neuronal function / ion demand during light and dark adaptation can be robustly measured by high resolution MEMRI following systemic administration of a non-..
  3. MR STUDIES OF EXPERIMENTAL RETINOPATHY OF PREMATURITY
    BRUCE BERKOWITZ; Fiscal Year: 2001
    ..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
  4. Retinal Oxygenation in Diabetic Retinopathy
    BRUCE BERKOWITZ; Fiscal Year: 2004
    ..The results of these studies could lead to the development of a non-invasive real time method for the early evaluation of diabetic retinopathy and its treatment. ..
  5. Using light to increase visual and perceptual cues and decrease falls risk
    MARIANA FIGUEIRO; Fiscal Year: 2010
    ..1990). Under low light levels even high contrast objects, such as door frames and objects on the floor, can drop below threshold, leading ..
  6. Probing Premenstrual Dysphoric Disorder with Light
    Barbara Parry; Fiscal Year: 2007
    ..direction and a decreased magnitude of phase-shift responses in melatonin offset time alter a morning bright light pulse...
  7. Biological Rhythms in Postpartum Depression
    Barbara Parry; Fiscal Year: 2009
    ..This study would serve as the basis of future studies in which treatments designed to correct these underlying abnormalities in circadian rhythms, and restore them to those of NC women, thereby would improve mood in DP. ..
  8. Light-regulated genes affecting the pathogen potential of Cryptococcus neoformans
    Alexander Idnurm; Fiscal Year: 2008
    ..unreadable] [unreadable] Light influences many properties in species of fungi, such as regulating sexual or asexual sporulation, pigment ..
  9. Retinal Neurons Afferent to the Circadian System
    GARY PICKARD; Fiscal Year: 2005
    ..To understand completely how light regulates our biological clock, we must understand which neurons convert light into an electrical signal and how ..
  10. Retinal Neurons Afferent to the Circadian System
    GARY EDWARD PICKARD; Fiscal Year: 2010
    b>Light entrains the suprachiasmatic nucleus (SCN), a circadian oscillator and a primary component of the mammalian circadian system...
  11. Neuromodulators and Signaling Cascades in Retina
    P Iuvone; Fiscal Year: 2007
    ..In addition to being regulated by light, aspects of photoreceptor physiology are subject to control by neuromodulators, such as dopamine, adenosine, ..
  12. Eukaryotic Membrane Protein Folding in E. coli
    John Spudich; Fiscal Year: 2006
    ..Submitted in response to PA-03-100 High Impact/High Risk Research and PA-02-060 Structural Biology of Membrane Proteins. ..
  13. Nanobiophotonics Enabled Tumor Surgery and Intraoperative PDT
    Raoul Kopelman; Fiscal Year: 2007
    ..The surgical exposure, created during resection, will provide a corridor for the efficient delivery of visible light necessary for photodynamic therapy...
  14. Brain, Behavior and Biological Rhythms
    LAWRENCE MORIN; Fiscal Year: 2006
    ..evaluate the role played by various parts in the visual pathway in assessing circadian rhythm system response to light. Drug and lesion experiments will, in sequential fashion, determine whether the pupil, retina, SCN or IGL ..
  15. PRACTICAL CIRCADIAN INTERVENTIONS FOR NIGHT SHIFT WORK
    CHARMANE EASTMAN; Fiscal Year: 2007
    ..We have shown, in simulated night shift studies, that appropriately timed bright light during the night shift combined with specific dark periods for daytime sleep can produce complete re-alignment of ..
  16. Nanoarray-Type Detection of Oct3/4 and Cdx2 using AuNPs and E-beam Patterns
    Jeong Yeol Yoon; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. Molecular Mechanisms of Natural Variation in Arabidopsis
    Joanne Chory; Fiscal Year: 2008
    ..to the environment? Among the best-studied plant signaling pathways are those that mediate the effects of ambient light, along with those that integrate light information with other variables to control flowering...
  18. Real-Time PDT Dosimetry with Feedback Light Delivery
    Timothy Zhu; Fiscal Year: 2008
    ..The explicit PDT dose is essentially the product of drug concentration and light fluence for a given photosensitizer and tissue oxygenation...
  19. Database of Functional SNPs in Cancer-Related Environmentally Responsive Genes
    Yong Zhu; Fiscal Year: 2009
    ..Findings from this study will enhance the use of SNPs in future phenotypic studies and molecular epidemiologic approaches to address questions related to gene-environment interaction in disease risk estimate. ..
  20. Mechanisms of Cone Pigment Deactivation
    Cheryl Craft; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Both rod and cone photoreceptors absorb light, triggering an amplification cascade, which produces membrane hyperpolarization through closure of selective ion channels...
  21. Phase response curves for home remedies to treat circadian misalignment
    Charmane I Eastman; Fiscal Year: 2010
    ..Both bright light and melatonin are able to reset or phase shift the circadian clock, and have been used to help people adapt to ..
  22. Nanoparticle Enabled Intraoperative Imaging and Therapy
    Raoul Kopelman; Fiscal Year: 2009
    ..surgical exposure, performed for resection, will provide a corridor for the efficient delivery of visible laser light to unresectable or occult tumor, for photodynamic therapy...
  23. Molecular Characterization of Chick Retina during Refractive Development
    RICHARD ALAN STONE; Fiscal Year: 2010
    ....
  24. Effects of Short and Long Nights on the Circadian Clock
    CHARMANE EASTMAN; Fiscal Year: 2006
    ..Humans are exposed to a light dark (LD) cycle created by natural and artificial light alternating with sleep...
  25. Becton Dickenson FACSAria Cell Sorter
    John Nolan; Fiscal Year: 2006
    ..The FACSAria plays a key role in the development of an advanced flow cytometry development and application capability at LJBI. [unreadable] [unreadable]..
  26. MOLECULAR ANGLE TRANSITIONS IN MUSCLE
    THOMAS BURGHARDT; Fiscal Year: 2001
    ....
  27. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  28. Support for 2002 GRC on Photosensory Receptors & Signal
    John Spudich; Fiscal Year: 2002
    ..We expect the conference will stimulate exciting discussion of emerging insights, general principles, and the most engaging mysteries on the cutting edge of photosensory signal transduction. ..
  29. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..If the results of preliminary studies are borne out by further investigation, UDCA could offer a safe and effective means for promoting clinical PDT efficacy. ..
  30. MYOPIA AND OCULAR GROWTH--NEURAL MECHANISMS
    Richard Stone; Fiscal Year: 2004
    ..aims: 1) define further the cholinergic mechanisms modulating eye growth and refraction; 2) understand the role of light and dark in influencing postnatal eye development; 3) further clarify retinal mechanisms modulating eye growth, ..
  31. CIRCADIAN RHYTHM ENTRAINMENT
    NORMAN RUBY; Fiscal Year: 2004
    A fundamental property of circadian rhythms is that they resynchronize (i.e., reentrain) to phase shifts of the light-dark cycle-a phenomenon which humans experience as "jet-lag"...
  32. Properties of AMPA and Kainate receptors
    P Iuvone; Fiscal Year: 2005
    ..Experiments will investigate if changes in the properties of the pore reflect the slowing of each gating mode of the AMPA receptor. ..
  33. Intrinsic Anatomy of the Circadian Rhythm System
    LAWRENCE MORIN; Fiscal Year: 2005
    ..of neuromodulator will be determined, and function will be assessed by evaluating co-localization of light-induced protein markers...
  34. Fluoride Agents: Pattern of their Effect on Early Caries
    Bennett Amaechi; Fiscal Year: 2005
    ..QLF data will be matched with their corresponding TMR data to determine the QLF parameters for lesions that were either completely remineralized or only arrested. ..
  35. Spatial & Temporal Interactions in Brightness Perception
    Barbara Blakeslee; Fiscal Year: 2006
    ..These two variables are confounded since their product determines the amount of light reaching the eye from a particular surface...
  36. mRNA expression by RPE cells in myopia
    Richard Stone; Fiscal Year: 2006
    ..We believe this program will lead to improved understanding of the etiology of refractive errors and ultimately to effective approaches to arrest myopia in children. ..
  37. 'Optical Nanosensors for Subcellular Chemical Imaging'
    Raoul Kopelman; Fiscal Year: 2001
    ..Such refined chemical imaging is expected to accelerate biomedical research in many areas. ..
  38. Proteomic Trajectory Mapping of Retinopathy of Prematurity
    Hiroyuki Matsumoto; Fiscal Year: 2008
    ..The results will contribute significantly to the development of drugs for the treatment of ROP and other related retinal diseases. [unreadable] [unreadable] [unreadable]..
  39. A Probabilistic Concept of Sensory Cortical Funcion
    Dale Purves; Fiscal Year: 2004
    ..abstract_text> ..
  40. Screening for Chronotherapeutics Applied to Hypersomnia and Other Sleep Disorders
    Carl Johnson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  41. Technology Development in Optical Coherence Tomography
    Emily McDowell; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  42. Clinical Validation of Combined ICDAS/QLF Exam for Early Caries Detection
    ANDREA GONCALVES FERREIRA ZANDONA; Fiscal Year: 2010
    ..Previous studies have indicated that Quantitative Light Induced Fluorescence (QLF), an imaging technique, has high sensitivity but low specificity for detection of the ..
  43. Genetic Analysis of Extreme Circadian/Sleep Phenotypes
    Anne Marie Chang; Fiscal Year: 2005
    ..abstract_text> ..
  44. Dendritic cell defects in cutaneous T-cell lymphoma
    Alain Rook; Fiscal Year: 2007
    ..abstract_text> ..
  45. The Role of Areas V1 and V2 in Target Selection
    Peter Schiller; Fiscal Year: 2008
    ..abstract_text> ..
  46. NEURAL CONTROL OF VISUALLY GUIDED EYE MOVEMENTS
    Peter Schiller; Fiscal Year: 2007
    ..abstract_text> ..
  47. ECM Regulation by Estrogen in ARMD
    Sharon Elliot; Fiscal Year: 2006
    ..Conversely, we expect that estrogen's antioxidant action on the cell membrane will diminish MPO-induced blebbing and that activation of estrogen receptors will modify matrix molecule dysregulation. ..
  48. ENVIRONMENTAL LIGHT AND RETINAL MEMBRANE DEVELOPMENT
    Daniel Organisciak; Fiscal Year: 2003
    DESCRIPTION (Adapted from applicant's abstract): This study seeks to determine the mechanisms of intense light-mediated photoreceptor cell degeneration...
  49. PECAM-1 AND REGULATION OF ANGIOGENESIS
    Nader Sheibani; Fiscal Year: 2003
    ..It is suggested that a therapeutic benefit can be derived by exploiting these signaling pathways to control the hypervascularization characteristic of arthritis. ..
  50. NEUROPEPTIDERGIC CONTROL OF MATERNAL BEHAVIOR
    BENJAMIN NEPHEW; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. BioMEMS Materials for Renal Tissue Engineering
    WILLIAM FISSELL; Fiscal Year: 2004
    ..Failure of RPTCs to grow on these substrates despite a variety of suface modifications would be extremely important, as it would indicate a need for new materials in bioengineering. ..
  52. Thrombospondin-1 and retininal vascular homeostasis
    Nader Sheibani; Fiscal Year: 2005
    ..This knowledge will provide the rationale for development of new therapeutic approaches for the prevention and/or treatment of ocular diseases with a neovascular component. ..
  53. BioMEMS Model of Glomerular Function
    WILLIAM FISSELL; Fiscal Year: 2008
    ..Third, HP and s will be measured for the NM-PBM membrane. Fourth, data from (1-3) will be compared with existing predictive models of glomerular function. ..